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Gilles Gosselin

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Bénédicte Dayde; Gilles Gosselin; Claire Pierra; Jean-Luc Pirat; Dominique Surleraux; Samira Benzaria; Jean-Noël Volle; David Virieux
Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states.
Jean-Francois Griffon; Audrey Dumas; Richard Storer; Jean-Pierre Sommadossi; Gilles Gosselin
Synthesis and antiviral evaluation of 4'-C-azidomethyl-beta-D-ribofuranosyl purine and pyrimidine nucleosides.
Marie Hamann; Claire Pierra; Jean-Pierre Sommadossi; Chiara Musiu; Luana Vargiu; Michel Liuzzi; Richard Storer; Gilles Gosselin
Synthesis and antiviral evaluation of thieno[3,4-d]pyrimidine C-nucleoside analogues of 2',3'-dideoxy- and 2',3'-dideoxy-2',3'-didehydro-adenosine and -inosine.

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All Publications

2012: Bénédicte Dayde; Gilles Gosselin; Claire Pierra; Jean-Luc Pirat; Dominique Surleraux; Samira Benzaria; Jean-Noël Volle; David Virieux
Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states.
Organic & biomolecular chemistry 2012;10(17):3448-54.
2009: Jean-Francois Griffon; Audrey Dumas; Richard Storer; Jean-Pierre Sommadossi; Gilles Gosselin
Synthesis and antiviral evaluation of 4'-C-azidomethyl-beta-D-ribofuranosyl purine and pyrimidine nucleosides.
Nucleosides, nucleotides & nucleic acids 2009;28(5):435-49.
2009: Marie Hamann; Claire Pierra; Jean-Pierre Sommadossi; Chiara Musiu; Luana Vargiu; Michel Liuzzi; Richard Storer; Gilles Gosselin
Synthesis and antiviral evaluation of thieno[3,4-d]pyrimidine C-nucleoside analogues of 2',3'-dideoxy- and 2',3'-dideoxy-2',3'-didehydro-adenosine and -inosine.
Bioorganic & medicinal chemistry 2009;17(6):2321-6.
2009: Gwenaëlle Sizun; David Dukhan; Jean-François Griffon; Ludovic Griffe; Jean-Christophe Meillon; Frédéric Leroy; Richard Storer; Jean-Pierre Sommadossi; Gilles Gosselin
Synthesis of the first example of a nucleoside analogue bearing a 5'-deoxy-beta-D-allo-septanose as a seven-membered ring sugar moiety.
Carbohydrate research 2009;344(4):448-53.
2008: Anne-Laure Villard; Gaëlle Coussot; Isabelle Lefebvre; Patrick Augustijns; Anne-Marie Aubertin; Gilles Gosselin; Suzanne Peyrottes; Christian Périgaud
Phenyl phosphotriester derivatives of AZT: variations upon the SATE moiety.
Bioorganic & medicinal chemistry 2008;16(15):7321-9.
2008: Frederic Leroy; Dominique Chaves; David Dukhan; Richard Storer; Jean-Pierre Sommadossi; Anna Giulia Loi; Alessandra Cadeddu; Maura Fanti; Nadia Boscu; Fabiola Bassetti; Michel Liuzzi; Gilles Gosselin
Synthesis and antiviral evaluation of 4-fluoropyrazole-3-carboxamide nucleoside derivatives.
Nucleic acids symposium series (2004) 2008;(52):617-8.
2008: Gwenaëlle Sizun; Jean-François Griffon; Ludovic Griffe; David Dukhan; Richard Storer; Jean-Pierre Sommadossi; Anna Giulia Loi; Chiara Musiu; Barbara Poddesu; Alessandra Cadeddu; Maura Fanti; Nadia Boscu; Fabiola Bassetti; Michel Liuzzi; Gilles Gosselin
Synthesis and antiviral evaluation of a seven-membered sugar ring nucleoside analog, 9-(5-deoxy-beta-D-allo-septanosyl)-adenine.
Nucleic acids symposium series (2004) 2008;(52):611-2.
2008: Marie Hamann; Claire Pierra; Richard Storer; Jean-Pierre Sommadossi; Anna Giulia Loi; Alessandra Cadeddu; Maura Fanti; Nadia Boscu; Fabiola Bassetti; Michel Liuzzi; Gilles Gosselin
Synthesis and study of 9-deazaguanosine derivatives as potential inhibitors of RNA virus replication.
Nucleic acids symposium series (2004) 2008;(52):603-4.
2008: Frederic Leroy; Dominique Chaves; David Dukhan; Richard Storer; Jean-Pierre Sommadossi; Anna Giulia Loi; Alessandra Cadeddu; Maura Fanti; Nadia Boscu; Fabiola Bassetti; Michel Liuzzi; Gilles Gosselin
Synthesis and antiviral evaluation of 7-fluoro-7-deaza-2-aminopurine nucleoside derivatives.
Nucleic acids symposium series (2004) 2008;(52):595-6.
2008: S Peyrottes; A-L Villard; G Coussot; P Augustijns; Isabelle Lefebvre; Anne-Marie Aubertin; Gilles Gosselin; Christian Périgaud
A step further in the SATE mononucleotide prodrug approach.
Nucleic acids symposium series (2004) 2008;(52):539-40.
2007: Annelaure Damont; David Dukhan; Gilles Gosselin; Jérôme Peyronnet; Richard Storer
Synthesis of 1'-C-fluoromethyladenosine.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1431-4.
2007: Mohamed Aljarah; Sarah Couturier; Gilles Gosselin; Christophe Mathé; Christian Périgaud
Revisited 3'-deoxy-3'-C-methyl-beta-D-ribonucleoside series.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):1125-8.
2007: Samira Benzaria; Dorothée Bardiot; Tony Bouisset; Clément Counor; Céline Rabeson; Claire Pierra; Richard Storer; Anna Giulia Loi; Alessandra Cadeddu; Massimo Mura; Chiara Musiu; Michel Liuzzi; Roberta Loddo; Svetlana Bergelson; Vadim Bichko; Edward Bridges; Erika Cretton-Scott; John Mao; Jean-Pierre Sommadossi; Maria Seifer; David Standring; Michele Tausek; Gilles Gosselin; Paolo La Colla
2'-C-Methyl branched pyrimidine ribonucleoside analogues: potent inhibitors of RNA virus replication.
Antiviral chemistry & chemotherapy 2007;18(4):225-42.
2006: Claire Pierra; Agnès Amador; Samira Benzaria; Erika Cretton-Scott; Marc D'Amours; John Mao; Sandrine Mathieu; Adel Moussa; Edward Bridges; David Standring; Jean-Pierre Sommadossi; Richard Storer; Gilles Gosselin
Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine.
Journal of medicinal chemistry 2006;49(22):6614-20.
2006: Pedro Besada; Dae Hong Shin; Stefano Costanzi; Hyojin Ko; Christophe Mathé; Julien Gagneron; Gilles Gosselin; Savitri Maddileti; T Kendall Harden; Kenneth Alan Jacobson
Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor.
Journal of medicinal chemistry 2006;49(18):5532-43.
2006: Christophe Mathé; Gilles Gosselin
L-nucleoside enantiomers as antivirals drugs: a mini-review.
Antiviral research 2006;71(2-3):276-81.
2006: Claire Pierra; David Dukhan; Gilles Gosselin; Jean-Pierre Sommadossi
Synthesis of beta-L-2'-deoxythymidine (L-dT).
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2006;Chapter 14():Unit 14.3.
2005: Julien Gagneron; Gilles Gosselin; Christophe Mathé
Synthesis of nucleoside analogues bearing the five naturally occurring nucleic acid bases built on a 2-oxabicylo[3.1.0]hexane scaffold.
The Journal of organic chemistry 2005;70(17):6891-7.
2005: R Bazzanini; Marie-Hélène Gouy; Suzanne Peyrottes; Gilles Gosselin; Christian Périgaud; Stefano Manfredini
Synthetic approaches to a mononucleotide prodrug of cytarabine.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1635-49.
2005: Claire Pierra; Samira Benzaria; A Amador; A Moussa; Sandrine Mathieu; Richard Storer; Gilles Gosselin
Nm 283, an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):767-70.
2005: J C Meillon; L Griffe; Richard Storer; Gilles Gosselin
Rapid access to 2'-branched-carbocyclic nucleosides and their 4'-epimers from 2-alkyl-cyclopentene-1-ones.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):695-9.
2005: David Dukhan; F Leroy; Jérôme Peyronnet; E Bosc; D Chaves; M Durka; Richard Storer; Paolo La Colla; F Seela; Gilles Gosselin
Synthesis of 5-aza-7-deazaguanine nucleoside derivatives as potential anti-flavivirus agents.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):671-4.
2005: F Leroy; David Dukhan; M Durka; D Chaves; N Bragnier; Richard Storer; Gilles Gosselin
Synthesis of 2'-C-methyl-beta-D-ribofuranosylimidazo [4,5-d]-pyridazine derivatives (2-aza-3-deazapurine nucleoside analogues).
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):667-9.
2005: David Dukhan; E Bosc; Jérôme Peyronnet; Richard Storer; Gilles Gosselin
Synthesis of 2'-C-methyl-4'-thio ribonucleosides.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):577-80.
2005: Julien Gagneron; Gilles Gosselin; Christophe Mathé
Synthesis and study of conformationally restricted 3'-deoxy-3',4'-exo-methylene nucleoside analogues.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):383-5.
2004: Claire Pierra; Samira Benzaria; David Dukhan; Anna Giulia Loi; Paolo La Colla; Edward Bridges; John Mao; David Standring; Jean-Pierre Sommadossi; Gilles Gosselin
Synthesis, physicochemical and pharmacokinetic studies of potential prodrugs of beta-L-2'-deoxycytidine, a selective and specific anti-HBV agent.
Antiviral chemistry & chemotherapy 2004;15(5):269-79.
2004: Béatrice Roy; Annalisa Verri; Andrea Lossani; Silvio Spadari; Federico Focher; Anne-Marie Aubertin; Gilles Gosselin; Christophe Mathé; Christian Périgaud
Enantioselectivity of ribonucleotide reductase: a first study using stereoisomers of pyrimidine 2'-azido-2'-deoxynucleosides.
Biochemical pharmacology 2004;68(4):711-8.
2004: Suzanne Peyrottes; David Egron; Isabelle Lefebvre; Gilles Gosselin; Jean-Louis Imbach; Christian Périgaud
SATE pronucleotide approaches: an overview.
Mini reviews in medicinal chemistry 2004;4(4):395-408.
2004: Wolfgang H G Laux; Praveen Pande; Ilana Shoshani; Junyuan Gao; Valérie Boudou-Vivet; Gilles Gosselin; Roger A Johnson
Pro-nucleotide inhibitors of adenylyl cyclases in intact cells.
The Journal of biological chemistry 2004;279(14):13317-32.
2004: Valérie Gagnard; Alain Leydet; Alain Morère; Jean-Louis Montero; Isabelle Lefèbvre; Gilles Gosselin; Christophe Pannecouque; Erick De Clercq
Synthesis and in vitro evaluation of S-acyl-3-thiopropyl prodrugs of Foscarnet.
Bioorganic & medicinal chemistry 2004;12(6):1393-402.
2003: David Egron; Christian Périgaud; Gilles Gosselin; Anne-Marie Aubertin; Abdesslem Faraj; Majid Sélouane; Denis Postel; Christophe Len
1,3-dihydrobenzo[c]furan nucleoside analogues: additional studies of the thymine derivative.
Bioorganic & medicinal chemistry letters 2003;13(24):4473-5.
2003: Frédéric Jeannot; Gilles Gosselin; Christophe Mathé
Synthesis and studies of 3'-C-trifluoromethyl-beta-D-ribonucleosides bearing the five naturally occurring nucleic acid bases.
Nucleosides, nucleotides & nucleic acids 2003;22(12):2195-202.
2003: Evelina Colacino; Giovanni Sindona; Gilles Gosselin; Christophe Mathé
Synthesis and biological evaluation of some 5-nitro- and 5-amino derivatives of 2'-deoxycytidine, 2',3'-dideoxyuridine, and 2',3'-dideoxycytidine.
Nucleosides, nucleotides & nucleic acids 2003;22(11):2013-26.
2003: David Egron; Jean-Louis Imbach; Gilles Gosselin; Anne-Marie Aubertin; Christian Périgaud
S-acyl-2-thioethyl phosphoramidate diester derivatives as mononucleotide prodrugs.
Journal of medicinal chemistry 2003;46(21):4564-71.
2003: Frédéric Jeannot; Gilles Gosselin; Christophe Mathé
Synthesis and antiviral evaluation of 2'-deoxy-2'-C-trifiuoromethyl beta-D-ribonucleoside analogues bearing the five naturally occurring nucleic acid bases.
Organic & biomolecular chemistry 2003;1(12):2096-102.
2003: Samira Benzaria; Claire Pierra; D Bardiot; Erika Cretton-Scott; Edward Bridges; X J Zhou; David Standring; Gilles Gosselin
Monoval-LdC: efficient prodrug of 2'-deoxy-beta-L-cytidine (L-dC), a potent and selective anti-HBV agent.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1003-6.
2003: Christophe Len; Abdelmajid Selouane; Denis Postel; Pierre Villa; Anne-Marie Aubertin; David Egron; Gilles Gosselin; Christian Périgaud
Synthesis, stability, and biological evaluation of 1,3-dihydrobenzo[c]furan analogue of d4T and its SATE pronucleotide.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):943-5.
2003: Gaëlle Coussot; Isabelle Lefebvre; D Dimalta; Suzanne Peyrottes; A Pompon; Gilles Gosselin; Christian Périgaud
SATE (aryl) phosphotriester series. II. Stability studies and physicochemical parameters.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):907-9.
2003: Suzanne Peyrottes; Gilles Gosselin; Anne-Marie Aubertin; Christian Périgaud
SATE (aryl) phosphotriester series. I. Synthesis and biological evaluation.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):903-5.
2003: Anne Jochum; N Schlienger; Gilles Gosselin; Jean-Louis Imbach; Anne-Marie Aubertin; Christian Périgaud
Mononucleoside SATE glucosyl phosphorothiolates as a new series of pronucleotides.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):899-901.
2003: David Egron; Jean-Louis Imbach; Gilles Gosselin; Anne-Marie Aubertin; Christian Périgaud
Investigations of nucleoside H-phosphonamidate in the design of nucleotide prodrug.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):895-7.
2003: Arnaud Marchand; Christophe Mathé; Gilles Gosselin
Synthesis and antiviral evaluation of beta-D- and beta-L-pentofuranonucleoside derivatives bearing 5-trifluoromethylcytosine as the base.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):861-3.
2003: Frédéric Jeannot; Gilles Gosselin; Christophe Mathé
2'-Deoxy-2'-C-trifluoromethyl beta-D-ribonucleoside analogues: synthesis and antiviral evaluations.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):857-9.
2003: JF Griffon; David Dukhan; Claire Pierra; Samira Benzaria; Anna Giulia Loi; Paolo La Colla; Jean-Pierre Sommadossi; Gilles Gosselin
4'-C-methyl-beta-D-ribofuranosyl purine and pyrimidine nucleosides revisited.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):707-9.
2003: Christophe Mathé; Thierry Lioux; Gilles Gosselin
Synthesis and biological evaluation of beta-D-pentofuranonucleoside derivatives of 2-azidoadenine and 6-azidopurines.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):605-9.
2003: Suzanne Peyrottes; Gaëlle Coussot; Isabelle Lefebvre; Jean-Louis Imbach; Gilles Gosselin; Anne-Marie Aubertin; Christian Périgaud
S-acyl-2-thioethyl aryl phosphotriester derivatives of AZT: synthesis, antiviral activity, and stability study.
Journal of medicinal chemistry 2003;46(5):782-93.
2002: Frédéric Jeannot; Gilles Gosselin; David Standring; Martin Bryant; Jean-Pierre Sommadossi; Anna Giulia Loi; Paolo La Colla; Christophe Mathé
Synthesis and studies of 3'-C-trifluoromethyl nucleoside analogues bearing adenine or cytosine as the base.
Bioorganic & medicinal chemistry 2002;10(10):3153-61.
2002: B Hernandez-Santiago; L Placidi; Erika Cretton-Scott; Abdesslem Faraj; Edward Bridges; ML Bryant; J Rodriguez-Orengo; Jean-Louis Imbach; Gilles Gosselin; Claire Pierra; David Dukhan; Jean-Pierre Sommadossi
Pharmacology of beta-L-thymidine and beta-L-2'-deoxycytidine in HepG2 cells and primary human hepatocytes: relevance to chemotherapeutic efficacy against hepatitis B virus.
Antimicrobial agents and chemotherapy 2002;46(6):1728-33.
2002: Bettina Gröschel; Jindrich Cinatl; Christian Périgaud; Gilles Gosselin; JL Imbach; Hans Wilhelm Doerr; J Cinatl
S-acyl-2-thioethyl (SATE) pronucleotides are potent inhibitors of HIV-1 replication in T-lymphoid cells cross-resistant to deoxycytidine and thymidine analogs.
Antiviral research 2002;53(2):143-52.
2002: David Egron; Christian Périgaud; Gilles Gosselin; Anne-Marie Aubertin; Hiroyuki Gatanaga; Hiroaki Mitsuya; Jiri Zemlicka; Jean-Louis Imbach
Increase of the adenallene anti-HIV activity in cell culture using its bis(tBuSATE) phosphotriester derivative.
Bioorganic & medicinal chemistry letters 2002;12(2):265-6.
2001: David Egron; AA Arzumanov; NB Dyatkina; Anne-Marie Aubertin; Jean-Louis Imbach; Gilles Gosselin; AA Krayevsky; Christian Périgaud
Synthesis, anti-HIV activity, and stability studies of 5'-phosphorofluoridate derivatives of AZT.
Bioorganic chemistry 2001;29(6):333-44.
2001: T Beltran; David Egron; A Pompon; Isabelle Lefebvre; Christian Périgaud; Gilles Gosselin; Anne-Marie Aubertin; Jean-Louis Imbach
Rational design of a new series of pronucleotide.
Bioorganic & medicinal chemistry letters 2001;11(13):1775-7.
2001: Suzanne Peyrottes; C Périgau; Anne-Marie Aubertin; Gilles Gosselin; Jean-Louis Imbach
Influence of a Calpha-substitution on the S-pivaloyl-2-thioethyl chain on the anti-HIV activity and stability of the resulting zidovudine mononucleoside phosphotriester.
Antiviral chemistry & chemotherapy 2001;12(4):223-32.
2001: Raul Salvetti; Arnaud Marchand; Massimo Pregnolato; Annalisa Verri; Silvio Spadari; Federico Focher; M Briant; Jean-Pierre Sommadossi; Christophe Mathé; Gilles Gosselin
5-(Trifluoromethyl)-beta-l-2'-deoxyuridine, the L-enantiomer of trifluorothymidine: stereospecific synthesis and antiherpetic evaluations.
Bioorganic & medicinal chemistry 2001;9(7):1731-8.
2001: JF Griffon; Christophe Mathé; Abdesslem Faraj; Anne-Marie Aubertin; E De Clercq; J Balzarini; Jean-Pierre Sommadossi; Gilles Gosselin
Stereospecific synthesis and biological evaluations of beta-L-pentofuranonucleoside derivatives of 5-fluorouracil and 5-fluorocytosine.
European journal of medicinal chemistry 2001;36(5):447-60.
2001: L Placidi; Michel De Meo; Gilles Gosselin; Jean-Louis Imbach; ML Bryant; G Dumenil; Jean-Pierre Sommadossi
Evaluation of the mutagenic and genotoxic activities of anti-hepatitis B analogs of beta-L-adenosine by the Ames test and the Comet assay.
Antiviral research 2001;50(2):139-45.
2001: Gaëlle Coussot; I Lefebvre-Tournier; L Hollecker; Gilles Gosselin; Jean-Louis Imbach; A Pompon
Simultaneous HPLC analysis of hydrophobic prodrugs and their hydrophilic metabolites in biological media without sample preparation. Application to the biotransformation studies of pronucleotides derived from 5-fluorouracil.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):855-8.
2001: G Gaubert; Gilles Gosselin; S Eriksson; Alberto Vita; G Maury
Unnatural enantiomers of 5-azacytidine analogues: syntheses and enzymatic properties.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):837-40.
2001: Frédéric Jeannot; Christophe Mathé; Gilles Gosselin
Synthesis and antiviral evaluation of 3'-C-trifluoromethyl nucleoside derivatives bearing adenine as the base.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):755-8.
2001: David Egron; Christian Périgaud; Gilles Gosselin; Anne-Marie Aubertin; Jean-Louis Imbach
Synthesis and study of a new series of phosphoramidate derivatives as mononucleotide prodrugs.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):751-4.
2001: ML Bryant; Edward Bridges; L Placidi; Abdesslem Faraj; Anna Giulia Loi; Claire Pierra; David Dukhan; Gilles Gosselin; Jean-Louis Imbach; B Hernandez; A Juodawlkis; Bud C Tennant; Brent E Korba; P Cote; Erika Cretton-Scott; Ray F Schinazi; Jean-Pierre Sommadossi
Anti-HBV specific beta-L-2'-deoxynucleosides.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):597-607.
2001: Suzanne Peyrottes; N Schlienger; T Beltran; Isabelle Lefebvre; A Pompon; Gilles Gosselin; Anne-Marie Aubertin; Jean-Louis Imbach; Christian Périgaud
Design of new mononucleotide prodrugs: aryl (SATE) phosphotriester derivatives.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):315-21.
2001: Raul Salvetti; Massimo Pregnolato; Annalisa Verri; Federico Focher; Silvio Spadari; Arnaud Marchand; Christophe Mathé; Gilles Gosselin
Synthesis and in vitro activity of D- and L-enantiomers of 5-(trifluoromethyl)uracil nucleoside derivatives.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):1123-5.
2001: V Boudou-Vivet; Christophe Mathé; Gilles Gosselin
Synthesis and antiviral evaluation of C-4-hydrazide derivatives of 2',3'-dideoxycytidine.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):1029-32.
2001: giovanni maga; Ulrich Hübscher; Massimo Pregnolato; Daniela Ubiali; Gilles Gosselin; Silvio Spadari
Potentiation of inhibition of wild-type and mutant human immunodeficiency virus type 1 reverse transcriptases by combinations of nonnucleoside inhibitors and d- and L-(beta)-dideoxynucleoside triphosphate analogs.
Antimicrobial agents and chemotherapy 2001;45(4):1192-200.
2001: Daniela Salvatori; Silvia Vincenzetti; G Maury; Gilles Gosselin; G Gaubert; Alberto Vita
Maedi-visna virus, a model for in vitro testing of potential anti-HIV drugs.
Comparative immunology, microbiology and infectious diseases 2001;24(2):113-22.
2001: Manijeh Shafiee; Sven Deferme; A L Villard; David Egron; Gilles Gosselin; Jean-Louis Imbach; Thierry Lioux; A Pompon; S Varray; A M Aubertin; Guy Van den Mooter; Renaat Kinget; Christian Périgaud; Patrick Augustijns
New bis(SATE) prodrug of AZT 5'-monophosphate: in vitro anti-HIV activity, stability, and potential oral absorption.
Journal of pharmaceutical sciences 2001;90(4):448-63.
2001: David Standring; Edward Bridges; L Placidi; Abdesslem Faraj; Anna Giulia Loi; Claire Pierra; David Dukhan; Gilles Gosselin; Jean-Louis Imbach; B Hernandez; A Juodawlkis; Bud C Tennant; Brent E Korba; P Cote; Erika Cretton-Scott; Ray F Schinazi; M Myers; ML Bryant; Jean-Pierre Sommadossi
Antiviral beta-L-nucleosides specific for hepatitis B virus infection.
Antiviral chemistry & chemotherapy 2001;12 Suppl 1():119-29.
2001: ML Bryant; Edward Bridges; L Placidi; Abdesslem Faraj; Anna Giulia Loi; Claire Pierra; David Dukhan; Gilles Gosselin; Jean-Louis Imbach; B Hernandez; A Juodawlkis; Bud C Tennant; Brent E Korba; P Cote; P Marion; Erika Cretton-Scott; Ray F Schinazi; Jean-Pierre Sommadossi
Antiviral L-nucleosides specific for hepatitis B virus infection.
Antimicrobial agents and chemotherapy 2001;45(1):229-35.
2000: N Schlienger; Suzanne Peyrottes; Tarek Kassem; Jean-Louis Imbach; Gilles Gosselin; Anne-Marie Aubertin; Christian Périgaud
S-Acyl-2-thioethyl aryl phosphotriester derivatives as mononucleotide prodrugs.
Journal of medicinal chemistry 2000;43(23):4570-4.
2000: Christophe Mathé; Gilles Gosselin
Synthesis and antiviral evaluation of the beta-L-enantiomers of some thymine 3'-deoxypentofuranonucleoside derivatives.
Nucleosides, nucleotides & nucleic acids 2000;19(10-12):1517-30.
2000: Abdesslem Faraj; A M El Alaoui; Gilles Gosselin; Jean-Louis Imbach; C Morrow; Jean-Pierre Sommadossi
Effects of beta-L-3'-azido-3'-deoxythymidine 5'-triphosphate on host and viral DNA polymerases.
Antiviral research 2000;47(2):97-102.
2000: X Tan; F Douglas Boudinot; Chung (David) K. Chu; David Egron; C Perigaud; Gilles Gosselin; Jean-Louis Imbach
Pharmacokinetics of bis(t-butyl-SATE)-AZTMP, a bispivaloylthioethyl prodrug for intracellular delivery of zidovudine monophosphate, in mice.
Antiviral chemistry & chemotherapy 2000;11(3):203-11.
2000: L Placidi; Erika Cretton-Scott; Gilles Gosselin; Claire Pierra; Ray F Schinazi; Jean-Louis Imbach; Mahmoud el Kouni; Jean-Pierre Sommadossi
Intracellular metabolism of beta-L-2',3'-dideoxyadenosine: relevance to its limited antiviral activity.
Antimicrobial agents and chemotherapy 2000;44(4):853-8.
2000: Claire Pierra; Jean-Louis Imbach; Erick De Clercq; J Balzarini; A Van Aerschot; P Herdewijn; Abdesslem Faraj; Anna Giulia Loi; Jean-Pierre Sommadossi; Gilles Gosselin
Synthesis and antiviral evaluation of some beta-L-2', 3'-dideoxy-5-chloropyrimidine nucleosides and pronucleotides.
Antiviral research 2000;45(3):169-83.
2000: V V Sosunov; Fanny Santamaria; Lyubov Victorova; Gilles Gosselin; Bernard Rayner; AA Krayevsky
Stereochemical control of DNA biosynthesis.
Nucleic acids research 2000;28(5):1170-5.
2000: Christophe Mathé; Jean-Louis Imbach; Gilles Gosselin
1,2-di-O-acetyl-5-O-benzoyl-3-deoxy-L-erythro-pentofuran ose, a convenient precursor for the stereospecific synthesis of nucleoside analogues with the unnatural beta-L-configuration.
Carbohydrate research 2000;323(1-4):226-9.
2000: LT Martin; Erika Cretton-Scott; L Placidi; Abdesslem Faraj; Anna Giulia Loi; Ray F Schinazi; H M McClure; Gilles Gosselin; Jean-Louis Imbach; Jean-Pierre Sommadossi
In vitro and in vivo metabolism and pharmacokinetics of bis [(t-butyl)-S-acyl-2-thioethyl]-beta-L-2',3'-dideoxy-5-fluorocytidine monophosphate.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):481-99.
2000: Arnaud Marchand; Christophe Mathé; Jean-Louis Imbach; Gilles Gosselin
Synthesis and antiviral evaluation of unnatural beta-L-enantiomers of 3'-fluoro- and 3'-azido-2',3'-dideoxyguanosine derivatives.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):205-17.
1999: I Shoshani; Wolfgang H G Laux; Christian Périgaud; Gilles Gosselin; Roger A Johnson
Inhibition of adenylyl cyclase by acyclic nucleoside phosphonate antiviral agents.
The Journal of biological chemistry 1999;274(49):34742-4.
1999: I Shoshani; V Boudou; Claire Pierra; Gilles Gosselin; R A Johnson
Enzymatic synthesis of unlabeled and beta-(32)P-labeled beta-L-2', 3'-dideoxyadenosine-5'-triphosphate as a potent inhibitor of adenylyl cyclases and its use as reversible binding ligand.
The Journal of biological chemistry 1999;274(49):34735-41.
1999: V Boudou; Jean-Louis Imbach; Gilles Gosselin
Synthesis and biological evaluation of 9-(beta-L-arabinofuranosyl)adenine.
Nucleosides & nucleotides 1999;18(11-12):2463-73.
1999: G Gaubert; Gilles Gosselin; V Boudou; Jean-Louis Imbach; S Eriksson; G Maury
Low enantioselectivities of human deoxycytidine kinase and human deoxyguanosine kinase with respect to 2'-deoxyadenosine, 2'-deoxyguanosine and their analogs.
Biochimie 1999;81(11):1041-7.
1999: I Kers; J Stawiński; JL Girardet; Jean-Louis Imbach; Christian Périgaud; Gilles Gosselin; A M Aubertin
Synthesis and anti-retroviral activity of O,O'-bis(3'-azido-2',3'-dideoxythymidin-5'-yl) phosphoramidate derivatives.
Nucleosides & nucleotides 1999;18(10):2317-25.
1999: N Schlienger; Suzanne Peyrottes; Anne-Marie Aubertin; Gilles Gosselin; Jean-Louis Imbach; Christian Périgaud
New series of mixed pronucleotides. Synthesis and anti-HIV activities of mononucleoside phenyl SATE phosphotriesters.
Nucleosides & nucleotides 1999;18(4-5):1025-6.
1999: Anna Giulia Loi; Abdesslem Faraj; Claire Pierra; Gilles Gosselin; Jean-Louis Imbach; S A Locarnini; E V Groman; Ray F Schinazi; Jean-Pierre Sommadossi
Comparison of anti-HBV activity of beta-D- and beta-L-DDA-5'monophosphate prodrugs and effectiveness in combination with lamivudine.
Nucleosides & nucleotides 1999;18(4-5):1005-6.
1999: Wolfgang H G Laux; Christian Périgaud; Jean-Louis Imbach; Gilles Gosselin
Synthesis of new PMEA diphosphate mimics.
Nucleosides & nucleotides 1999;18(4-5):1003-4.
1999: M Lannuzel; David Egron; Jean-Louis Imbach; Gilles Gosselin; Christian Périgaud
Synthesis of the tBuSATE pronucleotide of AZT by two different synthetic approaches.
Nucleosides & nucleotides 1999;18(4-5):1001-2.
1999: I Kers; JL Girardet; Gilles Gosselin; C Perigaud; Jean-Louis Imbach; Jacek Stawinski
Synthesis and in vitro antiviral activity of some symmetrical phosphoramidate dimers of AZT.
Nucleosides & nucleotides 1999;18(4-5):993-4.
1999: Abdesslem Faraj; L Placidi; C Perigaud; Erika Cretton-Scott; Gilles Gosselin; LT Martin; Claire Pierra; Ray F Schinazi; Jean-Louis Imbach; Jean-Pierre Sommadossi
Intracellular metabolism of beta-L-ddAMP-bis(tbutylSATE), a potent inhibitor of hepatitis B virus replication.
Nucleosides & nucleotides 1999;18(4-5):987-8.
1999: David Egron; AA Arzumanov; NB Dyatkina; AA Krayevsky; Jean-Louis Imbach; Anne-Marie Aubertin; Gilles Gosselin; Christian Périgaud
Synthesis, anti-HIV activity and stability studies of 3'-azido-2',3'-dideoxythymidine 5'-fluorophosphate.
Nucleosides & nucleotides 1999;18(4-5):983-4.
1999: David Egron; Christian Périgaud; Gilles Gosselin; Anne-Marie Aubertin; Jean-Louis Imbach
Synthesis and anti-HIV activity of some S-acyl-2-thioethyl (SATE) phosphoramidate derivatives of 3'-azido-2',3'-dideoxythymidine.
Nucleosides & nucleotides 1999;18(4-5):981-2.
1999: T Beltran; David Egron; Isabelle Lefebvre; Christian Périgaud; A Pompon; Gilles Gosselin; Anne-Marie Aubertin; Jean-Louis Imbach
Anti-HIV pronucleotides: SATE versus phenyl as a protecting group of AZT phosphoramidate derivatives.
Nucleosides & nucleotides 1999;18(4-5):973-5.
1999: R Bazzanini; Stefano Manfredini; Elisa Durini; Bettina Gröschel; Jindrich Cinatl; Jan Balzarini; Erik De Clercq; JL Imbach; Christian Périgaud; Gilles Gosselin
Prodrugs of Ara-CMP and Ara-AMP with a S-acyl-2-thioethyl (SATE) biolabile phosphate protecting group: synthesis and biological evaluation.
Nucleosides & nucleotides 1999;18(4-5):971-2.
1999: Bettina Gröschel; N Himmel; Jindrich Cinatl; Christian Périgaud; Gilles Gosselin; JL Imbach; Hans Wilhelm Doerr; J Cinatl
ddC- and 3TC-bis(SATE) monophosphate prodrugs overcome cellular resistance mechanisms to HIV-1 associated with cytidine kinase deficiency.
Nucleosides & nucleotides 1999;18(4-5):921-6.
1999: Annalisa Verri; Alessandra Montecucco; Gilles Gosselin; V Boudou; Silvio Spadari; Jean-Louis Imbach; Federico Focher
Interaction of beta-L-adenosine-5'-triphosphate (L-ATP) with human deoxycytidine kinase, human DNA primase and T4 DNA ligase: does the chance direct enzymatic enantioselectivity?
Nucleosides & nucleotides 1999;18(4-5):867-9.
1999: AA Krayevsky; NB Dyatkina; DG Semizarov; Lyubov Victorova; Elena A Shirokova; F Theil; MJ von Janta-Lipinski; Gilles Gosselin; Jean-Louis Imbach
Reasons and limits of substrate activity of modified L-dNTP in DNA biosynthesis.
Nucleosides & nucleotides 1999;18(4-5):863-4.
1999: G Gaubert; Gilles Gosselin; Jean-Louis Imbach; S Eriksson; G Maury
Derivatives of L-adenosine and L-guanosine as substrates for human deoxycytidine kinase.
Nucleosides & nucleotides 1999;18(4-5):857-60.
1999: R A Johnson; I Shoshani; C Dessauer; Gilles Gosselin
Enzymatic preparation of 32P-labeled beta-L-2',3',-dd-5'ATP and its use as a high-affinity, conformation-specific ligand for labeling adenylyl cyclases.
Nucleosides & nucleotides 1999;18(4-5):839-42.
1999: giovanni maga; Mario Amacker; Ulrich Hübscher; Gilles Gosselin; Jean-Louis Imbach; Christophe Mathé; Abdesslem Faraj; Jean-Pierre Sommadossi; Silvio Spadari
Structural determinants of HIV-1 reverse transcriptase stereoselectivity towards (beta)-L-deoxy- and dideoxy-pyrimidine nucleoside triphosphates: molecular basis for the combination of L-dideoxynucleoside analogs with non-nucleoside inhibitors in anti HIV chemotherapy.
Nucleosides & nucleotides 1999;18(4-5):795-805.
1999: Manijeh Shafiee; Gilles Gosselin; Jean-Louis Imbach; S Eriksson; G Maury
Synthesis of new fluorescent nucleoside analogues and application to the study of human deoxycytidine kinase.
Nucleosides & nucleotides 1999;18(4-5):717-9.
1999: Claire Pierra; Gilles Gosselin; Jean-Pierre Sommadossi; Abdesslem Faraj; Erick De Clercq; J Balzarini; Jean-Louis Imbach
Stereospecific synthesis and antiviral activities of beta-L-2',3'-dideoxy-5-chloropyrimidine nucleoside derivatives.
Nucleosides & nucleotides 1999;18(4-5):643-4.
1999: LT Martin; Erika Cretton-Scott; Ray F Schinazi; XJ Zhou; H M McClure; C Mathe; Gilles Gosselin; Jean-Louis Imbach; Jean-Pierre Sommadossi
Pharmacokinetics of beta-L-2',3'-dideoxy-5-fluorocytidine in rhesus monkeys.
Antimicrobial agents and chemotherapy 1999;43(4):920-4.
1999: giovanni maga; Mario Amacker; Ulrich Hübscher; Gilles Gosselin; Jean-Louis Imbach; Christophe Mathé; Abdesslem Faraj; Jean-Pierre Sommadossi; Silvio Spadari
Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs.
Nucleic acids research 1999;27(4):972-8.
1999: Annalisa Verri; Alessandra Montecucco; Gilles Gosselin; V Boudou; Jean-Louis Imbach; Silvio Spadari; Federico Focher
L-ATP is recognized by some cellular and viral enzymes: does chance drive enzymic enantioselectivity?
The Biochemical journal 1999;337 ( Pt 3)():585-90.
1999: Christian Périgaud; Gilles Gosselin; JL Girardet; B E Korba; Jean-Louis Imbach
The S-acyl-2-thioethyl pronucleotide approach applied to acyclovir: part I. Synthesis and in vitro anti-hepatitis B virus activity of bis(S-acyl-2-thioethyl)phosphotriester derivatives of acyclovir.
Antiviral research 1999;40(3):167-78.
1998: N Schlienger; T Beltran; Christian Périgaud; Isabelle Lefebvre; A Pompon; Anne-Marie Aubertin; Gilles Gosselin; Jean-Louis Imbach
Rational design of a new series of mixed anti-HIV pronucleotides.
Bioorganic & medicinal chemistry letters 1998;8(21):3003-6.
1998: Manijeh Shafiee; JF Griffon; Gilles Gosselin; A Cambi; Silvia Vincenzetti; Alberto Vita; S Eriksson; Jean-Louis Imbach; G Maury
A comparison of the enantioselectivities of human deoxycytidine kinase and human cytidine deaminase.
Biochemical pharmacology 1998;56(9):1237-42.
1998: David Egron; Isabelle Lefebvre; Christian Périgaud; T Beltran; A Pompon; Gilles Gosselin; Anne-Marie Aubertin; Jean-Louis Imbach
Anti-HIV pronucleotides: decomposition pathways and correlation with biological activities.
Bioorganic & medicinal chemistry letters 1998;8(9):1045-50.
1998: Pieter Annaert; Gilles Gosselin; A Pompon; S Benzaria; G Valette; Jean-Louis Imbach; Lieve Naesens; Sigrid Hatse; Erik De Clercq; Guy Van den Mooter; Renaat Kinget; Patrick Augustijns
Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers.
Pharmaceutical research 1998;15(2):239-45.
1998: Chris Meier; Anne-Marie Aubertin; M de Monte; Abdesslem Faraj; Jean-Pierre Sommadossi; Christian Périgaud; Jean-Louis Imbach; Gilles Gosselin
Synthesis and antiviral evaluation of SATE-foscarnet prodrugs and new foscarnet-AZT conjugates.
Antiviral chemistry & chemotherapy 1998;9(1):41-52.
1997: H Pélicano; Claire Pierra; S Eriksson; Gilles Gosselin; Jean-Louis Imbach; G Maury
Enzymatic properties of the unnatural beta-L-enantiomers of 2',3'-dideoxyadenosine and 2',3'-didehydro-2',3'-dideoxyadenosine.
Journal of medicinal chemistry 1997;40(24):3969-73.
1997: DG Semizarov; AA Arzumanov; NB Dyatkina; A Meyer; S Vichier-Guerre; Gilles Gosselin; Bernard Rayner; Jean-Louis Imbach; AA Krayevsky
Stereoisomers of deoxynucleoside 5'-triphosphates as substrates for template-dependent and -independent DNA polymerases.
The Journal of biological chemistry 1997;272(14):9556-60.
1997: LT Martin; Abdesslem Faraj; Ray F Schinazi; Gilles Gosselin; C Mathe; Jean-Louis Imbach; Jean-Pierre Sommadossi
Effect of stereoisomerism on the cellular pharmacology of beta-enantiomers of cytidine analogs in Hep-G2 cells.
Biochemical pharmacology 1997;53(1):75-87.
1997: Annalisa Verri; Federico Focher; G Priori; Gilles Gosselin; Jean-Louis Imbach; Massimo L Capobianco; A Garbesi; Silvio Spadari
Lack of enantiospecificity of human 2'-deoxycytidine kinase: relevance for the activation of beta-L-deoxycytidine analogs as antineoplastic and antiviral agents.
Molecular pharmacology 1997;51(1):132-8.
1996: S Benzaria; H Pélicano; R Johnson; G Maury; Jean-Louis Imbach; A M Aubertin; G Obert; Gilles Gosselin
Synthesis, in vitro antiviral evaluation, and stability studies of bis(S-acyl-2-thioethyl) ester derivatives of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) as potential PMEA prodrugs with improved oral bioavailability.
Journal of medicinal chemistry 1996;39(25):4958-65.
1996: L Cui; Ray F Schinazi; Gilles Gosselin; Jean-Louis Imbach; Chung (David) K. Chu; RF Rando; G R Revankar; Jean-Pierre Sommadossi
Effect of beta-enantiomeric and racemic nucleoside analogues on mitochondrial functions in HepG2 cells. Implications for predicting drug hepatotoxicity.
Biochemical pharmacology 1996;52(10):1577-84.
1996: Mahmoud el Kouni; Fardos N M Naguib; R P Panzica; B A Otter; S H Chu; Gilles Gosselin; Chung (David) K. Chu; Ray F Schinazi; Y F Shealy; N Goudgaon; A A Ozerov; T Ueda; M H Iltzsch
Effects of modifications in the pentose moiety and conformational changes on the binding of nucleoside ligands to uridine phosphorylase from Toxoplasma gondii.
Biochemical pharmacology 1996;51(12):1687-700.
1996: G Valette; A Pompon; J L Girardet; Loredana Cappellacci; Palmarisa Franchetti; Mario Grifantini; Paolo La Colla; Anna Giulia Loi; Christian Périgaud; Gilles Gosselin; Jean-Louis Imbach
Decomposition pathways and in vitro HIV inhibitory effects of isoddA pronucleotides: toward a rational approach for intracellular delivery of nucleoside 5'-monophosphates.
Journal of medicinal chemistry 1996;39(10):1981-90.
1996: C Thumann-Schweitzer; Gilles Gosselin; Christian Périgaud; S Benzaria; J L Girardet; Isabelle Lefebvre; Jean-Louis Imbach; A Kirn; A M Aubertin
Anti-human immunodeficiency virus type 1 activities of dideoxynucleoside phosphotriester derivatives in primary monocytes/macrophages.
Research in virology 1996;147(2-3):155-63.
1996: Abdesslem Faraj; Ray F Schinazi; M Y Xie; Gilles Gosselin; C Perigaud; Jean-Louis Imbach; Jean-Pierre Sommadossi
Selective protection of toxicity of 2',3'-dideoxypyrimidine nucleoside analogs by beta-D-uridine in human granulocyte-macrophage progenitor cells.
Antiviral research 1996;29(2-3):261-7.
1996: Gilles Gosselin; J L Girardet; Christian Périgaud; S Benzaria; Isabelle Lefebvre; N Schlienger; A Pompon; Jean-Louis Imbach
New insights regarding the potential of the pronucleotide approach in antiviral chemotherapy.
Acta biochimica Polonica 1996;43(1):196-208.
1995: Isabelle Lefebvre; Christian Périgaud; A Pompon; A M Aubertin; J L Girardet; A Kirn; Gilles Gosselin; Jean-Louis Imbach
Mononucleoside phosphotriester derivatives with S-acyl-2-thioethyl bioreversible phosphate-protecting groups: intracellular delivery of 3'-azido-2',3'-dideoxythymidine 5'-monophosphate.
Journal of medicinal chemistry 1995;38(20):3941-50.
1994: Abdesslem Faraj; L A Agrofoglio; J K Wakefield; Sylvia A McPherson; Casey D Morrow; Gilles Gosselin; C Mathe; Jean-Louis Imbach; Ray F Schinazi; Jean-Pierre Sommadossi
Inhibition of human immunodeficiency virus type 1 reverse transcriptase by the 5'-triphosphate beta enantiomers of cytidine analogs.
Antimicrobial agents and chemotherapy 1994;38(10):2300-5.
1994: Ray F Schinazi; Gilles Gosselin; Abdesslem Faraj; B E Korba; Dennis C Liotta; Chung (David) K. Chu; Christophe Mathé; Jean-Louis Imbach; Jean-Pierre Sommadossi
Pure nucleoside enantiomers of beta-2',3'-dideoxycytidine analogs are selective inhibitors of hepatitis B virus in vitro.
Antimicrobial agents and chemotherapy 1994;38(9):2172-4.
1994: C Perigaud; A M Aubertin; S Benzaria; H Pelicano; J L Girardet; G Maury; Gilles Gosselin; A Kirn; Jean-Louis Imbach
Equal inhibition of the replication of human immunodeficiency virus in human T-cell culture by ddA bis(SATE)phosphotriester and 3'-azido-2',3'-dideoxythymidine.
Biochemical pharmacology 1994;48(1):11-14.
1994: Gilles Gosselin; Ray F Schinazi; Jean-Pierre Sommadossi; Christophe Mathé; M C Bergogne; A M Aubertin; A Kirn; Jean-Louis Imbach
Anti-human immunodeficiency virus activities of the beta-L enantiomer of 2',3'-dideoxycytidine and its 5-fluoro derivative in vitro.
Antimicrobial agents and chemotherapy 1994;38(6):1292-7.
1994: K E Rao; Gilles Gosselin; D Mrani; Christian Périgaud; Jean-Louis Imbach; Christian Bailly; Jean-Pierre Hénichart; P Colson; Claude Houssier; J W Lown
Psoralen--lexitropsin hybrids: DNA sequence selectivity of photoinduced cross-linking from MPE footprinting and exonuclease III stop assay, and mode of binding from electric linear dichroism.
Anti-cancer drug design 1994;9(3):221-37.
1994: Gilles Gosselin; Christophe Mathé; M C Bergogne; A M Aubertin; A Kirn; Ray F Schinazi; Jean-Pierre Sommadossi; Jean-Louis Imbach
Enantiomeric 2',3'-dideoxycytidine derivatives are potent human immunodeficiency virus inhibitors in cell cultures.
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1994;317(1):85-9.
1993: Gilles Gosselin; F Puech; C Génu-Dellac; Jean-Louis Imbach
1,2-Di-O-acetyl-5-O-benzoyl-3-deoxy-3-fluoro-D-xylofuranose. A versatile precursor for the synthesis of 3-deoxy-3-fluoro-beta-D-xylofuranosyl nucleosides as potential antiviral agents.
Carbohydrate research 1993;249(1):1-17.
1993: F Puech; Gilles Gosselin; Isabelle Lefebvre; A Pompon; A M Aubertin; A Kirn; Jean-Louis Imbach
Intracellular delivery of nucleoside monophosphates through a reductase-mediated activation process.
Antiviral research 1993;22(2-3):155-74.
1993: Gilles Gosselin; Christian Périgaud; Isabelle Lefebvre; A Pompon; A M Aubertin; A Kirn; T Szabo; Jacek Stawinski; Jean-Louis Imbach
5'-Hydrogenphosphonates of anti-HIV nucleoside analogues revisited: controversial mode of action.
Antiviral research 1993;22(2-3):143-53.
1993: O Zelphati; G Degols; H Loughrey; Lee Leserman; A Pompon; F Puech; A F Maggio; Jean-Louis Imbach; Gilles Gosselin
Inhibition of HIV-1 replication in cultured cells with phosphorylated dideoxyuridine derivatives encapsulated in immunoliposomes.
Antiviral research 1993;21(3):181-95.
1992: Christian Bailly; P Colson; Claude Houssier; Raymond Houssin; D Mrani; Gilles Gosselin; Jean-Louis Imbach; M J Waring; J W Lown; Jean-Pierre Hénichart
Binding properties and DNA sequence-specific recognition of two bithiazole-linked netropsin hybrid molecules.
Biochemistry 1992;31(35):8349-62.
1991: Frédéric Subra; S Carteau; J Pager; J Paoletti; C Paoletti; Christian Auclair; D Mrani; Gilles Gosselin; Jean-Louis Imbach
Bis(pyrrolecarboxamide) linked to intercalating chromophore oxazolopyridocarbazole (OPC): selective binding to DNA and polynucleotides.
Biochemistry 1991;30(6):1642-50.
1989: Françoise Debart; C Periguad; Gilles Gosselin; D Mrani; B Rayner; P Le Ber; Christian Auclair; J Balzarini; E De Clercq; C Paoletti
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
Journal of medicinal chemistry 1989;32(5):1074-83.
1988: F Puech; Gilles Gosselin; J qalzarini; E De Clercq; Jean-Louis Imbach
Synthesis and biological evaluation of isomeric dinucleoside monophosphates and monomethylphosphonates of 9-beta-D-arabinofuranosyladenine and related analogues.
Journal of medicinal chemistry 1988;31(10):1897-907.
1988: Mahmoud el Kouni; Fardos N M Naguib; S H Chu; S M Cha; T Ueda; Gilles Gosselin; J L Imbach; Y F Shealy; B A Otter
Effect of the N-glycosidic bond conformation and modifications in the pentose moiety on the binding of nucleoside ligands to uridine phosphorylase.
Molecular pharmacology 1988;34(2):104-10.
1987: Gilles Gosselin; M C Bergogne; J De Rudder; E De Clercq; Jean-Louis Imbach
Systematic synthesis and biological evaluation of alpha- and beta-D-lyxofuranosyl nucleosides of the five naturally occurring nucleic acid bases.
Journal of medicinal chemistry 1987;30(6):982-91.
1987: A Pompon; Gilles Gosselin; M C Bergogne; Jean-Louis Imbach
Reversed-phase high-performance liquid chromatography of nucleoside analogues. Simultaneous analysis of anomeric D-xylo- and D-lyxofuranonucleosides and some other D-pentofuranonucleosides.
Journal of chromatography 1987;388(1):113-22.
1986: Gilles Gosselin; M C Bergogne; J de Rudder; E De Clercq; Jean-Louis Imbach
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
Journal of medicinal chemistry 1986;29(2):203-13.