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Steven Graham

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Hao Liu; Mioara D Manole; Marie Rose; Syana M Sarnaik; Sunita N Shinde; Henry Alexander; Jie Chen; Yaming Chen; Robert S B Clark; Steven H Graham; Wenjin Li; Robert W Hickey
Increased cytochrome c in rat cerebrospinal fluid after cardiac arrest and its effects on hypoxic neuronal survival.
Hao Liu; Wenjin Li; Muzamil Ahmad; Tricia M Miller; Marie E Rose; Samuel M Poloyac; Guy Uechi; Manimalha Balasubramani; Robert W Hickey; Steven H Graham
Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury.
Wenjin Li; Shasha Wu; Muzamil Ahmad; Jianfei Jiang; Hao Liu; Tetsuya Nagayama; Marie E Rose; Vladimir A Tyurin; Yulia Y Tyurina; Grigory G Borisenko; Natalia Belikova; Jun Chen; Valerian E Kagan; Steven H Graham
The cyclooxygenase site, but not the peroxidase site of cyclooxygenase-2 is required for neurotoxicity in hypoxic and ischemic injury.

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2012: Hao Liu; Mioara D Manole; Marie Rose; Syana M Sarnaik; Sunita N Shinde; Henry Alexander; Jie Chen; Yaming Chen; Robert S B Clark; Steven H Graham; Wenjin Li; Robert W Hickey
Increased cytochrome c in rat cerebrospinal fluid after cardiac arrest and its effects on hypoxic neuronal survival.
Resuscitation 2012;83(12):1491-6.
2011: Hao Liu; Wenjin Li; Muzamil Ahmad; Tricia M Miller; Marie E Rose; Samuel M Poloyac; Guy Uechi; Manimalha Balasubramani; Robert W Hickey; Steven H Graham
Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury.
Neurobiology of disease 2011;41(2):318-28.
2010: Wenjin Li; Shasha Wu; Muzamil Ahmad; Jianfei Jiang; Hao Liu; Tetsuya Nagayama; Marie E Rose; Vladimir A Tyurin; Yulia Y Tyurina; Grigory G Borisenko; Natalia Belikova; Jun Chen; Valerian E Kagan; Steven H Graham
The cyclooxygenase site, but not the peroxidase site of cyclooxygenase-2 is required for neurotoxicity in hypoxic and ischemic injury.
Journal of neurochemistry 2010;113(4):965-77.
2010: Leonardus M I Koharudin; Hao Liu; Roberto Di Maio; Ravindra B Kodali; Steven H Graham; Angela M Gronenborn
Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(15):6835-40.
2009: Peter S Vosler; Steven H Graham; Lawrence R Wechsler; Jun Chen
Mitochondrial targets for stroke: focusing basic science research toward development of clinically translatable therapeutics.
Stroke; a journal of cerebral circulation 2009;40(9):3149-55.
2009: Muzamil Ahmad; Yuquin Zhang; Hao Liu; Marie E Rose; Steven H Graham
Prolonged opportunity for neuroprotection in experimental stroke with selective blockade of cyclooxygenase-2 activity.
Brain research 2009;1279():168-73.
2008: R Anne Stetler; Guodong Cao; Yanqin Gao; Feng Zhang; Suping Wang; Zhongfang Weng; Peter Vosler; Lili Zhang; Armando Signore; Steven H Graham; Jun Chen
Hsp27 protects against ischemic brain injury via attenuation of a novel stress-response cascade upstream of mitochondrial cell death signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(49):13038-55.
2008: Muzamil Ahmad; Marie E Rose; Vincent Vagni; Raymond P Griffith; C Edward Dixon; Patrick M Kochanek; Robert W Hickey; Steven H Graham
Genetic disruption of cyclooxygenase-2 does not improve histological or behavioral outcome after traumatic brain injury in mice.
Journal of neuroscience research 2008;86(16):3605-12.
2008: Ying Mu; Megan M Klamerus; Tricia M Miller; Lisa C Rohan; Steven H Graham; Samuel M Poloyac
Intravenous formulation of N-hydroxy-N'-(4-n-butyl-2-methylphenyl)formamidine (HET0016) for inhibition of rat brain 20-hydroxyeicosatetraenoic acid formation.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(11):2324-30.
2008: Roya Tehranian; Marie E Rose; Vincent A Vagni; Alicia M Pickrell; Raymond P Griffith; Hao Liu; Robert S B Clark; C Edward Dixon; Patrick M Kochanek; Steven H Graham
Disruption of Bax protein prevents neuronal cell death but produces cognitive impairment in mice following traumatic brain injury.
Journal of neurotrauma 2008;25(7):755-67.
2008: Yichen Lai; Robert W Hickey; Yaming Chen; Hülya Bayir; Mara L Sullivan; Charleen T Chu; Patrick M Kochanek; C Edward Dixon; Larry W Jenkins; Steven H Graham; simon simon watkins; Robert S B Clark
Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(3):540-50.
2008: Wenjin Li; Shasha Wu; Robert W Hickey; Marie E Rose; Jun Chen; Steven H Graham
Neuronal cyclooxygenase-2 activity and prostaglandins PGE2, PGD2, and PGF2 alpha exacerbate hypoxic neuronal injury in neuron-enriched primary culture.
Neurochemical research 2008;33(3):490-9.
2007: Robert W Hickey; P David Adelson; Michael J Johnnides; Dwight S Davis; Zhisheng Yu; Marie E Rose; Yue-Fang Chang; Steven H Graham
Cyclooxygenase-2 activity following traumatic brain injury in the developing rat.
Pediatric research 2007;62(3):271-6.
2007: Guodong Cao; Juan Xing; Xiao Xiao; Anthony K F Liou; Yanqin Gao; Xiao-Ming Yin; Robert S B Clark; Steven H Graham; Jun Chen
Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(35):9278-93.
2007: Robert S B Clark; Paula D Nathaniel; Xiaopeng Zhang; C Edward Dixon; Sean Alber; simon simon watkins; John A Melick; Patrick M Kochanek; Steven H Graham
boc-Aspartyl(OMe)-fluoromethylketone attenuates mitochondrial release of cytochrome c and delays brain tissue loss after traumatic brain injury in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(2):316-26.
2006: Samuel M Poloyac; Yuqing Zhang; Robert R Bies; Patrick M Kochanek; Steven H Graham
Protective effect of the 20-HETE inhibitor HET0016 on brain damage after temporary focal ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006;26(12):1551-61.
2006: Xiaopeng Zhang; Sean Alber; simon simon watkins; Patrick M Kochanek; Donald W Marion; Steven H Graham; Robert S B Clark
Proteolysis consistent with activation of caspase-7 after severe traumatic brain injury in humans.
Journal of neurotrauma 2006;23(11):1583-90.
2006: Roya Tehranian; Marie E Rose; Vincent A Vagni; R P Griffith; Shasha Wu; Sara Maits; Xiaopeng Zhang; Robert S B Clark; C Edward Dixon; Patrick M Kochanek; Ora Bernard; Steven H Graham
Transgenic mice that overexpress the anti-apoptotic Bcl-2 protein have improved histological outcome but unchanged behavioral outcome after traumatic brain injury.
Brain research 2006;1101(1):126-35.
2006: Yulia Y Tyurina; Alexandr A Kapralov; Jianfei Jiang; Grigory G Borisenko; Alla I Potapovich; Andrey Sorokin; Patrick M Kochanek; Steven H Graham; Nina F Schor; Valerian E Kagan
Oxidation and cytotoxicity of 6-OHDA are mediated by reactive intermediates of COX-2 overexpressed in PC12 cells.
Brain research 2006;1093(1):71-82.
2006: Yumin Luo; Wei Yin; Armando P Signore; Feng Zhang; Zhen Hong; Suping Wang; Steven H Graham; Jun Chen
Neuroprotection against focal ischemic brain injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone.
Journal of neurochemistry 2006;97(2):435-48.
2005: Kenji Kawaguchi; Robert W Hickey; Marie E Rose; Li Zhu; Jun Chen; Steven H Graham
Cyclooxygenase-2 expression is induced in rat brain after kainate-induced seizures and promotes neuronal death in CA3 hippocampus.
Brain research 2005;1050(1-2):130-7.
2005: Yanqin Gao; Armando P Signore; Wei Yin; Guodong Cao; Xiao-Ming Yin; Fengyan Sun; Yumin Luo; Steven H Graham; Jun Chen
Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(6):694-712.
2004: Ren Wu Chen; Yuqing Zhang; Marie E Rose; Steven H Graham
Cyclooxygenase-2 activity contributes to neuronal expression of cyclin D1 after anoxia/ischemia in vitro and in vivo.
Brain research. Molecular brain research 2004;132(1):31-7.
2004: Lina Du; Hülya Bayir; Yichen Lai; Xiaopeng Zhang; Patrick M Kochanek; simon simon watkins; Steven H Graham; Robert S B Clark
Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway.
The Journal of biological chemistry 2004;279(37):38563-70.
2004: Jianfei Jiang; Grigory G Borisenko; Anatoly Osipov; Ian Martin; Renwu Chen; Anna A Shvedova; Andrey Sorokin; Yulia Y Tyurina; Alla I Potapovich; Vladimir A Tyurin; Steven H Graham; Valerian E Kagan
Arachidonic acid-induced carbon-centered radicals and phospholipid peroxidation in cyclo-oxygenase-2-transfected PC12 cells.
Journal of neurochemistry 2004;90(5):1036-49.
2004: Guodong Cao; Michael Xiao; Fengyan Sun; Xiao Xiao; Wei Pei; J Li; Steven H Graham; Roger P. Simon; Jun Chen
Cloning of a novel Apaf-1-interacting protein: a potent suppressor of apoptosis and ischemic neuronal cell death.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(27):6189-201.
2004: Shasha Wu; Liqiao Zhou; Marie Rose; Xiao Xiao; Steven H Graham
c-FLIP-L recombinant adeno-associated virus vector infection prevents Fas-mediated but not nerve growth factor withdrawal-mediated cell death in PC12 cells.
Brain research. Molecular brain research 2004;122(1):79-87.
2003: Guodong Cao; Robert S B Clark; Wei Pei; Wei Yin; Feng Zhang; Feng-Yan Sun; Steven H Graham; Jun Chen
Translocation of apoptosis-inducing factor in vulnerable neurons after transient cerebral ischemia and in neuronal cultures after oxygen-glucose deprivation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(10):1137-50.
2003: Xiaopeng Zhang; Steven H Graham; Patrick M Kochanek; Donald W Marion; Paula D Nathaniel; simon simon watkins; Robert S B Clark
Caspase-8 expression and proteolysis in human brain after severe head injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(10):1367-9.
2003: Lina Du; Xiaopeng Zhang; Yong Y Han; Nancy A Burke; Patrick M Kochanek; simon simon watkins; Steven H Graham; Joseph A Carcillo; Csaba Szabó; Robert S B Clark
Intra-mitochondrial poly(ADP-ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress.
The Journal of biological chemistry 2003;278(20):18426-33.
2003: Steven H Graham; Robert W Hickey
Cyclooxygenases in central nervous system diseases: a special role for cyclooxygenase 2 in neuronal cell death.
Archives of neurology 2003;60(4):628-30.
2003: Robert W Hickey; Patrick M Kochanek; Howard Ferimer; Henry L Alexander; Robert H Garman; Steven H Graham
Induced hyperthermia exacerbates neurologic neuronal histologic damage after asphyxial cardiac arrest in rats.
Critical care medicine 2003;31(2):531-5.
2003: Neal A Seidberg; Robert S B Clark; Xiaopeng Zhang; Yichen Lai; Minzhi Chen; Steven H Graham; Patrick M Kochanek; simon simon watkins; Donald W Marion
Alterations in inducible 72-kDa heat shock protein and the chaperone cofactor BAG-1 in human brain after head injury.
Journal of neurochemistry 2003;84(3):514-21.
2003: Hülya Bayir; Patrick M Kochanek; Shang-Xi Liu; Antonio Arroyo; Anatoly Osipov; Jianfei Jiang; Stephen R Wisniewski; P David Adelson; Steven H Graham; Valerian E Kagan
Increased S-nitrosothiols and S-nitrosoalbumin in cerebrospinal fluid after severe traumatic brain injury in infants and children: indirect association with intracranial pressure.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(1):51-61.
2002: Marie E Rose; Michele B Huerbin; John A Melick; Donald W Marion; Alan M Palmer; Joanne K Schiding; Patrick M Kochanek; Steven H Graham
Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury.
Brain research 2002;943(1):15-22.
2002: Guodong Cao; Wei Pei; Hailiang Ge; Qinhua Liang; Yumin Luo; Frank R Sharp; Aigang Lu; Ruiqiong Ran; Steven H Graham; Jun Chen
In Vivo Delivery of a Bcl-xL Fusion Protein Containing the TAT Protein Transduction Domain Protects against Ischemic Brain Injury and Neuronal Apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(13):5423-31.
2002: Xiaopeng Zhang; Jun Chen; Steven H Graham; Lina Du; Patrick M Kochanek; Romesh A Draviam; Fengli Guo; Paula D Nathaniel; Csaba Szabó; simon simon watkins; Robert S B Clark
Intranuclear localization of apoptosis-inducing factor (AIF) and large scale DNA fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite.
Journal of neurochemistry 2002;82(1):181-91.
2002: Marie E Rose; Michele B Huerbin; John A Melick; Donald W Marion; Alan M Palmer; Joanne K Schiding; Patrick M Kochanek; Steven H Graham
Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury.
Brain research 2002;935(1-2):40-6.
2002: Hülya Bayir; Valerian E Kagan; Yulia Y Tyurina; Vladimir A Tyurin; Randall A Ruppel; P David Adelson; Steven H Graham; Keri L Janesko; Robert S B Clark; Patrick M Kochanek
Assessment of antioxidant reserves and oxidative stress in cerebrospinal fluid after severe traumatic brain injury in infants and children.
Pediatric research 2002;51(5):571-8.
2002: Guodong Cao; Yumin Luo; Tetsuya Nagayama; Wei Pei; R Anne Stetler; Steven H Graham; Jun Chen
Cloning and characterization of rat caspase-9: implications for a role in mediating caspase-3 activation and hippocampal cell death after transient cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(5):534-46.
2002: Kunlin Jin; Tetsuya Nagayama; Xiaoou Mao; Kenji Kawaguchi; Robert W Hickey; David A Greenberg; Roger P. Simon; Steven H Graham
Two caspase-2 transcripts are expressed in rat hippocampus after global cerebral ischemia.
Journal of neurochemistry 2002;81(1):25-35.
2002: Yumin Luo; Guodong Cao; Wei Pei; Cristine O'Horo; Steven H Graham; Jun Chen
Induction of caspase-activated deoxyribonuclease activity after focal cerebral ischemia and reperfusion.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(1):15-20.
2001: Courtney L Robertson; Michael J Bell; Patrick M Kochanek; P David Adelson; Randall A Ruppel; Joseph A Carcillo; Stephen R Wisniewski; Zaichuan Mi; Keri L Janesko; Robert S B Clark; Donald W Marion; Steven H Graham; Edwin K Jackson
Increased adenosine in cerebrospinal fluid after severe traumatic brain injury in infants and children: association with severity of injury and excitotoxicity.
Critical care medicine 2001;29(12):2287-93.
2001: Kunlin Jin; Steven H Graham; Tetsuya Nagayama; P C Goldsmith; David A Greenberg; An Zhou; Roger P. Simon
Altered expression of the neuropeptide-processing enzyme carboxypeptidase E in the rat brain after global ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(12):1422-9.
2001: Kunlin Jin; Steven H Graham; X Mao; Tetsuya Nagayama; Roger P. Simon; David A Greenberg
Fas (CD95) may mediate delayed cell death in hippocampal CA1 sector after global cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(12):1411-21.
2001: Minzhi Chen; Patrick M Kochanek; simon simon watkins; KL Jin; Romesh A Draviam; Paula D Nathaniel; R Pinto; Donald W Marion; Steven H Graham
Detection of single- and double-strand DNA breaks after traumatic brain injury in rats: comparison of in situ labeling techniques using DNA polymerase I, the Klenow fragment of DNA polymerase I, and terminal deoxynucleotidyl transferase.
Journal of neurotrauma 2001;18(7):675-89.
2001: Guodong Cao; Wei Pei; Jing Lan; R Anne Stetler; Yumin Luo; Tetsuya Nagayama; Steven H Graham; Xiao-Ming Yin; Roger P. Simon; Jun Chen
Caspase-activated DNase/DNA fragmentation factor 40 mediates apoptotic DNA fragmentation in transient cerebral ischemia and in neuronal cultures.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(13):4678-90.
2001: KL Jin; Steven H Graham; Xiao Ou Mao; X He; Tetsuya Nagayama; Roger P. Simon; David A Greenberg
Bax kappa, a novel Bax splice variant from ischemic rat brain lacking an ART domain, promotes neuronal cell death.
Journal of neurochemistry 2001;77(6):1508-19.
2001: Guodong Cao; M Minami; Wei Pei; Chaohua Yan; Dexi Chen; Cristine O'Horo; Steven H Graham; Jun Chen
Intracellular Bax translocation after transient cerebral ischemia: implications for a role of the mitochondrial apoptotic signaling pathway in ischemic neuronal death.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(4):321-33.
2001: S Shimizu; Tetsuya Nagayama; KL Jin; L Zhu; JE Loeffert; simon simon watkins; Steven H Graham; Roger P. Simon
bcl-2 Antisense treatment prevents induction of tolerance to focal ischemia in the rat brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(3):233-43.
2001: Steven H Graham; Jun Chen
Programmed cell death in cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(2):99-109.
2001: Randall A Ruppel; Patrick M Kochanek; P David Adelson; Marie E Rose; Stephen R Wisniewski; Michael J Bell; Robert S B Clark; Donald W Marion; Steven H Graham
Excitatory amino acid concentrations in ventricular cerebrospinal fluid after severe traumatic brain injury in infants and children: the role of child abuse.
The Journal of pediatrics 2001;138(1):18-25.
2000: Kimberly D Statler; Patrick M Kochanek; C Edward Dixon; Henry L Alexander; Warner David; Robert S B Clark; Stephen R Wisniewski; Steven H Graham; Larry W Jenkins; Donald W Marion; Peter Safar
Isoflurane improves long-term neurologic outcome versus fentanyl after traumatic brain injury in rats.
Journal of neurotrauma 2000;17(12):1179-89.
2000: Vladimir A Tyurin; Yulia Y Tyurina; Grigory G Borisenko; Tatyana V Sokolova; Vladimir B Ritov; Peter J Quinn; M Rose; Patrick M Kochanek; Steven H Graham; Valerian E Kagan
Oxidative stress following traumatic brain injury in rats: quantitation of biomarkers and detection of free radical intermediates.
Journal of neurochemistry 2000;75(5):2178-89.
2000: Steven H Graham; Jun Chen; Robert S B Clark
Bcl-2 family gene products in cerebral ischemia and traumatic brain injury.
Journal of neurotrauma 2000;17(10):831-41.
2000: Robert W Hickey; Howard Ferimer; Henry L Alexander; R H Garman; Clifton Callaway; S Hicks; Peter Safar; Steven H Graham; Patrick M Kochanek
Delayed, spontaneous hypothermia reduces neuronal damage after asphyxial cardiac arrest in rats.
Critical care medicine 2000;28(10):3511-6.
2000: Courtney L Robertson; Robert S B Clark; C Edward Dixon; Henry L Alexander; Steven H Graham; Stephen R Wisniewski; Donald W Marion; Peter Safar; Patrick M Kochanek
No long-term benefit from hypothermia after severe traumatic brain injury with secondary insult in rats.
Critical care medicine 2000;28(9):3218-23.
2000: Robert S B Clark; Patrick M Kochanek; P David Adelson; Michael J Bell; Joseph A Carcillo; M Chen; Stephen R Wisniewski; Keri L Janesko; Michael J Whalen; Steven H Graham
Increases in bcl-2 protein in cerebrospinal fluid and evidence for programmed cell death in infants and children after severe traumatic brain injury.
The Journal of pediatrics 2000;137(2):197-204.
2000: Jun Chen; Roger P. Simon; Tetsuya Nagayama; R Zhu; JE Loeffert; simon simon watkins; Steven H Graham
Suppression of endogenous bcl-2 expression by antisense treatment exacerbates ischemic neuronal death.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(7):1033-9.
2000: Robert W Hickey; Patrick M Kochanek; Howard Ferimer; Steven H Graham; Peter Safar
Hypothermia and hyperthermia in children after resuscitation from cardiac arrest.
Pediatrics 2000;106(1 Pt 1):118-22.
2000: Robert W Hickey; RL Zhu; Henry L Alexander; KL Jin; R Anne Stetler; Jun Chen; Patrick M Kochanek; Steven H Graham
10 kD mitochondrial matrix heat shock protein mRNA is induced following global brain ischemia in the rat.
Brain research. Molecular brain research 2000;79(1-2):169-73.
2000: K Jin; W Li; Tetsuya Nagayama; X He; Amy D Sinor; J Chang; X Mao; Steven H Graham; Roger P. Simon; David A Greenberg
Expression of the RNA-binding protein TIAR is increased in neurons after ischemic cerebral injury.
Journal of neuroscience research 2000;59(6):767-74.
2000: Robert S B Clark; Patrick M Kochanek; simon simon watkins; Minzhi Chen; C Edward Dixon; N A Seidberg; John A Melick; JE Loeffert; Paula D Nathaniel; KL Jin; Steven H Graham
Caspase-3 mediated neuronal death after traumatic brain injury in rats.
Journal of neurochemistry 2000;74(2):740-53.
2000: Courtney L Robertson; Kristy S Hendrich; Patrick M Kochanek; Edwin K Jackson; John A Melick; Steven H Graham; Donald W Marion; Donald S Williams; Chien Ho
Assessment of 2-chloroadenosine treatment after experimental traumatic brain injury in the rat using arterial spin-labeled MRI: a preliminary report.
Acta neurochirurgica. Supplement 2000;76():187-9.
2000: W Li; K Jin; Tetsuya Nagayama; X He; J Chang; M Minami; Steven H Graham; Roger P. Simon; David A Greenberg
Increased expression of apoptosis-linked gene 2 (ALG2) in the rat brain after temporary focal cerebral ischemia.
Neuroscience 2000;96(1):161-8.
1999: K Jin; Tetsuya Nagayama; Jun Chen; A R Stetler; Kenji Kawaguchi; Roger P. Simon; Steven H Graham
Molecular cloning of a cell cycle regulation gene cyclin H from ischemic rat brain: expression in neurons after global cerebral ischemia.
Journal of neurochemistry 1999;73(4):1598-608.
1999: Michael J Whalen; Robert S B Clark; C Edward Dixon; P Robichaud; Donald W Marion; Vincent A Vagni; Steven H Graham; Laszlo Virag; G Hasko; R Stachlewitz; Csaba Szabó; Patrick M Kochanek
Reduction of cognitive and motor deficits after traumatic brain injury in mice deficient in poly(ADP-ribose) polymerase.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1999;19(8):835-42.
1999: Robert S B Clark; Patrick M Kochanek; Minzhi Chen; simon simon watkins; D W Marion; Jun Chen; R L Hamilton; JE Loeffert; Steven H Graham
Increases in Bcl-2 and cleavage of caspase-1 and caspase-3 in human brain after head injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(8):813-21.
1999: Tetsuya Nagayama; Amy D Sinor; Roger P. Simon; Jun Chen; Steven H Graham; K Jin; David A Greenberg
Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(8):2987-95.
1999: K Jin; Jun Chen; Tetsuya Nagayama; Minzhi Chen; J Sinclair; Steven H Graham; Roger P. Simon
In situ detection of neuronal DNA strand breaks using the Klenow fragment of DNA polymerase I reveals different mechanisms of neuron death after global cerebral ischemia.
Journal of neurochemistry 1999;72(3):1204-14.
1998: Amy D Sinor; SM Irvin; Charles S Cobbs; Jun Chen; Steven H Graham; David A Greenberg
Hypoxic induction of vascular endothelial growth factor (VEGF) protein in astroglial cultures.
Brain research 1998;812(1-2):289-91.
1998: M Nakayama; K Uchimura; RL Zhu; Tetsuya Nagayama; Marie E Rose; R Anne Stetler; P C Isakson; Jun Chen; Steven H Graham
Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10954-9.
1998: Jun Chen; Tetsuya Nagayama; K Jin; R Anne Stetler; RL Zhu; Steven H Graham; Roger P. Simon
Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(13):4914-28.
1998: Charles S Cobbs; J Chen; D A Greenberg; Steven H Graham
Vascular endothelial growth factor expression in transient focal cerebral ischemia in the rat.
Neuroscience letters 1998;249(2-3):79-82.
1998: Jun Chen; K Uchimura; R Anne Stetler; RL Zhu; M Nakayama; K Jin; Steven H Graham; Roger P. Simon
Transient global ischemia triggers expression of the DNA damage-inducible gene GADD45 in the rat brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1998;18(6):646-57.
1998: Minzhi Chen; Robert S B Clark; Patrick M Kochanek; Jun Chen; Joanne K Schiding; R Anne Stetler; Roger P. Simon; Steven H Graham
72-kDa heat shock protein and mRNA expression after controlled cortical impact injury with hypoxemia in rats.
Journal of neurotrauma 1998;15(3):171-81.
1998: MICHAEL LEIGHTON FORBES; Robert S B Clark; C Edward Dixon; Steven H Graham; Donald W Marion; Steven T DeKosky; Joanne K Schiding; Patrick M Kochanek
Augmented neuronal death in CA3 hippocampus following hyperventilation early after controlled cortical impact.
Journal of neurosurgery 1998;88(3):549-56.
1997: Robert S B Clark; Jun Chen; simon simon watkins; Patrick M Kochanek; Minzhi Chen; R Anne Stetler; JE Loeffert; Steven H Graham
Apoptosis-suppressor gene bcl-2 expression after traumatic brain injury in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(23):9172-82.
1997: RL Zhu; Steven H Graham; J Jin; R Anne Stetler; Roger P. Simon; Jun Chen
Kainate induces the expression of the DNA damage-inducible gene, GADD45, in the rat brain.
Neuroscience 1997;81(3):707-20.
1997: MICHAEL LEIGHTON FORBES; Kristy S Hendrich; Patrick M Kochanek; Donald S Williams; Joanne K Schiding; Stephen R Wisniewski; S F Kelsey; Steven T DeKosky; Steven H Graham; Donald W Marion; Chien Ho
Assessment of cerebral blood flow and CO2 reactivity after controlled cortical impact by perfusion magnetic resonance imaging using arterial spin-labeling in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1997;17(8):865-74.
1997: J Q Lan; Jun Chen; Frank R Sharp; Roger P. Simon; Steven H Graham
Induction of heat-shock protein (HSP72) in the cingulate and retrosplenial cortex by drugs that antagonize the effects of excitatory amino acids.
Brain research. Molecular brain research 1997;46(1-2):297-302.
1997: Robert S B Clark; Patrick M Kochanek; C Edward Dixon; Minzhi Chen; Donald W Marion; S Heineman; Steven T DeKosky; Steven H Graham
Early neuropathologic effects of mild or moderate hypoxemia after controlled cortical impact injury in rats.
Journal of neurotrauma 1997;14(4):179-89.
1997: Kenji Kawaguchi; Steven H Graham
Neuroprotective effects of the glutamate release inhibitor 619C89 in temporary middle cerebral artery occlusion.
Brain research 1997;749(1):131-4.
1997: Jun Chen; Steven H Graham; M Nakayama; RL Zhu; K Jin; R Anne Stetler; Roger P. Simon
Apoptosis repressor genes Bcl-2 and Bcl-x-long are expressed in the rat brain following global ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1997;17(1):2-10.
1996: T Ebisu; WD Rooney; Steven H Graham; A Mancuso; Michael Weiner; Andrew A Maudsley
MR spectroscopic imaging and diffusion-weighted MRI for early detection of kainate-induced status epilepticus in the rat.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1996;36(6):821-8.
1996: K Tanaka; Steven H Graham; Roger P. Simon
The role of excitatory neurotransmitters in seizure-induced neuronal injury in rats.
Brain research 1996;737(1-2):59-63.
1996: K Jin; Jun Chen; Kenji Kawaguchi; RL Zhu; R Anne Stetler; Roger P. Simon; Steven H Graham
Focal ischemia induces expression of the DNA damage-inducible gene GADD45 in the rat brain.
Neuroreport 1996;7(11):1797-802.
1996: Jun Chen; Steven H Graham; RL Zhu; Roger P. Simon
Stress proteins and tolerance to focal cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1996;16(4):566-77.
1996: Jun Chen; RL Zhu; M Nakayama; Kenji Kawaguchi; K Jin; R Anne Stetler; Roger P. Simon; Steven H Graham
Expression of the apoptosis-effector gene, Bax, is up-regulated in vulnerable hippocampal CA1 neurons following global ischemia.
Journal of neurochemistry 1996;67(1):64-71.
1996: Steven H Graham; Jun Chen; R Anne Stetler; RL Zhu; KL Jin; Roger P. Simon
Expression of the proto-oncogene bcl-2 is increased in the rat brain following kainate-induced seizures.
Restorative neurology and neuroscience 1996;9(4):243-50.
1996: Steven H Graham; Jun Chen; R Anne Stetler; RL Zhu; KL Jin; Roger P. Simon
Corrigendum to "Expression of the proto-oncogene bcl-2 is increased in the rat brain following kainate-induced seizures" [Restor. Neurol. Neurosci. 9 (1996) 243].
Restorative neurology and neuroscience 1996;10(3):185.
1996: Steven H Graham; Jun Chen; J Q Lan; Roger P. Simon
A dose-response study of neuroprotection using the AMPA antagonist NBQX in rat focal cerebral ischemia.
The Journal of pharmacology and experimental therapeutics 1996;276(1):1-4.
1995: H Gaspary; Steven H Graham; S M Sagar; Frank R Sharp
HSP70 heat shock protein induction following global ischemia in the rat.
Brain research. Molecular brain research 1995;34(2):327-32.
1995: G J Zarow; Steven H Graham; J Mintorovitch; J Chen; G Yang; Philip R Weinstein
Diffusion-weighted magnetic resonance imaging during brief focal cerebral ischemia and early reperfusion: evolution of delayed infarction in rats.
Neurological research 1995;17(6):449-54.
1995: Jun Chen; Steven H Graham; Roger P. Simon
A comparison of the effects of a sodium channel blocker and an NMDA antagonist upon extracellular glutamate in rat focal cerebral ischemia.
Brain research 1995;699(1):121-4.
1995: A Mancuso; H Karibe; WD Rooney; G J Zarow; Steven H Graham; Michael Weiner; Philip R Weinstein
Correlation of early reduction in the apparent diffusion coefficient of water with blood flow reduction during middle cerebral artery occlusion in rats.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1995;34(3):368-77.
1995: J Chen; Philip R Weinstein; Steven H Graham
Attenuation of postischemic brain hypoperfusion and reperfusion injury by the cyclooxygenase-lipoxygenase inhibitor BW755C.
Journal of neurosurgery 1995;83(1):99-104.
1995: J Chen; Steven H Graham; Pak H Chan; J Lan; R L Zhou; Roger P. Simon
bcl-2 is expressed in neurons that survive focal ischemia in the rat.
Neuroreport 1995;6(2):394-8.
1995: J Chen; T Marsh; J S Zhang; Steven H Graham
Expression of cyclo-oxygenase 2 in rat brain following kainate treatment.
Neuroreport 1995;6(2):245-8.
1994: Raymond Swanson; Steven H Graham
Fluorocitrate and fluoroacetate effects on astrocyte metabolism in vitro.
Brain research 1994;664(1-2):94-100.
1994: H L Gaspary; Roger P. Simon; Steven H Graham
BW1003C87 and NBQX but not CGS19755 reduce glutamate release and cerebral ischemic necrosis.
European journal of pharmacology 1994;262(3):197-203.
1994: H Karibe; G J Zarow; Steven H Graham; Philip R Weinstein
Mild intraischemic hypothermia reduces postischemic hyperperfusion, delayed postischemic hypoperfusion, blood-brain barrier disruption, brain edema, and neuronal damage volume after temporary focal cerebral ischemia in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1994;14(4):620-7.
1994: H Karibe; S F Chen; G J Zarow; J Gafni; Steven H Graham; Pak H Chan; Philip R Weinstein
Mild intraischemic hypothermia suppresses consumption of endogenous antioxidants after temporary focal ischemia in rats.
Brain research 1994;649(1-2):12-8.
1994: T Ebisu; WD Rooney; Steven H Graham; Michael Weiner; Andrew A Maudsley
N-acetylaspartate as an in vivo marker of neuronal viability in kainate-induced status epilepticus: 1H magnetic resonance spectroscopic imaging.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1994;14(3):373-82.
1994: Steven H Graham; J Chen; J Lan; M J Leach; Roger P. Simon
Neuroprotective effects of a use-dependent blocker of voltage-dependent sodium channels, BW619C89, in rat middle cerebral artery occlusion.
The Journal of pharmacology and experimental therapeutics 1994;269(2):854-9.
1994: Steven H Graham; Dieter Meyerhoff; L Bayne; Frank R Sharp; Michael Weiner
Magnetic resonance spectroscopy of N-acetylaspartate in hypoxic-ischemic encephalopathy.
Annals of neurology 1994;35(4):490-4.
1994: H Karibe; J Chen; G J Zarow; Steven H Graham; Philip R Weinstein
Delayed induction of mild hypothermia to reduce infarct volume after temporary middle cerebral artery occlusion in rats.
Journal of neurosurgery 1994;80(1):112-9.
1994: Raymond Swanson; J Chen; Steven H Graham
Glucose can fuel glutamate uptake in ischemic brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1994;14(1):1-6.
1993: Steven H Graham; H Shimizu; A Newman; P Weinstein; Alan Faden
Opioid receptor antagonist nalmefene stereospecifically inhibits glutamate release during global cerebral ischemia.
Brain research 1993;632(1-2):346-50.
1993: S Wang; Frank M Longo; J Chen; M Butman; Steven H Graham; K G Haglid; Frank R Sharp
Induction of glucose regulated protein (grp78) and inducible heat shock protein (hsp70) mRNAs in rat brain after kainic acid seizures and focal ischemia.
Neurochemistry international 1993;23(6):575-82.
1993: Frank R Sharp; M Butman; S Wang; Jari Koistinaho; Steven H Graham; S M Sagar; P Berger; Frank M Longo
Heat shock proteins used to show that haloperidol prevents neuronal injury produced by ketamine, MK801, and phencyclidine.
Annals of the New York Academy of Sciences 1993;679():288-90.
1993: Roger P. Simon; J Chen; Steven H Graham
GM1 ganglioside treatment of focal ischemia: a dose-response and microdialysis study.
The Journal of pharmacology and experimental therapeutics 1993;265(1):24-9.
1993: H Shimizu; Steven H Graham; L H Chang; J Mintorovitch; Tom L James; Alan Faden; Philip R Weinstein
Relationship between extracellular neurotransmitter amino acids and energy metabolism during cerebral ischemia in rats monitored by microdialysis and in vivo magnetic resonance spectroscopy.
Brain research 1993;605(1):33-42.
1993: Steven H Graham; J Chen; Frank R Sharp; Roger P. Simon
Limiting ischemic injury by inhibition of excitatory amino acid release.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1993;13(1):88-97.
1992: Frank R Sharp; M Butman; S Wang; Jari Koistinaho; Steven H Graham; S M Sagar; Linda J Noble; P Berger; Frank M Longo
Haloperidol prevents induction of the hsp70 heat shock gene in neurons injured by phencyclidine (PCP), MK801, and ketamine.
Journal of neuroscience research 1992;33(4):605-16.
1992: Brian S Meldrum; J H Swan; M J Leach; M H Millan; R Gwinn; K Kadota; Steven H Graham; J Chen; Roger P. Simon
Reduction of glutamate release and protection against ischemic brain damage by BW 1003C87.
Brain research 1992;593(1):1-6.
1990: Steven H Graham; K Shiraishi; S Scott Panter; Roger P. Simon; Alan Faden
Changes in extracellular amino acid neurotransmitters produced by focal cerebral ischemia.
Neuroscience letters 1990;110(1-2):124-30.