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Jay Gralla

Research Profile

Physiology

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Publications

TOP 3
Khiem Tran; Jay D Gralla
The TFIIB tip domain couples transcription initiation to events involved in RNA processing.
Jay D Gralla; Yi-Xin Huo
Remodeling and activation of Escherichia coli RNA polymerase by osmolytes.
Yi-Xin Huo; Adam Z Rosenthal; Jay D Gralla
General stress response signalling: unwrapping transcription complexes by DNA relaxation via the sigma38 C-terminal domain.

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All Publications

2010: Khiem Tran; Jay D Gralla
The TFIIB tip domain couples transcription initiation to events involved in RNA processing.
The Journal of biological chemistry 2010;285(51):39580-7.
2008: Jay D Gralla; Yi-Xin Huo
Remodeling and activation of Escherichia coli RNA polymerase by osmolytes.
Biochemistry 2008;47(50):13189-96.
2008: Yi-Xin Huo; Adam Z Rosenthal; Jay D Gralla
General stress response signalling: unwrapping transcription complexes by DNA relaxation via the sigma38 C-terminal domain.
Molecular microbiology 2008;70(2):369-78.
2008: Khiem Tran; Jay D Gralla
Control of the timing of promoter escape and RNA catalysis by the transcription factor IIb fingertip.
The Journal of biological chemistry 2008;283(23):15665-71.
2008: Adam Z Rosenthal; Youngbae Kim; Jay D Gralla
Regulation of transcription by acetate in Escherichia coli: in vivo and in vitro comparisons.
Molecular microbiology 2008;68(4):907-17.
2008: Adam Z Rosenthal; Youngbae Kim; Jay D Gralla
Poising of Escherichia coli RNA polymerase and its release from the sigma 38 C-terminal tail for osmY transcription.
Journal of molecular biology 2008;376(4):938-49.
2006: Youngbae Kim; Chih M Lew; Jay D Gralla
Escherichia coli pfs transcription: regulation and proposed roles in autoinducer-2 synthesis and purine excretion.
Journal of bacteriology 2006;188(21):7457-63.
2006: Jay D Gralla; David R Vargas
Potassium glutamate as a transcriptional inhibitor during bacterial osmoregulation.
The EMBO journal 2006;25(7):1515-21.
2006: Adam Z Rosenthal; Minshan Hu; Jay D Gralla
Osmolyte-induced transcription: -35 region elements and recognition by sigma38 (rpoS).
Molecular microbiology 2006;59(3):1052-61.
2005: Yin Chun Lin; Wai S Choi; Jay D Gralla
TFIIH XPB mutants suggest a unified bacterial-like mechanism for promoter opening but not escape.
Nature structural & molecular biology 2005;12(7):603-7.
2005: Jay D Gralla
Escherichia coli ribosomal RNA transcription: regulatory roles for ppGpp, NTPs, architectural proteins and a polymerase-binding protein.
Molecular microbiology 2005;55(4):973-7.
2004: Chih M Lew; Jay D Gralla
Nucleotide-dependent isomerization of Escherichia coli RNA polymerase.
Biochemistry 2004;43(39):12660-6.
2004: Wai S Choi; Yin C Lin; Jay D Gralla
The Schizosaccharomyces pombe open promoter bubble: mammalian-like arrangement and properties.
Journal of molecular biology 2004;340(5):981-9.
2004: Chih M Lew; Jay D Gralla
Mechanism of stimulation of ribosomal promoters by binding of the +1 and +2 nucleotides.
The Journal of biological chemistry 2004;279(19):19481-5.
2004: Shun Jin Lee; Jay D Gralla
Osmo-regulation of bacterial transcription via poised RNA polymerase.
Molecular cell 2004;14(2):153-62.
2003: Mike S Fenton; Jay D Gralla
Roles for inhibitory interactions in the use of the -10 promoter element by sigma 70 holoenzyme.
The Journal of biological chemistry 2003;278(41):39669-74.
2003: Shun Jin Lee; Jay D Gralla
Open complex formation in vitro by sigma38 (rpoS) RNA polymerase: roles for region 2 amino acids.
Journal of molecular biology 2003;329(5):941-8.
2003: Mike S Fenton; Jay D Gralla
Effect of DNA bases and backbone on sigma70 holoenzyme binding and isomerization using fork junction probes.
Nucleic acids research 2003;31(11):2745-50.
2002: Shun Jin Lee; Jay D Gralla
Promoter use by sigma 38 (rpoS) RNA polymerase. Amino acid clusters for DNA binding and isomerization.
The Journal of biological chemistry 2002;277(49):47420-7.
2002: Chih M Lew; Jay D Gralla
New roles for conserved regions within a sigma 54-dependent enhancer-binding protein.
The Journal of biological chemistry 2002;277(44):41517-24.
2002: Wai S Choi; Ming Yan; Dmitri Nusinow; Jay D Gralla
In vitro transcription and start site selection in Schizosaccharomyces pombe.
Journal of molecular biology 2002;319(5):1005-13.
2001: Shun Jin Lee; Jay D Gralla
Sigma38 (rpoS) RNA polymerase promoter engagement via -10 region nucleotides.
The Journal of biological chemistry 2001;276(32):30064-71.
2001: Mike S Fenton; Jay D Gralla
Function of the bacterial TATAAT -10 element as single-stranded DNA during RNA polymerase isomerization.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):9020-5.
2001: L Wang; Jay D Gralla
Roles for the C-terminal region of sigma 54 in transcriptional silencing and DNA binding.
The Journal of biological chemistry 2001;276(12):8979-86.
2001: Branden Wolner; Jay D Gralla
TATA-flanking sequences influence the rate and stability of TATA-binding protein and TFIIB binding.
The Journal of biological chemistry 2001;276(9):6260-6.
2000: Yunbo Guo; Chih M Lew; Jay D Gralla
Promoter opening by sigma(54) and sigma(70) RNA polymerases: sigma factor-directed alterations in the mechanism and tightness of control.
Genes & development 2000;14(17):2242-55.
2000: Branden Wolner; Jay D Gralla
Roles for non-TATA core promoter sequences in transcription and factor binding.
Molecular and cellular biology 2000;20(10):3608-15.
2000: Mike S Fenton; Shun Jin Lee; Jay D Gralla
Escherichia coli promoter opening and -10 recognition: mutational analysis of sigma70.
The EMBO journal 2000;19(5):1130-7.
1999: Ming Yan; Jay D Gralla
The use of ATP and initiating nucleotides during postrecruitment steps at the activated adenovirus E4 promoter.
The Journal of biological chemistry 1999;274(49):34819-24.
1999: L Wang; Yunbo Guo; Jay D Gralla
Regulation of sigma 54-dependent transcription by core promoter sequences: role of -12 region nucleotides.
Journal of bacteriology 1999;181(24):7558-65.
1999: Yunbo Guo; L Wang; Jay D Gralla
A fork junction DNA-protein switch that controls promoter melting by the bacterial enhancer-dependent sigma factor.
The EMBO journal 1999;18(13):3736-45.
1999: D Yean; Jay D Gralla
Transcription reinitiation rate: a potential role for TATA box stabilization of the TFIID:TFIIA:DNA complex.
Nucleic acids research 1999;27(3):831-8.
1998: L Wang; Jay D Gralla
Multiple in vivo roles for the -12-region elements of sigma 54 promoters.
Journal of bacteriology 1998;180(21):5626-31.
1998: A Syed; Jay D Gralla
Identification of an N-terminal region of sigma 54 required for enhancer responsiveness.
Journal of bacteriology 1998;180(21):5619-25.
1998: Yunbo Guo; Jay D Gralla
Promoter opening via a DNA fork junction binding activity.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11655-60.
1997: Branden Wolner; Jay D Gralla
Promoter activation via a cyclic AMP response element in vitro.
The Journal of biological chemistry 1997;272(51):32301-7.
1997: Ming Yan; Jay D Gralla
Multiple ATP-dependent steps in RNA polymerase II promoter melting and initiation.
The EMBO journal 1997;16(24):7457-67.
1997: J T Wang; A Syed; Jay D Gralla
Multiple pathways to bypass the enhancer requirement of sigma 54 RNA polymerase: roles for DNA and protein determinants.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(18):9538-43.
1997: D Yean; Jay D Gralla
Transcription reinitiation rate: a special role for the TATA box.
Molecular and cellular biology 1997;17(7):3809-16.
1997: A Syed; Jay D Gralla
Isolation and properties of enhancer-bypass mutants of sigma 54.
Molecular microbiology 1997;23(5):987-95.
1997: Yunbo Guo; Jay D Gralla
DNA-binding determinants of sigma 54 as deduced from libraries of mutations.
Journal of bacteriology 1997;179(4):1239-45.
1996: J T Wang; Jay D Gralla
The transcription initiation pathway of sigma 54 mutants that bypass the enhancer protein requirement. Implications for the mechanism of activation.
The Journal of biological chemistry 1996;271(51):32707-13.
1996: D Yean; Jay D Gralla
Transcription activation by GC-boxes: evaluation of kinetic and equilibrium contributions.
Nucleic acids research 1996;24(14):2723-9.
1996: Y Jiang; M Yan; Jay D Gralla
A three-step pathway of transcription initiation leading to promoter clearance at an activation RNA polymerase II promoter.
Molecular and cellular biology 1996;16(4):1614-21.
1996: Jay D Gralla
Global steps during initiation by RNA polymerase II.
Methods in enzymology 1996;273():99-110.
1995: Y Jiang; M Yan; Jay D Gralla
Abortive initiation and first bond formation at an activated adenovirus E4 promoter.
The Journal of biological chemistry 1995;270(45):27332-8.
1995: J T Wang; A Syed; M Hsieh; Jay D Gralla
Converting Escherichia coli RNA polymerase into an enhancer-responsive enzyme: role of an NH2-terminal leucine patch in sigma 54.
Science (New York, N.Y.) 1995;270(5238):992-4.
1995: Yin Tintut; J T Wang; Jay D Gralla
Abortive cycling and the release of polymerase for elongation at the sigma 54-dependent glnAp2 promoter.
The Journal of biological chemistry 1995;270(41):24392-8.
1995: Yin Tintut; Jay D Gralla
PCR mutagenesis identifies a polymerase-binding sequence of sigma 54 that includes a sigma 70 homology region.
Journal of bacteriology 1995;177(20):5818-25.
1995: Yin Tintut; J T Wang; Jay D Gralla
A novel bacterial transcription cycle involving sigma 54.
Genes & development 1995;9(18):2305-13.
1995: Y Jiang; Jay D Gralla
Nucleotide requirements for activated RNA polymerase II open complex formation in vitro.
The Journal of biological chemistry 1995;270(3):1277-81.
1994: Y Jiang; Jay D Gralla
RNA polymerase II phosphorylation: uncoupling from GAL4-VP16 directed open complex formation and transcription in a reconstituted system.
Nucleic acids research 1994;22(23):4958-62.
1994: C Chang; Jay D Gralla
A critical role for chromatin in mounting a synergistic transcriptional response to GAL4-VP16.
Molecular and cellular biology 1994;14(8):5175-81.
1994: M Hsieh; Jay D Gralla
Analysis of the N-terminal leucine heptad and hexad repeats of sigma 54.
Journal of molecular biology 1994;239(1):15-24.
1994: Yin Tintut; C Wong; Y Jiang; M Hsieh; Jay D Gralla
RNA polymerase binding using a strongly acidic hydrophobic-repeat region of sigma 54.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(6):2120-4.
1994: Y Jiang; Steven J Triezenberg; Jay D Gralla
Defective transcriptional activation by diverse VP16 mutants associated with a common inability to form open promoter complexes.
The Journal of biological chemistry 1994;269(8):5505-8.
1994: C Wong; Yin Tintut; Jay D Gralla
The domain structure of sigma 54 as determined by analysis of a set of deletion mutants.
Journal of molecular biology 1994;236(1):81-90.
1994: M Hsieh; Yin Tintut; Jay D Gralla
Functional roles for the glutamines within the glutamine-rich region of the transcription factor sigma 54.
The Journal of biological chemistry 1994;269(1):373-8.
1993: C Chang; Jay D Gralla
Properties of initiator-associated transcription mediated by GAL4-VP16.
Molecular and cellular biology 1993;13(12):7469-75.
1993: Y Jiang; Jay D Gralla
Uncoupling of initiation and reinitiation rates during HeLa RNA polymerase II transcription in vitro.
Molecular and cellular biology 1993;13(8):4572-7.
1993: Y Jiang; Stephen T Smale; Jay D Gralla
A common ATP requirement for open complex formation and transcription at promoters containing initiator or TATA elements.
The Journal of biological chemistry 1993;268(9):6535-40.
1993: Jay D Gralla
Opening promoters for m-RNA transcription.
Cellular & molecular biology research 1993;39(4):319-22.
1992: C Wong; Jay D Gralla
A role for the acidic trimer repeat region of transcription factor sigma 54 in setting the rate and temperature dependence of promoter melting in vivo.
The Journal of biological chemistry 1992;267(34):24762-8.
1992: K L Ohlsen; Jay D Gralla
DNA melting within stable closed complexes at the Escherichia coli rrnB P1 promoter.
The Journal of biological chemistry 1992;267(28):19813-8.
1992: K L Ohlsen; Jay D Gralla
Melting during steady-state transcription of the rrnB P1 promoter in vivo and in vitro.
Journal of bacteriology 1992;174(19):6071-5.
1992: W Wang; Jay D Gralla; Michael Carey
The acidic activator GAL4-AH can stimulate polymerase II transcription by promoting assembly of a closed complex requiring TFIID and TFIIA.
Genes & development 1992;6(9):1716-27.
1992: K L Ohlsen; Jay D Gralla
Interrelated effects of DNA supercoiling, ppGpp, and low salt on melting within the Escherichia coli ribosomal RNA rrnB P1 promoter.
Molecular microbiology 1992;6(16):2243-51.
1992: A T Hoang; W Wang; Jay D Gralla
The replication activation potential of selected RNA polymerase II promoter elements at the simian virus 40 origin.
Molecular and cellular biology 1992;12(7):3087-93.
1992: G L Evans; Jay D Gralla
Cisplatin-induced imbalances in the pattern of chimeric marker gene expression in HeLa cells.
Biochemical and biophysical research communications 1992;184(1):1-8.
1992: W Wang; Michael Carey; Jay D Gralla
Polymerase II promoter activation: closed complex formation and ATP-driven start site opening.
Science (New York, N.Y.) 1992;255(5043):450-3.
1991: W D Wang; Jay D Gralla
Differential ability of proximal and remote element pairs to cooperate in activating RNA polymerase II transcription.
Molecular and cellular biology 1991;11(9):4561-71.
1991: Jay D Gralla
Transcriptional control--lessons from an E. coli promoter data base.
Cell 1991;66(3):415-8.
1991: S Sasse-Dwight; Jay D Gralla
Footprinting protein-DNA complexes in vivo.
Methods in enzymology 1991;208():146-68.
1990: S Sasse-Dwight; Jay D Gralla
Role of eukaryotic-type functional domains found in the prokaryotic enhancer receptor factor sigma 54.
Cell 1990;62(5):945-54.
1990: L Zhang; Jay D Gralla
In situ nucleoprotein structure involving origin-proximal SV40 DNA control elements.
Nucleic acids research 1990;18(7):1797-803.
1990: R L Buchanan; Jay D Gralla
Cisplatin resistance and mechanism in a viral test system: SV40 isolates that resist inhibition by the antitumor drug have lost regulatory DNA.
Biochemistry 1990;29(14):3436-42.
1990: R L Buchanan; Jay D Gralla
Programmed factor binding to simian virus 40 GC-box replication and transcription control sequences.
Journal of virology 1990;64(1):347-53.
1989: L Zhang; Jay D Gralla
In situ nucleoprotein structure at the SV40 major late promoter: melted and wrapped DNA flank the start site.
Genes & development 1989;3(11):1814-22.
1989: L Zhang; Jay D Gralla
Micrococcal nuclease as a probe for bound and distorted DNA in lac transcription and repression complexes.
Nucleic acids research 1989;17(13):5017-28.
1989: A L Meiklejohn; Jay D Gralla
Activation of the lac promoter and its variants. Synergistic effects of catabolite activator protein and supercoiling in vitro.
Journal of molecular biology 1989;207(4):661-73.
1989: S Sasse-Dwight; Jay D Gralla
KMnO4 as a probe for lac promoter DNA melting and mechanism in vivo.
The Journal of biological chemistry 1989;264(14):8074-81.
1989: Jay D Gralla
Bacterial gene regulation from distant DNA sites.
Cell 1989;57(2):193-5.
1988: Y Flashner; Jay D Gralla
Dual mechanism of repression at a distance in the lac operon.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):8968-72.
1988: S Sasse-Dwight; Jay D Gralla
Probing the Escherichia coli glnALG upstream activation mechanism in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):8934-8.
1988: Y Flashner; Jay D Gralla
DNA dynamic flexibility and protein recognition: differential stimulation by bacterial histone-like protein HU.
Cell 1988;54(5):713-21.
1988: S Sasse-Dwight; Jay D Gralla
Probing co-operative DNA-binding in vivo. The lac O1:O3 interaction.
Journal of molecular biology 1988;202(1):107-19.
1987: V L Balke; Jay D Gralla
Changes in the linking number of supercoiled DNA accompany growth transitions in Escherichia coli.
Journal of bacteriology 1987;169(10):4499-506.
1987: Jay D Gralla; S Sasse-Dwight; L G Poljak
Formation of blocking lesions at identical DNA sequences by the nitrosourea and platinum classes of anticancer drugs.
Cancer research 1987;47(19):5092-6.
1987: L G Poljak; Jay D Gralla
The SV40 termination region exhibits an altered helical DNA conformation.
Nucleic acids research 1987;15(13):5433-42.
1987: J A Borowiec; L Zhang; S Sasse-Dwight; Jay D Gralla
DNA supercoiling promotes formation of a bent repression loop in lac DNA.
Journal of molecular biology 1987;196(1):101-11.
1987: J A Borowiec; Jay D Gralla
All three elements of the lac ps promoter mediate its transcriptional response to DNA supercoiling.
Journal of molecular biology 1987;195(1):89-97.
1987: L G Poljak; Jay D Gralla
Competition for formation of nucleosomes on fragmented SV40 DNA: a hyperstable nucleosome forms on the termination region.
Biochemistry 1987;26(1):295-303.