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Hermann Gram

Research Profile

Chemicals & Drugs

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Mouse
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Publications

TOP 3
Abhijit Chakraborty; David Floch; Hermann Gram; Philip J Lowe; Christiane Rordorf; Stacey Tannenbaum; Sandip Roy
Pharmacokinetic and pharmacodynamic properties of canakinumab, a human anti-interleukin-1β monoclonal antibody.
Fredrik Clausen; Ted Ebendal; Hermann Gram; Anders Hånell; Johanna Hedin; Charlotte Israelsson; Anis K Mir; Niklas Marklund
Neutralization of interleukin-1β reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice.
Magdalena Koziczak-Holbro; Amanda Littlewood-Evans; Bernadette Pöllinger; Jiri Kovarik; Janet Dawson; Gerhard Zenke; Christoph Burkhart; Matthias Müller; Hermann Gram
The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation.

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All Publications

2012: Abhijit Chakraborty; David Floch; Hermann Gram; Philip J Lowe; Christiane Rordorf; Stacey Tannenbaum; Sandip Roy
Pharmacokinetic and pharmacodynamic properties of canakinumab, a human anti-interleukin-1β monoclonal antibody.
Clinical pharmacokinetics 2012;51(6):e1-18.
2011: Fredrik Clausen; Ted Ebendal; Hermann Gram; Anders Hånell; Johanna Hedin; Charlotte Israelsson; Anis K Mir; Niklas Marklund
Neutralization of interleukin-1β reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice.
The European journal of neuroscience 2011;34(1):110-23.
2009: Magdalena Koziczak-Holbro; Amanda Littlewood-Evans; Bernadette Pöllinger; Jiri Kovarik; Janet Dawson; Gerhard Zenke; Christoph Burkhart; Matthias Müller; Hermann Gram
The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation.
Arthritis and rheumatism 2009;60(6):1661-71.
2008: O Osborn; S E Brownell; Manuel Sanchez-Alavez; D Salomon; Hermann Gram; Tamas Bartfai
Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity.
Cytokine 2008;44(1):141-8.
2008: Magdalena Koziczak-Holbro; Anton Glück; Claude Tschopp; John C Mathison; Hermann Gram
IRAK-4 kinase activity-dependent and -independent regulation of lipopolysaccharide-inducible genes.
European journal of immunology 2008;38(3):788-96.
2007: Magdalena Koziczak-Holbro; Claire Joyce; Anton Glück; Bernd Kinzel; Matthias Müller; Claude Tschopp; John C Mathison; Christopher N Davis; Hermann Gram
IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression.
The Journal of biological chemistry 2007;282(18):13552-60.
2007: M Koziczak-Holbro; C Joyce; A Glück; B Kinzel; Matthias Müller; Hermann Gram
Solving the IRAK-4 enigma: application of kinase-dead knock-in mice.
Ernst Schering Foundation symposium proceedings 2007;(3):63-82.
2006: Laszlo Revesz; Ernst Blum; Franco E Di Padova; Thomas Buhl; Roland Feifel; Hermann Gram; Peter Hiestand; Ute Manning; Ulf Neumann; Gerard Rucklin
Pyrazoloheteroaryls: novel p38alpha MAP kinase inhibiting scaffolds with oral activity.
Bioorganic & medicinal chemistry letters 2006;16(2):262-6.
2005: Marije I Koenders; Erik Lubberts; Birgitte Oppers-Walgreen; Liduine Van Den Bersselaar; Monique M A Helsen; Franco E Di Padova; Mieke Boots; Hermann Gram; Leo A B Joosten; Wim B van den Berg
Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1.
The American journal of pathology 2005;167(1):141-9.
2005: Qing Jing; Shuang Huang; Sabine Guth; Tyler Zarubin; Andrea Motoyama; Jianming Chen; Franco E Di Padova; Sheng-Cai Lin; Hermann Gram; Jiahuai Han
Involvement of microRNA in AU-rich element-mediated mRNA instability.
Cell 2005;120(5):623-34.
2004: Laszlo Revesz; Ernst Blum; Franco E Di Padova; Thomas Buhl; Roland Feifel; Hermann Gram; Peter Hiestand; Ute Manning; Gerard Rucklin
SAR of benzoylpyridines and benzophenones as p38alpha MAP kinase inhibitors with oral activity.
Bioorganic & medicinal chemistry letters 2004;14(13):3601-5.
2004: Laszlo Revesz; Ernst Blum; Franco E Di Padova; Thomas Buhl; Roland Feifel; Hermann Gram; Peter Hiestand; Ute Manning; Gerard Rucklin
Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis.
Bioorganic & medicinal chemistry letters 2004;14(13):3595-9.
2004: Walter Schuler; Marc Bigaud; Volker Brinkmann; Franco E Di Padova; Sabine Geisse; Hermann Gram; Valerie Hungerford; Beate Kleuser; Colette Kristofic; Klaus Menninger; Reet Tees; Grazyna Wieczorek; Corinne Wilt; Catherine Wioland; Mauro Zurini
Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation.
Transplantation 2004;77(5):717-26.
2002: Laszlo Revesz; Franco E Di Padova; Thomas Buhl; Roland Feifel; Hermann Gram; Peter Hiestand; Ute Manning; Romain Wolf; Alfred G Zimmerlin
SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(16):2109-12.
2002: Baoxue Ge; Hermann Gram; Franco E Di Padova; Betty Huang; Liguo New; Richard J Ulevitch; Ying Luo; Jiahuai Han
MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.
Science (New York, N.Y.) 2002;295(5558):1291-4.
2001: U Knauf; Claude Tschopp; Hermann Gram
Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2.
Molecular and cellular biology 2001;21(16):5500-11.
2001: W Zhu; MA Brauchle; Franco E Di Padova; Hermann Gram; Liguo New; Koh Ono; JS Downey; Jiahuai Han
Gene suppression by tristetraprolin and release by the p38 pathway.
American journal of physiology. Lung cellular and molecular physiology 2001;281(2):L499-508.
2000: MA Brauchle; D Glück; Franco E Di Padova; Jiahuai Han; Hermann Gram
Independent role of p38 and ERK1/2 mitogen-activated kinases in the upregulation of matrix metalloproteinase-1.
Experimental cell research 2000;258(1):135-44.
2000: W Zhu; JS Downey; J Gu; Franco E Di Padova; Hermann Gram; Jiahuai Han
Regulation of TNF expression by multiple mitogen-activated protein kinase pathways.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6349-58.
2000: Laszlo Revesz; Franco E Di Padova; Thomas Buhl; Roland Feifel; Hermann Gram; Peter Hiestand; Ute Manning; Alfred G Zimmerlin
SAR of 4-hydroxypiperidine and hydroxyalkyl substituted heterocycles as novel p38 map kinase inhibitors.
Bioorganic & medicinal chemistry letters 2000;10(11):1261-4.
2000: Colleen Fearns; Lawrence E Kline; Hermann Gram; Franco E Di Padova; Mauro Zurini; Jiahuai Han; Richard J Ulevitch
Coordinate activation of endogenous p38alpha, beta, gamma, and delta by inflammatory stimuli.
Journal of leukocyte biology 2000;67(5):705-11.
2000: Claude Tschopp; U Knauf; MA Brauchle; Mauro Zurini; Paul Ramage; D Glueck; Liguo New; Jiahuai Han; Hermann Gram
Phosphorylation of eIF-4E on Ser 209 in response to mitogenic and inflammatory stimuli is faithfully detected by specific antibodies.
Molecular cell biology research communications : MCBRC 2000;3(4):205-211.
1999: Liguo New; M Zhao; Yiming Li; W W Bassett; Y Feng; S Ludwig; F D Padova; Hermann Gram; Jiahuai Han
Cloning and characterization of RLPK, a novel RSK-related protein kinase.
The Journal of biological chemistry 1999;274(2):1026-32.
1999: M Zhao; Liguo New; Vladimir V Kravchenko; Y Kato; Hermann Gram; Franco E Di Padova; E N Olson; Richard J Ulevitch; Jiahuai Han
Regulation of the MEF2 family of transcription factors by p38.
Molecular and cellular biology 1999;19(1):21-30.
1997: Yong Jiang; Hermann Gram; M Zhao; Liguo New; J Gu; L Feng; Franco E Di Padova; Richard J Ulevitch; Jiahuai Han
Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta.
The Journal of biological chemistry 1997;272(48):30122-8.