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Michael Gottesman

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
207
Pastan, Ira
31
Ambudkar, Suresh
20
germann, ursula
18
Cardarelli, Carol
18
Kimchi-Sarfaty, Chava
18
Liang, Xing-Jie
14
Shen, Ding-Wu
13
Licht, Thomas
12
Hrycyna, CA
12
Szakács, Gergely
11
Schoenlein, Patricia
10
Ramachandra, M
9
Oppenheim, Ariella
9
Aszalos, Adorjan
8
Dey, S

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Publications

TOP 3
Chen Kevin G; Valencia Julio C; Gillet Jean-Pierre; Hearing Vincent J; Gottesman Michael M
Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma.
Türk Dóra; Hall Matthew D; Chu Benjamin F; Ludwig Joseph A; Fales Henry M; Gottesman Michael M; Szakács Gergely
Identification of compounds selectively killing multidrug-resistant cancer cells.
Hall Matthew D; Handley Misty D; Gottesman Michael M
Is resistance useless? Multidrug resistance and collateral sensitivity.

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All Publications

2009: Chen Kevin G; Valencia Julio C; Gillet Jean-Pierre; Hearing Vincent J; Gottesman Michael M
Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma.
Pigment cell & melanoma research 2009;22(6):740-9.
2009: Türk Dóra; Hall Matthew D; Chu Benjamin F; Ludwig Joseph A; Fales Henry M; Gottesman Michael M; Szakács Gergely
Identification of compounds selectively killing multidrug-resistant cancer cells.
Cancer research 2009;69(21):8293-301.
2009: Hall Matthew D; Handley Misty D; Gottesman Michael M
Is resistance useless? Multidrug resistance and collateral sensitivity.
Trends in pharmacological sciences 2009;30(10):546-56.
2009: Kannan P; John C; Zoghbi S S; Halldin C; Gottesman M M; Innis R B; Hall M D
Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications.
Clinical pharmacology and therapeutics 2009;86(4):368-77.
2009: Chen Kevin G; Leapman Richard D; Zhang Guofeng; Lai Barry; Valencia Julio C; Cardarelli Carol O; Vieira Wilfred D; Hearing Vincent J; Gottesman Michael M
Influence of melanosome dynamics on melanoma drug sensitivity.
Journal of the National Cancer Institute 2009;101(18):1259-71.
2009: Orina Josiah N; Calcagno Anna Maria; Wu Chung-Pu; Varma Sudhir; Shih Joanna; Lin Min; Eichler Gabriel; Weinstein John N; Pommier Yves; Ambudkar Suresh V; Gottesman Michael M; Gillet Jean-Pierre
Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database.
Molecular cancer therapeutics 2009;8(7):2057-66.
2009: Wang Paul C; Blumenthal Robert P; Zhao Yuliang; Schneider Julie A; Miller Nancy; Grodzinski Piotr; Gottesman Michael M; Tinkle Sally; Wang Kuan; Wang Chen; Liang Xing-Jie
Building scientific progress without borders: nanobiology and nanomedicine in China and the U.S.
Cancer research 2009;69(13):5294-5.
2009: Brimacombe Kyle R; Hall Matthew D; Auld Douglas S; Inglese James; Austin Christopher P; Gottesman Michael M; Fung King-Leung
A dual-fluorescence high-throughput cell line system for probing multidrug resistance.
Assay and drug development technologies 2009;7(3):233-49.
2009: Gottesman Michael M; Ambudkar Suresh V; Xia Di
Structure of a multidrug transporter.
Nature biotechnology 2009;27(6):546-7.
2009: Hall Matthew D; Salam Noeris K; Hellawell Jennifer L; Fales Henry M; Kensler Caroline B; Ludwig Joseph A; Szakács Gergely; Hibbs David E; Gottesman Michael M
Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells.
Journal of medicinal chemistry 2009;52(10):3191-204.
2009: Fung King Leung; Gottesman Michael M
A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function.
Biochimica et biophysica acta 2009;1794(5):860-71.
2009: Hunt Ryan; Sauna Zuben E; Ambudkar Suresh V; Gottesman Michael M; Kimchi-Sarfaty Chava
Silent (synonymous) SNPs: should we care about them?
Methods in molecular biology (Clifton, N.J.) 2009;578():23-39.
2009: Gillet Jean-Pierre; Macadangdang Benjamin; Fathke Robert L; Gottesman Michael M; Kimchi-Sarfaty Chava
The development of gene therapy: from monogenic recessive disorders to complex diseases such as cancer.
Methods in molecular biology (Clifton, N.J.) 2009;542():5-54.
2008: Tsai Chung-Jung; Sauna Zuben E; Kimchi-Sarfaty Chava; Ambudkar Suresh V; Gottesman Michael M; Nussinov Ruth
Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima.
Journal of molecular biology 2008;383(2):281-91.
2008: Liang Xing-Jie; Yin Jun-Jie; Taylor Barbara; Winkovitch Stephen M; Garfield Susan H; Shen Ding-Wu; Gottesman Michael M; Aszalos Adorjan
Disruption of microfilaments by cytochalasin B decreases accumulation of cisplatin in human epidermal carcinoma and liver carcinoma cell lines.
Cancer chemotherapy and pharmacology 2008;62(6):977-84.
2008: Okabe Mitsunori; Szakács Gergely; Reimers Mark A; Suzuki Toshihiro; Hall Matthew D; Abe Takaaki; Weinstein John N; Gottesman Michael M
Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters.
Molecular cancer therapeutics 2008;7(9):3081-91.
2008: Liang Xing-Jie; Finkel Toren; Shen Ding-Wu; Yin Jun-Jie; Aszalos Adorjan; Gottesman Michael M
SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism.
Molecular cancer research : MCR 2008;6(9):1499-506.
2008: Elbaz Benayahu; Alperovitch Ariella; Gottesman Michael M; Kimchi-Sarfaty Chava; Rahamimoff Hannah
Modulation of Na+-Ca2+ exchanger expression by immunosuppressive drugs is isoform-specific.
Molecular pharmacology 2008;73(4):1254-63.
2008: Hall Matthew D; Okabe Mitsunori; Shen Ding-Wu; Liang Xing-Jie; Gottesman Michael M
The role of cellular accumulation in determining sensitivity to platinum-based chemotherapy.
Annual review of pharmacology and toxicology 2008;48():495-535.
2007: Wu Chung-Pu; Shukla Suneet; Calcagno Anna Maria; Hall Matthew D; Gottesman Michael M; Ambudkar Suresh V
Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance linked ABCG2 transporter.
Molecular cancer therapeutics 2007;6(12 Pt 1):3287-96.
2007: Sauna Zuben E; Kimchi-Sarfaty Chava; Ambudkar Suresh V; Gottesman Michael M
Silent polymorphisms speak: how they affect pharmacogenomics and the treatment of cancer.
Cancer research 2007;67(20):9609-12.
2007: Paterson Jill K; Shukla Suneet; Black Chelsea M; Tachiwada Tokushi; Garfield Susan; Wincovitch Stephen; Ernst David N; Agadir Anissa; Li Xuelin; Ambudkar Suresh V; Szakacs Gergely; Akiyama Shin-Ichi; Gottesman Michael M
Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane.
Biochemistry 2007;46(33):9443-52.
2007: Paterson Jill K; Gottesman Michael M
P-Glycoprotein is not present in mitochondrial membranes.
Experimental cell research 2007;313(14):3100-5.
2007: Sauna Zuben E; Kimchi-Sarfaty Chava; Ambudkar Suresh V; Gottesman Michael M
The sounds of silence: synonymous mutations affect function.
Pharmacogenomics 2007;8(6):527-32.
2007: Rahamimoff H; Elbaz B; Alperovich A; Kimchi-Sarfaty C; Gottesman M M; Lichtenstein Y; Eskin-Shwartz M; Kasir J
Cyclosporin A-dependent downregulation of the Na+/Ca2+ exchanger expression.
Annals of the New York Academy of Sciences 2007;1099():204-14.
2007: Kimchi-Sarfaty Chava; Marple Andrew H; Shinar Shiri; Kimchi Avraham M; Scavo David; Roma M Isabella; Kim In-Wha; Jones Adam; Arora Mili; Gribar John; Gurwitz David; Gottesman Michael M
Ethnicity-related polymorphisms and haplotypes in the human ABCB1 gene.
Pharmacogenomics 2007;8(1):29-39.
2007: Kimchi-Sarfaty Chava; Oh Jung Mi; Kim In-Wha; Sauna Zuben E; Calcagno Anna Maria; Ambudkar Suresh V; Gottesman Michael M
A "silent" polymorphism in the MDR1 gene changes substrate specificity.
Science (New York, N.Y.) 2007;315(5811):525-8.
2006: Kimchi-Sarfaty C; Vieira W D; Dodds D; Sherman A; Kreitman R J; Shinar S; Gottesman M M
SV40 Pseudovirion gene delivery of a toxin to treat human adenocarcinomas in mice.
Cancer gene therapy 2006;13(7):648-57.
2006: Nussenblatt Robert B; Chan Chi-Chao; Wilson Wyndham H; Hochman Jacob; Gottesman Michael;
International Central Nervous System and Ocular Lymphoma Workshop: recommendations for the future.
Ocular immunology and inflammation 2006;14(3):139-44.
2006: Chen Kevin G; Valencia Julio C; Lai Barry; Zhang Guofeng; Paterson Jill K; Rouzaud François; Berens Werner; Wincovitch Stephen M; Garfield Susan H; Leapman Richard D; Hearing Vincent J; Gottesman Michael M
Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(26):9903-7.
2006: Ludwig Joseph A; Szakács Gergely; Martin Scott E; Chu Benjamin F; Cardarelli Carol; Sauna Zuben E; Caplen Natasha J; Fales Henry M; Ambudkar Suresh V; Weinstein John N; Gottesman Michael M
Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer.
Cancer research 2006;66(9):4808-15.
2006: Shen Ding-Wu; Liang Xing-Jie; Suzuki Toshihiro; Gottesman Michael M
Identification by functional cloning from a retroviral cDNA library of cDNAs for ribosomal protein L36 and the 10-kDa heat shock protein that confer cisplatin resistance.
Molecular pharmacology 2006;69(4):1383-8.
2006: Szakács Gergely; Paterson Jill K; Ludwig Joseph A; Booth-Genthe Catherine; Gottesman Michael M
Targeting multidrug resistance in cancer.
Nature reviews. Drug discovery 2006;5(3):219-34.
2006: Gottesman Michael M; Ludwig Joseph; Xia Di; Szakács Gergely
Defeating drug resistance in cancer.
Discovery medicine 2006;6(31):18-23.
2006: Liang Xing-Jie; Mukherjee Sushmita; Shen Ding-Wu; Maxfield Frederick R; Gottesman Michael M
Endocytic recycling compartments altered in cisplatin-resistant cancer cells.
Cancer research 2006;66(4):2346-53.
2006: Gottesman Michael M; Ling Victor
The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research.
FEBS letters 2006;580(4):998-1009.
2006: Calcagno Anna Maria; Ludwig Joseph A; Fostel Jennifer M; Gottesman Michael M; Ambudkar Suresh V
Comparison of drug transporter levels in normal colon, colon cancer, and Caco-2 cells: impact on drug disposition and discovery.
Molecular pharmaceutics 2006;3(1):87-93.
2005: Liang Xing-Jie; Taylor Barbara; Cardarelli Carol; Yin Jun-Jie; Annereau Jean-Philippe; Garfield Susan; Wincovitch Stephen; Szakács Gergely; Gottesman Michael M; Aszalos Adorjan
Different roles for K+ channels in cisplatin-resistant cell lines argue against a critical role for these channels in cisplatin resistance.
Anticancer research 2005;25(6B):4113-22.
2005: Kimchi-Sarfaty Chava; Brittain Scott; Garfield Susan; Caplen Natasha J; Tang Qingquan; Gottesman Michael M
Efficient delivery of RNA interference effectors via in vitro-packaged SV40 pseudovirions.
Human gene therapy 2005;16(9):1110-5.
2005: Bar-Sinai Allan; Bassa Nir; Fischette Maria; Gottesman Michael M; Love Dona C; Hanover John A; Hochman Jacob
Mouse mammary tumor virus Env-derived peptide associates with nucleolar targets in lymphoma, mammary carcinoma, and human breast cancer.
Cancer research 2005;65(16):7223-30.
2005: Ambudkar Suresh V; Sauna Zuben E; Gottesman Michael M; Szakacs Gergely
A novel way to spread drug resistance in tumor cells: functional intercellular transfer of P-glycoprotein (ABCB1).
Trends in pharmacological sciences 2005;26(8):385-7.
2005: Tarasova Nadya I; Seth Rishi; Tarasov Sergey G; Kosakowska-Cholody Teresa; Hrycyna Christine A; Gottesman Michael M; Michejda Christopher J
Transmembrane inhibitors of P-glycoprotein, an ABC transporter.
Journal of medicinal chemistry 2005;48(11):3768-75.
2005: Chen Kevin G; Szakács Gergely; Annereau Jean-Philippe; Rouzaud Francois; Liang Xing-Jie; Valencia Julio C; Nagineni Chandrasekharam N; Hooks John J; Hearing Vincent J; Gottesman Michael M
Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2005;18(2):102-12.
2005: Liang Xing-Jie; Shen Ding-Wu; Chen Kevin G; Wincovitch Stephen M; Garfield Susan H; Gottesman Michael M
Trafficking and localization of platinum complexes in cisplatin-resistant cell lines monitored by fluorescence-labeled platinum.
Journal of cellular physiology 2005;202(3):635-41.
2005: Chen Kevin G; Gottesman Michael M
Useful tool to generate unidirectional deletion vectors by utilizing the star activity of BamHI in an NcoI-BamHI-XhoI cassette.
BioTechniques 2005;38(2):198, 200, 202, 204.
2004: Szakács Gergely; Gottesman Michael M
Comparing solid tumors with cell lines: implications for identifying drug resistance genes in cancer.
Molecular interventions 2004;4(6):323-5.
2004: Annereau Jean-Philippe; Szakács Gergely; Tucker Charles J; Arciello Angela; Cardarelli Carol; Collins Jennifer; Grissom Sherry; Zeeberg Barry R; Reinhold William; Weinstein John N; Pommier Yves; Paules Richard S; Gottesman Michael M
Analysis of ATP-binding cassette transporter expression in drug-selected cell lines by a microarray dedicated to multidrug resistance.
Molecular pharmacology 2004;66(6):1397-405.
2004: Kimchi-Sarfaty Chava; Gottesman Michael M
SV40 pseudovirions as highly efficient vectors for gene transfer and their potential application in cancer therapy.
Current pharmaceutical biotechnology 2004;5(5):451-8.
2004: Liang Xing-Jie; Shen Ding-Wu; Gottesman Michael M
A pleiotropic defect reducing drug accumulation in cisplatin-resistant cells.
Journal of inorganic biochemistry 2004;98(10):1599-606.
2004: Shen Ding-Wu; Liang Xing-Jie; Gawinowicz Mary Ann; Gottesman Michael M
Identification of cytoskeletal [14C]carboplatin-binding proteins reveals reduced expression and disorganization of actin and filamin in cisplatin-resistant cell lines.
Molecular pharmacology 2004;66(4):789-93.
2004: Kimchi-Sarfaty Chava; Alexander Nathan S; Brittain Scott; Ali Saadia; Gottesman Michael M
Transduction of multiple cell types using improved conditions for gene delivery and expression of SV40 pseudovirions packaged in vitro.
BioTechniques 2004;37(2):270-5.
2004: Szakács Gergely; Annereau Jean-Philippe; Lababidi Samir; Shankavaram Uma; Arciello Angela; Bussey Kimberly J; Reinhold William; Guo Yanping; Kruh Gary D; Reimers Mark; Weinstein John N; Gottesman Michael M
Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells.
Cancer cell 2004;6(2):129-37.
2004: Shen D-W; Su A; Liang X-J; Pai-Panandiker A; Gottesman M M
Reduced expression of small GTPases and hypermethylation of the folate binding protein gene in cisplatin-resistant cells.
British journal of cancer 2004;91(2):270-6.
2004: Gouazé Valerie; Yu Jing Y; Bleicher Richard J; Han Tie-Yan; Liu Yong-Yu; Wang Hongtao; Gottesman Michael M; Bitterman Arie; Giuliano Armando E; Cabot Myles C
Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy.
Molecular cancer therapeutics 2004;3(5):633-9.
2004: Liang Xing-Jie; Shen Ding-Wu; Gottesman Michael M
Down-regulation and altered localization of gamma-catenin in cisplatin-resistant adenocarcinoma cells.
Molecular pharmacology 2004;65(5):1217-24.
2004: Szakács Gergely; Chen G Kevin; Gottesman Michael M
The molecular mysteries underlying P-glycoprotein-mediated multidrug resistance.
Cancer biology & therapy 2004;3(4):382-4.
2004: Gottesman Michael
Michael Gottesman: purely academic.
Molecular interventions 2004;4(1):10-5.
2004: Liang Xing-Jie; Yin Jun-Jie; Zhou Jien-Wei; Wang Paul C; Taylor Barbara; Cardarelli Carol; Kozar Michael; Forte Raynard; Aszalos Adorjan; Gottesman Michael M
Changes in biophysical parameters of plasma membranes influence cisplatin resistance of sensitive and resistant epidermal carcinoma cells.
Experimental cell research 2004;293(2):283-91.
2004: Pétriz Jordi; Gottesman Michael M; Aran Josep M
An MDR-EGFP gene fusion allows for direct cellular localization, function and stability assessment of P-glycoprotein.
Current drug delivery 2004;1(1):43-56.
2003: Ambudkar Suresh V; Kimchi-Sarfaty Chava; Sauna Zuben E; Gottesman Michael M
P-glycoprotein: from genomics to mechanism.
Oncogene 2003;22(47):7468-85.
2003: Liang Xing-Jie; Shen Ding-Wu; Garfield Susan; Gottesman Michael M
Mislocalization of membrane proteins associated with multidrug resistance in cisplatin-resistant cancer cell lines.
Cancer research 2003;63(18):5909-16.
2003: Gottesman Michael M
Cancer gene therapy: an awkward adolescence.
Cancer gene therapy 2003;10(7):501-8.
2003: Ying Yu-Lan Mary; Shen Ding-Wu; Liang Xing-Jie; Gottesman Michael M
Codominance of cisplatin resistance in somatic cell hybrids.
Journal of cellular physiology 2003;196(1):63-9.
2003: Alemán Claudina; Annereau Jean-Philippe; Liang Xing-Jie; Cardarelli Carol O; Taylor Barbara; Yin Jun Jie; Aszalos Adorjan; Gottesman Michael M
P-glycoprotein, expressed in multidrug resistant cells, is not responsible for alterations in membrane fluidity or membrane potential.
Cancer research 2003;63(12):3084-91.
2003: Lelong-Rebel Isabelle H; Rebel Gérard; Cardarelli Carol O; Pastan Ira; Gottesman Michael M
Modulation by the ATP/GTP ratio of the phosphorylation level of P-glycoprotein and of various plasma membrane proteins of KB-V1 multidrug resistant cells.
Anticancer research 2003;23(3B):2363-75.
2003: Sugimoto Yoshikazu; Tsukahara Satomi; Sato Shigeo; Suzuki Mutsumi; Nunoi Hiroyuki; Malech Harry L; Gottesman Michael M; Tsuruo Takashi
Drug-selected co-expression of P-glycoprotein and gp91 in vivo from an MDR1-bicistronic retrovirus vector Ha-MDR-IRES-gp91.
The journal of gene medicine 2003;5(5):366-76.
2003: Chauhan S S; Liang X J; Su A W; Pai-Panandiker A; Shen D W; Hanover J A; Gottesman M M
Reduced endocytosis and altered lysosome function in cisplatin-resistant cell lines.
British journal of cancer 2003;88(8):1327-34.
2003: Stein Wilfred D; Robey Robert; Cardarelli Carol; Gottesman Michael M; Bates Susan E
Low and high concentrations of the topo II inhibitor daunorubicin in NIH3T3 cells: reversible G2/M versus irreversible G1 and S arrest.
Cell cycle (Georgetown, Tex.) 2003;2(2):134-42.
2003: Golin John; Ambudkar Suresh V; Gottesman Michael M; Habib Asif Dominic; Sczepanski John; Ziccardi William; May Leopold
Studies with novel Pdr5p substrates demonstrate a strong size dependence for xenobiotic efflux.
The Journal of biological chemistry 2003;278(8):5963-9.
2003: Kimchi-Sarfaty Chava; Arora Mili; Sandalon Ziv; Oppenheim Ariella; Gottesman Michael M
High cloning capacity of in vitro packaged SV40 vectors with no SV40 virus sequences.
Human gene therapy 2003;14(2):167-77.
2003: Lee Jae K; Bussey Kimberly J; Gwadry Fuad G; Reinhold William; Riddick Gregory; Pelletier Sandra L; Nishizuka Satoshi; Szakacs Gergely; Annereau Jean-Phillipe; Shankavaram Uma; Lababidi Samir; Smith Lawrence H; Gottesman Michael M; Weinstein John N
Comparing cDNA and oligonucleotide array data: concordance of gene expression across platforms for the NCI-60 cancer cells.
Genome biology 2003;4(12):R82.
2002: Pfutzner W; Terunuma A; Tock C L; Snead E K; Kolodka T M; Gottesman M M; Taichman L; Vogel J C
Topical colchicine selection of keratinocytes transduced with the multidrug resistance gene (MDR1) can sustain and enhance transgene expression in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):13096-101.
2002: Kimchi-Sarfaty Chava; Gribar John J; Gottesman Michael M
Functional characterization of coding polymorphisms in the human MDR1 gene using a vaccinia virus expression system.
Molecular pharmacology 2002;62(1):1-6.
2002: Licht Thomas; Haskins Mark; Henthorn Paula; Kleiman Sandra E; Bodine David M; Whitwam Todd; Puck Jennifer M; Gottesman Michael M; Melniczek John R
Drug selection with paclitaxel restores expression of linked IL-2 receptor gamma -chain and multidrug resistance (MDR1) transgenes in canine bone marrow.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):3123-8.
2002: Gottesman Michael M; Fojo Tito; Bates Susan E
Multidrug resistance in cancer: role of ATP-dependent transporters.
Nature reviews. Cancer 2002;2(1):48-58.
2002: Kimchi-Sarfaty Chava; Ben-Nun-Shaul Orly; Rund Deborah; Oppenheim Ariella; Gottesman Michael M
In vitro-packaged SV40 pseudovirions as highly efficient vectors for gene transfer.
Human gene therapy 2002;13(2):299-310.
2002: Gottesman Michael M
Mechanisms of cancer drug resistance.
Annual review of medicine 2002;53():615-27.
2001: Gottesman M M; Ambudkar S V
Overview: ABC transporters and human disease.
Journal of bioenergetics and biomembranes 2001;33(6):453-8.
2001: Lee C G; Vieira W D; Pastan I; Gottesman M M
An episomally maintained MDR1 gene for gene therapy.
Human gene therapy 2001;12(8):945-53.
2000: Sedelnikova O A; Panyutin I G; Luu A N; Reed M W; Licht T; Gottesman M M; Neumann R D
Targeting the human mdr1 gene by 125I-labeled triplex-forming oligonucleotides.
Antisense & nucleic acid drug development 2000;10(6):443-52.
2000: Booth C L; Pulaski L; Gottesman M M; Pastan I
Analysis of the properties of the N-terminal nucleotide-binding domain of human P-glycoprotein.
Biochemistry 2000;39(18):5518-26.
2000: Shen D W; Goldenberg S; Pastan I; Gottesman M M
Decreased accumulation of [14C]carboplatin in human cisplatin-resistant cells results from reduced energy-dependent uptake.
Journal of cellular physiology 2000;183(1):108-16.
2000: Hafkemeyer P; Licht T; Pastan I; Gottesman M M
Chemoprotection of hematopoietic cells by a mutant P-glycoprotein resistant to a potent chemosensitizer of multidrug-resistant cancers.
Human gene therapy 2000;11(4):555-65.
2000: Lee C G; Ramachandra M; Jeang K T; Martin M A; Pastan I; Gottesman M M
Effect of ABC transporters on HIV-1 infection: inhibition of virus production by the MDR1 transporter.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(3):516-22.
2000: Licht T; Goldenberg S K; Vieira W D; Gottesman M M; Pastan I
Drug selection of MDR1-transduced hematopoietic cells ex vivo increases transgene expression and chemoresistance in reconstituted bone marrow in mice.
Gene therapy 2000;7(4):348-58.
1999: Zhou Y; Gottesman M M; Pastan I
Domain exchangeability between the multidrug transporter (MDR1) and phosphatidylcholine flippase (MDR2).
Molecular pharmacology 1999;56(5):997-1004.
1999: Hrycyna C A; Ramachandra M; Germann U A; Cheng P W; Pastan I; Gottesman M M
Both ATP sites of human P-glycoprotein are essential but not symmetric.
Biochemistry 1999;38(42):13887-99.
1999: Licht T; Aran J M; Goldenberg S K; Vieira W D; Gottesman M M; Pastan I
Retroviral transfer of human MDR1 gene to hematopoietic cells: effects of drug selection and of transcript splicing on expression of encoded P-glycoprotein.
Human gene therapy 1999;10(13):2173-85.
1999: Cowan K H; Moscow J A; Huang H; Zujewski J A; O'Shaughnessy J; Sorrentino B; Hines K; Carter C; Schneider E; Cusack G; Noone M; Dunbar C; Steinberg S; Wilson W; Goldspiel B; Read E J; Leitman S F; McDonagh K; Chow C; Abati A; Chiang Y; Chang Y N; Gottesman M M; Pastan I; Nienhuis A
Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(7):1619-28.
1999: Moscow J A; Huang H; Carter C; Hines K; Zujewski J; Cusack G; Chow C; Venzon D; Sorrentino B; Chiang Y; Goldspiel B; Leitman S; Read E J; Abati A; Gottesman M M; Pastan I; Sellers S; Dunbar C; Cowan K H
Engraftment of MDR1 and NeoR gene-transduced hematopoietic cells after breast cancer chemotherapy.
Blood 1999;94(1):52-61.
1999: Zhou Y; Gottesman M M; Pastan I
The extracellular loop between TM5 and TM6 of P-glycoprotein is required for reactivity with monoclonal antibody UIC2.
Archives of biochemistry and biophysics 1999;367(1):74-80.
1999: Dey S; Hafkemeyer P; Pastan I; Gottesman M M
A single amino acid residue contributes to distinct mechanisms of inhibition of the human multidrug transporter by stereoisomers of the dopamine receptor antagonist flupentixol.
Biochemistry 1999;38(20):6630-9.
1999: Hafkemeyer P; Brinkmann U; Gottesman M M; Pastan I
Apoptosis induced by Pseudomonas exotoxin: a sensitive and rapid marker for gene delivery in vivo.
Human gene therapy 1999;10(6):923-34.
1999: Zhou Y; Gottesman M M; Pastan I
Studies of human MDR1-MDR2 chimeras demonstrate the functional exchangeability of a major transmembrane segment of the multidrug transporter and phosphatidylcholine flippase.
Molecular and cellular biology 1999;19(2):1450-9.
1999: Aran J M; Pastan I; Gottesman M M
Therapeutic strategies involving the multidrug resistance phenotype: the MDR1 gene as target, chemoprotectant, and selectable marker in gene therapy.
Advances in pharmacology (San Diego, Calif.) 1999;46():1-42.
1999: Ambudkar S V; Dey S; Hrycyna C A; Ramachandra M; Pastan I; Gottesman M M
Biochemical, cellular, and pharmacological aspects of the multidrug transporter.
Annual review of pharmacology and toxicology 1999;39():361-98.
1998: Hafkemeyer P; Dey S; Ambudkar S V; Hrycyna C A; Pastan I; Gottesman M M
Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein.
Biochemistry 1998;37(46):16400-9.
1998: Russ G; Ramachandra M; Hrycyna C A; Gottesman M M; Pastan I; Bennink J R; Yewdell J W
P-glycoprotein plays an insignificant role in the presentation of antigenic peptides to CD8+ T cells.
Cancer research 1998;58(20):4688-93.
1998: Shoshani T; Zhang S; Dey S; Pastan I; Gottesman M M
Analysis of random recombination between human MDR1 and mouse mdr1a cDNA in a pHaMDR-dihydrofolate reductase bicistronic expression system.
Molecular pharmacology 1998;54(4):623-30.
1998: Hrycyna C A; Airan L E; Germann U A; Ambudkar S V; Pastan I; Gottesman M M
Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport.
Biochemistry 1998;37(39):13660-73.
1998: Aran J M; Gottesman M M; Pastan I
Construction and characterization of bicistronic retroviral vectors encoding the multidrug transporter and beta-galactosidase or green fluorescent protein.
Cancer gene therapy 1998;5(4):195-206.
1998: Hrycyna C A; Ramachandra M; Ambudkar S V; Ko Y H; Pedersen P L; Pastan I; Gottesman M M
Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites.
The Journal of biological chemistry 1998;273(27):16631-4.
1998: Chauhan S S; Ray D; Kane S E; Willingham M C; Gottesman M M
Involvement of carboxy-terminal amino acids in secretion of human lysosomal protease cathepsin L.
Biochemistry 1998;37(23):8584-94.
1998: Kleiman S E; Pastan I; Puck J M; Gottesman M M
Characterization of an MDR1 retroviral bicistronic vector for correction of X-linked severe combined immunodeficiency.
Gene therapy 1998;5(5):671-6.
1998: Ramachandra M; Ambudkar S V; Chen D; Hrycyna C A; Dey S; Gottesman M M; Pastan I
Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state.
Biochemistry 1998;37(14):5010-9.
1998: Rund D; Dagan M; Dalyot-Herman N; Kimchi-Sarfaty C; Schoenlein P V; Gottesman M M; Oppenheim A
Efficient transduction of human hematopoietic cells with the human multidrug resistance gene 1 via SV40 pseudovirions.
Human gene therapy 1998;9(5):649-57.
1998: Lee C G; Gottesman M M; Cardarelli C O; Ramachandra M; Jeang K T; Ambudkar S V; Pastan I; Dey S
HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.
Biochemistry 1998;37(11):3594-601.
1998: Zhou Y; Aran J; Gottesman M M; Pastan I
Co-expression of human adenosine deaminase and multidrug resistance using a bicistronic retroviral vector.
Human gene therapy 1998;9(3):287-93.
1998: Shen D; Pastan I; Gottesman M M
Cross-resistance to methotrexate and metals in human cisplatin-resistant cell lines results from a pleiotropic defect in accumulation of these compounds associated with reduced plasma membrane binding proteins.
Cancer research 1998;58(2):268-75.
1998: Lee C G; Gottesman M M
HIV-1 protease inhibitors and the MDR1 multidrug transporter.
The Journal of clinical investigation 1998;101(2):287-8.
1998: Hrycyna C A; Gottesman M M
Multidrug ABC transporters from bacteria to man: an emerging hypothesis for the universality of molecular mechanism and function.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 1998;1(2):81-3.
1998: Lee C G; Pastan I; Gottesman M M
Retroviral transfer of human MDR1 gene into human T lymphocytes.
Methods in enzymology 1998;292():557-72.
1998: Licht T; Gottesman M M; Pastan I
Retroviral transfer of multidrug transporter to murine hematopoietic stem cells.
Methods in enzymology 1998;292():546-57.
1998: Sugimoto Y; Gottesman M M; Pastan I; Tsuruo T
Construction of MDR1 vectors for gene therapy.
Methods in enzymology 1998;292():523-37.
1998: Zhang S; Sugimoto Y; Shoshani T; Pastan I; Gottesman M M
pHaMDR-DHFR bicistronic expression system for mutational analysis of P-glycoprotein.
Methods in enzymology 1998;292():474-80.
1998: Hrycyna C A; Ramachandra M; Pastan I; Gottesman M M
Functional expression of human P-glycoprotein from plasmids using vaccinia virus-bacteriophage T7 RNA polymerase system.
Methods in enzymology 1998;292():456-73.
1998: Ramachandra M; Gottesman M M; Pastan I
Recombinant vaccinia virus vectors for functional expression of P-glycoprotein in mammalian cells.
Methods in enzymology 1998;292():441-55.
1998: Dey S; Ramachandra M; Pastan I; Gottesman M M; Ambudkar S V
Photoaffinity labeling of human P-glycoprotein: effect of modulator interaction and ATP hydrolysis on substrate binding.
Methods in enzymology 1998;292():318-28.
1998: Gottesman M M; Cardarelli C; Goldenberg S; Licht T; Pastan I
Selection and maintenance of multidrug-resistant cells.
Methods in enzymology 1998;292():248-58.
1997: Jhappan C; Morse H C; Fleischmann R D; Gottesman M M; Merlino G
DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus.
Nature genetics 1997;17(4):483-6.
1997: Lee C G; Jeang K T; Martin M A; Pastan I; Gottesman M M
Efficient long-term coexpression of a hammerhead ribozyme targeted to the U5 region of HIV-1 LTR by linkage to the multidrug-resistance gene.
Antisense & nucleic acid drug development 1997;7(5):511-22.
1997: Dey S; Ramachandra M; Pastan I; Gottesman M M; Ambudkar S V
Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(20):10594-9.
1997: Suzuki M; Sugimoto Y; Tsukahara S; Okochi E; Gottesman M M; Tsuruo T
Retroviral coexpression of two different types of drug resistance genes to protect normal cells from combination chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(6):947-54.
1997: Ohshima T; Murray G J; Swaim W D; Longenecker G; Quirk J M; Cardarelli C O; Sugimoto Y; Pastan I; Gottesman M M; Brady R O; Kulkarni A B
alpha-Galactosidase A deficient mice: a model of Fabry disease.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2540-4.
1997: Sugimoto Y; Sato S; Tsukahara S; Suzuki M; Okochi E; Gottesman M M; Pastan I; Tsuruo T
Coexpression of a multidrug resistance gene (MDR1) and herpes simplex virus thymidine kinase gene in a bicistronic retroviral vector Ha-MDR-IRES-TK allows selective killing of MDR1-transduced human tumors transplanted in nude mice.
Cancer gene therapy 1997;4(1):51-8.
1997: Licht T; Herrmann F; Gottesman M M; Pastan I
In vivo drug-selectable genes: a new concept in gene therapy.
Stem cells (Dayton, Ohio) 1997;15(2):104-11.
1996: Aran J M; Licht T; Gottesman M M; Pastan I
Complete restoration of glucocerebrosidase deficiency in Gaucher fibroblasts using a bicistronic MDR retrovirus and a new selection strategy.
Human gene therapy 1996;7(17):2165-75.
1996: Gottesman M M; Pastan I; Ambudkar S V
P-glycoprotein and multidrug resistance.
Current opinion in genetics & development 1996;6(5):610-7.
1996: Ramachandra M; Ambudkar S V; Gottesman M M; Pastan I; Hrycyna C A
Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.
Molecular biology of the cell 1996;7(10):1485-98.
1996: Baudard M; Flotte T R; Aran J M; Thierry A R; Pastan I; Pang M G; Kearns W G; Gottesman M M
Expression of the human multidrug resistance and glucocerebrosidase cDNAs from adeno-associated vectors: efficient promoter activity of AAV sequences and in vivo delivery via liposomes.
Human gene therapy 1996;7(11):1309-22.
1996: Johnson S W; Shen D; Pastan I; Gottesman M M; Hamilton T C
Cross-resistance, cisplatin accumulation, and platinum-DNA adduct formation and removal in cisplatin-sensitive and -resistant human hepatoma cell lines.
Experimental cell research 1996;226(1):133-9.
1996: Aksentijevich I; Cardarelli C O; Pastan I; Gottesman M M
Retroviral transfer of the human MDR1 gene confers resistance to bisantrene-specific hematotoxicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(6):973-80.
1996: Aksentijevich I; Pastan I; Lunardi-Iskandar Y; Gallo R C; Gottesman M M; Thierry A R
In vitro and in vivo liposome-mediated gene transfer leads to human MDR1 expression in mouse bone marrow progenitor cells.
Human gene therapy 1996;7(9):1111-22.
1996: Baudard M; Pastan I; Gottesman M M
Transfer of the MDR1 gene into haematopoietic cells.
European journal of cancer (Oxford, England : 1990) 1996;32A(6):1019-23.
1996: Weaver J L; McKinney L; Schoenlein P V; Goldenberg S; Gottesman M M; Aszalos A
MDR1/P-glycoprotein function. I. Effect of hypotonicity and inhibitors on rhodamine 123 exclusion.
The American journal of physiology 1996;270(5 Pt 1):C1447-52.
1996: Licht T; Pastan I; Gottesman M M; Herrmann F
The multidrug-resistance gene in gene therapy of cancer and hematopoietic disorders.
Annals of hematology 1996;72(4):184-93.
1996: Aran J M; Germann U A; Gottesman M M; Pastan I
Construction and characterization of a selectable multidrug resistance-glucocerebrosidase fusion gene.
Cytokines and molecular therapy 1996;2(1):47-57.
1996: Evans M K; Chin K V; Gottesman M M; Bohr V A
Gene-specific DNA repair and steady state transcription of the MDR1 gene in human tumor cell lines.
Oncogene 1996;12(3):651-8.
1996: Germann U A; Chambers T C; Ambudkar S V; Licht T; Cardarelli C O; Pastan I; Gottesman M M
Characterization of phosphorylation-defective mutants of human P-glycoprotein expressed in mammalian cells.
The Journal of biological chemistry 1996;271(3):1708-16.
1996: Müller M; Bakos E; Welker E; Váradi A; Germann U A; Gottesman M M; Morse B S; Roninson I B; Sarkadi B
Altered drug-stimulated ATPase activity in mutants of the human multidrug resistance protein.
The Journal of biological chemistry 1996;271(4):1877-83.
1996: Sokolic R A; Sekhsaria S; Sugimoto Y; Whiting-Theobald N; Linton G F; Li F; Gottesman M M; Malech H L
A bicistronic retrovirus vector containing a picornavirus internal ribosome entry site allows for correction of X-linked CGD by selection for MDR1 expression.
Blood 1996;87(1):42-50.
1996: Leonessa F; Green D; Licht T; Wright A; Wingate-Legette K; Lippman J; Gottesman M M; Clarke R
MDA435/LCC6 and MDA435/LCC6MDR1: ascites models of human breast cancer.
British journal of cancer 1996;73(2):154-61.
1995: Campain J A; Slovak M L; Schoenlein P V; Popescu N C; Gottesman M M; Pastan I
Acquisition of multiple copies of a mutant topoisomerase IIalpha allele by chromosome 17 aneuploidy is associated with etoposide resistance in human melanoma cell lines.
Somatic cell and molecular genetics 1995;21(6):451-71.
1995: Chambers T C; Germann U A; Gottesman M M; Pastan I; Kuo J F; Ambudkar S V
Bacterial expression of the linker region of human MDR1 P-glycoprotein and mutational analysis of phosphorylation sites.
Biochemistry 1995;34(43):14156-62.
1995: Aszalos A; Pine P S; Pandey R; Gottesman M M
Behavior of N-acylated daunorubicins in MDR1 gene transfected and parental cells.
Biochemical pharmacology 1995;50(6):889-92.
1995: Gottesman M M; Levine A S
The Devi case and more.
Science (New York, N.Y.) 1995;269(5227):1029-30.
1995: Licht T; Aksentijevich I; Gottesman M M; Pastan I
Efficient expression of functional human MDR1 gene in murine bone marrow after retroviral transduction of purified hematopoietic stem cells.
Blood 1995;86(1):111-21.
1995: Sugimoto Y; Aksentijevich I; Murray G J; Brady R O; Pastan I; Gottesman M M
Retroviral coexpression of a multidrug resistance gene (MDR1) and human alpha-galactosidase A for gene therapy of Fabry disease.
Human gene therapy 1995;6(7):905-15.
1995: Shen D W; Akiyama S; Schoenlein P; Pastan I; Gottesman M M
Characterisation of high-level cisplatin-resistant cell lines established from a human hepatoma cell line and human KB adenocarcinoma cells: cross-resistance and protein changes.
British journal of cancer 1995;71(4):676-83.
1995: Licht T; Gottesman M M; Pastan I
Transfer of the MDR1 (multidrug resistance) gene: protection of hematopoietic cells from cytotoxic chemotherapy, and selection of transduced cells in vivo.
Cytokines and molecular therapy 1995;1(1):11-20.
1995: Cardarelli C O; Aksentijevich I; Pastan I; Gottesman M M
Differential effects of P-glycoprotein inhibitors on NIH3T3 cells transfected with wild-type (G185) or mutant (V185) multidrug transporters.
Cancer research 1995;55(5):1086-91.
1995: Germann U A; Chambers T C; Ambudkar S V; Pastan I; Gottesman M M
Effects of phosphorylation of P-glycoprotein on multidrug resistance.
Journal of bioenergetics and biomembranes 1995;27(1):53-61.
1995: Evans G L; Ni B; Hrycyna C A; Chen D; Ambudkar S V; Pastan I; Germann U A; Gottesman M M
Heterologous expression systems for P-glycoprotein: E. coli, yeast, and baculovirus.
Journal of bioenergetics and biomembranes 1995;27(1):43-52.
1995: Gottesman M M; Hrycyna C A; Schoenlein P V; Germann U A; Pastan I
Genetic analysis of the multidrug transporter.
Annual review of genetics 1995;29():607-49.
1995: Galski H; Lazarovici P; Gottesman M M; Murakata C; Matsuda Y; Hochman J
KT-5720 reverses multidrug resistance in variant S49 mouse lymphoma cells transduced with the human MDR1 cDNA and in human multidrug-resistant carcinoma cells.
European journal of cancer (Oxford, England : 1990) 1995;31A(3):380-8.
1994: Wang N; Maurizi M R; Emmert-Buck L; Gottesman M M
Synthesis, processing, and localization of human Lon protease.
The Journal of biological chemistry 1994;269(46):29308-13.
1994: Licht T; Pastan I; Gottesman M; Herrmann F
P-glycoprotein-mediated multidrug resistance in normal and neoplastic hematopoietic cells.
Annals of hematology 1994;69(4):159-71.
1994: Gottesman M M
Report of a meeting: molecular basis of cancer therapy.
Journal of the National Cancer Institute 1994;86(17):1277-85.
1994: Gottesman M M; Collins F S
The role of the human genome project in disease prevention.
Preventive medicine 1994;23(5):591-4.
1994: Campain J A; Gottesman M M; Pastan I
A novel mutant topoisomerase II alpha present in VP-16-resistant human melanoma cell lines has a deletion of alanine 429.
Biochemistry 1994;33(37):11327-32.
1994: Morris D I; Greenberger L M; Bruggemann E P; Cardarelli C; Gottesman M M; Pastan I; Seamon K B
Localization of the forskolin labeling sites to both halves of P-glycoprotein: similarity of the sites labeled by forskolin and prazosin.
Molecular pharmacology 1994;46(2):329-37.
1994: Lelong I H; Cardarelli C O; Gottesman M M; Pastan I
GTP-stimulated phosphorylation of P-glycoprotein in transporting vesicles from KB-V1 multidrug resistant cells.
Biochemistry 1994;33(30):8921-9.
1994: Germann U A; Schoenlein P V; Zimonjic D B; Popescu N C; Pastan I; Gottesman M M
Putative "MDR enhancer" is located on human chromosome 20 and not linked to the MDR1 gene on chromosome 7.
Genes, chromosomes & cancer 1994;10(4):267-74.
1994: Sarkadi B; Müller M; Homolya L; Holló Z; Seprödi J; Germann U A; Gottesman M M; Price E M; Boucher R C
Interaction of bioactive hydrophobic peptides with the human multidrug transporter.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1994;8(10):766-70.
1994: Sugimoto Y; Aksentijevich I; Gottesman M M; Pastan I
Efficient expression of drug-selectable genes in retroviral vectors under control of an internal ribosome entry site.
Bio/technology (Nature Publishing Company) 1994;12(7):694-8.
1994: Gottesman M M; Germann U A; Aksentijevich I; Sugimoto Y; Cardarelli C O; Pastan I
Gene transfer of drug resistance genes. Implications for cancer therapy.
Annals of the New York Academy of Sciences 1994;716():126-38; discussion 138-43.
1994: Park J G; Lee S K; Hong I G; Kim H S; Lim K H; Choe K J; Kim W H; Kim Y I; Tsuruo T; Gottesman M M
MDR1 gene expression: its effect on drug resistance to doxorubicin in human hepatocellular carcinoma cell lines.
Journal of the National Cancer Institute 1994;86(9):700-5.
1994: Stein W D; Cardarelli C; Pastan I; Gottesman M M
Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates.
Molecular pharmacology 1994;45(4):763-72.
1994: Aran J M; Gottesman M M; Pastan I
Drug-selected coexpression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(8):3176-80.
1994: Yang J M; Goldenberg S; Gottesman M M; Hait W N
Characteristics of P388/VMDRC.04, a simple, sensitive model for studying P-glycoprotein antagonists.
Cancer research 1994;54(3):730-7.
1994: Siegsmund M J; Cardarelli C; Aksentijevich I; Sugimoto Y; Pastan I; Gottesman M M
Ketoconazole effectively reverses multidrug resistance in highly resistant KB cells.
The Journal of urology 1994;151(2):485-91.
1994: Gosse M E; Fleischmann R; Marshall M; Wang N; Garges S; Gottesman M M
Bacterial expression of Chinese hamster regulatory type-I and catalytic subunits of cyclic AMP-dependent protein kinase and mutational analysis of the type-I regulatory subunit.
The Biochemical journal 1994;297 ( Pt 1)():79-85.
1994: Nguyen K T; Liu B; Ueda K; Gottesman M M; Pastan I; Chin K V
Transactivation of the human multidrug resistance (MDR1) gene promoter by p53 mutants.
Oncology research 1994;6(2):71-7.
1994: Gottesman M M; Mickisch G H; Pastan I
In vivo models of P-glycoprotein-mediated multidrug resistance.
Cancer treatment and research 1994;73():107-28.
1994: Gottesman M M; Ambudkar S V; Ni B; Aran J M; Sugimoto Y; Cardarelli C O; Pastan I
Exploiting multidrug resistance to treat cancer.
Cold Spring Harbor symposia on quantitative biology 1994;59():677-83.
1993: Wang N; Gottesman S; Willingham M C; Gottesman M M; Maurizi M R
A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(23):11247-51.
1993: Altuvia S; Stein W D; Goldenberg S; Kane S E; Pastan I; Gottesman M M
Targeted disruption of the mouse mdr1b gene reveals that steroid hormones enhance mdr gene expression.
The Journal of biological chemistry 1993;268(36):27127-32.
1993: Homolya L; Holló Z; Germann U A; Pastan I; Gottesman M M; Sarkadi B
Fluorescent cellular indicators are extruded by the multidrug resistance protein.
The Journal of biological chemistry 1993;268(29):21493-6.
1993: Gosse M E; Padmanabhan A; Fleischmann R D; Gottesman M M
Expression of Chinese hamster cAMP-dependent protein kinase in Escherichia coli results in growth inhibition of bacterial cells: a model system for the rapid screening of mutant type I regulatory subunits.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(17):8159-63.
1993: Campain J A; Padmanabhan R; Hwang J; Gottesman M M; Pastan I
Characterization of an unusual mutant of human melanoma cells resistant to anticancer drugs that inhibit topoisomerase II.
Journal of cellular physiology 1993;155(2):414-25.
1993: Weaver J L; Szabo G; Pine P S; Gottesman M M; Goldenberg S; Aszalos A
The effect of ion channel blockers, immunosuppressive agents, and other drugs on the activity of the multi-drug transporter.
International journal of cancer. Journal international du cancer 1993;54(3):456-61.
1993: Germann U A; Pastan I; Gottesman M M
P-glycoproteins: mediators of multidrug resistance.
Seminars in cell biology 1993;4(1):63-76.
1993: Gottesman M M
How cancer cells evade chemotherapy: sixteenth Richard and Hinda Rosenthal Foundation Award Lecture.
Cancer research 1993;53(4):747-54.
1993: Chauhan S S; Popescu N C; Ray D; Fleischmann R; Gottesman M M; Troen B R
Cloning, genomic organization, and chromosomal localization of human cathepsin L.
The Journal of biological chemistry 1993;268(2):1039-45.
1993: Mickisch G H; Pai L H; Siegsmund M; Campain J; Gottesman M M; Pastan I
Pseudomonas exotoxin conjugated to monoclonal antibody MRK16 specifically kills multidrug resistant cells in cultured renal carcinomas and in MDR-transgenic mice.
The Journal of urology 1993;149(1):174-8.
1993: Chin K V; Pastan I; Gottesman M M
Function and regulation of the human multidrug resistance gene.
Advances in cancer research 1993;60():157-80.
1993: Gottesman M M; Pastan I
Biochemistry of multidrug resistance mediated by the multidrug transporter.
Annual review of biochemistry 1993;62():385-427.
1993: Kane S E; Gottesman M M
Use of multidrug resistance gene in mammalian expression vectors.
Methods in enzymology 1993;217():34-47.
1993: Padmanabhan R; Padmanabhan R; Howard T; Gottesman M M; Howard B H
Magnetic affinity cell sorting to isolate transiently transfected cells, multidrug-resistant cells, somatic cell hybrids, and virally infected cells.
Methods in enzymology 1993;218():637-51.
1992: Currier S J; Kane S E; Willingham M C; Cardarelli C O; Pastan I; Gottesman M M
Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR1-MDR2 transporters.
The Journal of biological chemistry 1992;267(35):25153-9.
1992: DelaFlor-Weiss E; Richardson C; Ward M; Himelstein A; Smith L; Podda S; Gottesman M; Pastan I; Bank A
Transfer and expression of the human multidrug resistance gene in mouse erythroleukemia cells.
Blood 1992;80(12):3106-11.
1992: Clarke R; Currier S; Kaplan O; Lovelace E; Boulay V; Gottesman M M; Dickson R B
Effect of P-glycoprotein expression on sensitivity to hormones in MCF-7 human breast cancer cells.
Journal of the National Cancer Institute 1992;84(19):1506-12.
1992: Podda S; Ward M; Himelstein A; Richardson C; de la Flor-Weiss E; Smith L; Gottesman M; Pastan I; Bank A
Transfer and expression of the human multiple drug resistance gene into live mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9676-80.
1992: Bruggemann E P; Currier S J; Gottesman M M; Pastan I
Characterization of the azidopine and vinblastine binding site of P-glycoprotein.
The Journal of biological chemistry 1992;267(29):21020-6.
1992: Chauhan S S; Gottesman M M
Construction of a new universal vector for insertional mutagenesis by homologous recombination.
Gene 1992;120(2):281-5.
1992: Ambudkar S V; Lelong I H; Zhang J; Cardarelli C O; Gottesman M M; Pastan I
Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(18):8472-6.
1992: Mickisch G H; Pai L H; Gottesman M M; Pastan I
Monoclonal antibody MRK16 reverses the multidrug resistance of multidrug-resistant transgenic mice.
Cancer research 1992;52(16):4427-32.
1992: Sorrentino B P; Brandt S J; Bodine D; Gottesman M; Pastan I; Cline A; Nienhuis A W
Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1.
Science (New York, N.Y.) 1992;257(5066):99-103.
1992: Chin K V; Chauhan S S; Abraham I; Sampson K E; Krolczyk A J; Wong M; Schimmer B; Pastan I; Gottesman M M
Reduced mRNA levels for the multidrug-resistance genes in cAMP-dependent protein kinase mutant cell lines.
Journal of cellular physiology 1992;152(1):87-94.
1992: Lelong I H; Padmanabhan R; Lovelace E; Pastan I; Gottesman M M
ATP and GTP as alternative energy sources for vinblastine transport by P-170 in KB-V1 plasma membrane vesicles.
FEBS letters 1992;304(2-3):256-60.
1992: Schoenlein P V; Shen D W; Barrett J T; Pastan I; Gottesman M M
Double minute chromosomes carrying the human multidrug resistance 1 and 2 genes are generated from the dimerization of submicroscopic circular DNAs in colchicine-selected KB carcinoma cells.
Molecular biology of the cell 1992;3(5):507-20.
1992: Mickisch G H; Rahman A; Pastan I; Gottesman M M
Increased effectiveness of liposome-encapsulated doxorubicin in multidrug-resistant-transgenic mice compared with free doxorubicin.
Journal of the National Cancer Institute 1992;84(10):804-5.
1992: Fleischmann R D; Jeng C; Gottesman M M
Ablation of stimulation of a cAMP-responsive promoter in CHO cell lines defective in their cAMP-dependent protein kinase system.
Somatic cell and molecular genetics 1992;18(2):103-11.
1992: Mickisch G H; Aksentijevich I; Schoenlein P V; Goldstein L J; Galski H; Stahle C; Sachs D H; Pastan I; Gottesman M M
Transplantation of bone marrow cells from transgenic mice expressing the human MDR1 gene results in long-term protection against the myelosuppressive effect of chemotherapy in mice.
Blood 1992;79(4):1087-93.
1992: Higgins C F; Gottesman M M
Is the multidrug transporter a flippase?
Trends in biochemical sciences 1992;17(1):18-21.
1992: Chin K V; Ueda K; Pastan I; Gottesman M M
Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.
Science (New York, N.Y.) 1992;255(5043):459-62.
1992: Goldstein L J; Pastan I; Gottesman M M
Multidrug resistance in human cancer.
Critical reviews in oncology/hematology 1992;12(3):243-53.
1992: Kessin R H; Fleischmann R D; Gottesman M M; Jastorff B; Van Lookeren Campagne M M
Use of the yeast low-Km cAMP-phosphodiesterase gene to control cyclic AMP levels in mammalian cells.
Advances in second messenger and phosphoprotein research 1992;25():13-27.
1991: Lelong I H; Guzikowski A P; Haugland R P; Pastan I; Gottesman M M; Willingham M C
Fluorescent verapamil derivative for monitoring activity of the multidrug transporter.
Molecular pharmacology 1991;40(4):490-4.
1991: Mickisch G H; Licht T; Merlino G T; Gottesman M M; Pastan I
Chemotherapy and chemosensitization of transgenic mice which express the human multidrug resistance gene in bone marrow: efficacy, potency, and toxicity.
Cancer research 1991;51(19):5417-24.
1991: Weaver J L; Pine P S; Aszalos A; Schoenlein P V; Currier S J; Padmanabhan R; Gottesman M M
Laser scanning and confocal microscopy of daunorubicin, doxorubicin, and rhodamine 123 in multidrug-resistant cells.
Experimental cell research 1991;196(2):323-9.
1991: Reddy P G; Graham G M; Datta S; Guarini L; Moulton T A; Jiang H P; Gottesman M M; Ferrone S; Fisher P B
Effect of recombinant fibroblast interferon and recombinant immune interferon on growth and the antigenic phenotype of multidrug-resistant human glioblastoma multiforme cells.
Journal of the National Cancer Institute 1991;83(18):1307-15.
1991: Pastan I; Willingham M C; Gottesman M
Molecular manipulations of the multidrug transporter: a new role for transgenic mice.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991;5(11):2523-8.
1991: Mickisch G H; Pastan I; Gottesman M M
Multidrug resistant transgenic mice as a novel pharmacologic tool.
BioEssays : news and reviews in molecular, cellular and developmental biology 1991;13(8):381-7.
1991: Mickisch G H; Merlino G T; Aiken P M; Gottesman M M; Pastan I
New potent verapamil derivatives that reverse multidrug resistance in human renal carcinoma cells and in transgenic mice expressing the human MDR1 gene.
The Journal of urology 1991;146(2):447-53.
1991: Howard P; Day K H; Kim K E; Richardson J; Thomas J; Abraham I; Fleischmann R D; Gottesman M M; Maurer R A
Decreased catalytic subunit mRNA levels and altered catalytic subunit mRNA structure in a cAMP-resistant Chinese hamster ovary cell line.
The Journal of biological chemistry 1991;266(16):10189-95.
1991: Padmanabhan R; Tsuruo T; Kane S E; Willingham M C; Howard B H; Gottesman M M; Pastan I
Magnetic-affinity cell sorting of human multidrug-resistant cells.
Journal of the National Cancer Institute 1991;83(8):565-9.
1991: Kaplan O; Jaroszewski J W; Clarke R; Fairchild C R; Schoenlein P; Goldenberg S; Gottesman M M; Cohen J S
The multidrug resistance phenotype: 31P nuclear magnetic resonance characterization and 2-deoxyglucose toxicity.
Cancer research 1991;51(6):1638-44.
1991: Chauhan S S; Goldstein L J; Gottesman M M
Expression of cathepsin L in human tumors.
Cancer research 1991;51(5):1478-81.
1991: Mendelson I; Gottesman M; Oppenheim A B
HU and integration host factor function as auxiliary proteins in cleavage of phage lambda cohesive ends by terminase.
Journal of bacteriology 1991;173(5):1670-6.
1991: Shen D W; Lu Y G; Chin K V; Pastan I; Gottesman M M
Human hepatocellular carcinoma cell lines exhibit multidrug resistance unrelated to MRD1 gene expression.
Journal of cell science 1991;98 ( Pt 3)():317-22.
1991: Cenciarelli C; Currier S J; Willingham M C; Thiebaut F; Germann U A; Rutherford A V; Gottesman M M; Barca S; Tombesi M; Morrone S; Santoni A; Mariani M; Ramoni C; Dupuis M L; Cianfriglia M
Characterization by somatic cell genetics of a monoclonal antibody to the MDR1 gene product (P-glycoprotein): determination of P-glycoprotein expression in multi-drug-resistant KB and CEM cell variants.
International journal of cancer. Journal international du cancer 1991;47(4):533-43.
1991: Bruggemann E P; Chaudhary V; Gottesman M M; Pastan I
Pseudomonas exotoxin fusion proteins are potent immunogens for raising antibodies against P-glycoprotein.
BioTechniques 1991;10(2):202-4, 206, 208-9.
1991: Troen B R; Chauhan S S; Ray D; Gottesman M M
Downstream sequences mediate induction of the mouse cathepsin L promoter by phorbol esters.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991;2(1):23-31.
1991: Horio M; Lovelace E; Pastan I; Gottesman M M
Agents which reverse multidrug-resistance are inhibitors of [3H]vinblastine transport by isolated vesicles.
Biochimica et biophysica acta 1991;1061(1):106-10.
1991: Mickisch G H; Merlino G T; Galski H; Gottesman M M; Pastan I
Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(2):547-51.
1991: Pastan I; Gottesman M M
Multidrug resistance.
Annual review of medicine 1991;42():277-86.
1991: Galski H; Merlino G T; Gottesman M M; Pastan I
Expression of a human multidrug-resistance cDNA (MDR1) under the control of a beta-actin promoter in transgenic mice.
Biotechnology (Reading, Mass.) 1991;16():103-24.
1991: Goldstein L J; Gottesman M M; Pastan I
Expression of the MDR1 gene in human cancers.
Cancer treatment and research 1991;57():101-19.
1991: Salminen A; Elson H F; Mickley L A; Fojo A T; Gottesman M M
Implantation of recombinant rat myocytes into adult skeletal muscle: a potential gene therapy.
Human gene therapy 1991;2(1):15-26.
1990: Hochman J; Park S S; Lazarovici P; Bergel M; Gottesman M M
Monoclonal antibodies to immunogenic lymphoma cell variants displaying impaired neoplastic properties: characterization and applications.
Journal of the National Cancer Institute 1990;82(23):1821-6.
1990: Schoenlein P V; Gottesman M M
Extrachromosomal DNA in human cancers.
Journal of the National Cancer Institute 1990;82(23):1798-800.
1990: Salminen A; Gottesman M M
Inhibitor studies indicate that active cathepsin L is probably essential to its own processing in cultured fibroblasts.
The Biochemical journal 1990;272(1):39-44.
1990: Sugawara I; Koji T; Ueda K; Pastan I; Gottesman M M; Nakane P K; Mori S
In situ localization of the human multidrug-resistance gene mRNA using thymine-thymine dimerized single-stranded cDNA.
Japanese journal of cancer research : Gann 1990;81(9):949-55.
1990: McLachlin J R; Eglitis M A; Ueda K; Kantoff P W; Pastan I H; Anderson W F; Gottesman M M
Expression of a human complementary DNA for the multidrug resistance gene in murine hematopoietic precursor cells with the use of retroviral gene transfer.
Journal of the National Cancer Institute 1990;82(15):1260-3.
1990: Horio M; Pastan I; Gottesman M M; Handler J S
Transepithelial transport of vinblastine by kidney-derived cell lines. Application of a new kinetic model to estimate in situ Km of the pump.
Biochimica et biophysica acta 1990;1027(2):116-22.
1990: Dickson R B; Gottesman M M
Understanding of the molecular basis of drug resistance in cancer reveals new targets for chemotherapy.
Trends in pharmacological sciences 1990;11(8):305-7.
1990: Kane S E; Pastan I; Gottesman M M
Genetic basis of multidrug resistance of tumor cells.
Journal of bioenergetics and biomembranes 1990;22(4):593-618.
1990: Chin K V; Chauhan S S; Pastan I; Gottesman M M
Regulation of mdr RNA levels in response to cytotoxic drugs in rodent cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1990;1(8):361-5.
1990: Abraham I; Chin K V; Gottesman M M; Mayo J K; Sampson K E
Transfection of a mutant regulatory subunit gene of cAMP-dependent protein kinase causes increased drug sensitivity and decreased expression of P-glycoprotein.
Experimental cell research 1990;189(1):133-41.
1990: Giladi H; Gottesman M; Oppenheim A B
Integration host factor stimulates the phage lambda pL promoter.
Journal of molecular biology 1990;213(1):109-21.
1990: Thiebaut F; Currier S J; Whitaker J; Haugland R P; Gottesman M M; Pastan I; Willingham M C
Activity of the multidrug transporter results in alkalinization of the cytosol: measurement of cytosolic pH by microinjection of a pH-sensitive dye.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1990;38(5):685-90.
1990: Kane S E; Gottesman M M
The role of cathepsin L in malignant transformation.
Seminars in cancer biology 1990;1(2):127-36.
1990: Van Lookeren Campagne M M; Wu E; Fleischmann R D; Gottesman M M; Chason K W; Kessin R H
Cyclic AMP responses are suppressed in mammalian cells expressing the yeast low Km cAMP-phosphodiesterase gene.
The Journal of biological chemistry 1990;265(10):5840-6.
1990: Germann U A; Willingham M C; Pastan I; Gottesman M M
Expression of the human multidrug transporter in insect cells by a recombinant baculovirus.
Biochemistry 1990;29(9):2295-303.
1990: Germann U A; Chin K V; Pastan I; Gottesman M M
Retroviral transfer of a chimeric multidrug resistance-adenosine deaminase gene.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1990;4(5):1501-7.
1990: Ford J M; Bruggemann E P; Pastan I; Gottesman M M; Hait W N
Cellular and biochemical characterization of thioxanthenes for reversal of multidrug resistance in human and murine cell lines.
Cancer research 1990;50(6):1748-56.
1990: Raviv Y; Pollard H B; Bruggemann E P; Pastan I; Gottesman M M
Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells.
The Journal of biological chemistry 1990;265(7):3975-80.
1990: Marino P A; Gottesman M M; Pastan I
Regulation of the multidrug resistance gene in regenerating rat liver.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1990;1(2):57-62.
1990: Goldstein L J; Fojo A T; Ueda K; Crist W; Green A; Brodeur G; Pastan I; Gottesman M M
Expression of the multidrug resistance, MDR1, gene in neuroblastomas.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1990;8(1):128-36.
1990: Tanaka S; Currier S J; Bruggemann E P; Ueda K; Germann U A; Pastan I; Gottesman M M
Use of recombinant P-glycoprotein fragments to produce antibodies to the multidrug transporter.
Biochemical and biophysical research communications 1990;166(1):180-6.
1990: Chen C J; Clark D; Ueda K; Pastan I; Gottesman M M; Roninson I B
Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins.
The Journal of biological chemistry 1990;265(1):506-14.
1990: Chin K V; Tanaka S; Darlington G; Pastan I; Gottesman M M
Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells.
The Journal of biological chemistry 1990;265(1):221-6.
1990: Sato H; Gottesman M M; Goldstein L J; Pastan I; Block A M; Sandberg A A; Preisler H D
Expression of the multidrug resistance gene in myeloid leukemias.
Leukemia research 1990;14(1):11-21.
1989: Smith S M; Gottesman M M
Activity and deletion analysis of recombinant human cathepsin L expressed in Escherichia coli.
The Journal of biological chemistry 1989;264(34):20487-95.
1989: Kane S E; Reinhard D H; Fordis C M; Pastan I; Gottesman M M
A new vector using the human multidrug resistance gene as a selectable marker enables overexpression of foreign genes in eukaryotic cells.
Gene 1989;84(2):439-46.
1989: Ueda K; Yamano Y; Kioka N; Kakehi Y; Yoshida O; Gottesman M M; Pastan I; Komano T
Detection of multidrug resistance (MDR1) gene RNA expression in human tumors by a sensitive ribonuclease protection assay.
Japanese journal of cancer research : Gann 1989;80(11):1127-32.
1989: Galski H; Sullivan M; Willingham M C; Chin K V; Gottesman M M; Pastan I; Merlino G T
Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia.
Molecular and cellular biology 1989;9(10):4357-63.
1989: Bourhis J; Goldstein L J; Riou G; Pastan I; Gottesman M M; Bénard J
Expression of a human multidrug resistance gene in ovarian carcinomas.
Cancer research 1989;49(18):5062-5.
1989: Kane S E; Gottesman M M
Multidrug resistance in the laboratory and clinic.
Cancer cells (Cold Spring Harbor, N.Y. : 1989) 1989;1(1):33-6.
1989: Horio M; Chin K V; Currier S J; Goldenberg S; Williams C; Pastan I; Gottesman M M; Handler J
Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia.
The Journal of biological chemistry 1989;264(25):14880-4.
1989: Smith S M; Kane S E; Gal S; Mason R W; Gottesman M M
Glycosylation of procathepsin L does not account for species molecular-mass differences and is not required for proteolytic activity.
The Biochemical journal 1989;262(3):931-8.
1989: Bruggemann E P; Germann U A; Gottesman M M; Pastan I
Two different regions of P-glycoprotein [corrected] are photoaffinity-labeled by azidopine.
The Journal of biological chemistry 1989;264(26):15483-8.
1989: Lai S L; Goldstein L J; Gottesman M M; Pastan I; Tsai C M; Johnson B E; Mulshine J L; Ihde D C; Kayser K; Gazdar A F
MDR1 gene expression in lung cancer.
Journal of the National Cancer Institute 1989;81(15):1144-50.
1989: Currier S J; Ueda K; Willingham M C; Pastan I; Gottesman M M
Deletion and insertion mutants of the multidrug transporter.
The Journal of biological chemistry 1989;264(24):14376-81.
1989: Kioka N; Tsubota J; Kakehi Y; Komano T; Gottesman M M; Pastan I; Ueda K
P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance.
Biochemical and biophysical research communications 1989;162(1):224-31.
1989: Konen P L; Currier S J; Rutherford A V; Gottesman M M; Pastan I; Willingham M C
The multidrug transporter: rapid modulation of efflux activity monitored in single cells by the morphologic effects of vinblastine and daunomycin.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1989;37(7):1141-5.
1989: Kanamaru H; Kakehi Y; Yoshida O; Nakanishi S; Pastan I; Gottesman M M
MDR1 RNA levels in human renal cell carcinomas: correlation with grade and prediction of reversal of doxorubicin resistance by quinidine in tumor explants.
Journal of the National Cancer Institute 1989;81(11):844-9.
1989: Germann U A; Gottesman M M; Pastan I
Expression of a multidrug resistance-adenosine deaminase fusion gene.
The Journal of biological chemistry 1989;264(13):7418-24.
1989: Gottesman M M; Pastan I
Clinical trials of agents that reverse multidrug-resistance.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1989;7(4):409-11.
1989: Banker D E; Pastan I; Gottesman M M; Herschman H R
An epidermal growth factor-ricin A chain (EGF-RTA)-resistant mutant and an epidermal growth factor-Pseudomonas endotoxin (EGF-PE)-resistant mutant have distinct phenotypes.
Journal of cellular physiology 1989;139(1):51-7.
1989: Thiebaut F; Tsuruo T; Hamada H; Gottesman M M; Pastan I; Willingham M C
Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1989;37(2):159-64.
1989: Pirker R; Goldstein L J; Ludwig H; Linkesch W; Lechner C; Gottesman M M; Pastan I
Expression of a multidrug resistance gene in blast crisis of chronic myelogenous leukemia.
Cancer communications 1989;1(2):141-4.
1988: Yoshimoto K; Iwahana H; Yokogoshi Y; Saito S; Shiraishi M; Sekiya T; Gottesman M M; Pastan I
A polymorphic HindIII site within the human multidrug resistance gene 1 (MDR1).
Nucleic acids research 1988;16(24):11850.
1988: Gottesman M M
Multidrug resistance during chemical carcinogenesis: a mechanism revealed?
Journal of the National Cancer Institute 1988;80(17):1352-3.
1988: Richert N D; Aldwin L; Nitecki D; Gottesman M M; Pastan I
Stability and covalent modification of P-glycoprotein in multidrug-resistant KB cells.
Biochemistry 1988;27(20):7607-13.
1988: Gottesman M M; Pastan I
The multidrug transporter, a double-edged sword.
The Journal of biological chemistry 1988;263(25):12163-6.
1988: Shen D W; Pastan I; Gottesman M M
In situ hybridization analysis of acquisition and loss of the human multidrug-resistance gene.
Cancer research 1988;48(15):4334-9.
1988: Kane S E; Troen B R; Gal S; Ueda K; Pastan I; Gottesman M M
Use of a cloned multidrug resistance gene for coamplification and overproduction of major excreted protein, a transformation-regulated secreted acid protease.
Molecular and cellular biology 1988;8(8):3316-21.
1988: Gal S; Gottesman M M
Isolation and sequence of a cDNA for human pro-(cathepsin L).
The Biochemical journal 1988;253(1):303-6.
1988: Amano F; Gottesman M M; Pastan I
Epidermal growth factor-dependent growth of human KB cells in a defined medium and altered growth factor requirements of KB mutants resistant to EGF-Pseudomonas exotoxin conjugates.
Journal of cellular physiology 1988;135(3):502-8.
1988: Amano F; Pastan I; Gottesman M M
Genetic characterization of human KB cell lines resistant to epidermal growth factor: Pseudomonas exotoxin conjugates.
Journal of cellular physiology 1988;135(3):527-32.
1988: Pastan I; Gottesman M M; Ueda K; Lovelace E; Rutherford A V; Willingham M C
A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(12):4486-90.
1988: McCoy K; Gal S; Schwartz R H; Gottesman M M
An acid protease secreted by transformed cells interferes with antigen processing.
The Journal of cell biology 1988;106(6):1879-84.
1988: Horio M; Gottesman M M; Pastan I
ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(10):3580-4.
1988: Chabner B A; Gottesman M M
Meeting highlights: William Guy Forbeck Foundation think tank on "multidrug resistance in cancer chemotherapy".
Journal of the National Cancer Institute 1988;80(6):391-4.
1988: Kakehi Y; Kanamaru H; Yoshida O; Ohkubo H; Nakanishi S; Gottesman M M; Pastan I
Measurement of multidrug-resistance messenger RNA in urogenital cancers; elevated expression in renal cell carcinoma is associated with intrinsic drug resistance.
The Journal of urology 1988;139(4):862-5.
1988: Gottesman M M; Pastan I
Resistance to multiple chemotherapeutic agents in human cancer cells.
Trends in pharmacological sciences 1988;9(2):54-8.
1988: Akiyama S; Cornwell M M; Kuwano M; Pastan I; Gottesman M M
Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog.
Molecular pharmacology 1988;33(2):144-7.
1988: Troen B R; Ascherman D; Atlas D; Gottesman M M
Cloning and expression of the gene for the major excreted protein of transformed mouse fibroblasts. A secreted lysosomal protease regulated by transformation.
The Journal of biological chemistry 1988;263(1):254-61.
1988: Pastan I H; Gottesman M M
Molecular biology of multidrug resistance in human cells.
Important advances in oncology 1988;():3-16.
1987: Fojo A T; Shen D W; Mickley L A; Pastan I; Gottesman M M
Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1987;5(12):1922-7.
1987: Mason R W; Gal S; Gottesman M M
The identification of the major excreted protein (MEP) from a transformed mouse fibroblast cell line as a catalytically active precursor form of cathepsin L.
The Biochemical journal 1987;248(2):449-54.
1987: Ueda K; Pastan I; Gottesman M M
Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene.
The Journal of biological chemistry 1987;262(36):17432-6.
1987: Willingham M C; Richert N D; Cornwell M M; Tsuruo T; Hamada H; Gottesman M M; Pastan I H
Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1987;35(12):1451-6.
1987: Hammer K; Jensen K F; Poulsen P; Oppenheim A B; Gottesman M
Isolation of Escherichia coli rpoB mutants resistant to killing by lambda cII protein and altered in pyrE gene attenuation.
Journal of bacteriology 1987;169(11):5289-97.
1987: Thiebaut F; Tsuruo T; Hamada H; Gottesman M M; Pastan I; Willingham M C
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7735-8.
1987: Hwang J; Richert N; Pastan I; Gottesman M M
Mutant KB cells with decreased EGF receptor expression: biochemical characterization.
Journal of cellular physiology 1987;133(1):127-34.
1987: Troen B R; Gal S; Gottesman M M
Sequence and expression of the cDNA for MEP (major excreted protein), a transformation-regulated secreted cathepsin.
The Biochemical journal 1987;246(3):731-5.
1987: Abraham I; Hunter R J; Sampson K E; Smith S; Gottesman M M; Mayo J K
Cyclic AMP-dependent protein kinase regulates sensitivity of cells to multiple drugs.
Molecular and cellular biology 1987;7(9):3098-106.
1987: Cornwell M M; Tsuruo T; Gottesman M M; Pastan I
ATP-binding properties of P glycoprotein from multidrug-resistant KB cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1987;1(1):51-4.
1987: FitzGerald D J; Willingham M C; Cardarelli C O; Hamada H; Tsuruo T; Gottesman M M; Pastan I
A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(12):4288-92.
1987: Lyall R M; Hwang J L; Cardarelli C; FitzGerald D; Akiyama S; Gottesman M M; Pastan I
Isolation of human KB cell lines resistant to epidermal growth factor-Pseudomonas exotoxin conjugates.
Cancer research 1987;47(11):2961-6.
1987: Thorgeirsson S S; Huber B E; Sorrell S; Fojo A; Pastan I; Gottesman M M
Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver.
Science (New York, N.Y.) 1987;236(4805):1120-2.
1987: Pastan I; Gottesman M
Multiple-drug resistance in human cancer.
The New England journal of medicine 1987;316(22):1388-93.
1987: Ueda K; Cardarelli C; Gottesman M M; Pastan I
Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(9):3004-8.
1987: Cornwell M M; Pastan I; Gottesman M M
Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.
The Journal of biological chemistry 1987;262(5):2166-70.
1987: Ueda K; Clark D P; Chen C J; Roninson I B; Gottesman M M; Pastan I
The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation.
The Journal of biological chemistry 1987;262(2):505-8.
1987: Fojo A T; Ueda K; Slamon D J; Poplack D G; Gottesman M M; Pastan I
Expression of a multidrug-resistance gene in human tumors and tissues.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(1):265-9.
1987: Gottesman M M
Strategies for isolation of mutant genes.
Methods in enzymology 1987;151():329-32.
1987: Gottesman M M
Chinese hamster ovary cells.
Methods in enzymology 1987;151():3-8.
1987: Gottesman M M
Drug-resistant mutants: selection and dominance analysis.
Methods in enzymology 1987;151():113-21.
1987: Fojo A; Cornwell M; Cardarelli C; Clark D P; Richert N; Shen D W; Ueda K; Willingham M; Gottesman M M; Pastan I
Molecular biology of drug resistance.
Breast cancer research and treatment 1987;9(1):5-16.
1986: Ueda K; Cornwell M M; Gottesman M M; Pastan I; Roninson I B; Ling V; Riordan J R
The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein.
Biochemical and biophysical research communications 1986;141(3):956-62.
1986: Shen D W; Fojo A; Roninson I B; Chin J E; Soffir R; Pastan I; Gottesman M M
Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene.
Molecular and cellular biology 1986;6(11):4039-45.
1986: Willingham M C; Cornwell M M; Cardarelli C O; Gottesman M M; Pastan I
Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.
Cancer research 1986;46(11):5941-6.
1986: Chen C J; Chin J E; Ueda K; Clark D P; Pastan I; Gottesman M M; Roninson I B
Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.
Cell 1986;47(3):381-9.
1986: Abraham I; Dion R L; Chi D M; Gottesman M M; Hamel E
2,4-Dichlorobenzyl thiocyanate, an antimitotic agent that alters microtubule morphology.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(18):6839-43.
1986: Aszalos A; Damjanovich S; Gottesman M M
Depolymerization of microtubules alters membrane potential and affects the motional freedom of membrane proteins.
Biochemistry 1986;25(19):5804-9.
1986: Gal S; Gottesman M M
The major excreted protein (MEP) of transformed mouse cells and cathepsin L have similar protease specificity.
Biochemical and biophysical research communications 1986;139(1):156-62.
1986: Fojo A; Lebo R; Shimizu N; Chin J E; Roninson I B; Merlino G T; Gottesman M M; Pastan I
Localization of multidrug resistance-associated DNA sequences to human chromosome 7.
Somatic cell and molecular genetics 1986;12(4):415-20.
1986: Cornwell M M; Gottesman M M; Pastan I H
Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells.
The Journal of biological chemistry 1986;261(17):7921-8.
1986: Shen D W; Cardarelli C; Hwang J; Cornwell M; Richert N; Ishii S; Pastan I; Gottesman M M
Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.
The Journal of biological chemistry 1986;261(17):7762-70.
1986: Roninson I B; Chin J E; Choi K G; Gros P; Housman D E; Fojo A; Shen D W; Gottesman M M; Pastan I
Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(12):4538-42.
1986: Cornwell M M; Safa A R; Felsted R L; Gottesman M M; Pastan I
Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(11):3847-50.
1986: Whitfield C; Abraham I; Ascherman D; Gottesman M M
Transfer and amplification of a mutant beta-tubulin gene results in colcemid dependence: use of the transformant to demonstrate regulation of beta-tubulin subunit levels by protein degradation.
Molecular and cellular biology 1986;6(5):1422-9.
1986: Shen D W; Fojo A; Chin J E; Roninson I B; Richert N; Pastan I; Gottesman M M
Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification.
Science (New York, N.Y.) 1986;232(4750):643-5.
1986: Gal S; Gottesman M M
The major excreted protein of transformed fibroblasts is an activable acid-protease.
The Journal of biological chemistry 1986;261(4):1760-5.
1986: Rabin M S; Doherty P J; Gottesman M M
The tumor promoter phorbol 12-myristate 13-acetate induces a program of altered gene expression similar to that induced by platelet-derived growth factor and transforming oncogenes.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(2):357-60.
1986: Mahajna J; Oppenheim A B; Rattray A; Gottesman M
Translation initiation of bacteriophage lambda gene cII requires integration host factor.
Journal of bacteriology 1986;165(1):167-74.
1986: Gottesman M M; Fleischmann R; Abraham I
Molecular genetic analysis of cAMP-dependent protein kinase.
Annals of the New York Academy of Sciences 1986;478():162-74.
1986: Gottesman M M; Fleischmann R D
The role of cAMP in regulating tumour cell growth.
Cancer surveys 1986;5(2):291-308.
1985: Fojo A T; Whang-Peng J; Gottesman M M; Pastan I
Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(22):7661-5.
1985: Abraham I; Brill S; Hyde J; Fleischmann R; Chapman M; Gottesman M M
DNA-mediated gene transfer of a mutant regulatory subunit of cAMP-dependent protein kinase.
The Journal of biological chemistry 1985;260(26):13934-40.
1985: Singh T J; Hochman J; Verna R; Chapman M; Abraham I; Pastan I H; Gottesman M M
Characterization of a cyclic AMP-resistant Chinese hamster ovary cell mutant containing both wild-type and mutant species of type I regulatory subunit of cyclic AMP-dependent protein kinase.
The Journal of biological chemistry 1985;260(26):13927-33.
1985: Frick K K; Doherty P J; Gottesman M M; Scher C D
Regulation of the transcript for a lysosomal protein: evidence for a gene program modified by platelet-derived growth factor.
Molecular and cellular biology 1985;5(10):2582-9.
1985: Kuriyama R; Borisy G G; Binder L I; Gottesman M M
Tubulin composition and microtubule nucleation of a griseofulvin-resistant Chinese hamster ovary cell mutant with abnormal spindles.
Experimental cell research 1985;160(2):527-39.
1985: Fojo A; Akiyama S; Gottesman M M; Pastan I
Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.
Cancer research 1985;45(7):3002-7.
1985: Aszalos A; Yang G C; Gottesman M M
Depolymerization of microtubules increases the motional freedom of molecular probes in cellular plasma membranes.
The Journal of cell biology 1985;100(5):1357-62.
1985: Richert N; Akiyama S; Shen D; Gottesman M M; Pastan I
Multiply drug-resistant human KB carcinoma cells have decreased amounts of a 75-kDa and a 72-kDa glycoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(8):2330-3.
1985: Doherty P J; Hua L; Liau G; Gal S; Graham D E; Sobel M; Gottesman M M
Malignant transformation and tumor promoter treatment increase levels of a transcript for a secreted glycoprotein.
Molecular and cellular biology 1985;5(3):466-73.
1985: Akiyama S; Fojo A; Hanover J A; Pastan I; Gottesman M M
Isolation and genetic characterization of human KB cell lines resistant to multiple drugs.
Somatic cell and molecular genetics 1985;11(2):117-26.
1985: Akiyama S; Seth P; Pirker R; FitzGerald D; Gottesman M M; Pastan I
Potentiation of cytotoxic activity of immunotoxins on cultured human cells.
Cancer research 1985;45(3):1005-7.
1985: Gal S; Willingham M C; Gottesman M M
Processing and lysosomal localization of a glycoprotein whose secretion is transformation stimulated.
The Journal of cell biology 1985;100(2):535-44.
1984: Gottesman M M; Roth C; Vlahakis G; Pastan I
Cholera toxin treatment stimulates tumorigenicity of Rous sarcoma virus-transformed cells.
Molecular and cellular biology 1984;4(12):2639-42.
1984: Hochman J; Levy E; Mador N; Gottesman M M; Shearer G M; Okon E
Cell adhesiveness is related to tumorigenicity in malignant lymphoid cells.
The Journal of cell biology 1984;99(4 Pt 1):1282-8.
1984: Akiyama S; Gottesman M M; Hanover J A; Fitzgerald D J; Willingham M C; Pastan I
Verapamil enhances the toxicity of conjugates of epidermal growth factor with Pseudomonas exotoxin and antitransferrin receptor with Pseudomonas exotoxin.
Journal of cellular physiology 1984;120(3):271-9.
1984: Rattray A; Altuvia S; Mahajna G; Oppenheim A B; Gottesman M
Control of bacteriophage lambda CII activity by bacteriophage and host functions.
Journal of bacteriology 1984;159(1):238-42.
1983: Abraham I; Marcus M; Cabral F; Gottesman M M
Mutations in alpha- and beta-tubulin affect spindle formation in Chinese hamster ovary cells.
The Journal of cell biology 1983;97(4):1055-61.
1983: Roth C W; Richert N D; Pastan I; Gottesman M M
Cyclic AMP treatment of Rous sarcoma virus-transformed Chinese hamster ovary cells increases phosphorylation of pp60src and increases pp60src kinase activity.
The Journal of biological chemistry 1983;258(17):10768-73.
1983: Banerjee D K; Baksi K; Gottesman M M
Genetic evidence that action of cAMP-dependent protein kinase is not an obligatory step for antiviral and antiproliferative effects of human interferon in Chinese hamster ovary cells.
Virology 1983;129(1):230-8.
1982: Lichti U; Gottesman M M
Genetic evidence that a phorbol ester tumor promoter stimulates ornithine decarboxylase activity by a pathway that is independent of cyclic AMP-dependent protein kinases in CHO cells.
Journal of cellular physiology 1982;113(3):433-9.
1982: Sahagian G G; Gottesman M M
The predominant secreted protein of transformed murine fibroblasts carries the lysosomal mannose 6-phosphate recognition marker.
The Journal of biological chemistry 1982;257(18):11145-50.
1982: Oppenheim A B; Gottesman S; Gottesman M
Regulation of bacteriophage lambda int gene expression.
Journal of molecular biology 1982;158(3):327-46.
1982: Cabral F; Abraham I; Gottesman M M
Revertants of a Chinese hamster ovary cell mutant with an altered beta-tubulin: evidence that the altered tubulin confers both colcemid resistance and temperature sensitivity on the cell.
Molecular and cellular biology 1982;2(6):720-9.
1982: Roth C W; Singh T; Pastan I; Gottesman M M
Rous sarcoma virus transformed cells are resistant to cyclic AMP.
Journal of cellular physiology 1982;111(1):42-8.
1982: Abraham I; Tyagi J S; Gottesman M M
Transfer of genes to Chinese hamster ovary cells by DNA-mediated transformation.
Somatic cell genetics 1982;8(1):23-39.
1982: Pastan I H; Willingham M; de Crombrugghe B; Gottesman M M
Aging and cancer: cyclic 3', 5'-adenosine monophosphate and altered gene activity.
National Cancer Institute monograph 1982;60():7-15.
1981: Cabral F; Abraham I; Gottesman M M
Isolation of a taxol-resistant Chinese hamster ovary cell mutant that has an alteration in alpha-tubulin.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(7):4388-91.
1981: Cabral F; Gottesman M M; Yuspa S H
Induction of specific protein synthesis by phorbol esters in mouse epidermal cell culture.
Cancer research 1981;41(6):2025-31.
1981: Steinert P M; Idler W W; Cabral F; Gottesman M M; Goldman R D
In vitro assembly of homopolymer and copolymer filaments from intermediate filament subunits of muscle and fibroblastic cells.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(6):3692-6.
1981: LeCam A; Gottesman M M; Pastan I
Glycogen synthase activity in Chinese hamster ovary cells. Studies with wild-type and mutant cells defective in cyclic AMP-dependent protein kinase.
Biochimica et biophysica acta 1981;675(1):94-100.
1981: Gottesman S; Gottesman M; Shaw J E; Pearson M L
Protein degradation in E. coli: the lon mutation and bacteriophage lambda N and cII protein stability.
Cell 1981;24(1):225-33.
1981: Gottesman M M; Cabral F
Purification and characterization of a transformation-dependent protein secreted by cultured murine fibroblasts.
Biochemistry 1981;20(6):1659-65.
1981: Cabral F; Gottesman M M; Zimmerman S B; Steinert P M
Intermediate filaments from Chinese hamster ovary cells contain a single protein. Comparison with more complex systems from baby hamster kidney and mouse epidermal cells.
The Journal of biological chemistry 1981;256(3):1428-31.
1981: LeCam A; Nicolas J C; Singh T J; Cabral F; Pastan I; Gottesman M M
Cyclic AMP-dependent phosphorylation in intact cells and in cell-free extracts from Chinese hamster ovary cells. Studies with wild type and cyclic AMP-resistant mutants.
The Journal of biological chemistry 1981;256(2):933-41.
1981: Singh T J; Roth C; Gottesman M M; Pastan I H
Characterization of cyclic AMP-resistant Chinese hamster ovary cell mutants lacking type I protein kinase.
The Journal of biological chemistry 1981;256(2):926-32.
1981: Gottesman M M; Yuspa S H
Tumor promoters induce the synthesis of a secreted glycoprotein in mouse skin and cultured primary mouse epidermal cells.
Carcinogenesis 1981;2(10):971-6.
1980: Gottesman M M
Genetic approaches to cyclic AMP effects in cultured mammalian cells.
Cell 1980;22(2 Pt 2):329-30.
1980: LeCam A; Gottesman M M; Pastan I
Mechanism of cyclic AMP effect on nutrient transport in Chinese hamster ovary cells. A genetic approach.
The Journal of biological chemistry 1980;255(17):8103-8.
1980: Milhaud P; Yamada K M; Gottesman M M
Sodium butyrate affects expression of fibronectin on CHO cells: specific increase in antibody-complement-mediated cytotoxicity.
Journal of cellular physiology 1980;104(2):163-70.
1980: Cabral F; Willingham M C; Gottesman M M
Ultrastructural localization to 10 nm filaments of an insoluble 58K protein in cultured fibroblasts.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1980;28(7):653-62.
1980: Milhaud P G; Davies P J; Pastan I; Gottesman M M
Regulation of transglutaminase activity in Chinese hamster ovary cells.
Biochimica et biophysica acta 1980;630(4):476-84.
1980: Cabral F; Sobel M E; Gottesman M M
CHO mutants resistant to colchicine, colcemid or griseofulvin have an altered beta-tubulin.
Cell 1980;20(1):29-36.
1980: Gottesman M M; Sobel M E
Tumor promoters and Kirsten sarcoma virus increase synthesis of a secreted glycoprotein by regulating levels of translatable mRNA.
Cell 1980;19(2):449-55.
1980: Gottesman M M; LeCam A; Bukowski M; Pastan I
Isolation of multiple classes of mutants of CHO cells resistant to cyclic AMP.
Somatic cell genetics 1980;6(1):45-61.
1979: Gottesman M M
Workshop on "mutation and gene transfer in somatic cells".
Somatic cell genetics 1979;5(5):665-71.
1979: Rabin M S; Gottesman M M
High frequency of mutation to tubercidin resistance in CHO cells.
Somatic cell genetics 1979;5(5):571-83.
1979: Evain D; Gottesman M; Pastan I; Anderson W B
A mutation affecting the catalytic subunit of cyclic AMP-dependent protein kinase in CHO cells.
The Journal of biological chemistry 1979;254(15):6931-7.
1979: Cabral F; Gottesman M M
Phosphorylation of the 10-nm filament protein from Chinese hamster ovary cells.
The Journal of biological chemistry 1979;254(14):6203-6.
1979: Simon L D; Gottesman M; Tomczak K; Gottesman S
Hyperdegradation of proteins in Escherichia coli rho mutants.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(4):1623-7.
1978: Cabral F; Gottesman M M
The determination of similarities in amino acid composition among proteins separated by two-dimensional gel electrophoresis.
Analytical biochemistry 1978;91(2):548-56.
1978: Gottesman M M
Transformation-dependent secretion of a low molecular weight protein by murine fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(6):2767-71.
1976: Gottesman M M
Isolation and characterization of a lambda specialized transducing phage for the Escherichia coli DNA ligase gene.
Virology 1976;72(1):33-44.
1976: Shulman M J; Mizuuchi K; Gottesman M M
New att mutants of phage lambda.
Virology 1976;72(1):13-22.
1975: Gottesman M M; Rosner J L
Acquisition of a determinant for chloramphenicol resistance by coliphage lambda.
Proceedings of the National Academy of Sciences of the United States of America 1975;72(12):5041-5.
1975: Nakanishi S; Adhya S; Gottesman M; Pastan I
Selective effects of MgCl2 and temperature on the initiation of transcription at lac, gal, and lambda promoters.
The Journal of biological chemistry 1975;250(20):8202-8.
1975: Gottesman S; Gottesman M
Excision of prophage lambda in a cell-free system.
Proceedings of the National Academy of Sciences of the United States of America 1975;72(6):2188-92.
1974: Gottesman M M; Gottesman M E; Gottesman S; Gellert M
Characterization of bacteriophage lambda reverse as an Escherichia coli phage carrying a unique set of host-derived recombination functions.
Journal of molecular biology 1974;88(2):471-87.
1974: Nakanishi S; Adhya S; Gottesman M; Pastan I
Effects of dimethylsulfoxide on the E. coli gal operon and on bacteriophage lambda in vivo.
Cell 1974;3(1):39-46.
1974: Nakanishi S; Adhya S; Gottesman M; Pastan I
Activation of transcription at specific promoters by glycerol.
The Journal of biological chemistry 1974;249(13):4050-6.
1973: Nakanishi S; Adhya S; Gottesman M; Pastan I
Studies on the mechanism of action of the gal repressor.
The Journal of biological chemistry 1973;248(17):5937-42.
1973: Gottesman M M; Hicks M L; Gellert M
Genetics and function of DNA ligase in Escherichia coli.
Journal of molecular biology 1973;77(4):531-47.
1973: De Crombrugghe B; Adhya S; Gottesman M; Pastan I
Effect of Rho on transcription of bacterial operons.
Nature: New biology 1973;241(113):260-4.
1971: Parks J S; Gottesman M; Shimada K; Weisberg R A; Perlman R L; Pastan I
Isolation of the gal repressor.
Proceedings of the National Academy of Sciences of the United States of America 1971;68(8):1891-5.
1971: De Crombrugghe B; Chen B; Anderson W; Nissley P; Gottesman M; Pastan I; Perlman R
Lac DNA, RNA polymerase and cyclic AMP receptor protein, cyclic AMP, lac repressor and inducer are the essential elements for controlled lac transcription.
Nature: New biology 1971;231(22):139-42.
1971: Parks J S; Gottesman M; Perlman R L; Pastan I
Regulation of galactokinase synthesis by cyclic adenosine 3',5'-monophosphate in cell-free extracts of Escherichia coli.
The Journal of biological chemistry 1971;246(8):2419-24.
1971: De Crombrugghe B; Chen B; Gottesman M; Pastan I; Varmus H E; Emmer M; Perlman R L
Regulation of lac mRNA synthesis in a soluble cell-free system.
Nature: New biology 1971;230(10):37-40.
1966: Gottesman M M; Beck W S
Transfer of hydrogen in the cobamide-dependent ribonucleotide reductase reaction.
Biochemical and biophysical research communications 1966;24(3):353-9.

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