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Otto Götze

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Martin Oppermann; Tamara Manuelian; Mihály Józsi; E Brandt; T. Sakari Jokiranta; Stefan Heinen; Seppo Meri; Christine Skerka; Otto Götze; Peter F Zipfel
The C-terminus of complement regulator Factor H mediates target recognition: evidence for a compact conformation of the native protein.
Thorsten Demberg; Ines Heine; Otto Götze; Wolfgang Altermann; Barbara Seliger; Gerald Schlaf
Recombinant generation of two fragments of the rat complement inhibitory factor H [FH(SCR1-7) and FH(SCR1-4)] and their structural and functional characterization in comparison to FH isolated from rat serum.
Gerald Schlaf; Frauke Nitzki; Ines Heine; Rüdiger Hardeland; Henrike L Schieferdecker; Otto Götze
C5a anaphylatoxin as a product of complement activation up-regulates the complement inhibitory factor H in rat Kupffer cells.

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2006: Martin Oppermann; Tamara Manuelian; Mihály Józsi; E Brandt; T. Sakari Jokiranta; Stefan Heinen; Seppo Meri; Christine Skerka; Otto Götze; Peter F Zipfel
The C-terminus of complement regulator Factor H mediates target recognition: evidence for a compact conformation of the native protein.
Clinical and experimental immunology 2006;144(2):342-52.
2006: Thorsten Demberg; Ines Heine; Otto Götze; Wolfgang Altermann; Barbara Seliger; Gerald Schlaf
Recombinant generation of two fragments of the rat complement inhibitory factor H [FH(SCR1-7) and FH(SCR1-4)] and their structural and functional characterization in comparison to FH isolated from rat serum.
Histology and histopathology 2006;21(1):93-102.
2004: Gerald Schlaf; Frauke Nitzki; Ines Heine; Rüdiger Hardeland; Henrike L Schieferdecker; Otto Götze
C5a anaphylatoxin as a product of complement activation up-regulates the complement inhibitory factor H in rat Kupffer cells.
European journal of immunology 2004;34(11):3257-66.
2004: Gerald Schlaf; M Schmitz; Ines Heine; Thorsten Demberg; Henrike L Schieferdecker; Otto Götze
Upregulation of fibronectin but not of entactin, collagen IV and smooth muscle actin by anaphylatoxin C5a in rat hepatic stellate cells.
Histology and histopathology 2004;19(4):1165-74.
2003: Sabine Pestel; Gerald Schlaf; Otto Götze; Kurt Jungermann; Henrike L Schieferdecker
Differences in the involvement of prostanoids from Kupffer cells in the mediation of anaphylatoxin C5a-, zymosan-, and lipopolysaccharide-dependent hepatic glucose output and flow reduction.
Laboratory investigation; a journal of technical methods and pathology 2003;83(12):1733-41.
2003: Gerald Schlaf; M Schmitz; E Rothermel; Kurt Jungermann; Henrike L Schieferdecker; Otto Götze
Expression and induction of anaphylatoxin C5a receptors in the rat liver.
Histology and histopathology 2003;18(1):299-308.
2002: Thorsten Demberg; Beatrix Pollok-Kopp; D Gerke; Otto Götze; Gerald Schlaf
Rat complement factor H: molecular cloning, sequencing and quantification with a newly established ELISA.
Scandinavian journal of immunology 2002;56(2):149-60.
2002: Sabine Pestel; Kurt Jungermann; Otto Götze; Henrike L Schieferdecker
Inhibition by prostaglandin E(2) of anaphylatoxin C5a- but not zymosan-induced prostanoid release from rat Kupffer cells.
Laboratory investigation; a journal of technical methods and pathology 2002;82(4):463-71.
2002: Milena Koleva; Gerald Schlaf; Regine Landmann; Otto Götze; Kurt Jungermann; Henrike L Schieferdecker
Induction of anaphylatoxin C5a receptors in rat hepatocytes by lipopolysaccharide in vivo: mediation by interleukin-6 from Kupffer cells.
Gastroenterology 2002;122(3):697-708.
2002: Gerald Schlaf; Nadine Beisel; Beatrix Pollok-Kopp; Henrike L Schieferdecker; Thorsten Demberg; Otto Götze
Constitutive expression and regulation of rat complement factor H in primary cultures of hepatocytes, Kupffer cells, and two hepatoma cell lines.
Laboratory investigation; a journal of technical methods and pathology 2002;82(2):183-92.
2001: Wolfgang Füreder; Gerit-Holger Schernthaner; Minoo Ghannadan; Alexander W Hauswirth; Wolfgang R Sperr; Hans Semper; Yasamin Majlesi; Jörg Zwirner; Otto Götze; Hans-Jörg Bühring; Klaus Lechner; Peter Valent
Quantitative, phenotypic, and functional evaluation of basophils in myelodysplastic syndromes.
European journal of clinical investigation 2001;31(10):894-901.
2001: C Mäck; Kurt Jungermann; Otto Götze; Henrike L Schieferdecker
Anaphylatoxin C5a actions in rat liver: synergistic enhancement by C5a of lipopolysaccharide-dependent alpha(2)-macroglobulin gene expression in hepatocytes via IL-6 release from Kupffer cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(7):3972-9.
2001: Gerald Schlaf; Thorsten Demberg; N Beisel; Henrike L Schieferdecker; Otto Götze
Expression and regulation of complement factors H and I in rat and human cells: some critical notes.
Molecular immunology 2001;38(2-3):231-9.
2001: Gerald Schlaf; Thorsten Demberg; Milena Koleva; Kurt Jungermann; Otto Götze
Complement factor I is upregulated in rat hepatocytes by interleukin-6 but not by interferon-gamma, interleukin-1beta, or tumor necrosis factor-alpha.
Biological chemistry 2001;382(7):1089-94.
2001: K Kirchhoff; O Weinmann; Jörg Zwirner; G Begemann; Otto Götze; Alexander Kapp; Thomas Werfel
Detection of anaphylatoxin receptors on CD83+ dendritic cells derived from human skin.
Immunology 2001;103(2):210-7.
2001: Henrike L Schieferdecker; Gerald Schlaf; Kurt Jungermann; Otto Götze
Functions of anaphylatoxin C5a in rat liver: direct and indirect actions on nonparenchymal and parenchymal cells.
International immunopharmacology 2001;1(3):469-81.
2000: Thomas Werfel; K Kirchhoff; Miriam Wittmann; G Begemann; Alexander Kapp; Fedor Heidenreich; Otto Götze; Jörg Zwirner
Activated human T lymphocytes express a functional C3a receptor.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6599-605.
2000: E Rothermel; Otto Götze; S Zahn; Gerald Schlaf
Analysis of the tissue distribution of the rat C5a receptor and inhibition of C5a-mediated effects through the use of two MoAbs.
Scandinavian journal of immunology 2000;52(4):401-10.
2000: Henrike L Schieferdecker; Gerald Schlaf; Milena Koleva; Otto Götze; Kurt Jungermann
Induction of functional anaphylatoxin C5a receptors on hepatocytes by in vivo treatment of rats with IL-6.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(10):5453-8.
2000: Afshin Fayyazi; O Scheel; Thomas Werfel; Stefan Schweyer; Martin Oppermann; Otto Götze; Heinz-Joachim Radzun; Jörg Zwirner
The C5a receptor is expressed in normal renal proximal tubular but not in normal pulmonary or hepatic epithelial cells.
Immunology 2000;99(1):38-45.
1999: Gerald Schlaf; E Rothermel; Martin Oppermann; Henrike L Schieferdecker; Kurt Jungermann; Otto Götze
Rat complement factor I: molecular cloning, sequencing and expression in tissues and isolated cells.
Immunology 1999;98(3):464-74.
1999: Gerald Schlaf; Henrike L Schieferdecker; E Rothermel; Kurt Jungermann; Otto Götze
Differential expression of the C5a receptor on the main cell types of rat liver as demonstrated with a novel monoclonal antibody and by C5a anaphylatoxin-induced Ca2+ release.
Laboratory investigation; a journal of technical methods and pathology 1999;79(10):1287-97.
1999: Jörg Zwirner; Afshin Fayyazi; Otto Götze
Expression of the anaphylatoxin C5a receptor in non-myeloid cells.
Molecular immunology 1999;36(13-14):877-84.
1999: Henrike L Schieferdecker; Sabine Pestel; Gerhard P Püschel; Otto Götze; Kurt Jungermann
Increase by anaphylatoxin C5a of glucose output in perfused rat liver via prostanoids derived from nonparenchymal cells: direct action of prostaglandins and indirect action of thromboxane A(2) on hepatocytes.
Hepatology (Baltimore, Md.) 1999;30(2):454-61.
1999: HC Wilken; S Rogge; Otto Götze; Thomas Werfel; Jörg Zwirner
Specific detection by flow cytometry of histidine-tagged ligands bound to their receptors using a tag-specific monoclonal antibody.
Journal of immunological methods 1999;226(1-2):139-45.
1999: Miriam Wittmann; Jörg Zwirner; V A Larsson; K Kirchhoff; G Begemann; Alexander Kapp; Otto Götze; Thomas Werfel
C5a suppresses the production of IL-12 by IFN-gamma-primed and lipopolysaccharide-challenged human monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(11):6763-9.
1999: Jörg Zwirner; Otto Götze; G Begemann; Alexander Kapp; K Kirchhoff; Thomas Werfel
Evaluation of C3a receptor expression on human leucocytes by the use of novel monoclonal antibodies.
Immunology 1999;97(1):166-72.
1999: HC Wilken; Otto Götze; Thomas Werfel; Jörg Zwirner
C3a(desArg) does not bind to and signal through the human C3a receptor.
Immunology letters 1999;67(2):141-5.
1999: Afshin Fayyazi; Raoul Sandau; L Q Duong; Otto Götze; Heinz-Joachim Radzun; Stefan Schweyer; Afsaneh Soruri; Jörg Zwirner
C5a receptor and interleukin-6 are expressed in tissue macrophages and stimulated keratinocytes but not in pulmonary and intestinal epithelial cells.
The American journal of pathology 1999;154(2):495-501.
1999: Holger Petering; Otto Götze; D Kimmig; R Smolarski; Alexander Kapp; Jörn Elsner
The biologic role of interleukin-8: functional analysis and expression of CXCR1 and CXCR2 on human eosinophils.
Blood 1999;93(2):694-702.
1998: Henrike L Schieferdecker; Sabine Pestel; E Rothermel; Gerhard P Püschel; Otto Götze; Kurt Jungermann
Stimulation by anaphylatoxin C5a of glycogen phosphorylase in rat hepatocytes via prostanoid release from hepatic stellate cells but not sinusoidal endothelial cells.
FEBS letters 1998;434(3):245-50.
1998: Jörg Zwirner; Thomas Werfel; HC Wilken; E Theile; Otto Götze
Anaphylatoxin C3a but not C3a(desArg) is a chemotaxin for the mouse macrophage cell line J774.
European journal of immunology 1998;28(5):1570-7.
1998: M Mohr; Uta E Höpken; Martin Oppermann; C Mathes; K Goldmann; S Siever; Otto Götze; Hilmar Burchardi
Effects of anti-C5a monoclonal antibodies on oxygen use in a porcine model of severe sepsis.
European journal of clinical investigation 1998;28(3):227-34.
1998: Jörg Zwirner; A Wittig; Elisabeth Kremmer; Otto Götze
A novel ELISA for the evaluation of the classical pathway of complement.
Journal of immunological methods 1998;211(1-2):183-90.
1998: Jörg Zwirner; Otto Götze; A Sieber; Alexander Kapp; G Begemann; T Zuberbier; Thomas Werfel
The human mast cell line HMC-1 binds and responds to C3a but not C3a(desArg).
Scandinavian journal of immunology 1998;47(1):19-24.
1997: Andreas Ludwig; Frank Petersen; S Zahn; Otto Götze; Jens Schröder; Hans-Dieter Flad; Ernst Brandt
The CXC-chemokine neutrophil-activating peptide-2 induces two distinct optima of neutrophil chemotaxis by differential interaction with interleukin-8 receptors CXCR-1 and CXCR-2.
Blood 1997;90(11):4588-97.
1997: Jörg Zwirner; Otto Götze; A Moser; A Sieber; G Begemann; Alexander Kapp; Jörn Elsner; Thomas Werfel
Blood- and skin-derived monocytes/macrophages respond to C3a but not to C3a(desArg) with a transient release of calcium via a pertussis toxin-sensitive signal transduction pathway.
European journal of immunology 1997;27(9):2317-22.
1997: E Rothermel; Jörg Zwirner; T Vogt; S Rabini; Otto Götze
Molecular cloning and expression of the functional rat C5a receptor.
Molecular immunology 1997;34(12-13):877-86.
1997: Henrike L Schieferdecker; E Rothermel; Arnd Timmermann; Otto Götze; Kurt Jungermann
Anaphylatoxin C5a receptor mRNA is strongly expressed in Kupffer and stellate cells and weakly in sinusoidal endothelial cells but not in hepatocytes of normal rat liver.
FEBS letters 1997;406(3):305-9.
1997: S Zahn; Jörg Zwirner; H P Spengler; Otto Götze
Chemoattractant receptors for interleukin-8 and C5a: expression on peripheral blood leukocytes and differential regulation on HL-60 and AML-193 cells by vitamin D3 and all-trans retinoic acid.
European journal of immunology 1997;27(4):935-40.
1997: Jörg Zwirner; Michael Burg; M Schulze; Reinhard Brunkhorst; Otto Götze; K M Koch; Jürgen Floege
Activated complement C3: a potentially novel predictor of progressive IgA nephropathy.
Kidney international 1997;51(4):1257-64.
1997: E Rothermel; O Rolf; Otto Götze; Jörg Zwirner
Nucleotide and corrected amino acid sequence of the functional recombinant rat anaphylatoxin C5a.
Biochimica et biophysica acta 1997;1351(1-2):9-12.
1997: Thomas Werfel; Martin Oppermann; G Begemann; Otto Götze; Jörg Zwirner
C5a receptors are detectable on mast cells in normal human skin and in psoriatic plaques but not in weal and flare reactions or in uticaria pigmentosa by immunohistochemistry.
Archives of dermatological research 1997;289(2):83-6.
1996: Gerhard P Püschel; A Nolte; Henrike L Schieferdecker; E Rothermel; Otto Götze; Kurt Jungermann
Inhibition of anaphylatoxin C3a- and C5a- but not nerve stimulation- or Noradrenaline-dependent increase in glucose output and reduction of flow in Kupffer cell-depleted perfused rat livers.
Hepatology (Baltimore, Md.) 1996;24(3):685-90.
1996: Thomas Werfel; Jörg Zwirner; Martin Oppermann; A Sieber; G Begemann; W Drommer; Alexander Kapp; Otto Götze
CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(4):1729-35.
1996: Thomas Werfel; Martin Oppermann; J H Butterfield; G Begemann; Jörn Elsner; Otto Götze; Jörg Zwirner
The human mast cell line HMC-1 expresses C5a receptors and responds to C5a but not to C5a(desArg).
Scandinavian journal of immunology 1996;44(1):30-6.
1996: U Höpken; M Mohr; A Strüber; H Montz; H Burchardi; Otto Götze; Martin Oppermann
Inhibition of interleukin-6 synthesis in an animal model of septic shock by anti-C5a monoclonal antibodies.
European journal of immunology 1996;26(5):1103-9.
1995: J P Kaiser; Martin Oppermann; Otto Götze; R Deppisch; H Göhl; G Asmus; B Röhrich; D von Herrath; K Schaefer
Significant reduction of factor D and immunosuppressive complement fragment Ba by hemofiltration.
Blood purification 1995;13(6):314-21.
1995: Jörg Zwirner; G Dobos; Otto Götze
A novel ELISA for the assessment of classical pathway of complement activation in vivo by measurement of C4-C3 complexes.
Journal of immunological methods 1995;186(1):55-63.
1995: U Hespeling; Gerhard P Püschel; Kurt Jungermann; Otto Götze; Jörg Zwirner
Stimulation of glycogen phosphorylase in rat hepatocytes via prostanoid release from Kupffer cells by recombinant rat anaphylatoxin C5a but not by native human C5a in hepatocyte/Kupffer cell co-cultures.
FEBS letters 1995;372(1):108-12.
1994: Martin Oppermann; Otto Götze
Plasma clearance of the human C5a anaphylatoxin by binding to leucocyte C5a receptors.
Immunology 1994;82(4):516-21.
1994: Martin Oppermann; Otto Götze
Characterization of physiologic breakdown products of the complement fragment Ba.
Molecular immunology 1994;31(4):307-14.
1993: Martin Oppermann; U Raedt; T Hebell; B Schmidt; B Zimmermann; Otto Götze
Probing the human receptor for C5a anaphylatoxin with site-directed antibodies. Identification of a potential ligand binding site on the NH2-terminal domain.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(7):3785-94.
1993: Torsten Witte; F L Dumoulin; J Engelbert Gessner; Jörg Schubert; Otto Götze; C Neumann; R F Todd; HR Deicher; Reinhold E Schmidt
Defect of a complement receptor 3 epitope in a patient with systemic lupus erythematosus.
The Journal of clinical investigation 1993;92(3):1181-7.
1992: Martin Oppermann; U Höpken; Otto Götze
Assessment of complement activation in vivo.
Immunopharmacology 1992;24(2):119-34.
1992: Torsten Witte; J Engelbert Gessner; Otto Götze; HR Deicher; Reinhold E Schmidt
[Complement receptor 3 deficiency in systematic lupus erythematosus].
Immunität und Infektion 1992;20(2):60-1.
1992: Reinhard Wurzner; MJ Hobart; Ann Orren; K Tokunaga; R Nitze; Otto Götze; Peter Lachmann
A novel protein polymorphism of human complement C7 detected by a monoclonal antibody.
Immunogenetics 1992;35(6):398-402.
1992: Thomas Werfel; Martin Oppermann; M Schulze; G Krieger; M Weber; Otto Götze
Binding of fluorescein-labeled anaphylatoxin C5a to human peripheral blood, spleen, and bone marrow leukocytes.
Blood 1992;79(1):152-60.
1991: Thomas Werfel; G Sonntag; M H Weber; Otto Götze
Rapid increases in the membrane expression of neutral endopeptidase (CD10), aminopeptidase N (CD13), tyrosine phosphatase (CD45), and Fc gamma-RIII (CD16) upon stimulation of human peripheral leukocytes with human C5a.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(11):3909-14.
1991: Martin Oppermann; C Kurts; R Zierz; E Quentin; M H Weber; Otto Götze
Elevated plasma levels of the immunosuppressive complement fragment Ba in renal failure.
Kidney international 1991;40(5):939-47.
1991: H Montz; K C Koch; R Zierz; Otto Götze
The role of C5a in interleukin-6 production induced by lipopolysaccharide or interleukin-1.
Immunology 1991;74(3):373-9.
1991: Thomas Werfel; W Witter; Otto Götze
CD11b and CD11c antigens are rapidly increased on human natural killer cells upon activation.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(7):2423-7.
1991: Reinhard Wurzner; H Xu; A Franzke; M Schulze; J H Peters; Otto Götze
Blood dendritic cells carry terminal complement complexes on their cell surface as detected by newly developed neoepitope-specific monoclonal antibodies.
Immunology 1991;74(1):132-8.
1991: Reinhard Wurzner; Peter Schuff-Werner; A Franzke; R Nitze; Martin Oppermann; Victor W Armstrong; T Eisenhauer; Dietrich Seidel; Otto Götze
Complement activation and depletion during LDL-apheresis by heparin-induced extracorporeal LDL-precipitation (HELP).
European journal of clinical investigation 1991;21(3):288-94.
1991: Gerhard P Püschel; Martin Oppermann; Frank Neuschäfer-Rube; Otto Götze; Kurt Jungermann
Differential effects of human anaphylatoxin C3a on glucose output and flow in rat liver during orthograde and retrograde perfusion: the periportal scavenger cell hypothesis.
Biochemical and biophysical research communications 1991;176(3):1218-26.
1991: Reinhard Wurzner; Ann Orren; P Potter; B P Morgan; D Ponard; P Späth; M Brai; M Schulze; L Happe; Otto Götze
Functionally active complement proteins C6 and C7 detected in C6- and C7-deficient individuals.
Clinical and experimental immunology 1991;83(3):430-7.
1991: Reinhard Wurzner; K Tokunaga; R Nitze; Otto Götze; Peter Lachmann
C7*N is a hypomorphic allele of the human complement c7 M/N protein polymorphism.
Experimental and clinical immunogenetics 1991;8(3):177-83.
1991: Reinhard Wurzner; M Schulze; L Happe; A Franzke; F A Bieber; Martin Oppermann; Otto Götze
Inhibition of terminal complement complex formation and cell lysis by monoclonal antibodies.
Complement and inflammation 1991;8(5-6):328-40.
1991: Martin Oppermann; M Schulze; Otto Götze
A sensitive enzyme immunoassay for the quantitation of human C5a/C5a(desArg) anaphylatoxin using a monoclonal antibody with specificity for a neoepitope.
Complement and inflammation 1991;8(1):13-24.
1990: Martin Oppermann; H Baumgarten; E Brandt; W Gottsleben; C Kurts; Otto Götze
Quantitation of components of the alternative pathway of complement (APC) by enzyme-linked immunosorbent assays.
Journal of immunological methods 1990;133(2):181-90.
1990: H Montz; A Fuhrmann; M Schulze; Otto Götze
Regulation of the human autologous T cell proliferation by endogenously generated C5a.
Cellular immunology 1990;127(2):337-51.
1990: Reinhard Wurzner; Martin Oppermann; R Zierz; H Baumgarten; Otto Götze
Determination of the epitope specificities of monoclonal antibodies using unprocessed supernatants of hybridoma cultures.
Journal of immunological methods 1990;126(2):231-7.
1990: Reinhard Wurzner; R Nitze; Otto Götze
C7*9, a new frequent C7 allele detected by an allotype-specific monoclonal antibody.
Complement and inflammation 1990;7(4-6):290-7.
1989: T Hebell; Otto Götze
The isolation of B lymphocytes from human peripheral blood using antibodies coupled to paramagnetic particles and rosetting techniques.
Journal of immunological methods 1989;123(2):283-91.
1989: Gerhard P Püschel; Martin Oppermann; W Muschol; Otto Götze; Kurt Jungermann
Increase of glucose and lactate output and decrease of flow by human anaphylatoxin C3a but not C5a in perfused rat liver.
FEBS letters 1989;243(1):83-7.
1989: M Bingel; W Arndt; M Schulze; Jürgen Floege; S Shaldon; Karl-Martin Koch; Otto Götze
Comparative study of C5a plasma levels with different hemodialysis membranes using an enzyme-linked immunosorbent assay.
Nephron 1989;51(3):320-4.
1988: Martin Oppermann; M Haubitz; E Quentin; Otto Götze
Complement activation in patients with renal failure as detected through the quantitation of fragments of the complement proteins C3, C5, and factor B.
Klinische Wochenschrift 1988;66(18):857-64.
1987: H Baumgarten; H Beulshausen; J Bätzing-Feigenbaum; F Bieber; R Zierz; Otto Götze
Determination of the T3-3A1 antigen in PHA-induced human T-cells by standardized cell-ELISA.
Journal of immunological methods 1987;96(2):201-9.