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Sandra Gould

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Dooseop Kim; Liping Wang; Jeffrey J Hale; Christopher L Lynch; Richard J Budhu; Malcolm MacCoss; Sander G Mills; Lorraine Malkowitz; Sandra L Gould; Julie A DeMartino; Martin S Springer; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee C Hrin; Gwen Carver; Anthony Carella; Karen Henry; Janet Lineberger; William A Schleif; Emilio A Emini
Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties.
Shrenik K Shah; Natalie Chen; Ravindra N Guthikonda; Sander G Mills; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini; Malcolm MacCoss
Synthesis and evaluation of CCR5 antagonists containing modified 4-piperidinyl-2-phenyl-1-(phenylsulfonylamino)-butane.
K Shankaran; Karla L Donnelly; Shrenik K Shah; Charles G Caldwell; Ping Chen; Paul E Finke; Bryan Oates; Malcolm MacCoss; Sander G Mills; Julie A DeMartino; Sandra L Gould; Lorraine Malkowitz; Salvatore J Siciliano; Martin S Springer; Gloria Y Kwei; Anthony Carella; Gwen Carver; Renee Danzeisen; Daria J Hazuda; Karen Holmes; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini; William A Schleif
Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists.

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All Publications

2005: Dooseop Kim; Liping Wang; Jeffrey J Hale; Christopher L Lynch; Richard J Budhu; Malcolm MacCoss; Sander G Mills; Lorraine Malkowitz; Sandra L Gould; Julie A DeMartino; Martin S Springer; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee C Hrin; Gwen Carver; Anthony Carella; Karen Henry; Janet Lineberger; William A Schleif; Emilio A Emini
Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties.
Bioorganic & medicinal chemistry letters 2005;15(8):2129-34.
2005: Shrenik K Shah; Natalie Chen; Ravindra N Guthikonda; Sander G Mills; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini; Malcolm MacCoss
Synthesis and evaluation of CCR5 antagonists containing modified 4-piperidinyl-2-phenyl-1-(phenylsulfonylamino)-butane.
Bioorganic & medicinal chemistry letters 2005;15(4):977-82.
2004: K Shankaran; Karla L Donnelly; Shrenik K Shah; Charles G Caldwell; Ping Chen; Paul E Finke; Bryan Oates; Malcolm MacCoss; Sander G Mills; Julie A DeMartino; Sandra L Gould; Lorraine Malkowitz; Salvatore J Siciliano; Martin S Springer; Gloria Y Kwei; Anthony Carella; Gwen Carver; Renee Danzeisen; Daria J Hazuda; Karen Holmes; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini; William A Schleif
Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists.
Bioorganic & medicinal chemistry letters 2004;14(13):3589-93.
2004: K Shankaran; Karla L Donnelly; Shrenik K Shah; Ravindra N Guthikonda; Malcolm MacCoss; Sander G Mills; Sandra L Gould; Lorraine Malkowitz; Salvatore J Siciliano; Martin S Springer; Anthony Carella; Gwen Carver; Daria J Hazuda; Karen Holmes; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini; William A Schleif
Syntheses and SAR studies of 4-(heteroarylpiperdin-1-yl-methyl)-pyrrolidin-1-yl-acetic acid antagonists of the human CCR5 chemokine receptor.
Bioorganic & medicinal chemistry letters 2004;14(13):3419-24.
2004: Min Shu; Jennifer L Loebach; Kerry A Parker; Sander G Mills; Kevin Chapman; Dong-Ming Shen; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Jerry Di Salvo; Kathryn Lyons; James V Pivnichny; Gloria Y Kwei; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment.
Bioorganic & medicinal chemistry letters 2004;14(4):947-52.
2004: Dong-Ming Shen; Min Shu; Christopher A Willoughby; Shrenik Shah; Christopher L Lynch; Jeffrey J Hale; Sander G Mills; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Kathryn Lyons; James V Pivnichny; Gloria Y Kwei; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds.
Bioorganic & medicinal chemistry letters 2004;14(4):941-5.
2004: Dong-Ming Shen; Min Shu; Sander G Mills; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Gloria Y Kwei; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains.
Bioorganic & medicinal chemistry letters 2004;14(4):935-9.
2003: Nadia M J Rupniak; Emma J Carlson; Sara Shepheard; Graham Bentley; Angela R Williams; Alastair Hill; Christopher J Swain; Sander G Mills; Jerry Di Salvo; Ruth Kilburn; Margaret A Cascieri; Marc M Kurtz; Kwei-Lan Tsao; Sandra L Gould; Gary G Chicchi
Comparison of the functional blockade of rat substance P (NK1) receptors by GR205171, RP67580, SR140333 and NKP-608.
Neuropharmacology 2003;45(2):231-41.
2003: Christopher L Lynch; Jeffrey J Hale; Richard J Budhu; Amy L Gentry; Paul E Finke; Charles G Caldwell; Sander G Mills; Malcolm MacCoss; Dong-Ming Shen; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
CCR5 antagonists: 3-(pyrrolidin-1-yl)propionic acid analogues with potent anti-HIV activity.
Organic letters 2003;5(14):2473-5.
2003: Christopher A Willoughby; Keith G Rosauer; Jeffrey J Hale; Richard J Budhu; Sander G Mills; Kevin Chapman; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
1,3,4 Trisubstituted pyrrolidine CCR5 receptor antagonists bearing 4-aminoheterocycle substituted piperidine side chains.
Bioorganic & medicinal chemistry letters 2003;13(3):427-31.
2003: Christopher L Lynch; Christopher A Willoughby; Jeffrey J Hale; Edward J Holson; Richard J Budhu; Amy L Gentry; Keith G Rosauer; Charles G Caldwell; Ping Chen; Sander G Mills; Malcolm MacCoss; Scott Berk; Liya Chen; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains.
Bioorganic & medicinal chemistry letters 2003;13(1):119-23.
2002: Christopher L Lynch; Jeffrey J Hale; Richard J Budhu; Amy L Gentry; Sander G Mills; Kevin Chapman; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV.
Bioorganic & medicinal chemistry letters 2002;12(20):3001-4.
2002: Jeffrey J Hale; Richard J Budhu; Sander G Mills; Malcolm MacCoss; Sandra L Gould; Julie A DeMartino; Martin S Springer; Salvatore J Siciliano; Lorraine Malkowitz; William A Schleif; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee Danzeisen; Karen Holmes; Janet Lineberger; Anthony Carella; Gwen Carver; Emilio A Emini
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 3: polar functionality and its effect on anti-HIV-1 activity.
Bioorganic & medicinal chemistry letters 2002;12(20):2997-3000.
2002: Christopher L Lynch; Amy L Gentry; Jeffrey J Hale; Sander G Mills; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; George A Doss; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
CCR5 antagonists: bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines.
Bioorganic & medicinal chemistry letters 2002;12(4):677-9.
2001: Christopher A Willoughby; Scott Berk; Keith G Rosauer; SJ Degrado; Kevin Chapman; Sandra L Gould; Martin S Springer; Lorraine Malkowitz; William A Schleif; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee Danzeisen; Karen Holmes; Janet Lineberger; Anthony Carella; Gwen Carver; Emilio A Emini
Combinatorial synthesis of CCR5 antagonists.
Bioorganic & medicinal chemistry letters 2001;11(24):3137-41.
2001: Dooseop Kim; Liping Wang; Charles G Caldwell; Ping Chen; Paul E Finke; Bryan Oates; Malcolm MacCoss; Sander G Mills; Lorraine Malkowitz; Sandra L Gould; Julie A DeMartino; Martin S Springer; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee Danzeisen; Gwen Carver; Anthony Carella; Karen Holmes; Janet Lineberger; William A Schleif; Emilio A Emini
Design, synthesis, and SAR of heterocycle-containing antagonists of the human CCR5 receptor for the treatment of HIV-1 infection.
Bioorganic & medicinal chemistry letters 2001;11(24):3103-6.
2001: Dooseop Kim; Liping Wang; Charles G Caldwell; Ping Chen; Paul E Finke; Bryan Oates; Malcolm MacCoss; Sander G Mills; Lorraine Malkowitz; Sandra L Gould; Julie A DeMartino; Martin S Springer; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee Danzeisen; Gwen Carver; Anthony Carella; Karen Holmes; Janet Lineberger; William A Schleif; Emilio A Emini
Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection.
Bioorganic & medicinal chemistry letters 2001;11(24):3099-102.
2001: Jeffrey J Hale; Richard J Budhu; E B Holson; Paul E Finke; Bryan Oates; Sander G Mills; Malcolm MacCoss; Sandra L Gould; Julie A DeMartino; Martin S Springer; Salvatore J Siciliano; Lorraine Malkowitz; William A Schleif; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee Danzeisen; Karen Holmes; Janet Lineberger; Anthony Carella; Gwen Carver; Emilio A Emini
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent anti-HIV activity.
Bioorganic & medicinal chemistry letters 2001;11(20):2741-5.
2001: Paul E Finke; Bryan Oates; Sander G Mills; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Anthony Carella; Gwen Carver; Karen Holmes; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; William A Schleif; Emilio A Emini
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure-activity relationships for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes.
Bioorganic & medicinal chemistry letters 2001;11(18):2475-9.
2001: Paul E Finke; Laura C Meurer; Bryan Oates; Shrenik K Shah; J L Loebach; Sander G Mills; Malcolm MacCoss; Laurie A Castonguay; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 3: a proposed pharmacophore model for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-[4-(substituted)piperidin-1-yl]butanes.
Bioorganic & medicinal chemistry letters 2001;11(18):2469-73.
2001: Jeffrey J Hale; Richard J Budhu; Sander G Mills; Malcolm MacCoss; Lorraine Malkowitz; Salvatore J Siciliano; Sandra L Gould; Julie A DeMartino; Martin S Springer
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements.
Bioorganic & medicinal chemistry letters 2001;11(11):1437-40.
2001: Irwin I Singer; S Scott; Douglas W Kawka; J Chin; Bruce L Daugherty; Julie A DeMartino; J DiSalvo; Sandra L Gould; Janet Lineberger; Lorraine Malkowitz; M D Miller; L Mitnaul; Salvatore J Siciliano; Mary Jo Staruch; HR Williams; Hans Zweerink; Martin S Springer
CCR5, CXCR4, and CD4 are clustered and closely apposed on microvilli of human macrophages and T cells.
Journal of virology 2001;75(8):3779-90.
2001: Paul E Finke; Laura C Meurer; Bryan Oates; Sander G Mills; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Bruce L Daugherty; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Anthony Carella; Gwen Carver; Karen Holmes; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; William A Schleif; Emilio A Emini
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 2: structure-activity relationships for substituted 2-Aryl-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-(piperidin-1-yl)butanes.
Bioorganic & medicinal chemistry letters 2001;11(2):265-70.
2001: C P Dorn; Paul E Finke; Bryan Oates; Richard J Budhu; Sander G Mills; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Bruce L Daugherty; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Anthony Carella; Gwen Carver; Karen Holmes; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; William A Schleif; Emilio A Emini
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. part 1: discovery and initial structure-activity relationships for 1 -amino-2-phenyl-4-(piperidin-1-yl)butanes.
Bioorganic & medicinal chemistry letters 2001;11(2):259-64.
1998: Y Weng; Salvatore J Siciliano; K E Waldburger; A Sirotina-Meisher; Mary Jo Staruch; Bruce L Daugherty; Sandra L Gould; Martin S Springer; Julie A DeMartino
Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
The Journal of biological chemistry 1998;273(29):18288-91.