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Iain Greenwood

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W-S Vanessa Ho; Preet S Chadha; Alison J Davis; Iain A Greenwood
Effective contractile response to voltage-gated Na+ channels revealed by a channel activator.
Alison J Davis; Anthony P Albert; Preet S Chadha; Normand Leblanc; Harry A T Pritchard; Jian Shi; Georgios Vasilikostas; Zhen Yao; A S Verkman; Iain A Greenwood
Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01.
Abigail S Forrest; Natalie Freitas; Iain A Greenwood; Marissa L Huebner; John Joyce; Talia C Joyce; Cherie A Singer; Maria L Valencik; Michael Wiwchar; Linda Ye; Ramon J Ayon; Alison J Davis; Dayue D Duan; Normand Leblanc
Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension.

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All Publications

2013: W-S Vanessa Ho; Preet S Chadha; Alison J Davis; Iain A Greenwood
Effective contractile response to voltage-gated Na+ channels revealed by a channel activator.
American journal of physiology. Cell physiology 2013;304(8):C739-47.
2013: Alison J Davis; Anthony P Albert; Preet S Chadha; Normand Leblanc; Harry A T Pritchard; Jian Shi; Georgios Vasilikostas; Zhen Yao; A S Verkman; Iain A Greenwood
Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01.
British journal of pharmacology 2013;168(3):773-84.
2012: Abigail S Forrest; Natalie Freitas; Iain A Greenwood; Marissa L Huebner; John Joyce; Talia C Joyce; Cherie A Singer; Maria L Valencik; Michael Wiwchar; Linda Ye; Ramon J Ayon; Alison J Davis; Dayue D Duan; Normand Leblanc
Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension.
American journal of physiology. Cell physiology 2012;303(12):C1229-43.
2012: Maksym I Harhun; Christopher L Huggins; Teck K Khong; Ray F Moss; Durgesh Raje; Kumaran Ratnasingham; Kinga Szewczyk; Georgios Vasilikostas; Andrew Wan; Iain A Greenwood; Marcus Reddy
Resident phenotypically modulated vascular smooth muscle cells in healthy human arteries.
Journal of cellular and molecular medicine 2012;16(11):2802-12.
2012: Jeff Erik Angermann; Abigail S Forrest; Iain A Greenwood; Normand Leblanc
Activation of Ca2+-activated Cl- channels by store-operated Ca2+ entry in arterial smooth muscle cells does not require reverse-mode Na+/Ca2+ exchange.
Canadian journal of physiology and pharmacology 2012;90(7):903-21.
2012: Preet S Chadha; Alison J Davis; Thomas A Jepps; Joannes T M Linders; Michael Schwake; Robertson (Rob) Towart; Friederike Zunke; Iain A Greenwood
Pharmacological dissection of K(v)7.1 channels in systemic and pulmonary arteries.
British journal of pharmacology 2012;166(4):1377-87.
2012: Preet S Chadha; William C Cole; Alison J Davis; Thomas A Jepps; James D Moffatt; Søren P Olesen; Hai-Lei Zhu; Friederike Zunke; Iain A Greenwood
Reduced KCNQ4-encoded voltage-dependent potassium channel activity underlies impaired β-adrenoceptor-mediated relaxation of renal arteries in hypertension.
Hypertension 2012;59(4):877-84.
2011: Hiten D Mistry; Fiona Broughton Pipkin; Iain A Greenwood; Lesia O Kurlak; Laura A McCallum; Rachel Tribe
Novel expression and regulation of voltage-dependent potassium channels in placentas from women with preeclampsia.
Hypertension 2011;58(3):497-504.
2011: Preet S Chadha; Iain A Greenwood; X Zoë Zhong; William C Cole
Letter to the editor re Mani et al.
British journal of pharmacology 2011;164(2):250-1; author reply 252-3.
2011: Thomas A Jepps; Søren P Olesen; Rie S Hansen; Maksym I Harhun; Preet S Chadha; Gillian W Cockerill; Alison J Davis; Iain A Greenwood
Downregulation of Kv7.4 channel activity in primary and secondary hypertension.
Circulation 2011;124(5):602-11.
2011: Fu Liang Ng; Alison J Davis; Thomas A Jepps; Maksym I Harhun; Shuk Yin Yeung; Andrew Wan; Marcus Reddy; David Melville; Antonio Nardi; Teck K Khong; Iain A Greenwood
Expression and function of the K+ channel KCNQ genes in human arteries.
British journal of pharmacology 2011;162(1):42-53.
2010: Alison J Davis; Abigail S Forrest; Thomas A Jepps; Maria L Valencik; Michael Wiwchar; Cherie A Singer; William R Sones; Iain A Greenwood; Normand Leblanc
Expression profile and protein translation of TMEM16A in murine smooth muscle.
American journal of physiology. Cell physiology 2010;299(5):C948-59.
2010: Xi Zoë Zhong; Maksym I Harhun; Soren P Olesen; Susumu Ohya; James D Moffatt; William C Cole; Iain A Greenwood
Participation of KCNQ (Kv7) potassium channels in myogenic control of cerebral arterial diameter.
The Journal of physiology 2010;588(Pt 17):3277-93.
2010: William R Sones; Alison J Davis; Normand Leblanc; Iain A Greenwood
Cholesterol depletion alters amplitude and pharmacology of vascular calcium-activated chloride channels.
Cardiovascular research 2010;87(3):476-84.
2010: Abigail S Forrest; Jeff Erik Angermann; Rajesh Raghunathan; Catherine Lachendro; Iain A Greenwood; Normand Leblanc
Intricate interaction between store-operated calcium entry and calcium-activated chloride channels in pulmonary artery smooth muscle cells.
Advances in experimental medicine and biology 2010;661():31-55.
2009: William R Sones; Normand Leblanc; Iain A Greenwood
Inhibition of vascular calcium-gated chloride currents by blockers of KCa1.1, but not by modulators of KCa2.1 or KCa2.3 channels.
British journal of pharmacology 2009;158(2):521-31.
2009: Iain A Greenwood; Shuk Yin M Yeung; Rachel Tribe; Susumu Ohya
Loss of functional K+ channels encoded by ether-à-go-go-related genes in mouse myometrium prior to labour onset.
The Journal of physiology 2009;587(Pt 10):2313-26.
2009: Iain A Greenwood; Susumu Ohya
New tricks for old dogs: KCNQ expression and role in smooth muscle.
British journal of pharmacology 2009;156(8):1196-203.
2009: Iain A Greenwood; S Y M Yeung; S Hettiarachi; M Andersson; Deborah L Baines
KCNQ-encoded channels regulate Na+ transport across H441 lung epithelial cells.
Pflügers Archiv : European journal of physiology 2009;457(4):785-94.
2008: Sym Yeung; M Schwake; Vladimir Pucovsky; Iain A Greenwood
Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents.
British journal of pharmacology 2008;155(1):62-72.
2008: Shuk Yin M Yeung; Wienke Lange; Michael Schwake; Iain A Greenwood
Expression profile and characterisation of a truncated KCNQ5 splice variant.
Biochemical and biophysical research communications 2008;371(4):741-6.
2007: Shuk Yin M Yeung; Vladimir Pucovsky; J D Moffatt; L Saldanha; M Schwake; Susumu Ohya; Iain A Greenwood
Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity.
British journal of pharmacology 2007;151(6):758-70.
2007: Sohag N Saleh; Jeff Erik Angermann; William R Sones; Normand Leblanc; Iain A Greenwood
Stimulation of Ca2+-gated Cl- currents by the calcium-dependent K+ channel modulators NS1619 [1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one] and isopimaric acid.
The Journal of pharmacology and experimental therapeutics 2007;321(3):1075-84.
2007: Iain A Greenwood; Normand Leblanc
Overlapping pharmacology of Ca2+-activated Cl- and K+ channels.
Trends in pharmacological sciences 2007;28(1):1-5.
2007: Shuk Yin M Yeung; Iain A Greenwood
Pharmacological and biophysical isolation of K+ currents encoded by ether-à-go-go-related genes in murine hepatic portal vein smooth muscle cells.
American journal of physiology. Cell physiology 2007;292(1):C468-76.
2006: Shuk Yin M Yeung; Susumu Ohya; Gerard P Sergeant; Vladimir Pucovsky; Iain A Greenwood
Pharmacological and molecular evidence for the involvement of Kv4.3 in ultra-fast activating K+ currents in murine portal vein myocytes.
British journal of pharmacology 2006;149(6):676-86.
2006: Jeff Erik Angermann; Amy Sanguinetti; James L Kenyon; Normand Leblanc; Iain A Greenwood
Mechanism of the inhibition of Ca2+-activated Cl- currents by phosphorylation in pulmonary arterial smooth muscle cells.
The Journal of general physiology 2006;128(1):73-87.
2005: Shuk Yin M Yeung; Iain A Greenwood
Electrophysiological and functional effects of the KCNQ channel blocker XE991 on murine portal vein smooth muscle cells.
British journal of pharmacology 2005;146(4):585-95.
2005: Sohag N Saleh; Shuk Yin M Yeung; Sally Prestwich; Vladimir Pucovsky; Iain A Greenwood
Electrophysiological and molecular identification of voltage-gated sodium channels in murine vascular myocytes.
The Journal of physiology 2005;568(Pt 1):155-69.
2005: Normand Leblanc; Jonathan Ledoux; Sohag N Saleh; Amy Sanguinetti; Jeff Erik Angermann; Kate O'Driscoll; Fiona C Britton; Brian A Perrino; Iain A Greenwood
Regulation of calcium-activated chloride channels in smooth muscle cells: a complex picture is emerging.
Canadian journal of physiology and pharmacology 2005;83(7):541-56.
2005: Jonathan Ledoux; Iain A Greenwood; Normand Leblanc
Dynamics of Ca2+-dependent Cl- channel modulation by niflumic acid in rabbit coronary arterial myocytes.
Molecular pharmacology 2005;67(1):163-73.
2005: Sohag N Saleh; Iain A Greenwood
Activation of chloride currents in murine portal vein smooth muscle cells by membrane depolarization involves intracellular calcium release.
American journal of physiology. Cell physiology 2005;288(1):C122-31.
2004: Iain A Greenwood; Jonathan Ledoux; Amy Sanguinetti; Brian A Perrino; Normand Leblanc
Calcineurin Aalpha but not Abeta augments ICl(Ca) in rabbit pulmonary artery smooth muscle cells.
The Journal of biological chemistry 2004;279(37):38830-7.
2004: Iain A Greenwood
CLC-3 knockout hints at swelling-activated chloride channel complexity.
The Journal of physiology 2004;557(Pt 2):343.
2003: Jonathan Ledoux; Iain A Greenwood; Louis Villeneuve; Normand Leblanc
Modulation of Ca2+-dependent Cl- channels by calcineurin in rabbit coronary arterial myocytes.
The Journal of physiology 2003;552(Pt 3):701-14.
2003: Susumu Ohya; Gerard P Sergeant; Iain A Greenwood; Burton Horowitz
Molecular variants of KCNQ channels expressed in murine portal vein myocytes: a role in delayed rectifier current.
Circulation research 2003;92(9):1016-23.
2003: Nick J Spencer; Iain A Greenwood
Characterization of properties underlying rhythmicity in mouse portal vein.
Autonomic neuroscience : basic & clinical 2003;104(2):73-82.
2003: Angela S Piper; Iain A Greenwood
Anomalous effect of anthracene-9-carboxylic acid on calcium-activated chloride currents in rabbit pulmonary artery smooth muscle cells.
British journal of pharmacology 2003;138(1):31-8.
2002: Susumu Ohya; Burton Horowitz; Iain A Greenwood
Functional and molecular identification of ERG channels in murine portal vein myocytes.
American journal of physiology. Cell physiology 2002;283(3):C866-77.
2002: D C Ellershaw; Iain A Greenwood; William A Large
Modulation of volume-sensitive chloride current by noradrenaline in rabbit portal vein myocytes.
The Journal of physiology 2002;542(Pt 2):537-47.
2002: Iain A Greenwood; Lisa J Miller; Susumu Ohya; Burton Horowitz
The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1.
The Journal of biological chemistry 2002;277(25):22119-22.
2002: Iain A Greenwood; SA Prestwich
Characteristics of hyperpolarization-activated cation currents in portal vein smooth muscle cells.
American journal of physiology. Cell physiology 2002;282(4):C744-53.
2002: Angela S Piper; Iain A Greenwood; William A Large
Dual effect of blocking agents on Ca2+-activated Cl(-) currents in rabbit pulmonary artery smooth muscle cells.
The Journal of physiology 2002;539(Pt 1):119-31.
2002: Fiona C Britton; Susumu Ohya; Burton Horowitz; Iain A Greenwood
Comparison of the properties of CLCA1 generated currents and I(Cl(Ca)) in murine portal vein smooth muscle cells.
The Journal of physiology 2002;539(Pt 1):107-17.
2002: Iain A Greenwood; Normand Leblanc; Dmitri V Gordienko; William A Large
Modulation of ICl(Ca) in vascular smooth muscle cells by oxidizing and cysteine-reactive reagents.
Pflügers Archiv : European journal of physiology 2002;443(3):473-82.
2001: Iain A Greenwood; Jonathan Ledoux; Normand Leblanc
Differential regulation of Ca(2+)-activated Cl(-) currents in rabbit arterial and portal vein smooth muscle cells by Ca(2+)-calmodulin-dependent kinase.
The Journal of physiology 2001;534(Pt. 2):395-408.
2001: Dmitri V Gordienko; Iain A Greenwood; Thomas B Bolton
Direct visualization of sarcoplasmic reticulum regions discharging Ca(2+)sparks in vascular myocytes.
Cell calcium 2001;29(1):13-28.
2000: J E Graves; Iain A Greenwood; William A Large
Tonic regulation of vascular tone by nitric oxide and chloride ions in rat isolated small coronary arteries.
American journal of physiology. Heart and circulatory physiology 2000;279(6):H2604-11.
2000: D C Ellershaw; Iain A Greenwood; William A Large
Dual modulation of swelling-activated chloride current by NO and NO donors in rabbit portal vein myocytes.
The Journal of physiology 2000;528 Pt 1():15-24.
1999: Iain A Greenwood; William A Large
Modulation of the decay of Ca2+-activated Cl- currents in rabbit portal vein smooth muscle cells by external anions.
The Journal of physiology 1999;516 ( Pt 2)():365-76.
1998: Iain A Greenwood; William A Large
Properties of a Cl- current activated by cell swelling in rabbit portal vein vascular smooth muscle cells.
The American journal of physiology 1998;275(5 Pt 2):H1524-32.
1997: Iain A Greenwood; RM Helliwell; William A Large
Modulation of Ca(2+)-activated Cl- currents in rabbit portal vein smooth muscle by an inhibitor of mitochondrial Ca2+ uptake.
The Journal of physiology 1997;505 ( Pt 1)():53-64.
1997: David N Criddle; R S de Moura; Iain A Greenwood; William A Large
Inhibitory action of niflumic acid on noradrenaline- and 5-hydroxytryptamine-induced pressor responses in the isolated mesenteric vascular bed of the rat.
British journal of pharmacology 1997;120(5):813-8.
1996: Iain A Greenwood; William A Large
Analysis of the time course of calcium-activated chloride "tail" currents in rabbit portal vein smooth muscle cells.
Pflügers Archiv : European journal of physiology 1996;432(6):970-9.
1996: D N Criddle; Roberto Soares de Moura; Iain A Greenwood; William A Large
Effect of niflumic acid on noradrenaline-induced contractions of the rat aorta.
British journal of pharmacology 1996;118(4):1065-71.
1996: C Toma; Iain A Greenwood; R M Helliwell; William A Large
Activation of potassium currents by inhibitors of calcium-activated chloride conductance in rabbit portal vein smooth muscle cells.
British journal of pharmacology 1996;118(3):513-20.
1995: Iain A Greenwood; William A Large
Comparison of the effects of fenamates on Ca-activated chloride and potassium currents in rabbit portal vein smooth muscle cells.
British journal of pharmacology 1995;116(7):2939-48.
1995: Iain A Greenwood; R C Hogg; William A Large
Effect of frusemide, ethacrynic acid and indanyloxyacetic acid on spontaneous Ca-activated currents in rabbit portal vein smooth muscle cells.
British journal of pharmacology 1995;115(5):733-8.
1994: D N Criddle; Iain A Greenwood; Arthur H Weston
Levcromakalim-induced modulation of membrane potassium currents, intracellular calcium and mechanical activity in rat mesenteric artery.
Naunyn-Schmiedeberg's archives of pharmacology 1994;349(4):422-30.
1993: Iain A Greenwood; Arthur H Weston
Effects of rubidium on responses to potassium channel openers in rat isolated aorta.
British journal of pharmacology 1993;109(4):925-32.