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Douglas Green

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Tudor Moldoveanu; Amanda Nourse; Richard W Kriwacki; Fabien Llambi; Patrick Fitzgerald; Kalle Gehring; Christy R Grace; Douglas R Green
BID-induced structural changes in BAK promote apoptosis.
Christopher Lupfer; Jennifer Martinez; Sandra Milasta; Paul Thomas; Peter Vogel; Ramnik J Xavier; Mondira Kundu; Mohamed Lamkanfi; Paras K Anand; Hongbo Chi; Charles A Dinarello; Peter C Doherty; Douglas R Green; Maggie Green; Gonghua Huang; Thirumala-Devi Kanneganti
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.
Ariele Viacava Follis; Christy R Grace; Douglas R Green; Lie Min; Amanda Nourse; Li Ou; Stephen W White; Mi-Kyung Yun; Katherine Baran; Jerry E Chipuk; John C Fisher; Richard W Kriwacki
PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.

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All Publications

2013: Tudor Moldoveanu; Amanda Nourse; Richard W Kriwacki; Fabien Llambi; Patrick Fitzgerald; Kalle Gehring; Christy R Grace; Douglas R Green
BID-induced structural changes in BAK promote apoptosis.
Nature structural & molecular biology 2013;20(5):589-97.
2013: Christopher Lupfer; Jennifer Martinez; Sandra Milasta; Paul Thomas; Peter Vogel; Ramnik J Xavier; Mondira Kundu; Mohamed Lamkanfi; Paras K Anand; Hongbo Chi; Charles A Dinarello; Peter C Doherty; Douglas R Green; Maggie Green; Gonghua Huang; Thirumala-Devi Kanneganti
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.
Nature immunology 2013;14(5):480-8.
2013: Ariele Viacava Follis; Christy R Grace; Douglas R Green; Lie Min; Amanda Nourse; Li Ou; Stephen W White; Mi-Kyung Yun; Katherine Baran; Jerry E Chipuk; John C Fisher; Richard W Kriwacki
PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.
Nature chemical biology 2013;9(3):163-8.
2013: Douglas R Green; Henning Walczak
Apoptosis therapy: driving cancers down the road to ruin.
Nature medicine 2013;19(2):131-3.
2013: Andreas U Lindner; Fabien Llambi; Deborah A McNamara; Frank Murray; Deborah Ryan; Karen Boland; Gerhardt J Boukes; Mary D Cannon; Caoimhín G Concannon; Douglas R Green; Suzanne Hector; Heinrich J Huber; Elaine W Kay; Joan Kehoe; Jochen H M Prehn
Systems analysis of BCL2 protein family interactions establishes a model to predict responses to chemotherapy.
Cancer research 2013;73(2):519-28.
2012: Lukas Bossaller; Ping-I Chiang; Katherine A Fitzgerald; Sandhya Ganesan; Douglas R Green; William J Kaiser; Ann Marshak-Rothstein; Edward Mocarski; Vijay A K Rathinam; Christian Schmidt-Lauber; Neal Silverman; Deepa Subramanian; Eicke Latz
Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(12):5508-12.
2012: Douglas R Green
Metabolism and immunity: the old and the new.
Seminars in immunology 2012;24(6):383.
2012: Katherine C Verbist; Ruoning Wang; Douglas R Green
T cell metabolism and the immune response.
Seminars in immunology 2012;24(6):399-404.
2012: Douglas R Green; Bernadette Victor
The pantheon of the fallen: why are there so many forms of cell death?
Trends in cell biology 2012;22(11):555-6.
2012: Ruoning Wang; Douglas R Green
Metabolic checkpoints in activated T cells.
Nature immunology 2012;13(10):907-15.
2012: Ruoning Wang; Douglas R Green
Metabolic reprogramming and metabolic dependency in T cells.
Immunological reviews 2012;249(1):14-26.
2012: Rhonda M Perciavalle; John D Schuetz; Daniel P Stewart; Jamshid Temirov; Richard J Youle; Madhavi Bathina; Megan M Cleland; Douglas R Green; Brian Koss; John Lynch; Sandra Milasta; Stéphane Pelletier; Joseph T Opferman
Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.
Nature cell biology 2012;14(6):575-83.
2012: S P Garrison; Douglas R Green; J R Jeffers; Joseph T Opferman; M J Parsons; D C Phillips; J E Rehg; Jerry E Chipuk; Gerard P Zambetti
Genetically defining the mechanism of Puma- and Bim-induced apoptosis.
Cell death and differentiation 2012;19(4):642-9.
2012: Cheryl E Bender; Patrick Fitzgerald; Fabien Llambi; Gavin P McStay; Jason Pellettieri; Guy S Salvesen; Alejandro Sanchez; Stephen W G Tait; Douglas O Tupper; Douglas R Green
Mitochondrial pathway of apoptosis is ancestral in metazoans.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(13):4904-9.
2012: Yasmine A Valentin-Vega; John L Cleveland; Frank C Dorsey; Douglas R Green; Kirsteen H Maclean; Sandra Milasta; Meredith Steeves; Jacqueline Tait-Mulder; Michael B Kastan
Mitochondrial dysfunction in ataxia-telangiectasia.
Blood 2012;119(6):1490-500.
2012: Monika C Wolkers; Ton N Schumacher; Ramon Arens; Patrick Fitzgerald; Carmen Gerlach; Douglas R Green; edith janssen; Jan Paul Medema; Stephen P Schoenberger
Nab2 regulates secondary CD8+ T-cell responses through control of TRAIL expression.
Blood 2012;119(3):798-804.
2012: Ruoning Wang; Douglas R Green
The immune diet: meeting the metabolic demands of lymphocyte activation.
F1000 biology reports 2012;4():9.
2011: Fabien Llambi; Laura L McCormick; Tudor Moldoveanu; Stephen W G Tait; Jamshid Temirov; Lisa Bouchier-Hayes; Christopher P Dillon; Douglas R Green
A unified model of mammalian BCL-2 protein family interactions at the mitochondria.
Molecular cell 2011;44(4):517-31.
2011: Md Hasan Zaki; Mohamed Lamkanfi; R K Subbarao Malireddi; Peter Vogel; Paras Anand; John Bertin; Mathilde Body-Malapel; Douglas R Green; Thirumala-Devi Kanneganti
The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis.
Cancer cell 2011;20(5):649-60.
2011: Douglas R Green; Bennett Van Houten
SnapShot: Mitochondrial quality control.
Cell 2011;147(4):950, 950.e1.
2011: Douglas R Green
Immunology: A heavyweight knocked out.
Nature 2011;479(7371):48-50.
2011: Andrew Oberst; Douglas R Green
It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival.
Nature reviews. Molecular cell biology 2011;12(11):757-63.
2011: Ricardo Weinlich; Christopher P Dillon; Douglas R Green
Ripped to death.
Trends in cell biology 2011;21(11):630-7.
2011: Andrea L Szymczak-Workman; Greg M Delgoffe; Douglas R Green; Dario A A Vignali
Cutting edge: regulatory T cells do not mediate suppression via programmed cell death pathways.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(9):4416-20.
2011: Douglas R Green
The end and after: how dying cells impact the living organism.
Immunity 2011;35(4):441-4.
2011: Jennifer Martinez; Rachel Ness; Andrew Oberst; Michael O Hengartner; Johann Almendinger; Christopher P Dillon; Patrick Fitzgerald; Douglas R Green
Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(42):17396-401.
2011: Douglas R Green; Andrew Oberst; Christopher P Dillon; Ricardo Weinlich; Guy S Salvesen
RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts.
Molecular cell 2011;44(1):9-16.
2011: Sirish K Ippagunta; Yoshinori Fukui; Douglas R Green; Mohamed Lamkanfi; R K Subbarao Malireddi; Geoffrey A Neale; Patrick J Shaw; Lieselotte Vande Walle; Thirumala-Devi Kanneganti
The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization.
Nature immunology 2011;12(10):1010-6.
2011: Monika C Wolkers; Stephen P Schoenberger; Steven J Bensinger; Douglas R Green; edith janssen
Interleukin-2 rescues helpless effector CD8+ T cells by diminishing the susceptibility to TRAIL mediated death.
Immunology letters 2011;139(1-2):25-32.
2011: Kai Yang; Douglas R Green; Weifeng He; Geoffrey Neale; Hongbo Chi
The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function.
Nature immunology 2011;12(9):888-97.
2011: Douglas R Green; Lorenzo Galluzzi; Guido Kroemer
Mitochondria and the autophagy-inflammation-cell death axis in organismal aging.
Science (New York, N.Y.) 2011;333(6046):1109-12.
2011: Lewis Z Shi; Peter Vogel; Ruoning Wang; Douglas R Green; Gonghua Huang; Geoffrey Neale; Hongbo Chi
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells.
The Journal of experimental medicine 2011;208(7):1367-76.
2011: Melissa J Parsons; Douglas R Green
Death receptors and mitochondria: life depends on the liver.
Hepatology (Baltimore, Md.) 2011;54(1):13-5.
2011: Thomas R Gawriluk; Amber N Hale; Jodi A Flaws; Christopher P Dillon; Douglas R Green; Edmund B Rucker
Autophagy is a cell survival program for female germ cells in the murine ovary.
Reproduction (Cambridge, England) 2011;141(6):759-65.
2011: Thomas A Ferguson; Jayoung Choi; Douglas R Green
Armed response: how dying cells influence T-cell functions.
Immunological reviews 2011;241(1):77-88.
2011: Andrew Oberst; Christopher P Dillon; Ricardo Weinlich; Laura L McCormick; Patrick Fitzgerald; Cristina Pop; Razq Hakem; Guy S Salvesen; Douglas R Green
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.
Nature 2011;471(7338):363-7.
2011: Douglas R Green
'Tit-for-tat' in cell biology.
Nature reviews. Molecular cell biology 2011;12(2):73.
2011: Fabien Llambi; Douglas R Green
Apoptosis and oncogenesis: give and take in the BCL-2 family.
Current opinion in genetics & development 2011;21(1):12-20.
2010: Stephen W G Tait; Douglas R Green
Cell survival in tough times: The mitochondrial recovery plan.
Cell cycle (Georgetown, Tex.) 2010;9(21):4254-5.
2010: Douglas R Green
Stress in biomedical research: six impossible things.
Molecular cell 2010;40(2):176-8.
2010: Valere Busuttil; Nathalie Droin; Laura McCormick; Francesca Bernassola; Eleonora Candi; Gerry Melino; Douglas R Green
NF-kappaB inhibits T-cell activation-induced, p73-dependent cell death by induction of MDM2.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(42):18061-6.
2010: Douglas R Green; Ruoning Wang
Calcium and energy: making the cake and eating it too?
Cell 2010;142(2):200-2.
2010: Andrew Oberst; Cristina Pop; Alexandre G Tremblay; Véronique Blais; Jean-Bernard Denault; Guy S Salvesen; Douglas R Green
Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation.
The Journal of biological chemistry 2010;285(22):16632-42.
2010: Douglas R Green
Cancer: A wolf in wolf's clothing.
Nature 2010;465(7297):433.
2010: Stephen W G Tait; Melissa J Parsons; Fabien Llambi; Lisa Bouchier-Hayes; Samuel Connell; Cristina Muñoz-Pinedo; Douglas R Green
Resistance to caspase-independent cell death requires persistence of intact mitochondria.
Developmental cell 2010;18(5):802-13.
2010: Douglas R Green
Cell competition: pirates on the tangled bank.
Cell stem cell 2010;6(4):287-8.
2010: Joseph T Opferman; Douglas R Green
DUB-le Trouble for Cell Survival.
Cancer cell 2010;17(2):117-9.
2010: Jerry E Chipuk; Tudor Moldoveanu; Fabien Llambi; Melissa J Parsons; Douglas R Green
The BCL-2 family reunion.
Molecular cell 2010;37(3):299-310.
2010: Julie L McAuley; Jerry E Chipuk; Kelli L Boyd; Nick Van De Velde; Douglas R Green; Jonathan A McCullers
PB1-F2 proteins from H5N1 and 20 century pandemic influenza viruses cause immunopathology.
PLoS pathogens 2010;6(7):e1001014.
2010: Melissa J Parsons; Douglas R Green
Mitochondria in cell death.
Essays in biochemistry 2010;47():99-114.
2009: Anna Colell; Douglas R Green; Jean-Ehrland Ricci
Novel roles for GAPDH in cell death and carcinogenesis.
Cell death and differentiation 2009;16(12):1573-81.
2009: Lisa Bouchier-Hayes; Andrew Oberst; Gavin P McStay; Samuel Connell; Stephen W G Tait; Christopher P Dillon; Jonathan M Flanagan; Helen M Beere; Douglas R Green
Characterization of cytoplasmic caspase-2 activation by induced proximity.
Molecular cell 2009;35(6):830-40.
2009: Jerry E Chipuk; Douglas R Green
PUMA cooperates with direct activator proteins to promote mitochondrial outer membrane permeabilization and apoptosis.
Cell cycle (Georgetown, Tex.) 2009;8(17):2692-6.
2009: Douglas R Green; Thomas Ferguson; Laurence Zitvogel; Guido Kroemer
Immunogenic and tolerogenic cell death.
Nature reviews. Immunology 2009;9(5):353-63.
2009: Douglas R Green; Guido Kroemer
Cytoplasmic functions of the tumour suppressor p53.
Nature 2009;458(7242):1127-30.
2009: Mohamed Lamkanfi; Lilian O Moreira; Patrudu Makena; Diana C J Spierings; Kelli Boyd; Peter J Murray; Douglas R Green; Thirumala-Devi Kanneganti
Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival.
Blood 2009;113(12):2742-5.
2009: Luiz C Godoy; Cristina Muñoz-Pinedo; Laura Castro; Simone Cardaci; Christopher M Schonhoff; Michael King; Verónica Tórtora; Mónica Marín; Qian Miao; Jian Fei Jiang; Alexandr Kapralov; Ronald Jemmerson; Gary G Silkstone; Jinal N Patel; James E Evans; Michael T Wilson; Douglas R Green; Valerian E Kagan; Rafael Radi; Joan B Mannick
Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2653-8.
2009: Melissa J Parsons; Douglas R Green
Mitochondria and apoptosis: a quick take on a long view.
F1000 biology reports 2009;1():17.
2009: Stephen W G Tait; Lisa Bouchier-Hayes; Andrew Oberst; Samuel Connell; Douglas R Green
Live to dead cell imaging.
Methods in molecular biology (Clifton, N.J.) 2009;559():33-48.
2009: Miguel A Sanjuan; Sandra Milasta; Douglas R Green
Toll-like receptor signaling in the lysosomal pathways.
Immunological reviews 2009;227(1):203-20.
2008: Tudor Moldoveanu; Kalle Gehring; Douglas R Green
Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains.
Nature 2008;456(7220):404-8.
2008: Stephen W G Tait; Douglas R Green
Caspase-independent cell death: leaving the set without the final cut.
Oncogene 2008;27(50):6452-61.
2008: Douglas R Green; Jerry E Chipuk
Apoptosis: Stabbed in the BAX.
Nature 2008;455(7216):1047-9.
2008: Hirotaka Kazama; Jean-Ehrland Ricci; John M Herndon; George Hoppe; Douglas R Green; Thomas A Ferguson
Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein.
Immunity 2008;29(1):21-32.
2008: Miguel A Sanjuan; Douglas R Green
Eating for good health: linking autophagy and phagocytosis in host defense.
Autophagy 2008;4(5):607-11.
2008: A Oberst; C Bender; Douglas R Green
Living with death: the evolution of the mitochondrial pathway of apoptosis in animals.
Cell death and differentiation 2008;15(7):1139-46.
2008: Jerry E Chipuk; Douglas R Green
How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
Trends in cell biology 2008;18(4):157-64.
2008: Lisa Bouchier-Hayes; Cristina Muñoz-Pinedo; Samuel Connell; Douglas R Green
Measuring apoptosis at the single cell level.
Methods (San Diego, Calif.) 2008;44(3):222-8.
2008: Douglas R Green; Peter J McKinnon
A survivor hits the breaks.
Molecular cell 2008;29(4):411-2.
2008: Douglas R Green
Fas Bim boom!
Immunity 2008;28(2):141-3.
2008: Ann Cassidy-Stone; Jerry E Chipuk; Elena Ingerman; Cheng Song; Choong Yoo; Tomomi Kuwana; Mark J Kurth; Jared T Shaw; Jenny E Hinshaw; Douglas R Green; Jodi Nunnari
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization.
Developmental cell 2008;14(2):193-204.
2008: G P McStay; G S Salvesen; Douglas R Green
Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways.
Cell death and differentiation 2008;15(2):322-31.
2007: Miguel A Sanjuan; Christopher P Dillon; Stephen W G Tait; Simon Moshiach; Frank C Dorsey; Samuel Connell; Masaaki Komatsu; Keiji Tanaka; John L Cleveland; Sebo Withoff; Douglas R Green
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis.
Nature 2007;450(7173):1253-7.
2007: Douglas R Green
Life, death, BH3 profiles, and the salmon mousse.
Cancer cell 2007;12(2):97-9.
2007: Anna Colell; Jean-Ehrland Ricci; Stephen Tait; Sandra Milasta; Ulrich Maurer; Lisa Bouchier-Hayes; Patrick Fitzgerald; Ana Guio-Carrion; Nigel Waterhouse; Cindy Wei Li; Bernard Mari; Pascal Barbry; Donald D Newmeyer; Helen M Beere; Douglas R Green
GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation.
Cell 2007;129(5):983-97.
2007: Cristina Pop; Patrick Fitzgerald; Douglas R Green; Guy S Salvesen
Role of proteolysis in caspase-8 activation and stabilization.
Biochemistry 2007;46(14):4398-407.
2006: Cristina Muñoz-Pinedo; Ana Guío-Carrión; Joshua C Goldstein; Patrick Fitzgerald; Donald D Newmeyer; Douglas R Green
Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(31):11573-8.
2006: Jerry E Chipuk; Lisa Bouchier-Hayes; Douglas R Green
Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario.
Cell death and differentiation 2006;13(8):1396-402.
2006: Douglas R Green; Jerry E Chipuk
p53 and metabolism: Inside the TIGAR.
Cell 2006;126(1):30-2.
2006: Diana C J Spierings; Edward E Lemmens; Kirpal Grewal; Stephen P Schoenberger; Douglas R Green
Duration of CTL activation regulates IL-2 production required for autonomous clonal expansion.
European journal of immunology 2006;36(7):1707-17.
2006: Douglas R Green
At the gates of death.
Cancer cell 2006;9(5):328-30.
2006: Christine Bonzon; Lisa Bouchier-Hayes; Lisa J Pagliari; Douglas R Green; Donald D Newmeyer
Caspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death.
Molecular biology of the cell 2006;17(5):2150-7.
2006: S Kiessling; Douglas R Green
Cell survival and proliferation in Drosophila S2 cells following apoptotic stress in the absence of the APAF-1 homolog, ARK, or downstream caspases.
Apoptosis : an international journal on programmed cell death 2006;11(4):497-507.
2006: Ulrich Maurer; Céline Charvet; Allan S Wagman; Emmanuel Dejardin; Douglas R Green
Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1.
Molecular cell 2006;21(6):749-60.
2006: Shine Tu; Gavin P McStay; Lorrie Boucher; Tak Mak; Helen M Beere; Douglas R Green
In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis.
Nature cell biology 2006;8(1):72-7.
2005: Lisa J Pagliari; Tomomi Kuwana; Christine Bonzon; Donald D Newmeyer; Shine Tu; Helen M Beere; Douglas R Green
The multidomain proapoptotic molecules Bax and Bak are directly activated by heat.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(50):17975-80.
2005: Diana Spierings; Gavin McStay; Maya Saleh; Cheryl Bender; Jerry E Chipuk; Uli Maurer; Douglas R Green
Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis.
Science (New York, N.Y.) 2005;310(5745):66-7.
2005: Douglas R Green; Guido Kroemer
Pharmacological manipulation of cell death: clinical applications in sight?
The Journal of clinical investigation 2005;115(10):2610-7.
2005: Jerry E Chipuk; Lisa Bouchier-Hayes; Tomomi Kuwana; Donald D Newmeyer; Douglas R Green
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53.
Science (New York, N.Y.) 2005;309(5741):1732-5.
2005: Douglas R Green
Apoptotic pathways: ten minutes to dead.
Cell 2005;121(5):671-4.
2005: Maya Saleh; Lisa J Pagliari; Douglas R Green
Life support: the alpha4 phosphatase subunit in cell survival and apoptosis.
Trends in cell biology 2005;15(6):285-7.
2005: Egle Simelyte; Sanna Rosengren; David L Boyle; Maripat Corr; Douglas R Green; Gary S Firestein
Regulation of arthritis by p53: critical role of adaptive immunity.
Arthritis and rheumatism 2005;52(6):1876-84.
2005: Cristina Muñoz-Pinedo; Douglas R Green; Albert van den Berg
Confocal restricted-height imaging of suspension cells (CRISC) in a PDMS microdevice during apoptosis.
Lab on a chip 2005;5(6):628-33.
2005: Joshua C Goldstein; Cristina Muñoz-Pinedo; Jean-Ehrland Ricci; S R Adams; A Kelekar; Martin Schuler; Roger Y Tsien; Douglas R Green
Cytochrome c is released in a single step during apoptosis.
Cell death and differentiation 2005;12(5):453-62.
2005: edith janssen; Nathalie M Droin; Edward E Lemmens; Michael J Pinkoski; Steven J Bensinger; Benjamin D Ehst; Thomas Griffith; Douglas R Green; Stephen P Schoenberger
CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death.
Nature 2005;434(7029):88-93.
2005: Michael J Pinkoski; Douglas R Green
Apoptosis in the regulation of immune responses.
The Journal of rheumatology. Supplement 2005;74():19-25.
2005: Jerry E Chipuk; Douglas R Green
Do inducers of apoptosis trigger caspase-independent cell death?
Nature reviews. Molecular cell biology 2005;6(3):268-75.
2005: Tomomi Kuwana; Lisa Bouchier-Hayes; Jerry E Chipuk; Christine Bonzon; Barbara A Sullivan; Douglas R Green; Donald D Newmeyer
BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly.
Molecular cell 2005;17(4):525-35.
2005: Shinichiro Yada; Noriaki Takamura; Kyoko Inagaki-Ohara; Melissa K O'leary; Christoph Wasem; Thomas Brunner; Douglas R Green; Tesu Lin; Michael J Pinkoski
The role of p53 and Fas in a model of acute murine graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1291-7.
2004: Ralph Torgler; Stephan M Jakob; Edgar C Ontsouka; Ulrich Nachbur; Christoph Mueller; Douglas R Green; Thomas Brunner
Regulation of activation-induced Fas (CD95/Apo-1) ligand expression in T cells by the cyclin B1/Cdk1 complex.
The Journal of biological chemistry 2004;279(36):37334-42.
2004: Douglas R Green; Guido Kroemer
The pathophysiology of mitochondrial cell death.
Science (New York, N.Y.) 2004;305(5684):626-9.
2004: Jean-Ehrland Ricci; Cristina Muñoz-Pinedo; Patrick Fitzgerald; Beatrice Bailly-Maitre; Guy Perkins; Nagendra Yadava; Immo E Scheffler; Mark H Ellisman; Douglas R Green
Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain.
Cell 2004;117(6):773-86.
2004: Jerry E Chipuk; Douglas R Green
Cytoplasmic p53: bax and forward.
Cell cycle (Georgetown, Tex.) 2004;3(4):429-31.
2004: Nathalie M Droin; Douglas R Green
Role of Bcl-2 family members in immunity and disease.
Biochimica et biophysica acta 2004;1644(2-3):179-88.
2004: Jerry E Chipuk; Tomomi Kuwana; Lisa Bouchier-Hayes; Nathalie M Droin; Donald D Newmeyer; Martin Schuler; Douglas R Green
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
Science (New York, N.Y.) 2004;303(5660):1010-4.
2003: Jerry E Chipuk; Ulrich Maurer; Douglas R Green; Martin Schuler
Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription.
Cancer cell 2003;4(5):371-81.
2003: Nathalie M Droin; Michael J Pinkoski; Emmanuel Dejardin; Douglas R Green
Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses.
Molecular and cellular biology 2003;23(21):7638-47.
2003: Jerry E Chipuk; Douglas R Green
p53's believe it or not: lessons on transcription-independent death.
Journal of clinical immunology 2003;23(5):355-61.
2003: Douglas R Green; Nathalie M Droin; Michael Pinkoski
Activation-induced cell death in T cells.
Immunological reviews 2003;193():70-81.
2003: Douglas R Green
Overview: apoptotic signaling pathways in the immune system.
Immunological reviews 2003;193():5-9.
2003: Martin Schuler; U Maurer; Joshua C Goldstein; F Breitenbücher; Sandra Hoffarth; Nigel Waterhouse; Douglas R Green
p53 triggers apoptosis in oncogene-expressing fibroblasts by the induction of Noxa and mitochondrial Bax translocation.
Cell death and differentiation 2003;10(4):451-60.
2003: Marianne J B van Stipdonk; Gijs Hardenberg; Martijn Bijker; Edward E Lemmens; Nathalie M Droin; Douglas R Green; Stephen P Schoenberger
Dynamic programming of CD8+ T lymphocyte responses.
Nature immunology 2003;4(4):361-5.
2003: Douglas R Green
Death and NF-kappaB in T cell activation: life at the edge.
Molecular cell 2003;11(3):551-2.
2003: Jean-Ehrland Ricci; Roberta Anne Gottlieb; Douglas R Green
Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis.
The Journal of cell biology 2003;160(1):65-75.
2002: Michael J Pinkoski; Nathalie M Droin; Tesu Lin; Laurent Genestier; Thomas A Ferguson; Douglas R Green
Nonlymphoid Fas ligand in peptide-induced peripheral lymphocyte deletion.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(25):16174-9.
2002: Tomomi Kuwana; Mason R Mackey; Guy Perkins; Mark H Ellisman; Martin Latterich; Roger Schneiter; Douglas R Green; Donald D Newmeyer
Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane.
Cell 2002;111(3):331-42.
2002: Michael J Pinkoski; Nathalie M Droin; Douglas R Green
Tumor necrosis factor alpha up-regulates non-lymphoid Fas-ligand following superantigen-induced peripheral lymphocyte activation.
The Journal of biological chemistry 2002;277(44):42380-5.
2002: Emmanuel Dejardin; Nathalie M Droin; Mireille Delhase; Elvira Haas; Yixue Cao; Constantin Makris; Zhi-Wei Li; Michael Karin; Carl Ware; Douglas R Green
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways.
Immunity 2002;17(4):525-35.
2002: Douglas W Ethell; Ross Kinloch; Douglas R Green
Metalloproteinase shedding of Fas ligand regulates beta-amyloid neurotoxicity.
Current biology : CB 2002;12(18):1595-600.
2002: Yuji Yamanishi; David L Boyle; Sanna Rosengren; Douglas R Green; Nathan J Zvaifler; Gary S Firestein
Regional analysis of p53 mutations in rheumatoid arthritis synovium.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):10025-30.
2002: Katja C Zimmermann; Jean-Ehrland Ricci; Nathalie M Droin; Douglas R Green
The role of ARK in stress-induced apoptosis in Drosophila cells.
The Journal of cell biology 2002;156(6):1077-87.
2002: Douglas R Green; Gerard I Evan
A matter of life and death.
Cancer cell 2002;1(1):19-30.
2002: Nigel Waterhouse; Jean-Ehrland Ricci; Douglas R Green
And all of a sudden it's over: mitochondrial outer-membrane permeabilization in apoptosis.
Biochimie 2002;84(2-3):113-21.
2002: John C Reed; Douglas R Green
Remodeling for demolition: changes in mitochondrial ultrastructure during apoptosis.
Molecular cell 2002;9(1):1-3.
2002: Yuji Yamanishi; David L Boyle; Michael J Pinkoski; Artin Mahboubi; Tesu Lin; Zuoning Han; Nathan J Zvaifler; Douglas R Green; Gary S Firestein
Regulation of joint destruction and inflammation by p53 in collagen-induced arthritis.
The American journal of pathology 2002;160(1):123-30.
2002: Michael J Pinkoski; Douglas R Green
Lymphocyte apoptosis: refining the paths to perdition.
Current opinion in hematology 2002;9(1):43-9.
2001: Douglas R Green; T A Ferguson
The role of Fas ligand in immune privilege.
Nature reviews. Molecular cell biology 2001;2(12):917-24.
2001: K C Zimmermann; Christine Bonzon; Douglas R Green
The machinery of programmed cell death.
Pharmacology & therapeutics 2001;92(1):57-70.
2001: K C Zimmermann; Douglas R Green
How cells die: apoptosis pathways.
The Journal of allergy and clinical immunology 2001;108(4 Suppl):S99-103.
2001: BB Wolf; Martin Schuler; W Li; B Eggers-Sedlet; W Lee; Pankaj Tailor; P Fitzgerald; G B Mills; Douglas R Green
Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity.
The Journal of biological chemistry 2001;276(36):34244-51.
2001: Christoph Wasem; Corina Frutschi; Diana Arnold; Claudio Vallan; Tesu Lin; Douglas R Green; Christoph Mueller; Thomas Brunner
Accumulation and activation-induced release of preformed Fas (CD95) ligand during the pathogenesis of experimental graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2936-41.
2001: Nigel Waterhouse; Joshua C Goldstein; O von Ahsen; Martin Schuler; Donald D Newmeyer; Douglas R Green
Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process.
The Journal of cell biology 2001;153(2):319-28.
2001: Michael J Pinkoski; Nigel Waterhouse; JA Heibein; BB Wolf; Tomomi Kuwana; Joshua C Goldstein; Donald D Newmeyer; R Chris Bleackley; Douglas R Green
Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway.
The Journal of biological chemistry 2001;276(15):12060-7.
2001: Kyoko Inagaki-Ohara; Shinichiro Yada; Noriaki Takamura; M Reaves; X Yu; E Liu; IA Rooney; S Nicholas; A Castro; Carl Ware; Douglas R Green; Tesu Lin
p53-dependent radiation-induced crypt intestinal epithelial cells apoptosis is mediated in part through TNF-TNFR1 system.
Oncogene 2001;20(7):812-8.
2001: Nigel Waterhouse; Joshua C Goldstein; Ruth M Kluck; Donald D Newmeyer; Douglas R Green
The (Holey) study of mitochondria in apoptosis.
Methods in cell biology 2001;66():365-91.
2001: Helen M Beere; Douglas R Green
Stress management - heat shock protein-70 and the regulation of apoptosis.
Trends in cell biology 2001;11(1):6-10.
2000: O von Ahsen; Nigel Waterhouse; Tomomi Kuwana; Donald D Newmeyer; Douglas R Green
The 'harmless' release of cytochrome c.
Cell death and differentiation 2000;7(12):1192-9.
2000: JA Heibein; Ing Swie Goping; Michele Barry; Michael J Pinkoski; Gordon C Shore; Douglas R Green; R Chris Bleackley
Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax.
The Journal of experimental medicine 2000;192(10):1391-402.
2000: K C Zimmermann; Nigel Waterhouse; Joshua C Goldstein; Martin Schuler; Douglas R Green
Aspirin induces apoptosis through release of cytochrome c from mitochondria.
Neoplasia (New York, N.Y.) 2000;2(6):505-13.
2000: S Kasibhatla; H M Beere; Thomas Brunner; F Echeverri; Douglas R Green
A 'non-canonical' DNA-binding element mediates the response of the Fas-ligand promoter to c-Myc.
Current biology : CB 2000;10(19):1205-8.
2000: Kimitoshi Nakamura; Ella Bossy-Wetzel; K Burns; Marc P Fadel; M Lozyk; Ing Swie Goping; Michal Opas; R Chris Bleackley; Douglas R Green; Marek Michalak
Changes in endoplasmic reticulum luminal environment affect cell sensitivity to apoptosis.
The Journal of cell biology 2000;150(4):731-40.
2000: Helen M Beere; BB Wolf; K Cain; D D Mosser; A Mahboubi; Tomomi Kuwana; Pankaj Tailor; R I Morimoto; Gerald M Cohen; Douglas R Green
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome.
Nature cell biology 2000;2(8):469-75.
2000: Douglas R Green
Apoptosis and sphingomyelin hydrolysis. The flip side.
The Journal of cell biology 2000;150(1):F5-7.
2000: Douglas R Green
Apoptotic pathways: paper wraps stone blunts scissors.
Cell 2000;102(1):1-4.
2000: Michele Barry; JA Heibein; Michael J Pinkoski; S F Lee; Richard W Moyer; Douglas R Green; R Chris Bleackley
Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.
Molecular and cellular biology 2000;20(11):3781-94.
2000: Donald D Newmeyer; Ella Bossy-Wetzel; Ruth M Kluck; BB Wolf; Helen M Beere; Douglas R Green
Bcl-xL does not inhibit the function of Apaf-1.
Cell death and differentiation 2000;7(4):402-7.
2000: Thomas Brunner; S Kasibhatla; Michael J Pinkoski; Corina Frutschi; N J Yoo; F Echeverri; Artin Mahboubi; Douglas R Green
Expression of Fas ligand in activated T cells is regulated by c-Myc.
The Journal of biological chemistry 2000;275(13):9767-72.
2000: Martin Schuler; Ella Bossy-Wetzel; Joshua C Goldstein; Patrick Fitzgerald; Douglas R Green
p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release.
The Journal of biological chemistry 2000;275(10):7337-42.
2000: Joshua C Goldstein; Nigel Waterhouse; P Juin; G I Evan; Douglas R Green
The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant.
Nature cell biology 2000;2(3):156-62.
2000: Joshua C Goldstein; Ruth M Kluck; Douglas R Green
A single cell analysis of apoptosis. Ordering the apoptotic phenotype.
Annals of the New York Academy of Sciences 2000;926():132-41.
2000: Ella Bossy-Wetzel; Douglas R Green
Assays for cytochrome c release from mitochondria during apoptosis.
Methods in enzymology 2000;322():235-42.
2000: Ella Bossy-Wetzel; Douglas R Green
Detection of apoptosis by annexin V labeling.
Methods in enzymology 2000;322():15-8.
1999: Michael J Pinkoski; Douglas R Green
Fas ligand, death gene.
Cell death and differentiation 1999;6(12):1174-81.
1999: M Villalba; S Kasibhatla; Laurent Genestier; Artin Mahboubi; Douglas R Green; A Altman
Protein kinase ctheta cooperates with calcineurin to induce Fas ligand expression during activation-induced T cell death.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(11):5813-9.
1999: Ruth M Kluck; Mauro Degli Esposti; Guy Perkins; Christian Renken; Tomomi Kuwana; Ella Bossy-Wetzel; M Goldberg; T Allen; M J Barber; Douglas R Green; Donald D Newmeyer
The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol.
The Journal of cell biology 1999;147(4):809-22.
1999: Nigel Waterhouse; Douglas R Green
Mitochondria and apoptosis: HQ or high-security prison?
Journal of clinical immunology 1999;19(6):378-87.
1999: T Lin; H Yoshida; G Matsuzaki; SR Guehler; K Nomoto; Terrence Anthony Barrett; Douglas R Green
Autospecific gammadelta thymocytes that escape negative selection find sanctuary in the intestine.
The Journal of clinical investigation 1999;104(9):1297-305.
1999: BB Wolf; Martin Schuler; F Echeverri; Douglas R Green
Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation.
The Journal of biological chemistry 1999;274(43):30651-6.
1999: BB Wolf; Joshua C Goldstein; Henning Stennicke; Helen M Beere; Gustavo Amarante-Mendes; Guy S Salvesen; Douglas R Green
Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation.
Blood 1999;94(5):1683-92.
1999: DM Finucane; Nigel Waterhouse; Gustavo Amarante-Mendes; Thomas G Cotter; Douglas R Green
Collapse of the inner mitochondrial transmembrane potential is not required for apoptosis of HL60 cells.
Experimental cell research 1999;251(1):166-74.
1999: Ella Bossy-Wetzel; Douglas R Green
Apoptosis: checkpoint at the mitochondrial frontier.
Mutation research 1999;434(3):243-51.
1999: BB Wolf; Douglas R Green
Suicidal tendencies: apoptotic cell death by caspase family proteinases.
The Journal of biological chemistry 1999;274(29):20049-52.
1999: Ella Bossy-Wetzel; Douglas R Green
Caspases induce cytochrome c release from mitochondria by activating cytosolic factors.
The Journal of biological chemistry 1999;274(25):17484-90.
1999: Z Han; David L Boyle; Y Shi; Douglas R Green; Gary S Firestein
Dominant-negative p53 mutations in rheumatoid arthritis.
Arthritis and rheumatism 1999;42(6):1088-92.
1999: Douglas R Green
Harm's way: polyglutamine repeats and the activation of an apoptotic pathway.
Neuron 1999;22(3):416-7.
1999: Xiao-Ming Sun; Marion MacFarlane; J Zhuang; BB Wolf; Douglas R Green; Gerald M Cohen
Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis.
The Journal of biological chemistry 1999;274(8):5053-60.
1999: EA Slee; M T Harte; Ruth M Kluck; BB Wolf; C A Casiano; Donald D Newmeyer; Hong-Gang Wang; John C Reed; D W Nicholson; E S Alnemri; Douglas R Green; Seamus Martin
Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner.
The Journal of cell biology 1999;144(2):281-92.
1999: DM Finucane; Ella Bossy-Wetzel; Nigel Waterhouse; Thomas G Cotter; Douglas R Green
Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL.
The Journal of biological chemistry 1999;274(4):2225-33.
1999: Laurent Genestier; S Kasibhatla; Thomas Brunner; Douglas R Green
Transforming growth factor beta1 inhibits Fas ligand expression and subsequent activation-induced cell death in T cells via downregulation of c-Myc.
The Journal of experimental medicine 1999;189(2):231-9.
1999: S Kasibhatla; Laurent Genestier; Douglas R Green
Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor kappaB.
The Journal of biological chemistry 1999;274(2):987-92.
1998: X Yang; Henning Stennicke; Baikun Wang; Douglas R Green; R U Jänicke; A Srinivasan; Prem Seth; Guy S Salvesen; Christopher J Froelich
Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.
The Journal of biological chemistry 1998;273(51):34278-83.
1998: Nigel Waterhouse; DM Finucane; Douglas R Green; J S Elce; S Kumar; E S Alnemri; G Litwack; Kum Kum Khanna; Martin F Lavin; Dianne Watters
Calpain activation is upstream of caspases in radiation-induced apoptosis.
Cell death and differentiation 1998;5(12):1051-61.
1998: E Bonfoco; Patrick M Stuart; Thomas Brunner; Tesu Lin; Thomas Griffith; Y Gao; H Nakajima; P A Henkart; Thomas A Ferguson; Douglas R Green
Inducible nonlymphoid expression of Fas ligand is responsible for superantigen-induced peripheral deletion of T cells.
Immunity 1998;9(5):711-20.
1998: Henning Stennicke; JM Jürgensmeier; Hwain Shin; Quinn Deveraux; BB Wolf; X Yang; Qiao Zhou; H Michael Ellerby; Lisa M Ellerby; Dale E Bredesen; Douglas R Green; John C Reed; Christopher J Froelich; Guy S Salvesen
Pro-caspase-3 is a major physiologic target of caspase-8.
The Journal of biological chemistry 1998;273(42):27084-90.
1998: Douglas R Green
Apoptotic pathways: the roads to ruin.
Cell 1998;94(6):695-8.
1998: Douglas R Green; J C Reed
Mitochondria and apoptosis.
Science (New York, N.Y.) 1998;281(5381):1309-12.
1998: Gustavo Amarante-Mendes; DM Finucane; Seamus Martin; Thomas G Cotter; Guy S Salvesen; Douglas R Green
Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death.
Cell death and differentiation 1998;5(4):298-306.
1998: S Kasibhatla; Thomas Brunner; Laurent Genestier; F Echeverri; Artin Mahboubi; Douglas R Green
DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1.
Molecular cell 1998;1(4):543-51.
1998: Gustavo Amarante-Mendes; AJ McGahon; W K Nishioka; Daniel E H Afar; Owen N Witte; Douglas R Green
Bcl-2-independent Bcr-Abl-mediated resistance to apoptosis: protection is correlated with up regulation of Bcl-xL.
Oncogene 1998;16(11):1383-90.
1998: M von Willebrand; Scott Williams; M Saxena; J Gilman; Pankaj Tailor; Thomas Jascur; Gustavo Amarante-Mendes; Douglas R Green; Tomas Mustelin
Modification of phosphatidylinositol 3-kinase SH2 domain binding properties by Abl- or Lck-mediated tyrosine phosphorylation at Tyr-688.
The Journal of biological chemistry 1998;273(7):3994-4000.
1998: T Lin; Thomas Brunner; B Tietz; J Madsen; E Bonfoco; M Reaves; M Huflejt; Douglas R Green
Fas ligand- mediated killing by intestinal intraepithelial lymphocytes. Participation in intestinal graft-versus-host disease.
The Journal of clinical investigation 1998;101(3):570-7.
1998: Ella Bossy-Wetzel; Donald D Newmeyer; Douglas R Green
Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.
The EMBO journal 1998;17(1):37-49.
1998: Douglas R Green; Gustavo Amarante-Mendes
The point of no return: mitochondria, caspases, and the commitment to cell death.
Results and problems in cell differentiation 1998;24():45-61.
1997: Douglas R Green
A Myc-induced apoptosis pathway surfaces.
Science (New York, N.Y.) 1997;278(5341):1246-7.
1997: Gustavo Amarante-Mendes; Thomas Jascur; W K Nishioka; Tomas Mustelin; Douglas R Green
Bcr - Abl-mediated resistance to apoptosis is independent of PI 3-kinase activity.
Cell death and differentiation 1997;4(7):548-54.
1997: H Michael Ellerby; Seamus Martin; Lisa M Ellerby; S S Naiem; Shahrooz Rabizadeh; Guy S Salvesen; C A Casiano; N R Cashman; Douglas R Green; Dale E Bredesen
Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(16):6165-78.
1997: Ruth M Kluck; Seamus Martin; B M Hoffman; J S Zhou; Douglas R Green; Donald D Newmeyer
Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system.
The EMBO journal 1997;16(15):4639-49.
1997: Douglas R Green; Carl Ware
Fas-ligand: privilege and peril.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(12):5986-90.
1997: Ruth M Kluck; Ella Bossy-Wetzel; Douglas R Green; Donald D Newmeyer
The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis.
Science (New York, N.Y.) 1997;275(5303):1132-6.
1997: AJ McGahon; D G Brown; Seamus Martin; Gustavo Amarante-Mendes; Thomas G Cotter; G M Cohen; Douglas R Green
Downregulation of Bcr-Abl in K562 cells restores susceptibility to apoptosis: characterization of the apoptotic death.
Cell death and differentiation 1997;4(2):95-104.
1996: Seamus Martin; DM Finucane; Gustavo Amarante-Mendes; G A O'Brien; Douglas R Green
Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity.
The Journal of biological chemistry 1996;271(46):28753-6.
1996: Thomas Brunner; N J Yoo; Thomas Griffith; Thomas A Ferguson; Douglas R Green
Regulation of CD95 ligand expression: a key element in immune regulation?
Behring Institute Mitteilungen 1996;(97):161-74.
1996: Douglas R Green; Seamus Martin
Educational Corner: The ICE/Ced-3-family proteases as the apoptotic executioner.
Cell death and differentiation 1996;3(3):339-40.
1996: Thomas Griffith; X Yu; J M Herndon; Douglas R Green; Thomas A Ferguson
CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance.
Immunity 1996;5(1):7-16.
1996: Thomas Brunner; N J Yoo; D LaFace; Carl Ware; Douglas R Green
Activation-induced cell death in murine T cell hybridomas. Differential regulation of Fas (CD95) versus Fas ligand expression by cyclosporin A and FK506.
International immunology 1996;8(7):1017-26.
1996: Seamus Martin; Gustavo Amarante-Mendes; L Shi; T H Chuang; C A Casiano; G A O'Brien; P Fitzgerald; E M Tan; G M Bokoch; A H Greenberg; Douglas R Green
The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.
The EMBO journal 1996;15(10):2407-16.
1996: Seamus Martin; Gustavo Amarante-Mendes; Douglas R Green
Cytotoxic lymphocyte killing enters the ice age.
Advances in experimental medicine and biology 1996;406():29-37.
1996: Douglas R Green; AJ McGahon; Seamus Martin
Regulation of apoptosis by oncogenes.
Journal of cellular biochemistry 1996;60(1):33-8.
1995: T Onda; D LaFace; Gottfried Baier; Thomas Brunner; N Honma; T Mikayama; A Altman; Douglas R Green
A phage display system for detection of T cell receptor-antigen interactions.
Molecular immunology 1995;32(17-18):1387-97.
1995: Thomas Griffith; T Brunner; S M Fletcher; Douglas R Green; Thomas A Ferguson
Fas ligand-induced apoptosis as a mechanism of immune privilege.
Science (New York, N.Y.) 1995;270(5239):1189-92.
1995: Seamus Martin; C P Reutelingsperger; AJ McGahon; J A Rader; R C van Schie; D M LaFace; Douglas R Green
Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.
The Journal of experimental medicine 1995;182(5):1545-56.
1995: Seamus Martin; Donald D Newmeyer; S Mathias; D M Farschon; Hong-Gang Wang; John C Reed; Richard Kolesnick; Douglas R Green
Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis.
The EMBO journal 1995;14(21):5191-200.
1995: Reid P Bissonnette; Thomas Brunner; S B Lazarchik; N J Yoo; Marcus F Boehm; Douglas R Green; Richard A Heyman
9-cis retinoic acid inhibition of activation-induced apoptosis is mediated via regulation of fas ligand and requires retinoic acid receptor and retinoid X receptor activation.
Molecular and cellular biology 1995;15(10):5576-85.
1995: AJ McGahon; W K Nishioka; Seamus Martin; Artin Mahboubi; Thomas G Cotter; Douglas R Green
Regulation of the Fas apoptotic cell death pathway by Abl.
The Journal of biological chemistry 1995;270(38):22625-31.
1995: R J Mogil; L Radvanyi; R Gonzalez-Quintial; R Miller; G Mills; A N Theofilopoulos; Douglas R Green
Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo.
International immunology 1995;7(9):1451-8.
1995: Seamus Martin; Douglas R Green
Protease activation during apoptosis: death by a thousand cuts?
Cell 1995;82(3):349-52.
1995: Seamus Martin; AJ McGahon; W K Nishioka; D LaFace; X Guo; J Th'ng; E M Bradbury; Douglas R Green
p34cdc2 and apoptosis.
Science (New York, N.Y.) 1995;269(5220):106-7.
1995: T Onda; H Messier; R Bissonette; F Echeverri; Gottfried Baier; Arun Fotedar; Douglas R Green
Antigen-specific immunoregulatory activity of a T cell receptor alpha chain generated by expression PCR.
International archives of allergy and immunology 1995;107(1-3):356-8.
1995: T Onda; Thomas Brunner; H Messier; Reid P Bissonnette; F Echeverri; Gottfried Baier; Arun Fotedar; Douglas R Green
Immunoregulatory activity of a T-cell receptor alpha chain demonstrated by in vitro transcription and translation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):3004-8.
1995: Seamus Martin; G A O'Brien; W K Nishioka; AJ McGahon; Artin Mahboubi; T C Saido; Douglas R Green
Proteolysis of fodrin (non-erythroid spectrin) during apoptosis.
The Journal of biological chemistry 1995;270(12):6425-8.
1995: Seamus Martin; Douglas R Green
Apoptosis during HIV infection. A cytopathic effect of HIV or an important host-defense mechanism against viruses in general?
Advances in experimental medicine and biology 1995;374():129-38.
1995: AJ McGahon; Seamus Martin; Reid P Bissonnette; Artin Mahboubi; Y Shi; R J Mogil; W K Nishioka; Douglas R Green
The end of the (cell) line: methods for the study of apoptosis in vitro.
Methods in cell biology 1995;46():153-85.
1994: Reid P Bissonnette; AJ McGahon; Artin Mahboubi; Douglas R Green
Functional Myc-Max heterodimer is required for activation-induced apoptosis in T cell hybridomas.
The Journal of experimental medicine 1994;180(6):2413-8.
1994: Douglas R Green; Artin Mahboubi; W Nishioka; S Oja; F Echeverri; Y Shi; J Glynn; Y Yang; J Ashwell; Reid P Bissonnette
Promotion and inhibition of activation-induced apoptosis in T-cell hybridomas by oncogenes and related signals.
Immunological reviews 1994;142():321-42.
1994: AJ McGahon; Reid P Bissonnette; Manfred Schmitt; K M Cotter; Douglas R Green; Thomas G Cotter
BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death.
Blood 1994;83(5):1179-87.
1994: R J Mogil; Y Shi; Reid P Bissonnette; P Bromley; I Yamaguchi; Douglas R Green
Role of DNA fragmentation in T cell activation-induced apoptosis in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(4):1674-83.
1994: Douglas R Green; Reid P Bissonnette; Thomas G Cotter
Apoptosis and cancer.
Important advances in oncology 1994;():37-52.
1993: Douglas R Green; D R Webb
Saying the 'S' word in public.
Immunology today 1993;14(11):523-5.
1993: C D Helgason; L Shi; A H Greenberg; Y Shi; P Bromley; Thomas G Cotter; Douglas R Green; R Chris Bleackley
DNA fragmentation induced by cytotoxic T lymphocytes can result in target cell death.
Experimental cell research 1993;206(2):302-10.
1992: Douglas R Green; Reid P Bissonnette; J M Glynn; Y Shi
Activation-induced apoptosis in lymphoid systems.
Seminars in immunology 1992;4(6):379-88.
1992: Douglas R Green; T G Cotter
Introduction: apoptosis in the immune system.
Seminars in immunology 1992;4(6):355-62.
1992: Douglas R Green; H Zheng; Y Shi
Antisense oligodeoxynucleotides as probes of T-lymphocyte gene function.
Annals of the New York Academy of Sciences 1992;660():193-203.
1992: Reid P Bissonnette; F Echeverri; Artin Mahboubi; Douglas R Green
Apoptotic cell death induced by c-myc is inhibited by bcl-2.
Nature 1992;359(6395):552-4.
1992: Y Shi; J M Glynn; L J Guilbert; Thomas G Cotter; Reid P Bissonnette; Douglas R Green
Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas.
Science (New York, N.Y.) 1992;257(5067):212-4.
1992: Thomas G Cotter; J M Glynn; F Echeverri; Douglas R Green
The induction of apoptosis by chemotherapeutic agents occurs in all phases of the cell cycle.
Anticancer research 1992;12(3):773-9.
1992: Thomas G Cotter; S V Lennon; J M Glynn; Douglas R Green
Microfilament-disrupting agents prevent the formation of apoptotic bodies in tumor cells undergoing apoptosis.
Cancer research 1992;52(4):997-1005.
1991: Douglas R Green; Reid P Bissonnette; H G Zheng; T Onda; F Echeverri; R J Mogil; J K Steele; M Voralia; Arun Fotedar
Immunoregulatory activity of the T-cell receptor alpha chain demonstrated by retroviral gene transfer.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8475-9.
1991: Y F Shi; Reid P Bissonnette; Nollaig A Parfrey; M Szalay; R T Kubo; Douglas R Green
In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(10):3340-6.
1991: Reid P Bissonnette; H G Zheng; R T Kubo; Bhagirath Singh; Douglas R Green
A T helper cell hybridoma produces an antigen-specific regulatory activity. Relationship to the T cell receptor by serology and antigenic fine specificity.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(9):2898-907.
1990: Alan Friedman; Wlodzimierz Ptak; E Brewer; Douglas R Green; P A Reuter; Patrick M Flood
Generation of a T-cell hybridoma producing a contrasuppressor factor for contact sensitivity.
Immunology 1990;71(2):282-9.
1990: Y F Shi; M G Szalay; L Paskar; B M Sahai; M Boyer; Bhagirath Singh; Douglas R Green
Activation-induced cell death in T cell hybridomas is due to apoptosis. Morphologic aspects and DNA fragmentation.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(9):3326-33.
1990: Michel Sadelain; Douglas R Green; T G Wegmann
Host natural suppressor activity regulates hemopoietic engraftment kinetics in antibody-conditioned recipient mice.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(5):1729-36.
1989: Y F Shi; B M Sahai; Douglas R Green
Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes.
Nature 1989;339(6226):625-6.
1989: H Zheng; B M Sahai; P Kilgannon; Arun Fotedar; Douglas R Green
Specific inhibition of cell-surface T-cell receptor expression by antisense oligodeoxynucleotides and its effect on the production of an antigen-specific regulatory T-cell factor.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(10):3758-62.
1989: Michel Sadelain; M Voralia; Douglas R Green; T G Wegmann
The role of natural suppressor and natural killer activities in resistance to hemopoietic transplantation in unirradiated hosts.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(7):2270-8.
1989: Douglas R Green; H Zheng
Antigen-specific regulatory T-cell factors and the T-cell receptor.
Research in immunology 1989;140(3):294-8; discussion 339-45.
1989: Alan Friedman; Wlodzimierz Ptak; J Freedman; Douglas R Green; Patrick M Flood
Prevention of tumor growth and enhancement of cell-mediated immunity by an antigen-specific contrasuppressor factor from a T cell hybridoma.
Progress in clinical and biological research 1989;288():281-8.
1989: Douglas R Green; A Friedman; Wlodzimierz Ptak; J McGhee; Patrick M Flood
Contrasuppression, tolerance, and tumor immunity.
Progress in clinical and biological research 1989;288():245-58.
1989: B Chue; Thomas A Ferguson; K D Beaman; S J Rosenman; Robert E Cone; Patrick M Flood; Douglas R Green
An approach to the unification of suppressor T cell circuits: a simplified assay for the induction of suppression by T cell-derived, antigen-binding molecules (T-ABM).
Cellular immunology 1989;118(1):30-40.
1988: R J Mogil; C L Patton; Douglas R Green
An immunogenic antigen of murine Plasmodium yoelii 17X associates with class I MHC glycoproteins.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(1):258-64.
1988: Robert E Cone; H G Zheng; B Chue; K Beaman; T Ferguson; Douglas R Green
T cell-derived antigen binding molecules (TABM): molecular and functional properties.
International reviews of immunology 1988;3(3):205-28.
1988: H Zheng; M Boyer; Arun Fotedar; Bhagirath Singh; Douglas R Green
An antigen-specific helper T cell hybridoma produces an antigen-specific suppressor inducer molecule with identical antigenic fine specificity. Implications for the antigen recognition and function of helper and suppressor inducer T cells.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(5):1351-8.
1988: Douglas R Green; J McGhee; Wlodzimierz Ptak
Contrasuppression and the control of microenvironmental immune responses.
Monographs in allergy 1988;24():236-43.
1988: Douglas R Green; B Chue; Patrick M Flood
Induction of contrasuppression is restricted by genes mapping to the IgH locus.
Immunologic research 1988;7(1):82-92.
1988: Wlodzimierz Ptak; A Friedman; M Bereta; J Marcinkiewicz; B Horvat; P Reuter; Douglas R Green; Patrick M Flood
The role of contrasuppressor T cells in the adoptive transfer of contact sensitivity responses to picryl chloride.
Immunologic research 1988;7(1):1-11.
1987: Douglas R Green; N Wang; H Zheng
A suppressor-inducer factor produced by burn trauma-associated T cells.
The Journal of burn care & rehabilitation 1987;8(6):521-6.
1987: R J Mogil; C L Patton; Douglas R Green
Cellular subsets involved in cell-mediated immunity to murine Plasmodium yoelii 17X malaria.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(6):1933-9.
1987: Douglas R Green; R Marcotte; N D Wang; H G Zheng
Immunoregulatory T cells and immunodeficiency.
Progress in clinical and biological research 1987;246():183-90.
1987: Douglas R Green; B Chue; H G Zheng; Thomas A Ferguson; K D Beaman; Patrick M Flood
A helper T cell clone produces an antigen-specific molecule (T-ABM) which functions in the induction of suppression.
The Journal of molecular and cellular immunology : JMCI 1987;3(2):95-108.
1985: Wlodzimierz Ptak; M Bereta; M Ptak; G M Iverson; Douglas R Green
Suppression and contrasuppression in the induction of contact sensitivity by the administration of cellbound antigen-antibody complexes.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(4):2312-8.
1984: Douglas R Green; M Horowitz; T Ferguson; B Chue; Patrick M Flood
Immunoregulatory T cell pathways: the helper T cell clone as target.
Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand 1984;2(2):318-24.
1984: Wlodzimierz Ptak; M Bereta; M Ptak; R K Gershon; Douglas R Green
Antigen-specific T contrasuppressor factor in cell-mediated immunity: interactions leading to eradication of the tolerant state.
Journal of immunology (Baltimore, Md. : 1950) 1984;133(3):1124-30.
1984: Wlodzimierz Ptak; M Bereta; J Marcinkiewicz; R K Gershon; Douglas R Green
Production of antigen-specific contrasuppressor cells and factor, and their use in augmentation of cell-mediated immunity.
Journal of immunology (Baltimore, Md. : 1950) 1984;133(2):623-8.
1983: Douglas R Green; B Chue; R K Gershon
Discrimination of 2 types of suppressor T cells by cell surface phenotype and by function: the ability to regulate the contrasuppressor circuit.
The Journal of molecular and cellular immunology : JMCI 1983;1(1):19-30.