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Douglas Greene

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Catherine L Martin; James Albers; William H Herman; Patricia Cleary; Barbara Waberski; Douglas A Greene; Martin J Stevens; Eva L Feldman
Neuropathy among the diabetes control and complications trial cohort 8 years after trial completion.
Eitaro Nakashima; Rodica Pop-Busui; Roberto Towns; Thommey P Thomas; Yoshiuki Hosaka; Jiro Nakamura; Douglas A Greene; Paul D Killen; Justin Schroeder; Dennis Larkin; Yuk Lam Ho; Martin J Stevens
Regulation of the human taurine transporter by oxidative stress in retinal pigment epithelial cells stably transformed to overexpress aldose reductase.
Martin J Stevens; Dennis Larkin; Eva L Feldman; Monte A Delmonte; Douglas A Greene
Establishment, maintenance, and transfection of in vitro cultures of human retinal pigment epithelium.

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All Publications

2006: Catherine L Martin; James Albers; William H Herman; Patricia Cleary; Barbara Waberski; Douglas A Greene; Martin J Stevens; Eva L Feldman
Neuropathy among the diabetes control and complications trial cohort 8 years after trial completion.
Diabetes care 2006;29(2):340-4.
2005: Eitaro Nakashima; Rodica Pop-Busui; Roberto Towns; Thommey P Thomas; Yoshiuki Hosaka; Jiro Nakamura; Douglas A Greene; Paul D Killen; Justin Schroeder; Dennis Larkin; Yuk Lam Ho; Martin J Stevens
Regulation of the human taurine transporter by oxidative stress in retinal pigment epithelial cells stably transformed to overexpress aldose reductase.
Antioxidants & redox signaling 2005;7(11-12):1530-42.
2005: Martin J Stevens; Dennis Larkin; Eva L Feldman; Monte A Delmonte; Douglas A Greene
Establishment, maintenance, and transfection of in vitro cultures of human retinal pigment epithelium.
Methods in molecular medicine 2005;107():343-51.
2003: Kelli A Sullivan; M S Brown; L Harmon; Douglas A Greene
Digital electron microscopic examination of human sural nerve biopsies.
Journal of the peripheral nervous system : JPNS 2003;8(4):260-70.
2003: Soley Thrainsdottir; Rayez A Malik; Lars B Dahlin; Peter Wiksell; Karl-Fredrik Eriksson; Ingmar Rosén; Jesper Petersson; Douglas A Greene; Göran Sundkvist
Endoneurial capillary abnormalities presage deterioration of glucose tolerance and accompany peripheral neuropathy in man.
Diabetes 2003;52(10):2615-22.
2003: Liza L Ilag; Catherine L Martin; Bahman P Tabaei; Deanna J M Isaman; Ray Burke; Douglas A Greene; William H Herman
Improving diabetes processes of care in managed care.
Diabetes care 2003;26(10):2722-7.
2002: Giancarlo Viberti; Steven E Kahn; Douglas A Greene; William H Herman; Bernard Zinman; Rury R Holman; Steven M Haffner; Daniel Levy; John M Lachin; Rhona A Berry; Mark A Heise; Nigel P Jones; Freed Martin
A diabetes outcome progression trial (ADOPT): an international multicenter study of the comparative efficacy of rosiglitazone, glyburide, and metformin in recently diagnosed type 2 diabetes.
Diabetes care 2002;25(10):1737-43.
2002: Rodica Pop-Busui; Vlad Marinescu; Carol Van Huysen; Fei Li; Kelli A Sullivan; Douglas A Greene; Dennis Larkin; Martin J Stevens
Dissection of metabolic, vascular, and nerve conduction interrelationships in experimental diabetic neuropathy by cyclooxygenase inhibition and acetyl-L-carnitine administration.
Diabetes 2002;51(8):2619-28.
2002: Irina G Obrosova; Carol Van Huysen; Lamia Fathallah; Xianghui Cao Cao; Douglas A Greene; Martin J Stevens
An aldose reductase inhibitor reverses early diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(1):123-5.
2000: Irina G Obrosova; Carol Van Huysen; Lamia Fathallah; X Cao; Martin J Stevens; Douglas A Greene
Evaluation of alpha(1)-adrenoceptor antagonist on diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(11):1548-58.
2000: Irina G Obrosova; Lamia Fathallah; Douglas A Greene
Early changes in lipid peroxidation and antioxidative defense in diabetic rat retina: effect of DL-alpha-lipoic acid.
European journal of pharmacology 2000;398(1):139-46.
2000: Martin J Stevens; Irina G Obrosova; X Cao; Carol Van Huysen; Douglas A Greene
Effects of DL-alpha-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy.
Diabetes 2000;49(6):1006-15.
2000: Göran Sundkvist; Lars B Dahlin; H Nilsson; Karl-Fredrik Eriksson; Folke Lindgärde; I Rosén; S A Lattimer; Anders A F Sima; Kelli A Sullivan; Douglas A Greene
Sorbitol and myo-inositol levels and morphology of sural nerve in relation to peripheral nerve function and clinical neuropathy in men with diabetic, impaired, and normal glucose tolerance.
Diabetic medicine : a journal of the British Diabetic Association 2000;17(4):259-68.
2000: Yadollah Harati; Clifton L Gooch; M Swenson; S V Edelman; Douglas A Greene; Philip Raskin; Peter D Donofrio; David R Cornblath; William H Olson; Marc Kamin
Maintenance of the long-term effectiveness of tramadol in treatment of the pain of diabetic neuropathy.
Journal of diabetes and its complications 2000;14(2):65-70.
1999: Irina G Obrosova; Lamia Fathallah; HJ Lang; Douglas A Greene
Evaluation of a sorbitol dehydrogenase inhibitor on diabetic peripheral nerve metabolism: a prevention study.
Diabetologia 1999;42(10):1187-94.
1999: Douglas A Greene; Martin J Stevens; Eva L Feldman
Diabetic neuropathy: scope of the syndrome.
The American journal of medicine 1999;107(2B):2S-8S.
1999: Douglas A Greene; Joseph C Arezzo; M B Brown
Effect of aldose reductase inhibition on nerve conduction and morphometry in diabetic neuropathy. Zenarestat Study Group.
Neurology 1999;53(3):580-91.
1999: K Kato; Thommey P Thomas; Martin J Stevens; Douglas A Greene; J Nakamura
2-Chloroadenosine reverses hyperglycemia-induced inhibition of phosphoinositide synthesis in cultured human retinal pigment epithelial cells and prevents reduced nerve conduction velocity in diabetic rats.
Metabolism: clinical and experimental 1999;48(7):827-33.
1999: Douglas A Greene; Martin J Stevens; Irina G Obrosova; Eva L Feldman
Glucose-induced oxidative stress and programmed cell death in diabetic neuropathy.
European journal of pharmacology 1999;375(1-3):217-23.
1999: Francesca Porcellati; Yoshiuki Hosaka; T Hlaing; M Togawa; Dennis Larkin; A Karihaloo; Martin J Stevens; Paul D Killen; Douglas A Greene
Alternate splicing in human Na+-MI cotransporter gene yields differentially regulated transport isoforms.
The American journal of physiology 1999;276(6 Pt 1):C1325-37.
1999: Robert V Hogikyan; J J Wald; Eva L Feldman; Douglas A Greene; Jeffrey B Halter; Mark A Supiano
Acute effects of adrenergic-mediated ischemia on nerve conduction in subjects with type 2 diabetes.
Metabolism: clinical and experimental 1999;48(4):495-500.
1998: Irina G Obrosova; X Cao; Douglas A Greene; Martin J Stevens
Diabetes-induced changes in lens antioxidant status, glucose utilization and energy metabolism: effect of DL-alpha-lipoic acid.
Diabetologia 1998;41(12):1442-50.
1998: Yadollah Harati; Clifton L Gooch; M Swenson; S Edelman; Douglas A Greene; Philip Raskin; Peter D Donofrio; David R Cornblath; R Sachdeo; C O Siu; Marc Kamin
Double-blind randomized trial of tramadol for the treatment of the pain of diabetic neuropathy.
Neurology 1998;50(6):1842-6.
1998: Robert V Hogikyan; Andrzej T Galecki; Bertram Pitt; Jeffrey B Halter; Douglas A Greene; Mark A Supiano
Specific impairment of endothelium-dependent vasodilation in subjects with type 2 diabetes independent of obesity.
The Journal of clinical endocrinology and metabolism 1998;83(6):1946-52.
1998: Francesca Porcellati; T Hlaing; M Togawa; Martin J Stevens; Dennis Larkin; Yoshiuki Hosaka; Thomas W Glover; D N Henry; Douglas A Greene; Paul D Killen
Human Na(+)-myo-inositol cotransporter gene: alternate splicing generates diverse transcripts.
The American journal of physiology 1998;274(5 Pt 1):C1215-25.
1998: P Magnani; Thommey P Thomas; Gihan I. Tennekoon; George Henry De Vries; Douglas A Greene; Frank C Brosius III
Regulation of glucose transport in cultured Schwann cells.
Journal of the peripheral nervous system : JPNS 1998;3(1):28-36.
1997: A Karihaloo; K Kato; Douglas A Greene; Thommey P Thomas
Protein kinase and Ca2+ modulation of myo-inositol transport in cultured retinal pigment epithelial cells.
The American journal of physiology 1997;273(2 Pt 1):C671-8.
1997: Anders A F Sima; Joyce A Dunlap; Eric P Davidson; Thomas Wiese; R L Lightle; Douglas A Greene; Mark A Yorek
Supplemental myo-inositol prevents L-fucose-induced diabetic neuropathy.
Diabetes 1997;46(2):301-6.
1997: Eva L Feldman; Martin J Stevens; Douglas A Greene
Pathogenesis of diabetic neuropathy.
Clinical neuroscience (New York, N.Y.) 1997;4(6):365-70.
1996: P Magnani; P V Cherian; G W Gould; Douglas A Greene; Anders A F Sima; Frank C Brosius III
Glucose transporters in rat peripheral nerve: paranodal expression of GLUT1 and GLUT3.
Metabolism: clinical and experimental 1996;45(12):1466-73.
1996: Martin J Stevens; S A Lattimer; Eva L Feldman; E D Helton; D S Millington; Anders A F Sima; Douglas A Greene
Acetyl-L-carnitine deficiency as a cause of altered nerve myo-inositol content, Na,K-ATPase activity, and motor conduction velocity in the streptozotocin-diabetic rat.
Metabolism: clinical and experimental 1996;45(7):865-72.
1996: Anders A F Sima; H Ristic; A Merry; M Kamijo; S A Lattimer; Martin J Stevens; Douglas A Greene
Primary preventive and secondary interventionary effects of acetyl-L-carnitine on diabetic neuropathy in the bio-breeding Worcester rat.
The Journal of clinical investigation 1996;97(8):1900-7.
1996: H Shindo; Thommey P Thomas; Dennis Larkin; A K Karihaloo; H Inada; Toshimasa Onaya; Martin J Stevens; Douglas A Greene
Modulation of basal nitric oxide-dependent cyclic-GMP production by ambient glucose, myo-inositol, and protein kinase C in SH-SY5Y human neuroblastoma cells.
The Journal of clinical investigation 1996;97(3):736-45.
1996: Eva L Feldman; Monte A Delmonte; Martin J Stevens; Douglas A Greene
Establishment and maintenance of in vitro cultures of human retinal pigment epithelium.
Methods in molecular medicine 1996;2():517-24.
1996: James Albers; M B Brown; Anders A F Sima; Douglas A Greene
Nerve conduction measures in mild diabetic neuropathy in the Early Diabetes Intervention Trial: the effects of age, sex, type of diabetes, disease duration, and anthropometric factors. Tolrestat Study Group for the Early Diabetes Intervention Trial.
Neurology 1996;46(1):85-91.
1995: Martin J Stevens; Eva L Feldman; Douglas A Greene
The aetiology of diabetic neuropathy: the combined roles of metabolic and vascular defects.
Diabetic medicine : a journal of the British Diabetic Association 1995;12(7):566-79.
1995: Anders A F Sima; Douglas A Greene
Diabetic neuropathy in the elderly.
Drugs & aging 1995;6(2):125-35.
1994: J Nakamura; S A Lattimer; Douglas A Greene
Transphosphatidylation of sugar alcohols and its implications for the pathogenesis of diabetic complications.
Diabetologia 1994;37(11):1147-53.
1994: Eva L Feldman; Martin J Stevens; P K Thomas; M B Brown; N Canal; Douglas A Greene
A practical two-step quantitative clinical and electrophysiological assessment for the diagnosis and staging of diabetic neuropathy.
Diabetes care 1994;17(11):1281-9.
1994: Martin J Stevens; J Dananberg; Eva L Feldman; S A Lattimer; M Kamijo; Thommey P Thomas; H Shindo; Anders A F Sima; Douglas A Greene
The linked roles of nitric oxide, aldose reductase and, (Na+,K+)-ATPase in the slowing of nerve conduction in the streptozotocin diabetic rat.
The Journal of clinical investigation 1994;94(2):853-9.
1994: Thommey P Thomas; Francesca Porcellati; K Kato; Martin J Stevens; W R Sherman; Douglas A Greene
Effects of glucose on sorbitol pathway activation, cellular redox, and metabolism of myo-inositol, phosphoinositide, and diacylglycerol in cultured human retinal pigment epithelial cells.
The Journal of clinical investigation 1994;93(6):2718-24.
1993: Thommey P Thomas; Eva L Feldman; J Nakamura; K Kato; M Lien; Martin J Stevens; Douglas A Greene
Ambient glucose and aldose reductase-induced myo-inositol depletion modulate basal and carbachol-stimulated inositol phospholipid metabolism and diacylglycerol accumulation in human retinal pigment epithelial cells in culture.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(20):9712-6.
1993: Mark A Yorek; Thomas Wiese; Eric P Davidson; Joyce A Dunlap; M R Stefani; C E Conner; S A Lattimer; M Kamijo; Douglas A Greene; Anders A F Sima
Reduced motor nerve conduction velocity and Na(+)-K(+)-ATPase activity in rats maintained on L-fucose diet. Reversal by myo-inositol supplementation.
Diabetes 1993;42(10):1401-6.
1993: Douglas A Greene; Anders A F Sima; Martin J Stevens; Eva L Feldman; Paul D Killen; D N Henry; Thommey P Thomas; J Dananberg; S A Lattimer
Aldose reductase inhibitors: an approach to the treatment of diabetic nerve damage.
Diabetes/metabolism reviews 1993;9(3):189-217.
1993: Martin J Stevens; D N Henry; Thommey P Thomas; Paul D Killen; Douglas A Greene
Aldose reductase gene expression and osmotic dysregulation in cultured human retinal pigment epithelial cells.
The American journal of physiology 1993;265(3 Pt 1):E428-38.
1993: D N Henry; Monte A Delmonte; Douglas A Greene; Paul D Killen
Altered aldose reductase gene regulation in cultured human retinal pigment epithelial cells.
The Journal of clinical investigation 1993;92(2):617-23.
1993: Martin J Stevens; S A Lattimer; M Kamijo; C Van Huysen; Anders A F Sima; Douglas A Greene
Osmotically-induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy in the rat.
Diabetologia 1993;36(7):608-14.
1993: Anders A F Sima; Douglas A Greene; M B Brown; TC Hohman; D Hicks; G J Graepel; W J Bochenek; M Beg; B Gonen
Effect of hyperglycemia and the aldose reductase inhibitor tolrestat on sural nerve biochemistry and morphometry in advanced diabetic peripheral polyneuropathy. The Tolrestat Study Group.
Journal of diabetes and its complications 1993;7(3):157-69.
1993: Anders A F Sima; A Prashar; V Nathaniel; Vera Bril; M R Werb; Douglas A Greene
Overt diabetic neuropathy: repair of axo-glial dysjunction and axonal atrophy by aldose reductase inhibition and its correlation to improvement in nerve conduction velocity.
Diabetic medicine : a journal of the British Diabetic Association 1993;10(2):115-21.
1993: Anders A F Sima; Douglas A Greene
Structural-functional interactions in the therapeutic response of diabetic neuropathy.
Diabetic medicine : a journal of the British Diabetic Association 1993;10 Suppl 2():33S-34S.
1992: Douglas A Greene; Anders A F Sima; Martin J Stevens; Eva L Feldman; S A Lattimer
Complications: neuropathy, pathogenetic considerations.
Diabetes care 1992;15(12):1902-25.
1992: Anders A F Sima; M B Brown; A Prashar; Subrata Chakrabarti; C Laudadio; Douglas A Greene
The reproducibility and sensitivity of sural nerve morphometry in the assessment of diabetic peripheral polyneuropathy.
Diabetologia 1992;35(6):560-9.
1992: J Nakamura; Monte A Delmonte; Donna S Shewach; S A Lattimer; Douglas A Greene
Inhibition of phosphatidylinositol synthase by glucose in human retinal pigment epithelial cells.
The American journal of physiology 1992;262(4 Pt 1):E417-26.
1992: Douglas A Greene
Effects of aldose reductase inhibitors on the progression of nerve fiber damage in diabetic neuropathy.
Journal of diabetes and its complications 1992;6(1):35-8.
1991: Monte A Delmonte; R Rabbani; T C Diaz; S A Lattimer; J Nakamura; M C Brennan; Douglas A Greene
Sorbitol, myo-inositol, and rod outer segment phagocytosis in cultured hRPE cells exposed to glucose. In vitro model of myo-inositol depletion hypothesis of diabetic complications.
Diabetes 1991;40(10):1335-45.
1991: Anders A F Sima; V Nathaniel; A Prashar; Vera Bril; Douglas A Greene
Endoneurial microvessels in human diabetic neuropathy. Endothelial cell dysjunction and lack of treatment effect by aldose reductase inhibitor.
Diabetes 1991;40(9):1090-9.
1991: Eva L Feldman; A E Randolph; G C Johnston; Monte A Delmonte; Douglas A Greene
Receptor-coupled phosphoinositide hydrolysis in human retinal pigment epithelium.
Journal of neurochemistry 1991;56(6):2094-100.
1991: Anders A F Sima; V Nathaniel; Douglas A Greene
Peripheral nerve repair following ARI treatment.
Advances in experimental medicine and biology 1991;291():265-70.
1990: Anders A F Sima; A Prashar; W X Zhang; Subrata Chakrabarti; Douglas A Greene
Preventive effect of long-term aldose reductase inhibition (ponalrestat) on nerve conduction and sural nerve structure in the spontaneously diabetic Bio-Breeding rat.
The Journal of clinical investigation 1990;85(5):1410-20.
1990: W X Zhang; Subrata Chakrabarti; Douglas A Greene; Anders A F Sima
Diabetic autonomic neuropathy in BB rats and effect of ARI treatment on heart-rate variability and vagus nerve structure.
Diabetes 1990;39(5):613-8.
1989: Anders A F Sima; W X Zhang; Douglas A Greene
Diabetic and hypoglycemic neuropathy--a comparison in the BB rat.
Diabetes research and clinical practice 1989;6(4):279-96.
1989: S A Lattimer; Anders A F Sima; Douglas A Greene
In vitro correction of impaired Na+-K+-ATPase in diabetic nerve by protein kinase C agonists.
The American journal of physiology 1989;256(2 Pt 1):E264-9.
1989: Douglas A Greene; S Lattimer-Greene; Anders A F Sima
Pathogenesis of diabetic neuropathy: role of altered phosphoinositide metabolism.
Critical reviews in neurobiology 1989;5(2):143-219.
1988: Anders A F Sima; Vera Bril; V Nathaniel; T A McEwen; M B Brown; S A Lattimer; Douglas A Greene
Regeneration and repair of myelinated fibers in sural-nerve biopsy specimens from patients with diabetic neuropathy treated with sorbinil.
The New England journal of medicine 1988;319(9):548-55.
1988: Douglas A Greene; S A Lattimer; Anders A F Sima
Are disturbances of sorbitol, phosphoinositide, and Na+-K+-ATPase regulation involved in pathogenesis of diabetic neuropathy?
Diabetes 1988;37(6):688-93.
1988: Douglas A Greene; S A Lattimer; Anders A F Sima
Pathogenesis and prevention of diabetic neuropathy.
Diabetes/metabolism reviews 1988;4(3):201-21.
1988: Anders A F Sima; V Nathaniel; Vera Bril; T A McEwen; Douglas A Greene
Histopathological heterogeneity of neuropathy in insulin-dependent and non-insulin-dependent diabetes, and demonstration of axo-glial dysjunction in human diabetic neuropathy.
The Journal of clinical investigation 1988;81(2):349-64.