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Francis Grand

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Thomas Ernst; Joannah Score; Michael Deininger; Claire Hidalgo-Curtis; Peter Lackie; William B Ershler; John M Goldman; Nicholas C P Cross; Francis H Grand
Identification of FOXP1 and SNX2 as novel ABL1 fusion partners in acute lymphoblastic leukaemia.
Joannah Score; María J Calasanz; O Ottman; F Pane; R F Yeh; M A Sobrinho-Simões; Sebastian Kreil; D Ward; C Hidalgo-Curtis; Junia V Melo; J Wiemels; B Nadel; Nicholas C P Cross; Francis H Grand
Analysis of genomic breakpoints in p190 and p210 BCR-ABL indicate distinct mechanisms of formation.
Thomas Ernst; Andrew Chase; Katerina Zoi; Katherine Waghorn; Claire Hidalgo-Curtis; Joannah Score; Amy Jones; Francis H Grand; Andreas Reiter; Andreas Hochhaus; Nicholas C P Cross
Transcription factor mutations in myelodysplastic/myeloproliferative neoplasms.

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2011: Thomas Ernst; Joannah Score; Michael Deininger; Claire Hidalgo-Curtis; Peter Lackie; William B Ershler; John M Goldman; Nicholas C P Cross; Francis H Grand
Identification of FOXP1 and SNX2 as novel ABL1 fusion partners in acute lymphoblastic leukaemia.
British journal of haematology 2011;153(1):43-6.
2010: Joannah Score; María J Calasanz; O Ottman; F Pane; R F Yeh; M A Sobrinho-Simões; Sebastian Kreil; D Ward; C Hidalgo-Curtis; Junia V Melo; J Wiemels; B Nadel; Nicholas C P Cross; Francis H Grand
Analysis of genomic breakpoints in p190 and p210 BCR-ABL indicate distinct mechanisms of formation.
Leukemia 2010;24(10):1742-50.
2010: Thomas Ernst; Andrew Chase; Katerina Zoi; Katherine Waghorn; Claire Hidalgo-Curtis; Joannah Score; Amy Jones; Francis H Grand; Andreas Reiter; Andreas Hochhaus; Nicholas C P Cross
Transcription factor mutations in myelodysplastic/myeloproliferative neoplasms.
Haematologica 2010;95(9):1473-80.
2010: Thomas Ernst; Andrew Chase; Joannah Score; Claire E Hidalgo-Curtis; Catherine Bryant; Amy V Jones; Katherine Waghorn; Katerina Zoi; Fiona M Ross; Andreas Reiter; Andreas Hochhaus; Hans G Drexler; Andrew Duncombe; Francisco Cervantes; David Oscier; Jacqueline Boultwood; Francis H Grand; Nicholas C P Cross
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders.
Nature genetics 2010;42(8):722-6.
2010: Claire Hidalgo-Curtis; Jane F Apperley; Allistair Stark; Anthony Stark; Michael Jeng; Jason Gotlib; Andrew Chase; Nicholas C P Cross; Francis H Grand
Fusion of PDGFRB to two distinct loci at 3p21 and a third at 12q13 in imatinib-responsive myeloproliferative neoplasms.
British journal of haematology 2010;148(2):268-73.
2010: Andrew Chase; Thomas Ernst; Andreas Fiebig; ANDREW COLLINS; Francis H Grand; Philipp Erben; Andreas Reiter; Stefan Schreiber; Nicholas C P Cross
TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals.
Haematologica 2010;95(1):20-6.
2009: Francis H Grand; Claire E Hidalgo-Curtis; Thomas Ernst; Katerina Zoi; Christine Zoi; Carolann McGuire; Sebastian Kreil; Amy Jones; Joannah Score; Georgia Metzgeroth; David Oscier; Andrew Hall; Christian Brandts; Hubert Serve; Andreas Reiter; Andrew Chase; Nicholas C P Cross
Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms.
Blood 2009;113(24):6182-92.
2009: J Score; Christoph Walz; J V Jovanovic; A V Jones; Katherine Waghorn; C Hidalgo-Curtis; F Lin; D Grimwade; Francis H Grand; Andreas Reiter; Nicholas C P Cross
Detection and molecular monitoring of FIP1L1-PDGFRA-positive disease by analysis of patient-specific genomic DNA fusion junctions.
Leukemia 2009;23(2):332-9.
2009: Andrew Chase; Beate Schultheis; Sebastian Kreil; J Baxter; C Hidalgo-Curtis; A Jones; L Zhang; Francis H Grand; Junia V Melo; Nicholas C P Cross
Imatinib sensitivity as a consequence of a CSF1R-Y571D mutation and CSF1/CSF1R signaling abnormalities in the cell line GDM1.
Leukemia 2009;23(2):358-64.
2008: Claire Hidalgo-Curtis; Andrew Chase; Milton Drachenberg; Mark W Roberts; Jerry Z Finkelstein; Sarah Mould; David Oscier; Nicholas C P Cross; Francis H Grand
The t(1;9)(p34;q34) and t(8;12)(p11;q15) fuse pre-mRNA processing proteins SFPQ (PSF) and CPSF6 to ABL and FGFR1.
Genes, chromosomes & cancer 2008;47(5):379-85.
2007: Andrew Chase; Francis H Grand; Nicholas C P Cross
Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome.
Blood 2007;110(10):3729-34.
2007: Francis H Grand; Sameena Iqbal; Lingyan Zhang; Nigel H Russell; Andrew Chase; Nicholas C P Cross
A constitutively active SPTBN1-FLT3 fusion in atypical chronic myeloid leukemia is sensitive to tyrosine kinase inhibitors and immunotherapy.
Experimental hematology 2007;35(11):1723-7.
2007: C E Curtis; Francis H Grand; Katherine Waghorn; T P Sahoo; J George; Nicholas C P Cross
A novel ETV6-PDGFRB fusion transcript missed by standard screening in a patient with an imatinib responsive chronic myeloproliferative disease.
Leukemia 2007;21(8):1839-41.
2007: Claire E Curtis; Francis H Grand; Pellegrino Musto; Andrew Clark; John Murphy; Gianni Perla; Maria Marta Minervini; Janet Stewart; Andreas Reiter; Nicholas C P Cross
Two novel imatinib-responsive PDGFRA fusion genes in chronic eosinophilic leukaemia.
British journal of haematology 2007;138(1):77-81.
2007: Victoria L Earle; Fiona Ross; Andrew Fisher; Paul Strike; Samantha Berrington; Laura Chiecchio; Elisabet Dachs Cabanas; Rebecca Washbourne; Kathryn Watts; Francis H Grand
Haemopoietic growth factors significantly improve the mitotic index and chromosome quality in cytogenetic cultures of myeloid neoplasia.
Genes, chromosomes & cancer 2007;46(7):670-4.
2007: Marianna David; Nicholas C P Cross; Sonja Burgstaller; Andrew Chase; Claire Curtis; Raymond Dang; Martine Gardembas; John M Goldman; Francis H Grand; George Hughes; Francoise Huguet; Louise Lavender; Grant A McArthur; François-Xavier Mahon; Giorgio Massimini; Junia Melo; Philippe Rousselot; Robin J Russell-Jones; John F Seymour; Graeme Smith; Alastair Stark; Katherine Waghorn; Zariana Nikolova; Jane F Apperley
Durable responses to imatinib in patients with PDGFRB fusion gene-positive and BCR-ABL-negative chronic myeloproliferative disorders.
Blood 2007;109(1):61-4.
2006: Joannah Score; Claire Curtis; Katherine Waghorn; M Stalder; M Jotterand; Francis H Grand; Nicholas C P Cross
Identification of a novel imatinib responsive KIF5B-PDGFRA fusion gene following screening for PDGFRA overexpression in patients with hypereosinophilia.
Leukemia 2006;20(5):827-32.
2005: Francis H Grand; Prasad R K Koduru; Nicholas C P Cross; Steven Allen
NUP98-LEDGF fusion and t(9;11) in transformed chronic myeloid leukemia.
Leukemia research 2005;29(12):1469-72.
2005: Amy V Jones; Sebastian Kreil; Katerina Zoi; Katherine Waghorn; Claire Curtis; Lingyan Zhang; Joannah Score; Rachel Seear; Andrew Chase; Francis H Grand; Helen White; Christine Zoi; Dimitris Loukopoulos; Evangelos Terpos; Elisavet-Christine Vervessou; Beate Schultheis; Michael Emig; Thomas Ernst; Eva Lengfelder; Rüdiger Hehlmann; Andreas Hochhaus; David Oscier; Richard T Silver; Andreas Reiter; Nicholas C P Cross
Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders.
Blood 2005;106(6):2162-8.
2005: David Dingli; Francis H Grand; Victor Mahaffey; Jack L Spurbeck; Fiona M Ross; Ann Watmore; John T Reilly; Nicholas C P Cross; Gordon W Dewald; Ayalew Tefferi
Der(6)t(1;6)(q21-23;p21.3): a specific cytogenetic abnormality in myelofibrosis with myeloid metaplasia.
British journal of haematology 2005;130(2):229-32.
2005: María D Odero; Francis H Grand; S Iqbal; F Ross; J P Roman; José L Vizmanos; Joris Andrieux; Jean-Luc Laï; María J Calasanz; Nicholas C P Cross
Disruption and aberrant expression of HMGA2 as a consequence of diverse chromosomal translocations in myeloid malignancies.
Leukemia 2005;19(2):245-52.
2004: Francis H Grand; Sonja Burgstaller; Thomas Kühr; E Joanna Baxter; Gerald Webersinke; Josef Thaler; Andrew Chase; Nicholas C P Cross
p53-Binding protein 1 is fused to the platelet-derived growth factor receptor beta in a patient with a t(5;15)(q33;q22) and an imatinib-responsive eosinophilic myeloproliferative disorder.
Cancer research 2004;64(20):7216-9.
2004: Effie K Grand; Francis H Grand; Andrew Chase; Fiona M Ross; Martin M Corcoran; David Oscier; Nicholas C P Cross
Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome.
Genes, chromosomes & cancer 2004;40(1):78-83.
2000: Myrtle Y Gordon; Stephen B Marley; R John Davidson; Francis H Grand; John L Lewis; DX Nguyen; S Lloyd; John M Goldman
Contact-mediated inhibition of human haematopoietic progenitor cell proliferation may be conferred by stem cell antigen, CD34.
The hematology journal : the official journal of the European Haematology Association / EHA 2000;1(2):77-86.
1999: Francis H Grand; Shashikant Kulkarni; Andrew Chase; John M Goldman; M Gordon; Nicholas C P Cross
Frequent deletion of hSNF5/INI1, a component of the SWI/SNF complex, in chronic myeloid leukemia.
Cancer research 1999;59(16):3870-4.
1999: Myrtle Y Gordon; Francesco Dazzi; Stephen B Marley; John L Lewis; D Nguyen; Francis H Grand; R John Davidson; John M Goldman
Cell biology of CML cells.
Leukemia 1999;13 Suppl 1():S65-71.
1999: A Spencer; Richard Szydlo; Francis H Grand; John M Goldman; J V Melo
Abnormal patterns of immunoglobulin heavy chain gene DNA fingerprinting during chronic phase chronic myeloid leukemia.
Leukemia & lymphoma 1999;32(3-4):299-307.
1998: Francis H Grand; Andrew Chase; S Iqbal; DX Nguyen; John L Lewis; Stephen B Marley; R John Davidson; John M Goldman; Myrtle Y Gordon
A two-color BCR-ABL probe that greatly reduces the false positive and false negative rates for fluorescence in situ hybridization in chronic myeloid leukemia.
Genes, chromosomes & cancer 1998;23(2):109-15.
1998: Myrtle Y Gordon; Stephen B Marley; John L Lewis; R John Davidson; DX Nguyen; Francis H Grand; T A Amos; John M Goldman
Treatment with interferon-alpha preferentially reduces the capacity for amplification of granulocyte-macrophage progenitors (CFU-GM) from patients with chronic myeloid leukemia but spares normal CFU-GM.
The Journal of clinical investigation 1998;102(4):710-5.
1997: Francis H Grand; Stephen B Marley; Andrew Chase; I Titley; L Healy; A Spencer; A Reiter; J M Goldman; Myrtle Y Gordon
BCR/ABL-negative progenitors are enriched in the adherent fraction of CD34+ cells circulating in the blood of chronic phase chronic myeloid leukemia patients.
Leukemia 1997;11(9):1486-92.
1997: Andrew Chase; Francis H Grand; J G Zhang; N Blackett; J Goldman; M Gordon
Factors influencing the false positive and negative rates of BCR-ABL fluorescence in situ hybridization.
Genes, chromosomes & cancer 1997;18(4):246-53.
1997: Myrtle Y Gordon; John L Lewis; Stephen B Marley; Francis H Grand; John M Goldman
Stromal cells negatively regulate primitive haemopoietic progenitor cell activation via a phosphatidylinositol-anchored cell adhesion/signalling mechanism.
British journal of haematology 1997;96(3):647-53.
1996: Myrtle Y Gordon; John L Lewis; Francis H Grand; Stephen B Marley; John M Goldman
Phenotype and progeny of primitive adherent human hematopoietic progenitors.
Leukemia 1996;10(8):1347-53.
1995: T A Amos; John L Lewis; Francis H Grand; R P Gooding; John M Goldman; Myrtle Y Gordon
Apoptosis in chronic myeloid leukaemia: normal responses by progenitor cells to growth factor deprivation, X-irradiation and glucocorticoids.
British journal of haematology 1995;91(2):387-93.