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Dale Grabowski

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Susan A J Vaziri; Dale R Grabowski; Jason Hill; Lisa R Rybicki; Robert Burk; Ronald M Bukowski; Mahrukh K Ganapathi; Ram Ganapathi
Inhibition of proteasome activity by bortezomib in renal cancer cells is p53 dependent and VHL independent.
Adrian G Grozav; Kenichi Chikamori; Toshiyuki Kozuki; Dale R Grabowski; Ronald M Bukowski; Belinda Willard; Michael Kinter; Anni H Andersen; Ram Ganapathi; Mahrukh K Ganapathi
Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity.
Kenichi Chikamori; Jason E Hill; Dale R Grabowski; E Zarkhin; A G Grozav; Susan A J Vaziri; J Wang; Andrei V Gudkov; Lisa R Rybicki; Ronald M Bukowski; A Yen; M Tanimoto; Mahrukh K Ganapathi; Ram Ganapathi
Downregulation of topoisomerase IIbeta in myeloid leukemia cell lines leads to activation of apoptosis following all-trans retinoic acid-induced differentiation/growth arrest.

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All Publications

2009: Susan A J Vaziri; Dale R Grabowski; Jason Hill; Lisa R Rybicki; Robert Burk; Ronald M Bukowski; Mahrukh K Ganapathi; Ram Ganapathi
Inhibition of proteasome activity by bortezomib in renal cancer cells is p53 dependent and VHL independent.
Anticancer research 2009;29(8):2961-9.
2009: Adrian G Grozav; Kenichi Chikamori; Toshiyuki Kozuki; Dale R Grabowski; Ronald M Bukowski; Belinda Willard; Michael Kinter; Anni H Andersen; Ram Ganapathi; Mahrukh K Ganapathi
Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity.
Nucleic acids research 2009;37(2):382-92.
2006: Kenichi Chikamori; Jason E Hill; Dale R Grabowski; E Zarkhin; A G Grozav; Susan A J Vaziri; J Wang; Andrei V Gudkov; Lisa R Rybicki; Ronald M Bukowski; A Yen; M Tanimoto; Mahrukh K Ganapathi; Ram Ganapathi
Downregulation of topoisomerase IIbeta in myeloid leukemia cell lines leads to activation of apoptosis following all-trans retinoic acid-induced differentiation/growth arrest.
Leukemia 2006;20(10):1809-18.
2006: Nagio Takigawa; Susan A J Vaziri; Dale R Grabowski; Kenichi Chikamori; Lisa R Rybicki; Ronald M Bukowski; Mahrukh K Ganapathi; Ram Ganapathi; Tarek Mekhail
Proteasome inhibition with bortezomib enhances activity of topoisomerase I-targeting drugs by NF-kappaB-independent mechanisms.
Anticancer research 2006;26(3A):1869-76.
2005: Susan A J Vaziri; Jason Hill; Kenichi Chikamori; Dale R Grabowski; Nagio Takigawa; Mamta Chawla-Sarkar; Lisa R Rybicki; Andrei V Gudkov; Tarek Mekhail; Ronald M Bukowski; Mahrukh K Ganapathi; Ram Ganapathi
Sensitization of DNA damage-induced apoptosis by the proteasome inhibitor PS-341 is p53 dependent and involves target proteins 14-3-3sigma and survivin.
Molecular cancer therapeutics 2005;4(12):1880-90.
2003: Denise Uyar; Nagio Takigawa; Tarek Mekhail; Dale R Grabowski; Maurie Markman; Francis Lee; Renzo Canetta; Ron Peck; Ronald Bukowski; Ram Ganapathi
Apoptotic pathways of epothilone BMS 310705.
Gynecologic oncology 2003;91(1):173-8.
2003: Susan A J Vaziri; Dale R Grabowski; Masahiro Tabata; Katherine A Holmes; Joseph Sterk; Nagio Takigawa; Ronald M Bukowski; Mahrukh K Ganapathi; Ram Ganapathi
c-IAP1 is overexpressed in HL-60 cells selected for doxorubicin resistance: effects on etoposide-induced apoptosis.
Anticancer research 2003;23(5A):3657-61.
2003: Kenichi Chikamori; Dale R Grabowski; Michael Kinter; Belinda B Willard; Satya Yadav; Ruedi Aebersold; Ronald M Bukowski; Ian D Hickson; Anni H Andersen; Ram Ganapathi; Mahrukh K Ganapathi
Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity.
The Journal of biological chemistry 2003;278(15):12696-702.
2002: Ram Ganapathi; Susan A J Vaziri; Masahiro Tabata; Nagio Takigawa; Dale R Grabowski; Ronald M Bukowski; Mahrukh K Ganapathi
Inhibition of NF-kappaB and proteasome activity in tumors: can we improve the therapeutic potential of topoisomerase I and topoisomerase II poisons.
Current pharmaceutical design 2002;8(22):1945-58.
2001: KC Huang; Hanlin Gao; Edith F Yamasaki; Dale R Grabowski; S Liu; Linus L Shen; Kenneth K Chan; Ram Ganapathi; Robert M Snapka
Topoisomerase II poisoning by ICRF-193.
The Journal of biological chemistry 2001;276(48):44488-94.
2001: Masahiro Tabata; R Tabata; Dale R Grabowski; Ronald M Bukowski; Mahrukh K Ganapathi; Ram Ganapathi
Roles of NF-kappaB and 26 S proteasome in apoptotic cell death induced by topoisomerase I and II poisons in human nonsmall cell lung carcinoma.
The Journal of biological chemistry 2001;276(11):8029-36.
2001: Robert M Snapka; Hanlin Gao; Dale R Grabowski; D Brill; Kenneth K Chan; Lei Li; Gloria C Li; Ram Ganapathi
Cytotoxic mechanism of XK469: resistance of topoisomerase IIbeta knockout cells and inhibition of topoisomerase I.
Biochemical and biophysical research communications 2001;280(4):1155-60.
2001: M Aoyama; Dale R Grabowski; Katherine A Holmes; LA Rybicki; Ronald M Bukowski; Mahrukh K Ganapathi; Ram Ganapathi
Cell cycle phase specificity in the potentiation of etoposide-induced DNA damage and apoptosis by KN-62, an inhibitor of calcium-calmodulin-dependent enzymes.
Biochemical pharmacology 2001;61(1):49-54.
2001: Thomas C Rowe; Dale R Grabowski; Ram Ganapathi
Isolation of covalent enzyme-DNA complexes.
Methods in molecular biology (Clifton, N.J.) 2001;95():129-35.
1999: Dale R Grabowski; Katherine A Holmes; M Aoyama; Y Ye; LA Rybicki; Ronald M Bukowski; Mahrukh K Ganapathi; Ian D Hickson; Ram Ganapathi
Altered drug interaction and regulation of topoisomerase IIbeta: potential mechanisms governing sensitivity of HL-60 cells to amsacrine and etoposide.
Molecular pharmacology 1999;56(6):1340-5.
1998: M Aoyama; Dale R Grabowski; G R Dubyak; A I Constantinou; LA Rybicki; Ronald M Bukowski; Mahrukh K Ganapathi; Ian D Hickson; Ram Ganapathi
Attenuation of drug-stimulated topoisomerase II-DNA cleavable complex formation in wild-type HL-60 cells treated with an intracellular calcium buffer is correlated with decreased cytotoxicity and site-specific hypophosphorylation of topoisomerase IIalpha.
The Biochemical journal 1998;336 ( Pt 3)():727-33.
1998: M Aoyama; Dale R Grabowski; R J Isaacs; KA Krivacic; LA Rybicki; Ronald M Bukowski; Mahrukh K Ganapathi; Ian D Hickson; Ram Ganapathi
Altered expression and activity of topoisomerases during all-trans retinoic acid-induced differentiation of HL-60 cells.
Blood 1998;92(8):2863-70.
1998: Dale R Grabowski; G R Dubyak; Lisa Rybicki; H Hidaka; Ram Ganapathi
Tumor cell resistance to topoisomerase II poisons: role for intracellular free calcium in the sensitization by inhibitors or calcium-calmodulin-dependent enzymes.
Biochemical pharmacology 1998;56(3):345-9.
1996: K Kawamura; Dale R Grabowski; KA Krivacic; H Hidaka; Ram Ganapathi
Cellular events involved in the sensitization of etoposide-resistant cells by inhibitors of calcium-calmodulin-dependent processes. Role for effects on apoptosis, DNA cleavable complex, and phosphorylation.
Biochemical pharmacology 1996;52(12):1903-9.
1996: Dale R Grabowski; Ram Ganapathi
Cytotoxic efficacy with combinations of topoisomerase I and topoisomerase II inhibitors in sensitive and multidrug-resistant L1210 mouse leukemia cells.
Annals of the New York Academy of Sciences 1996;803():306-7.
1996: Ram Ganapathi; Andreas I Constantinou; N Kamath; G Dubyak; Dale R Grabowski; KA Krivacic
Resistance to etoposide in human leukemia HL-60 cells: reduction in drug-induced DNA cleavage associated with hypophosphorylation of topoisomerase II phosphopeptides.
Molecular pharmacology 1996;50(2):243-8.
1996: Ram Ganapathi; Gerald A Hoeltge; G Casey; Dale R Grabowski; R Neelon; J Ford
Acquisition of doxorubicin resistance in human leukemia HL-60 cells is reproducibly associated with 7q21 chromosomal anomalies.
Cancer genetics and cytogenetics 1996;86(2):116-9.
1996: K I Kawamura; Dale R Grabowski; K Weizer; Ronald Bukowski; Ram Ganapathi
Modulation of vinblastine cytotoxicity by dilantin (phenytoin) or the protein phosphatase inhibitor okadaic acid involves the potentiation of anti-mitotic effects and induction of apoptosis in human tumour cells.
British journal of cancer 1996;73(2):183-8.
1993: Ram Ganapathi; Aleck A Hercbergs; Dale R Grabowski; J Ford
Selective enhancement of vincristine cytotoxicity in multidrug-resistant tumor cells by dilantin (phenytoin)
Cancer research 1993;53(14):3262-5.
1993: N Kamath; Dale R Grabowski; J Ford; Ram Ganapathi
Calmodulin inhibitor trifluoperazine in combination with doxorubicin induces the selection of tumour cells with the multidrug resistant phenotype.
British journal of cancer 1993;67(6):1203-8.
1993: Ram Ganapathi; L Zwelling; Andreas I Constantinou; J Ford; Dale R Grabowski
Altered phosphorylation, biosynthesis and degradation of the 170 kDa isoform of topoisomerase II in amsacrine-resistant human leukemia cells.
Biochemical and biophysical research communications 1993;192(3):1274-80.
1992: N Kamath; Dale R Grabowski; J Ford; D Kerrigan; Y Pommier; Ram Ganapathi
Overexpression of P-glycoprotein and alterations in topoisomerase II in P388 mouse leukemia cells selected in vivo for resistance to mitoxantrone.
Biochemical pharmacology 1992;44(5):937-45.
1992: Subhash C Gautam; N F Chikkala; I Lewis; Dale R Grabowski; James H Finke; Ram Ganapathi
Therapeutic efficacy of interleukin-2 activated killer cells against adriamycin resistant mouse B16-BL6 melanoma.
Anticancer research 1992;12(3):921-5.
1991: Ram Ganapathi; N Kamath; Andreas I Constantinou; Dale R Grabowski; J Ford; A Anderson
Effect of the calmodulin inhibitor trifluoperazine on phosphorylation of P-glycoprotein and topoisomerase II: relationship to modulation of subcellular distribution, DNA damage and cytotoxicity of doxorubicin in multidrug resistant L1210 mouse leukemia cells.
Biochemical pharmacology 1991;41(12):R21-6.
1991: N Kamath; Dale R Grabowski; J Ford; F Drake; D Kerrigan; Y Pommier; Ram Ganapathi
Trifluoperazine modulation of resistance to the topoisomerase II inhibitor etoposide in doxorubicin resistant L1210 murine leukemia cells.
Cancer communications 1991;3(2):37-44.
1991: Ram Ganapathi; T Kuo; L Teeter; Dale R Grabowski; J Ford
Relationship between expression of P-glycoprotein and efficacy of trifluoperazine in multidrug-resistant cells.
Molecular pharmacology 1991;39(1):1-8.
1990: G Thomas Budd; A Jayaraj; Dale R Grabowski; David J Adelstein; L Bauer; J Boyett; Ronald Bukowski; S Murthy; J Weick
Phase I trial of dipyridamole with 5-fluorouracil and folinic acid.
Cancer research 1990;50(22):7206-11.
1990: Ram Ganapathi; Dale R Grabowski; Gerald A Hoeltge; R Neelon
Modulation of doxorubicin-induced chromosomal damage by calmodulin inhibitors and its relationship to cytotoxicity in progressively doxorubicin-resistant tumor cells.
Biochemical pharmacology 1990;40(7):1657-62.
1989: Ram Ganapathi; Dale R Grabowski; T W Sweatman; R Seshadri; M Israel
N-benzyladriamycin-14-valerate versus progressively doxorubicin-resistant murine tumours: cellular pharmacology and characterisation of cross-resistance in vitro and in vivo.
British journal of cancer 1989;60(6):819-26.
1989: Ram Ganapathi; Dale R Grabowski; J Ford; C Heiss; D Kerrigan; Y Pommier
Progressive resistance to doxorubicin in mouse leukemia L1210 cells with multidrug resistance phenotype: reductions in drug-induced topoisomerase II-mediated DNA cleavage.
Cancer communications 1989;1(4):217-24.
1988: Ram Ganapathi; H Schmidt; Dale R Grabowski; M Melia; N Ratliff
Modulation in vitro and in vivo of cytotoxicity but not cellular levels of doxorubicin by the calmodulin inhibitor trifluoperazine is dependent on the level of resistance.
British journal of cancer 1988;58(3):335-40.
1988: Ram Ganapathi; Dale R Grabowski
Differential effect of the calmodulin inhibitor trifluoperazine in modulating cellular accumulation, retention and cytotoxicity of doxorubicin in progressively doxorubicin-resistant L1210 mouse leukemia cells. Lack of correlation between cellular doxorubicin levels and expression of resistance.
Biochemical pharmacology 1988;37(2):185-93.
1987: Ram Ganapathi; Dale R Grabowski; H Schmidt; D Bell; M Melia
Characterization in vitro and in vivo of progressively adriamycin-resistant B16-BL6 mouse melanoma cells.
Cancer research 1987;47(13):3464-8.
1986: Ram Ganapathi; Dale R Grabowski; H Schmidt; A Yen; G Iliakis
Modulation of adriamycin and N-trifluoroacetyladriamycin-14-valerate induced effects on cell cycle traverse and cytotoxicity in P388 mouse leukemia cells by caffeine and the calmodulin inhibitor trifluoperazine.
Cancer research 1986;46(11):5553-7.
1986: Ram Ganapathi; A Yen; Dale R Grabowski; H Schmidt; R Turinic; Rafael Valenzuela
Role of the calmodulin inhibitor trifluoperazine on the induction and expression of cell cycle traverse perturbations and cytotoxicity of daunorubicin and doxorubicin (adriamycin) in doxorubicin-resistant P388 mouse leukaemia cells.
British journal of cancer 1986;53(4):561-6.
1986: Ram Ganapathi; Dale R Grabowski; H Schmidt
Factors governing the modulation of vinca-alkaloid resistance in doxorubicin-resistant cells by the calmodulin inhibitor trifluoperazine.
Biochemical pharmacology 1986;35(4):673-8.
1985: Ram Ganapathi; Dale R Grabowski; H Schmidt; R Seshadri; M Israel
Calmodulin inhibitor trifluoperazine selectively enhances cytotoxic effects of strong vs weak DNA binding antitumor drugs in doxorubicin-resistant P388 mouse leukemia cells.
Biochemical and biophysical research communications 1985;131(2):912-9.
1985: Ram Ganapathi; P Gulick; R Miller; Dale R Grabowski; R Turinic; R Valeunzuela; A Fishleder; Ronald Bukowski
Analysis of heterogeneity in daunorubicin uptake by human leukemia cells using laser flow cytometry.
Investigational new drugs 1985;3(3):273-7.
1984: Ram Ganapathi; Dale R Grabowski; William A. Rouse; F Riegler
Differential effect of the calmodulin inhibitor trifluoperazine on cellular accumulation, retention, and cytotoxicity of anthracyclines in doxorubicin (adriamycin)-resistant P388 mouse leukemia cells.
Cancer research 1984;44(11):5056-61.
1984: Ram Ganapathi; Dale R Grabowski; R Turinic; Rafael Valenzuela
Correlation between potency of calmodulin inhibitors and effects on cellular levels and cytotoxic activity of doxorubicin (adriamycin) in resistant P388 mouse leukemia cells.
European journal of cancer & clinical oncology 1984;20(6):799-806.
1983: Ram Ganapathi; Dale R Grabowski
Enhancement of sensitivity to adriamycin in resistant P388 leukemia by the calmodulin inhibitor trifluoperazine.
Cancer research 1983;43(8):3696-9.