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Henriette Gourdeau

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T Bertomeu; V Zvereff; A Ibrahim; S P Zehntner; A Aliaga; P Rosa-Neto; B J Bedell; Pierre Falardeau; Henriette Gourdeau
TLN-4601 peripheral benzodiazepine receptor (PBR/TSPO) binding properties do not mediate apoptosis but confer tumor-specific accumulation.
Nadia Boufaied; My-Anh Wioland; Pierre Falardeau; Henriette Gourdeau
TLN-4601, a novel anticancer agent, inhibits Ras signaling post Ras prenylation and before MEK activation.
Paul M Campbell; Nadia Boufaied; James J Fiordalisi; Adrienne D Cox; Pierre Falardeau; Channing J Der; Henriette Gourdeau
TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling.

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All Publications

2010: T Bertomeu; V Zvereff; A Ibrahim; S P Zehntner; A Aliaga; P Rosa-Neto; B J Bedell; Pierre Falardeau; Henriette Gourdeau
TLN-4601 peripheral benzodiazepine receptor (PBR/TSPO) binding properties do not mediate apoptosis but confer tumor-specific accumulation.
Biochemical pharmacology 2010;80(10):1572-9.
2010: Nadia Boufaied; My-Anh Wioland; Pierre Falardeau; Henriette Gourdeau
TLN-4601, a novel anticancer agent, inhibits Ras signaling post Ras prenylation and before MEK activation.
Anti-cancer drugs 2010;21(5):543-52.
2010: Paul M Campbell; Nadia Boufaied; James J Fiordalisi; Adrienne D Cox; Pierre Falardeau; Channing J Der; Henriette Gourdeau
TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling.
Journal of molecular signaling 2010;5():18.
2009: Arjun H Banskota; Mustapha Aouidate; Dan Sørensen; Ashraf Ibrahim; Mahmood Piraee; Emmanuel Zazopoulos; Anne-Marie Alarco; Henriette Gourdeau; Christophe Mellon; Chris M Farnet; Pierre Falardeau; James B McAlpine
TLN-05220, TLN-05223, new Echinosporamicin-type antibiotics, and proposed revision of the structure of bravomicins(*).
The Journal of antibiotics 2009;62(10):565-70.
2008: William Kemnitzer; Songchun Jiang; Hong Zhang; Shailaja Kasibhatla; Candace Crogan-Grundy; Charles Blais; Giorgio Attardo; Real Denis; Serge Lamothe; Henriette Gourdeau; Ben Tseng; John Drewe; Sui Xiong Cai
Discovery of 4-aryl-2-oxo-2H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay.
Bioorganic & medicinal chemistry letters 2008;18(20):5571-5.
2008: Henriette Gourdeau; James B McAlpine; Maxime Ranger; Bryan Simard; Francois Berger; Francis Beaudry; Chris M Farnet; Pierre Falardeau
Identification, characterization and potent antitumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand.
Cancer chemotherapy and pharmacology 2008;61(6):911-21.
2008: William Kemnitzer; John Drewe; Songchun Jiang; Hong Zhang; Candace Crogan-Grundy; Denis Labreque; Monica Bubenick; Giorgio Attardo; Réal Denis; Serge Lamothe; Henriette Gourdeau; Ben Tseng; Shailaja Kasibhatla; Sui Xiong Cai
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions.
Journal of medicinal chemistry 2008;51(3):417-23.
2008: William Kemnitzer; Songchun Jiang; Yan Wang; Shailaja Kasibhatla; Candace Crogan-Grundy; Monica Bubenik; Denis Labrecque; Réal Denis; Serge Lamothe; Giorgio Attardo; Henriette Gourdeau; Ben Tseng; John Drewe; Sui Xiong Cai
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based HTS assay. Part 5: modifications of the 2- and 3-positions.
Bioorganic & medicinal chemistry letters 2008;18(2):603-7.
2007: William Kemnitzer; John Drewe; Songchun Jiang; Hong Zhang; Jianghong Zhao; Candace Crogan-Grundy; Lifen Xu; Serge Lamothe; Henriette Gourdeau; Réal Denis; Ben Tseng; Shailaja Kasibhatla; Sui Xiong Cai
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 3. Structure-activity relationships of fused rings at the 7,8-positions.
Journal of medicinal chemistry 2007;50(12):2858-64.
2007: Jia-Chi Wang; Louis R Bégin; Nathalie G Bérubé; Simone Chevalier; Armen G Aprikian; Henriette Gourdeau; Mario Chevrette
Down-regulation of CD9 expression during prostate carcinoma progression is associated with CD9 mRNA modifications.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(8):2354-61.
2007: Vijaya L Damaraju; David Y Bouffard; Clarence K W Wong; Marilyn Lesley Clarke; John R Mackey; Lorraine Leblond; Carol E Cass; Mike Grey; Henriette Gourdeau
Synergistic activity of troxacitabine (Troxatyl) and gemcitabine in pancreatic cancer.
BMC cancer 2007;7():121.
2005: William Kemnitzer; Shailaja Kasibhatla; Songchun Jiang; Hong Zhang; Jianghong Zhao; Shaojuan Jia; Lifen Xu; Candace Crogan-Grundy; Réal Denis; Nancy Barriault; Louis Vaillancourt; Sylvie Charron; Jennifer Dodd; Giorgio Attardo; Denis Labrecque; Serge Lamothe; Henriette Gourdeau; Ben Tseng; John Drewe; Sui Xiong Cai
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions.
Bioorganic & medicinal chemistry letters 2005;15(21):4745-51.
2004: William Kemnitzer; John Drewe; Songchun Jiang; Hong Zhang; Yan Wang; Jianghong Zhao; Shaojuan Jia; John Herich; Denis Labreque; Richard Storer; Karen Meerovitch; David Y Bouffard; Rabindra Rej; Réal Denis; Charles Blais; Serge Lamothe; Giorgio Attardo; Henriette Gourdeau; Ben Tseng; Shailaja Kasibhatla; Sui Xiong Cai
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the 4-aryl group.
Journal of medicinal chemistry 2004;47(25):6299-310.
2004: Henriette Gourdeau; Lorraine Leblond; Bettina Hamelin; Kelly Dong; France Ouellet; Chantal Boudreau; Dominique Custeau; Annie Richard; Marie-Josée Gilbert; Jacques Jolivet
Species differences in troxacitabine pharmacokinetics and pharmacodynamics: implications for clinical development.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(22):7692-702.
2004: Henriette Gourdeau; Lorraine Leblond; Bettina Hamelin; Clemence Desputeau; Kelly Dong; Irenej Kianicka; Dominique Custeau; Chantal Boudreau; Lilianne Geerts; Sui Xiong Cai; John Drewe; Denis Labrecque; Shailaja Kasibhatla; Ben Tseng
Antivascular and antitumor evaluation of 2-amino-4-(3-bromo-4,5-dimethoxy-phenyl)-3-cyano-4H-chromenes, a novel series of anticancer agents.
Molecular cancer therapeutics 2004;3(11):1375-84.
2004: Shailaja Kasibhatla; Henriette Gourdeau; Karen Meerovitch; John Drewe; Sanjeeva Reddy; Ling Qiu; Hong Zhang; Frederick Bergeron; David Y Bouffard; Quan Yang; John Herich; Serge Lamothe; Sui Xiong Cai; Ben Tseng
Discovery and mechanism of action of a novel series of apoptosis inducers with potential vascular targeting activity.
Molecular cancer therapeutics 2004;3(11):1365-74.
2004: Henriette Gourdeau; Jacques Jolivet
[Troxacitabine].
Bulletin du cancer 2004;91(3):213-8.
2004: Nada Orsolic; Francis Giles; Henriette Gourdeau; Mirna Golemovic; Miloslav Beran; Jorge Cortes; Emil J Freireich; Andrew Lamb; Srdan Verstovsek
Troxacitabine and imatinib mesylate combination therapy of chronic myeloid leukaemia: preclinical evaluation.
British journal of haematology 2004;124(6):727-38.
2004: Anne-Julie Boivin; Henriette Gourdeau; Richard L Momparler
Action of troxacitabine on cells transduced with human cytidine deaminase cDNA.
Cancer investigation 2004;22(1):25-9.
2003: David Y Bouffard; Jacques Jolivet; Lorraine Leblond; Bettina Hamelin; France Ouellet; Sylvain Barbeau; Annie Richard; Henriette Gourdeau
Complementary antineoplastic activity of the cytosine nucleoside analogues troxacitabine (Troxatyl) and cytarabine in human leukemia cells.
Cancer chemotherapy and pharmacology 2003;52(6):497-506.
2003: Karen Meerovitch; Frédéric Bergeron; Lorraine Leblond; Brigitte Grouix; Cathy Poirier; Monica Bubenik; Laval Chan; Henriette Gourdeau; Terry Bowlin; Giorgio Attardo
A novel RGD antagonist that targets both alphavbeta3 and alpha5beta1 induces apoptosis of angiogenic endothelial cells on type I collagen.
Vascular pharmacology 2003;40(2):77-89.
2002: Henriette Gourdeau; Philippe Genne; Salam Kadhim; Lucie Bibeau; Olivier Duchamp; France Ouellet; Jean-Marc deMuys; David Y Bouffard; Giorgio Attardo
Antitumor activity of troxacitabine (Troxatyl) against anthracycline-resistant human xenografts.
Cancer chemotherapy and pharmacology 2002;50(6):490-6.
2002: Lorraine Leblond; Giorgio Attardo; Bettina Hamelin; David Y Bouffard; Nghe Nguyen-Ba; Henriette Gourdeau
BCH-1868 [(-)-2-R-dihydroxyphosphinoyl-5-(S)-(guanin-9'-yl-methyl) tetrahydrofuran]: a cyclic nucleoside phosphonate with antitumor activity.
Molecular cancer therapeutics 2002;1(9):737-46.
2002: Henriette Gourdeau; Marsha Speevak; Lucie Jetté; Mario Chevrette
Whole-cell and microcell fusion for the identification of natural regulators of telomerase.
Methods in molecular biology (Clifton, N.J.) 2002;191():173-95.
2001: Y Tong; Q Yang; CA Vater; LK Venkatesh; Dominique Custeau; T Chittenden; Govindaswamy Chinnadurai; Henriette Gourdeau
The pro-apoptotic protein, Bik, exhibits potent antitumor activity that is dependent on its BH3 domain.
Molecular cancer therapeutics 2001;1(2):95-102.
2001: Henriette Gourdeau; Marilyn Lesley Clarke; France Ouellet; Delores Mowles; M Selner; Annie Richard; N Lee; John R Mackey; James D Young; Jacques Jolivet; R G Lafrenière; Carol E Cass
Mechanisms of uptake and resistance to troxacitabine, a novel deoxycytidine nucleoside analogue, in human leukemic and solid tumor cell lines.
Cancer research 2001;61(19):7217-24.
2001: Henriette Gourdeau; Lucie Bibeau; France Ouellet; Dominique Custeau; L Bernier; Terry Bowlin
Comparative study of a novel nucleoside analogue (Troxatyl, troxacitabine, BCH-4556) and AraC against leukemic human tumor xenografts expressing high or low cytidine deaminase activity.
Cancer chemotherapy and pharmacology 2001;47(3):236-40.
1999: JM de Muys; Henriette Gourdeau; Nghe Nguyen-Ba; DL Taylor; Parvin Ahmed; TS Mansour; C Locas; N Richard; Mark A Wainberg; RF Rando
Anti-human immunodeficiency virus type 1 activity, intracellular metabolism, and pharmacokinetic evaluation of 2'-deoxy-3'-oxa-4'-thiocytidine.
Antimicrobial agents and chemotherapy 1999;43(8):1835-44.