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Patrick Grant

Research Profile

Chemicals & Drugs

Living Beings

Saccharomyces cerevisiae

Phenomena

Physiology

Transcription, Genetic

Anatomy

Chromatin

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

Co-author Network

Publications

TOP 3
Shaun D McCullough; Robert G Roeder; Xiaojiang Xu; Stefan Bekiranov; Sharon Y R Dent; Patrick A Grant
Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes.
Jaime L Miller; Patrick A Grant
The role of DNA methylation and histone modifications in transcriptional regulation in humans.
Stephen P Baker; Jennifer Phillips; Scott Anderson; Qifeng Qiu; Jeffrey Shabanowitz; M Mitchell Smith; John R Yates; Donald F Hunt; Patrick A Grant
Histone H3 Thr 45 phosphorylation is a replication-associated post-translational modification in S. cerevisiae.

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All Publications

2012: Shaun D McCullough; Robert G Roeder; Xiaojiang Xu; Stefan Bekiranov; Sharon Y R Dent; Patrick A Grant
Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(52):21319-24.
2012: Jaime L Miller; Patrick A Grant
The role of DNA methylation and histone modifications in transcriptional regulation in humans.
Sub-cellular biochemistry 2012;61():289-317.
2010: Stephen P Baker; Jennifer Phillips; Scott Anderson; Qifeng Qiu; Jeffrey Shabanowitz; M Mitchell Smith; John R Yates; Donald F Hunt; Patrick A Grant
Histone H3 Thr 45 phosphorylation is a replication-associated post-translational modification in S. cerevisiae.
Nature cell biology 2010;12(3):294-8.
2010: Shaun D McCullough; Patrick A Grant
Histone acetylation, acetyltransferases, and ataxia--alteration of histone acetylation and chromatin dynamics is implicated in the pathogenesis of polyglutamine-expansion disorders.
Advances in protein chemistry and structural biology 2010;79():165-203.
2010: Song-Ze Ding; Wolfgang Fischer; Maria Kaparakis-Liaskos; George Liechti; D Scott Merrell; Patrick A Grant; Richard L Ferrero; Sheila E Crowe; Rainer Haas; Masanori Hatakeyama; Joanna B Goldberg
Helicobacter pylori-induced histone modification, associated gene expression in gastric epithelial cells, and its implication in pathogenesis.
PloS one 2010;5(4):e9875.
2009: Houng-Wei Tsai; Patrick A Grant; Emilie F Rissman
Sex differences in histone modifications in the neonatal mouse brain.
Epigenetics : official journal of the DNA Methylation Society 2009;4(1):47-53.
2007: S P Baker; Patrick A Grant
The SAGA continues: expanding the cellular role of a transcriptional co-activator complex.
Oncogene 2007;26(37):5329-40.
2007: Jeremy A Daniel; Patrick A Grant
Multi-tasking on chromatin with the SAGA coactivator complexes.
Mutation research 2007;618(1-2):135-48.
2006: Michael S Torok; Patrick A Grant
The generation and recognition of histone methylation.
Results and problems in cell differentiation 2006;41():25-46.
2005: Stephen P Baker; Patrick A Grant
The proteasome: not just degrading anymore.
Cell 2005;123(3):361-3.
2005: Jeremy A Daniel; Marilyn G Pray-Grant; Patrick A Grant
Effector proteins for methylated histones: an expanding family.
Cell cycle (Georgetown, Tex.) 2005;4(7):919-26.
2005: Stacey J McMahon; Marilyn G Pray-Grant; David Schieltz; John R Yates; Patrick A Grant
Polyglutamine-expanded spinocerebellar ataxia-7 protein disrupts normal SAGA and SLIK histone acetyltransferase activity.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(24):8478-82.
2005: Marilyn G Pray-Grant; Jeremy A Daniel; David Schieltz; John R Yates; Patrick A Grant
Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation.
Nature 2005;433(7024):434-8.
2004: Girija Ramakrishnan; Carol A Gilchrist; Hussein Musa; Michael S Torok; Patrick A Grant; Barbara J Mann; William A Petri
Histone acetyltransferases and deacetylase in Entamoeba histolytica.
Molecular and biochemical parasitology 2004;138(2):205-16.
2004: Andrei Thomashevski; Anthony A High; Mary Drozd; Jeffrey Shabanowitz; Donald F Hunt; Patrick A Grant; Gary M Kupfer
The Fanconi anemia core complex forms four complexes of different sizes in different subcellular compartments.
The Journal of biological chemistry 2004;279(25):26201-9.
2004: Jeremy A Daniel; Michael S Torok; Zu-Wen Sun; David Schieltz; C David Allis; John R Yates; Patrick A Grant
Deubiquitination of histone H2B by a yeast acetyltransferase complex regulates transcription.
The Journal of biological chemistry 2004;279(3):1867-71.
2004: Stacey J McMahon; Yannick Doyon; Jacques Côté; Patrick A Grant
Identification and analysis of native HAT complexes.
Methods in enzymology 2004;377():154-67.
2004: Michael S Torok; Patrick A Grant
Histone acetyltransferase proteins contribute to transcriptional processes at multiple levels.
Advances in protein chemistry 2004;67():181-99.
2003: Amine Nourani; LeAnn Howe; Marilyn G Pray-Grant; Jerry L Workman; Patrick A Grant; Jacques Côté
Opposite role of yeast ING family members in p53-dependent transcriptional activation.
The Journal of biological chemistry 2003;278(21):19171-5.
2002: Marilyn G Pray-Grant; David Schieltz; Stacey J McMahon; Jennifer M Wood; Erin L Kennedy; Richard G Cook; Jerry L Workman; John R Yates; Patrick A Grant
The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway.
Molecular and cellular biology 2002;22(24):8774-86.
2002: Alexander W Bird; David Y Yu; Marilyn G Pray-Grant; Qifeng Qiu; Kirsty E Harmon; Paul C Megee; Patrick A Grant; M Mitchell Smith; Michael F Christman
Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair.
Nature 2002;419(6905):411-5.
2002: Ramakrishnan Balasubramanian; Marilyn G Pray-Grant; William Selleck; Patrick A Grant; Song Tan
Role of the Ada2 and Ada3 transcriptional coactivators in histone acetylation.
The Journal of biological chemistry 2002;277(10):7989-95.
2002: Brian D Strahl; Patrick A Grant; Scott D Briggs; Zu-Wen Sun; James R Bone; Jennifer A Caldwell; Sahana Mollah; Richard G Cook; Jeffrey Shabanowitz; Donald F Hunt; C David Allis
Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression.
Molecular and cellular biology 2002;22(5):1298-306.
2001: Patrick A Grant
A tale of histone modifications.
Genome biology 2001;2(4):REVIEWS0003.
2000: Thomas Lechner; Michael J Carrozza; Y Yu; Patrick A Grant; A Eberharter; D Vannier; Gerald Brosch; D J Stillman; D Shore; Jerry L Workman
Sds3 (suppressor of defective silencing 3) is an integral component of the yeast Sin3[middle dot]Rpd3 histone deacetylase complex and is required for histone deacetylase activity.
The Journal of biological chemistry 2000;275(52):40961-6.
2000: S John; L Howe; Stefan Tafrov; Patrick A Grant; Rolf Sternglanz; J L Workman
The something about silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF(II)30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)-FACT complex.
Genes & development 2000;14(10):1196-208.
1999: ME Massari; Patrick A Grant; Marilyn G Pray-Grant; S L Berger; Jerry L Workman; Cornelis Murre
A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex.
Molecular cell 1999;4(1):63-73.
1999: Patrick A Grant; Shelley L Berger
Histone acetyltransferase complexes.
Seminars in cell & developmental biology 1999;10(2):169-77.
1999: Patrick A Grant; A Eberharter; Sam John; Richard G Cook; B M Turner; Jerry L Workman
Expanded lysine acetylation specificity of Gcn5 in native complexes.
The Journal of biological chemistry 1999;274(9):5895-900.
1999: Patrick A Grant; Shelley L Berger; Jerry L Workman
Identification and analysis of native nucleosomal histone acetyltransferase complexes.
Methods in molecular biology (Clifton, N.J.) 1999;119():311-7.
1999: David E Sterner; Patrick A Grant; S M Roberts; Laura J Duggan; Rimma Belotserkovskaya; L A Pacella; fred winston; Jerry L Workman; Shelley L Berger
Functional organization of the yeast SAGA complex: distinct components involved in structural integrity, nucleosome acetylation, and TATA-binding protein interaction.
Molecular and cellular biology 1999;19(1):86-98.
1998: Patrick A Grant; Jerry L Workman
Transcription. A lesson in sharing?
Nature 1998;396(6710):410-1.
1998: Patrick A Grant; David Schieltz; Marilyn G Pray-Grant; John R Yates; Jerry L Workman
The ATM-related cofactor Tra1 is a component of the purified SAGA complex.
Molecular cell 1998;2(6):863-7.
1998: DJ Steger; A Eberharter; Sam John; Patrick A Grant; Jerry L Workman
Purified histone acetyltransferase complexes stimulate HIV-1 transcription from preassembled nucleosomal arrays.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):12924-9.
1998: A Eberharter; Sam John; Patrick A Grant; Rhea T Utley; Jerry L Workman
Identification and analysis of yeast nucleosomal histone acetyltransferase complexes.
Methods (San Diego, Calif.) 1998;15(4):315-21.
1998: Rhea T Utley; K Ikeda; Patrick A Grant; Jacques Côté; DJ Steger; A Eberharter; Sam John; Jerry L Workman
Transcriptional activators direct histone acetyltransferase complexes to nucleosomes.
Nature 1998;394(6692):498-502.
1998: Patrick A Grant; David Schieltz; Marilyn G Pray-Grant; DJ Steger; Joseph C Reese; John R Yates; Jerry L Workman
A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation.
Cell 1998;94(1):45-53.
1998: Patrick A Grant; David E Sterner; Laura J Duggan; Jerry L Workman; Shelley L Berger
The SAGA unfolds: convergence of transcription regulators in chromatin-modifying complexes.
Trends in cell biology 1998;8(5):193-7.
1998: DJ Steger; Rhea T Utley; Patrick A Grant; Sam John; A Eberharter; Jacques Côté; T Owen-Hughes; K Ikeda; Jerry L Workman
Regulation of transcription by multisubunit complexes that alter nucleosome structure.
Cold Spring Harbor symposia on quantitative biology 1998;63():483-91.
1997: Patrick A Grant; Laura J Duggan; Jacques Côté; S M Roberts; JE Brownell; R Candau; R Ohba; T Owen-Hughes; C David Allis; fred winston; Shelley L Berger; Jerry L Workman
Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.
Genes & development 1997;11(13):1640-50.
1996: M Vettese-Dadey; Patrick A Grant; T R Hebbes; C Crane- Robinson; C David Allis; Jerry L Workman
Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro.
The EMBO journal 1996;15(10):2508-18.