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Manfred Grabner

Research Profile

Chemicals & Drugs

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Amino Acid Sequences

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TOP 3
Anamika Dayal; Clara Franzini-Armstrong; Vinayakumar Bhat; Manfred Grabner
Domain cooperativity in the β1a subunit is essential for dihydropyridine receptor voltage sensing in skeletal muscle.
Antonella Pirone; Johann Schredelseker; Petronel Tuluc; Elvira Gravino; Giuliana Fortunato; Bernhard E Flucher; Antonella Carsana; Francesco Salvatore; Manfred Grabner
Identification and functional characterization of malignant hyperthermia mutation T1354S in the outer pore of the Cavalpha1S-subunit.
Anamika Dayal; Johann Schredelseker; Clara Franzini-Armstrong; Manfred Grabner
Skeletal muscle excitation-contraction coupling is independent of a conserved heptad repeat motif in the C-terminus of the DHPRbeta(1a) subunit.

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All Publications

2013: Anamika Dayal; Clara Franzini-Armstrong; Vinayakumar Bhat; Manfred Grabner
Domain cooperativity in the β1a subunit is essential for dihydropyridine receptor voltage sensing in skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(18):7488-93.
2010: Antonella Pirone; Johann Schredelseker; Petronel Tuluc; Elvira Gravino; Giuliana Fortunato; Bernhard E Flucher; Antonella Carsana; Francesco Salvatore; Manfred Grabner
Identification and functional characterization of malignant hyperthermia mutation T1354S in the outer pore of the Cavalpha1S-subunit.
American journal of physiology. Cell physiology 2010;299(6):C1345-54.
2010: Anamika Dayal; Johann Schredelseker; Clara Franzini-Armstrong; Manfred Grabner
Skeletal muscle excitation-contraction coupling is independent of a conserved heptad repeat motif in the C-terminus of the DHPRbeta(1a) subunit.
Cell calcium 2010;47(6):500-6.
2010: Johann Schredelseker; Manisha Shrivastav; Anamika Dayal; Manfred Grabner
Non-Ca2+-conducting Ca2+ channels in fish skeletal muscle excitation-contraction coupling.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(12):5658-63.
2010: Manfred Grabner; Anamika Dayal
Crosstalk via the Sarcoplasmic Gap: The DHPR-RyR Interaction.
Current topics in membranes 2010;66C():115-38.
2009: Johann Schredelseker; Anamika Dayal; Thorsten Schwerte; Clara Franzini-Armstrong; Manfred Grabner
Proper restoration of excitation-contraction coupling in the dihydropyridine receptor beta1-null zebrafish relaxed is an exclusive function of the beta1a subunit.
The Journal of biological chemistry 2009;284(2):1242-51.
2005: Johann Schredelseker; Valentina Di Biase; Gerald Obermair; Edward Felder; Bernhard E Flucher; Clara Franzini-Armstrong; Manfred Grabner
The beta 1a subunit is essential for the assembly of dihydropyridine-receptor arrays in skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(47):17219-24.
2005: Ralph Peter Schuhmeier; Elodie GOUADON; Daniel Ursu; Nicole Kasielke; Bernhard E Flucher; Manfred Grabner; Werner Melzer
Functional interaction of CaV channel isoforms with ryanodine receptors studied in dysgenic myotubes.
Biophysical journal 2005;88(3):1765-77.
2005: Gerald Obermair; Gerlinde Kugler; Sabine Baumgartner; Petronel Tuluc; Manfred Grabner; Bernhard E Flucher
The Ca2+ channel alpha2delta-1 subunit determines Ca2+ current kinetics in skeletal muscle but not targeting of alpha1S or excitation-contraction coupling.
The Journal of biological chemistry 2005;280(3):2229-37.
2005: Bernhard E Flucher; Gerald Obermair; Petronel Tuluc; Johann Schredelseker; Georg Kern; Manfred Grabner
The role of auxiliary dihydropyridine receptor subunits in muscle.
Journal of muscle research and cell motility 2005;26(1):1-6.
2004: Hiroaki Takekura; Cecilia Paolini; Clara Franzini-Armstrong; Gerlinde Kugler; Manfred Grabner; Bernhard E Flucher
Differential contribution of skeletal and cardiac II-III loop sequences to the assembly of dihydropyridine-receptor arrays in skeletal muscle.
Molecular biology of the cell 2004;15(12):5408-19.
2004: Regina G Weiss; Kristen M S O'Connell; Bernhard E Flucher; Paul D Allen; Manfred Grabner; Robert T Dirksen
Functional analysis of the R1086H malignant hyperthermia mutation in the DHPR reveals an unexpected influence of the III-IV loop on skeletal muscle EC coupling.
American journal of physiology. Cell physiology 2004;287(4):C1094-102.
2004: Gerlinde Kugler; Manfred Grabner; Josef Platzer; Jörg Striessnig; Bernhard E Flucher
The monoclonal antibody mAB 1A binds to the excitation--contraction coupling domain in the II-III loop of the skeletal muscle calcium channel alpha(1S) subunit.
Archives of biochemistry and biophysics 2004;427(1):91-100.
2004: Gerlinde Kugler; Regina G Weiss; Bernhard E Flucher; Manfred Grabner
Structural requirements of the dihydropyridine receptor alpha1S II-III loop for skeletal-type excitation-contraction coupling.
The Journal of biological chemistry 2004;279(6):4721-8.
2003: alexandra koschak; Daniel Reimer; Doris Walter; Jean-Charles Hoda; Thomas Heinzle; Manfred Grabner; Jörg Striessnig
Cav1.4alpha1 subunits can form slowly inactivating dihydropyridine-sensitive L-type Ca2+ channels lacking Ca2+-dependent inactivation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(14):6041-9.
2003: Nicole Kasielke; Gerald Obermair; Gerlinde Kugler; Manfred Grabner; Bernhard E Flucher
Cardiac-type EC-coupling in dysgenic myotubes restored with Ca2+ channel subunit isoforms alpha1C and alpha1D does not correlate with current density.
Biophysical journal 2003;84(6):3816-28.
2002: Bernhard E Flucher; Regina G Weiss; Manfred Grabner
Cooperation of two-domain Ca(2+) channel fragments in triad targeting and restoration of excitation- contraction coupling in skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):10167-72.
2002: Edwin Wappl; alexandra koschak; Michael Poteser; martina Sinnegger-Brauns; Doris Walter; Andreas Eberhart; Klaus Groschner; Hartmut Glossmann; Richard L Kraus; Manfred Grabner; Jörg Striessnig
Functional consequences of P/Q-type Ca2+ channel Cav2.1 missense mutations associated with episodic ataxia type 2 and progressive ataxia.
The Journal of biological chemistry 2002;277(9):6960-6.
2001: Christina M Wilkens; Manfred Grabner; Kurt G Beam
Potentiation of the cardiac L-type Ca(2+) channel (alpha(1C)) by dihydropyridine agonist and strong depolarization occur via distinct mechanisms.
The Journal of general physiology 2001;118(5):495-508.
2001: alexandra koschak; Daniel Reimer; Irene G Huber; Manfred Grabner; Hartmut Glossmann; J Engel; Jörg Striessnig
alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltages.
The Journal of biological chemistry 2001;276(25):22100-6.
2001: Christina M Wilkens; Nicole Kasielke; Bernhard E Flucher; Kurt G Beam; Manfred Grabner
Excitation-contraction coupling is unaffected by drastic alteration of the sequence surrounding residues L720-L764 of the alpha 1S II-III loop.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5892-7.
2001: Nancy M Lorenzon; Manfred Grabner; N Suda; Kurt G Beam
Structure and targeting of RyR1: implications from fusion of green fluorescent protein at the amino-terminal.
Archives of biochemistry and biophysics 2001;388(1):13-7.
2000: Bernhard E Flucher; Nicole Kasielke; Manfred Grabner
The triad targeting signal of the skeletal muscle calcium channel is localized in the COOH terminus of the alpha(1S) subunit.
The Journal of cell biology 2000;151(2):467-78.
2000: Bernhard E Flucher; Nicole Kasielke; U Gerster; Birgit Neuhuber; Manfred Grabner
Insertion of the full-length calcium channel alpha(1S) subunit into triads of skeletal muscle in vitro.
FEBS letters 2000;474(1):93-8.
1999: Manfred Grabner; Robert T Dirksen; N Suda; Kurt G Beam
The II-III loop of the skeletal muscle dihydropyridine receptor is responsible for the Bi-directional coupling with the ryanodine receptor.
The Journal of biological chemistry 1999;274(31):21913-9.
1998: Richard L Kraus; Steffen Hering; Manfred Grabner; D Ostler; Jörg Striessnig
Molecular mechanism of diltiazem interaction with L-type Ca2+ channels.
The Journal of biological chemistry 1998;273(42):27205-12.
1998: J Mitterdorfer; Manfred Grabner; Richard L Kraus; Steffen Hering; H Prinz; Hartmut Glossmann; Jörg Striessnig
Molecular basis of drug interaction with L-type Ca2+ channels.
Journal of bioenergetics and biomembranes 1998;30(4):319-34.
1998: Jörg Striessnig; Manfred Grabner; J Mitterdorfer; Steffen Hering; martina Sinnegger-Brauns; Hartmut Glossmann
Structural basis of drug binding to L Ca2+ channels.
Trends in pharmacological sciences 1998;19(3):108-15.
1998: Manfred Grabner; Robert T Dirksen; Kurt G Beam
Tagging with green fluorescent protein reveals a distinct subcellular distribution of L-type and non-L-type Ca2+ channels expressed in dysgenic myotubes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(4):1903-8.
1997: martina Sinnegger-Brauns; Z Wang; Manfred Grabner; Steffen Hering; Jörg Striessnig; Hartmut Glossmann; J Mitterdorfer
Nine L-type amino acid residues confer full 1,4-dihydropyridine sensitivity to the neuronal calcium channel alpha1A subunit. Role of L-type Met1188.
The Journal of biological chemistry 1997;272(44):27686-93.
1996: J Mitterdorfer; Z Wang; martina Sinnegger-Brauns; Steffen Hering; Jörg Striessnig; Manfred Grabner; Hartmut Glossmann
Two amino acid residues in the IIIS5 segment of L-type calcium channels differentially contribute to 1,4-dihydropyridine sensitivity.
The Journal of biological chemistry 1996;271(48):30330-5.
1996: M Pichler; Z Wang; C Grabner-Weiss; D Reimer; Steffen Hering; Manfred Grabner; Hartmut Glossmann; Jörg Striessnig
Block of P/Q-type calcium channels by therapeutic concentrations of aminoglycoside antibiotics.
Biochemistry 1996;35(46):14659-64.
1996: Steffen Hering; S Aczél; Manfred Grabner; F Döring; Stanislav Berjukow; J Mitterdorfer; martina Sinnegger-Brauns; Jörg Striessnig; Vadim Degtiar; Z Wang; Hartmut Glossmann
Transfer of high sensitivity for benzothiazepines from L-type to class A (BI) calcium channels.
The Journal of biological chemistry 1996;271(40):24471-5.
1996: Richard L Kraus; B Reichl; S D Kimball; Manfred Grabner; B J Murphy; W A Catterall; Jörg Striessnig
Identification of benz(othi)azepine-binding regions within L-type calcium channel alpha1 subunits.
The Journal of biological chemistry 1996;271(33):20113-8.
1996: J Mitterdorfer; M Froschmayr; Manfred Grabner; Fabian F Moebius; Hartmut Glossmann; Jörg Striessnig
Identification of PK-A phosphorylation sites in the carboxyl terminus of L-type calcium channel alpha 1 subunits.
Biochemistry 1996;35(29):9400-6.
1996: Stanislav Berjukow; F Döring; M Froschmayr; Manfred Grabner; Hartmut Glossmann; Steffen Hering
Endogenous calcium channels in human embryonic kidney (HEK293) cells.
British journal of pharmacology 1996;118(3):748-54.
1996: F Döring; Vadim Degtiar; Manfred Grabner; Jörg Striessnig; Steffen Hering; H Glossman
Transfer of L-type calcium channel IVS6 segment increases phenylalkylamine sensitivity of alpha1A.
The Journal of biological chemistry 1996;271(20):11745-9.
1996: Manfred Grabner; Z Wang; Steffen Hering; Jörg Striessnig; Hartmut Glossmann
Transfer of 1,4-dihydropyridine sensitivity from L-type to class A (BI) calcium channels.
Neuron 1996;16(1):207-18.
1995: J Mitterdorfer; martina Sinnegger-Brauns; Manfred Grabner; Jörg Striessnig; Hartmut Glossmann
Coordination of Ca2+ by the pore region glutamates is essential for high-affinity dihydropyridine binding to the cardiac Ca2+ channel alpha 1 subunit.
Biochemistry 1995;34(29):9350-5.
1995: Z Wang; Manfred Grabner; Stanislav Berjukow; Alex Savchenko; Hartmut Glossmann; Steffen Hering
Chimeric L-type Ca2+ channels expressed in Xenopus laevis oocytes reveal role of repeats III and IV in activation gating.
The Journal of physiology 1995;486 ( Pt 1)():131-7.
1995: Markus Hanner; Fabian F Moebius; F Weber; Manfred Grabner; Jörg Striessnig; Hartmut Glossmann
Phenylalkylamine Ca2+ antagonist binding protein. Molecular cloning, tissue distribution, and heterologous expression.
The Journal of biological chemistry 1995;270(13):7551-7.
1994: J Mitterdorfer; M Froschmayr; Manfred Grabner; Jörg Striessnig; Hartmut Glossmann
Calcium channels: the beta-subunit increases the affinity of dihydropyridine and Ca2+ binding sites of the alpha 1-subunit.
FEBS letters 1994;352(2):141-5.
1994: Manfred Grabner; Z Wang; J Mitterdorfer; F Rosenthal; P Charnet; Alex Savchenko; Steffen Hering; D Ren; Linda Hall; Hartmut Glossmann
Cloning and functional expression of a neuronal calcium channel beta subunit from house fly (Musca domestica).
The Journal of biological chemistry 1994;269(38):23668-74.
1994: Manfred Grabner; A Bachmann; F Rosenthal; Jörg Striessnig; C Schultz; D Tautz; Hartmut Glossmann
Insect calcium channels. Molecular cloning of an alpha 1-subunit from housefly (Musca domestica) muscle.
FEBS letters 1994;339(1-2):189-94.
1991: Manfred Grabner; K Friedrich; Hans-Günther Knaus; Jörg Striessnig; F Scheffauer; R Staudinger; Walter J Koch; A Schwartz; Hartmut Glossmann
Calcium channels from Cyprinus carpio skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):727-31.
1988: Jörg Striessnig; E Meusburger; Manfred Grabner; Hans-Günther Knaus; Hartmut Glossmann; J Kaiser; B Schölkens; R Becker; W Linz; R Henning
Evidence for a distinct Ca2+ antagonist receptor for the novel benzothiazinone compound HOE 166.
Naunyn-Schmiedeberg's archives of pharmacology 1988;337(3):331-40.
1987: Jörg Striessnig; Hans-Günther Knaus; Manfred Grabner; K Moosburger; W Seitz; H Lietz; Hartmut Glossmann
Photoaffinity labelling of the phenylalkylamine receptor of the skeletal muscle transverse-tubule calcium channel.
FEBS letters 1987;212(2):247-53.