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Roland Grafström

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Anatomy

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Physiology

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Oxidation-Reduction

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Astrid Ottosson-Wadlund; Katja Pokrovskaja; Giulio Preta; John D Robertson; Stefan Söderhäll; Roland C Grafström; Dan Grandér; Ingrid Hedenfalk; Mats Heyman; Rebecca Ceder; Bengt Fadeel
Requirement of apoptotic protease-activating factor-1 for bortezomib-induced apoptosis but not for Fas-mediated apoptosis in human leukemic cells.
Rebecca Ceder; Bengt Fadeel; Balvinder K Bloor; Ylva Haig; Annette Hansson; Kristiina Iljin; Marina Merne; Peter R Morgan; Matthias Nees; Karin Roberg; Xi Zheng; Roland C Grafström
Differentiation-promoting culture of competent and noncompetent keratinocytes identifies biomarkers for head and neck cancer.
Magnus L Hansson; Sadollah Mohammadi; Giulio Preta; Stefanie Behmer; Rebecca Ceder; Bengt Fadeel; Roland C Grafström; Annika E Wallberg
MAML1 acts cooperatively with EGR1 to activate EGR1-regulated promoters: implications for nephrogenesis and the development of renal cancer.

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All Publications

2013: Astrid Ottosson-Wadlund; Katja Pokrovskaja; Giulio Preta; John D Robertson; Stefan Söderhäll; Roland C Grafström; Dan Grandér; Ingrid Hedenfalk; Mats Heyman; Rebecca Ceder; Bengt Fadeel
Requirement of apoptotic protease-activating factor-1 for bortezomib-induced apoptosis but not for Fas-mediated apoptosis in human leukemic cells.
Molecular pharmacology 2013;83(1):245-55.
2012: Rebecca Ceder; Bengt Fadeel; Balvinder K Bloor; Ylva Haig; Annette Hansson; Kristiina Iljin; Marina Merne; Peter R Morgan; Matthias Nees; Karin Roberg; Xi Zheng; Roland C Grafström
Differentiation-promoting culture of competent and noncompetent keratinocytes identifies biomarkers for head and neck cancer.
The American journal of pathology 2012;180(2):457-72.
2012: Magnus L Hansson; Sadollah Mohammadi; Giulio Preta; Stefanie Behmer; Rebecca Ceder; Bengt Fadeel; Roland C Grafström; Annika E Wallberg
MAML1 acts cooperatively with EGR1 to activate EGR1-regulated promoters: implications for nephrogenesis and the development of renal cancer.
PloS one 2012;7(9):e46001.
2011: Lovisa Farnebo; Roland C Grafström; Reidar Grénman; Fredrik Jerhammar; Ann-Charlotte Johansson; Lena Thunell; Linda Vainikka; Rebecca Ceder; Karin Roberg
Combining factors on protein and gene level to predict radioresponse in head and neck cancer cell lines.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2011;40(10):739-46.
2010: Chad M Thompson; Rebecca Ceder; Roland C Grafström
Formaldehyde dehydrogenase: beyond phase I metabolism.
Toxicology letters 2010;193(1):1-3.
2009: Chad M Thompson; Babasaheb Sonawane; Roland C Grafström
The ontogeny, distribution, and regulation of alcohol dehydrogenase 3: implications for pulmonary physiology.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(8):1565-71.
2009: Claudia A Staab; M Hellgren; Roland C Grafström; Jan-Olov Höög
Medium-chain fatty acids and glutathione derivatives as inhibitors of S-nitrosoglutathione reduction mediated by alcohol dehydrogenase 3.
Chemico-biological interactions 2009;180(1):113-8.
2009: Claudia A Staab; Johan Alander; Ralf Morgenstern; Roland C Grafström; Jan-Olov Höög
The Janus face of alcohol dehydrogenase 3.
Chemico-biological interactions 2009;178(1-3):29-35.
2009: Chad M Thompson; Roland C Grafström
Commentary: mechanistic considerations for associations between formaldehyde exposure and nasopharyngeal carcinoma.
Environmental health : a global access science source 2009;8():53.
2008: Chad M Thompson; Ravi P Subramaniam; Roland C Grafström
Mechanistic and dose considerations for supporting adverse pulmonary physiology in response to formaldehyde.
Toxicology and applied pharmacology 2008;233(3):355-9.
2008: Claudia A Staab; R Ceder; Karin Roberg; Roland C Grafström; Jan-Olov Höög
Serum-responsive expression of carbonyl-metabolizing enzymes in normal and transformed human buccal keratinocytes.
Cellular and molecular life sciences : CMLS 2008;65(22):3653-63.
2008: Karin Roberg; Rebecca Ceder; Lovisa Farnebo; Lena Norberg-Spaak; Roland C Grafström
Multiple genotypic aberrances associate to terminal differentiation-deficiency of an oral squamous cell carcinoma in serum-free culture.
Differentiation; research in biological diversity 2008;76(8):868-80.
2008: Claudia A Staab; Johan Alander; Margareta Brandt; Johan Lengqvist; Ralf Morgenstern; Roland C Grafström; Jan-Olov Höög
Reduction of S-nitrosoglutathione by alcohol dehydrogenase 3 is facilitated by substrate alcohols via direct cofactor recycling and leads to GSH-controlled formation of glutathione transferase inhibitors.
The Biochemical journal 2008;413(3):493-504.
2008: Chad M Thompson; Roland C Grafström
Mechanistic considerations for formaldehyde-induced bronchoconstriction involving S-nitrosoglutathione reductase.
Journal of toxicology and environmental health. Part A 2008;71(3):244-8.
2007: Rebecca Ceder; Marina Merne; Claudia A Staab; Jan-Anders Nilsson; Jan-Olov Höög; Dirk Dressler; Karin Engelhart; Roland C Grafström
The application of normal, SV40 T-antigen-immortalised and tumour-derived oral keratinocytes, under serum-free conditions, to the study of the probability of cancer progression as a result of environmental exposure to chemicals.
Alternatives to laboratory animals : ATLA 2007;35(6):621-39.
2007: Claudia A Staab; Rebecca Ceder; Theres Jägerbrink; Jan-Anders Nilsson; Karin Roberg; Hans Jörnvall; Jan-Olov Höög; Roland C Grafström
Bioinformatics processing of protein and transcript profiles of normal and transformed cell lines indicates functional impairment of transcriptional regulators in buccal carcinoma.
Journal of proteome research 2007;6(9):3705-17.
2004: Claudia A Staab; Martin Vondracek; Hipolito Custodio; Katarina Johansson; Jan-Anders Nilsson; Peter Morgan; Jan-Olov Höög; Ian A Cotgreave; Roland C Grafström
Modelling of normal and premalignant oral tissue by using the immortalised cell line, SVpgC2a: a review of the value of the model.
Alternatives to laboratory animals : ATLA 2004;32(4):401-5.
2004: Jan-Anders Nilsson; Jesper J Hedberg; Martin Vondracek; Claudia A Staab; A Hansson; Jan-Olov Höög; Roland C Grafström
Alcohol dehydrogenase 3 transcription associates with proliferation of human oral keratinocytes.
Cellular and molecular life sciences : CMLS 2004;61(5):610-7.
2003: Zsolt Sarang; Ylva Haig; Annette Hansson; Martin Vondracek; Lars Wärngård; Roland C Grafström
Microarray assessment of fibronectin, collagen and integrin expression and the role of fibronectin-collagen coating in the growth of normal, SV40 T-antigen-immortalised and malignant human oral keratinocytes.
Alternatives to laboratory animals : ATLA 2003;31(6):575-85.
2003: Annette Hansson; Balvinder K Bloor; Zsolt Sarang; Ylva Haig; Peter R Morgan; Hans-Jürgen Stark; Norbert E Fusenig; Jan Ekstrand; Roland C Grafström
Analysis of proliferation, apoptosis and keratin expression in cultured normal and immortalized human buccal keratinocytes.
European journal of oral sciences 2003;111(1):34-41.
2002: Martin Vondracek; David Anthony Weaver; Zsolt Sarang; Jesper J Hedberg; James Willey; Lars Wärngård; Roland C Grafström
Transcript profiling of enzymes involved in detoxification of xenobiotics and reactive oxygen in human normal and simian virus 40 T antigen-immortalized oral keratinocytes.
International journal of cancer. Journal international du cancer 2002;99(6):776-82.
2002: Dirk Dressler; Zsolt Sarang; Zsuzsa Szondy; Karin Engelhart; Roland C Grafström
Expression of retinoid-related genes in serum-free cultures of normal, immortalized and malignant human oral keratinocytes.
International journal of oncology 2002;20(5):897-903.
2001: Erin L Crawford; G J Peters; Paul Noordhuis; Marianne G Rots; Martin Vondracek; Roland C Grafström; K Lieuallen; GG Lennon; Robert J Zahorchak; M J Georgeson; Anil Wali; J F Lechner; PS Fan; M Bashar Kahaleh; Sadik A Khuder; Kristy A Warner; David Anthony Weaver; James Willey
Reproducible gene expression measurement among multiple laboratories obtained in a blinded study using standardized RT (StaRT)-PCR.
Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology 2001;6(4):217-25.
2001: Jesper J Hedberg; Roland C Grafström; Martin Vondracek; Zsolt Sarang; Lars Wärngård; Jan-Olov Höög
Micro-array chip analysis of carbonyl-metabolising enzymes in normal, immortalised and malignant human oral keratinocytes.
Cellular and molecular life sciences : CMLS 2001;58(11):1719-26.
2001: A Hansson; Balvinder K Bloor; Ylva Haig; Peter R Morgan; J Ekstrand; Roland C Grafström
Expression of keratins in normal, immortalized and malignant oral epithelia in organotypic culture.
Oral oncology 2001;37(5):419-30.
2001: Jesper J Hedberg; Annette Hansson; Jan-Anders Nilsson; Jan-Olov Höög; Roland C Grafström
Uniform expression of alcohol dehydrogenase 3 in epithelia regenerated with cultured normal, immortalised and malignant human oral keratinocytes.
Alternatives to laboratory animals : ATLA 2001;29(3):325-33.
2001: Martin Vondracek; Z Xi; P Larsson; V Baker; K Mace; A Pfeifer; H Tjälve; M T Donato; M J Gomez-Lechon; Roland C Grafström
Cytochrome P450 expression and related metabolism in human buccal mucosa.
Carcinogenesis 2001;22(3):481-8.
2000: Jesper J Hedberg; Jan-Olov Höög; Jan-Anders Nilsson; Z Xi; A Elfwing; Roland C Grafström
Expression of alcohol dehydrogenase 3 in tissue and cultured cells from human oral mucosa.
The American journal of pathology 2000;157(5):1745-55.
1998: J A Nilsson; X Zheng; K Sundqvist; Y Liu; Luigi Atzori; A Elfwing; K Arvidson; Roland C Grafström
Toxicity of formaldehyde to human oral fibroblasts and epithelial cells: influences of culture conditions and role of thiol status.
Journal of dental research 1998;77(11):1896-903.
1998: C E Vaca; Jan-Anders Nilsson; J L Fang; Roland C Grafström
Formation of DNA adducts in human buccal epithelial cells exposed to acetaldehyde and methylglyoxal in vitro.
Chemico-biological interactions 1998;108(3):197-208.
1997: Y Liu; Suzanne Egyhazi; Johan Hansson; S V Bhide; P S Kulkarni; Roland C Grafström
O6-methylguanine-DNA methyltransferase activity in human buccal mucosal tissue and cell cultures. Complex mixtures related to habitual use of tobacco and betel quid inhibit the activity in vitro.
Carcinogenesis 1997;18(10):1889-95.
1997: Roland C Grafström; U G Norén; X Zheng; A Elfwing; K Sundqvist
Growth and transformation of human oral epithelium in vitro.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1997;143():275-306.
1996: Galina Selivanova; V Iotsova; E Kiseleva; M Ström; Georgy Bakalkin; Roland C Grafström; Klas G Wiman
The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region.
Nucleic acids research 1996;24(18):3560-7.
1996: P S Kulkarni Schmidt-Kastner; T Heiden; B Tribukait; Roland C Grafström
Non-tumorigenic SV40T immortalized human buccal epithelial cells show aneuploidy and genetic instability.
Anticancer research 1996;16(5A):2681-6.
1995: P S Kulkarni; K Sundqvist; C Betsholtz; P Höglund; Klas G Wiman; B Zhivotovsky; F Bertolero; Y Liu; Roland C Grafström
Characterization of human buccal epithelial cells transfected with the simian virus 40 T-antigen gene.
Carcinogenesis 1995;16(10):2515-21.
1994: Roland C Grafström; J M Dypbukt; K Sundqvist; Luigi Atzori; I Nielsen; rodger curren; Curtis C Harris
Pathobiological effects of acetaldehyde in cultured human epithelial cells and fibroblasts.
Carcinogenesis 1994;15(5):985-90.
1994: Luigi Atzori; J M Dypbukt; S S Hybbinette; P Moldéus; Roland C Grafström
Modifications of cellular thiols during growth and squamous differentiation of cultured human bronchial epithelial cells.
Experimental cell research 1994;211(1):115-20.
1993: Y Liu; K Sundqvist; S A Belinsky; A Castonguay; H Tjälve; Roland C Grafström
Metabolism and macromolecular interaction of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in cultured explants and epithelial cells of human buccal mucosa.
Carcinogenesis 1993;14(11):2383-8.
1993: J M Dypbukt; Luigi Atzori; C C Edman; Roland C Grafström
Thiol status and cytopathological effects of acrolein in normal and xeroderma pigmentosum skin fibroblasts.
Carcinogenesis 1993;14(5):975-80.
1993: Roland C Grafström; I C Hsu; Curtis C Harris
Mutagenicity of formaldehyde in Chinese hamster lung fibroblasts: synergy with ionizing radiation and N-nitroso-N-methylurea.
Chemico-biological interactions 1993;86(1):41-9.
1992: Y Liu; Ian A Cotgreave; Luigi Atzori; Roland C Grafström
The mechanism of Hg2+ toxicity in cultured human oral fibroblasts: the involvement of cellular thiols.
Chemico-biological interactions 1992;85(1):69-78.
1992: K Sundqvist; Roland C Grafström
Effects of areca nut on growth, differentiation and formation of DNA damage in cultured human buccal epithelial cells.
International journal of cancer. Journal international du cancer 1992;52(2):305-10.
1991: Y Liu; Kristina Arvidson; Luigi Atzori; K Sundqvist; B Silva; Ian A Cotgreave; Roland C Grafström
Development of low- and high-serum culture conditions for use of human oral fibroblasts in toxicity testing of dental materials.
Journal of dental research 1991;70(7):1068-73.
1991: K Sundqvist; Y Liu; Kristina Arvidson; K Ormstad; L Nilsson; R Toftgård; Roland C Grafström
Growth regulation of serum-free cultures of epithelial cells from normal human buccal mucosa.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1991;27A(7):562-8.
1991: Kristina Arvidson; B Fartash; LE Moberg; Roland C Grafström; Ingvar Ericsson
In vitro and in vivo experimental studies on single crystal sapphire dental implants.
Clinical oral implants research 1991;2(2):47-55.
1991: K Sundqvist; Y Liu; P Erhardt; jagadeesan nair; H Bartsch; Roland C Grafström
Areca-nut toxicity in cultured human buccal epithelial cells.
IARC scientific publications 1991;(105):281-5.
1991: K Sundqvist; P Kulkarni; S S Hybbinette; F Bertolero; Y Liu; Roland C Grafström
Serum-free growth and karyotype analyses of cultured normal and tumorous (SqCC/Y1) human buccal epithelial cells.
Cancer communications 1991;3(10-11):331-40.
1990: Roland C Grafström
In vitro studies of aldehyde effects related to human respiratory carcinogenesis.
Mutation research 1990;238(3):175-84.
1990: Luigi Atzori; J M Dypbukt; K Sundqvist; Ian A Cotgreave; C C Edman; P Moldéus; Roland C Grafström
Growth-associated modifications of low-molecular-weight thiols and protein sulfhydryls in human bronchial fibroblasts.
Journal of cellular physiology 1990;143(1):165-71.
1990: Roland C Grafström
Carcinogenesis studies in human epithelial tissues and cells in vitro: emphasis on serum-free culture conditions and transformation studies.
Acta physiologica Scandinavica. Supplementum 1990;592():93-133.
1989: J M Dypbukt; C C Edman; K Sundqvist; T Kakefuda; S M Plummer; Curtis C Harris; Roland C Grafström
Reactivity of fecapentaene-12 toward thiols, DNA, and these constituents in human fibroblasts.
Cancer research 1989;49(21):6058-63.
1989: K Sundqvist; Y Liu; jagadeesan nair; H Bartsch; Kristina Arvidson; Roland C Grafström
Cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells.
Cancer research 1989;49(19):5294-8.
1988: Roland C Grafström; J M Dypbukt; James Willey; K Sundqvist; C Edman; Luigi Atzori; Curtis C Harris
Pathobiological effects of acrolein in cultured human bronchial epithelial cells.
Cancer research 1988;48(7):1717-21.
1988: Kristina Arvidson; Roland C Grafström; A Pemer
Scanning electron microscopy of oral mucosa in vivo and in vitro: a review.
Scanning microscopy 1988;2(1):385-96.
1987: Roland C Grafström; K Sundqvist; J M Dypbukt; Curtis C Harris
Pathobiological effects of aldehydes in cultured human bronchial cells.
IARC scientific publications 1987;(84):443-5.
1986: Roland C Grafström; rodger curren; L L Yang; Curtis C Harris
Aldehyde-induced inhibition of DNA repair and potentiation of N-nitrosocompound-induced mutagenesis in cultured human cells.
Progress in clinical and biological research 1986;209A():255-64.