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Jeremy Graff

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Jessica K Altman; Heather Glaser; Jeremy R Graff; Philip W Iversen; Bruce W Konicek; Barbara Kroczynska; Antonella Sassano; Amy Szilard; Eliza Vakana; Leonidas C Platanias
Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors.
Chad A Dumstorf; Bruce W Konicek; Ann M McNulty; Stephen H Parsons; Luc Furic; Nahum Sonenberg; Jeremy R Graff
Modulation of 4E-BP1 function as a critical determinant of enzastaurin-induced apoptosis.
Jeremy R Graff; Bruce W Konicek; Rebecca L Lynch; Chad A Dumstorf; Michele S Dowless; Ann M McNulty; Stephen H Parsons; Leslie H Brail; Bruce M Colligan; Jonathan W Koop; Bernadette M Hurst; james deddens; Blake Lee Neubauer; Louis F Stancato; Harry W Carter; Larry E Douglass; Julia H Carter
eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival.

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2013: Jessica K Altman; Heather Glaser; Jeremy R Graff; Philip W Iversen; Bruce W Konicek; Barbara Kroczynska; Antonella Sassano; Amy Szilard; Eliza Vakana; Leonidas C Platanias
Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors.
Blood 2013;121(18):3675-81.
2010: Chad A Dumstorf; Bruce W Konicek; Ann M McNulty; Stephen H Parsons; Luc Furic; Nahum Sonenberg; Jeremy R Graff
Modulation of 4E-BP1 function as a critical determinant of enzastaurin-induced apoptosis.
Molecular cancer therapeutics 2010;9(12):3158-63.
2009: Jeremy R Graff; Bruce W Konicek; Rebecca L Lynch; Chad A Dumstorf; Michele S Dowless; Ann M McNulty; Stephen H Parsons; Leslie H Brail; Bruce M Colligan; Jonathan W Koop; Bernadette M Hurst; james deddens; Blake Lee Neubauer; Louis F Stancato; Harry W Carter; Larry E Douglass; Julia H Carter
eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival.
Cancer research 2009;69(9):3866-73.
2008: Jeremy R Graff; Bruce W Konicek; Julia H Carter; Eric G Marcusson
Targeting the eukaryotic translation initiation factor 4E for cancer therapy.
Cancer research 2008;68(3):631-4.
2007: Jeremy R Graff; Bruce W Konicek; Thomas M Vincent; Rebecca L Lynch; David Monteith; Spring N Weir; Phil Schwier; Andrew Capen; Robin L Goode; Michele S Dowless; Yuefeng Chen; Hong Zhang; Sean Sissons; Karen Cox; Ann M McNulty; Stephen H Parsons; Tao Wang; Lillian Sams; Sandaruwan Geeganage; Larry E Douglass; Blake Lee Neubauer; Nicholas Dean; Kerry Blanchard; Jianyong Shou; Louis F Stancato; Julia H Carter; Eric G Marcusson
Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity.
The Journal of clinical investigation 2007;117(9):2638-48.
2006: Taiping Chen; Chad Robert Jackson; Andrew Link; Michael P Markey; Bruce M Colligan; Larry E Douglass; Jackson O Pemberton; james deddens; Jeremy R Graff; Julia H Carter
Int7G24A variant of transforming growth factor-beta receptor type I is associated with invasive breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(2):392-7.
2005: Jeremy R Graff; Ann M McNulty; Kimberly Ross Hanna; Bruce W Konicek; Rebecca L Lynch; Spring N Bailey; Crystal Banks; Andrew Capen; Robin L Goode; Jason E Lewis; Lillian Sams; Karen L Huss; Robert M Campbell; Philip W Iversen; Blake Lee Neubauer; Thomas J Brown; Luna Musib; Sandaruwan Geeganage; Donald Thornton
The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts.
Cancer research 2005;65(16):7462-9.
2005: Rebecca L Lynch; Bruce W Konicek; Ann M McNulty; Kimberly R Hanna; Jason E Lewis; Blake Lee Neubauer; Jeremy R Graff
The progression of LNCaP human prostate cancer cells to androgen independence involves decreased FOXO3a expression and reduced p27KIP1 promoter transactivation.
Molecular cancer research : MCR 2005;3(3):163-9.
2004: Taiping Chen; Chad Jackson; Ben Costello; Natalie Singer; Bruce M Colligan; Larry E Douglass; Jackson Pemberton; james deddens; Jeremy R Graff; Julia H Carter
An intronic variant of the TGFBR1 gene is associated with carcinomas of the kidney and bladder.
International journal of cancer. Journal international du cancer 2004;112(3):420-5.
2004: Michael Lahn; Chen Su; Shuyu Li; Marcio Chedid; Kimberly R Hanna; Jeremy R Graff; George E Sandusky; Doreen Ma; Clet Niyikiza; Karen Sundell; William J John; Thomas J Giordano; David G Beer; Blake M Paterson; Eric W Su; Thomas F Bumol
Expression levels of protein kinase C-alpha in non-small-cell lung cancer.
Clinical lung cancer 2004;6(3):184-9.
2004: Julia H Carter; Larry E Douglass; james deddens; Bruce M Colligan; Tejal R Bhatt; Jackson O Pemberton; Susan Konicek; Joanne Hom; Mark Marshall; Jeremy R Graff
Pak-1 expression increases with progression of colorectal carcinomas to metastasis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(10):3448-56.
2004: Arrigo De Benedetti; Jeremy R Graff
eIF-4E expression and its role in malignancies and metastases.
Oncogene 2004;23(18):3189-99.
2003: Blake Lee Neubauer; Ann M McNulty; Marcio Chedid; Keyue Chen; Robin L Goode; Mac A Johnson; C David Jones; Venkatesh Krishnan; Rebecca Lynch; Harold E Osborne; Jeremy R Graff
The selective estrogen receptor modulator trioxifene (LY133314) inhibits metastasis and extends survival in the PAIII rat prostatic carcinoma model.
Cancer research 2003;63(18):6056-62.
2003: Jeremy R Graff; Stephen G Zimmer
Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs.
Clinical & experimental metastasis 2003;20(3):265-73.
2002: Jeremy R Graff
Emerging targets in the AKT pathway for treatment of androgen-independent prostatic adenocarcinoma.
Expert opinion on therapeutic targets 2002;6(1):103-13.
2002: Jiazhong Jiang; Blake Lee Neubauer; Jeremy R Graff; Marcio Chedid; James E Thomas; Neal W Roehm; Shaobo Zhang; George J Eckert; Michael O Koch; John N Eble; Liang Cheng
Expression of group IIA secretory phospholipase A2 is elevated in prostatic intraepithelial neoplasia and adenocarcinoma.
The American journal of pathology 2002;160(2):667-71.
2001: Jeremy R Graff; Bruce W Konicek; james deddens; Marcio Chedid; Bernadette M Hurst; Bruce M Colligan; Blake Lee Neubauer; Harry W Carter; Julia H Carter
Expression of group IIa secretory phospholipase A2 increases with prostate tumor grade.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(12):3857-61.
2001: M J Zinda; M A Johnson; J D Paul; C Horn; Bruce W Konicek; Z H Lu; George E Sandusky; J E Thomas; Blake Lee Neubauer; M T Lai; Jeremy R Graff
AKT-1, -2, and -3 are expressed in both normal and tumor tissues of the lung, breast, prostate, and colon.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(8):2475-9.
2001: Jeremy R Graff; james deddens; Bruce W Konicek; Bruce M Colligan; Bernadette M Hurst; Harry W Carter; Julia H Carter
Integrin-linked kinase expression increases with prostate tumor grade.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):1987-91.
2001: Taiping Chen; J Triplett; B Dehner; Bernadette M Hurst; Bruce M Colligan; J Pemberton; Jeremy R Graff; Julia H Carter
Transforming growth factor-beta receptor type I gene is frequently mutated in ovarian carcinomas.
Cancer research 2001;61(12):4679-82.
2000: Sharyl J Nass; James G Herman; Edward Gabrielson; Philip W Iversen; F F Parl; Nancy E Davidson; Jeremy R Graff
Aberrant methylation of the estrogen receptor and E-cadherin 5' CpG islands increases with malignant progression in human breast cancer.
Cancer research 2000;60(16):4346-8.
2000: Jeremy R Graff; Bruce W Konicek; Ann M McNulty; Z Wang; Keith A Houck; S Allen; J D Paul; A Hbaiu; R G Goode; George E Sandusky; R L Vessella; Blake Lee Neubauer
Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression.
The Journal of biological chemistry 2000;275(32):24500-5.
2000: Stephen G Zimmer; A DeBenedetti; Jeremy R Graff
Translational control of malignancy: the mRNA cap-binding protein, eIF-4E, as a central regulator of tumor formation, growth, invasion and metastasis.
Anticancer research 2000;20(3A):1343-51.
2000: Jeremy R Graff; Edward Gabrielson; H Fujii; Stephen B Baylin; James G Herman
Methylation patterns of the E-cadherin 5' CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression.
The Journal of biological chemistry 2000;275(4):2727-32.
1999: Kurtis E Bachman; James G Herman; P G Corn; A Merlo; Joseph F Costello; W K Cavenee; Stephen B Baylin; Jeremy R Graff
Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers.
Cancer research 1999;59(4):798-802.
1998: James G Herman; A Umar; Kornelia Polyak; Jeremy R Graff; NITA AHUJA; Jean-Pierre J Issa; Sanford Markowitz; James Willson; Stanley R Hamilton; Kenneth W Kinzler; Michael F Kane; Richard D Kolodner; Bert Vogelstein; T A Kunkel; Stephen B Baylin
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6870-5.
1998: Jeremy R Graff; V E Greenberg; James G Herman; William H Westra; ER Boghaert; Kenneth B Ain; Motoyasu Saji; Martha A Zeiger; Stephen G Zimmer; Stephen B Baylin
Distinct patterns of E-cadherin CpG island methylation in papillary, follicular, Hurthle's cell, and poorly differentiated human thyroid carcinoma.
Cancer research 1998;58(10):2063-6.
1998: Stephen B Baylin; James G Herman; Jeremy R Graff; Paula M Vertino; Jean-Pierre J Issa
Alterations in DNA methylation: a fundamental aspect of neoplasia.
Advances in cancer research 1998;72():141-96.
1997: Jeremy R Graff; Arrigo De Benedetti; J W Olson; P Tamez; Robert A Casero; Stephen G Zimmer
Translation of ODC mRNA and polyamine transport are suppressed in ras-transformed CREF cells by depleting translation initiation factor 4E.
Biochemical and biophysical research communications 1997;240(1):15-20.
1997: Jeremy R Graff; James G Herman; S Myöhänen; Stephen B Baylin; Paula M Vertino
Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation.
The Journal of biological chemistry 1997;272(35):22322-9.
1996: James G Herman; Jeremy R Graff; S Myöhänen; Barry D Nelkin; Stephen B Baylin
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9821-6.
1995: Jeremy R Graff; James G Herman; Rena Lapidus; H Chopra; R Xu; David F Jarrard; William B Isaacs; PAULA PITHA-ROWE; Nancy E Davidson; Stephen B Baylin
E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas.
Cancer research 1995;55(22):5195-9.
1995: Jeremy R Graff; ER Boghaert; Arrigo De Benedetti; D L Tudor; C C Zimmer; S K Chan; Stephen G Zimmer
Reduction of translation initiation factor 4E decreases the malignancy of ras-transformed cloned rat embryo fibroblasts.
International journal of cancer. Journal international du cancer 1995;60(2):255-63.
1993: C W Rinker-Schaeffer; Jeremy R Graff; Arrigo De Benedetti; Stephen G Zimmer; Robert E Rhoads
Decreasing the level of translation initiation factor 4E with antisense RNA causes reversal of ras-mediated transformation and tumorigenesis of cloned rat embryo fibroblasts.
International journal of cancer. Journal international du cancer 1993;55(5):841-7.