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David Greenblatt

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Anatomy

Microsomes, Liver

Chemicals & Drugs

Physiology

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Hydroxylation

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Umit Yasar; David J Greenblatt; Chantal Guillemette; Michael H Court
Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers.
David J Greenblatt; Jerold S Harmatz; Stephen C Harris; Margaret L Moline; Thomas Roth; Nikhilesh N Singh; Ram P Kapil
Comparison of pharmacokinetic profiles of zolpidem buffered sublingual tablet and zolpidem oral immediate-release tablet: results from a single-center, single-dose, randomized, open-label crossover study in healthy adults.
Michael J Hanley; Jerold S Harmatz; Gina Masse; Paul F Cancalon; Michael H Court; Gregory G Dolnikowski; David J Greenblatt
Effect of blueberry juice on clearance of buspirone and flurbiprofen in human volunteers.

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All Publications

2013: Umit Yasar; David J Greenblatt; Chantal Guillemette; Michael H Court
Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers.
The Journal of pharmacy and pharmacology 2013;65(6):874-83.
2013: David J Greenblatt; Jerold S Harmatz; Stephen C Harris; Margaret L Moline; Thomas Roth; Nikhilesh N Singh; Ram P Kapil
Comparison of pharmacokinetic profiles of zolpidem buffered sublingual tablet and zolpidem oral immediate-release tablet: results from a single-center, single-dose, randomized, open-label crossover study in healthy adults.
Clinical therapeutics 2013;35(5):604-11.
2013: Michael J Hanley; Jerold S Harmatz; Gina Masse; Paul F Cancalon; Michael H Court; Gregory G Dolnikowski; David J Greenblatt
Effect of blueberry juice on clearance of buspirone and flurbiprofen in human volunteers.
British journal of clinical pharmacology 2013;75(4):1041-52.
2013: Laurie P Volak; Vladimir Badmaev; David J Greenblatt; Michael J Hanley; Jerold S Harmatz; Suwagmani Hazarika; Muhammed Majeed; Gina Masse; Michael H Court
Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers.
British journal of clinical pharmacology 2013;75(2):450-62.
2012: David J Greenblatt; Gary K Zammit
Pharmacokinetic evaluation of eszopiclone: clinical and therapeutic implications.
Expert opinion on drug metabolism & toxicology 2012;8(12):1609-18.
2012: David J Greenblatt; Michael J Hanley; Jerold S Harmatz; Yanli Zhao; Paul F Cancalon; Chunxian Chen; Frederick G Gmitter
Mechanism-based inhibition of human Cytochrome P450-3A activity by grapefruit hybrids having low furanocoumarin content.
Xenobiotica; the fate of foreign compounds in biological systems 2012;42(12):1163-9.
2012: M J Hanley; Jerold S Harmatz; G Masse; Michael H Court; David J Greenblatt
Pomegranate juice and pomegranate extract do not impair oral clearance of flurbiprofen in human volunteers: divergence from in vitro results.
Clinical pharmacology and therapeutics 2012;92(5):651-7.
2012: Erin N Umberg; L K George Hsu; Richard I Shader; David J Greenblatt
From disordered eating to addiction: the "food drug" in bulimia nervosa.
Journal of clinical psychopharmacology 2012;32(3):376-89.
2012: David J Greenblatt; Thomas Roth
Zolpidem for insomnia.
Expert opinion on pharmacotherapy 2012;13(6):879-93.
2012: Howard A Smithline; Michael Donnino; David J Greenblatt
Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects.
BMC clinical pharmacology 2012;12():4.
2011: David J Greenblatt; Jerold S Harmatz; Rémy Luthringer; Jean-François Nedelec; Sarah Otmani; Sarah J Parent; Luc Staner; James K Walsh; Céline Francart; Corinne Staner
Pharmacokinetic profile of SKP-1041, a modified release formulation of zaleplon.
Biopharmaceutics & drug disposition 2011;32(9):489-97.
2011: Patrick Reddy; Immo Zdrojewski; Yiliang Zhu; Hartmut Derendorf; David Ellington; David J Greenblatt; Jerold S Harmatz; Sarah J Parent; Kevin Browne
Serum concentrations and clinical effects of atorvastatin in patients taking grapefruit juice daily.
British journal of clinical pharmacology 2011;72(3):434-41.
2011: Michael J Hanley; Paul Cancalon; Wilbur W Widmer; David J Greenblatt
The effect of grapefruit juice on drug disposition.
Expert opinion on drug metabolism & toxicology 2011;7(3):267-86.
2011: David J Greenblatt; Yanli Zhao; Karthik Venkatakrishnan; Su X Duan; Jerold S Harmatz; Sarah J Parent; Michael H Court; Lisa L Von Moltke
Mechanism of cytochrome P450-3A inhibition by ketoconazole.
The Journal of pharmacy and pharmacology 2011;63(2):214-21.
2011: David J Greenblatt; Jerold S Harmatz; Richard I Shader
Psychotropic drug prescribing in the United States: extent, costs, and expenditures.
Journal of clinical psychopharmacology 2011;31(1):1-3.
2010: David J Greenblatt; Karthik Venkatakrishnan; Jerold S Harmatz; Sarah J Parent; Lisa L Von Moltke
Sources of variability in ketoconazole inhibition of human cytochrome P450 3A in vitro.
Xenobiotica; the fate of foreign compounds in biological systems 2010;40(10):713-20.
2010: L Oleson; Lisa L Von Moltke; David J Greenblatt; Michael H Court
Identification of polymorphisms in the 3'-untranslated region of the human pregnane X receptor (PXR) gene associated with variability in cytochrome P450 3A (CYP3A) metabolism.
Xenobiotica; the fate of foreign compounds in biological systems 2010;40(2):146-62.
2010: Michael J Hanley; Darrell R. Abernethy; David J Greenblatt
Effect of obesity on the pharmacokinetics of drugs in humans.
Clinical pharmacokinetics 2010;49(2):71-87.
2009: David J Greenblatt; Diane E Peters; Lauren E Oleson; Jerold S Harmatz; Malcolm W MacNab; Noah Berkowitz; Miguel A Zinny; Michael H Court
Inhibition of oral midazolam clearance by boosting doses of ritonavir, and by 4,4-dimethyl-benziso-(2H)-selenazine (ALT-2074), an experimental catalytic mimic of glutathione oxidase.
British journal of clinical pharmacology 2009;68(6):920-7.
2009: David J Greenblatt
Analysis of drug interactions involving fruit beverages and organic anion-transporting polypeptides.
Journal of clinical pharmacology 2009;49(12):1403-7.
2009: Xi He; Leah M Hesse; Suwagmani Hazarika; Gina Masse; Jerold S Harmatz; David J Greenblatt; Michael H Court
Evidence for oxazepam as an in vivo probe of UGT2B15: oxazepam clearance is reduced by UGT2B15 D85Y polymorphism but unaffected by UGT2B17 deletion.
British journal of clinical pharmacology 2009;68(5):721-30.
2009: David J Greenblatt
Drug-drug noninteractions.
Cardiovascular therapeutics 2009;27(4):226-9.
2008: Tamsin Knox; Lauren Oleson; Lisa L Von Moltke; Rhonda C Kaufman; Christine Wanke; David J Greenblatt
Ritonavir greatly impairs CYP3A activity in HIV infection with chronic viral hepatitis.
Journal of acquired immune deficiency syndromes (1999) 2008;49(4):358-68.
2008: David J Greenblatt; Lisa L Von Moltke
Gender has a small but statistically significant effect on clearance of CYP3A substrate drugs.
Journal of clinical pharmacology 2008;48(11):1350-5.
2008: David J Greenblatt
Preparation of scientific reports on pharmacokinetic drug interaction studies.
Journal of clinical psychopharmacology 2008;28(4):369-73.
2008: Dora Farkas; David J Greenblatt
Influence of fruit juices on drug disposition: discrepancies between in vitro and clinical studies.
Expert opinion on drug metabolism & toxicology 2008;4(4):381-93.
2007: Michael D Perloff; Lisa L Von Moltke; Jeanne M Fahey; David J Greenblatt
Induction of P-glycoprotein expression and activity by ritonavir in bovine brain microvessel endothelial cells.
The Journal of pharmacy and pharmacology 2007;59(7):947-53.
2007: R M Cysneiros; Dora Farkas; Jerold S Harmatz; Lisa L Von Moltke; David J Greenblatt
Pharmacokinetic and pharmacodynamic interactions between zolpidem and caffeine.
Clinical pharmacology and therapeutics 2007;82(1):54-62.
2007: David J Greenblatt; Jerold S Harmatz; Aziz Karim
Age and gender effects on the pharmacokinetics and pharmacodynamics of ramelteon, a hypnotic agent acting via melatonin receptors MT1 and MT2.
Journal of clinical pharmacology 2007;47(4):485-96.
2007: Dora Farkas; Lauren E Oleson; Yanli Zhao; Jerold S Harmatz; Miguel A Zinny; Michael H Court; David J Greenblatt
Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450-3A activity: comparison with grapefruit juice.
Journal of clinical pharmacology 2007;47(3):286-94.
2007: Sheldon H Preskorn; David J Greenblatt; David A Flockhart; Yan Luo; Elke S Perloff; Jerold S Harmatz; Bryan Baker; Alisa Klick-Davis; Zeruesenay Desta; Tal Burt
Comparison of duloxetine, escitalopram, and sertraline effects on cytochrome P450 2D6 function in healthy volunteers.
Journal of clinical psychopharmacology 2007;27(1):28-34.
2006: David J Greenblatt; Eric Legangneux; Jerold S Harmatz; Estelle Weinling; Jon Freeman; Kathleen Rice; Gary K Zammit
Dynamics and kinetics of a modified-release formulation of zolpidem: comparison with immediate-release standard zolpidem and placebo.
Journal of clinical pharmacology 2006;46(12):1469-80.
2006: Jeanne M Fahey; Gary A Pritchard; Jyoti M Reddi; John Pratt; Jeffrey M Grassi; Richard I Shader; David J Greenblatt
The effect of chronic lorazepam administration in aging mice.
Brain research 2006;1118(1):13-24.
2006: Ping He; Michael H Court; David J Greenblatt; Lisa L Von Moltke
Factors influencing midazolam hydroxylation activity in human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(7):1198-207.
2006: Kirk M Bertelsen; David J Greenblatt; Lisa L Von Moltke
Apparent active transport of MDMA is not mediated by P-glycoprotein: a comparison with MDCK and Caco-2 monolayers.
Biopharmaceutics & drug disposition 2006;27(5):219-27.
2006: Leah M Hesse; David J Greenblatt; Lisa L Von Moltke; Michael H Court
Ritonavir has minimal impact on the pharmacokinetic disposition of a single dose of bupropion administered to human volunteers.
Journal of clinical pharmacology 2006;46(5):567-76.
2006: Kerry E Culm-Merdek; Lisa L Von Moltke; Lu Gan; Kelly A Horan; Robyn Reynolds; Jerold S Harmatz; Michael H Court; David J Greenblatt
Effect of extended exposure to grapefruit juice on cytochrome P450 3A activity in humans: comparison with ritonavir.
Clinical pharmacology and therapeutics 2006;79(3):243-54.
2006: David J Greenblatt; Richard A Leigh-Pemberton; Lisa L Von Moltke
In vitro interactions of water-soluble garlic components with human cytochromes p450.
The Journal of nutrition 2006;136(3 Suppl):806S-809S.
2006: David J Greenblatt; Lisa L Von Moltke; Yan Luo; Elke S Perloff; Kelly A Horan; Allison Bruce; Robyn C Reynolds; Jerold S Harmatz; Bharathi Avula; Ikhlas A Khan; Peter Goldman
Ginkgo biloba does not alter clearance of flurbiprofen, a cytochrome P450-2C9 substrate.
Journal of clinical pharmacology 2006;46(2):214-21.
2006: Jeanne M Fahey; Jeffrey M Grassi; Jyoti M Reddi; David J Greenblatt
Acute zolpidem administration produces pharmacodynamic and receptor occupancy changes at similar doses.
Pharmacology, biochemistry, and behavior 2006;83(1):21-7.
2006: David J Greenblatt; Lisa L Von Moltke; Elke S Perloff; Yan Luo; Jerold S Harmatz; Miguel A Zinny
Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies.
Clinical pharmacology and therapeutics 2006;79(1):125-33.
2005: David J Greenblatt; Philip D Blaskovich; E S Nuwayser; Jerold S Harmatz; Gengsheng Chen; Miguel A Zinny
Clonazepam pharmacokinetics: comparison of subcutaneous microsphere injection with multiple-dose oral administration.
Journal of clinical pharmacology 2005;45(11):1288-93.
2005: Kerry E Culm-Merdek; Lisa L Von Moltke; Jerold S Harmatz; David J Greenblatt
Fluvoxamine impairs single-dose caffeine clearance without altering caffeine pharmacodynamics.
British journal of clinical pharmacology 2005;60(5):486-93.
2005: David J Greenblatt; Lu Gan; Jerold S Harmatz; Richard I Shader
Pharmocokinetics and pharmacodynamics of single-dose triazolam: electroencephalography compared with the Digit-Symbol Substitution Test.
British journal of clinical pharmacology 2005;60(3):244-8.
2005: Elke S Perloff; Su X Duan; Paul R Skolnik; David J Greenblatt; Lisa L Von Moltke
Atazanavir: effects on P-glycoprotein transport and CYP3A metabolism in vitro.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(6):764-70.
2005: Soundararajan Krishnaswamy; Qin Hao; Abdul Al-Rohaimi; Leah M Hesse; Lisa L Von Moltke; David J Greenblatt; Michael H Court
UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: I. Identification of polymorphisms in the 5'-regulatory and exon 1 regions, and association with human liver UGT1A6 gene expression and glucuronidation.
The Journal of pharmacology and experimental therapeutics 2005;313(3):1331-9.
2005: Soundararajan Krishnaswamy; Qin Hao; Abdul Al-Rohaimi; Leah M Hesse; Lisa L Von Moltke; David J Greenblatt; Michael H Court
UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S).
The Journal of pharmacology and experimental therapeutics 2005;313(3):1340-6.
2005: Ping He; Michael H Court; David J Greenblatt; Lisa L Von Moltke
Genotype-phenotype associations of cytochrome P450 3A4 and 3A5 polymorphism with midazolam clearance in vivo.
Clinical pharmacology and therapeutics 2005;77(5):373-87.
2005: Karthik Venkatakrishnan; Kerry E Culm; Bruce L Ehrenberg; Jerold S Harmatz; Kathleen E Corbett; Joseph C Fleishaker; David J Greenblatt
Kinetics and dynamics of intravenous adinazolam, N-desmethyl adinazolam, and alprazolam in healthy volunteers.
Journal of clinical pharmacology 2005;45(5):529-37.
2005: David J Greenblatt; Lisa L Von Moltke
Interaction of warfarin with drugs, natural substances, and foods.
Journal of clinical pharmacology 2005;45(2):127-32.
2005: Monette M Cotreau; Lisa L Von Moltke; David J Greenblatt
The influence of age and sex on the clearance of cytochrome P450 3A substrates.
Clinical pharmacokinetics 2005;44(1):33-60.
2004: David J Greenblatt; Jerold S Harmatz; Lisa L Von Moltke; C Eugene Wright; Richard I Shader
Age and gender effects on the pharmacokinetics and pharmacodynamics of triazolam, a cytochrome P450 3A substrate.
Clinical pharmacology and therapeutics 2004;76(5):467-79.
2004: Tanios S Bekaii-Saab; Michael D Perloff; James L Weemhoff; David J Greenblatt; Lisa L Von Moltke
Interactions of tamoxifen, N-desmethyltamoxifen and 4-hydroxytamoxifen with P-glycoprotein and CYP3A.
Biopharmaceutics & drug disposition 2004;25(7):283-9.
2004: Lisa L Von Moltke; James L Weemhoff; Erdal Bedir; Ikhlas A Khan; Jerold S Harmatz; Peter Goldman; David J Greenblatt
Inhibition of human cytochromes P450 by components of Ginkgo biloba.
The Journal of pharmacy and pharmacology 2004;56(8):1039-44.
2004: Kiran C Patki; David J Greenblatt; Lisa L Von Moltke
Ethanol inhibits in-vitro metabolism of nifedipine, triazolam and testosterone in human liver microsomes.
The Journal of pharmacy and pharmacology 2004;56(8):963-6.
2004: Soundararajan Krishnaswamy; Qin Hao; Lisa L Von Moltke; David J Greenblatt; Michael H Court
Evaluation of 5-hydroxytryptophol and other endogenous serotonin (5-hydroxytryptamine) analogs as substrates for UDP-glucuronosyltransferase 1A6.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(8):862-9.
2004: Lisa L Von Moltke; Brian W Granda; Jeffrey M Grassi; Michael D Perloff; Daesety Vishnuvardhan; David J Greenblatt
Interaction of triazolam and ketoconazole in P-glycoprotein-deficient mice.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(8):800-4.
2004: Tim Mitin; Lisa L Von Moltke; Michael H Court; David J Greenblatt
Levothyroxine up-regulates P-glycoprotein independent of the pregnane X receptor.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(8):779-82.
2004: Michael H Court; Qin Hao; Soundararajan Krishnaswamy; Tanios Bekaii-Saab; Abdul Al-Rohaimi; Lisa L Von Moltke; David J Greenblatt
UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver.
The Journal of pharmacology and experimental therapeutics 2004;310(2):656-65.
2004: Jill S Warrington; Michael H Court; David J Greenblatt; Lisa L Von Moltke
Phenacetin and chlorzoxazone biotransformation in aging male Fischer 344 rats.
The Journal of pharmacy and pharmacology 2004;56(6):819-25.
2004: David J Greenblatt; Bruce L Ehrenberg; Kerry E Culm; Joseph M Scavone; Kathleen E Corbett; Hylar L Friedman; Jerold S Harmatz; Richard I Shader
Kinetics and EEG effects of midazolam during and after 1-minute, 1-hour, and 3-hour intravenous infusions.
Journal of clinical pharmacology 2004;44(6):605-11.
2004: Jill S Warrington; David J Greenblatt; Lisa L Von Moltke
Role of CYP3A enzymes in the biotransformation of triazolam in rat liver.
Xenobiotica; the fate of foreign compounds in biological systems 2004;34(5):463-71.
2004: Jill S Warrington; David J Greenblatt; Lisa L Von Moltke
The effect of age on P-glycoprotein expression and function in the Fischer-344 rat.
The Journal of pharmacology and experimental therapeutics 2004;309(2):730-6.
2004: Jill S Warrington; David J Greenblatt; Lisa L Von Moltke
Age-related differences in CYP3A expression and activity in the rat liver, intestine, and kidney.
The Journal of pharmacology and experimental therapeutics 2004;309(2):720-9.
2004: Leah M Hesse; Ping He; Soundararajan Krishnaswamy; Qin Hao; Kirk Hogan; Lisa L Von Moltke; David J Greenblatt; Michael H Court
Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes.
Pharmacogenetics 2004;14(4):225-38.
2004: Kiran C Patki; Lisa L Von Moltke; Jerold S Harmatz; Leah M Hesse; Michael H Court; David J Greenblatt
Effect of age on in vitro triazolam biotransformation in male human liver microsomes.
The Journal of pharmacology and experimental therapeutics 2004;308(3):874-9.
2004: Michael D Perloff; Lisa L Von Moltke; David J Greenblatt
Ritonavir and dexamethasone induce expression of CYP3A and P-glycoprotein in rats.
Xenobiotica; the fate of foreign compounds in biological systems 2004;34(2):133-50.
2003: Jill S Warrington; Lisa L Von Moltke; Jerold S Harmatz; Richard I Shader; David J Greenblatt
The effect of age on sildenafil biotransformation in rat and mouse liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(11):1306-9.
2003: Lisa L Von Moltke; David J Greenblatt
Medication dependence and anxiety.
Dialogues in clinical neuroscience 2003;5(3):237-45.
2003: Leah M Hesse; Yumiko Sakai; Daesety Vishnuvardhan; Albert P Li; Lisa L Von Moltke; David J Greenblatt
Effect of bupropion on CYP2B6 and CYP3A4 catalytic activity, immunoreactive protein and mRNA levels in primary human hepatocytes: comparison with rifampicin.
The Journal of pharmacy and pharmacology 2003;55(9):1229-39.
2003: Michael H Court; Soundararajan Krishnaswamy; Qin Hao; Su X Duan; Christopher J Patten; Lisa L Von Moltke; David J Greenblatt
Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(9):1125-33.
2003: Joel O Olubodun; Hermann R Ochs; Lisa L Von Moltke; Ronenn Roubenoff; Leah M Hesse; Jerold S Harmatz; Richard I Shader; David J Greenblatt
Pharmacokinetic properties of zolpidem in elderly and young adults: possible modulation by testosterone in men.
British journal of clinical pharmacology 2003;56(3):297-304.
2003: Michael D Perloff; Elke Störmer; Lisa L Von Moltke; David J Greenblatt
Rapid assessment of P-glycoprotein inhibition and induction in vitro.
Pharmaceutical research 2003;20(8):1177-83.
2003: David J Greenblatt; Lisa L Von Moltke; Jerold S Harmatz; Gengsheng Chen; James L Weemhoff; Cheng Jen; Charles J Kelley; Barbara W LeDuc; Miguel A Zinny
Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice.
Clinical pharmacology and therapeutics 2003;74(2):121-9.
2003: Kiran C Patki; Lisa L Von Moltke; David J Greenblatt
In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(7):938-44.
2003: Daesety Vishnuvardhan; Lisa L Moltke; Clemens Richert; David J Greenblatt
Lopinavir: acute exposure inhibits P-glycoprotein; extended exposure induces P-glycoprotein.
AIDS (London, England) 2003;17(7):1092-4.
2003: Michael D Perloff; Lisa L Von Moltke; David J Greenblatt
Differential metabolism of midazolam in mouse liver and intestine microsomes: a comparison of cytochrome P450 activity and expression.
Xenobiotica; the fate of foreign compounds in biological systems 2003;33(4):365-77.
2003: David J Greenblatt; Lisa L Von Moltke; Jerold S Harmatz; Steven M Fogelman; Gengsheng Chen; Jennifer A Graf; Polyxane Mertzanis; Susan Byron; Kerry E Culm; Brian W Granda; Johanna Daily; Richard I Shader
Short-term exposure to low-dose ritonavir impairs clearance and enhances adverse effects of trazodone.
Journal of clinical pharmacology 2003;43(4):414-22.
2003: James L Weemhoff; Lisa L Von Moltke; Clemens Richert; Leah M Hesse; Jerold S Harmatz; David J Greenblatt
Apparent mechanism-based inhibition of human CYP3A in-vitro by lopinavir.
The Journal of pharmacy and pharmacology 2003;55(3):381-6.
2003: David J Greenblatt; Lisa L Von Moltke; Gina M Giancarlo; Daniel A Garteiz
Human cytochromes mediating gepirone biotransformation at low substrate concentrations.
Biopharmaceutics & drug disposition 2003;24(2):87-94.
2003: Kirk M Bertelsen; Karthik Venkatakrishnan; Lisa L Von Moltke; R Scott Obach; David J Greenblatt
Apparent mechanism-based inhibition of human CYP2D6 in vitro by paroxetine: comparison with fluoxetine and quinidine.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(3):289-93.
2003: Soundararajan Krishnaswamy; Su X Duan; Lisa L Von Moltke; David J Greenblatt; James L Sudmeier; William W Bachovchin; Michael H Court
Serotonin (5-hydroxytryptamine) glucuronidation in vitro: assay development, human liver microsome activities and species differences.
Xenobiotica; the fate of foreign compounds in biological systems 2003;33(2):169-80.
2003: Leah M Hesse; Lisa L Von Moltke; David J Greenblatt
Clinically important drug interactions with zopiclone, zolpidem and zaleplon.
CNS drugs 2003;17(7):513-32.
2003: Soundararajan Krishnaswamy; Su X Duan; Lisa L Von Moltke; David J Greenblatt; Michael H Court
Validation of serotonin (5-hydroxtryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(1):133-9.
2002: Lisa L Von Moltke; James L Weemhoff; Michael D Perloff; Leah M Hesse; Jerold S Harmatz; Barbara F Roth-Schechter; David J Greenblatt
Effect of zolpidem on human cytochrome P450 activity, and on transport mediated by P-glycoprotein.
Biopharmaceutics & drug disposition 2002;23(9):361-7.
2002: Thanh Huu Tran; Lisa L Von Moltke; Karthik Venkatakrishnan; Brian W Granda; Megan A Gibbs; R Scott Obach; Jerold S Harmatz; David J Greenblatt
Microsomal protein concentration modifies the apparent inhibitory potency of CYP3A inhibitors.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(12):1441-5.
2002: Michael D Perloff; Lisa L Von Moltke; David J Greenblatt
Fexofenadine transport in Caco-2 cells: inhibition with verapamil and ritonavir.
Journal of clinical pharmacology 2002;42(11):1269-74.
2002: Michael H Court; Su X Duan; Chantal Guillemette; Kim Journault; Soundararajan Krishnaswamy; Lisa L Von Moltke; David J Greenblatt
Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(11):1257-65.
2002: Joel O Olubodun; Hermann R Ochs; Volker Trüten; Arno Klein; Lisa L Von Moltke; Jerold S Harmatz; Richard I Shader; David J Greenblatt
Zolpidem pharmacokinetic properties in young females: influence of smoking and oral contraceptive use.
Journal of clinical pharmacology 2002;42(10):1142-6.
2002: Tsutomu Kotegawa; Bart E Laurijssens; Lisa L Von Moltke; Monette M Cotreau; Michael D Perloff; Karthik Venkatakrishnan; Jill S Warrington; Brian W Granda; Jerold S Harmatz; David J Greenblatt
In vitro, pharmacokinetic, and pharmacodynamic interactions of ketoconazole and midazolam in the rat.
The Journal of pharmacology and experimental therapeutics 2002;302(3):1228-37.
2002: Elke Störmer; Lisa L Von Moltke; Michael D Perloff; David J Greenblatt
Differential modulation of P-glycoprotein expression and activity by non-nucleoside HIV-1 reverse transcriptase inhibitors in cell culture.
Pharmaceutical research 2002;19(7):1038-45.
2002: Karthik Venkatakrishnan; Lisa L Von Moltke; David J Greenblatt
Evaluation of Supermix as an in vitro model of human liver microsomal drug metabolism.
Biopharmaceutics & drug disposition 2002;23(5):183-90.
2002: Jill S Warrington; Lisa L Von Moltke; Richard I Shader; David J Greenblatt
In vitro biotransformation of sildenafil (Viagra) in the male rat: the role of CYP2C11.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(6):655-7.
2002: Bart E Laurijssens; David J Greenblatt
Effect of 7-day exposure to midazolam on electroencephalogram pharmacodynamics in rats: a model to study multiple pharmacokinetic-pharmacodynamic relationships in individual animals.
The Journal of pharmacy and pharmacology 2002;54(1):77-86.
2001: Michael D Perloff; Lisa L Von Moltke; Elke Störmer; Richard I Shader; David J Greenblatt
Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure.
British journal of pharmacology 2001;134(8):1601-8.
2001: Michael D Perloff; Lisa L Von Moltke; J E Marchand; David J Greenblatt
Ritonavir induces P-glycoprotein expression, multidrug resistance-associated protein (MRP1) expression, and drug transporter-mediated activity in a human intestinal cell line.
Journal of pharmaceutical sciences 2001;90(11):1829-37.
2001: Karthik Venkatakrishnan; Lisa L Von Moltke; David J Greenblatt
Human drug metabolism and the cytochromes P450: application and relevance of in vitro models.
Journal of clinical pharmacology 2001;41(11):1149-79.
2001: Karthik Venkatakrishnan; J Schmider; Jerold S Harmatz; Bruce L Ehrenberg; Lisa L Von Moltke; Jennifer A Graf; Polyxane Mertzanis; Kathleen E Corbett; M C Rodriguez; Richard I Shader; David J Greenblatt
Relative contribution of CYP3A to amitriptyline clearance in humans: in vitro and in vivo studies.
Journal of clinical pharmacology 2001;41(10):1043-54.
2001: Lisa L Von Moltke; David J Greenblatt; M K Romach; E M Sellers
Cognitive toxicity of drugs used in the elderly.
Dialogues in clinical neuroscience 2001;3(3):181-90.
2001: Lisa L Von Moltke; David J Greenblatt; Gina M Giancarlo; Brian W Granda; Jerold S Harmatz; Richard I Shader
Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(8):1102-9.
2001: Elke Störmer; Lisa L Von Moltke; Michael D Perloff; David J Greenblatt
P-glycoprotein interactions of nefazodone and trazodone in cell culture.
Journal of clinical pharmacology 2001;41(7):708-14.
2001: Elke Störmer; Michael D Perloff; Lisa L Von Moltke; David J Greenblatt
Methadone inhibits rhodamine123 transport in Caco-2 cells.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(7):954-6.
2001: Jeanne M Fahey; Gary A Pritchard; Jeffrey M Grassi; John Pratt; Richard I Shader; David J Greenblatt
Pharmacodynamic and receptor binding changes during chronic lorazepam administration.
Pharmacology, biochemistry, and behavior 2001;69(1-2):1-8.
2001: Gina M Giancarlo; Karthik Venkatakrishnan; Brian W Granda; Lisa L Von Moltke; David J Greenblatt
Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: inhibition by sulfaphenazole, omeprazole, and ticlopidine.
European journal of clinical pharmacology 2001;57(1):31-6.
2001: Karthik Venkatakrishnan; Lisa L Von Moltke; David J Greenblatt
Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate.
The Journal of pharmacology and experimental therapeutics 2001;297(1):326-37.
2001: Leah M Hesse; Karthik Venkatakrishnan; Lisa L Von Moltke; Richard I Shader; David J Greenblatt
CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(2):133-40.
2001: Leah M Hesse; Lisa L Von Moltke; Richard I Shader; David J Greenblatt
Ritonavir, efavirenz, and nelfinavir inhibit CYP2B6 activity in vitro: potential drug interactions with bupropion.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(2):100-2.
2001: Monette M Cotreau; Lisa L Von Moltke; Jerold S Harmatz; David J Greenblatt
Molecular and pharmacokinetic evaluation of rat hepatic and gastrointestinal cytochrome p450 induction by tamoxifen.
Pharmacology 2001;63(4):210-9.
2001: Lisa L Von Moltke; David J Greenblatt; Brian W Granda; Gina M Giancarlo; Su X Duan; Johanna Daily; Jerold S Harmatz; Richard I Shader
Inhibition of human cytochrome P450 isoforms by nonnucleoside reverse transcriptase inhibitors.
Journal of clinical pharmacology 2001;41(1):85-91.
2001: Michael H Court; Su X Duan; Leah M Hesse; Karthik Venkatakrishnan; David J Greenblatt
Cytochrome P-450 2B6 is responsible for interindividual variability of propofol hydroxylation by human liver microsomes.
Anesthesiology 2001;94(1):110-9.
2000: Karthik Venkatakrishnan; Lisa L Von Moltke; Michael H Court; Jerold S Harmatz; C L Crespi; David J Greenblatt
Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(12):1493-504.
2000: Elke Störmer; Lisa L Von Moltke; David J Greenblatt
Scaling drug biotransformation data from cDNA-expressed cytochrome P-450 to human liver: a comparison of relative activity factors and human liver abundance in studies of mirtazapine metabolism.
The Journal of pharmacology and experimental therapeutics 2000;295(2):793-801.
2000: Leah M Hesse; Karthik Venkatakrishnan; Michael H Court; Lisa L Von Moltke; Su X Duan; Richard I Shader; David J Greenblatt
CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(10):1176-83.
2000: Elke Störmer; Lisa L Von Moltke; Richard I Shader; David J Greenblatt
Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(10):1168-75.
2000: David J Greenblatt; Lisa L Von Moltke; Bruce L Ehrenberg; Jerold S Harmatz; Kathleen E Corbett; D W Wallace; Richard I Shader
Kinetics and dynamics of lorazepam during and after continuous intravenous infusion.
Critical care medicine 2000;28(8):2750-7.
2000: Michael D Perloff; Lisa L Von Moltke; Jeanne M Fahey; Johanna Daily; David J Greenblatt
Induction of P-glycoprotein expression by HIV protease inhibitors in cell culture.
AIDS (London, England) 2000;14(9):1287-9.
2000: Lisa L Von Moltke; AL Durol; Su X Duan; David J Greenblatt
Potent mechanism-based inhibition of human CYP3A in vitro by amprenavir and ritonavir: comparison with ketoconazole.
European journal of clinical pharmacology 2000;56(3):259-61.
2000: David J Greenblatt; Lisa L Von Moltke; Jerold S Harmatz; AL Durol; Johanna Daily; Jennifer A Graf; Polyxane Mertzanis; J L Hoffman; Richard I Shader
Differential impairment of triazolam and zolpidem clearance by ritonavir.
Journal of acquired immune deficiency syndromes (1999) 2000;24(2):129-36.
2000: Michael H Court; David J Greenblatt
Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms.
Pharmacogenetics 2000;10(4):355-69.
2000: Gary B Kaplan; David J Greenblatt; Bruce L Ehrenberg; JE Goddard; Jerold S Harmatz; Richard I Shader
Differences in pharmacodynamics but not pharmacokinetics between subjects with panic disorder and healthy subjects after treatment with a single dose of alprazolam.
Journal of clinical psychopharmacology 2000;20(3):338-46.
2000: David J Greenblatt; Jerold S Harmatz; Lisa L Von Moltke; C Eugene Wright; AL Durol; L M Harrel-Joseph; Richard I Shader
Comparative kinetics and response to the benzodiazepine agonists triazolam and zolpidem: evaluation of sex-dependent differences.
The Journal of pharmacology and experimental therapeutics 2000;293(2):435-43.
2000: Karthik Venkatakrishnan; Lisa L Von Moltke; R Scott Obach; David J Greenblatt
Microsomal binding of amitriptyline: effect on estimation of enzyme kinetic parameters in vitro.
The Journal of pharmacology and experimental therapeutics 2000;293(2):343-50.
2000: David J Greenblatt; Lisa L Von Moltke; Jerold S Harmatz; AL Durol; Johanna Daily; Jennifer A Graf; Polyxane Mertzanis; J L Hoffman; Richard I Shader
Alprazolam-ritonavir interaction: implications for product labeling.
Clinical pharmacology and therapeutics 2000;67(4):335-41.
2000: A Zalma; Lisa L Von Moltke; Brian W Granda; Jerold S Harmatz; Richard I Shader; David J Greenblatt
In vitro metabolism of trazodone by CYP3A: inhibition by ketoconazole and human immunodeficiency viral protease inhibitors.
Biological psychiatry 2000;47(7):655-61.
2000: Jill S Warrington; Richard I Shader; Lisa L Von Moltke; David J Greenblatt
In vitro biotransformation of sildenafil (Viagra): identification of human cytochromes and potential drug interactions.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(4):392-7.
2000: J S Warrington; J W Poku; Lisa L Von Moltke; Richard I Shader; Jerold S Harmatz; David J Greenblatt
Effects of age on in vitro midazolam biotransformation in male CD-1 mouse liver microsomes.
The Journal of pharmacology and experimental therapeutics 2000;292(3):1024-31.
2000: Karthik Venkatakrishnan; Lisa L Von Moltke; David J Greenblatt
Effects of the antifungal agents on oxidative drug metabolism: clinical relevance.
Clinical pharmacokinetics 2000;38(2):111-80.
2000: Lisa L Von Moltke; T H Tran; Monette M Cotreau; David J Greenblatt
Unusually low clearance of two CYP3A substrates, alprazolam and trazodone, in a volunteer subject with wild-type CYP3A4 promoter region.
Journal of clinical pharmacology 2000;40(2):200-4.
2000: Michael D Perloff; Lisa L Von Moltke; M H Court; Tsutomu Kotegawa; Richard I Shader; David J Greenblatt
Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms.
The Journal of pharmacology and experimental therapeutics 2000;292(2):618-28.
2000: Monette M Cotreau; Lisa L Von Moltke; M C Beinfeld; David J Greenblatt
Methodologies to study the induction of rat hepatic and intestinal cytochrome P450 3A at the mRNA, protein, and catalytic activity level.
Journal of pharmacological and toxicological methods 2000;43(1):41-54.
1999: Karthik Venkatakrishnan; Lisa L Von Moltke; David J Greenblatt
CYP2C9 is a principal low-affinity phenacetin O-deethylase: fluvoxamine is not a specific CYP1A2 inhibitor.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(12):1519-22.
1999: Richard I Shader; Brian W Granda; Lisa L Von Moltke; Gina M Giancarlo; David J Greenblatt
Inhibition of human cytochrome P450 isoforms in vitro by zafirlukast.
Biopharmaceutics & drug disposition 1999;20(8):385-8.
1999: Michael H Court; B L Hay-Kraus; Dennis W Hill; AJ Kind; David J Greenblatt
Propofol hydroxylation by dog liver microsomes: assay development and dog breed differences.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(11):1293-9.
1999: David J Greenblatt; Lisa L Von Moltke; Jerold S Harmatz; Richard I Shader
Human cytochromes and some newer antidepressants: kinetics, metabolism, and drug interactions.
Journal of clinical psychopharmacology 1999;19(5 Suppl 1):23S-35S.
1999: Lisa L Von Moltke; David J Greenblatt; Jeffrey M Grassi; Brian W Granda; Karthik Venkatakrishnan; Su X Duan; Steven M Fogelman; Jerold S Harmatz; Richard I Shader
Citalopram and desmethylcitalopram in vitro: human cytochromes mediating transformation, and cytochrome inhibitory effects.
Biological psychiatry 1999;46(6):839-49.
1999: Richard I Shader; Jerold S Harmatz; Jessica R Oesterheld; D X Parmelee; F R Sallee; David J Greenblatt
Population pharmacokinetics of methylphenidate in children with attention-deficit hyperactivity disorder.
Journal of clinical pharmacology 1999;39(8):775-85.
1999: Lisa L Von Moltke; David J Greenblatt; Brian W Granda; Jeffrey M Grassi; J Schmider; Jerold S Harmatz; Richard I Shader
Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions.
Psychopharmacology 1999;145(1):113-22.
1999: Lisa L Von Moltke; David J Greenblatt; Brian W Granda; Su X Duan; Jeffrey M Grassi; Karthik Venkatakrishnan; Jerold S Harmatz; Richard I Shader
Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations.
British journal of clinical pharmacology 1999;48(1):89-97.
1999: Karthik Venkatakrishnan; Lisa L Von Moltke; David J Greenblatt
Nortriptyline E-10-hydroxylation in vitro is mediated by human CYP2D6 (high affinity) and CYP3A4 (low affinity): implications for interactions with enzyme-inducing drugs.
Journal of clinical pharmacology 1999;39(6):567-77.
1999: Michael D Perloff; Lisa L Von Moltke; Monette M Cotreau; David J Greenblatt
Unchanged cytochrome P450 3A (CYP3A) expression and metabolism of midazolam, triazolam, and dexamethasone in mdr(-/-) mouse liver microsomes.
Biochemical pharmacology 1999;57(11):1227-32.
1999: J Schmider; Lisa L Von Moltke; Richard I Shader; Jerold S Harmatz; David J Greenblatt
Extrapolating in vitro data on drug metabolism to in vivo pharmacokinetics: evaluation of the pharmacokinetic interaction between amitriptyline and fluoxetine.
Drug metabolism reviews 1999;31(2):545-60.
1999: Steven M Fogelman; J Schmider; Karthik Venkatakrishnan; Lisa L Von Moltke; Jerold S Harmatz; Richard I Shader; David J Greenblatt
O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1999;20(5):480-90.
1999: Jeanne M Fahey; Gary A Pritchard; Jeffrey M Grassi; John Pratt; Richard I Shader; David J Greenblatt
In situ hybridization histochemistry as a method to assess GABA(A) receptor subunit mRNA expression following chronic alprazolam administration.
Journal of psychopharmacology (Oxford, England) 1999;13(3):211-8.
1999: Tsutomu Kotegawa; Bart E Laurijssens; AL Durol; David J Greenblatt
Pharmacokinetics and electroencephalographic effects of ketoconazole in the rat.
Biopharmaceutics & drug disposition 1999;20(1):49-52.
1999: Jeanne M Fahey; Gary A Pritchard; John Pratt; Richard I Shader; David J Greenblatt
Lorazepam attenuates the behavioral effects of dizocilpine.
Pharmacology, biochemistry, and behavior 1999;62(1):103-10.
1998: Karthik Venkatakrishnan; Lisa L Von Moltke; David J Greenblatt
Human cytochromes P450 mediating phenacetin O-deethylation in vitro: validation of the high affinity component as an index of CYP1A2 activity.
Journal of pharmaceutical sciences 1998;87(12):1502-7.
1998: Lisa L Von Moltke; David J Greenblatt; Jeffrey M Grassi; Brian W Granda; Steven M Fogelman; Jerold S Harmatz; S J Kramer; L F Fabre; Richard I Shader
Gepirone and 1-(2-pyrimidinyl)-piperazine in vitro: human cytochromes mediating transformation and cytochrome inhibitory effects.
Psychopharmacology 1998;140(3):293-9.
1998: David J Greenblatt; Lisa L Von Moltke; Jerold S Harmatz; Polyxane Mertzanis; Jennifer A Graf; AL Durol; M Counihan; B Roth-Schechter; Richard I Shader
Kinetic and dynamic interaction study of zolpidem with ketoconazole, itraconazole, and fluconazole.
Clinical pharmacology and therapeutics 1998;64(6):661-71.
1998: Brian W Granda; Gina M Giancarlo; Lisa L Von Moltke; David J Greenblatt
Analysis of ritonavir in plasma/serum and tissues by high-performance liquid chromatography.
Journal of pharmacological and toxicological methods 1998;40(4):235-9.
1998: David J Greenblatt; Jerold S Harmatz; Lisa L Von Moltke; Bruce L Ehrenberg; L Harrel; Kathleen E Corbett; M Counihan; Jennifer A Graf; Mona Darwish; Polyxane Mertzanis; PT Martin; WH Cevallos; Richard I Shader
Comparative kinetics and dynamics of zaleplon, zolpidem, and placebo.
Clinical pharmacology and therapeutics 1998;64(5):553-61.
1998: Lisa L Von Moltke; David J Greenblatt; Su X Duan; Johanna Daily; Jerold S Harmatz; Richard I Shader
Inhibition of desipramine hydroxylation (Cytochrome P450-2D6) in vitro by quinidine and by viral protease inhibitors: relation to drug interactions in vivo.
Journal of pharmaceutical sciences 1998;87(10):1184-9.
1998: Lisa L Von Moltke; David J Greenblatt; Jeffrey M Grassi; Brian W Granda; Karthik Venkatakrishnan; J Schmider; Jerold S Harmatz; Richard I Shader
Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: role of CYP2C9, CYP2C19, CYP2D6, and CYP3A.
The Journal of pharmacy and pharmacology 1998;50(9):997-1004.
1998: David J Greenblatt; Lisa L Von Moltke; Jerold S Harmatz; M Counihan; Jennifer A Graf; AL Durol; Polyxane Mertzanis; Su X Duan; C Eugene Wright; Richard I Shader
Inhibition of triazolam clearance by macrolide antimicrobial agents: in vitro correlates and dynamic consequences.
Clinical pharmacology and therapeutics 1998;64(3):278-85.
1998: David J Greenblatt; C Eugene Wright; Lisa L Von Moltke; Jerold S Harmatz; Bruce L Ehrenberg; L M Harrel; Kathleen E Corbett; M Counihan; S Tobias; Richard I Shader
Ketoconazole inhibition of triazolam and alprazolam clearance: differential kinetic and dynamic consequences.
Clinical pharmacology and therapeutics 1998;64(3):237-47.
1998: Lisa L Von Moltke; David J Greenblatt; D A Ciraulo; Jeffrey M Grassi; Brian W Granda; Su X Duan; Jerold S Harmatz; Richard I Shader
Appetite suppressant drugs as inhibitors of human cytochromes P450: in vitro inhibition of P450-2D6 by D- and L-fenfluramine, but not phentermine.
Journal of clinical psychopharmacology 1998;18(4):338-41.
1998: Richard I Shader; Steven M Fogelman; David J Greenblatt
Epiphenomenal, causal, or correlational--more on the mechanism(s) of action of antidepressants.
Journal of clinical psychopharmacology 1998;18(4):265-7.
1998: Joseph M Scavone; David J Greenblatt; Jerold S Harmatz; N Engelhardt; Richard I Shader
Pharmacokinetics and pharmacodynamics of diphenhydramine 25 mg in young and elderly volunteers.
Journal of clinical pharmacology 1998;38(7):603-9.
1998: David J Greenblatt
The maturation of clinical pharmacology: recognizing the contributions of Dr. Louis Lasagna.
Journal of clinical pharmacology 1998;38(7):572-4.
1998: Karthik Venkatakrishnan; Lisa L Von Moltke; David J Greenblatt
Relative quantities of catalytically active CYP 2C9 and 2C19 in human liver microsomes: application of the relative activity factor approach.
Journal of pharmaceutical sciences 1998;87(7):845-53.
1998: Karthik Venkatakrishnan; David J Greenblatt; Lisa L Von Moltke; Richard I Shader
Alprazolam is another substrate for human cytochrome P450-3A isoforms.
Journal of clinical psychopharmacology 1998;18(3):256.
1998: Jeanne M Fahey; Gary A Pritchard; L L Moltke; John Pratt; Jeffrey M Grassi; Richard I Shader; David J Greenblatt
Effects of ketoconazole on triazolam pharmacokinetics, pharmacodynamics and benzodiazepine receptor binding in mice.
The Journal of pharmacology and experimental therapeutics 1998;285(1):271-6.
1998: Karthik Venkatakrishnan; Lisa L Von Moltke; Su X Duan; Joseph C Fleishaker; Richard I Shader; David J Greenblatt
Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man.
The Journal of pharmacy and pharmacology 1998;50(3):265-74.
1998: Karthik Venkatakrishnan; David J Greenblatt; Lisa L Von Moltke; J Schmider; Jerold S Harmatz; Richard I Shader
Five distinct human cytochromes mediate amitriptyline N-demethylation in vitro: dominance of CYP 2C19 and 3A4.
Journal of clinical pharmacology 1998;38(2):112-21.
1998: Lisa L Von Moltke; David J Greenblatt; Jeffrey M Grassi; Brian W Granda; Su X Duan; Steven M Fogelman; Johanna Daily; Jerold S Harmatz; Richard I Shader
Protease inhibitors as inhibitors of human cytochromes P450: high risk associated with ritonavir.
Journal of clinical pharmacology 1998;38(2):106-11.
1998: Lisa L Von Moltke; David J Greenblatt; J Schmider; C Eugene Wright; Jerold S Harmatz; Richard I Shader
In vitro approaches to predicting drug interactions in vivo.
Biochemical pharmacology 1998;55(2):113-22.
1998: David J Greenblatt; Lisa L Von Moltke; Jerold S Harmatz; Richard I Shader
Drug interactions with newer antidepressants: role of human cytochromes P450.
The Journal of clinical psychiatry 1998;59 Suppl 15():19-27.
1998: Gary B Kaplan; David J Greenblatt; Bruce L Ehrenberg; JE Goddard; Jerold S Harmatz; Richard I Shader
Single-dose pharmacokinetics and pharmacodynamics of alprazolam in elderly and young subjects.
Journal of clinical pharmacology 1998;38(1):14-21.
1997: J M Koff; Gary A Pritchard; David J Greenblatt; L G Miller
The NMDA receptor competitive antagonist CPP modulates benzodiazepine tolerance and discontinuation.
Pharmacology 1997;55(5):217-27.
1997: J Schmider; David J Greenblatt; Lisa L Von Moltke; D Karsov; Richard I Shader
Inhibition of CYP2C9 by selective serotonin reuptake inhibitors in vitro: studies of phenytoin p-hydroxylation.
British journal of clinical pharmacology 1997;44(5):495-8.
1997: AL Durol; David J Greenblatt
Analysis of zolpidem in human plasma by high-performance liquid chromatography with fluorescence detection: application to single-dose pharmacokinetic studies.
Journal of analytical toxicology 1997;21(5):388-92.
1997: Gary B Kaplan; David J Greenblatt; Bruce L Ehrenberg; JE Goddard; Monette M Cotreau; Jerold S Harmatz; Richard I Shader
Dose-dependent pharmacokinetics and psychomotor effects of caffeine in humans.
Journal of clinical pharmacology 1997;37(8):693-703.
1997: Lisa L Von Moltke; David J Greenblatt; Su X Duan; J Schmider; C Eugene Wright; Jerold S Harmatz; Richard I Shader
Human cytochromes mediating N-demethylation of fluoxetine in vitro.
Psychopharmacology 1997;132(4):402-7.
1997: Joseph M Scavone; David J Greenblatt; Darrell R. Abernethy; B G Luna; Jerold S Harmatz; Richard I Shader
Influence of oral contraceptive use and cigarette smoking, alone and together, on antipyrine pharmacokinetics.
Journal of clinical pharmacology 1997;37(5):437-41.
1997: Michael H Court; David J Greenblatt
Molecular basis for deficient acetaminophen glucuronidation in cats. An interspecies comparison of enzyme kinetics in liver microsomes.
Biochemical pharmacology 1997;53(7):1041-7.
1997: Richard I Shader; Steven M Fogelman; David J Greenblatt
Newer antidepressants: further reflections.
Journal of clinical psychopharmacology 1997;17(2):75-7.
1997: Michael H Court; David J Greenblatt
Biochemical basis for deficient paracetamol glucuronidation in cats: an interspecies comparison of enzyme constraint in liver microsomes.
The Journal of pharmacy and pharmacology 1997;49(4):446-9.
1997: J Schmider; David J Greenblatt; Steven M Fogelman; Lisa L Von Moltke; Richard I Shader
Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1.
Biopharmaceutics & drug disposition 1997;18(3):227-40.
1997: Michael H Court; Lisa L Von Moltke; Richard I Shader; David J Greenblatt
Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species.
Biopharmaceutics & drug disposition 1997;18(3):213-26.
1997: K P Charpentier; Lisa L Von Moltke; J W Poku; Jerold S Harmatz; Richard I Shader; David J Greenblatt
Alprazolam hydroxylation by mouse liver microsomes in vitro: the effect of age and phenobarbital induction.
Biopharmaceutics & drug disposition 1997;18(2):139-49.
1997: J Schmider; David J Greenblatt; Lisa L Von Moltke; D Karsov; R Vena; H L Friedman; Richard I Shader
Biotransformation of mestranol to ethinyl estradiol in vitro: the role of cytochrome P-450 2C9 and metabolic inhibitors.
Journal of clinical pharmacology 1997;37(3):193-200.
1997: Lisa L Von Moltke; Su X Duan; David J Greenblatt; Steven M Fogelman; J Schmider; Jerold S Harmatz; Richard I Shader
Venlafaxine and metabolites are very weak inhibitors of human cytochrome P450-3A isoforms.
Biological psychiatry 1997;41(3):377-80.
1997: Richard I Shader; Steven M Fogelman; David J Greenblatt
Newer antidepressants: hypotheses and evidence.
Journal of clinical psychopharmacology 1997;17(1):1-3.
1996: Lisa L Von Moltke; David J Greenblatt; Su X Duan; J Schmider; L Kudchadker; Steven M Fogelman; Jerold S Harmatz; Richard I Shader
Phenacetin O-deethylation by human liver microsomes in vitro: inhibition by chemical probes, SSRI antidepressants, nefazodone and venlafaxine.
Psychopharmacology 1996;128(4):398-407.
1996: M M Cotreau-Bibbo; Lisa L Von Moltke; David J Greenblatt
Influence of polyethylene glycol and acetone on the in vitro biotransformation of tamoxifen and alprazolam by human liver microsomes.
Journal of pharmaceutical sciences 1996;85(11):1180-5.
1996: David J Greenblatt; Lisa L Von Moltke; J Schmider; Jerold S Harmatz; Richard I Shader
Inhibition of human cytochrome P450-3A isoforms by fluoxetine and norfluoxetine: in vitro and in vivo studies.
Journal of clinical pharmacology 1996;36(9):792-8.
1996: Lisa L Von Moltke; David J Greenblatt; J Schmider; Su X Duan; C Eugene Wright; Jerold S Harmatz; Richard I Shader
Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents.
Journal of clinical pharmacology 1996;36(9):783-91.
1996: Domenic A Ciraulo; O Sarid-Segal; C Knapp; Ann Marie Ciraulo; David J Greenblatt; Richard I Shader
Liability to alprazolam abuse in daughters of alcoholics.
The American journal of psychiatry 1996;153(7):956-8.
1996: J Schmider; David J Greenblatt; Jerold S Harmatz; Richard I Shader
Enzyme kinetic modelling as a tool to analyse the behaviour of cytochrome P450 catalysed reactions: application to amitriptyline N-demethylation.
British journal of clinical pharmacology 1996;41(6):593-604.
1996: J Schmider; David J Greenblatt; Lisa L Von Moltke; Jerold S Harmatz; Richard I Shader
Inhibition of cytochrome P450 by nefazodone in vitro: studies of dextromethorphan O- and N-demethylation.
British journal of clinical pharmacology 1996;41(4):339-43.
1996: Lisa L Von Moltke; David J Greenblatt; Su X Duan; Jerold S Harmatz; C Eugene Wright; Richard I Shader
Inhibition of terfenadine metabolism in vitro by azole antifungal agents and by selective serotonin reuptake inhibitor antidepressants: relation to pharmacokinetic interactions in vivo.
Journal of clinical psychopharmacology 1996;16(2):104-12.
1996: J Schmider; David J Greenblatt; Lisa L Von Moltke; Jerold S Harmatz; Su X Duan; D Karsov; Richard I Shader
Characterization of six in vitro reactions mediated by human cytochrome P450: application to the testing of cytochrome P450-directed antibodies.
Pharmacology 1996;52(2):125-34.
1996: Lisa L Von Moltke; David J Greenblatt; Jerold S Harmatz; Su X Duan; L M Harrel; M M Cotreau-Bibbo; Gary A Pritchard; C Eugene Wright; Richard I Shader
Triazolam biotransformation by human liver microsomes in vitro: effects of metabolic inhibitors and clinical confirmation of a predicted interaction with ketoconazole.
The Journal of pharmacology and experimental therapeutics 1996;276(2):370-9.
1996: B E Laurijssens; David J Greenblatt
Pharmacokinetic-pharmacodynamic relationships for benzodiazepines.
Clinical pharmacokinetics 1996;30(1):52-76.
1995: J Schmider; David J Greenblatt; Lisa L Von Moltke; Jerold S Harmatz; Richard I Shader
N-demethylation of amitriptyline in vitro: role of cytochrome P-450 3A (CYP3A) isoforms and effect of metabolic inhibitors.
The Journal of pharmacology and experimental therapeutics 1995;275(2):592-7.
1995: Lisa L Von Moltke; David J Greenblatt; Michael H Court; Su X Duan; Jerold S Harmatz; Richard I Shader
Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine: comparison with other selective serotonin reuptake inhibitor antidepressants.
Journal of clinical psychopharmacology 1995;15(2):125-31.
1995: David J Greenblatt
The pharmacology of benzodiazepines: comments on terminology and sources of data.
Psychopharmacology 1995;118(2):119; discussion 120-1.
1995: David J Greenblatt; Lisa L Von Moltke; Jerold S Harmatz; L M Harrel; S Tobias; Richard I Shader; C Eugene Wright
Interaction of triazolam and ketoconazole.
Lancet 1995;345(8943):191.
1995: Lisa L Von Moltke; David J Greenblatt; J Schmider; Jerold S Harmatz; Richard I Shader
Metabolism of drugs by cytochrome P450 3A isoforms. Implications for drug interactions in psychopharmacology.
Clinical pharmacokinetics 1995;29 Suppl 1():33-43; discussion 43-4.
1994: Lisa L Von Moltke; David J Greenblatt; Su X Duan; Jerold S Harmatz; Richard I Shader
In vitro prediction of the terfenadine-ketoconazole pharmacokinetic interaction.
Journal of clinical pharmacology 1994;34(12):1222-7.
1994: David J Greenblatt; Jerold S Harmatz; T A Gouthro; J Locke; Richard I Shader
Distinguishing a benzodiazepine agonist (triazolam) from a nonagonist anxiolytic (buspirone) by electroencephalography: kinetic-dynamic studies.
Clinical pharmacology and therapeutics 1994;56(1):100-11.
1994: Lisa L Von Moltke; David J Greenblatt; M M Cotreau-Bibbo; Jerold S Harmatz; Richard I Shader
Inhibitors of alprazolam metabolism in vitro: effect of serotonin-reuptake-inhibitor antidepressants, ketoconazole and quinidine.
British journal of clinical pharmacology 1994;38(1):23-31.
1994: Lisa L Von Moltke; David J Greenblatt; M M Cotreau-Bibbo; Su X Duan; Jerold S Harmatz; Richard I Shader
Inhibition of desipramine hydroxylation in vitro by serotonin-reuptake-inhibitor antidepressants, and by quinidine and ketoconazole: a model system to predict drug interactions in vivo.
The Journal of pharmacology and experimental therapeutics 1994;268(3):1278-83.
1993: Jeremiah F Kelly; David J Greenblatt
Rapid and sensitive gas chromatographic determination of estazolam.
Journal of chromatography 1993;621(1):102-4.
1993: Lisa L Von Moltke; David J Greenblatt; Jerold S Harmatz; Richard I Shader
Alprazolam metabolism in vitro: studies of human, monkey, mouse, and rat liver microsomes.
Pharmacology 1993;47(4):268-76.
1993: David J Greenblatt
Basic pharmacokinetic principles and their application to psychotropic drugs.
The Journal of clinical psychiatry 1993;54 Suppl():8-13; discussion 55-6.
1993: Gary B Kaplan; David J Greenblatt; M A Kent; M M Cotreau-Bibbo
Caffeine treatment and withdrawal in mice: relationships between dosage, concentrations, locomotor activity and A1 adenosine receptor binding.
The Journal of pharmacology and experimental therapeutics 1993;266(3):1563-72.
1993: David J Greenblatt; Jerold S Harmatz; Richard I Shader
Plasma alprazolam concentrations. Relation to efficacy and side effects in the treatment of panic disorder.
Archives of general psychiatry 1993;50(9):715-22.
1993: David J Greenblatt
Presystemic extraction: mechanisms and consequences.
Journal of clinical pharmacology 1993;33(7):650-6.
1993: David J Greenblatt; C Eugene Wright
Clinical pharmacokinetics of alprazolam. Therapeutic implications.
Clinical pharmacokinetics 1993;24(6):453-71.
1993: Richard I Shader; David J Greenblatt
Use of benzodiazepines in anxiety disorders.
The New England journal of medicine 1993;328(19):1398-405.
1993: John J Byrnes; L G Miller; K Perkins; David J Greenblatt; Richard I Shader
Chronic benzodiazepine administration. XI. Concurrent administration of PK11195 attenuates lorazepam discontinuation effects.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1993;8(3):267-73.
1993: David J Greenblatt; J M Scavone; Jerold S Harmatz; N Engelhardt; Richard I Shader
Cognitive effects of beta-adrenergic antagonists after single doses: pharmacokinetics and pharmacodynamics of propranolol, atenolol, lorazepam, and placebo.
Clinical pharmacology and therapeutics 1993;53(5):577-84.
1993: L L von Moltke; M Manis; J S Harmatz; R Poorman; David J Greenblatt
Inhibition of acetaminophen and lorazepam glucuronidation in vitro by probenecid.
Biopharmaceutics & drug disposition 1993;14(2):119-30.
1993: Lisa L Von Moltke; David J Greenblatt; Richard I Shader
Clinical pharmacokinetics of antidepressants in the elderly. Therapeutic implications.
Clinical pharmacokinetics 1993;24(2):141-60.
1993: John J Byrnes; L G Miller; David J Greenblatt; Richard I Shader
Chronic benzodiazepine administration. XII. Anticonvulsant cross-tolerance but distinct neurochemical effects of alprazolam and lorazepam.
Psychopharmacology 1993;111(1):91-5.
1992: John J Byrnes; David J Greenblatt; L G Miller
Benzodiazepine receptor binding of nonbenzodiazepines in vivo: alpidem, zolpidem and zopiclone.
Brain research bulletin 1992;29(6):905-8.
1992: David J Greenblatt; S H Preskorn; M M Cotreau; W D Horst; Jerold S Harmatz
Fluoxetine impairs clearance of alprazolam but not of clonazepam.
Clinical pharmacology and therapeutics 1992;52(5):479-86.
1992: L G Miller; M L Thompson; John J Byrnes; David J Greenblatt; A Shemer
Kinetics, brain uptake, and receptor binding of tandospirone and its metabolite 1-(2-pyrimidinyl)-piperazine.
Journal of clinical psychopharmacology 1992;12(5):341-5.
1992: L G Miller; W R Galpern; John J Byrnes; David J Greenblatt
Benzodiazepine receptor binding of benzodiazepine hypnotics: receptor and ligand specificity.
Pharmacology, biochemistry, and behavior 1992;43(2):413-6.
1992: Gary B Kaplan; M M Cotreau; David J Greenblatt
Effects of benzodiazepine administration on A1 adenosine receptor binding in-vivo and ex-vivo.
The Journal of pharmacy and pharmacology 1992;44(8):700-3.
1992: David J Greenblatt
Pharmacology of benzodiazepine hypnotics.
The Journal of clinical psychiatry 1992;53 Suppl():7-13.
1992: Gary B Kaplan; David J Greenblatt; M A Kent; M M Cotreau; G Arcelin; Richard I Shader
Caffeine-induced behavioral stimulation is dose-dependent and associated with A1 adenosine receptor occupancy.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1992;6(3):145-53.
1992: F Lopez; L G Miller; David J Greenblatt; A Schatzki; M Lumpkin; Richard I Shader
Chronic low-dose alprazolam augments gamma-aminobutyric acid(A) receptor function.
Journal of clinical psychopharmacology 1992;12(2):119-23.
1992: L G Miller; W R Galpern; John J Byrnes; David J Greenblatt; Richard I Shader
Chronic benzodiazepine administration. X. Concurrent administration of the peripheral-type benzodiazepine ligand PK11195 attenuates chronic effects of lorazepam.
The Journal of pharmacology and experimental therapeutics 1992;261(1):285-9.
1992: J M Scavone; David J Greenblatt; J E Goddard; H Friedman; J S Harmatz; Richard I Shader
The pharmacokinetics and pharmacodynamics of sublingual and oral alprazolam in the post-prandial state.
European journal of clinical pharmacology 1992;42(4):439-43.
1991: W R Galpern; L G Miller; David J Greenblatt; GK Szabo; TR Browne; Richard I Shader
Chronic benzodiazepine administration. IX. Attenuation of alprazolam discontinuation effects by carbamazepine.
Biochemical pharmacology 1991;42 Suppl():S99-104.
1991: David J Greenblatt; Jerold S Harmatz; Richard I Shader
Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (Part II).
Clinical pharmacokinetics 1991;21(4):262-73.
1991: L G Miller; S Chesley; W R Galpern; David J Greenblatt; Richard I Shader
Prenatal benzodiazepine administration. II. Lorazepam exposure is associated with decreases in [35S]TBPS binding but not benzodiazepine binding.
Pharmacology, biochemistry, and behavior 1991;40(2):429-32.
1991: Richard I Shader; David J Greenblatt; MB Balter
Appropriate use and regulatory control of benzodiazepines.
Journal of clinical pharmacology 1991;31(9):781-4.
1991: David J Greenblatt; Jerold S Harmatz; Richard I Shader
Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (Part I).
Clinical pharmacokinetics 1991;21(3):165-77.
1991: David J Greenblatt
Benzodiazepine hypnotics: sorting the pharmacokinetic facts.
The Journal of clinical psychiatry 1991;52 Suppl():4-10.
1991: David J Greenblatt
Introduction: pharmacokinetic considerations. Benzodiazepine hypnotics: the interface of basic and clinical science.
The Journal of clinical psychiatry 1991;52 Suppl():3.
1991: J G Barnhill; Domenic A Ciraulo; David J Greenblatt; M A Faggart; Jerold S Harmatz
Benzodiazepine response and receptor binding after chronic ethanol ingestion in a mouse model.
The Journal of pharmacology and experimental therapeutics 1991;258(3):812-9.
1991: J S Kennedy; L L von Moltke; Jerold S Harmatz; N Engelhardt; David J Greenblatt
Validity of self-reports of caffeine use.
Journal of clinical pharmacology 1991;31(7):677-80.
1991: David J Greenblatt; Jerold S Harmatz; L Shapiro; N Engelhardt; T A Gouthro; Richard I Shader
Sensitivity to triazolam in the elderly.
The New England journal of medicine 1991;324(24):1691-8.
1991: L G Miller; M Lumpkin; W R Galpern; David J Greenblatt; Richard I Shader
Modification of gamma-aminobutyric acidA receptor binding and function by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in vitro and in vivo: effects of aging.
Journal of neurochemistry 1991;56(4):1241-7.
1991: L G Miller; M Lumpkin; David J Greenblatt; R I Shader
Accelerated benzodiazepine receptor recovery after lorazepam discontinuation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991;5(1):93-7.
1991: W R Galpern; M Lumpkin; David J Greenblatt; Richard I Shader; L G Miller
Chronic benzodiazepine administration. VII. Behavioral tolerance and withdrawal and receptor alterations associated with clonazepam administration.
Psychopharmacology 1991;104(2):225-30.
1991: J G Barnhill; L G Miller; David J Greenblatt; M L Thompson; Domenic A Ciraulo; Richard I Shader
Benzodiazepine receptor binding response to acute and chronic stress is increased in aging animals.
Pharmacology 1991;42(4):181-7.
1991: S Chesley; M Lumpkin; A Schatzki; W R Galpern; David J Greenblatt; Richard I Shader; L G Miller
Prenatal exposure to benzodiazepine--I. Prenatal exposure to lorazepam in mice alters open-field activity and GABAA receptor function.
Neuropharmacology 1991;30(1):53-8.
1990: David J Greenblatt; J I Javaid; A Locniskar; Jerold S Harmatz; Richard I Shader
Gas chromatographic analysis of alprazolam in plasma: replicability, stability and specificity.
Journal of chromatography 1990;534():202-7.
1990: W R Galpern; L G Miller; David J Greenblatt; Richard I Shader
Differential effects of chronic lorazepam and alprazolam on benzodiazepine binding and GABAA-receptor function.
British journal of pharmacology 1990;101(4):839-42.
1990: S F Chesley; A D Schatzki; J DeUrrutia; David J Greenblatt; Richard I Shader; L G Miller
Cocaine augments peripheral benzodiazepine binding in humans.
The Journal of clinical psychiatry 1990;51(10):404-6.
1990: L G Miller; J Heller; M Lumpkin; C L Weill; David J Greenblatt; Richard I Shader
Augmentation of GABAA receptor function by chronic exposure to GABA-neutral and GABA-negative benzodiazepine ligands in cultured cortical neurons.
Biochemical pharmacology 1990;40(6):1337-44.
1990: L Labedzki; J M Scavone; H R Ochs; David J Greenblatt
Reduced systemic absorption of intrabronchial lidocaine by high-frequency nebulization.
Journal of clinical pharmacology 1990;30(9):795-7.
1990: A Locniskar; David J Greenblatt
Oxidative versus conjugative biotransformation of temazepam.
Biopharmaceutics & drug disposition 1990;11(6):499-506.
1990: Gary B Kaplan; N T Tai; David J Greenblatt; Richard I Shader
Caffeine-induced behavioural stimulation is dose- and concentration-dependent.
British journal of pharmacology 1990;100(3):435-40.
1990: L G Miller; W R Galpern; David J Greenblatt; M Lumpkin; Richard I Shader
Chronic benzodiazepine administration. VI. A partial agonist produces behavioral effects without tolerance or receptor alterations.
The Journal of pharmacology and experimental therapeutics 1990;254(1):33-8.
1990: J G Barnhill; David J Greenblatt; L G Miller; A Gaver; Jerold S Harmatz; Richard I Shader
Kinetic and dynamic components of increased benzodiazepine sensitivity in aging animals.
The Journal of pharmacology and experimental therapeutics 1990;253(3):1153-61.
1990: David J Greenblatt
Pharmacokinetics and pharmacodynamics.
Hospital practice (Office ed.) 1990;25 Suppl 2():9-15; discussion 16-8.
1990: K A Lapierre; David J Greenblatt; J E Goddard; Jerold S Harmatz; Richard I Shader
The neuropsychiatric effects of aspartame in normal volunteers.
Journal of clinical pharmacology 1990;30(5):454-60.
1990: J M Scavone; B G Luna; Jerold S Harmatz; L von Moltke; David J Greenblatt
Diphenhydramine kinetics following intravenous, oral, and sublingual dimenhydrinate administration.
Biopharmaceutics & drug disposition 1990;11(3):185-9.
1990: F Lopez; L G Miller; David J Greenblatt; S Chesley; A Schatzki; Richard I Shader
Chronic administration of benzodiazepines--V. Rapid onset of behavioral and neurochemical alterations after discontinuation of alprazolam.
Neuropharmacology 1990;29(3):237-41.
1990: Domenic A Ciraulo; E J Antal; R B Smith; D R Olson; D A Goldberg; E H Rand; R B Raskin; J P Phillips; Richard I Shader; David J Greenblatt
The relationship of alprazolam dose to steady-state plasma concentrations.
Journal of clinical psychopharmacology 1990;10(1):27-32.
1990: J M Scavone; David J Greenblatt; B W LeDuc; G T Blyden; B G Luna; Jerold S Harmatz
Differential effect of cigarette smoking on antipyrine oxidation versus acetaminophen conjugation.
Pharmacology 1990;40(2):77-84.
1990: J M Scavone; David J Greenblatt; G T Blyden; B G Luna; Jerold S Harmatz
Validity of a two-point acetaminophen pharmacokinetic study.
Therapeutic drug monitoring 1990;12(1):35-9.
1990: Gary B Kaplan; N T Tai; David J Greenblatt; Richard I Shader
Separate and combined effects of caffeine and alprazolam on motor activity and benzodiazepine receptor binding in vivo.
Psychopharmacology 1990;101(4):539-44.
1990: J M Scavone; David J Greenblatt; G T Blyden; B G Luna; Jerold S Harmatz
Acetaminophen pharmacokinetics in women receiving conjugated estrogen.
European journal of clinical pharmacology 1990;38(1):97-8.
1990: L G Miller; David J Greenblatt; F Lopez; A Schatzki; J Heller; M Lumpkin; Richard I Shader
Chronic benzodiazepine administration: effects in vivo and in vitro.
Advances in biochemical psychopharmacology 1990;46():167-75.
1990: David J Greenblatt; L G Miller; R I Shader
Benzodiazepine discontinuation syndromes.
Journal of psychiatric research 1990;24 Suppl 2():73-9.
1990: David J Greenblatt; V H Sethy
Benzodiazepine concentrations in brain directly reflect receptor occupancy: studies of diazepam, lorazepam, and oxazepam.
Psychopharmacology 1990;102(3):373-8.
1990: F Lopez; L G Miller; M L Thompson; A Schatzki; S Chesley; David J Greenblatt; Richard I Shader
Chronic morphine administration augments benzodiazepine binding and GABAA receptor function.
Psychopharmacology 1990;101(4):545-9.
1989: J M Scavone; David J Greenblatt; D G Fraser
The bioavailability of intranasal lignocaine.
British journal of clinical pharmacology 1989;28(6):722-4.
1989: A Locniskar; David J Greenblatt; Jerold S Harmatz; Richard I Shader
Bioinequivalence of a generic brand of diazepam.
Biopharmaceutics & drug disposition 1989;10(6):597-605.
1989: David J Greenblatt; Jerold S Harmatz; H Friedman; A Locniskar; Richard I Shader
A large-sample study of diazepam pharmacokinetics.
Therapeutic drug monitoring 1989;11(6):652-7.
1989: Domenic A Ciraulo; J G Barnhill; Ann Marie Ciraulo; David J Greenblatt; Richard I Shader
Parental alcoholism as a risk factor in benzodiazepine abuse: a pilot study.
The American journal of psychiatry 1989;146(10):1333-5.
1989: David J Greenblatt; Richard I Shader; Jerold S Harmatz
Implications of altered drug disposition in the elderly: studies of benzodiazepines.
Journal of clinical pharmacology 1989;29(10):866-72.
1989: A Schatzki; F Lopez; David J Greenblatt; Richard I Shader; L G Miller
Lorazepam discontinuation promotes 'inverse agonist' effects of benzodiazepines.
British journal of pharmacology 1989;98(2):451-4.
1989: David J Greenblatt; Jerold S Harmatz; H Friedman
Arithmetic versus harmonic mean values of elimination half-life: a study of triazolam.
Journal of clinical pharmacology 1989;29(7):655-6.
1989: David J Greenblatt; B L Ehrenberg; J Gunderman; J M Scavone; N T Tai; Jerold S Harmatz; Richard I Shader
Kinetic and dynamic study of intravenous lorazepam: comparison with intravenous diazepam.
The Journal of pharmacology and experimental therapeutics 1989;250(1):134-40.
1989: H Friedman; David J Greenblatt; J M Scavone; E S Burstein; H R Ochs; Jerold S Harmatz; Richard I Shader
Clearance of the antihistamine doxylamine. Reduced in elderly men but not in elderly women.
Clinical pharmacokinetics 1989;16(5):312-6.
1989: David J Greenblatt; B L Ehrenberg; J Gunderman; A Locniskar; J M Scavone; Jerold S Harmatz; R I Shader
Pharmacokinetic and electroencephalographic study of intravenous diazepam, midazolam, and placebo.
Clinical pharmacology and therapeutics 1989;45(4):356-65.
1989: David J Greenblatt; Jerold S Harmatz; N Engelhardt; Richard I Shader
Pharmacokinetic determinants of dynamic differences among three benzodiazepine hypnotics. Flurazepam, temazepam, and triazolam.
Archives of general psychiatry 1989;46(4):326-32.
1989: B G Luna; J M Scavone; David J Greenblatt
Doxylamine and diphenhydramine pharmacokinetics in women on low-dose estrogen oral contraceptives.
Journal of clinical pharmacology 1989;29(3):257-60.
1989: J M Scavone; G T Blyden; David J Greenblatt
Lack of effect of influenza vaccine on the pharmacokinetics of antipyrine, alprazolam, paracetamol (acetaminophen) and lorazepam.
Clinical pharmacokinetics 1989;16(3):180-5.
1989: Gary B Kaplan; David J Greenblatt; B W Leduc; M L Thompson; Richard I Shader
Relationship of plasma and brain concentrations of caffeine and metabolites to benzodiazepine receptor binding and locomotor activity.
The Journal of pharmacology and experimental therapeutics 1989;248(3):1078-83.
1989: E S Burstein; David J Greenblatt
Simplified gas chromatographic analysis of ethanol in blood and tissue.
Journal of chromatography 1989;487(1):228-31.
1989: David J Greenblatt; M K Divoll; Darrell R. Abernethy; H R Ochs; Jerold S Harmatz; Richard I Shader
Age and gender effects on chlordiazepoxide kinetics: relation to antipyrine disposition.
Pharmacology 1989;38(5):327-34.
1988: Domenic A Ciraulo; J G Barnhill; David J Greenblatt; Richard I Shader; Ann Marie Ciraulo; M F Tarmey; M A Molloy; M E Foti
Abuse liability and clinical pharmacokinetics of alprazolam in alcoholic men.
The Journal of clinical psychiatry 1988;49(9):333-7.
1988: David J Greenblatt; Jerold S Harmatz; C Dorsey; Richard I Shader
Comparative single-dose kinetics and dynamics of lorazepam, alprazolam, prazepam, and placebo.
Clinical pharmacology and therapeutics 1988;44(3):326-34.
1988: David J Greenblatt; M K Divoll; M H Soong; H G Boxenbaum; Jerold S Harmatz; Richard I Shader
Desmethyldiazepam pharmacokinetics: studies following intravenous and oral desmethyldiazepam, oral clorazepate, and intravenous diazepam.
Journal of clinical pharmacology 1988;28(9):853-9.
1988: J M Scavone; David J Greenblatt; G T Blyden; Jerold S Harmatz; P J Graziano
Simplified approaches to the determination of antipyrine pharmacokinetic parameters.
British journal of clinical pharmacology 1988;25(6):695-9.
1988: J M Scavone; David J Greenblatt; G T Blyden
Antipyrine pharmacokinetics in women receiving conjugated estrogens.
Journal of clinical pharmacology 1988;28(5):463-6.
1988: J M Scavone; David J Greenblatt; A Locniskar; R I Shader
Alprazolam pharmacokinetics in women on low-dose oral contraceptives.
Journal of clinical pharmacology 1988;28(5):454-7.
1988: E S Burstein; H Friedman; David J Greenblatt; A Locniskar; H R Ochs
Quantitation of flurazepam and three metabolites by electron capture gas liquid chromatography.
Journal of analytical toxicology 1988;12(3):122-5.
1988: L G Miller; David J Greenblatt; J G Barnhill; M L Thompson; R I Shaderh
Modulation of benzodiazepine receptor binding in mouse brain by adrenalectomy and steroid replacement.
Brain research 1988;446(2):314-20.
1988: G T Blyden; J M Scavone; David J Greenblatt
Metronidazole impairs clearance of phenytoin but not of alprazolam or lorazepam.
Journal of clinical pharmacology 1988;28(3):240-5.
1988: H Friedman; David J Greenblatt; E S Burstein; J M Scavone; Jerold S Harmatz; Richard I Shader
Triazolam kinetics: interaction with cimetidine, propranolol, and the combination.
Journal of clinical pharmacology 1988;28(3):228-33.
1988: L G Miller; David J Greenblatt; J G Barnhill; Richard I Shader
Differential modulation of benzodiazepine receptor binding by ethanol in LS and SS mice.
Pharmacology, biochemistry, and behavior 1988;29(3):471-7.
1988: David J Greenblatt; L R Engelking
Enterohepatic circulation of lorazepam and acetaminophen conjugates in ponies.
The Journal of pharmacology and experimental therapeutics 1988;244(2):674-9.
1988: A Locniskar; David J Greenblatt
High-performance liquid chromatographic assay of adinazolam and its desmethyl metabolite.
Journal of chromatography 1988;424(1):215-7.
1988: David J Greenblatt; M K Divoll; Jerold S Harmatz; Richard I Shader
Antipyrine absorption and disposition in the elderly.
Pharmacology 1988;36(2):125-33.
1988: J M Scavone; H R Ochs; David J Greenblatt; R Matlis
Pharmacokinetics of oxaprozin in women receiving conjugated estrogen.
European journal of clinical pharmacology 1988;35(1):105-8.
1988: G T Blyden; David J Greenblatt; B W LeDuc; J M Scavone
Effect of antipyrine coadministration on the kinetics of acetaminophen and lidocaine.
European journal of clinical pharmacology 1988;35(4):413-7.
1988: L G Miller; Stephen Irwin Deutsch; David J Greenblatt; S M Paul; R I Shader
Acute barbiturate administration increases benzodiazepine receptor binding in vivo.
Psychopharmacology 1988;96(3):385-90.
1988: L G Miller; David J Greenblatt; Darrell R. Abernethy; H Friedman; M D Luu; S M Paul; R I Shader
Kinetics, brain uptake, and receptor binding characteristics of flurazepam and its metabolites.
Psychopharmacology 1988;94(3):386-91.
1988: L G Miller; A Lee-Paritz; David J Greenblatt; T C Theoharides
High-affinity benzodiazepine binding sites on rat peritoneal mast cells and RBL-1 cells: binding characteristics and effects on granule secretion.
Pharmacology 1988;36(1):52-60.
1987: E S Burstein; H Friedman; David J Greenblatt
Simplified measurement of haloperidol by gas chromatography with nitrogen-phosphorus detection.
Journal of chromatography 1987;423():380-2.
1987: J S Kennedy; H Friedman; J M Scavone; Jerold S Harmatz; Richard I Shader; David J Greenblatt
Effect of blood collection tubes on antidepressant concentrations.
Journal of chromatography 1987;423():373-5.
1987: J S Kennedy; B W Leduc; J M Scavone; Jerold S Harmatz; Richard I Shader; David J Greenblatt
Pharmacokinetics of intravenous caffeine: comparison of high-performance liquid chromatographic and gas chromatographic methods.
Journal of chromatography 1987;422():274-80.
1987: J M Scavone; David J Greenblatt; R I Shader
Alprazolam kinetics following sublingual and oral administration.
Journal of clinical psychopharmacology 1987;7(5):332-4.
1987: David J Greenblatt; L G Miller; Richard I Shader
Clonazepam pharmacokinetics, brain uptake, and receptor interactions.
The Journal of clinical psychiatry 1987;48 Suppl():4-11.
1987: J M Scavone; G P Meneilly; David J Greenblatt; H Friedman
Gas chromatographic analysis of underivatized tocainide.
Journal of chromatography 1987;419():339-44.
1987: David J Greenblatt; H Friedman; E S Burstein; J M Scavone; G T Blyden; H R Ochs; L G Miller; Jerold S Harmatz; R I Shader
Trazodone kinetics: effect of age, gender, and obesity.
Clinical pharmacology and therapeutics 1987;42(2):193-200.
1987: H R Ochs; David J Greenblatt; H Friedman; E S Burstein; A Locniskar; Jerold S Harmatz; Richard I Shader
Bromazepam pharmacokinetics: influence of age, gender, oral contraceptives, cimetidine, and propranolol.
Clinical pharmacology and therapeutics 1987;41(5):562-70.
1987: David J Greenblatt; Richard I Shader
Drug absorption rate: a critical component of bioequivalence assessment in psychopharmacology.
Journal of clinical pharmacology 1987;27(2):85-6.
1987: Jerold S Harmatz; David J Greenblatt
A simplex procedure for fitting nonlinear pharmacokinetic models.
Computers in biology and medicine 1987;17(3):199-208.
1986: G T Blyden; David J Greenblatt; J M Scavone; R I Shader
Pharmacokinetics of diphenhydramine and a demethylated metabolite following intravenous and oral administration.
Journal of clinical pharmacology 1986;26(7):529-33.
1986: Domenic A Ciraulo; J G Barnhill; H G Boxenbaum; David J Greenblatt; R B Smith
Pharmacokinetics and clinical effects of alprazolam following single and multiple oral doses in patients with panic disorder.
Journal of clinical pharmacology 1986;26(4):292-8.
1986: David J Greenblatt; A Locniskar; J M Scavone; G T Blyden; H R Ochs; Jerold S Harmatz; R I Shader
Absence of interaction of cimetidine and ranitidine with intravenous and oral midazolam.
Anesthesia and analgesia 1986;65(2):176-80.
1986: J M Scavone; David J Greenblatt; R Matlis; Jerold S Harmatz
Interaction of oxaprozin with acetaminophen, cimetidine, and ranitidine.
European journal of clinical pharmacology 1986;31(3):371-4.
1986: G T Blyden; B W LeDuc; David J Greenblatt
Large theophylline requirements due to high theophylline clearance: verification by the antipyrine test.
Pharmacology 1986;32(4):226-31.
1985: David J Greenblatt; R Matlis; J M Scavone; G T Blyden; Jerold S Harmatz; R I Shader
Oxaprozin pharmacokinetics in the elderly.
British journal of clinical pharmacology 1985;19(3):373-8.