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Per-Olof Grände

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Living Beings

Cats

Physiology

Anatomy

Chemicals & Drugs

Disorders

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Hydrostatic Pressure

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Co-Publications
Name
14
Nordström, Carl-Henrik
13
Bentzer, Peter
12
Asgeirsson, B
7
Holbeck, Staffan
7
Kongstad, L
5
Borgström, Per
4
Lundblad, Cornelia
4
Naredi, Silvana
4
Persson, Johan
4
Romner, Bertil
3
Reinstrup, Peter
3
Koskinen, L-O
2
Eker, C
2
Lindberg, Lars
2
Möller, AD

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Publications

TOP 3
Grände P-O; Reinstrup P; Romner B
Active cooling in traumatic brain-injured patients: a questionable therapy?
Grände Per-Olof; Reinstrup Peter
Do conventional treatments of severe traumatic head injury worsen outcome?
Mårtensson Ulrika E A; Salehi S Albert; Windahl Sara; Gomez Maria F; Swärd Karl; Daszkiewicz-Nilsson Joanna; Wendt Anna; Andersson Niklas; Hellstrand Per; Grände Per-Olof; Owman Christer; Rosen Clifford J; Adamo Martin L; Lundquist Ingmar; Rorsman Patrik; Nilsson Bengt-Olof; Ohlsson Claes; Olde Björn; Leeb-Lundberg L M Fredrik
Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice.

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All Publications

2009: Grände P-O; Reinstrup P; Romner B
Active cooling in traumatic brain-injured patients: a questionable therapy?
Acta anaesthesiologica Scandinavica 2009;53(10):1233-8.
2009: Grände Per-Olof; Reinstrup Peter
Do conventional treatments of severe traumatic head injury worsen outcome?
The Journal of trauma 2009;67(2):415-6.
2009: Mårtensson Ulrika E A; Salehi S Albert; Windahl Sara; Gomez Maria F; Swärd Karl; Daszkiewicz-Nilsson Joanna; Wendt Anna; Andersson Niklas; Hellstrand Per; Grände Per-Olof; Owman Christer; Rosen Clifford J; Adamo Martin L; Lundquist Ingmar; Rorsman Patrik; Nilsson Bengt-Olof; Ohlsson Claes; Olde Björn; Leeb-Lundberg L M Fredrik
Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice.
Endocrinology 2009;150(2):687-98.
2008: Romner Bertil; Grände Per-Olof
[No scientific support for hypothermia therapy in severe craniocerebral injury. The treatment can even be dangerous]
Läkartidningen 2008;105(47):3406-7.
2008: Grände Per-Olof; Romner Bertil
[LP in a patient with bacterial meningitis and reduced consciousness--benefits do not outweigh the risks]
Läkartidningen 2008;105(45):3216.
2008: Dubniks Maris; Grände Per-Olof
Change in plasma volume from a state of hyper-, normo- or hypovolemia with or without noradrenalin infusion in the rat.
Microvascular research 2008;76(2):75-9.
2008: Grände Per-Olof
Time out for albumin or a valuable therapeutic component in severe head injury?
Acta anaesthesiologica Scandinavica 2008;52(6):738-41.
2008: Dubniks M; Grände P-O
The effects of activated protein C and prostacyclin on arterial oxygenation and protein leakage in the lung and the gut under endotoxaemia in the rat.
Acta anaesthesiologica Scandinavica 2008;52(3):381-7.
2008: Lundblad Cornelia; Grände Per-Olof; Bentzer Peter
Increased cortical cell loss and prolonged hemodynamic depression after traumatic brain injury in mice lacking the IP receptor for prostacyclin.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(2):367-76.
2007: Dubniks Maris; Persson Johan; Grände Per-Olof
Effect of blood pressure on plasma volume loss in the rat under increased permeability.
Intensive care medicine 2007;33(12):2192-8.
2007: Grände P-O; Koskinen L-O; Naredi S; Reinstrup P; Romner B
Conventional treatments for severe head injury: are they effective, ineffective, or even harmful?
Acta anaesthesiologica Scandinavica 2007;51(10):1294-6.
2007: Dubniks Maris; Persson Johan; Grände Per-Olof
Plasma volume expansion of 5% albumin, 4% gelatin, 6% HES 130/0.4, and normal saline under increased microvascular permeability in the rat.
Intensive care medicine 2007;33(2):293-9.
2006: Grände Per-Olof; Bentzer Peter
Hypertonic saline: a marker for discrimination between a disrupted and intact blood-brain barrier?
Critical care medicine 2006;34(12):3057-8.
2006: Grände Per-Olof
The "Lund Concept" for the treatment of severe head trauma--physiological principles and clinical application.
Intensive care medicine 2006;32(10):1475-84.
2006: Persson Johan; Grände Per-Olof
Plasma volume expansion and transcapillary fluid exchange in skeletal muscle of albumin, dextran, gelatin, hydroxyethyl starch, and saline after trauma in the cat.
Critical care medicine 2006;34(9):2456-62.
2005: Grände P-O
Mechanisms behind postspinal headache and brain stem compression following lumbar dural puncture--a physiological approach.
Acta anaesthesiologica Scandinavica 2005;49(5):619-26.
2005: Kongstad L; Grände P-O
Effects on intracranial pressure of dural puncture in supine and head-elevated positions. A study on the cat.
Acta anaesthesiologica Scandinavica 2005;49(5):614-8.
2005: Persson Johan; Grände Per-Olof
Volume expansion of albumin, gelatin, hydroxyethyl starch, saline and erythrocytes after haemorrhage in the rat.
Intensive care medicine 2005;31(2):296-301.
2004: Lundblad Cornelia; Bentzer Peter; Grände P O
The permeability-reducing effects of prostacyclin and inhibition of Rho kinase do not counteract endotoxin-induced increase in permeability in cat skeletal muscle.
Microvascular research 2004;68(3):286-94.
2004: Lundblad C; Grände P O; Bentzer P
A mouse model for evaluation of capillary perfusion, microvascular permeability, cortical blood flow, and cortical edema in the traumatized brain.
Journal of neurotrauma 2004;21(6):741-53.
2004: Persson Johan; Morsing Peter; Grände Per-Olof
Vasopeptidase inhibition with omapatrilat increases fluid and protein microvascular permeability in cat skeletal muscle.
Journal of hypertension 2004;22(3):637-44.
2004: Bentzer Peter; Grände P O
Low-dose prostacyclin restores an increased protein permeability after trauma in cat skeletal muscle.
The Journal of trauma 2004;56(2):385-92.
2003: Persson Johan; Ekelund Ulf; Grände Per Olof
Endogenous nitric oxide reduces microvascular permeability and tissue oedema during exercise in cat skeletal muscle.
Journal of vascular research 2003;40(6):538-46.
2003: Naredi Silvana; Koskinen Lars-Ove; Grände P-O; Nordström Carl-Henrik; Nellgård Bengt; Rydenhag Bertil; Vegfors Magnus
Treatment of traumatic head injury--U.S./European guidelines or the Lund concept.
Critical care medicine 2003;31(11):2713-4.
2003: Lundblad C; Bentzer P; Grände P O
Inhibition of Rho kinase decreases hydraulic and protein microvascular permeability in cat skeletal muscle.
Microvascular research 2003;66(2):126-33.
2003: Bentzer Peter; Venturoli Daniele; Carlsson Ola; Grände P-O
Low-dose prostacyclin improves cortical perfusion following experimental brain injury in the rat.
Journal of neurotrauma 2003;20(5):447-61.
2003: Persson Johan; Ekelund Ulf; Grände Per-Olof
Nitric oxide and prostacyclin play a role in the regulation of microvascular protein and hydraulic permeability in cat skeletal muscle.
Microcirculation (New York, N.Y. : 1994) 2003;10(2):233-43.
2003: Holbeck Staffan; Grände Per-Olof
Endotoxin increases both protein and fluid microvascular permeability in cat skeletal muscle.
Critical care medicine 2003;31(2):560-5.
2002: Holbeck Staffan; Grände Per-Olof
Hypovolemia is a main factor behind disturbed perfusion and metabolism in the intestine during endotoxemia in cat.
Shock (Augusta, Ga.) 2002;18(4):367-73.
2002: Grände P-O; Asgeirsson B; Nordström C-H
Volume-targeted therapy of increased intracranial pressure: the Lund concept unifies surgical and non-surgical treatments.
Acta anaesthesiologica Scandinavica 2002;46(8):929-41.
2002: Grände Per-Olof; Naredi Silvana
Clinical studies in severe traumatic brain injury: a controversial issue.
Intensive care medicine 2002;28(5):529-31.
2002: Grände P-O; Myhre E B; Nordström C-H; Schliamser S
Treatment of intracranial hypertension and aspects on lumbar dural puncture in severe bacterial meningitis.
Acta anaesthesiologica Scandinavica 2002;46(3):264-70.
2002: Holbeck Staffan; Bentzer Peter; Grände Per-Olof
Effects of hypertonic saline, mannitol, and urea with regard to absorption and rebound filtration in cat skeletal muscle.
Critical care medicine 2002;30(1):212-7.
2002: Bentzer Peter; Holbeck Staffan; Grände Per-Olof
Endothelin-1 reduces microvascular fluid permeability through secondary release of prostacyclin in cat Skeletal muscle.
Microvascular research 2002;63(1):50-60.
2001: Kongstad L; Grände P O
Arterial hypertension increases intracranial pressure in cat after opening of the blood-brain barrier.
The Journal of trauma 2001;51(3):490-6.
2001: Bentzer P; Kongstad L; Grände P O
Capillary filtration coefficient is independent of number of perfused capillaries in cat skeletal muscle.
American journal of physiology. Heart and circulatory physiology 2001;280(6):H2697-706.
2001: Naredi S; Olivecrona M; Lindgren C; Ostlund A L; Grände P O; Koskinen L O
An outcome study of severe traumatic head injury using the "Lund therapy" with low-dose prostacyclin.
Acta anaesthesiologica Scandinavica 2001;45(4):402-6.
2001: Möller A D; Grände P O
Beneficial effects of low-dose prostacyclin on cat intestinal perfusion during endotoxemia as evaluated with microdialysis and oxygen transport variables.
Critical care medicine 2001;29(2):351-8.
2001: Holbeck S; Bentzer P; Wikstrand C; Grände P O
Dextran, gelatin, and hydroxyethyl starch do not affect permeability for albumin in cat skeletal muscle.
Critical care medicine 2001;29(1):123-8.
2000: Grände P O
Pathophysiology of brain insult. Therapeutic implications with the Lund Concept.
Schweizerische medizinische Wochenschrift 2000;130(42):1538-43.
2000: Eker C; Schalén W; Asgeirsson B; Grände P O; Ranstam J; Nordström C H
Reduced mortality after severe head injury will increase the demands for rehabilitation services.
Brain injury : [BI] 2000;14(7):605-19.
2000: Bentzer P; Davidsson H; Grände P O
Microdialysis-based long-term measurements of energy-related metabolites in the rat brain following a fluid percussion trauma.
Journal of neurotrauma 2000;17(5):441-7.
2000: Holbeck S; Grände P O
Effects on capillary fluid permeability and fluid exchange of albumin, dextran, gelatin, and hydroxyethyl starch in cat skeletal muscle.
Critical care medicine 2000;28(4):1089-95.
1999: Bentzer P; Holbeck S; Grände P O
Prostacyclin reduces microvascular fluid conductivity in cat skeletal muscle through opening of ATP-dependent potassium channels.
Journal of vascular research 1999;36(6):516-23.
1999: Möller A D; Grände P O
Role of prostacyclin and nitric oxide in regulation of basal microvascular hydraulic permeability in cat skeletal muscle.
Journal of vascular research 1999;36(3):245-52.
1999: Kongstad L; Grände P O
The role of arterial and venous pressure for volume regulation of an organ enclosed in a rigid compartment with application to the injured brain.
Acta anaesthesiologica Scandinavica 1999;43(5):501-8.
1999: Kongstad L; Möller A D; Grände P O
Reflection coefficient for albumin and capillary fluid permeability in cat calf muscle after traumatic injury.
Acta physiologica Scandinavica 1999;165(4):369-77.
1999: Kongstad L; Grände P O
Local vascular response during organ elevation. A model for cerebral effects of upright position and dural puncture.
Acta anaesthesiologica Scandinavica 1999;43(4):438-46.
1999: Möller A D; Grände P O
Low-dose prostacyclin is superior to terbutaline and aminophylline in reducing capillary permeability in cat skeletal muscle in vivo.
Critical care medicine 1999;27(1):130-6.
1998: Eker C; Asgeirsson B; Grände P O; Schalén W; Nordström C H
Improved outcome after severe head injury with a new therapy based on principles for brain volume regulation and preserved microcirculation.
Critical care medicine 1998;26(11):1881-6.
1998: Kongstad L; Grände P O
The capillary filtration coefficient for evaluation of capillary fluid permeability in cat calf muscles.
Acta physiologica Scandinavica 1998;164(2):201-11.
1997: Möller A D; Grände P O
Low-dose prostacyclin has potent capillary permeability-reducing effect in cat skeletal muscle in vivo.
The American journal of physiology 1997;273(1 Pt 2):H200-7.
1997: Grände P O; Asgeirsson B; Nordström C H
Physiologic principles for volume regulation of a tissue enclosed in a rigid shell with application to the injured brain.
The Journal of trauma 1997;42(5 Suppl):S23-31.
1997: Jahr J; Grände P O
Peripheral circulatory effects of pump perfusion on cat skeletal muscle with and without prostacyclin.
Acta physiologica Scandinavica 1997;159(2):93-100.
1997: Grände P O; Asgeirsson B; Nordström C
Aspects on the cerebral perfusion pressure during therapy of a traumatic head injury.
Acta anaesthesiologica Scandinavica. Supplementum 1997;110():36-40.
1996: Jahr J; Grände P O
Prostacyclin counteracts the increase in capillary permeability induced by tumour necrosis factor-alpha.
Intensive care medicine 1996;22(12):1453-60.
1996: Grände P O; Nordström C H
Dihydroergotamine in the treatment of head injury--risk of gangrene and renal failure.
Acta anaesthesiologica Scandinavica 1996;40(10):1255-7.
1996: Jahr J; Grände P O
In vivo effects of tumor necrosis factor-alpha on capillary permeability and vascular tone in a skeletal muscle.
Acta anaesthesiologica Scandinavica 1996;40(2):256-61.
1996: Asgeirsson B; Grände P O
Local vascular responses to elevation of an organ above the heart.
Acta physiologica Scandinavica 1996;156(1):9-18.
1995: Asgeirsson B; Grände P O; Nordström C H; Messeter K; Sjöholm H
Cerebral haemodynamic effects of dihydroergotamine in patients with severe traumatic brain lesions.
Acta anaesthesiologica Scandinavica 1995;39(7):922-30.
1995: Nilsson F; Messeter K; Grände P O; Rosén I; Ryding E; Nordström C H
Effects of dihydroergotamine on cerebral circulation during experimental intracranial hypertension.
Acta anaesthesiologica Scandinavica 1995;39(7):916-21.
1995: Asgeirsson B; Grände P O; Nordström C H; Berntman L; Messeter K; Ryding E
Effects of hypotensive treatment with alpha 2-agonist and beta 1-antagonist on cerebral haemodynamics in severely head injured patients.
Acta anaesthesiologica Scandinavica 1995;39(3):347-51.
1995: Jahr J; Ekelund U; Grände P O
In vivo effects of prostacyclin on segmental vascular resistances, on myogenic reactivity, and on capillary fluid exchange in cat skeletal muscle.
Critical care medicine 1995;23(3):523-31.
1994: Grände P O; Nordström C H; Asgeirsson B
[Epoch-making ideas in care of skull injuries. New intensive care based on integrated physiology]
Läkartidningen 1994;91(50):4729-37.
1994: Asgeirsson B; Grände P O
Effects of arterial and venous pressure alterations on transcapillary fluid exchange during raised tissue pressure.
Intensive care medicine 1994;20(8):567-72.
1994: Asgeirsson B; Grände P O; Nordström C H
A new therapy of post-trauma brain oedema based on haemodynamic principles for brain volume regulation.
Intensive care medicine 1994;20(4):260-7.
1994: Grände P O; Nordström C H; Asgeirsson B
[Current alternative therapy of post-traumatic brain edema]
Nordisk medicin 1994;109(5):157-9.
1993: Roth B; Grände P O; Nilsson-Ehle P; Eliasson I
Possible role of short-term parenteral nutrition with fat emulsions for development of haemophagocytosis with multiple organ failure in a patient with traumatic brain injury.
Intensive care medicine 1993;19(2):111-4.
1992: Ekelund U; Björnberg J; Grände P O; Albert U; Mellander S
Myogenic vascular regulation in skeletal muscle in vivo is not dependent of endothelium-derived nitric oxide.
Acta physiologica Scandinavica 1992;144(2):199-207.
1992: Jahr J; Grände P O
Pulmonary and haemodynamic effects of extracorporeal circulation in the cat and the beneficial effects of prostacyclin.
Intensive care medicine 1992;18(2):118-22.
1990: Maspers M; Björnberg J; Grände P O; Mellander S
Sympathetic alpha-adrenergic control of large-bore arterial vessels, arterioles and veins, and of capillary pressure and fluid exchange in whole-organ cat skeletal muscle.
Acta physiologica Scandinavica 1990;138(4):509-21.
1990: Grände P O; Gustafsson D; Lindberg L
Effects of thiopental on resistance vessels in cat skeletal muscle.
Intensive care medicine 1990;16(6):399-404.
1989: Grände P O
Myogenic mechanisms in the skeletal muscle circulation.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1989;7(4):S47-53.
1989: Grände P O
The effects of dihydroergotamine in patients with head injury and raised intracranial pressure.
Intensive care medicine 1989;15(8):523-7.
1988: Gustafsson D; Grände P O; Borgström P; Lindberg L
Effects of calcium antagonists on myogenic and neurogenic control of resistance and capacitance vessels in cat skeletal muscle.
Journal of cardiovascular pharmacology 1988;12(4):413-22.
1988: Björnberg J; Grände P O; Maspers M; Mellander S
Site of autoregulatory reactions in the vascular bed of cat skeletal muscle as determined with a new technique for segmental vascular resistance recordings.
Acta physiologica Scandinavica 1988;133(2):199-210.
1984: Borgström P; Grände P O; Mellander S
An evaluation of the metabolic interaction with myogenic vascular reactivity during blood flow autoregulation.
Acta physiologica Scandinavica 1984;122(3):275-84.
1982: Borgström P; Grände P O; Mellander S
A mathematical description of the myogenic response in the microcirculation.
Acta physiologica Scandinavica 1982;116(4):363-76.
1981: Borgström P; Grände P O; Lindbom L
Responses of single arterioles in vivo in cat skeletal muscle to change in arterial pressure applied at different rates.
Acta physiologica Scandinavica 1981;113(2):207-12.
1981: Borgström P; Clementz L A; Grände P O
A servo-controlled roller pump for constant flow or constant pressure blood perfusion under normal pulsatile or non-pulsatile conditions.
Acta physiologica Scandinavica 1981;112(4):437-42.

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