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Hannah Gould

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Chemicals & Drugs

Physiology

Immunoglobulin Class Switching

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Anna M Davies; Tamara H den Bleker; Hannah J Gould; James M McDonnell; Theo Rispens; Rob C Aalberse; Brian J Sutton
Crystal structure of the human IgG4 C(H)3 dimer reveals the role of Arg409 in the mechanism of Fab-arm exchange.
Philippe Gevaert; F Acke; Claus Bachert; G Banfield; N De Ruyck; Stephen R Durham; David J Fear; C E Harper; H H Kariyawasam; Kayhan T Nouri-Aria; Pooja Takhar; H Wu; Hannah J Gould
Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps.
Louisa K James; James M McDonnell; Mohamed H Shamji; Andrew John Beavil; Holly Bowen; Rosaleen A Calvert; Tihomir S Dodev; Stephen R Durham; Hannah J Gould
Allergen specificity of IgG(4)-expressing B cells in patients with grass pollen allergy undergoing immunotherapy.

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2013: Anna M Davies; Tamara H den Bleker; Hannah J Gould; James M McDonnell; Theo Rispens; Rob C Aalberse; Brian J Sutton
Crystal structure of the human IgG4 C(H)3 dimer reveals the role of Arg409 in the mechanism of Fab-arm exchange.
Molecular immunology 2013;54(1):1-7.
2013: Philippe Gevaert; F Acke; Claus Bachert; G Banfield; N De Ruyck; Stephen R Durham; David J Fear; C E Harper; H H Kariyawasam; Kayhan T Nouri-Aria; Pooja Takhar; H Wu; Hannah J Gould
Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps.
Allergy 2013;68(1):55-63.
2012: Louisa K James; James M McDonnell; Mohamed H Shamji; Andrew John Beavil; Holly Bowen; Rosaleen A Calvert; Tihomir S Dodev; Stephen R Durham; Hannah J Gould
Allergen specificity of IgG(4)-expressing B cells in patients with grass pollen allergy undergoing immunotherapy.
The Journal of allergy and clinical immunology 2012;130(3):663-670.e3.
2012: Sophia N Karagiannis; Alexander Koers; Frank O Nestle; Sarah M Rudman; Louise Saul; James F Spicer; Andrew John Beavil; Philip J Blower; Christopher Corrigan; Tihomir Dodev; Amy E Gilbert; Debra H Josephs; Panagiotis Karagiannis; Hannah J Gould
Recombinant IgE antibodies for passive immunotherapy of solid tumours: from concept towards clinical application.
Cancer immunology, immunotherapy : CII 2012;61(9):1547-64.
2012: Balvinder Dhaliwal; Stella M Fabiane; Hannah J Gould; Alistair J Henry; James M McDonnell; Amanda Oxbrow; Marie O Y Pang; Andrew John Beavil; Katharine Cain; Daopeng Yuan; Brian J Sutton
Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor FcεRI.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(31):12686-91.
2012: Alison M Cooper; Binia Drung; David J Fear; Philip S Hobson; Mark R Jutton; Michael W Kao; James M McDonnell; Boris Schmidt; Brian J Sutton; Andrew John Beavil; Hannah J Gould
Soluble CD23 controls IgE synthesis and homeostasis in human B cells.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(7):3199-207.
2012: Melissa Dullaers; Philippe Gevaert; Hannah J Gould; Ruth De Bruyne; Faruk Ramadani; Bart N Lambrecht
The who, where, and when of IgE in allergic airway disease.
The Journal of allergy and clinical immunology 2012;129(3):635-45.
2012: Jakub Nedbal; David J Fear; Rainer Heintzmann; Philip S Hobson; Hannah J Gould
Comprehensive FISH probe design tool applied to imaging human immunoglobulin class switch recombination.
PloS one 2012;7(12):e51675.
2012: Heather J Bax; Anthony H Keeble; Hannah J Gould
Cytokinergic IgE Action in Mast Cell Activation.
Frontiers in immunology 2012;3():229.
2011: Mary D Holdom; Anna M Davies; Joanne E Nettleship; Sarah C Bagby; Balvinder Dhaliwal; Enrico Girardi; James Hunt; Hannah J Gould; Andrew John Beavil; James M McDonnell; Ray J Owens; Brian J Sutton
Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI.
Nature structural & molecular biology 2011;18(5):571-6.
2011: Sandeep Dayal; Alison M Cooper; Gary Felsenfeld; Martin Gellert; Hannah J Gould; Philip Hobson; Jakub Nedbal; David J Fear
High resolution analysis of the chromatin landscape of the IgE switch region in human B cells.
PloS one 2011;6(9):e24571.
2011: N Zhang; G Holtappels; P Gevaert; J Patou; B Dhaliwal; Hannah J Gould; C Bachert
Mucosal tissue polyclonal IgE is functional in response to allergen and SEB.
Allergy 2011;66(1):141-8.
2008: James Hunt; Marguerite G Bracher; Jianguo Shi; Sébastien Fleury; David Dombrowicz; Hannah J Gould; Brian J Sutton; Andrew John Beavil
Attenuation of IgE affinity for FcepsilonRI radically reduces the allergic response in vitro and in vivo.
The Journal of biological chemistry 2008;283(44):29882-7.
2008: Muslima Chowdhury; Omid Forouhi; Sandeep Dayal; Natalie McCloskey; Hannah J Gould; Gary Felsenfeld; David J Fear
Analysis of intergenic transcription and histone modification across the human immunoglobulin heavy-chain locus.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(41):15872-7.
2008: Alexander Taylor; Hannah J Gould; Brian J Sutton; Rosaleen Ann Calvert
Avian IgY binds to a monocyte receptor with IgG-like kinetics despite an IgE-like structure.
The Journal of biological chemistry 2008;283(24):16384-90.
2008: Hannah J Gould; Brian J Sutton
IgE in allergy and asthma today.
Nature reviews. Immunology 2008;8(3):205-17.
2008: Sophia N Karagiannis; Marguerite G Bracher; Rebecca L Beavil; Andrew John Beavil; James Hunt; Natalie McCloskey; Richard G Thompson; Nick East; Frances Burke; Brian J Sutton; David Dombrowicz; Frances R Balkwill; Hannah J Gould
Role of IgE receptors in IgE antibody-dependent cytotoxicity and phagocytosis of ovarian tumor cells by human monocytic cells.
Cancer immunology, immunotherapy : CII 2008;57(2):247-63.
2007: Sophia N Karagiannis; Marguerite G Bracher; James Hunt; Natalie McCloskey; Rebecca L Beavil; Andrew John Beavil; David J Fear; Richard G Thompson; Nick East; Frances Burke; Robert J Moore; David Dombrowicz; Frances R Balkwill; Hannah J Gould
IgE-antibody-dependent immunotherapy of solid tumors: cytotoxic and phagocytic mechanisms of eradication of ovarian cancer cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(5):2832-43.
2007: Natalie McCloskey; James Hunt; Rebecca L Beavil; Mark R Jutton; Gabrielle J Grundy; Enrico Girardi; Stella M Fabiane; David J Fear; Daniel H Conrad; Brian J Sutton; Hannah J Gould
Soluble CD23 monomers inhibit and oligomers stimulate IGE synthesis in human B cells.
The Journal of biological chemistry 2007;282(33):24083-91.
2007: Marguerite G Bracher; Hannah J Gould; Brian J Sutton; David Dombrowicz; Sophia N Karagiannis
Three-colour flow cytometric method to measure antibody-dependent tumour cell killing by cytotoxicity and phagocytosis.
Journal of immunological methods 2007;323(2):160-71.
2007: Alexander Taylor; Hannah J Gould; Brian J Sutton; Rosaleen Ann Calvert
The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL.
Immunogenetics 2007;59(4):323-8.
2007: Hannah J Gould; Pooja Takhar; Helen E Harries; Elfy Chevretton; Brian J Sutton
The allergic march from Staphylococcus aureus superantigens to immunoglobulin E.
Chemical immunology and allergy 2007;93():106-36.
2007: Pooja Takhar; Christopher J Corrigan; Lyn Smurthwaite; Brian J O'connor; Stephen R Durham; Tak H Lee; Hannah J Gould
Class switch recombination to IgE in the bronchial mucosa of atopic and nonatopic patients with asthma.
The Journal of allergy and clinical immunology 2007;119(1):213-8.
2006: Hannah J Gould; Pooja Takhar; Helen E Harries; Stephen R Durham; Christopher J Corrigan
Germinal-centre reactions in allergic inflammation.
Trends in immunology 2006;27(10):446-52.
2006: Rengasamy Asokan; Jing Hua; Kendra A Young; Hannah J Gould; Jonathan P Hannan; Damian M Kraus; Gerda Szakonyi; Gabrielle J Grundy; Xiaojiang S Chen; Mary Crow; V Michael Holers
Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-alpha: a potential role in systemic lupus erythematosus.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(1):383-94.
2005: Richard G Hibbert; Peter Teriete; Gabrielle J Grundy; Rebecca L Beavil; Rajko Reljic; V Michael Holers; Jonathan P Hannan; Brian J Sutton; Hannah J Gould; James M McDonnell
The structure of human CD23 and its interactions with IgE and CD21.
The Journal of experimental medicine 2005;202(6):751-60.
2005: Heather A Coker; Helen E Harries; Graham K Banfield; Victoria A Carr; Stephen R Durham; Elfy Chevretton; Paul Hobby; Brian J Sutton; Hannah J Gould
Biased use of VH5 IgE-positive B cells in the nasal mucosa in allergic rhinitis.
The Journal of allergy and clinical immunology 2005;116(2):445-52.
2005: James Hunt; Rebecca L Beavil; Rosaleen Ann Calvert; Hannah J Gould; Brian J Sutton; Andrew John Beavil
Disulfide linkage controls the affinity and stoichiometry of IgE Fcepsilon3-4 binding to FcepsilonRI.
The Journal of biological chemistry 2005;280(17):16808-14.
2005: Pooja Takhar; Lyn Smurthwaite; Heather A Coker; David J Fear; Graham K Banfield; Victoria A Carr; Stephen R Durham; Hannah J Gould
Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):5024-32.
2005: Georgina Lang; Wendy M Gombert; Hannah J Gould
A transcriptional regulatory element in the coding sequence of the human Bcl-2 gene.
Immunology 2005;114(1):25-36.
2004: David J Fear; Natalie McCloskey; Brian O'Connor; Gary Felsenfeld; Hannah J Gould
Transcription of Ig germline genes in single human B cells and the role of cytokines in isotype determination.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(7):4529-38.
2003: Heather A Coker; Stephen R Durham; Hannah J Gould
Local somatic hypermutation and class switch recombination in the nasal mucosa of allergic rhinitis patients.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(10):5602-10.
2003: Sophia N Karagiannis; Qin Wang; Nick East; Frances Burke; Stephane Riffard; Marguerite G Bracher; Richard G Thompson; Stephen R Durham; Lawrence B Schwartz; Frances R Balkwill; Hannah J Gould
Activity of human monocytes in IgE antibody-dependent surveillance and killing of ovarian tumor cells.
European journal of immunology 2003;33(4):1030-40.
2003: Hannah J Gould; Brian J Sutton; Andrew John Beavil; Rebecca L Beavil; Natalie McCloskey; Heather A Coker; David J Fear; Lyn Smurthwaite
The biology of IGE and the basis of allergic disease.
Annual review of immunology 2003;21():579-628.
2002: Bing-Hung Chen; Check Ma; Timothy H Caven; Yee Chan-Li; Andrew Beavil; Rebecca L Beavil; Hannah J Gould; Daniel H Conrad
Necessity of the stalk region for immunoglobulin E interaction with CD23.
Immunology 2002;107(3):373-81.
2002: Tommy Wan; Rebecca L Beavil; Stella M Fabiane; Andrew John Beavil; Maninder K Sohi; Maura Keown; Robert J Young; Alistair J Henry; Ray J Owens; Hannah J Gould; Brian J Sutton
The crystal structure of IgE Fc reveals an asymmetrically bent conformation.
Nature immunology 2002;3(7):681-6.
2002: Graham A Mackay; Mark D Hulett; Justin P D Cook; Halina M Trist; Alistair J Henry; James M McDonnell; Andrew John Beavil; Rebecca L Beavil; Brian J Sutton; P Mark Hogarth; Hannah J Gould
Mutagenesis within human FcepsilonRIalpha differentially affects human and murine IgE binding.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1787-95.
2002: Duncan R Wilson; Terry G Merrett; Eva-Maria Varga; Lyn Smurthwaite; Hannah J Gould; Michael Kemp; James Hooper; Stephen Till; Stephen R Durham
Increases in allergen-specific IgE in BAL after segmental allergen challenge in atopic asthmatics.
American journal of respiratory and critical care medicine 2002;165(1):22-6.
2001: Lyn Smurthwaite; S N Walker; Duncan R Wilson; D S Birch; T G Merrett; Stephen R Durham; Hannah J Gould
Persistent IgE synthesis in the nasal mucosa of hay fever patients.
European journal of immunology 2001;31(12):3422-31.
2001: Michelle A Kilmon; R Ghirlando; M P Strub; Rebecca L Beavil; Hannah J Gould; Daniel H Conrad
Regulation of IgE production requires oligomerization of CD23.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(6):3139-45.
2001: Sophia N Karagiannis; J K Warrack; K H Jennings; PR Murdock; Graham R Christie; K Moulder; Brian J Sutton; Hannah J Gould
Endocytosis and recycling of the complex between CD23 and HLA-DR in human B cells.
Immunology 2001;103(3):319-31.
2001: James M McDonnell; Rosaleen Ann Calvert; Rebecca L Beavil; Andrew John Beavil; Alistair J Henry; Brian J Sutton; Hannah J Gould; David Cowburn
The structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalpha.
Nature structural biology 2001;8(5):437-41.
2001: Sun Ying; M Humbert; Qiu Meng; R Pfister; G Menz; Hannah J Gould; A Barry Kay; Stephen R Durham
Local expression of epsilon germline gene transcripts and RNA for the epsilon heavy chain of IgE in the bronchial mucosa in atopic and nonatopic asthma.
The Journal of allergy and clinical immunology 2001;107(4):686-92.
2000: Stephen R Durham; Lyn Smurthwaite; Hannah J Gould
Local IgE production.
American journal of rhinology 2000;14(5):305-7.
2000: Alistair J Henry; James M McDonnell; R Ghirlando; Brian J Sutton; Hannah J Gould
Conformation of the isolated cepsilon3 domain of IgE and its complex with the high-affinity receptor, FcepsilonRI.
Biochemistry 2000;39(25):7406-13.
2000: LJ Rigby; V C Epa; Graham A Mackay; Mark D Hulett; Brian J Sutton; Hannah J Gould; P Mark Hogarth
Domain one of the high affinity IgE receptor, FcepsilonRI, regulates binding to IgE through its interface with domain two.
The Journal of biological chemistry 2000;275(13):9664-72.
2000: EK Fridriksson; Andrew John Beavil; David Holowka; Hannah J Gould; Barbara Baird; Fred W McLafferty
Heterogeneous glycosylation of immunoglobulin E constructs characterized by top-down high-resolution 2-D mass spectrometry.
Biochemistry 2000;39(12):3369-76.
2000: Hannah J Gould; Rebecca L Beavil; Donata Vercelli
IgE isotype determination: epsilon-germline gene transcription, DNA recombination and B-cell differentiation.
British medical bulletin 2000;56(4):908-24.
1999: Hannah J Gould; G A Mackay; Sophia N Karagiannis; C M O'Toole; P J Marsh; B E Daniel; L R Coney; V R Zurawski; M Joseph; M Capron; M Gilbert; George F Murphy; Robert Korngold
Comparison of IgE and IgG antibody-dependent cytotoxicity in vitro and in a SCID mouse xenograft model of ovarian carcinoma.
European journal of immunology 1999;29(11):3527-37.
1999: Donald MacGlashan; Lawrence M Lichtenstein; J McKenzie-White; KRISTIN CHICHESTER; Alistair J Henry; Brian J Sutton; Hannah J Gould
Upregulation of FcepsilonRI on human basophils by IgE antibody is mediated by interaction of IgE with FcepsilonRI.
The Journal of allergy and clinical immunology 1999;104(2 Pt 1):492-8.
1998: Maura Keown; Alistair J Henry; R Ghirlando; Brian J Sutton; Hannah J Gould
Thermodynamics of the interaction of human immunoglobulin E with its high-affinity receptor Fc epsilon RI.
Biochemistry 1998;37(25):8863-9.
1997: Justin P D Cook; Alistair J Henry; James M McDonnell; Ray J Owens; Brian J Sutton; Hannah J Gould
Identification of contact residues in the IgE binding site of human FcepsilonRIalpha.
Biochemistry 1997;36(50):15579-88.
1997: Alistair J Henry; Justin P D Cook; James M McDonnell; Graham A Mackay; J Shi; Brian J Sutton; Hannah J Gould
Participation of the N-terminal region of Cepsilon3 in the binding of human IgE to its high-affinity receptor FcepsilonRI.
Biochemistry 1997;36(50):15568-78.
1997: Robert Korngold; B A Jameson; James M McDonnell; C Leighton; Brian J Sutton; Hannah J Gould; George F Murphy
Peptide analogs that inhibit IgE-Fc epsilon RI alpha interactions ameliorate the development of lethal graft-versus-host disease.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 1997;3(4):187-93.
1997: James M McDonnell; Andrew John Beavil; Graham A Mackay; Alistair J Henry; Justin P D Cook; Hannah J Gould; Brian J Sutton
Structure-based design of peptides that inhibit IgE binding to its high-affinity receptor Fc epsilon RI.
Biochemical Society transactions 1997;25(2):387-92.
1997: Stephen R Durham; Hannah J Gould; Qutayba A Hamid
Local IgE production in nasal allergy.
International archives of allergy and immunology 1997;113(1-3):128-30.
1997: O Schulz; Brian J Sutton; Rebecca L Beavil; J Shi; Herb F Sewell; Hannah J Gould; P Laing; Farouk Shakib
Cleavage of the low-affinity receptor for human IgE (CD23) by a mite cysteine protease: nature of the cleaved fragment in relation to the structure and function of CD23.
European journal of immunology 1997;27(3):584-8.
1997: J Shi; R Ghirlando; Rebecca L Beavil; Andrew John Beavil; Maura Keown; R J Young; Ray J Owens; Brian J Sutton; Hannah J Gould
Interaction of the low-affinity receptor CD23/Fc epsilonRII lectin domain with the Fc epsilon3-4 fragment of human immunoglobulin E.
Biochemistry 1997;36(8):2112-22.
1997: Maura Keown; R Ghirlando; Graham A Mackay; Brian J Sutton; Hannah J Gould
Basis of the 1:1 stoichiometry of the high affinity receptor Fc epsilon RI-IgE complex.
European biophysics journal : EBJ 1997;25(5-6):471-6.
1996: James M McDonnell; Andrew John Beavil; Graham A Mackay; B A Jameson; Robert Korngold; Hannah J Gould; Brian J Sutton
Structure based design and characterization of peptides that inhibit IgE binding to its high-affinity receptor.
Nature structural biology 1996;3(5):419-26.
1995: R Ghirlando; Maura Keown; Graham A Mackay; M S Lewis; J C Unkeless; Hannah J Gould
Stoichiometry and thermodynamics of the interaction between the Fc fragment of human IgG1 and its low-affinity receptor Fc gamma RIII.
Biochemistry 1995;34(41):13320-7.
1995: Maura Keown; R Ghirlando; R J Young; Andrew John Beavil; R J Owens; S J Perkins; Brian J Sutton; Hannah J Gould
Hydrodynamic studies of a complex between the Fc fragment of human IgE and a soluble fragment of the Fc epsilon RI alpha chain.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(6):1841-5.
1995: Rebecca L Beavil; P Graber; N Aubonney; J Y Bonnefoy; Hannah J Gould
CD23/Fc epsilon RII and its soluble fragments can form oligomers on the cell surface and in solution.
Immunology 1995;84(2):202-6.
1995: R J Young; R J Owens; Graham A Mackay; C M Chan; J Shi; M Hide; D M Francis; Alistair J Henry; Brian J Sutton; Hannah J Gould
Secretion of recombinant human IgE-Fc by mammalian cells and biological activity of glycosylation site mutants.
Protein engineering 1995;8(2):193-9.
1993: Brian J Sutton; Hannah J Gould
The human IgE network.
Nature 1993;366(6454):421-8.
1993: Andrew John Beavil; Rebecca L Beavil; C M Chan; Justin P D Cook; Hannah J Gould; Alistair J Henry; R J Owens; J Shi; Brian J Sutton; R J Young
Structural basis of the IgE-Fc epsilon RI interaction.
Biochemical Society transactions 1993;21(4):968-72.
1993: S E Dierks; W C Bartlett; R L Edmeades; Hannah J Gould; M Rao; Daniel H Conrad
The oligomeric nature of the murine Fc epsilon RII/CD23. Implications for function.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(6):2372-82.
1992: Andrew John Beavil; R L Edmeades; Hannah J Gould; Brian J Sutton
Alpha-helical coiled-coil stalks in the low-affinity receptor for IgE (Fc epsilon RII/CD23) and related C-type lectins.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(2):753-7.
1987: Hannah J Gould; Birgit A Helm; P J Marsh; R S Geha
Recombinant human IgE.
International archives of allergy and applied immunology 1987;82(3-4):392-3.
1985: J W Coleman; Birgit A Helm; D R Stanworth; Hannah J Gould
Inhibition of mast cell sensitization in vitro by a human immunoglobulin epsilon-chain fragment synthesized in Escherichia coli.
European journal of immunology 1985;15(9):966-9.