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Friedrich Grässer

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Human Herpesvirus 4

Chemicals & Drugs

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Martin Hart; Arndt Hartmann; Roopika Menon; Elke Nolte; Robert Stoehr; Jaroslaw Szczyrba; Helge Taubert; Sven Wach; Wolf Wieland; Friedrich A Grässer; Bernd Wullich
The proto-oncogene ERG is a target of microRNA miR-145 in prostate cancer.
Jaroslaw Szczyrba; Helge Taubert; Sven Wach; Wolf Wieland; Bernd Wullich; Martin Hart; Arndt Hartmann; Bastian Keck; Elisabeth Kremmer; Elke Nolte; Robert Stöhr; Celina Döll; Friedrich A Grässer
Identification of ZNF217, hnRNP-K, VEGF-A and IPO7 as targets for microRNAs that are downregulated in prostate carcinoma.
Wiyada Kwanhian; Dido Lenze; Viraphong Lulitanond; Gunter Meister; Natalie Motsch; Christoph Renner; Marianne Tinguely; Pankaj Trivedi; Julia Alles; Stephanie Barth; Celina Döll; Michael Hummel; Jochen Imig; Friedrich A Grässer
MicroRNA-142 is mutated in about 20% of diffuse large B-cell lymphoma.

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2013: Martin Hart; Arndt Hartmann; Roopika Menon; Elke Nolte; Robert Stoehr; Jaroslaw Szczyrba; Helge Taubert; Sven Wach; Wolf Wieland; Friedrich A Grässer; Bernd Wullich
The proto-oncogene ERG is a target of microRNA miR-145 in prostate cancer.
The FEBS journal 2013;280(9):2105-16.
2013: Jaroslaw Szczyrba; Helge Taubert; Sven Wach; Wolf Wieland; Bernd Wullich; Martin Hart; Arndt Hartmann; Bastian Keck; Elisabeth Kremmer; Elke Nolte; Robert Stöhr; Celina Döll; Friedrich A Grässer
Identification of ZNF217, hnRNP-K, VEGF-A and IPO7 as targets for microRNAs that are downregulated in prostate carcinoma.
International journal of cancer. Journal international du cancer 2013;132(4):775-84.
2012: Wiyada Kwanhian; Dido Lenze; Viraphong Lulitanond; Gunter Meister; Natalie Motsch; Christoph Renner; Marianne Tinguely; Pankaj Trivedi; Julia Alles; Stephanie Barth; Celina Döll; Michael Hummel; Jochen Imig; Friedrich A Grässer
MicroRNA-142 is mutated in about 20% of diffuse large B-cell lymphoma.
Cancer medicine 2012;1(2):141-55.
2012: Sven Wach; Wolf Wieland; Lars Dyrskjøt; Arif B Ekici; Elke Eltze; Friedrich A Grässer; Arndt Hartmann; Bastian Keck; Elke Nolte; Torben Ørntoft; Robert Stöhr; Jaroslaw Szczyrba; Bernd Wullich
MicroRNA profiles of prostate carcinoma detected by multiplatform microRNA screening.
International journal of cancer. Journal international du cancer 2012;130(3):611-21.
2012: Henrik Gross; Christine Hennard; Elisabeth Kremmer; Heinrich Leonhardt; Alfredo Mamiani; Ilias Masouris; Bodo Moritz; Nils Neuenkirchen; Elfriede Noessner; Dirk H Ostareck; Antje Ostareck-Lederer; Ute Stober-Grässer; Stephanie Barth; Christian Cassel; Wen Deng; Utz Fischer; Friedrich A Grässer
Binding of the heterogeneous ribonucleoprotein K (hnRNP K) to the Epstein-Barr virus nuclear antigen 2 (EBNA2) enhances viral LMP2A expression.
PloS one 2012;7(8):e42106.
2012: Natalie Motsch; Tanja Reineke; Christoph Renner; Marianne Tinguely; Jiayun Zhu; Julia Alles; Stephanie Barth; Sergio Cogliatti; Anne Dueck; Jochen Imig; Gunter Meister; Friedrich A Grässer
MicroRNA profiling of Epstein-Barr virus-associated NK/T-cell lymphomas by deep sequencing.
PloS one 2012;7(8):e42193.
2011: Stephanie Barth; Gunter Meister; Friedrich A Grässer
EBV-encoded miRNAs.
Biochimica et biophysica acta 2011;1809(11-12):631-40.
2011: Henrik Gross; Vladimir Gurtsevitch; Bin Hu; Elisabeth Kremmer; Nikolaus Mueller-Lantzsch; Elfriede Noessner; Thorsten Pfuhl; Martina Sauter; Andreas Spurk; Vivienne Willnecker; Stephanie Barth; Friedrich A Grässer
The NP9 protein encoded by the human endogenous retrovirus HERV-K(HML-2) negatively regulates gene activation of the Epstein-Barr virus nuclear antigen 2 (EBNA2).
International journal of cancer. Journal international du cancer 2011;129(5):1105-15.
2011: Jaroslaw Szczyrba; Sven Wach; Wolf Wieland; Bernd Wullich; Arndt Hartmann; Elisabeth Kremmer; Elke Nolte; Robert Stöhr; Friedrich A Grässer
Downregulation of Sec23A protein by miRNA-375 in prostate carcinoma.
Molecular cancer research : MCR 2011;9(6):791-800.
2011: Jochen Imig; Natalie Motsch; Jia Yun Zhu; Stephanie Barth; Michal Okoniewski; Tanja Reineke; Marianne Tinguely; Alberto Faggioni; Pankaj Trivedi; Gunter Meister; Christoph Renner; Friedrich A Grässer
microRNA profiling in Epstein-Barr virus-associated B-cell lymphoma.
Nucleic acids research 2011;39(5):1880-93.
2010: Henrik Gross; Stephanie Barth; Richard D Palermo; Alfredo Mamiani; Christine Hennard; Ursula Zimber-Strobl; Michelle Joanne West; Elisabeth Kremmer; Friedrich A Grässer
Asymmetric Arginine dimethylation of Epstein-Barr virus nuclear antigen 2 promotes DNA targeting.
Virology 2010;397(2):299-310.
2009: Constanze Nandy; Jan Mrázek; Heribert Stoiber; Friedrich A Grässer; Alexander Hüttenhofer; Norbert Polacek
Epstein-barr virus-induced expression of a novel human vault RNA.
Journal of molecular biology 2009;388(4):776-84.
2009: Jia Yun Zhu; Thorsten Pfuhl; Natalie Motsch; Stephanie Barth; John Nicholls; Friedrich A Grässer; Gunter Meister
Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas.
Journal of virology 2009;83(7):3333-41.
2008: Thorsten Pfuhl; Alfredo Mamiani; Matthias Dürr; Susanne Welter; Johanna Stieber; Jasmin Ankara; Michael Liss; Thomas Dobner; Andrea Schmitt; Peter Falkai; Elisabeth Kremmer; Volker Jung; Stephanie Barth; Friedrich A Grässer
The LARK/RBM4a protein is highly expressed in cerebellum as compared to cerebrum.
Neuroscience letters 2008;444(1):11-5.
2008: Stephanie Barth; Thorsten Pfuhl; Alfredo Mamiani; Claudia Ehses; Klaus Roemer; Elisabeth Kremmer; Christoph Jäker; Julia Höck; Gunter Meister; Friedrich A Grässer
Epstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5.
Nucleic acids research 2008;36(2):666-75.
2007: Natalie Motsch; Thorsten Pfuhl; Jan Mrazek; Stephanie Barth; Friedrich A Grässer
Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) induces the expression of the cellular microRNA miR-146a.
RNA biology 2007;4(3):131-7.
2007: Jan Mrázek; Simone B Kreutmayer; Friedrich A Grässer; Norbert Polacek; Alexander Hüttenhofer
Subtractive hybridization identifies novel differentially expressed ncRNA species in EBV-infected human B cells.
Nucleic acids research 2007;35(10):e73.
2006: C Hennard; T Pfuhl; Maike Buettner; K-F Becker; T Knöfel; Jaap Middeldorp; Elisabeth Kremmer; Gerald Niedobitek; Friedrich A Grässer
The antibody 2B4 directed against the Epstein-Barr virus (EBV)-encoded nuclear antigen 1 (EBNA1) detects MAGE-4: implications for studies on the EBV association of human cancers.
The Journal of pathology 2006;209(4):430-5.
2005: Thorsten Pfuhl; Matthias Dürr; Andreas Spurk; Björn Schwalbert; Ruth Nord; Josef Mysliwietz; Elisabeth Kremmer; Friedrich A Grässer
Biochemical characterisation of the proteins encoded by the DiGeorge critical region 6 (DGCR6) genes.
Human genetics 2005;117(1):70-80.
2005: Sébastien Pfeffer; Alain Sewer; Mariana Lagos-Quintana; Robert Sheridan; Chris Sander; Friedrich A Grässer; Linda F van Dyk; Kiong Ho; Stewart Shuman; Minchen Chien; James J Russo; Jingyue Ju; Glenn Randall; Brett D Lindenbach; Charles M Rice; Viviana Simon; David D Ho; Mihaela Zavolan; Thomas Tuschl
Identification of microRNAs of the herpesvirus family.
Nature methods 2005;2(4):269-76.
2005: Bernd F.M. Romeike; Andrea Böckeler; Elisabeth Kremmer; Peter Sommer; Christoph Krick; Friedrich A Grässer
Immunohistochemical detection of dUTPase in intracranial tumors.
Pathology, research and practice 2005;201(11):727-32.
2004: Sébastien Pfeffer; Mihaela Zavolan; Friedrich A Grässer; Minchen Chien; James J Russo; Jingyue Ju; Bino John; Anton J Enright; Debora Marks; Chris Sander; Thomas Tuschl
Identification of virus-encoded microRNAs.
Science (New York, N.Y.) 2004;304(5671):734-6.
2004: John Nicholls; Peter Hahn; Elisabeth Kremmer; Thomas Fröhlich; Georg J Arnold; Jonathan S T Sham; Dora L W Kwong; Friedrich A Grässer
Detection of wild type and deleted latent membrane protein 1 (LMP1) of Epstein-Barr virus in clinical biopsy material.
Journal of virological methods 2004;116(1):79-88.
2003: Stephanie Barth; Michael Liss; Marc D Voss; Thomas Dobner; Utz Fischer; Gunter Meister; Friedrich A Grässer
Epstein-Barr virus nuclear antigen 2 binds via its methylated arginine-glycine repeat to the survival motor neuron protein.
Journal of virology 2003;77(8):5008-13.
2002: Johann Fleischmann; Elisabeth Kremmer; John Greenspan; Friedrich A Grässer; Gerald Niedobitek
Expression of viral and human dUTPase in Epstein-Barr virus-associated diseases.
Journal of medical virology 2002;68(4):568-73.
2002: Johannes Prudlo; Anja Fischer; Michaela Läpple; Anja Müller; Katrin Neubert; Christian A Gericke; Albert C Ludolph; Friedrich A Grässer; Christian Sauder
Seroprevalence of Borna disease virus antibodies is not increased in patients with amyotrophic lateral sclerosis.
Journal of neurology 2002;249(10):1462-3.
2002: Annette Hille; Akua Badu-Antwi; Daniela Holzer; Friedrich A Grässer
Lysine residues of Epstein-Barr virus-encoded nuclear antigen 2 do not confer secondary modifications via ubiquitin or SUMO-like proteins but modulate transcriptional activation.
The Journal of general virology 2002;83(Pt 5):1037-42.
2002: Christine Bauer; Nicole Brass; Isabel Diesinger; Klaus Kayser; Friedrich A Grässer; Eckart Meese
Overexpression of the eukaryotic translation initiation factor 4G (eIF4G-1) in squamous cell lung carcinoma.
International journal of cancer. Journal international du cancer 2002;98(2):181-5.
2001: Friedrich A Grässer; Bernd F.M. Romeike; Gerald Niedobitek; J Nicholls; Elisabeth Kremmer
dUTPase in human neoplastic cells as a potential target for therapeutic intervention.
Current protein & peptide science 2001;2(4):349-60.
2001: M D Voss; A Hille; S Barth; A Spurk; F Hennrich; Daniela Holzer; Nikolaus Mueller-Lantzsch; Elisabeth Kremmer; Friedrich A Grässer
Functional cooperation of Epstein-Barr virus nuclear antigen 2 and the survival motor neuron protein in transactivation of the viral LMP1 promoter.
Journal of virology 2001;75(23):11781-90.
2001: J Nicholls; Elisabeth Kremmer; CA Meseda; Mike Mackett; Peter Hahn; Margaret L Gulley; A Brink; Lode J Swinnen; J Greenspan; Y De Souza; Friedrich A Grässer; Jonathan S T Sham; Mun-Hon Ng; John R Arrand
Comparative analysis of the expression of the Epstein-Barr virus (EBV) anti-apoptotic gene BHRF1 in nasopharyngeal carcinoma and EBV-related lymphoid diseases.
Journal of medical virology 2001;65(1):105-13.
2001: Peter Hahn; EV Novikova; L Scherback; C Janik; OA Pavlish; V Arkhipov; J Nicholls; N Müller-Lantzsch; Vladimir Gurtsevitch; Friedrich A Grässer
The LMP1 gene isolated from Russian nasopharyngeal carcinoma has no 30-bp deletion.
International journal of cancer. Journal international du cancer 2001;91(6):815-21.
1999: Johann Fleischmann; Elisabeth Kremmer; S Müller; Peter Sommer; Thomas Kirchner; Gerald Niedobitek; Friedrich A Grässer
Expression of deoxyuridine triphosphatase (dUTPase) in colorectal tumours.
International journal of cancer. Journal international du cancer 1999;84(6):614-7.
1999: A T Grundhoff; Elisabeth Kremmer; Ozlem Türeci; A Glieden; C Gindorf; J Atz; Nikolaus Mueller-Lantzsch; W H Schubach; Friedrich A Grässer
Characterization of DP103, a novel DEAD box protein that binds to the Epstein-Barr virus nuclear proteins EBNA2 and EBNA3C.
The Journal of biological chemistry 1999;274(27):19136-44.
1999: Elisabeth Kremmer; Peter Sommer; Daniela Holzer; S A Galetsky; V A Molochkov; Vladimir Gurtsevitch; C Winkelmann; Renate Lisner; Gerald Niedobitek; Friedrich A Grässer
Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) ORF54 encodes a functional dUTPase expressed in the lytic replication cycle.
The Journal of general virology 1999;80 ( Pt 5)():1305-10.
1999: N Fischer; M D Voss; Nikolaus Mueller-Lantzsch; Friedrich A Grässer
A potential NES of the Epstein-Barr virus nuclear antigen 1 (EBNA1) does not confer shuttling.
FEBS letters 1999;447(2-3):311-4.
1999: N Fischer; B Kopper; Norbert Graf; J R Schlehofer; Friedrich A Grässer; Nikolaus Mueller-Lantzsch
Functional analysis of different LMP1 proteins isolated from Epstein-Barr virus-positive carriers.
Virus research 1999;60(1):41-54.
1999: Martin Hafner; Martina Vockerodt; O Weber; K Hell; Jürgen Wolf; B Haier; Friedrich A Grässer; N Müller-Lantzsch; E Kieff; Volker Diehl; Hans Tesch
Expression of epstein-barr virus nuclear antigen 1 is associated with enhanced expression of CD25 in the Hodgkin cell line L428.
Journal of virology 1999;73(2):1630-6.
1998: John M Nicholls; Peter Sommer; Elisabeth Kremmer; K S Ong; K Fung; J M Lee; M H Ng; Friedrich A Grässer
A new lytic antibody, 7D6, detects Epstein-Barr virus dUTPase in nonkeratinizing undifferentiated nasopharyngeal carcinomas.
Laboratory investigation; a journal of technical methods and pathology 1998;78(8):1031-2.
1998: Anja Mehl-Lautscham; N Fischer; M Rowe; F Hartmann; Heiner Daus; Lorenz Trümper; Michael Pfreundschuh; N Müller-Lantzsch; Friedrich A Grässer
Isolation and analysis of two strongly transforming isoforms of the Epstein-Barr-Virus(EBV)-encoded latent membrane protein-1 (LMP1) from a single Hodgkin's lymphoma.
International journal of cancer. Journal international du cancer 1998;76(2):194-200.
1997: Gerald Niedobitek; Elisabeth Kremmer; Hermann Herbst; L Whitehead; Christopher W Dawson; Edith Niedobitek; C von Ostau; N Rooney; Friedrich A Grässer; Lawrence S Young
Immunohistochemical detection of the Epstein-Barr virus-encoded latent membrane protein 2A in Hodgkin's disease and infectious mononucleosis.
Blood 1997;90(4):1664-72.
1997: N Fischer; Elisabeth Kremmer; G Lautscham; Nikolaus Mueller-Lantzsch; Friedrich A Grässer
Epstein-Barr virus nuclear antigen 1 forms a complex with the nuclear transporter karyopherin alpha2.
The Journal of biological chemistry 1997;272(7):3999-4005.
1997: Elisabeth Kremmer; Peter Sommer; Friedrich A Grässer
Epstein-Barr virus-encoded deoxyuridine triphosphate nucleotidohydrolase (dUTPase): a potential target for drug therapy.
Transplantation proceedings 1997;29(1-2):812-4.
1996: Peter Sommer; Elisabeth Kremmer; S Bier; S König; P Zalud; Michael Zeppezauer; J F Jones; Nikolaus Mueller-Lantzsch; Friedrich A Grässer
Cloning and expression of the Epstein-Barr virus-encoded dUTPase: patients with acute, reactivated or chronic virus infection develop antibodies against the enzyme.
The Journal of general virology 1996;77 ( Pt 11)():2795-805.
1996: C Sauder; A Müller; Beatrice Cubitt; Jens Mayer; J Steinmetz; W Trabert; B Ziegler; K Wanke; Nikolaus Mueller-Lantzsch; Juan Carlos de la Torre; Friedrich A Grässer
Detection of Borna disease virus (BDV) antibodies and BDV RNA in psychiatric patients: evidence for high sequence conservation of human blood-derived BDV RNA.
Journal of virology 1996;70(11):7713-24.
1996: Juan Carlos de la Torre; Daniel Gonzalez-Dunia; Beatrice Cubitt; Margaret Mallory; Nikolaus Mueller-Lantzsch; Friedrich A Grässer; Lawrence A Hansen; Eliezer Masliah
Detection of borna disease virus antigen and RNA in human autopsy brain samples from neuropsychiatric patients.
Virology 1996;223(2):272-82.
1996: S Fruehling; S K Lee; R Herrold; B Frech; G Laux; Elisabeth Kremmer; Friedrich A Grässer; Richard Longnecker
Identification of latent membrane protein 2A (LMP2A) domains essential for the LMP2A dominant-negative effect on B-lymphocyte surface immunoglobulin signal transduction.
Journal of virology 1996;70(9):6216-26.
1996: C Sauder; N Götzinger; W H Schubach; G C Horvath; Elisabeth Kremmer; A Krebs; S König; Ursula Zimber-Strobl; Nikolaus Mueller-Lantzsch; Friedrich A Grässer
Mutational analysis of the Epstein-Barr virus nuclear antigen 2 by far-Western blotting and DNA-binding studies.
The Journal of general virology 1996;77 ( Pt 5)():991-6.
1996: Paul G Murray; Gerald Niedobitek; Elisabeth Kremmer; Friedrich A Grässer; G M Reynolds; AT Cruchley; DM Williams; N Müller-Lantzsch; Lawrence S Young
In situ detection of the Epstein-Barr virus-encoded nuclear antigen 1 in oral hairy leukoplakia and virus-associated carcinomas.
The Journal of pathology 1996;178(1):44-7.
1996: B Winkelspecht; Friedrich A Grässer; H W Pees; Nikolaus Mueller-Lantzsch
Anti-EBNA1/anti-EBNA2 ratio decreases significantly in patients with progression of HIV infection.
Archives of virology 1996;141(5):857-64.
1994: Friedrich A Grässer; Paul G Murray; E Kremmer; K Klein; K Remberger; W Feiden; G Reynolds; Gerald Niedobitek; Lawrence S Young; Nikolaus Mueller-Lantzsch
Monoclonal antibodies directed against the Epstein-Barr virus-encoded nuclear antigen 1 (EBNA1): immunohistologic detection of EBNA1 in the malignant cells of Hodgkin's disease.
Blood 1994;84(11):3792-8.
1994: C Sauder; P Haiss; Friedrich A Grässer; Ursula Zimber-Strobl; Nikolaus Mueller-Lantzsch
DNA-binding studies of the Epstein-Barr virus nuclear antigen 2 (EBNA-2): evidence for complex formation by latent membrane protein gene promoter-binding proteins in EBNA-2-positive cell lines.
The Journal of general virology 1994;75 ( Pt 11)():3067-79.
1993: Friedrich A Grässer; C Sauder; P Haiss; A Hille; S König; S Göttel; E Kremmer; H P Leinenbach; Michael Zeppezauer; Nikolaus Mueller-Lantzsch
Immunological detection of proteins associated with the Epstein-Barr virus nuclear antigen 2A.
Virology 1993;195(2):550-60.
1993: Nikolaus Mueller-Lantzsch; M Sauter; A Weiskircher; K Kramer; B Best; M Buck; Friedrich A Grässer
Human endogenous retroviral element K10 (HERV-K10) encodes a full-length gag homologous 73-kDa protein and a functional protease.
AIDS research and human retroviruses 1993;9(4):343-50.
1993: A Hille; K Klein; S Bäumler; Friedrich A Grässer; Nikolaus Mueller-Lantzsch
Expression of Epstein-Barr virus nuclear antigen 1,2A and 2B in the baculovirus expression system: serological evaluation of human antibodies to these proteins.
Journal of medical virology 1993;39(3):233-41.
1993: Ursula Zimber-Strobl; E Kremmer; Friedrich A Grässer; Gabriele Marschall; Gerhard Laux; Georg W Bornkamm
The Epstein-Barr virus nuclear antigen 2 interacts with an EBNA2 responsive cis-element of the terminal protein 1 gene promoter.
The EMBO journal 1993;12(1):167-75.
1992: C Garrido; Friedrich A Grässer; Joseph S Lipsick; Dominique Stehelin; Simon Saule
Protein truncation is not required for c-myb proto-oncogene activity in neuroretina cells.
Journal of virology 1992;66(11):6773-6.
1992: H F Chen; S Kevan-Jah; K O Suentzenich; Friedrich A Grässer; Nikolaus Mueller-Lantzsch
Expression of the Epstein-Barr virus latent membrane protein (LMP) in insect cells and detection of antibodies in human sera against this protein.
Virology 1992;190(1):106-15.
1992: Friedrich A Grässer; S Göttel; P Haiss; Brigitte Boldyreff; Olaf-Georg Issinger; Nikolaus Mueller-Lantzsch
Phosphorylation of the Epstein-Barr virus nuclear antigen 2.
Biochemical and biophysical research communications 1992;186(3):1694-701.
1992: Friedrich A Grässer; K LaMontagne; L Whittaker; S Stohr; Joseph S Lipsick
A highly conserved cysteine in the v-Myb DNA-binding domain is essential for transformation and transcriptional trans-activation.
Oncogene 1992;7(5):1005-9.
1992: U Stober-Grässer; B Brydolf; X Bin; Friedrich A Grässer; R A Firtel; Joseph S Lipsick
The Myb DNA-binding domain is highly conserved in Dictyostelium discoideum.
Oncogene 1992;7(3):589-96.
1992: Friedrich A Grässer; S König
Phosphorylation of SV40 large T antigen at threonine residues results in conversion to a lower apparent molecular weight form.
Archives of virology 1992;126(1-4):313-20.
1991: Friedrich A Grässer; T Graf; Joseph S Lipsick
Protein truncation is required for the activation of the c-myb proto-oncogene.
Molecular and cellular biology 1991;11(8):3987-96.
1991: Friedrich A Grässer; P Haiss; S Göttel; Nikolaus Mueller-Lantzsch
Biochemical characterization of Epstein-Barr virus nuclear antigen 2A.
Journal of virology 1991;65(7):3779-88.
1988: Friedrich A Grässer; K H Scheidtmann; P T Tuazon; J A Traugh; Gernot Walter
In vitro phosphorylation of SV40 large T antigen.
Virology 1988;165(1):13-22.
1987: Friedrich A Grässer; K Mann; Gernot Walter
Removal of serine phosphates from simian virus 40 large T antigen increases its ability to stimulate DNA replication in vitro but has no effect on ATPase and DNA binding.
Journal of virology 1987;61(11):3373-80.