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Kim Green

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Kara M Neely Kayala; Ken C Walls; George D Dickinson; Kim N Green; Anet Minassian; Frank M LaFerla
Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: implications for lysosomal function.
Frank M LaFerla; Kim N Green
Animal models of Alzheimer disease.
Ken Carlson Walls; Nineli Zadourian; Suhail Rasool; Mathew Blurton-Jones; Pinar Coskun; Kristine Freude; Jose-Luis Gallegos-Perez; Kim N Green; Frank M LaFerla
Swedish Alzheimer mutation induces mitochondrial dysfunction mediated by HSP60 mislocalization of amyloid precursor protein (APP) and beta-amyloid.

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All Publications

2012: Kara M Neely Kayala; Ken C Walls; George D Dickinson; Kim N Green; Anet Minassian; Frank M LaFerla
Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: implications for lysosomal function.
Brain research 2012;1489():8-16.
2012: Frank M LaFerla; Kim N Green
Animal models of Alzheimer disease.
Cold Spring Harbor perspectives in medicine 2012;2(11):.
2012: Ken Carlson Walls; Nineli Zadourian; Suhail Rasool; Mathew Blurton-Jones; Pinar Coskun; Kristine Freude; Jose-Luis Gallegos-Perez; Kim N Green; Frank M LaFerla
Swedish Alzheimer mutation induces mitochondrial dysfunction mediated by HSP60 mislocalization of amyloid precursor protein (APP) and beta-amyloid.
The Journal of biological chemistry 2012;287(36):30317-27.
2012: Rodrigo Medeiros; Achim Moeller; David Baglietto-Vargas; Meredith A Chabrier; David Cheng; Kim N Green; Masashi Kitazawa; Andreas Kling; Frank M LaFerla
Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.
The American journal of pathology 2012;181(2):616-25.
2012: Maya A Koike; Bernard Choi; Kim N Green; Alexander J Lin; Elaine Nguyen; Jonathan Pham; Rombod Rahimian; Bruce J Tromberg; James J Yeh; Frank M LaFerla
APP knockout mice experience acute mortality as the result of ischemia.
PloS one 2012;7(8):e42665.
2012: Nicholas A Castello; Kim N Green; Frank M LaFerla
Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology.
PloS one 2012;7(8):e39566.
2011: Kara M Neely; Kim N Green
Presenilins mediate efficient proteolysis via the autophagosome-lysosome system.
Autophagy 2011;7(6):664-5.
2011: M A Koike; F G Garcia; M Kitazawa; Kim N Green; F M Laferla
Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia.
Neuroscience letters 2011;495(1):55-9.
2011: Kim N Green; Hasan Khashwji; Tatiana Estrada; Frank M LaFerla
ST101 induces a novel 17 kDa APP cleavage that precludes Aβ generation in vivo.
Annals of neurology 2011;69(5):831-44.
2011: Kara M Neely; Kim N Green; Frank M LaFerla
Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(8):2781-91.
2010: Maya A Koike; Kim N Green; Mathew Blurton-Jones; Frank M LaFerla
Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.
The American journal of pathology 2010;177(1):300-10.
2010: Hilda Martinez-Coria; Kim N Green; Lauren M Billings; Masashi Kitazawa; Miriam Albrecht; Gerhard Rammes; Chris G Parsons; Sandeep Gupta; Pradeep Banerjee; Frank M LaFerla
Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.
The American journal of pathology 2010;176(2):870-80.
2010: Anna Parachikova; Kim N Green; Curt Hendrix; Frank M LaFerla
Formulation of a medical food cocktail for Alzheimer's disease: beneficial effects on cognition and neuropathology in a mouse model of the disease.
PloS one 2010;5(11):e14015.
2010: Anna Parachikova; Vitaly Vasilevko; David H Cribbs; Frank M LaFerla; Kim N Green
Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation.
Journal of Alzheimer's disease : JAD 2010;21(2):527-42.
2009: Leslie Michels Thompson; Charity T Aiken; Linda S Kaltenbach; Namita Agrawal; Katalin Illes; Ali Khoshnan; Marta Martinez-Vincente; Montserrat Arrasate; Jacqueline Gire O'Rourke; Hasan Khashwji; Tamas Lukacsovich; Ya-Zhen Zhu; Alice L Lau; Ashish Massey; Michael R Hayden; Scott O Zeitlin; Steven Finkbeiner; Kim N Green; Frank M LaFerla; Gillian P Bates; Lan Huang; Paul H Patterson; Donald C Lo; Ana Maria Cuervo; J Lawrence Marsh; Joan S Steffan
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.
The Journal of cell biology 2009;187(7):1083-99.
2009: Kim N Green
Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology.
Journal of cellular and molecular medicine 2009;13(9A):2787-99.
2009: Mathew Blurton-Jones; Masashi Kitazawa; Hilda Martinez-Coria; Nicholas A Castello; Franz-Josef Müller; Jeanne F Loring; Tritia R Yamasaki; Wayne W Poon; Kim N Green; Frank M LaFerla
Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(32):13594-9.
2009: Debbi A Morrissette; Anna Parachikova; Kim N Green; Frank M LaFerla
Relevance of transgenic mouse models to human Alzheimer disease.
The Journal of biological chemistry 2009;284(10):6033-7.
2008: Kim N Green; Joan S Steffan; Hilda Martinez-Coria; Xuemin Sun; Steven S. Schreiber; Leslie Michels Thompson; Frank M LaFerla
Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(45):11500-10.
2008: Bertrand P Tseng; Kim N Green; Julie L Chan; Mathew Blurton-Jones; Frank M LaFerla
Abeta inhibits the proteasome and enhances amyloid and tau accumulation.
Neurobiology of aging 2008;29(11):1607-18.
2008: Kim N Green; Frank M LaFerla
Linking calcium to Abeta and Alzheimer's disease.
Neuron 2008;59(2):190-4.
2008: Kim N Green; Angelo Demuro; Yama Akbari; Brian D Hitt; Ian F Smith; Ian Parker; Frank M LaFerla
SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production.
The Journal of cell biology 2008;181(7):1107-16.
2007: Lani K Clinton; Lauren M Billings; Kim N Green; Antonella Caccamo; Jerry Ngo; Salvatore Oddo; James L McGaugh; Frank M LaFerla
Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice.
Neurobiology of disease 2007;28(1):76-82.
2007: Frank M LaFerla; Kim N Green; Salvatore Oddo
Intracellular amyloid-beta in Alzheimer's disease.
Nature reviews. Neuroscience 2007;8(7):499-509.
2007: Kim N Green; Hilda Martinez-Coria; Hasan Khashwji; Eileen B Hall; Karin A Yurko-Mauro; Lorie Ellis; Frank M LaFerla
Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(16):4385-95.
2007: Lauren M Billings; Kim N Green; James L McGaugh; Frank M LaFerla
Learning decreases A beta*56 and tau pathology and ameliorates behavioral decline in 3xTg-AD mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(4):751-61.
2007: Kim N Green; Ian F Smith; Frank M LaFerla
Role of calcium in the pathogenesis of Alzheimer's disease and transgenic models.
Sub-cellular biochemistry 2007;45():507-21.
2006: Kim N Green; Lauren M Billings; Benno Roozendaal; James L McGaugh; Frank M LaFerla
Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(35):9047-56.
2006: Masashi Kitazawa; Kim N Green; Antonella Caccamo; Frank M LaFerla
Genetically augmenting Abeta42 levels in skeletal muscle exacerbates inclusion body myositis-like pathology and motor deficits in transgenic mice.
The American journal of pathology 2006;168(6):1986-97.
2006: Antonella Caccamo; Salvatore Oddo; Lauren M Billings; Kim N Green; Hilda Martinez-Coria; Abraham Fisher; Frank M LaFerla
M1 receptors play a central role in modulating AD-like pathology in transgenic mice.
Neuron 2006;49(5):671-82.
2006: Salvatore Oddo; Antonella Caccamo; Ian F Smith; Kim N Green; Frank M LaFerla
A dynamic relationship between intracellular and extracellular pools of Abeta.
The American journal of pathology 2006;168(1):184-94.
2005: Chris Peers; Jason L Scragg; John P Boyle; Ian M Fearon; Shafeena C Taylor; Kim N Green; Nicola J Webster; Martin Ramsden; Hugh A Pearson
A central role for ROS in the functional remodelling of L-type Ca2+ channels by hypoxia.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2005;360(1464):2247-54.
2005: Masashi Kitazawa; Salvatore Oddo; Tritia R Yamasaki; Kim N Green; Frank M LaFerla
Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(39):8843-53.
2005: Ian F Smith; Brian Hitt; Kim N Green; Salvatore Oddo; Frank M LaFerla
Enhanced caffeine-induced Ca2+ release in the 3xTg-AD mouse model of Alzheimer's disease.
Journal of neurochemistry 2005;94(6):1711-8.
2005: Ian F Smith; Kim N Green; Frank M LaFerla
Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals.
Cell calcium 2005;38(3-4):427-37.
2005: Lauren M Billings; Salvatore Oddo; Kim N Green; James L McGaugh; Frank M LaFerla
Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice.
Neuron 2005;45(5):675-88.
2005: Salvatore Oddo; Antonella Caccamo; Kim N Green; Kevin Liang; Levina Tran; Yiling Chen; Frances M Leslie; Frank M LaFerla
Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):3046-51.
2004: Nicola J Webster; Kim N Green; Victoria J Settle; Chris Peers; Peter F T Vaughan
Altered processing of the amyloid precursor protein and decreased expression of ADAM 10 by chronic hypoxia in SH-SY5Y: no role for the stress-activated JNK and p38 signalling pathways.
Brain research. Molecular brain research 2004;130(1-2):161-9.
2004: Yama Akbari; Brian D Hitt; Michael Murphy; Nabil N Dagher; Bertrand P Tseng; Kim N Green; todd golde; Frank M LaFerla
Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity.
Biochemical and biophysical research communications 2004;322(4):1145-52.
2004: Ian F Smith; John P Boyle; Kim N Green; Hugh A Pearson; Chris Peers
Hypoxic remodelling of Ca2+ mobilization in type I cortical astrocytes: involvement of ROS and pro-amyloidogenic APP processing.
Journal of neurochemistry 2004;88(4):869-77.
2003: Chris Peers; Kim N Green; John P Boyle
Amyloid peptide-mediated hypoxic regulation of Ca2+ channels in PC12 cells.
Advances in experimental medicine and biology 2003;536():187-92.
2002: Nicola J Webster; Kim N Green; Chris Peers; Peter F T Vaughan
Altered processing of amyloid precursor protein in the human neuroblastoma SH-SY5Y by chronic hypoxia.
Journal of neurochemistry 2002;83(6):1262-71.
2002: Kim N Green; John P Boyle; Chris Peers
Hypoxia potentiates exocytosis and Ca2+ channels in PC12 cells via increased amyloid beta peptide formation and reactive oxygen species generation.
The Journal of physiology 2002;541(Pt 3):1013-23.
2002: Kim N Green; Chris Peers
Divergent pathways account for two distinct effects of amyloid beta peptides on exocytosis and Ca(2+) currents: involvement of ROS and NF-kappaB.
Journal of neurochemistry 2002;81(5):1043-51.
2001: Shafeena C Taylor; Kim N Green; Ian F Smith; Chris Peers
Prion protein fragment 106-126 potentiates catecholamine secretion from PC-12 cells.
American journal of physiology. Cell physiology 2001;281(6):C1850-7.
2001: Kim N Green; Chris Peers
Amyloid beta peptides mediate hypoxic augmentation of Ca(2+) channels.
Journal of neurochemistry 2001;77(3):953-6.
2001: Kim N Green; Shafeena C Taylor; Ian F Smith; Chris Peers
Differential coupling of voltage-gated Ca(2+) channels to catecholamine secretion from separate PC12 cell batches.
Neuroscience letters 2001;301(1):13-6.
2000: Shafeena C Taylor; Kim N Green; E Carpenter; Chris Peers
Protein kinase C evokes quantal catecholamine release from PC12 cells via activation of L-type Ca2+ channels.
The Journal of biological chemistry 2000;275(35):26786-91.