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Gunnar Gouras

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Gunnar K Gouras
mTOR: at the crossroads of aging, chaperones, and Alzheimer's disease.
Reisuke H Takahashi; Estibaliz Capetillo-Zarate; Michael T Lin; Teresa A Milner; Gunnar K Gouras
Accumulation of intraneuronal β-amyloid 42 peptides is associated with early changes in microtubule-associated protein 2 in neurites and synapses.
Gunnar K Gouras; Katarina Willén; Davide Tampellini
Critical role of intraneuronal Aβ in Alzheimer's disease: technical challenges in studying intracellular Aβ.

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All Publications

2013: Gunnar K Gouras
mTOR: at the crossroads of aging, chaperones, and Alzheimer's disease.
Journal of neurochemistry 2013;124(6):747-8.
2013: Reisuke H Takahashi; Estibaliz Capetillo-Zarate; Michael T Lin; Teresa A Milner; Gunnar K Gouras
Accumulation of intraneuronal β-amyloid 42 peptides is associated with early changes in microtubule-associated protein 2 in neurites and synapses.
PloS one 2013;8(1):e51965.
2012: Gunnar K Gouras; Katarina Willén; Davide Tampellini
Critical role of intraneuronal Aβ in Alzheimer's disease: technical challenges in studying intracellular Aβ.
Life sciences 2012;91(23-24):1153-8.
2012: Shira Knafo; Gunnar K Gouras; Xiao-Xin Yan; Tara Spires-Jones
Pathology of synapses and dendritic spines.
Neural plasticity 2012;2012():972432.
2012: Estibaliz Capetillo-Zarate; Luis Gracia; Davide Tampellini; Gunnar K Gouras
Intraneuronal Aβ accumulation, amyloid plaques, and synapse pathology in Alzheimer's disease.
Neuro-degenerative diseases 2012;10(1-4):56-9.
2011: Estibaliz Capetillo-Zarate; Jason R Banfelder; Luis Gracia; Michael T Lin; Davide Tampellini; Fangmin Yu; Gunnar K Gouras
High-resolution 3D reconstruction reveals intra-synaptic amyloid fibrils.
The American journal of pathology 2011;179(5):2551-8.
2011: Davide Tampellini; Estibaliz Capetillo-Zarate; Michael T Lin; Nawreen Rahman; Gunnar K Gouras
Impaired β-amyloid secretion in Alzheimer's disease pathogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(43):15384-90.
2011: Reisuke H Takahashi; Minoru Tobiume; Yuko Sato; Tetsutaro Sata; Gunnar K Gouras; Hidehiro Takahashi
Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain.
Neuropathology : official journal of the Japanese Society of Neuropathology 2011;31(3):208-14.
2011: Amitabha Majumdar; Estibaliz Capetillo-Zarate; Dana Cruz; Gunnar K Gouras; Frederick R Maxfield
Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes.
Molecular biology of the cell 2011;22(10):1664-76.
2011: Davide Tampellini; Gunnar K Gouras
Analysis of vesicular trafficking in primary neurons by live imaging.
Methods in molecular biology (Clifton, N.J.) 2011;793():343-50.
2011: Magali Dumont; Gunnar K Gouras; Maya Katz; Khatuna Kipiani; Michael T Lin; Elizabeth Wille; Fangmin Yu; Noel Y Calingasan; M Flint Beal
Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2011;27(1):211-23.
2010: Davide Tampellini; Estibaliz Capetillo-Zarate; Magali Dumont; Zhenyong Huang; Fangmin Yu; Michael T Lin; Gunnar K Gouras
Effects of synaptic modulation on beta-amyloid, synaptophysin, and memory performance in Alzheimer's disease transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(43):14299-304.
2010: Reisuke H Takahashi; Estibaliz Capetillo-Zarate; Michael T Lin; Teresa A Milner; Gunnar K Gouras
Co-occurrence of Alzheimer's disease ß-amyloid and τ pathologies at synapses.
Neurobiology of aging 2010;31(7):1145-52.
2010: Gunnar K Gouras; Davide Tampellini; Reisuke H Takahashi; Estibaliz Capetillo-Zarate
Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease.
Acta neuropathologica 2010;119(5):523-41.
2010: Tao Ma; Charles Albert Hoeffer; Estibaliz Capetillo-Zarate; Fangmin Yu; Helen Wong; Michael T Lin; Davide Tampellini; Eric Klann; Robert D Blitzer; Gunnar K Gouras
Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease.
PloS one 2010;5(9):.
2010: Davide Tampellini; Gunnar K Gouras
Synapses, synaptic activity and intraneuronal abeta in Alzheimer's disease.
Frontiers in aging neuroscience 2010;2():.
2009: Davide Tampellini; Nawreen Rahman; Eduardo F Gallo; Zhenyong Huang; Magali Dumont; Estibaliz Capetillo-Zarate; Tao Ma; Rong Zheng; Bao Lu; David M Nanus; Michael T Lin; Gunnar K Gouras
Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(31):9704-13.
2009: Magali Dumont; Elizabeth Wille; Noel Y Calingasan; Davide Tampellini; Charlotte Williams; Gunnar K Gouras; Karen Liby; Michael B. Sporn; Carl Nathan; M Flint Beal; Michael T Lin
Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease.
Journal of neurochemistry 2009;109(2):502-12.
2009: Alex C Kwan; karen duff; Gunnar K Gouras; Watt W Webb
Optical visualization of Alzheimer's pathology via multiphoton-excited intrinsic fluorescence and second harmonic generation.
Optics express 2009;17(5):3679-89.
2009: Gunnar K Gouras
Immunotherapy for Alzheimer disease.
mAbs 2009;1(2):112-4.
2007: Deepa V Venkitaramani; Jeannie Chin; William Netzer; Gunnar K Gouras; Sylvain Lesne; Roberto Malinow; Paul J Lombroso
Beta-amyloid modulation of synaptic transmission and plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(44):11832-7.
2007: Davide Tampellini; Jordi Magrané; Reisuke H Takahashi; Feng Li; Michael T Lin; Claudia Almeida; Gunnar K Gouras
Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations.
The Journal of biological chemistry 2007;282(26):18895-906.
2007: Charlotte Sahlin; Anna Lord; Kristina Magnusson; Hillevi Englund; Claudia Almeida; Paul Greengard; Fred Nyberg; Gunnar K Gouras; Lars Lannfelt; Lars N G Nilsson
The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase.
Journal of neurochemistry 2007;101(3):854-62.
2006: Claudia Almeida; Reisuke H Takahashi; Gunnar K Gouras
Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(16):4277-88.
2006: Gunnar K Gouras; Howard Fillit
Neurogenesis as a therapeutic strategy for cognitive aging and Alzheimer's disease.
Current Alzheimer research 2006;3(1):3.
2005: Jordi Magrané; Kenneth M Rosen; Roy Smith; Kenneth Walsh; Gunnar K Gouras; Henry Querfurth
Intraneuronal beta-amyloid expression downregulates the Akt survival pathway and blunts the stress response.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(47):10960-9.
2005: Claudia Almeida; Davide Tampellini; Reisuke H Takahashi; Paul Greengard; Michael T Lin; Eric M Snyder; Gunnar K Gouras
Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses.
Neurobiology of disease 2005;20(2):187-98.
2005: Gunnar K Gouras; Claudia Almeida; Reisuke H Takahashi
Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease.
Neurobiology of aging 2005;26(9):1235-44.
2005: Eric M Snyder; Yi Nong; Claudia Almeida; Surojit Paul; Timothy Moran; Eun Young Choi; Angus Nairn; Michael W Salter; Paul J Lombroso; Gunnar K Gouras; Paul Greengard
Regulation of NMDA receptor trafficking by amyloid-beta.
Nature neuroscience 2005;8(8):1051-8.
2005: Carlos A Saura; Guiquan Chen; Seema Malkani; Se-Young Choi; Reisuke H Takahashi; Dawei Zhang; Gunnar K Gouras; Alfredo Kirkwood; Richard G M Morris; Jie Shen
Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(29):6755-64.
2005: Charlotte Stenh; Hillevi Englund; Anna Lord; Ann-Sofi Johansson; Claudia Almeida; Pär Gellerfors; Paul Greengard; Gunnar K Gouras; Lars Lannfelt; Lars N G Nilsson
Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay.
Annals of neurology 2005;58(1):147-50.
2005: Marc E Weksler; Gunnar K Gouras; Norman Richard Relkin; Paul Szabo
The immune system, amyloid-beta peptide, and Alzheimer's disease.
Immunological reviews 2005;205():244-56.
2004: Feng Li; Noel Y Calingasan; Fangmin Yu; William M Mauck; Marine Toidze; Claudia Almeida; Reisuke H Takahashi; George A Carlson; M Flint Beal; Michael T Lin; Gunnar K Gouras
Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.
Journal of neurochemistry 2004;89(5):1308-12.
2004: Reisuke H Takahashi; Claudia Almeida; Patrick F Kearney; Fangmin Yu; Michael T Lin; Teresa A Milner; Gunnar K Gouras
Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(14):3592-9.
2003: Larry Goldstein; J Wesson Ashford; Jorge Busciglio; keith crutcher; Gunnar K Gouras; June Kinoshita; Eckhard Mandelkow; Marius Sudol
Live discussion. From here to there: AbetaPP as an axonal transport receptor--how could this explain neurodegeneration in AD. 15 July 2002.
Journal of Alzheimer's disease : JAD 2003;5(6):483-9.
2003: Fei Dou; William Netzer; Kentaro Tanemura; Feng Li; F Ulrich Hartl; Akihiko Takashima; Gunnar K Gouras; Paul Greengard; Huaxi Xu
Chaperones increase association of tau protein with microtubules.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(2):721-6.
2002: Reisuke H Takahashi; Teresa A Milner; Feng Li; Ellen E Nam; Mark A Edgar; Haruyasu Yamaguchi; M Flint Beal; Huaxi Xu; Paul Greengard; Gunnar K Gouras
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology.
The American journal of pathology 2002;161(5):1869-79.
2002: Reisuke H Takahashi; E E Nam; Mark A Edgar; Gunnar K Gouras
Alzheimer beta-amyloid peptides: normal and abnormal localization.
Histology and histopathology 2002;17(1):239-46.
2001: Gunnar K Gouras; M Flint Beal
Metal chelator decreases Alzheimer beta-amyloid plaques.
Neuron 2001;30(3):641-2.
2001: L Gasparini; Gunnar K Gouras; Runsheng Wang; Rachel S Gross; M Flint Beal; Paul Greengard; Huaxi Xu
Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(8):2561-70.
2000: Gunnar K Gouras; Huaxi Xu; Rachel S Gross; Jeffrey P Greenfield; B Hai; Runsheng Wang; Paul Greengard
Testosterone reduces neuronal secretion of Alzheimer's beta-amyloid peptides.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(3):1202-5.
2000: Jeffrey P Greenfield; Rachel S Gross; Gunnar K Gouras; Huaxi Xu
Cellular and molecular basis of beta-amyloid precursor protein metabolism.
Frontiers in bioscience : a journal and virtual library 2000;5():D72-83.
2000: Gunnar K Gouras; J Tsai; J Naslund; B Vincent; Mark A Edgar; F Checler; Jeffrey P Greenfield; Vahram Haroutunian; Joseph Buxbaum; Huaxi Xu; Paul Greengard; Norman Richard Relkin
Intraneuronal Abeta42 accumulation in human brain.
The American journal of pathology 2000;156(1):15-20.
1999: Jeffrey P Greenfield; J Tsai; Gunnar K Gouras; B Hai; Gopal Thinakaran; F Checler; Sangram S Sisodia; Paul Greengard; Huaxi Xu
Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):742-7.
1998: Gunnar K Gouras; H Xu; J N Jovanovic; Joseph Buxbaum; Rong Wang; Paul Greengard; Norman Richard Relkin; Sam Gandy
Generation and regulation of beta-amyloid peptide variants by neurons.
Journal of neurochemistry 1998;71(5):1920-5.
1998: Huaxi Xu; Gunnar K Gouras; Jeffrey P Greenfield; B Vincent; J Naslund; L Mazzarelli; G Fried; J N Jovanovic; M Seeger; Norman Richard Relkin; F Liao; F Checler; Joseph Buxbaum; Brian T Chait; Gopal Thinakaran; Sangram S Sisodia; Runsheng Wang; Paul Greengard; Sam Gandy
Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.
Nature medicine 1998;4(4):447-51.
1998: Jeffrey P Greenfield; Gunnar K Gouras; Huaxi Xu
Cellular and molecular basis of beta-amyloid precursor protein metabolism.
Frontiers in bioscience : a journal and virtual library 1998;3():d399-407.
1997: M Seeger; C Nordstedt; Suzana Petanceska; Dora M. Kovacs; Gunnar K Gouras; S Hahne; Paul E Fraser; L Levesque; Andrew J Czernik; Peter St George-Hyslop; Sangram S Sisodia; Gopal Thinakaran; Rudolph E Tanzi; Paul Greengard; Sam Gandy
Evidence for phosphorylation and oligomeric assembly of presenilin 1.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5090-4.
1997: Gunnar K Gouras; Norman Richard Relkin; D Sweeney; D G Munoz; I R Mackenzie; Sam Gandy
Increased apolipoprotein E epsilon 4 in epilepsy with senile plaques.
Annals of neurology 1997;41(3):402-4.
1996: Michael Gordon Kaplitt; Gunnar K Gouras; H Makimura; J Jovanovic; D Sweeney; Paul Greengard; Norman Richard Relkin; Sam Gandy
Apolipoprotein E, A beta-amyloid, and the molecular pathology of Alzheimer's disease. Therapeutic implications.
Annals of the New York Academy of Sciences 1996;802():42-9.
1996: Norman Richard Relkin; M A Edgar; Gunnar K Gouras; Sam Gandy; H S Goldsmith
Decreased senile plaque density in Alzheimer neocortex adjacent to an omental transposition.
Neurological research 1996;18(4):291-4; discussion 295-6.
1996: Seward B Rutkove; U De Girolami; David C Preston; R Freeman; Rachel A Nardin; Gunnar K Gouras; Donald R Johns; Elizabeth M Raynor
Myotonia in colchicine myoneuropathy.
Muscle & nerve 1996;19(7):870-5.
1996: W D Lagreze; J E Warner; A A Zamani; Gunnar K Gouras; I J Koralnik; D C Bienfang
Mesencephalic clefts with associated eye movement disorders.
Archives of ophthalmology 1996;114(4):429-32.
1994: Vassilis E Koliatsos; Donald L Price; Gunnar K Gouras; M H Cayouette; L E Burton; JW Winslow
Highly selective effects of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 on intact and injured basal forebrain magnocellular neurons.
The Journal of comparative neurology 1994;343(2):247-62.
1992: Gunnar K Gouras; Naomi E Rance; W Scott Young; Vassilis E Koliatsos
Tyrosine-hydroxylase-containing neurons in the primate basal forebrain magnocellular complex.
Brain research 1992;584(1-2):287-93.
1991: Vassilis E Koliatsos; R E Clatterbuck; Gunnar K Gouras; Donald L Price
Biologic effects of nerve growth factor on lesioned basal forebrain neurons.
Annals of the New York Academy of Sciences 1991;640():102-9.