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Jane Grande-Allen

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Narin Osman; Silvana Marasco; Kevin D O'Brien; Mandy L Ballinger; Robel Getachew; K Jane Grande-Allen; Peter J Little
Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans.
Hubert Tseng; Jennifer L West; Chris J Lin; Maude L Cuchiara; Michael P Cuchiara; Christopher A Durst; K Jane Grande-Allen
Fabrication and mechanical evaluation of anatomically-inspired quasilaminate hydrogel structures with layer-specific formulations.
Elizabeth H Stephens; Paul H Weigel; Kristin M Anderson; L Scott Baggett; Liezl R Balaoing; Alan R Davis; Joel D Morrisett; Indrajit Nandi; Alan Davis; Michael J Reardon; Jerome G Saltarrelli; Melanie A Simpson; K Jane Grande-Allen
Hyaluronan turnover and hypoxic brown adipocytic differentiation are co-localized with ossification in calcified human aortic valves.

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All Publications

2013: Narin Osman; Silvana Marasco; Kevin D O'Brien; Mandy L Ballinger; Robel Getachew; K Jane Grande-Allen; Peter J Little
Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2013;22(2):146-55.
2013: Hubert Tseng; Jennifer L West; Chris J Lin; Maude L Cuchiara; Michael P Cuchiara; Christopher A Durst; K Jane Grande-Allen
Fabrication and mechanical evaluation of anatomically-inspired quasilaminate hydrogel structures with layer-specific formulations.
Annals of biomedical engineering 2013;41(2):398-407.
2012: Elizabeth H Stephens; Paul H Weigel; Kristin M Anderson; L Scott Baggett; Liezl R Balaoing; Alan R Davis; Joel D Morrisett; Indrajit Nandi; Alan Davis; Michael J Reardon; Jerome G Saltarrelli; Melanie A Simpson; K Jane Grande-Allen
Hyaluronan turnover and hypoxic brown adipocytic differentiation are co-localized with ossification in calcified human aortic valves.
Pathology, research and practice 2012;208(11):642-50.
2012: Patrick S Connell; Richard I Han; K Jane Grande-Allen
Differentiating the aging of the mitral valve from human and canine myxomatous degeneration.
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology 2012;14(1):31-45.
2011: Elizabeth H Stephens; L Scott Baggett; Alan R Davis; Joyce J Kuo; Joel D Morrisett; Indrajit Nandi; Elizabeth A Olmsted-Davis; Michael J Reardon; Jerome G Saltarrelli; K Jane Grande-Allen
Differential proteoglycan and hyaluronan distribution in calcified aortic valves.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2011;20(6):334-42.
2011: Nalini M Rajamannan; Frederick J Schoen; Craig A Simmons; Dwight A Towler; Ajit P Yoganathan; Elena Aikawa; Linda L Demer; Frank J Evans; K Jane Grande-Allen; Donald D Heistad; Kristyn S Masters; Patrick Mathieu; Kevin D O'Brien; Catherine M Otto
Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update.
Circulation 2011;124(16):1783-91.
2011: Elizabeth H Stephens; Debra L Kearney; Joyce J Kuo; Jennifer Shangkuan; Kathleen E Carberry; Joshua L Carroll; Charles D Fraser; K Jane Grande-Allen
Extracellular matrix remodeling and cell phenotypic changes in dysplastic and hemodynamically altered semilunar human cardiac valves.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2011;20(5):e157-67.
2011: Christopher A Durst; Michael P Cuchiara; Elizabeth G Mansfield; Jennifer L West; K Jane Grande-Allen
Flexural characterization of cell encapsulated PEGDA hydrogels with applications for tissue engineered heart valves.
Acta biomaterialia 2011;7(6):2467-76.
2011: H Tseng; K Jane Grande-Allen
Elastic fibers in the aortic valve spongiosa: a fresh perspective on its structure and role in overall tissue function.
Acta biomaterialia 2011;7(5):2101-8.
2011: K Jane Grande-Allen; Jun Liao
The heterogeneous biomechanics and mechanobiology of the mitral valve: implications for tissue engineering.
Current cardiology reports 2011;13(2):113-20.
2011: Xin Qu; Andrea Carolina Jimenez-Vergara; Dany J Munoz-Pinto; Diana Ortiz; Rebecca E McMahon; Deissy Cristancho; Silvia Becerra-Bayona; Viviana Guiza-Arguello; K Jane Grande-Allen; Mariah S Hahn
Regulation of smooth muscle cell phenotype by glycosaminoglycan identity.
Acta biomaterialia 2011;7(3):1031-9.
2011: Elizabeth H Stephens; Christopher A Durst; Jennifer L West; K Jane Grande-Allen
Mitral valvular interstitial cell responses to substrate stiffness depend on age and anatomic region.
Acta biomaterialia 2011;7(1):75-82.
2010: Jiehong Liao; Xuan Guo; K Jane Grande-Allen; F Kurtis Kasper; Antonios G Mikos
Bioactive polymer/extracellular matrix scaffolds fabricated with a flow perfusion bioreactor for cartilage tissue engineering.
Biomaterials 2010;31(34):8911-20.
2010: Elizabeth H Stephens; Joshua L Carroll; Allison D Post; Joyce J Kuo; K Jane Grande-Allen
Functional characterization of fibronectin-separated valve interstitial cell subpopulations in three-dimensional culture.
The Journal of heart valve disease 2010;19(6):759-65.
2010: Janet E Barzilla; Anna S McKenney; Ashley E Cowan; Christopher A Durst; K Jane Grande-Allen
Design and validation of a novel splashing bioreactor system for use in mitral valve organ culture.
Annals of biomedical engineering 2010;38(11):3280-94.
2010: Elizabeth H Stephens; Allison D Post; Daniel R Laucirica; K Jane Grande-Allen
Perinatal changes in mitral and aortic valve structure and composition.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 2010;13(6):447-58.
2010: Janet E Barzilla; Frances E Acevedo; K Jane Grande-Allen
Organ culture as a tool to identify early mechanisms of serotonergic valve disease.
The Journal of heart valve disease 2010;19(5):626-35.
2010: Z Ferdous; S B Peterson; H Tseng; D K Anderson; R V Iozzo; K Jane Grande-Allen
A role for decorin in controlling proliferation, adhesion, and migration of murine embryonic fibroblasts.
Journal of biomedical materials research. Part A 2010;93(2):419-28.
2010: Elizabeth H Stephens; Nicky de Jonge; Meaghan P McNeill; Christopher A Durst; K Jane Grande-Allen
Age-related changes in material behavior of porcine mitral and aortic valves and correlation to matrix composition.
Tissue engineering. Part A 2010;16(3):867-78.
2010: Shuai Xu; K Jane Grande-Allen
The role of cell biology and leaflet remodeling in the progression of heart valve disease.
Methodist DeBakey cardiovascular journal 2010;6(1):2-7.
2010: Elizabeth H Stephens; Thanh N Huynh; Jennifer D Cieluch; K Jane Grande-Allen
Fibronectin-based isolation of valve interstitial cell subpopulations: relevance to valve disease.
Journal of biomedical materials research. Part A 2010;92(1):340-9.
2009: Elizabeth H Stephens; Tomasz A Timek; George T Daughters; Joyce J Kuo; Aaron M Patton; L Scott Baggett; Neil B Ingels; D Craig Miller; K Jane Grande-Allen
Significant changes in mitral valve leaflet matrix composition and turnover with tachycardia-induced cardiomyopathy.
Circulation 2009;120(11 Suppl):S112-9.
2009: Vishal Gupta; Janet E Barzilla; Joe S Mendez; Elizabeth H Stephens; Elaine L Lee; Charles Collard; Rodolfo Laucirica; Paul H Weigel; K Jane Grande-Allen
Abundance and location of proteoglycans and hyaluronan within normal and myxomatous mitral valves.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2009;18(4):191-7.
2009: David D Allison; Kathleen R Braun; Thomas N Wight; K Jane Grande-Allen
Differential effects of exogenous and endogenous hyaluronan on contraction and strength of collagen gels.
Acta biomaterialia 2009;5(4):1019-26.
2008: Elizabeth H Stephens; Tom C Nguyen; Akinobu Itoh; Neil B Ingels; D Craig Miller; K Jane Grande-Allen
The effects of mitral regurgitation alone are sufficient for leaflet remodeling.
Circulation 2008;118(14 Suppl):S243-9.
2008: Elizabeth H Stephens; Chia-Kai Chu; K Jane Grande-Allen
Valve proteoglycan content and glycosaminoglycan fine structure are unique to microstructure, mechanical load and age: Relevance to an age-specific tissue-engineered heart valve.
Acta biomaterialia 2008;4(5):1148-60.
2008: David D Allison; Thomas N Wight; Nicolas J Ripp; Kathleen R Braun; K Jane Grande-Allen
Endogenous overexpression of hyaluronan synthases within dynamically cultured collagen gels: Implications for vascular and valvular disease.
Biomaterials 2008;29(20):2969-76.
2008: Vishal Gupta; Jennifer A Werdenberg; Brian D Lawrence; Joe S Mendez; Elizabeth H Stephens; K Jane Grande-Allen
Reversible secretion of glycosaminoglycans and proteoglycans by cyclically stretched valvular cells in 3D culture.
Annals of biomedical engineering 2008;36(7):1092-103.
2008: Zannatul Ferdous; Luis D Lazaro; Renato V Iozzo; Magnus Höök; K Jane Grande-Allen
Influence of cyclic strain and decorin deficiency on 3D cellularized collagen matrices.
Biomaterials 2008;29(18):2740-8.
2008: Mariah S Hahn; Cindy Y Jao; William Faquin; K Jane Grande-Allen
Glycosaminoglycan composition of the vocal fold lamina propria in relation to function.
The Annals of otology, rhinology, and laryngology 2008;117(5):371-81.
2008: Anita Saraf; Michael C Hacker; Balaji Sitharaman; K Jane Grande-Allen; Michael A Barry; Antonios G Mikos
Synthesis and conformational evaluation of a novel gene delivery vector for human mesenchymal stem cells.
Biomacromolecules 2008;9(3):818-27.
2008: Gidon Ofek; Christopher M Revell; Jerry C Hu; David D Allison; K Jane Grande-Allen; Kyriacos A Athanasiou
Matrix development in self-assembly of articular cartilage.
PloS one 2008;3(7):e2795.
2008: Tracy L Blevins; Sherket B Peterson; Elaine L Lee; Annie M Bailey; Jonathan D Frederick; Thanh N Huynh; Vishal Gupta; K Jane Grande-Allen
Mitral valvular interstitial cells demonstrate regional, adhesional, and synthetic heterogeneity.
Cells, tissues, organs 2008;187(2):113-22.
2007: Zannatul Ferdous; Victoria Mariko Wei; Renato Iozzo; Magnus Höök; K Jane Grande-Allen
Decorin-transforming growth factor- interaction regulates matrix organization and mechanical characteristics of three-dimensional collagen matrices.
The Journal of biological chemistry 2007;282(49):35887-98.
2007: David D Allison; Natalia Vasco; Kathleen R Braun; Thomas N Wight; K Jane Grande-Allen
The effect of endogenous overexpression of hyaluronan synthases on material, morphological, and biochemical properties of uncrosslinked collagen biomaterials.
Biomaterials 2007;28(36):5509-17.
2007: Elizabeth H Stephens; K Jane Grande-Allen
Age-related changes in collagen synthesis and turnover in porcine heart valves.
The Journal of heart valve disease 2007;16(6):672-82.
2007: K Jane Grande-Allen; Narin Osman; Mandy L Ballinger; H Dadlani; S Marasco; Peter Little
Glycosaminoglycan synthesis and structure as targets for the prevention of calcific aortic valve disease.
Cardiovascular research 2007;76(1):19-28.
2007: Zannatul Ferdous; K Jane Grande-Allen
Utility and control of proteoglycans in tissue engineering.
Tissue engineering 2007;13(8):1893-904.
2007: Elizabeth H Stephens; Joshua L Carroll; K Jane Grande-Allen
The use of collagenase III for the isolation of porcine aortic valvular interstitial cells: rationale and optimization.
The Journal of heart valve disease 2007;16(2):175-83.
2007: Vishal Gupta; Jennifer A Werdenberg; Tracy L Blevins; K Jane Grande-Allen
Synthesis of glycosaminoglycans in differently loaded regions of collagen gels seeded with valvular interstitial cells.
Tissue engineering 2007;13(1):41-9.
2006: Vishal Gupta; K Jane Grande-Allen
Effects of static and cyclic loading in regulating extracellular matrix synthesis by cardiovascular cells.
Cardiovascular research 2006;72(3):375-83.
2006: Tracy L Blevins; Joshua L Carroll; Alina M Raza; K Jane Grande-Allen
Phenotypic characterization of isolated valvular interstitial cell subpopulations.
The Journal of heart valve disease 2006;15(6):815-22.
2006: Janet E Barzilla; Tracy L Blevins; K Jane Grande-Allen
Age-related structural changes in cardiac valves: implications for tissue-engineered repairs.
The American journal of geriatric cardiology 2006;15(5):311-5.
2006: David D Allison; K Jane Grande-Allen
Review. Hyaluronan: a powerful tissue engineering tool.
Tissue engineering 2006;12(8):2131-40.
2005: K Jane Grande-Allen; J Edward Barber; Katrina M Klatka; Penny L Houghtaling; Ivan Vesely; Christine S Moravec; Patrick M McCarthy
Mitral valve stiffening in end-stage heart failure: evidence of an organic contribution to functional mitral regurgitation.
The Journal of thoracic and cardiovascular surgery 2005;130(3):783-90.
2005: K Jane Grande-Allen; Allen Borowski; Richard W Troughton; Penny L Houghtaling; Nicholas R DiPaola; Christine S Moravec; Ivan Vesely; Brian P Griffin
Apparently normal mitral valves in patients with heart failure demonstrate biochemical and structural derangements: an extracellular matrix and echocardiographic study.
Journal of the American College of Cardiology 2005;45(1):54-61.
2004: K Jane Grande-Allen; Anthony Calabro; Vishal Gupta; Thomas N Wight; Vincent C Hascall; Ivan Vesely
Glycosaminoglycans and proteoglycans in normal mitral valve leaflets and chordae: association with regions of tensile and compressive loading.
Glycobiology 2004;14(7):621-33.
2004: David D Allison; Judith A Drazba; Ivan Vesely; Khalid N Kader; K Jane Grande-Allen
Cell viability mapping within long-term heart valve organ cultures.
The Journal of heart valve disease 2004;13(2):290-6.
2004: K Jane Grande-Allen
Fibrotic vs. myxomatous remodeling of mitral valves.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2004;5():3737-40.
2003: K Jane Grande-Allen; Brian P Griffin; Norman B Ratliff; Delos M Cosgrove; Ivan Vesely
Glycosaminoglycan profiles of myxomatous mitral leaflets and chordae parallel the severity of mechanical alterations.
Journal of the American College of Cardiology 2003;42(2):271-7.
2003: Vincent Setola; Sandra J Hufeisen; K Jane Grande-Allen; Ivan Vesely; Richard A Glennon; Bruce Blough; Richard B Rothman; Bryan L Roth
3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.
Molecular pharmacology 2003;63(6):1223-9.
2003: K Jane Grande-Allen; W John Mako; Anthony Calabro; Yaling Shi; Norman B Ratliff; Ivan Vesely
Loss of chondroitin 6-sulfate and hyaluronan from failed porcine bioprosthetic valves.
Journal of biomedical materials research. Part A 2003;65(2):251-9.
2002: Daniela G Seidler; Egon Breuer; K Jane Grande-Allen; Vincent C Hascall; Hans Kresse
Core protein dependence of epimerization of glucuronosyl residues in galactosaminoglycans.
The Journal of biological chemistry 2002;277(44):42409-16.
2002: Kyra L Sedransk; K Jane Grande-Allen; Ivan Vesely
Failure mechanics of mitral valve chordae tendineae.
The Journal of heart valve disease 2002;11(5):644-50.
2001: K Jane Grande-Allen; Richard P Cochran; Per G Reinhall; Karyn S Kunzelman
Mechanisms of aortic valve incompetence: finite-element modeling of Marfan syndrome.
The Journal of thoracic and cardiovascular surgery 2001;122(5):946-54.
2001: K Jane Grande-Allen; Richard P Cochran; Per G Reinhall; Karyn S Kunzelman
Finite-element analysis of aortic valve-sparing: influence of graft shape and stiffness.
IEEE transactions on bio-medical engineering 2001;48(6):647-59.
2001: K Jane Grande-Allen; Brian P Griffin; Anthony Calabro; Norman B Ratliff; Delos M Cosgrove; Ivan Vesely
Myxomatous mitral valve chordae. II: Selective elevation of glycosaminoglycan content.
The Journal of heart valve disease 2001;10(3):325-32; discussion 332-3.
2001: K Jane Grande-Allen; Norman B Ratliff; Brian P Griffin; Delos M Cosgrove; Ivan Vesely
Case report: outer sheath rupture may precede complete chordal rupture in fibrotic mitral valve disease.
The Journal of heart valve disease 2001;10(1):90-3.
2000: K Jane Grande-Allen; Richard P Cochran; Per G Reinhall; Karyn S Kunzelman
Re-creation of sinuses is important for sparing the aortic valve: a finite element study.
The Journal of thoracic and cardiovascular surgery 2000;119(4 Pt 1):753-63.