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Naomi Ariel

Research Profile

Chemicals & Drugs

Physiology

Mutagenesis, Site-Directed

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Mutagenesis, Insertional

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Publications

TOP 3
Anat Zvi; Naomi Ariel; John Fulkerson; Jerald C Sadoff; Avigdor Shafferman
Whole genome identification of Mycobacterium tuberculosis vaccine candidates by comprehensive data mining and bioinformatic analyses.
Orit Gat; Haim Grosfeld; Naomi Ariel; Itzhak Inbar; Galia Zaide; Yehoshua Broder; Anat Zvi; Theodor Chitlaru; Zeev Altboum; Dana Stein; Sara Cohen; Avigdor Shafferman
Search for Bacillus anthracis potential vaccine candidates by a functional genomic-serologic screen.
Theodor Chitlaru; Orit Gat; Yael Gozlan; Naomi Ariel; Avigdor Shafferman
Differential proteomic analysis of the Bacillus anthracis secretome: distinct plasmid and chromosome CO2-dependent cross talk mechanisms modulate extracellular proteolytic activities.

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All Publications

2008: Anat Zvi; Naomi Ariel; John Fulkerson; Jerald C Sadoff; Avigdor Shafferman
Whole genome identification of Mycobacterium tuberculosis vaccine candidates by comprehensive data mining and bioinformatic analyses.
BMC medical genomics 2008;1():18.
2006: Orit Gat; Haim Grosfeld; Naomi Ariel; Itzhak Inbar; Galia Zaide; Yehoshua Broder; Anat Zvi; Theodor Chitlaru; Zeev Altboum; Dana Stein; Sara Cohen; Avigdor Shafferman
Search for Bacillus anthracis potential vaccine candidates by a functional genomic-serologic screen.
Infection and immunity 2006;74(7):3987-4001.
2006: Theodor Chitlaru; Orit Gat; Yael Gozlan; Naomi Ariel; Avigdor Shafferman
Differential proteomic analysis of the Bacillus anthracis secretome: distinct plasmid and chromosome CO2-dependent cross talk mechanisms modulate extracellular proteolytic activities.
Journal of bacteriology 2006;188(10):3551-71.
2005: Orit Gat; Itai Mendelson; Theodor Chitlaru; Naomi Ariel; Zeev Altboum; Haim Levy; Shay Weiss; Haim Grosfeld; Sara Cohen; Avigdor Shafferman
The solute-binding component of a putative Mn(II) ABC transporter (MntA) is a novel Bacillus anthracis virulence determinant.
Molecular microbiology 2005;58(2):533-51.
2005: Haim Levy; Morly Fisher; Naomi Ariel; Zeev Altboum; David Kobiler
Identification of strain specific markers in Bacillus anthracis by random amplification of polymorphic DNA.
FEMS microbiology letters 2005;244(1):199-205.
2004: Theodor Chitlaru; Naomi Ariel; Anat Zvi; Menahem Lion; Baruch Velan; Avigdor Shafferman; Eytan Elhanany
Identification of chromosomally encoded membranal polypeptides of Bacillus anthracis by a proteomic analysis: prevalence of proteins containing S-layer homology domains.
Proteomics 2004;4(3):677-91.
2004: Yehuda Flashner; Emanuelle Mamroud; Avital Tidhar; Raphael Ber; Moshe Aftalion; David Gur; Shirley Lazar; Anat Zvi; Tamar Bino; Naomi Ariel; Baruch Velan; Avigdor Shafferman; Sara Cohen
Generation of Yersinia pestis attenuated strains by signature-tagged mutagenesis in search of novel vaccine candidates.
Infection and immunity 2004;72(2):908-15.
2003: Naomi Ariel; Anat Zvi; K S Makarova; Theodor Chitlaru; Eytan Elhanany; Baruch Velan; Sara Cohen; Arthur M Friedlander; Avigdor Shafferman
Genome-based bioinformatic selection of chromosomal Bacillus anthracis putative vaccine candidates coupled with proteomic identification of surface-associated antigens.
Infection and immunity 2003;71(8):4563-79.
2003: Yehuda Flashner; Emanuelle Mamroud; Avital Tidhar; Raphael Ber; Moshe Aftalion; David Gur; Anat Zvi; Naomi Ariel; Baruch Velan; Avigdor Shafferman; Sara Cohen
Identification of genes involved in Yersinia pestis virulence by signature-tagged mutagenesis.
Advances in experimental medicine and biology 2003;529():31-3.
2002: Naomi Ariel; Anat Zvi; Haim Grosfeld; Orit Gat; Y Inbar; Baruch Velan; Sara Cohen; Avigdor Shafferman
Search for potential vaccine candidate open reading frames in the Bacillus anthracis virulence plasmid pXO1: in silico and in vitro screening.
Infection and immunity 2002;70(12):6817-27.
2002: Dov Barak; Dana Kaplan; Arie Ordentlich; Naomi Ariel; Baruch Velan; Avigdor Shafferman
The aromatic "trapping" of the catalytic histidine is essential for efficient catalysis in acetylcholinesterase.
Biochemistry 2002;41(26):8245-52.
2001: Dana Kaplan; Arie Ordentlich; Dov Barak; Naomi Ariel; Chanoch Kronman; Baruch Velan; Avigdor Shafferman
Does "butyrylization" of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase?
Biochemistry 2001;40(25):7433-45.
2000: G Kryger; Michal Harel; K Giles; Lilly Toker; Baruch Velan; A Lazar; Chanoch Kronman; Dov Barak; Naomi Ariel; Avigdor Shafferman; Israel Silman; Joel Sussman
Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 11):1385-94.
1999: Arie Ordentlich; Dov Barak; Chanoch Kronman; Hendrik P Benschop; L P A de Jong; Naomi Ariel; R Barak; Yoffi Segall; Baruch Velan; Avigdor Shafferman
Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers.
Biochemistry 1999;38(10):3055-66.
1998: Naomi Ariel; Arie Ordentlich; Dov Barak; Tamar Bino; Baruch Velan; Avigdor Shafferman
The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors.
The Biochemical journal 1998;335 ( Pt 1)():95-102.
1998: Itai Mendelson; Chanoch Kronman; Naomi Ariel; Avigdor Shafferman; Baruch Velan
Bovine acetylcholinesterase: cloning, expression and characterization.
The Biochemical journal 1998;334 ( Pt 1)():251-9.
1998: Arie Ordentlich; Dov Barak; Chanoch Kronman; Naomi Ariel; Yoffi Segall; Baruch Velan; Avigdor Shafferman
Functional characteristics of the oxyanion hole in human acetylcholinesterase.
The Journal of biological chemistry 1998;273(31):19509-17.
1997: Avigdor Shafferman; Arie Ordentlich; Dov Barak; D Stein; Naomi Ariel; Baruch Velan
Aging of somanyl-acetylcholinesterase adducts: facts and models.
The Biochemical journal 1997;324 ( Pt 3)():996-8.
1996: Baruch Velan; Dov Barak; Naomi Ariel; M Leitner; T Bino; Arie Ordentlich; Avigdor Shafferman
Structural modifications of the omega loop in human acetylcholinesterase.
FEBS letters 1996;395(1):22-8.
1996: Avigdor Shafferman; Arie Ordentlich; Dov Barak; D Stein; Naomi Ariel; Baruch Velan
Aging of phosphylated human acetylcholinesterase: catalytic processes mediated by aromatic and polar residues of the active centre.
The Biochemical journal 1996;318 ( Pt 3)():833-40.
1996: Arie Ordentlich; Dov Barak; Chanoch Kronman; Naomi Ariel; Yoffi Segall; Baruch Velan; Avigdor Shafferman
The architecture of human acetylcholinesterase active center probed by interactions with selected organophosphate inhibitors.
The Journal of biological chemistry 1996;271(20):11953-62.
1995: Dov Barak; Arie Ordentlich; A Bromberg; Chanoch Kronman; D Marcus; A Lazar; Naomi Ariel; Baruch Velan; Avigdor Shafferman
Allosteric modulation of acetylcholinesterase activity by peripheral ligands involves a conformational transition of the anionic subsite.
Biochemistry 1995;34(47):15444-52.
1995: Arie Ordentlich; Dov Barak; Chanoch Kronman; Naomi Ariel; Yoffi Segall; Baruch Velan; Avigdor Shafferman
Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase.
The Journal of biological chemistry 1995;270(5):2082-91.
1994: Avigdor Shafferman; Arie Ordentlich; Dov Barak; Chanoch Kronman; R Ber; T Bino; Naomi Ariel; R Osman; Baruch Velan
Electrostatic attraction by surface charge does not contribute to the catalytic efficiency of acetylcholinesterase.
The EMBO journal 1994;13(15):3448-55.
1994: Dov Barak; Chanoch Kronman; Arie Ordentlich; Naomi Ariel; A Bromberg; D Marcus; A Lazar; Baruch Velan; Avigdor Shafferman
Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core.
The Journal of biological chemistry 1994;269(9):6296-305.
1993: Yoffi Segall; D Waysbort; Dov Barak; Naomi Ariel; Bhupendra P Doctor; J Grunwald; Yacov Ashani
Direct observation and elucidation of the structures of aged and nonaged phosphorylated cholinesterases by 31P NMR spectroscopy.
Biochemistry 1993;32(49):13441-50.
1993: Arie Ordentlich; Chanoch Kronman; Dov Barak; D Stein; Naomi Ariel; D Marcus; Baruch Velan; Avigdor Shafferman
Engineering resistance to 'aging' of phosphylated human acetylcholinesterase. Role of hydrogen bond network in the active center.
FEBS letters 1993;334(2):215-20.
1993: Arie Ordentlich; Dov Barak; Chanoch Kronman; Y Flashner; M Leitner; Yoffi Segall; Naomi Ariel; S Cohen; Baruch Velan; Avigdor Shafferman
Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket.
The Journal of biological chemistry 1993;268(23):17083-95.
1992: Avigdor Shafferman; Baruch Velan; Arie Ordentlich; Chanoch Kronman; H Grosfeld; M Leitner; Y Flashner; S Cohen; Dov Barak; Naomi Ariel
Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center.
The EMBO journal 1992;11(10):3561-8.
1992: Avigdor Shafferman; Chanoch Kronman; Y Flashner; M Leitner; H Grosfeld; Arie Ordentlich; Y Gozes; S Cohen; Naomi Ariel; Dov Barak
Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding.
The Journal of biological chemistry 1992;267(25):17640-8.
1990: Naomi Ariel; S Lehrer; E Elhanaty; T Sabo; P Brodt; B Lachmi; D Katz; R Levin; H Grosfeld; Baruch Velan
Serologically defined linear epitopes in the E2 envelope glycoprotein of Semliki Forest virus.
Archives of virology 1990;113(1-2):99-106.
1988: Naomi Ariel; D Katz; E Alhanaty
Application of chemically synthetic peptides in clinical diagnosis of viruses: theoretical and practical considerations.
Advances in biotechnological processes 1988;10():81-96.
1987: A Lazar; S Reuveny; J Geva; D Marcus; L Silberstein; Naomi Ariel; N Epstein; Z Altbaum; J Sinai; A Mizrahi
Production of carcinoembryonic antigen from a human colon adenocarcinoma cell line. I. Large-scale cultivation of carcinoembryonic antigen-producing cells on cylindric cellulose-based microcarriers.
Developments in biological standardization 1987;66():423-8.
1987: N Epstein; R Zandani; I Inbar; Z Altbaum; A Lazar; S Reuveny; J Geva; D Marcus; A Mizrahi; Naomi Ariel
Production of carcinoembryonic antigen from a human colon adenocarcinoma cell line. II. Use of monoclonal antibodies to carcinoembryonic antigen for antigen purification and characterization.
Developments in biological standardization 1987;66():429-37.