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Valentin Grabovsky

Research Profile

Physiology

Chemicals & Drugs

Anatomy

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Publications

TOP 3
Raizy Gruda; Chamutal Gur; Saar Mizrahi; Hagit Achdout; Memet Aker; Ronen Alon; Yotam Bar-On; Alice C N Brown; Daniel M Davis; Sara W Feigelson; Valentin Grabovsky; Ofer Mandelboim
Loss of kindlin-3 alters the threshold for NK cell activation in human leukocyte adhesion deficiency-III.
Sara W Feigelson; Valentin Grabovsky; Eugenia Klein; Eugenia Manevich-Mendelson; Ronit Pasvolsky; Vera Shinder; Ziv Shulman; Memet Aker; Amos Etzioni; Ronen Alon
Kindlin-3 is required for the stabilization of TCR-stimulated LFA-1:ICAM-1 bonds critical for lymphocyte arrest and spreading on dendritic cells.
Eugenia Manevich-Mendelson; Valentin Grabovsky; Sara W Feigelson; Guy Cinamon; Yael Gore; Gera Goverse; Susan J Monkley; Raanan Margalit; Doron Melamed; Reina E Mebius; David R Critchley; Idit Shachar; Ronen Alon
Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen.

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All Publications

2012: Raizy Gruda; Chamutal Gur; Saar Mizrahi; Hagit Achdout; Memet Aker; Ronen Alon; Yotam Bar-On; Alice C N Brown; Daniel M Davis; Sara W Feigelson; Valentin Grabovsky; Ofer Mandelboim
Loss of kindlin-3 alters the threshold for NK cell activation in human leukocyte adhesion deficiency-III.
Blood 2012;120(19):3915-24.
2011: Sara W Feigelson; Valentin Grabovsky; Eugenia Klein; Eugenia Manevich-Mendelson; Ronit Pasvolsky; Vera Shinder; Ziv Shulman; Memet Aker; Amos Etzioni; Ronen Alon
Kindlin-3 is required for the stabilization of TCR-stimulated LFA-1:ICAM-1 bonds critical for lymphocyte arrest and spreading on dendritic cells.
Blood 2011;117(26):7042-52.
2010: Eugenia Manevich-Mendelson; Valentin Grabovsky; Sara W Feigelson; Guy Cinamon; Yael Gore; Gera Goverse; Susan J Monkley; Raanan Margalit; Doron Melamed; Reina E Mebius; David R Critchley; Idit Shachar; Ronen Alon
Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen.
Blood 2010;116(26):5907-18.
2010: Sara W Feigelson; Ronit Pasvolsky; Saso Cemerski; Ziv Shulman; Valentin Grabovsky; Tal Ilani; Adi Sagiv; Fabrice Lemaitre; Carlo Laudanna; Andrey S Shaw; Ronen Alon
Occupancy of lymphocyte LFA-1 by surface-immobilized ICAM-1 is critical for TCR- but not for chemokine-triggered LFA-1 conversion to an open headpiece high-affinity state.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(12):7394-404.
2009: Eugenia Manevich-Mendelson; Sara W Feigelson; Ronit Pasvolsky; Memet Aker; Valentin Grabovsky; Ziv Shulman; Sara Sebnem Kilic; Maria Alessandra Rosenthal-Allieri; Shifra Ben-Dor; Adi Mory; Alain Bernard; Markus Moser; Amos Etzioni; Ronen Alon
Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions.
Blood 2009;114(11):2344-53.
2009: Raffaella Molteni; Carolina Lage Crespo; Sara Feigelson; Christian Moser; Monica Fabbri; Valentin Grabovsky; Fritz Krombach; Carlo Laudanna; Ronen Alon; Ruggero Pardi
Beta-arrestin 2 is required for the induction and strengthening of integrin-mediated leukocyte adhesion during CXCR2-driven extravasation.
Blood 2009;114(5):1073-82.
2009: Tanja Nicole Hartmann; Valentin Grabovsky; Wei Wang; Petra Desch; Gabriele Rubenzer; Stefan Wollner; Inbal Binsky; Alexandra Vallon-Eberhard; Anita Sapoznikov; Meike Burger; Idit Shachar; Michal Haran; Marek Honczarenko; richard greil; Ronen Alon
Circulating B-cell chronic lymphocytic leukemia cells display impaired migration to lymph nodes and bone marrow.
Cancer research 2009;69(7):3121-30.
2009: Ziv Shulman; Vera Shinder; Eugenia Klein; Valentin Grabovsky; Orna Yeger; Erez Geron; Alessio Montresor; Matteo Bolomini-Vittori; Sara W Feigelson; Tomas Kirchhausen; Carlo Laudanna; Guy Shakhar; Ronen Alon
Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin.
Immunity 2009;30(3):384-96.
2008: Liat Flaishon; Gili Hart; Einat Zelman; Christine Moussion; Valentin Grabovsky; Guy Lapidot Tal; Sara W Feigelson; Raanan Margalit; Alon Harmelin; Tamar Avin-Wittenberg; David Shoseyov; Ronen Alon; Jean-Philippe Girard; Idit Shachar
Anti-inflammatory effects of an inflammatory chemokine: CCL2 inhibits lymphocyte homing by modulation of CCL21-triggered integrin-mediated adhesions.
Blood 2008;112(13):5016-25.
2008: Tanja Nicole Hartmann; Valentin Grabovsky; Ronit Pasvolsky; Ziv Shulman; Eike C Buss; Asaf Spiegel; Arnon Nagler; Tsvee Lapidot; Marcus Thelen; Ronen Alon
A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells.
Journal of leukocyte biology 2008;84(4):1130-40.
2008: Ronit Pasvolsky; Valentin Grabovsky; Cinzia Giagulli; Ziv Shulman; Revital Shamri; Sara W Feigelson; Carlo Laudanna; Ronen Alon
RhoA is involved in LFA-1 extension triggered by CXCL12 but not in a novel outside-in LFA-1 activation facilitated by CXCL9.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):2815-23.
2007: Eilon Woolf; Irina L Grigorova; Adi Sagiv; Valentin Grabovsky; Sara W Feigelson; Ziv Shulman; Tanja Hartmann; Michael Sixt; Jason G Cyster; Ronen Alon
Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces.
Nature immunology 2007;8(10):1076-85.
2007: Eugenia Manevich; Valentin Grabovsky; Sara W Feigelson; Ronen Alon
Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1.
The Journal of biological chemistry 2007;282(35):25338-48.
2007: Oren Dwir; Valentin Grabovsky; Ronit Pasvolsky; Eugenia Manevich; Revital Shamri; Paul Gutwein; Sara W Feigelson; Peter Altevogt; Ronen Alon
Membranal cholesterol is not required for L-selectin adhesiveness in primary lymphocytes but controls a chemokine-induced destabilization of L-selectin rolling adhesions.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):1030-8.
2007: Ronit Pasvolsky; Sara W Feigelson; Sara Sebnem Kilic; Amos J Simon; Guy Tal-Lapidot; Valentin Grabovsky; Jill R Crittenden; Ninette Amariglio; Michal Safran; Ann M Graybiel; Gideon Rechavi; Shifra Ben-Dor; Amos Etzioni; Ronen Alon
A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets.
The Journal of experimental medicine 2007;204(7):1571-82.
2006: Ziv Shulman; Ronit Pasvolsky; Eilon Woolf; Valentin Grabovsky; Sara W Feigelson; Neta Erez; Yoshinori Fukui; Ronen Alon
DOCK2 regulates chemokine-triggered lateral lymphocyte motility but not transendothelial migration.
Blood 2006;108(7):2150-8.
2006: Michal Dagan-Berger; Rotem Feniger-Barish; Shani Avniel; Hanna Wald; Eithan Galun; Valentin Grabovsky; Ronen Alon; Arnon Nagler; Adit Ben-Baruch; Amnon Peled
Role of CXCR3 carboxyl terminus and third intracellular loop in receptor-mediated migration, adhesion and internalization in response to CXCL11.
Blood 2006;107(10):3821-31.
2005: Ronen Alon; Sara W Feigelson; Eugenia Manevich; David M Rose; Julia Schmitz; Darryl R Overby; Eitan Winter; Valentin Grabovsky; Vera Shinder; Benjamin D Matthews; Maya Sokolovsky-Eisenberg; Donald Ingber; Martin Benoit; Mark H Ginsberg
Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain.
The Journal of cell biology 2005;171(6):1073-84.
2005: Revital Shamri; Valentin Grabovsky; Jean-Marc Gauguet; Sara W Feigelson; Eugenia Manevich; Waldemar Kolanus; Martyn K Robinson; Donald E Staunton; Ulrich H von Andrian; Ronen Alon
Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines.
Nature immunology 2005;6(5):497-506.
2004: Suzanna Franitza; Valentin Grabovsky; Ori Wald; Ido D Weiss; Katia Beider; Michal Dagan; Merav Darash-Yahana; Arnon Nagler; Stefan Brocke; Eithan Galun; Ronen Alon; Amnon Peled
Differential usage of VLA-4 and CXCR4 by CD3+CD56+ NKT cells and CD56+CD16+ NK cells regulates their interaction with endothelial cells.
European journal of immunology 2004;34(5):1333-41.
2004: Ilya Sotnikov; Rami Hershkoviz; Valentin Grabovsky; Neta Ilan; Liora Cahalon; Israel Vlodavsky; Ronen Alon; Ofer Lider
Enzymatically quiescent heparanase augments T cell interactions with VCAM-1 and extracellular matrix components under versatile dynamic contexts.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(9):5185-93.
2004: Tatsuo Kinashi; Memet Aker; Maya Sokolovsky-Eisenberg; Valentin Grabovsky; Chisato Tanaka; Revital Shamri; Sara W Feigelson; Amos Etzioni; Ronen Alon
LAD-III, a leukocyte adhesion deficiency syndrome associated with defective Rap1 activation and impaired stabilization of integrin bonds.
Blood 2004;103(3):1033-6.
2004: Oren Dwir; Valentin Grabovsky; Ronen Alon
Selectin avidity modulation by chemokines at subsecond endothelial contacts: a novel regulatory level of leukocyte trafficking.
Ernst Schering Research Foundation workshop 2004;(44):109-35.
2003: Sara W Feigelson; Valentin Grabovsky; Revital Shamri; Shoshana Levy; Ronen Alon
The CD81 tetraspanin facilitates instantaneous leukocyte VLA-4 adhesion strengthening to vascular cell adhesion molecule 1 (VCAM-1) under shear flow.
The Journal of biological chemistry 2003;278(51):51203-12.
2003: Ronen Alon; Valentin Grabovsky; Sara W Feigelson
Chemokine induction of integrin adhesiveness on rolling and arrested leukocytes local signaling events or global stepwise activation?
Microcirculation (New York, N.Y. : 1994) 2003;10(3-4):297-311.
2003: Ronen Alon; Memet Aker; Sara W Feigelson; Maya Sokolovsky-Eisenberg; Donald E Staunton; Guy Cinamon; Valentin Grabovsky; Revital Shamri; Amos Etzioni
A novel genetic leukocyte adhesion deficiency in subsecond triggering of integrin avidity by endothelial chemokines results in impaired leukocyte arrest on vascular endothelium under shear flow.
Blood 2003;101(11):4437-45.
2002: Revital Shamri; Valentin Grabovsky; Sara W Feigelson; Oren Dwir; Yvette van Kooyk; Ronen Alon
Chemokine stimulation of lymphocyte alpha 4 integrin avidity but not of leukocyte function-associated antigen-1 avidity to endothelial ligands under shear flow requires cholesterol membrane rafts.
The Journal of biological chemistry 2002;277(42):40027-35.
2002: Valentin Grabovsky; Oren Dwir; Ronen Alon
Endothelial chemokines destabilize L-selectin-mediated lymphocyte rolling without inducing selectin shedding.
The Journal of biological chemistry 2002;277(23):20640-50.
2002: Amnon Peled; Izhar Hardan; Luba Trakhtenbrot; Eyal Gur; Michal Magid; Merav Darash-Yahana; Ninette Cohen; Valentin Grabovsky; Suzanna Franitza; Orit Kollet; Ofer Lider; Ronen Alon; Gideon Rechavi; Tsvee Lapidot
Immature leukemic CD34+CXCR4+ cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1.
Stem cells (Dayton, Ohio) 2002;20(3):259-66.
2001: Shulamit B Wallach-Dayan; Valentin Grabovsky; Jurgen Moll; Jonathan Sleeman; Peter Herrlich; Ronen Alon; David Naor
CD44-dependent lymphoma cell dissemination: a cell surface CD44 variant, rather than standard CD44, supports in vitro lymphoma cell rolling on hyaluronic acid substrate and its in vivo accumulation in the peripheral lymph nodes.
Journal of cell science 2001;114(Pt 19):3463-77.
2001: David M Rose; Valentin Grabovsky; Ronen Alon; Mark H Ginsberg
The affinity of integrin alpha(4)beta(1) governs lymphocyte migration.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2824-30.
2001: Guy Cinamon; Valentin Grabovsky; Eitan Winter; Suzanna Franitza; Sara W Feigelson; Revital Shamri; Oren Dwir; Ronen Alon
Novel chemokine functions in lymphocyte migration through vascular endothelium under shear flow.
Journal of leukocyte biology 2001;69(6):860-6.
2001: Sara W Feigelson; Valentin Grabovsky; Eitan Winter; L L Chen; R Blake Pepinsky; T Yednock; D Yablonski; Roy R Lobb; Ronen Alon
The Src kinase p56(lck) up-regulates VLA-4 integrin affinity. Implications for rapid spontaneous and chemokine-triggered T cell adhesion to VCAM-1 and fibronectin.
The Journal of biological chemistry 2001;276(17):13891-901.
2001: Anat Faber-Elmann; Valentin Grabovsky; Molly Dayan; Michael Sela; Ronen Alon; Edna Mozes
An altered peptide ligand inhibits the activities of matrix metalloproteinase-9 and phospholipase C, and inhibits T cell interactions with VCAM-1 induced in vivo by a myasthenogenic T cell epitope.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(1):187-194.
2000: Anat Faber-Elmann; Valentin Grabovsky; Molly Dayan; Michael Sela; Ronen Alon; Edna Mozes
Cytokine profile and T cell adhesiveness to endothelial selectins: in vivo induction by a myasthenogenic T cell epitope and immunomodulation by a dual altered peptide ligand.
International immunology 2000;12(12):1651-8.
2000: Teunis B H Geijtenbeek; Daniëlle J E B Krooshoop; DA Bleijs; Sandra J van Vliet; Gerard van Duijnhoven; Valentin Grabovsky; Ronen Alon; Carl G Figdor; Yvette van Kooyk
DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking.
Nature immunology 2000;1(4):353-7.
2000: Valentin Grabovsky; Sara W Feigelson; C Chen; DA Bleijs; Amnon Peled; Guy Cinamon; Françoise Baleux; Fernando Arenzana-Seisdedos; Tsvee Lapidot; Roy R Lobb; Ronen Alon
Subsecond induction of alpha4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions.
The Journal of experimental medicine 2000;192(4):495-506.
2000: Alex Sigal; DA Bleijs; Valentin Grabovsky; Sandra J van Vliet; Oren Dwir; Carl G Figdor; Yvette van Kooyk; Ronen Alon
The LFA-1 integrin supports rolling adhesions on ICAM-1 under physiological shear flow in a permissive cellular environment.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):442-52.
2000: Amnon Peled; Orit Kollet; Tanya Ponomaryov; Isabelle Petit; Suzanna Franitza; Valentin Grabovsky; M M Slav; Arnon Nagler; Ofer Lider; Ronen Alon; Dov Zipori; Tsvee Lapidot
The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice.
Blood 2000;95(11):3289-96.
1999: Amnon Peled; Valentin Grabovsky; Liliana Habler; Judith Sandbank; Fernando Arenzana-Seisdedos; Isabelle Petit; Herzl Ben-Hur; Tsvee Lapidot; Ronen Alon
The chemokine SDF-1 stimulates integrin-mediated arrest of CD34(+) cells on vascular endothelium under shear flow.
The Journal of clinical investigation 1999;104(9):1199-211.
1999: C Chen; J L Mobley; Oren Dwir; F Shimron; Valentin Grabovsky; Roy R Lobb; Y Shimizu; Ronen Alon
High affinity very late antigen-4 subsets expressed on T cells are mandatory for spontaneous adhesion strengthening but not for rolling on VCAM-1 in shear flow.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):1084-95.