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Silvana Grasso

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Roberta Ettari; Silvana Grasso; Giovanni Grazioso; Nicola Micale; Tanja Schirmeister; Floriana Bova; Maria Zappalà
Synthesis and molecular modeling studies of derivatives of a highly potent peptidomimetic vinyl ester as falcipain-2 inhibitors.
Mohammad S Qneibi; Silvana Grasso; Nicola Micale; Li Niu
Mechanism of inhibition of GluA2 AMPA receptor channel opening by 2,3-benzodiazepine derivatives: functional consequences of replacing a 7,8-methylenedioxy with a 7,8-ethylenedioxy moiety.
Roberta Ettari; Silvana Grasso; Cornelia Heindl; Nicola Micale; Tanja Schirmeister; Cinzia Bonaccorso; Maria Luisa Calabrò; Maria Zappalà
Development of novel peptidomimetics containing a vinyl sulfone moiety as proteasome inhibitors.

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2012: Roberta Ettari; Silvana Grasso; Giovanni Grazioso; Nicola Micale; Tanja Schirmeister; Floriana Bova; Maria Zappalà
Synthesis and molecular modeling studies of derivatives of a highly potent peptidomimetic vinyl ester as falcipain-2 inhibitors.
ChemMedChem 2012;7(9):1594-600.
2012: Mohammad S Qneibi; Silvana Grasso; Nicola Micale; Li Niu
Mechanism of inhibition of GluA2 AMPA receptor channel opening by 2,3-benzodiazepine derivatives: functional consequences of replacing a 7,8-methylenedioxy with a 7,8-ethylenedioxy moiety.
Biochemistry 2012;51(8):1787-95.
2011: Roberta Ettari; Silvana Grasso; Cornelia Heindl; Nicola Micale; Tanja Schirmeister; Cinzia Bonaccorso; Maria Luisa Calabrò; Maria Zappalà
Development of novel peptidomimetics containing a vinyl sulfone moiety as proteasome inhibitors.
ChemMedChem 2011;6(7):1228-37.
2011: Roberta Ettari; Maria Zappalà; Nicola Micale; Giovanni Grazioso; Salvatore Giofrè; Tanja Schirmeister; Silvana Grasso
Peptidomimetics containing a vinyl ketone warhead as falcipain-2 inhibitors.
European journal of medicinal chemistry 2011;46(6):2058-65.
2010: Floriana Bova; Roberta Ettari; Nicola Micale; Caterina Carnovale; Tanja Schirmeister; Christoph Gelhaus; Joachim Grötzinger; Silvana Grasso; Maria Zappalà
Constrained peptidomimetics as antiplasmodial falcipain-2 inhibitors.
Bioorganic & medicinal chemistry 2010;18(14):4928-38.
2010: Roberta Ettari; Maria Zappalà; Nicola Micale; Tanja Schirmeister; Christoph Gelhaus; Matthias Leippe; Astrid Evers; Silvana Grasso
Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain.
European journal of medicinal chemistry 2010;45(7):3228-33.
2010: Roberta Ettari; Floriana Bova; Maria Zappalà; Silvana Grasso; Nicola Micale
Falcipain-2 inhibitors.
Medicinal research reviews 2010;30(1):136-67.
2009: Nicola Micale; Roberta Ettari; Tanja Schirmeister; Astrid Evers; Christoph Gelhaus; Joachim Grötzinger; Maria Zappalà; Silvana Grasso
Novel 2H-isoquinolin-3-ones as antiplasmodial falcipain-2 inhibitors.
Bioorganic & medicinal chemistry 2009;17(18):6505-11.
2009: Roberta Ettari; Nicola Micale; Tanja Schirmeister; Christoph Gelhaus; Joachim Grötzinger; Emanuela Nizi; Maria Emilia Di Francesco; Silvana Grasso; Maria Zappalà
Novel peptidomimetics containing a vinyl ester moiety as highly potent and selective falcipain-2 inhibitors.
Journal of medicinal chemistry 2009;52(7):2157-60.
2009: Maria Luisa Calabrò; Daniela Raneri; Paola Ficarra; Tiziana Mennini; Simona Colleoni; Giovanni Grazioso; Nicola Micale; Maria Zappalà; Silvana Grasso
Synthesis, chiral resolution and pharmacological evaluation of a 2,3-benzodiazepine-derived noncompetitive AMPA receptor antagonist.
ChemMedChem 2009;4(3):415-20.
2008: Roberta Ettari; Emanuela Nizi; Maria Emilia Di Francesco; Nicola Micale; Silvana Grasso; Maria Zappalà; Radim Vicík; Tanja Schirmeister
Nonpeptidic vinyl and allyl phosphonates as falcipain-2 inhibitors.
ChemMedChem 2008;3(7):1030-3.
2008: Nicola Micale; Simona Colleoni; Giovanna Postorino; Alessia Pellicanò; Maria Zappalà; John Lazzaro; Valentina Diana; Alfredo Cagnotto; Tiziana Mennini; Silvana Grasso
Structure-activity study of 2,3-benzodiazepin-4-ones noncompetitive AMPAR antagonists: identification of the 1-(4-amino-3-methylphenyl)-3,5-dihydro-7,8-ethylenedioxy-4H-2,3-benzodiazepin-4-one as neuroprotective agent.
Bioorganic & medicinal chemistry 2008;16(5):2200-11.
2008: Roberta Ettari; Emanuela Nizi; Maria Emilia Di Francesco; Marie-Adrienne Dude; Gabriele Pradel; Radim Vicík; Tanja Schirmeister; Nicola Micale; Silvana Grasso; Maria Zappalà
Development of peptidomimetics with a vinyl sulfone warhead as irreversible falcipain-2 inhibitors.
Journal of medicinal chemistry 2008;51(4):988-96.
2008: Mark Ritz; Nicola Micale; Silvana Grasso; Li Niu
Mechanism of inhibition of the GluR2 AMPA receptor channel opening by 2,3-benzodiazepine derivatives.
Biochemistry 2008;47(3):1061-9.
2007: Maria Luisa Calabrò; Daniela Raneri; Paola Ficarra; Guido Ferreri; Giovambattista De Sarro; Giuseppe Bruno; Maria Zappalà; Nicola Micale; Silvana Grasso
Enantioseparation, absolute configuration determination, and anticonvulsant activity of (+/-)-1-(4-aminophenyl)-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-benzodiazepin-4-one.
Chirality 2007;19(1):16-21.
2006: Nicola Micale; Alan P Kozikowski; Roberta Ettari; Silvana Grasso; Maria Zappalà; Jong-Jin Jeong; Ajay Kumar; Manjit Hanspal; Athar H Chishti
Novel peptidomimetic cysteine protease inhibitors as potential antimalarial agents.
Journal of medicinal chemistry 2006;49(11):3064-7.
2006: Nicola Micale; Giovanna Postorino; Silvana Grasso; Maria Zappalà; Giuseppe Zuccalà; Guido Ferreri; Giovambattista De Sarro
Synthesis of novel 3-(alkylcarbamoyl)-2-aryl-1,2-dihydro-6,7-(methylenedioxy)-3H-quinazolin-4-ones as anticonvulsant agents.
Chemistry & biodiversity 2006;3(3):304-11.
2006: Maria Zappalà; Giovanna Postorino; Nicola Micale; Salvatore Caccamese; Nunziatina Parrinello; Giovanni Grazioso; Gabriella Roda; Frank S Menniti; Giovambattista De Sarro; Silvana Grasso
Synthesis, chiral resolution, and enantiopharmacology of a potent 2,3-benzodiazepine derivative as noncompetitive AMPA receptor antagonist.
Journal of medicinal chemistry 2006;49(2):575-81.
2006: Maria Zappalà; Alessia Pellicanò; Nicola Micale; Frank S Menniti; Guido Ferreri; Giovambattista De Sarro; Silvana Grasso; Carlo De Micheli
New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists.
Bioorganic & medicinal chemistry letters 2006;16(1):167-70.
2005: Nicola Micale; Maria Zappalà; Giuseppe Zuccalà; Frank S Menniti; Guido Ferreri; Giovambattista De Sarro; Silvana Grasso
Synthesis of 2-semicarbazonomethyl-4,5-methylenedioxyphenylacetic acids as anticonvulsant agents.
Farmaco (Società chimica italiana : 1989) 2005;60(3):231-5.
2004: Nicola Micale; Giovambattista De Sarro; Guido Ferreri; Maria Zappalá; Silvana Grasso; Giulia Puia; Carlo De Micheli
Design of 1-substituted 2-arylmethyl-4,5-methylenedioxybenzene derivatives as antiseizure agents.
Bioorganic & medicinal chemistry 2004;12(13):3703-9.
2003: Maria Zappalà; Silvana Grasso; Nicola Micale; Giuseppe Zuccalà; Frank S Menniti; Guido Ferreri; Giovambattista De Sarro; Carlo De Micheli
1-aryl-6,7-methylenedioxy-3H-quinazolin-4-ones as anticonvulsant agents.
Bioorganic & medicinal chemistry letters 2003;13(24):4427-30.
2003: Nicola Micale; Maria Zappalà; Silvana Grasso
Synthesis and cytotoxic activity of 1,3-benzodioxole derivatives. Note II.
Farmaco (Società chimica italiana : 1989) 2003;58(5):351-5.
2003: Silvana Grasso; Nicola Micale; Maria Zappalà; Alessandro Galli; Chiara Costagli; Frank S Menniti; Carlo De Micheli
Characterization of the mechanism of anticonvulsant activity for a selected set of putative AMPA receptor antagonists.
Bioorganic & medicinal chemistry letters 2003;13(3):443-6.
2002: Nicola Micale; Maria Zappalà; Silvana Grasso
Synthesis and antitumor activity of 1,3-benzodioxole derivatives.
Farmaco (Società chimica italiana : 1989) 2002;57(10):853-9.
2002: Nicola Micale; Maria Zappalà; Silvana Grasso; Giulia Puja; Giovambattista De Sarro; Guido Ferreri; Angela De Sarro; Lucio Toma; Carlo De Micheli
Novel potent AMPA/kainate receptor antagonists: synthesis and anticonvulsant activity of a series of 2-[(4-alkylsemicarbazono)-(4-amino-phenyl)methyl]-4,5-methylenedioxyphenylacetic acid alkyl esters.
Journal of medicinal chemistry 2002;45(20):4433-42.
2001: Maria Zappalà; Silvana Grasso; Nicola Micale; S Polimeni; Carlo De Micheli
Synthesis and structure-activity relationships of 2,3-benzodiazepines as AMPA receptor antagonists.
Mini reviews in medicinal chemistry 2001;1(3):243-53.
2001: Francesco Nicoló; Giuseppe Bruno; R Scopelliti; Silvana Grasso; A Rao; Maria Zappalá
7-Chloro-1-(2,6-difluorophenyl)-1H,3H-thiazolo.
Acta crystallographica. Section C, Crystal structure communications 2001;57(Pt 5):572-4.
2001: Silvana Grasso; Giovambattista De Sarro; Angela De Sarro; Nicola Micale; S Polimeni; Maria Zappalà; Giulia Puia; Mario Baraldi; Carlo De Micheli
Synthesis and anticonvulsant activity of novel and potent 1-aryl-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-benzodiazepin-4-ones.
Bioorganic & medicinal chemistry letters 2001;11(4):463-6.
2000: Silvana Grasso; Nicola Micale; Anna Maria Monforte; Pietro Monforte; S Polimeni; Maria Zappalà
Synthesis and in vitro antitumour activity evaluation of 1-aryl-1H,3H-thiazolo[4,3-b]quinazolines.
European journal of medicinal chemistry 2000;35(12):1115-9.
2000: Silvana Grasso; Giovambattista De Sarro; Angela De Sarro; Nicola Micale; Maria Zappalà; G Puja; Mario Baraldi; Carlo De Micheli
Synthesis and anticonvulsant activity of novel and potent 6,7-methylenedioxyphthalazin-1(2H)-ones.
Journal of medicinal chemistry 2000;43(15):2851-9.
1999: Silvana Grasso; Giovambattista De Sarro; Angela De Sarro; Nicola Micale; Maria Zappalà; Giulia Puia; Mario Baraldi; Carlo De Micheli
Synthesis and anticonvulsant activity of novel and potent 2,3-benzodiazepine AMPA/kainate receptor antagonists.
Journal of medicinal chemistry 1999;42(21):4414-21.
1999: Alba Chimirri; Silvana Grasso; Pietro Monforte; Angela Rao; Maria Zappalà; Anna Maria Monforte; Christophe Pannecouque; Myriam Witvrouw; Jan Balzarini; Erik De Clercq
Synthesis and biological activity of novel 1H,3H-thiazolo[3,4-a]benzimidazoles: non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors.
Antiviral chemistry & chemotherapy 1999;10(4):211-7.
1999: Angela De Sarro; Giovambattista De Sarro; Rosaria Gitto; Silvana Grasso; Nicola Micale; Maria Zappalà
Synthesis and anticonvulsant activity of new 2,3-benzodiazepines as AMPA receptor antagonists.
Farmaco (Società chimica italiana : 1989) 1999;54(3):178-87.
1998: Alba Chimirri; Silvana Grasso; Anna Maria Monforte; Pietro Monforte; Angela Rao; Maria Zappalà; G Bruno; F Nicolò; Christophe Pannecouque; Myriam Witvrouw; Erik De Clercq
Synthesis, structure and in vitro anti-human immunodeficiency virus activity of novel 3-methyl-1H,3H-thiazolo[3,4-a]benzimidazoles.
Antiviral chemistry & chemotherapy 1998;9(5):431-8.
1998: Angela De Sarro; Giovambattista De Sarro; Rosaria Gitto; Silvana Grasso; Nicola Micale; Silvana Quartarone; Maria Zappalà
7,8-Methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel AMPA receptor antagonists.
Bioorganic & medicinal chemistry letters 1998;8(8):971-6.
1997: Alba Chimirri; Silvana Grasso; Anna Maria Monforte; Pietro Monforte; Angela Rao; Maria Zappalà; G Bruno; F Nicolò; R Scopelliti
Anti-HIV agents. V. Synthesis, structure and in vitro anti-HIV activity of novel 1H,3H-naphtho[2',3':4,5]imidazo[1,2-c]thiazoles.
Farmaco (Società chimica italiana : 1989) 1997;52(11):673-7.
1997: Alba Chimirri; Giovambattista De Sarro; Angela De Sarro; Rosaria Gitto; Silvana Grasso; Silvana Quartarone; Maria Zappalà; P Giusti; V Libri; Andrew Constanti; A G Chapman
1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists.
Journal of medicinal chemistry 1997;40(8):1258-69.
1996: Alba Chimirri; Silvana Grasso; C Molica; Anna Maria Monforte; Pietro Monforte; Maria Zappalà; R Scopelliti
Anti-HIV agents. IV. Synthesis and in vitro anti-HIV activity of novel 1-(2,6-difluorophenyl)-1H,3H-thiazolo[3,4-a]benzimidazoles.
Farmaco (Società chimica italiana : 1989) 1996;51(4):279-82.
1996: Silvana Grasso; C Molica; Anna Maria Monforte; Pietro Monforte; Maria Zappalà; M Rizzo
Synthesis and in vitro antitumor activity evaluation of 9-substituted 1,2,3,4-tetrahydrocarbazoles.
Farmaco (Società chimica italiana : 1989) 1996;51(4):269-74.
1996: Alba Chimirri; Silvana Grasso; Anna Maria Monforte; Angela Rao; M Zappala
Synthesis and antitumor activity evaluation of Delta2-1,2,4-oxadiazoline derivatives.
Farmaco (Società chimica italiana : 1989) 1996;51(2):125-9.
1995: Giovambattista De Sarro; Alba Chimirri; Angela De Sarro; Rosaria Gitto; Silvana Grasso; P Giusti; A G Chapman
GYKI 52466 and related 2,3-benzodiazepines as anticonvulsant agents in DBA/2 mice.
European journal of pharmacology 1995;294(2-3):411-22.
1995: Alba Chimirri; Silvana Grasso; Anna Maria Monforte; Pietro Monforte; Maria Zappalà
Novel pyrrolo- and thiazolo-imidazoles.
Farmaco (Società chimica italiana : 1989) 1995;50(6):401-4.
1995: Silvana Grasso; C Molica; Anna Maria Monforte; Pietro Monforte; Maria Zappalà; Maria T Monforte; Ada Trovato
Synthesis and antihypertensive activity evaluation of indole derivatives N-acetamido substituted.
Farmaco (Società chimica italiana : 1989) 1995;50(2):113-7.
1995: Angela De Sarro; D Ammendola; M Zappala; Silvana Grasso; G B De Sarro
Relationship between structure and convulsant properties of some beta-lactam antibiotics following intracerebroventricular microinjection in rats.
Antimicrobial agents and chemotherapy 1995;39(1):232-7.
1994: Alba Chimirri; Rosaria Gitto; Silvana Grasso; Anna Maria Monforte; Maria Zappalà
Synthesis and antitumor activity evaluation of 1-[(arylidene)amino]adamantanes.
Farmaco (Società chimica italiana : 1989) 1994;49(10):649-51.
1994: Angela De Sarro; Giovambattista De Sarro; Alba Chimirri; Silvana Grasso; Anna Maria Monforte; Maria Zappalà
Anticonvulsant activity of pyrrolo[1',2':1,2]imidazo[4,5-b]pyridines, pyrrolo[2',1':2,3]imidazo[4,5-c] pyridines and pyrrolo[2,1-f]purines in DBA/2 mice.
General pharmacology 1994;25(5):1027-31.
1994: Alba Chimirri; Silvana Grasso; Anna Maria Monforte; Pietro Monforte; Maria Zappalà; Angelo Carotti
Synthesis and in vitro anti-HIV activity of novel delta 2-1,2,4-oxadiazoline derivatives.
Farmaco (Società chimica italiana : 1989) 1994;49(7-8):509-11.
1994: Alba Chimirri; Silvana Grasso; A M Montforte; Pietro Monforte; Maria Zappalà
Anti-HIV agents. III. Synthesis and in vitro anti-HIV activity of novel 1H,3H-thiazolo[3,4-a]imidazo[4,5-b]pyridines.
Farmaco (Società chimica italiana : 1989) 1994;49(5):345-8.
1994: Alba Chimirri; Silvana Grasso; A M Montforte; P Montforte; Maria Zappalà; Angelo Carotti
Structure-activity relationships of antitumor thiazolo[3,4-a]benzimidazole derivatives.
Farmaco (Società chimica italiana : 1989) 1994;49(5):337-44.
1994: Maria Gabriella Vigorita; Silvana Grasso; Maria Zappalà; Rosaria Ottanà; Maria T Monforte; R Barbera; Ada Trovato
Aminopyrazinyl derivatives: synthesis and evaluation of antiinflammatory and related activities.
Farmaco (Società chimica italiana : 1989) 1994;49(4):271-6.
1994: Alba Chimirri; Rosaria Gitto; Silvana Grasso; Maria Zappalà; Angela De Sarro; G Battista De Sarro
Structure-activity relationships in thienodiazepine and benzodiazepine derivatives.
Farmaco (Società chimica italiana : 1989) 1994;49(3):193-6.
1993: Alba Chimirri; Silvana Grasso; Pietro Monforte; Maria Zappalà; G Genchi
Pyrrolo[1',2':1,2]imidazo[4,5-b]pyridines, pyrrolo- [2',1':2,3]imidazo[4,5-c]pyridines and pyrrolo[2,1-f]purines as potential benzodiazepine ligands.
Farmaco (Società chimica italiana : 1989) 1993;48(9):1261-9.
1993: Angela De Sarro; M Zappalá; Alba Chimirri; Silvana Grasso; G B De Sarro
Quinolones potentiate cefazolin-induced seizures in DBA/2 mice.
Antimicrobial agents and chemotherapy 1993;37(7):1497-503.
1991: Alba Chimirri; Silvana Grasso; Anna Maria Monforte; M Zappala; Angela De Sarro; G B De Sarro
Synthesis and anticonvulsant properties of 3-(1,3,4-thiadiazol-2-yl) thiazolidin-4-ones.
Farmaco (Società chimica italiana : 1989) 1991;46(7-8):935-43.
1991: Alba Chimirri; Silvana Grasso; Anna Maria Monforte; Pietro Monforte; M Zappala
Anti-HIV agents II. Synthesis and in vitro anti-HIV activity of novel 1H,3H-thiazolo[3,4-a]benzimidazoles.
Farmaco (Società chimica italiana : 1989) 1991;46(7-8):925-33.
1991: Alba Chimirri; Silvana Grasso; Anna Maria Monforte; Pietro Monforte; Maria Zappalà
Anti-HIV agents. I: Synthesis and in vitro anti-HIV evaluation of novel 1H,3H-thiazolo[3,4-a]benzimidazoles.
Farmaco (Società chimica italiana : 1989) 1991;46(6):817-23.
1989: Alba Chimirri; Angela De Sarro; Giovambattista De Sarro; Silvana Grasso; Giuseppe Trimarchi; Maria Zappalà
Synthesis and anticonvulsant properties of 2,3,3a,4-tetrahydro-1H-pyrrolo[1,2-a]benzimidazol-1-ones.
Journal of medicinal chemistry 1989;32(1):93-5.
1988: Silvana Grasso; Alba Chimirri; Pietro Monforte; G Fenech; Maria Zappalà; Anna Maria Monforte
Compounds with potential antitumor activity. VI--2-Alkyl-3-[2-(1,3,4-thiadiazolyl)]-4-thiazolidinones.
Il Farmaco; edizione scientifica 1988;43(10):851-6.
1988: Silvana Grasso; Alba Chimirri; Pietro Monforte; G Fenech; Maria Zappalà; Anna Maria Monforte
Compounds with potential antitumor activity--note VIII: 1-alkyl-N,N'-di (1,3,4-thiadiazol-2-yl)methylenediamines.
Bollettino chimico farmaceutico 1988;127(7-8):198-201.
1986: Alba Chimirri; Silvana Grasso; Pietro Monforte; G Fenech; Maria Zappalà
[Compounds with potential antitumor activity. V. 2-Substituted 3-[2-(1,3,4-thiadazolyl)]-4-thiazolidinone].
Il Farmaco; edizione scientifica 1986;41(11):839-51.
1986: Silvana Grasso; Alba Chimirri; Pietro Monforte; G Fenech; Maria Zappalà
[Compounds with potential antitumor activity. IV. Synthesis and antileukemic activity of 1-aryl-N,N'-di-[2-(1,3,4-thiadiazolyl)]methylenediamine].
Il Farmaco; edizione scientifica 1986;41(9):713-21.
1986: Silvana Grasso; A Chimirri; F C Pizzimenti; Maria T Monforte
[Evaluation of the antimicrobial activity of 3-(2-thiazolyl)- and 3-[2-(1,3,4-thiadiazolyl)]-4-thiazolidinones].
Bollettino chimico farmaceutico 1986;125(6):190-2.
1984: Alba Chimirri; Silvana Grasso; G Fenech; Pietro Monforte; C Circosta; F Occhiuto; S Ragusa
1-Halophenyl-N,N'-di-(2-heteroaryl)-methylendiamines and 1-halophenyl-3-(2-heteroaryl)-thiazolidin-4-ones as potential hypotensive agents.
Bollettino chimico farmaceutico 1984;123(9):416-24.
1984: Alba Chimirri; Silvana Grasso; Pietro Monforte; G Fenech
[Compounds with presumable antitumor activity. III. 1-Substituted N,N'-di-2-pyrimidinyl (or pyrazinyl)methylenediamine].
Il Farmaco; edizione scientifica 1984;39(9):797-805.
1984: Silvana Grasso; Alba Chimirri; Pietro Monforte; G Fenech
[Compounds with presumable antitumor activity. II. 2-Substituted 3-(2-thiazolyl) and 3-[2-(1,3,4,-thiadizolyl)]-4-thiazolidinones].
Il Farmaco; edizione scientifica 1984;39(6):505-13.
1981: Pietro Monforte; Silvana Grasso; Alba Chimirri; G Fenech
[2-Substituted thiazole derivatives with possible antitumor activity].
Il Farmaco; edizione scientifica 1981;36(2):109-15.