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Alexei Gratchev

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Tina Fuchs; Alexei Gratchev; Martin Hahn; Alexander W Beham; Claudia Dollt; Alexander Emmert; Julian Fleig; Julia Kzhyshkowska; Michael Neumaier; Ilja Ovsiy; Ioanna Pechlivanidou; Kerstin Puellmann; Wolfgang E Kaminski
A second combinatorial immune receptor in monocytes/macrophages is based on the TCRγδ.
Wolfgang E Kaminski; Julia Kzhyshkowska; Alexander W Beham; Alexei Gratchev; Kerstin Puellmann
On the horizon: flexible immune recognition outside lymphocytes.
Annika Schäfer; Michael P Schön; Steffen Schubert; Anke Schürer; Mladen Tzvetkov; Alexei Gratchev; Christian Hallermann; Lars Hofmann; Petra Laspe; Andreas Ohlenbusch; Jörg Reichrath; Steffen Emmert
Molecular genetic analysis of 16 XP-C patients from Germany: environmental factors predominately contribute to phenotype variations.

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All Publications

2013: Tina Fuchs; Alexei Gratchev; Martin Hahn; Alexander W Beham; Claudia Dollt; Alexander Emmert; Julian Fleig; Julia Kzhyshkowska; Michael Neumaier; Ilja Ovsiy; Ioanna Pechlivanidou; Kerstin Puellmann; Wolfgang E Kaminski
A second combinatorial immune receptor in monocytes/macrophages is based on the TCRγδ.
Immunobiology 2013;218(7):960-8.
2013: Wolfgang E Kaminski; Julia Kzhyshkowska; Alexander W Beham; Alexei Gratchev; Kerstin Puellmann
On the horizon: flexible immune recognition outside lymphocytes.
Immunobiology 2013;218(3):418-26.
2013: Annika Schäfer; Michael P Schön; Steffen Schubert; Anke Schürer; Mladen Tzvetkov; Alexei Gratchev; Christian Hallermann; Lars Hofmann; Petra Laspe; Andreas Ohlenbusch; Jörg Reichrath; Steffen Emmert
Molecular genetic analysis of 16 XP-C patients from Germany: environmental factors predominately contribute to phenotype variations.
Experimental dermatology 2013;22(1):24-9.
2012: Alexei Gratchev; Alexander Orekhov; Igor Sobenin; Julia Kzhyshkowska
Monocytes as a diagnostic marker of cardiovascular diseases.
Immunobiology 2012;217(5):476-82.
2012: Tina Fuchs; Arnold Ganser; Alexei Gratchev; Julia Kzhyshkowska; Michael Neumaier; Ioanna Pechlivanidou; Kerstin Püellmann; Olivia Scharfenstein; Elfi Stobe; Anna Becker; Alexander W Beham; Romy Eichner; Wolfgang E Kaminski
The neutrophil recombinatorial TCR-like immune receptor is expressed across the entire human life span but repertoire diversity declines in old age.
Biochemical and biophysical research communications 2012;419(2):309-15.
2012: Anna Popova; Sergij Goerdt; Julia Kzhyshkowska; Dinara Nurgazieva; Alexei Gratchev
Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2.
Immunobiology 2012;217(3):321-8.
2011: Alexander W Beham; Caroline Breysach; Peter Findeisen; Tina Fuchs; Arnold Ganser; Alexei Gratchev; Heinz Becker; Joseph Keane; Julia Kzhyshkowska; Rebecca Laird; Wiebke Möbius; Michael Neumaier; Septimia Oniga; Teresa Peccerella; Kerstin Puellmann; Dirk Raddatz; Bernadette Saunders; Stefan Schweyer; Roswita Streich; Johannes T Wessels; Wolfgang E Kaminski
A TNF-regulated recombinatorial macrophage immune receptor implicated in granuloma formation in tuberculosis.
PLoS pathogens 2011;7(11):e1002375.
2011: Kai Schledzewski; Cyrill Géraud; Bernd Arnold; Shijun Wang; Hermann-Josef Gröne; Tibor Kempf; Kai C Wollert; Beate K Straub; Peter Schirmacher; Alexandra Demory; Hiltrud Schönhaber; Alexei Gratchev; Lisa Dietz; Hermann-Josef Thierse; Julia Kzhyshkowska; Sergij Goerdt
Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors.
The Journal of clinical investigation 2011;121(2):703-14.
2011: Isabelle Brochériou; Maouche Seraya; Hervé Durand; Vincent Braunersreuther; Gilles Le Naour; Alexei Gratchev; Fabien Koskas; François Mach; Julia Kzhyshkowska; Ewa Ninio
Antagonistic regulation of macrophage phenotype by M-CSF and GM-CSF: implication in atherosclerosis.
Atherosclerosis 2011;214(2):316-24.
2011: Anna Popova; Julia Kzhyshkowska; Dinara Nurgazieva; Sergij Goerdt; Alexei Gratchev
Pro- and anti-inflammatory control of M-CSF-mediated macrophage differentiation.
Immunobiology 2011;216(1-2):164-72.
2009: Jingjing Zhang; Alexei Gratchev; Vladimir Riabov; Srinivas Mamidi; Christina Schmuttermaier; Liis Krusell; Elisabeth Kremmer; Gail Workman; E Helene Sage; Sirpa Jalkanen; Sergij Goerdt; Julia Kzhyshkowska
A novel GGA-binding site is required for intracellular sorting mediated by stabilin-1.
Molecular and cellular biology 2009;29(22):6097-105.
2009: Seung-Yoon Park; Mi-Yeon Jung; Sung-Jin Lee; Kae-Bok Kang; Alexei Gratchev; Vladimir Riabov; Julia Kzhyshkowska; In-San Kim
Stabilin-1 mediates phosphatidylserine-dependent clearance of cell corpses in alternatively activated macrophages.
Journal of cell science 2009;122(Pt 18):3365-73.
2008: Hiroki Inui; Kyu-Seon Oh; Carine Nadem; Takahiro Ueda; Sikandar G Khan; Ahmet Metin; Engin Gozukara; Steffen Emmert; Hanoch Slor; David B Busch; Carl Baker; John J DiGiovanna; Deborah Tamura; Cornelia S Seitz; Alexei Gratchev; Wen Hao Wu; Kee Yang Chung; Hye Jin Chung; Esther Azizi; Roger Woodgate; Thomas D Schneider; Kenneth H Kraemer
Xeroderma pigmentosum-variant patients from America, Europe, and Asia.
The Journal of investigative dermatology 2008;128(8):2055-68.
2008: Alexei Gratchev; Julia Kzhyshkowska; Sheila Kannookadan; Miriam Ochsenreiter; Anna Popova; Xiaolei Yu; Srinivas Mamidi; Eugenia Stonehouse-Usselmann; Isabelle Muller-Molinet; Liming Gooi; Sergij Goerdt
Activation of a TGF-beta-specific multistep gene expression program in mature macrophages requires glucocorticoid-mediated surface expression of TGF-beta receptor II.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(10):6553-65.
2008: Wim J Kleijer; Vincent Laugel; Mark Berneburg; Tiziana Nardo; Heather Fawcett; Alexei Gratchev; Nicolaas G J Jaspers; Alain Sarasin; Miria Stefanini; Alan Lehmann
Incidence of DNA repair deficiency disorders in western Europe: Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy.
DNA repair 2008;7(5):744-50.
2008: Julia Kzhyshkowska; Alexei Gratchev; Christina Schmuttermaier; Heike Brundiers; Liis Krusell; Srinivas Mamidi; Jingjing Zhang; Gail Workman; E Helene Sage; Christine Anderle; Peter Sedlmayr; Sergij Goerdt
Alternatively activated macrophages regulate extracellular levels of the hormone placental lactogen via receptor-mediated uptake and transcytosis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):3028-37.
2008: N Booken; Alexei Gratchev; Jochen Utikal; C Weiss; X Yu; M Qadoumi; M Schmuth; N Sepp; Dorothée Nashan; K Rass; T Tüting; Chalid Assaf; Edgar Dippel; Rudolf Stadler; Claus-Detlev Klemke; Sergij Goerdt
Sézary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3.
Leukemia 2008;22(2):393-9.
2008: Alexei Gratchev
The nucleotide excision repair of DNA in human cells and its association with xeroderma pigmentosum.
Advances in experimental medicine and biology 2008;637():113-9.
2007: Anisa Hana; Dirk Booken; Carmen Henrich; Alexei Gratchev; Nicole Maas-Szabowski; Sergij Goerdt; Hjalmar Kurzen
Functional significance of non-neuronal acetylcholine in skin epithelia.
Life sciences 2007;80(24-25):2214-20.
2007: Julia Kzhyshkowska; Alexei Gratchev; Sergij Goerdt
Human chitinases and chitinase-like proteins as indicators for inflammation and cancer.
Biomarker insights 2007;2():128-46.
2007: Julia Kzhyshkowska; Anna Marciniak-Czochra; Alexei Gratchev
Perspectives of mathematical modelling for understanding of intracellular signalling and vesicular trafficking in macrophages.
Immunobiology 2007;212(9-10):813-25.
2006: Jochen Utikal; Alexei Gratchev; Isabelle Muller-Molinet; Sandra Oerther; Julia Kzhyshkowska; Norbert Arens; Rainer Grobholz; Sheila Kannookadan; Sergij Goerdt
The expression of metastasis suppressor MIM/MTSS1 is regulated by DNA methylation.
International journal of cancer. Journal international du cancer 2006;119(10):2287-93.
2006: Hjalmar Kurzen; Carmen Henrich; Dirk Booken; Nina Poenitz; Alexei Gratchev; Claus-Detlev Klemke; Monika Engstner; Sergij Goerdt; Nicole Maas-Szabowski
Functional characterization of the epidermal cholinergic system in vitro.
The Journal of investigative dermatology 2006;126(11):2458-72.
2006: Jochen Utikal; Georg Haus; Nina Poenitz; Wolfgang Koenen; Walter Back; Edgar Dippel; Alexei Gratchev; Sergij Goerdt
Cutaneous leiomyosarcoma with myxoid alteration arising in a setting of multiple cutaneous smooth muscle neoplasms.
Journal of cutaneous pathology 2006;33 Suppl 2():20-3.
2006: Julia Kzhyshkowska; Alexei Gratchev; Sergij Goerdt
Stabilin-1, a homeostatic scavenger receptor with multiple functions.
Journal of cellular and molecular medicine 2006;10(3):635-49.
2006: Jochen Utikal; Nina Poenitz; Alexei Gratchev; Claus-Detlev Klemke; Dorothea Nashan; Thomas Tüting; Sergij Goerdt
Additional Her 2/neu gene copies in patients with Sézary syndrome.
Leukemia research 2006;30(6):755-60.
2006: Julia Kzhyshkowska; Gail Workman; Marina Cardó-Vila; Wadih Arap; Renata Pasqualini; Alexei Gratchev; Liis Krusell; Sergij Goerdt; E Helene Sage
Novel function of alternatively activated macrophages: stabilin-1-mediated clearance of SPARC.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):5825-32.
2006: Julia Kzhyshkowska; Srinivas Mamidi; Alexei Gratchev; Elisabeth Kremmer; Christina Schmuttermaier; Liis Krusell; Georg Haus; Jochen Utikal; Kai Schledzewski; Joachim Scholtze; Sergij Goerdt
Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway.
Blood 2006;107(8):3221-8.
2006: J-H Martens; Julia Kzhyshkowska; M Falkowski-Hansen; Kai Schledzewski; Alexei Gratchev; U Mansmann; C Schmuttermaier; Edgar Dippel; Wolfgang Koenen; F Riedel; Marko Sankala; Karl Tryggvason; Lester Kobzik; Gerhard Moldenhauer; Bernd Arnold; Sergij Goerdt
Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis.
The Journal of pathology 2006;208(4):574-89.
2006: Alexei Gratchev; Julia Kzhyshkowska; Kirsten Köthe; Isabelle Muller-Molinet; Sheila Kannookadan; Jochen Utikal; Sergij Goerdt
Mphi1 and Mphi2 can be re-polarized by Th2 or Th1 cytokines, respectively, and respond to exogenous danger signals.
Immunobiology 2006;211(6-8):473-86.
2005: Julia Kzhyshkowska; Alexei Gratchev; Heike Brundiers; Srinivas Mamidi; Liis Krusell; Sergij Goerdt
Phosphatidylinositide 3-kinase activity is required for stabilin-1-mediated endosomal transport of acLDL.
Immunobiology 2005;210(2-4):161-73.
2005: Nina Poenitz; J Simon-Ackermann; Alexei Gratchev; M Qadoumi; Claus-Detlev Klemke; Rudolf Stadler; Almut Kremer; M Radenhausen; U Henke; Chalid Assaf; Jochen Utikal; Sergij Goerdt; Edgar Dippel
Overexpression of c-myb in leukaemic and non-leukaemic variants of cutaneous T-cell lymphoma.
Dermatology (Basel, Switzerland) 2005;211(2):84-92.
2005: Alexei Gratchev; Julia Kzhyshkowska; Jochen Utikal; Sergij Goerdt
Interleukin-4 and dexamethasone counterregulate extracellular matrix remodelling and phagocytosis in type-2 macrophages.
Scandinavian journal of immunology 2005;61(1):10-7.
2004: Julia Kzhyshkowska; Alexei Gratchev; Jan-Henning Martens; Olga Pervushina; Srinivas Mamidi; Sophie Johansson; Kai Schledzewski; Berit Hansen; Xiangyuan He; Jordan Tang; Kazuhisa Nakayama; Sergij Goerdt
Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors.
Journal of leukocyte biology 2004;76(6):1151-61.
2004: Hjalmar Kurzen; Hans Berger; Claudia Jäger; Wolfgang Hartschuh; Helmut Näher; Alexei Gratchev; Sergij Goerdt; Martin Deichmann
Phenotypical and molecular profiling of the extraneuronal cholinergic system of the skin.
The Journal of investigative dermatology 2004;123(5):937-49.
2004: Alexei Gratchev; Julia Kzhyshkowska; Karine Duperrier; Jochen Utikal; Florian W Velten; Sergij Goerdt
The receptor for interleukin-17E is induced by Th2 cytokines in antigen-presenting cells.
Scandinavian journal of immunology 2004;60(3):233-7.
2004: Kristijan Cupurdija; Dagmar Azzola; Ursula Hainz; Alexei Gratchev; Andreas Heitger; Osamu Takikawa; Sergij Goerdt; Reinhold Wintersteiger; Gottfried Dohr; Peter Sedlmayr
Macrophages of human first trimester decidua express markers associated to alternative activation.
American journal of reproductive immunology (New York, N.Y. : 1989) 2004;51(2):117-22.
2003: Alexei Gratchev; Pamela Strein; Jochen Utikal; Goerdt Sergij
Molecular genetics of Xeroderma pigmentosum variant.
Experimental dermatology 2003;12(5):529-36.
2003: Jochen Utikal; Claus-Detlev Klemke; Alexei Gratchev; Sergij Goerdt
[Cutaneous non-Langerhans' cell histiocytoses].
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 2003;1(6):471-91; quiz 492-3.
2002: Oliver Politz; Alexei Gratchev; Peter A G McCourt; Kai Schledzewski; Pierre Guillot; Sophie Johansson; Gunbjorg Svineng; Peter Franke; Christoph Kannicht; Julia Kzhyshkowska; Paola Longati; Florian W Velten; Staffan Johansson; Sergij Goerdt
Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues.
The Biochemical journal 2002;362(Pt 1):155-64.
2002: A Siedow; M Szyf; Alexei Gratchev; Ursula Kobalz; Marie-Luise Hanski; Christiane Bumke-Vogt; Hans-Dieter Foss; Ernst-Otto Riecken; Christoph Hanski
De novo expression of the Muc2 gene in pancreas carcinoma cells is triggered by promoter demethylation.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2002;23(1):54-60.
2001: S Hartel-Schenk; Alexei Gratchev; Marie-Luise Hanski; D Ogorek; George Trendelenburg; Michael Hummel; Michael Höpfner; Hans Scherübl; Martin Zeitz; Christoph Hanski
Novel adapter protein AP162 connects a sialyl-Le(x)-positive mucin with an apoptotic signal transduction pathway.
Glycoconjugate journal 2001;18(11-12):915-23.
2001: Alexei Gratchev; Kai Schledzewski; P Guillot; Sergij Goerdt
Alternatively activated antigen-presenting cells: molecular repertoire, immune regulation, and healing.
Skin pharmacology and applied skin physiology 2001;14(5):272-9.
2001: Alexei Gratchev; A Siedow; Christiane Bumke-Vogt; Michael Hummel; Hans-Dieter Foss; Marie-Luise Hanski; Ursula Kobalz; Benno Mann; Hetty Lammert; Ulrich Mansmann; Harald Stein; Ernst-Otto Riecken; Christoph Hanski
Regulation of the intestinal mucin MUC2 gene expression in vivo: evidence for the role of promoter methylation.
Cancer letters 2001;168(1):71-80.
2001: Alexei Gratchev; P Guillot; N Hakiy; Oliver Politz; Constantin E Orfanos; Kai Schledzewski; Sergij Goerdt
Alternatively activated macrophages differentially express fibronectin and its splice variants and the extracellular matrix protein betaIG-H3.
Scandinavian journal of immunology 2001;53(4):386-92.
2001: RW Birk; Alexei Gratchev; N Hakiy; Oliver Politz; Kai Schledzewski; P Guillot; Constantin E Orfanos; Sergij Goerdt
[Alternative activation of antigen-presenting cells: concepts and clinical relevance].
Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete 2001;52(3):193-200.
2000: A Siedow; Alexei Gratchev; Christoph Hanski
Correct evaluation of reporter assays in different cell lines by direct determination of the introduced plasmid amount.
European journal of cell biology 2000;79(2):150-3.
1999: S Backert; Marcos Gelos; Ursula Kobalz; Marie-Luise Hanski; CM Böhm; Benno Mann; N Lövin; Alexei Gratchev; Ulrich Mansmann; Mary Pat Moyer; Ernst-Otto Riecken; Christoph Hanski
Differential gene expression in colon carcinoma cells and tissues detected with a cDNA array.
International journal of cancer. Journal international du cancer 1999;82(6):868-74.
1999: Benno Mann; Alexei Gratchev; CM Böhm; Marie-Luise Hanski; Hans-Dieter Foss; G Demel; B Trojanek; Ingo G H Schmidt-Wolf; Harald Stein; Ernst-Otto Riecken; Heinz J Buhr; Christoph Hanski
FasL is more frequently expressed in liver metastases of colorectal cancer than in matched primary carcinomas.
British journal of cancer 1999;79(7-8):1262-9.
1999: Benno Mann; Marcos Gelos; A Siedow; Marie-Luise Hanski; Alexei Gratchev; M Ilyas; W F Bodmer; Mary Pat Moyer; Ernst-Otto Riecken; Heinz J Buhr; Christoph Hanski
Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1603-8.
1999: Sergij Goerdt; Oliver Politz; Kai Schledzewski; RW Birk; Alexei Gratchev; P Guillot; N Hakiy; Claus-Detlev Klemke; Edgar Dippel; V Kodelja; Constantin E Orfanos
Alternative versus classical activation of macrophages.
Pathobiology : journal of immunopathology, molecular and cellular biology 1999;67(5-6):222-6.
1998: Alexei Gratchev; CM Böhm; E Riede; Hans-Dieter Foss; M Hummel; Benno Mann; S Backert; Heinz J Buhr; Harald Stein; Ernst-Otto Riecken; Christoph Hanski
Regulation of mucin MUC2 gene expression during colon carcinogenesis.
Annals of the New York Academy of Sciences 1998;859():180-3.
1998: CM Böhm; Marie-Luise Hanski; Alexei Gratchev; Benno Mann; Mary Pat Moyer; Ernst-Otto Riecken; Christoph Hanski
A modification of the JAM test is necessary for a correct determination of apoptosis induced by FasL+ adherent tumor cells.
Journal of immunological methods 1998;217(1-2):71-8.
1998: Benno Mann; Alexei Gratchev; E Riede; I Schmidt-Wolf; B Trojanek; P Moyer; Christoph Hanski; Heinz J Buhr
[beta-catenin overexpression in metastasized colorectal carcinoma--an important mechanism in progression of the disease?].
Langenbecks Archiv für Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress 1998;115(Suppl I):303-6.
1998: E Riede; Alexei Gratchev; Hans-Dieter Foss; Benno Mann; Heinz J Buhr; Christoph Hanski
[Increased methylation of promotor region suppresses expression of MUC2 gene in colon carcinoma cells].
Langenbecks Archiv für Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress 1998;115(Suppl I):299-302.
1997: Christoph Hanski; E Riede; Alexei Gratchev; Hans-Dieter Foss; CM Böhm; E Klussmann; M Hummel; Benno Mann; Heinz J Buhr; Harald Stein; Y S Kim; J Gum; Ernst-Otto Riecken
MUC2 gene suppression in human colorectal carcinomas and their metastases: in vitro evidence of the modulatory role of DNA methylation.
Laboratory investigation; a journal of technical methods and pathology 1997;77(6):685-95.