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Enrico Gottardi

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Roberta La Starza; Caterina Matteucci; Paolo Gorello; Lucia Brandimarte; Valentina Pierini; Barbara Crescenzi; Valeria Nofrini; Roberto Rosati; Enrico Gottardi; Giuseppe Saglio; Antonella Santucci; Laura Berchicci; Francesco Arcioni; Brunangelo Falini; Massimo Fabrizio Martelli; Constantina Sambani; Anna Aventin; Cristina Mecucci
NPM1 deletion is associated with gross chromosomal rearrangements in leukemia.
Daniela Cilloni; Aline Renneville; fabienne hermitte; Robert K Hills; Sarah Daly; Jelena V Jovanovic; Enrico Gottardi; Milena Fava; Susanne Schnittger; Tamara Weiss; Barbara Izzo; Josep Nomdedeu; Adrian van der Heijden; Bert A van der Reijden; Joop H Jansen; Vincent H J van der Velden; Hans Ommen; Claude Preudhomme; Giuseppe Saglio; David Grimwade
Real-time quantitative polymerase chain reaction detection of minimal residual disease by standardized WT1 assay to enhance risk stratification in acute myeloid leukemia: a European LeukemiaNet study.
Daniela Cilloni; Francesca Messa; Francesca Arruga; Ilaria Defilippi; Enrico Gottardi; Milena Fava; Sonia Carturan; Renata Catalano; Enrico Bracco; Emanuela Messa; Paolo Nicoli; Daniela Diverio; Miguel A Sanz; giovanni martinelli; Francesco Lo Coco; Giuseppe Saglio
Early prediction of treatment outcome in acute myeloid leukemia by measurement of WT1 transcript levels in peripheral blood samples collected after chemotherapy.

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All Publications

2010: Roberta La Starza; Caterina Matteucci; Paolo Gorello; Lucia Brandimarte; Valentina Pierini; Barbara Crescenzi; Valeria Nofrini; Roberto Rosati; Enrico Gottardi; Giuseppe Saglio; Antonella Santucci; Laura Berchicci; Francesco Arcioni; Brunangelo Falini; Massimo Fabrizio Martelli; Constantina Sambani; Anna Aventin; Cristina Mecucci
NPM1 deletion is associated with gross chromosomal rearrangements in leukemia.
PloS one 2010;5(9):e12855.
2009: Daniela Cilloni; Aline Renneville; fabienne hermitte; Robert K Hills; Sarah Daly; Jelena V Jovanovic; Enrico Gottardi; Milena Fava; Susanne Schnittger; Tamara Weiss; Barbara Izzo; Josep Nomdedeu; Adrian van der Heijden; Bert A van der Reijden; Joop H Jansen; Vincent H J van der Velden; Hans Ommen; Claude Preudhomme; Giuseppe Saglio; David Grimwade
Real-time quantitative polymerase chain reaction detection of minimal residual disease by standardized WT1 assay to enhance risk stratification in acute myeloid leukemia: a European LeukemiaNet study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(31):5195-201.
2008: Daniela Cilloni; Francesca Messa; Francesca Arruga; Ilaria Defilippi; Enrico Gottardi; Milena Fava; Sonia Carturan; Renata Catalano; Enrico Bracco; Emanuela Messa; Paolo Nicoli; Daniela Diverio; Miguel A Sanz; giovanni martinelli; Francesco Lo Coco; Giuseppe Saglio
Early prediction of treatment outcome in acute myeloid leukemia by measurement of WT1 transcript levels in peripheral blood samples collected after chemotherapy.
Haematologica 2008;93(6):921-4.
2008: Giuseppe Saglio; Stefano Ulisciani; Milena Fava; Enrico Gottardi; Daniela Cilloni
Molecular monitoring in patients with chronic myelogenous leukemia.
Current hematologic malignancy reports 2008;3(2):65-71.
2008: Martin C Müller; Philipp Erben; Giuseppe Saglio; Enrico Gottardi; C G Nyvold; T Schenk; T Ernst; S Lauber; J Kruth; Rüdiger Hehlmann; Andreas Hochhaus
Harmonization of BCR-ABL mRNA quantification using a uniform multifunctional control plasmid in 37 international laboratories.
Leukemia 2008;22(1):96-102.
2007: Michele Baccarani; Daniela Cilloni; Michela Rondoni; Emanuela Ottaviani; Francesca Messa; Serena Merante; Mario Tiribelli; Francesco Buccisano; Nicoletta Testoni; Enrico Gottardi; Antonio de Vivo; Emilia Giugliano; Ilaria Iacobucci; Stefania Paolini; Simona Soverini; Gianantonio Rosti; Francesca Rancati; Cinzia Astolfi; Fabrizio Pane; Giuseppe Saglio; giovanni martinelli
The efficacy of imatinib mesylate in patients with FIP1L1-PDGFRalpha-positive hypereosinophilic syndrome. Results of a multicenter prospective study.
Haematologica 2007;92(9):1173-9.
2007: Daniela Cilloni; Francesca Messa; giovanni martinelli; Enrico Gottardi; Francesca Arruga; Ilaria Defilippi; Sonia Carturan; Emanuela Messa; Milena Fava; Emilia Giugliano; Valentina Rosso; Renata Catalano; Serena Merante; P Nicoli; Michela Rondoni; Emanuela Ottaviani; Simona Soverini; Mario Tiribelli; Fabrizio Pane; Michele Baccarani; Giuseppe Saglio
WT1 transcript amount discriminates secondary or reactive eosinophilia from idiopathic hypereosinophilic syndrome or chronic eosinophilic leukemia.
Leukemia 2007;21(7):1442-50.
2007: Jelena V Jovanovic; Joannah Score; Katherine Waghorn; Daniela Cilloni; Enrico Gottardi; Georgia Metzgeroth; Philipp Erben; Helena Popp; Christoph Walz; Andreas Hochhaus; Catherine Roche-Lestienne; Claude Preudhomme; Ellen Solomon; Jane Apperley; Michela Rondoni; Emanuela Ottaviani; giovanni martinelli; Finella Brito-Babapulle; Giuseppe Saglio; Rüdiger Hehlmann; Nicholas C P Cross; Andreas Reiter; David Grimwade
Low-dose imatinib mesylate leads to rapid induction of major molecular responses and achievement of complete molecular remission in FIP1L1-PDGFRA-positive chronic eosinophilic leukemia.
Blood 2007;109(11):4635-40.
2006: Alessandro Morotti; Daniela Cilloni; Marisa Pautasso; Francesca Messa; Francesca Arruga; Ilaria Defilippi; Sonia Carturan; Renata Catalano; Valentina Rosso; A Chiarenza; Riccardo Taulli; Enrico Bracco; Giovanna Rege-Cambrin; Enrico Gottardi; Giuseppe Saglio
NF-kB inhibition as a strategy to enhance etoposide-induced apoptosis in K562 cell line.
American journal of hematology 2006;81(12):938-45.
2006: Paolo Gorello; Giovanni Cazzaniga; F Alberti; Maria Grazia Dell'Oro; Enrico Gottardi; Giorgina Specchia; Giovanni Roti; Roberto Rosati; Massimo F Martelli; Daniela Diverio; Francesco Lo Coco; Andrea Biondi; Giuseppe Saglio; Cristina Mecucci; Brunangelo Falini
Quantitative assessment of minimal residual disease in acute myeloid leukemia carrying nucleophosmin (NPM1) gene mutations.
Leukemia 2006;20(6):1103-8.
2006: Alessandro Morotti; Daniela Cilloni; Francesca Messa; Francesca Arruga; Ilaria Defilippi; Sonia Carturan; Renata Catalano; Valentina Rosso; Annalisa Chiarenza; Chiara Pilatrino; Angelo Guerrasio; Riccardo Taulli; Enrico Bracco; Marisa Pautasso; Daniela Baraban; Enrico Gottardi; Giuseppe Saglio
Valproate enhances imatinib-induced growth arrest and apoptosis in chronic myeloid leukemia cells.
Cancer 2006;106(5):1188-96.
2006: Serena Merante; Merante Serena; Guido Chichino; Chichino Guido; Emanuela Boveri; Boveri Emanuela; Enrico Gottardi; Gottardi Enrico; Simona Soverini; Soverini Simona; Daniela Cilloni; Cilloni Daniela; giovanni martinelli; Martinelli Giovanni
First case of an AIDS patient with systemic mast cell disease associated with FIP1-positive eosinophilia treated with imatinib mesylate therapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(4):e6-7.
2006: Daniela Cilloni; Enrico Gottardi; Giuseppe Saglio
WT1 overexpression in acute myeloid leukemia and myelodysplastic syndromes.
Methods in molecular medicine 2006;125():199-211.
2005: Alessandro Bondi; Paola Valentino; Filomena Daraio; Paolo Porporato; Enrico Gramaglia; Sonia Carturan; Enrico Gottardi; Clara Camaschella; Antonella Roetto
Hepatic expression of hemochromatosis genes in two mouse strains after phlebotomy and iron overload.
Haematologica 2005;90(9):1161-7.
2005: Giovanni Roti; Roberta La Starza; Paolo Gorello; Enrico Gottardi; Barbara Crescenzi; Massimo F Martelli; Cristina Mecucci
e6a2 BCR/ABL1 fusion with cryptic der(9)t(9;22) deletions in a patient with chronic myeloid leukemia.
Haematologica 2005;90(8):1139-41.
2005: Michele Malagola; giovanni martinelli; Michela Rondoni; Stefania Paolini; Stavrula Gaitani; Mario Arpinati; Pier Paolo Piccaluga; Marilina Amabile; Constanza Basi; Emanuela Ottaviani; Anna Candoni; Enrico Gottardi; Daniela Cilloni; Monica Bocchia; Giuseppe Saglio; Francesco Lauria; Renato Fanin; Giuseppe Visani; Maria Carla Marrè; Michela Maderna; Francesca Rancati; Vincenza Vinaccia; Domenico Russo; Michele Baccarani
Imatinib mesylate in the treatment of c-kit-positive acute myeloid leukemia: is this the real target?
Blood 2005;105(2):904; author reply 905.
2004: Daniela Cilloni; Francesca Messa; Sonia Carturan; Francesca Arruga; Ilaria Defilippi; Emanuela Messa; Enrico Gottardi; Giuseppe Saglio
Myelodysplastic syndromes.
Annals of the New York Academy of Sciences 2004;1028():400-8.
2004: Daniela Cilloni; Francesca Messa; Enrico Gottardi; Milena Fava; Francesca Arruga; Ilaria Defilippi; Sonia Carturan; Emanuela Messa; Alessandro Morotti; Emilia Giugliano; Giovanna Rege-Cambrin; Daniele Alberti; Michele Baccarani; Giuseppe Saglio
Sensitivity to imatinib therapy may be predicted by testing Wilms tumor gene expression and colony growth after a short in vitro incubation.
Cancer 2004;101(5):979-88.
2004: Daniela Cilloni; Sonia Carturan; Enrico Gottardi; Francesca Messa; Milena Fava; Ilaria Defilippi; Francesca Arruga; Giuseppe Saglio
Usefulness of the quantitative assessment of PRV-1 gene expression for the diagnosis of polycythemia vera and essential thrombocythemia patients.
Blood 2004;103(6):2428; author reply 2429.
2004: Gianantonio Rosti; giovanni martinelli; Simona Bassi; Marilina Amabile; Elena Trabacchi; Barbara Giannini; Daniela Cilloni; Barbara Izzo; Antonio de Vivo; Nicoletta Testoni; Giovanna Rege Cambrin; Francesca Bonifazi; Simona Soverini; Simona Luatti; Enrico Gottardi; Daniele Alberti; Fabrizio Pane; Francesco Salvatore; Giuseppe Saglio; Michele Baccarani
Molecular response to imatinib in late chronic-phase chronic myeloid leukemia.
Blood 2004;103(6):2284-90.
2003: Daniela Cilloni; Sonia Carturan; Enrico Gottardi; Francesca Messa; Emanuela Messa; Milena Fava; Daniela Diverio; Angelo Guerrasio; Francesco Lo Coco; Giuseppe Saglio
Down-modulation of the C/EBPalpha transcription factor in core binding factor acute myeloid leukemias.
Blood 2003;102(7):2705-6.
2003: Daniela Cilloni; Enrico Gottardi; Milena Fava; Francesca Messa; Sonia Carturan; Alessandro Busca; Angelo Guerrasio; Giuseppe Saglio
Usefulness of quantitative assessment of the WT1 gene transcript as a marker for minimal residual disease detection.
Blood 2003;102(2):773-4; author reply 774.
2003: Daniela Cilloni; Enrico Gottardi; Francesca Messa; Milena Fava; Patrizia Scaravaglio; Marilena Bertini; Mauro Girotto; Carlo Marinone; Dario Ferrero; Andrea Gallamini; Alessandro Levis; Giuseppe Saglio
Significant correlation between the degree of WT1 expression and the International Prognostic Scoring System Score in patients with myelodysplastic syndromes.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(10):1988-95.
2002: Daniela Cilloni; Enrico Gottardi; D De Micheli; Anna Serra; Gisella Volpe; Francesca Messa; Giovanna Rege-Cambrin; Angelo Guerrasio; Mariadomenica Divona; Francesco Lo Coco; Giuseppe Saglio
Quantitative assessment of WT1 expression by real time quantitative PCR may be a useful tool for monitoring minimal residual disease in acute leukemia patients.
Leukemia 2002;16(10):2115-21.
2002: Angelo Guerrasio; Chiara Pilatrino; D De Micheli; Daniela Cilloni; Anna Serra; Enrico Gottardi; A Parziale; Filippo Marmont; Daniela Diverio; Mariadomenica Divona; Francesco Lo Coco; Giuseppe Saglio
Assessment of minimal residual disease (MRD) in CBFbeta/MYH11-positive acute myeloid leukemias by qualitative and quantitative RT-PCR amplification of fusion transcripts.
Leukemia 2002;16(6):1176-81.
2002: Massimo Pini; Enrico Gottardi; Patrizia Scaravaglio; Emilia Giugliano; Roberta Libener; Anna Baraldi; Alberto Muzio; Elisa Cornaglia; Giuseppe Saglio; Alessandro Levis
A fourth case of BCR-FGFR1 positive CML-like disease with t(8;22) translocation showing an extensive deletion on the derivative chromosome 8p.
The hematology journal : the official journal of the European Haematology Association / EHA 2002;3(6):315-6.
2001: Daniele Mattei; G Saglio; Enrico Gottardi; Andrea Gallamini; Nicola Mordini; A Bacigalupo
Persisting molecular remission ten years after donor lymphocyte infusion for hematologic relapse in chronic myeloid leukemia.
Haematologica 2001;86(5):545-6.
2000: J Roman; A Parziale; Enrico Gottardi; D De Micheli; Daniela Cilloni; Mario Tiribelli; Maria Gracia Gonzalez; M del Carmen Rodriguez; Antonio Torres; Giuseppe Saglio
Novel type of BCR-ABL transcript in a chronic myelogenous leukaemia patient relapsed after bone marrow transplantation.
British journal of haematology 2000;111(2):644-6.
2000: Mario Tiribelli; Anna Tonso; D Ferrro; A Parzilae; G R Cambrin; Patrizia Scaravaglio; Daniela Cilloni; Enrico Gottardi; Giuseppe Saglio
Lack of SH3 domain does not imply a more severe clinical course in Ph+ chronic myeloid leukemia patients.
Blood 2000;95(12):4019-20.
1997: Antonella Roetto; M Cicilano; Enrico Gottardi; Angela Totaro; Massimo Carella; Paolo Gasparini; Clara Camaschella
A frequent polymorphism in the 5' region of the BCMA gene.
Molecular and cellular probes 1997;11(4):311-2.
1997: C Lanza; Gisella Volpe; Giuseppe Basso; Enrico Gottardi; F Perfetto; V Cilli; M Spinelli; Emanuela Ricotti; Angelo Guerrasio; Enrico Madon; Giuseppe Saglio
The common TEL/AML1 rearrangement does not represent a frequent event in acute lymphoblastic leukaemia occuring in children with Down syndrome.
Leukemia 1997;11(6):820-1.
1997: C Lanza; Gisella Volpe; Giuseppe Basso; Enrico Gottardi; Elena Barisone; M Spinelli; Emanuela Ricotti; V Cilli; F Perfetto; Enrico Madon; Giuseppe Saglio
Outcome and lineage involvement in t(12;21) childhood acute lymphoblastic leukaemia.
British journal of haematology 1997;97(2):460-2.
1997: Angelo Guerrasio; Anna Serra; Enrico Gottardi; Daniela Cilloni; F Vischia; Guido Parvis; V Cilli; Giuseppe Saglio
Molecular events in chronic myeloid leukemia progression.
Leukemia 1997;11 Suppl 3():519-21.
1996: Emanuele Papini; Enrico Gottardi; B Satin; Marina de Bernard; P Massari; J Telford; Rino Rappuoli; S B Sato; Cesare Montecucco
The vacuolar ATPase proton pump is present on intracellular vacuoles induced by Helicobacter pylori.
Journal of medical microbiology 1996;45(2):84-9.
1996: C Lanza; Enrico Gottardi; Gianluca Gaidano; C Vivenza; A Parziale; F Perfetto; M Fornaci; Elena Barisone; Enrico Madon; Giuseppe Basso; Giuseppe Saglio
Persistence of E2A/PBX1 transcripts in t(1;19) childhood acute lymphoblastic leukemia: correlation with chemotherapy intensity and clinical outcome.
Leukemia research 1996;20(5):441-3.
1996: Giuseppe Saglio; Fabrizio Pane; Enrico Gottardi; Ferdinando Frigeri; M R Buonaiuto; Angelo Guerrasio; D de Micheli; A Parziale; M N Fornaci; giovanni martinelli; Francesco Salvatore
Consistent amounts of acute leukemia-associated P190BCR/ABL transcripts are expressed by chronic myelogenous leukemia patients at diagnosis.
Blood 1996;87(3):1075-80.
1995: A Serra; Enrico Gottardi; F Della Ragione; Giuseppe Saglio; A Iolascon
Involvement of the cyclin-dependent kinase-4 inhibitor (CDKN2) gene in the pathogenesis of lymphoid blast crisis of chronic myelogenous leukaemia.
British journal of haematology 1995;91(3):625-9.
1995: Marina de Bernard; Emanuele Papini; V de Filippis; Enrico Gottardi; J Telford; Roberto Manetti; A Fontana; Rino Rappuoli; Cesare Montecucco
Low pH activates the vacuolating toxin of Helicobacter pylori, which becomes acid and pepsin resistant.
The Journal of biological chemistry 1995;270(41):23937-40.
1995: Clara Camaschella; U Mazza; Antonella Roetto; Enrico Gottardi; A Parziale; M Travi; S Fattore; D Bacchiega; Gemino Fiorelli; Maria Domenica Cappellini
Genetic interactions in thalassemia intermedia: analysis of beta-mutations, alpha-genotype, gamma-promoters, and beta-LCR hypersensitive sites 2 and 4 in Italian patients.
American journal of hematology 1995;48(2):82-7.
1994: Paolo Fortina; T Parrella; M Sartore; Enrico Gottardi; V Gabutti; K Delgrosso; ES Mansfield; Eric F Rappaport; E Schwartz; C Camaschella
Interaction of rare illegitimate recombination event and a poly A addition site mutation resulting in a severe form of alpha thalassemia.
Blood 1994;83(11):3356-62.
1994: G Esposito; M Grosso; Enrico Gottardi; Paola Izzo; C Camaschella; Francesco Salvatore
A unique origin for Sicilian (delta beta) (0)-thalassemia in 33 unrelated families and its rapid diagnostic characterization by PCR analysis.
Human genetics 1994;93(6):691-3.
1994: Giuseppe Saglio; Angelo Guerrasio; Enrico Gottardi; A Parziale; giovanni martinelli; Alfonso Zaccaria; F Frassoni
Significance of detection of BCR/ABL transcript after allogeneic and autologous transplant.
Bone marrow transplantation 1994;14 Suppl 3():S62-7.
1993: Paolo Gasparini; L Borgato; Alberto Piperno; Domenico Girelli; O Olivieri; Enrico Gottardi; Antonella Roetto; Irma Dianzani; Silvia Fargion; G Schinaia
Linkage analysis of 6p21 polymorphic markers and the hereditary hemochromatosis: localization of the gene centromeric to HLA-F.
Human molecular genetics 1993;2(5):571-6.
1992: Giuseppe Ricco; F Scaroina; M C Amprimo; Enrico Gottardi; A Parziale; Alda Alfarano; Clara Camaschella
Molecular characterization and functional studies on Hb Kempsey, beta 99 (G-1) Asp----Asn, a high-oxygen affinity variant.
Haematologica 1992;77(3):215-20.
1992: Enrico Gottardi; Monique Losekoot; Riccardo Fodde; Giuseppe Saglio; Clara Camaschella; L F Bernini
Rapid identification by denaturing gradient gel electrophoresis of mutations in the gamma-globin gene promoters in non-deletion type HPFH.
British journal of haematology 1992;80(4):533-8.
1991: Paolo Fortina; Irma Dianzani; A Serra; Enrico Gottardi; Giuseppe Saglio; L Farinasso; Antonio Piga; V Gabutti; Clara Camaschella
A newly-characterized alpha-thalassaemia-1 deletion removes the entire alpha-like globin gene cluster in an Italian family.
British journal of haematology 1991;78(4):529-34.
1991: Irma Dianzani; S M Forrest; C Camaschella; Enrico Gottardi; R G Cotton
Heterozygotes and homozygotes: discrimination by chemical cleavage of mismatch.
American journal of human genetics 1991;48(2):423-4.
1990: Alda Alfarano; Enrico Gottardi; A Serra; Antonio Piga; M Mandrino; U Mazza; Clara Camaschella
Screening of beta-thalassemia mutations by PCR and ASO analysis in an Italian population of mixed geographic origin.
Haematologica 1990;75(6):506-9.
1990: Clara Camaschella; A Serra; Alda Alfarano; Enrico Gottardi; D Revello; Maria Tiziana Bertero; L Oggiano; M Longinotti; Giuseppe Saglio
Deletion and non deletion hereditary persistence of fetal hemoglobin in Italy.
Haematologica 1990;75 Suppl 5():26-30.
1990: Clara Camaschella; Alda Alfarano; Enrico Gottardi; M Travi; P Primignani; Federico Caligaris-Cappio; Giuseppe Saglio
Prenatal diagnosis of fetal hemoglobin Lepore-Boston disease on maternal peripheral blood.
Blood 1990;75(11):2102-6.
1990: Clara Camaschella; Alda Alfarano; Enrico Gottardi; A Serra; D Revello; Giuseppe Saglio
The homozygous state for the -87 C----G beta + thalassaemia.
British journal of haematology 1990;75(1):132-3.
1990: Clara Camaschella; A Serra; Enrico Gottardi; Alda Alfarano; D Revello; U Mazza; Giuseppe Saglio
A new hereditary persistence of fetal hemoglobin deletion has the breakpoint within the 3' beta-globin gene enhancer.
Blood 1990;75(4):1000-5.
1990: Enrico Gottardi; Alda Alfarano; A Serra; G Sciarratta; Maria Tiziana Bertero; Giuseppe Saglio; Clara Camaschella
Molecular diagnosis of A gamma hereditary persistence of fetal hemoglobin using polymerase chain reaction and oligonucleotide analysis.
Haematologica 1990;75(1):17-20.
1989: Clara Camaschella; L Oggiano; Maurizio Sampietro; Enrico Gottardi; Alda Alfarano; P Pistidda; F Dore; Roberto Taramelli; Sergio Ottolenghi; M Longinotti
The homozygous state of G to A--117A gamma hereditary persistence of fetal hemoglobin.
Blood 1989;73(7):1999-2002.
1989: Clara Camaschella; A Serra; Maria Tiziana Bertero; Enrico Gottardi; Alda Alfarano; D Revello; M Travi; M Seia; Laura Cremonesi; M Ferrari
Molecular characterization of Italian chromosomes carrying the Lepore Boston gene.
Acta haematologica 1989;81(3):136-9.
1989: Clara Camaschella; A Serra; Enrico Gottardi; Alda Alfarano; D Revello; Maria Tiziana Bertero; Giuseppe Saglio
A new deletion in the beta globin gene cluster associated with high fetal hemoglobin production.
Progress in clinical and biological research 1989;316B():123-32.
1986: C Camaschella; A Serra; Maria Tiziana Bertero; M Trento; M Dall'Acqua; Enrico Gottardi; Paola Izzo; C Brancati; U Mazza; M Teno
Molecular characterization and hematological phenotype of Sicilian delta beta-thalassemia .
Haematologica 1986;71(4):287-92.