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Edith Butler Gralla

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Yuewei Sheng; Diane E Cabelli; Duilio Cascio; Armando Durazo; Edith Butler Gralla; Mikhail Schumacher; Joan Selverstone Valentine
Tetramerization Reinforces the Dimer Interface of MnSOD.
Kevin Barnese; Edith Butler Gralla; Joan Selverstone Valentine; Diane E Cabelli
Biologically relevant mechanism for catalytic superoxide removal by simple manganese compounds.
Zrinka Rajic; Huaxin Sheng; Ivan Spasojevic; Artak Tovmasyan; David S Warner; Ludmil Benov; Edith Butler Gralla; Alice M Li; Miaomiao Lu; Ines Batinic-Haberle
A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity.

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2013: Yuewei Sheng; Diane E Cabelli; Duilio Cascio; Armando Durazo; Edith Butler Gralla; Mikhail Schumacher; Joan Selverstone Valentine
Tetramerization Reinforces the Dimer Interface of MnSOD.
PloS one 2013;8(5):e62446.
2012: Kevin Barnese; Edith Butler Gralla; Joan Selverstone Valentine; Diane E Cabelli
Biologically relevant mechanism for catalytic superoxide removal by simple manganese compounds.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(18):6892-7.
2012: Zrinka Rajic; Huaxin Sheng; Ivan Spasojevic; Artak Tovmasyan; David S Warner; Ludmil Benov; Edith Butler Gralla; Alice M Li; Miaomiao Lu; Ines Batinic-Haberle
A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity.
Free radical biology & medicine 2012;52(9):1828-34.
2011: Sadaf Sehati; Matthew H S Clement; Jake Martins; Lei Xu; Valter D Longo; Joan Selverstone Valentine; Edith Butler Gralla
Metabolic alterations in yeast lacking copper-zinc superoxide dismutase.
Free radical biology & medicine 2011;50(11):1591-8.
2011: Herman L Lelie; A Liba; Megan W Bourassa; Madhuri Chattopadhyay; Pik K Chan; Edith Butler Gralla; Lisa M Miller; David R Borchelt; Joan Selverstone Valentine; Julian P Whitelegge
Copper and zinc metallation status of copper-zinc superoxide dismutase from amyotrophic lateral sclerosis transgenic mice.
The Journal of biological chemistry 2011;286(4):2795-806.
2010: Kevin Barnese; Yuewei Sheng; Troy A Stich; Edith Butler Gralla; R David Britt; Diane E Cabelli; Joan Selverstone Valentine
Investigation of the highly active manganese superoxide dismutase from Saccharomyces cerevisiae.
Journal of the American Chemical Society 2010;132(36):12525-7.
2010: Rebecca L McNaughton; Amit R Reddi; Matthew H S Clement; Ajay Sharma; Kevin Barnese; Leah Rosenfeld; Edith Butler Gralla; Joan Selverstone Valentine; Valeria Cizewski Culotta; Brian M Hoffman
Probing in vivo Mn2+ speciation and oxidative stress resistance in yeast cells with electron-nuclear double resonance spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(35):15335-9.
2009: Julianne M Pollard; Julio S Reboucas; Armando Durazo; Ivan Kos; Francesca Fike; Moeen Panni; Edith Butler Gralla; Joan Selverstone Valentine; Ines Batinic-Haberle; Richard A Gatti
Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia-telangiectasia cells.
Free radical biology & medicine 2009;47(3):250-60.
2008: Joan Selverstone Valentine; Edith Butler Gralla
Reactive oxygen species special feature.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(24):8178.
2008: Kevin Barnese; Edith Butler Gralla; Diane E Cabelli; Joan Selverstone Valentine
Manganous phosphate acts as a superoxide dismutase.
Journal of the American Chemical Society 2008;130(14):4604-6.
2008: Bryan Francis Shaw; Herman L Lelie; Armando Durazo; Aram M Nersissian; Guilian Xu; Pik K Chan; Edith Butler Gralla; Ashutosh Tiwari; Lawrence J Hayward; David R Borchelt; Joan Selverstone Valentine; Julian P Whitelegge
Detergent-insoluble aggregates associated with amyotrophic lateral sclerosis in transgenic mice contain primarily full-length, unmodified superoxide dismutase-1.
The Journal of biological chemistry 2008;283(13):8340-50.
2007: William Munroe; Carolyn Kingsley; Armando Durazo; Edith Butler Gralla; James A Imlay; Chandra Srinivasan; Joan Selverstone Valentine
Only one of a wide assortment of manganese-containing SOD mimicking compounds rescues the slow aerobic growth phenotypes of both Escherichia coli and Saccharomyces cerevisiae strains lacking superoxide dismutase enzymes.
Journal of inorganic biochemistry 2007;101(11-12):1875-82.
2007: Lucia Banci; Ivano Bertini; Armando Durazo; Stefania Girotto; Edith Butler Gralla; Manuele Martinelli; Joan Selverstone Valentine; Miguela Vieru; Julian P Whitelegge
Metal-free superoxide dismutase forms soluble oligomers under physiological conditions: a possible general mechanism for familial ALS.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(27):11263-7.
2007: Soshanna Zittin Potter; Haining Zhu; Bryan Francis Shaw; Jorge A Rodriguez; Peter A Doucette; Se Hui Sohn; Armando Durazo; Kym F Faull; Edith Butler Gralla; Aram M Nersissian; Joan Selverstone Valentine
Binding of a single zinc ion to one subunit of copper-zinc superoxide dismutase apoprotein substantially influences the structure and stability of the entire homodimeric protein.
Journal of the American Chemical Society 2007;129(15):4575-83.
2006: Alberto Ferri; Mauro Cozzolino; Claudia Crosio; Monica Nencini; Arianna Casciati; Edith Butler Gralla; Giuseppe Rotilio; Joan Selverstone Valentine; Maria Teresa Carrì
Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(37):13860-5.
2006: Ruth Danzeisen; Tilmann Achsel; Ulrich Bederke; Mauro Cozzolino; Claudia Crosio; Alberto Ferri; Malte Frenzel; Edith Butler Gralla; Lea Huber; Albert C Ludolph; Monica Nencini; Giuseppe Rotilio; Joan Selverstone Valentine; Maria Teresa Carrì
Superoxide dismutase 1 modulates expression of transferrin receptor.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2006;11(4):489-98.
2005: Raylene J Sanchez; Chandra Srinivasan; William H Munroe; Matthew Alan Wallace; Jacob Martins; Tina Y Kao; Kate Le; Edith Butler Gralla; Joan Selverstone Valentine
Exogenous manganous ion at millimolar levels rescues all known dioxygen-sensitive phenotypes of yeast lacking CuZnSOD.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2005;10(8):913-23.
2005: Matthew Alan Wallace; Sasaneh Bailey; Jon M Fukuto; Joan Selverstone Valentine; Edith Butler Gralla
Induction of phenotypes resembling CuZn-superoxide dismutase deletion in wild-type yeast cells: an in vivo assay for the role of superoxide in the toxicity of redox-cycling compounds.
Chemical research in toxicology 2005;18(8):1279-86.
2005: Andrew Pelling; Sadaf Sehati; Edith Butler Gralla; James K Gimzewski
Time dependence of the frequency and amplitude of the local nanomechanical motion of yeast.
Nanomedicine : nanotechnology, biology, and medicine 2005;1(2):178-83.
2004: Paola Fabrizio; Luisa Battistella; Raffaello Vardavas; Cristina Gattazzo; Lee-Loung Liou; Alberto Diaspro; Janis W Dossen; Edith Butler Gralla; Valter D Longo
Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae.
The Journal of cell biology 2004;166(7):1055-67.
2004: Andrew Pelling; Sadaf Sehati; Edith Butler Gralla; Joan Selverstone Valentine; James K Gimzewski
Local nanomechanical motion of the cell wall of Saccharomyces cerevisiae.
Science (New York, N.Y.) 2004;305(5687):1147-50.
2004: Matthew Alan Wallace; Lee-Loung Liou; Jacob Martins; Matthew H S Clement; Sasaneh Bailey; Valter D Longo; Joan Selverstone Valentine; Edith Butler Gralla
Superoxide inhibits 4Fe-4S cluster enzymes involved in amino acid biosynthesis. Cross-compartment protection by CuZn-superoxide dismutase.
The Journal of biological chemistry 2004;279(31):32055-62.
2003: Paola Fabrizio; Lee-Loung Liou; Vanessa N Moy; Alberto Diaspro; Joan Selverstone Valentine; Edith Butler Gralla; Valter D Longo
SOD2 functions downstream of Sch9 to extend longevity in yeast.
Genetics 2003;163(1):35-46.
2002: James A Roe; Martina Wiedau-Pazos; Vanessa N Moy; Joy J Goto; Edith Butler Gralla; Joan Selverstone Valentine
In vivo peroxidative activity of FALS-mutant human CuZnSODs expressed in yeast.
Free radical biology & medicine 2002;32(2):169-74.
2002: Chandra Srinivasan; Edith Butler Gralla
Measurement of "free" or electron paramagnetic resonance-detectable iron in whole yeast cells as indicator of superoxide stress.
Methods in enzymology 2002;349():173-80.
2001: J P Wei; Chandra Srinivasan; H Han; Joan Selverstone Valentine; Edith Butler Gralla
Evidence for a novel role of copper-zinc superoxide dismutase in zinc metabolism.
The Journal of biological chemistry 2001;276(48):44798-803.
2000: Chandra Srinivasan; A Liba; James A Imlay; Joan Selverstone Valentine; Edith Butler Gralla
Yeast lacking superoxide dismutase(s) show elevated levels of "free iron" as measured by whole cell electron paramagnetic resonance.
The Journal of biological chemistry 2000;275(38):29187-92.
2000: H Liu; Haining Zhu; Daryl K Eggers; Aram M Nersissian; Kym F Faull; JJ Goto; Jingyuan Ai; Joann Sanders-Loehr; Edith Butler Gralla; Joan Selverstone Valentine
Copper(2+) binding to the surface residue cysteine 111 of His46Arg human copper-zinc superoxide dismutase, a familial amyotrophic lateral sclerosis mutant.
Biochemistry 2000;39(28):8125-32.
2000: KT Chiang; masaru shinyashiki; Christopher H Switzer; Joan Selverstone Valentine; Edith Butler Gralla; D J Thiele; Jon M Fukuto
Effects of nitric oxide on the copper-responsive transcription factor Ace1 in Saccharomyces cerevisiae: cytotoxic and cytoprotective actions of nitric oxide.
Archives of biochemistry and biophysics 2000;377(2):296-303.
2000: Haining Zhu; Eric L Shipp; Raylene J Sanchez; A Liba; J E Stine; Peter Hart; Edith Butler Gralla; Aram M Nersissian; Joan Selverstone Valentine
Cobalt(2+) binding to human and tomato copper chaperone for superoxide dismutase: implications for the metal ion transfer mechanism.
Biochemistry 2000;39(18):5413-21.
2000: J M De Freitas; A Liba; Rogério Meneghini; Joan Selverstone Valentine; Edith Butler Gralla
Yeast lacking Cu-Zn superoxide dismutase show altered iron homeostasis. Role of oxidative stress in iron metabolism.
The Journal of biological chemistry 2000;275(16):11645-9.
2000: T J Lyons; Aram M Nersissian; H Huang; H Yeom; C R Nishida; J A Graden; Edith Butler Gralla; Joan Selverstone Valentine
The metal binding properties of the zinc site of yeast copper-zinc superoxide dismutase: implications for amyotrophic lateral sclerosis.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2000;5(2):189-203.
2000: masaru shinyashiki; KT Chiang; Christopher H Switzer; Edith Butler Gralla; Joan Selverstone Valentine; D J Thiele; Jon M Fukuto
The interaction of nitric oxide (NO) with the yeast transcription factor Ace1: A model system for NO-protein thiol interactions with implications to metal metabolism.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2491-6.
2000: JJ Goto; Haining Zhu; Raylene J Sanchez; Aram M Nersissian; Edith Butler Gralla; Joan Selverstone Valentine; Diane E Cabelli
Loss of in vitro metal ion binding specificity in mutant copper-zinc superoxide dismutases associated with familial amyotrophic lateral sclerosis.
The Journal of biological chemistry 2000;275(2):1007-14.
1999: Valter D Longo; Lee-Loung Liou; Joan Selverstone Valentine; Edith Butler Gralla
Mitochondrial superoxide decreases yeast survival in stationary phase.
Archives of biochemistry and biophysics 1999;365(1):131-42.
1999: T J Lyons; Edith Butler Gralla; Joan Selverstone Valentine
Biological chemistry of copper-zinc superoxide dismutase and its link to amyotrophic lateral sclerosis.
Metal ions in biological systems 1999;36():125-77.
1999: Joan Selverstone Valentine; Peter Hart; Edith Butler Gralla
Copper-zinc superoxide dismutase and ALS.
Advances in experimental medicine and biology 1999;448():193-203.
1998: JJ Goto; Edith Butler Gralla; Joan Selverstone Valentine; Diane E Cabelli
Reactions of hydrogen peroxide with familial amyotrophic lateral sclerosis mutant human copper-zinc superoxide dismutases studied by pulse radiolysis.
The Journal of biological chemistry 1998;273(46):30104-9.
1998: Joan Selverstone Valentine; D L Wertz; T J Lyons; Lee-Loung Liou; J J Goto; Edith Butler Gralla
The dark side of dioxygen biochemistry.
Current opinion in chemical biology 1998;2(2):253-62.
1998: Peter Hart; H Liu; M Pellegrini; Aram M Nersissian; Edith Butler Gralla; Joan Selverstone Valentine; David Eisenberg
Subunit asymmetry in the three-dimensional structure of a human CuZnSOD mutant found in familial amyotrophic lateral sclerosis.
Protein science : a publication of the Protein Society 1998;7(3):545-55.
1997: Joan Selverstone Valentine; Edith Butler Gralla
Delivering copper inside yeast and human cells.
Science (New York, N.Y.) 1997;278(5339):817-8.
1997: Valter D Longo; Lisa M Ellerby; Dale E Bredesen; Joan Selverstone Valentine; Edith Butler Gralla
Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast.
The Journal of cell biology 1997;137(7):1581-8.
1996: T J Lyons; Hantao Liu; J J Goto; Aram M Nersissian; J A Roe; J A Graden; C Café; Lisa M Ellerby; Dale E Bredesen; Edith Butler Gralla; Joan Selverstone Valentine
Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(22):12240-4.
1996: Dale E Bredesen; M Wiedau-Pazos; J J Goto; Shahrooz Rabizadeh; J A Roe; Edith Butler Gralla; Lisa M Ellerby; Joan Selverstone Valentine
Cell death mechanisms in ALS.
Neurology 1996;47(4 Suppl 2):S36-8; discussion S38-9.
1996: J R Schultz; Lisa M Ellerby; Edith Butler Gralla; Joan Selverstone Valentine; Catherine F Clarke
Autoxidation of ubiquinol-6 is independent of superoxide dismutase.
Biochemistry 1996;35(21):6595-603.
1996: Valter D Longo; Edith Butler Gralla; Joan Selverstone Valentine
Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo.
The Journal of biological chemistry 1996;271(21):12275-80.
1996: M Wiedau-Pazos; J J Goto; Shahrooz Rabizadeh; Edith Butler Gralla; J A Roe; Michael K Lee; Joan Selverstone Valentine; Dale E Bredesen
Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis.
Science (New York, N.Y.) 1996;271(5248):515-8.
1995: Shahrooz Rabizadeh; Edith Butler Gralla; David R Borchelt; R Gwinn; Joan Selverstone Valentine; Sangram S Sisodia; Philip C Wong; Michael K Lee; H Hahn; Dale E Bredesen
Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):3024-8.
1994: C R Nishida; Edith Butler Gralla; Joan Selverstone Valentine
Characterization of three yeast copper-zinc superoxide dismutase mutants analogous to those coded for in familial amyotrophic lateral sclerosis.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(21):9906-10.
1993: D J Kane; Theodore A Sarafian; R Anton; H Hahn; Edith Butler Gralla; Joan Selverstone Valentine; T Ord; Dale E Bredesen
Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species.
Science (New York, N.Y.) 1993;262(5137):1274-7.
1993: K T Tamai; Edith Butler Gralla; Lisa M Ellerby; Joan Selverstone Valentine; Dennis J Thiele
Yeast and mammalian metallothioneins functionally substitute for yeast copper-zinc superoxide dismutase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(17):8013-7.
1992: XF Liu; I Elashvili; Edith Butler Gralla; Joan Selverstone Valentine; P Lapinskas; Valeria Cizewski Culotta
Yeast lacking superoxide dismutase. Isolation of genetic suppressors.
The Journal of biological chemistry 1992;267(26):18298-302.
1992: Edith Butler Gralla; Daniel J Kosman
Molecular genetics of superoxide dismutases in yeasts and related fungi.
Advances in genetics 1992;30():251-319.
1991: Edith Butler Gralla; Dennis J Thiele; P Silar; Joan Selverstone Valentine
ACE1, a copper-dependent transcription factor, activates expression of the yeast copper, zinc superoxide dismutase gene.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8558-62.
1991: Edith Butler Gralla; Joan Selverstone Valentine
Null mutants of Saccharomyces cerevisiae Cu,Zn superoxide dismutase: characterization and spontaneous mutation rates.
Journal of bacteriology 1991;173(18):5918-20.
1988: O Bermingham-McDonogh; Edith Butler Gralla; Joan Selverstone Valentine
The copper, zinc-superoxide dismutase gene of Saccharomyces cerevisiae: cloning, sequencing, and biological activity.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(13):4789-93.