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Dale Greiner

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Hira Lal Goel; Dale L Greiner; Prashant Kumar; Charlotte Kuperwasser; Junhao Mao; Jens Henrik Norum; Bryan Pursell; Leslie M Shaw; Leonard D Shultz; Karl Simin; Rune Toftgard; Craig W Vander Kooi; Cheng Chang; Arthur M Mercurio
GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation.
Bhavana Priyadharshini; Thomas B Thornley; Raymond M Welsh; Amy Cuthbert; Keith A Daniels; Dale L Greiner; Michael A Brehm
Alloreactive CD8 T cells rescued from apoptosis during co-stimulation blockade by Toll-like receptor stimulation remain susceptible to Fas-induced cell death.
Leonard D Shultz; Michael A Brehm; J Victor Garcia-Martinez; Dale L Greiner
Humanized mice for immune system investigation: progress, promise and challenges.

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2013: Hira Lal Goel; Dale L Greiner; Prashant Kumar; Charlotte Kuperwasser; Junhao Mao; Jens Henrik Norum; Bryan Pursell; Leslie M Shaw; Leonard D Shultz; Karl Simin; Rune Toftgard; Craig W Vander Kooi; Cheng Chang; Arthur M Mercurio
GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation.
EMBO molecular medicine 2013;5(4):488-508.
2013: Bhavana Priyadharshini; Thomas B Thornley; Raymond M Welsh; Amy Cuthbert; Keith A Daniels; Dale L Greiner; Michael A Brehm
Alloreactive CD8 T cells rescued from apoptosis during co-stimulation blockade by Toll-like receptor stimulation remain susceptible to Fas-induced cell death.
Immunology 2013;138(4):322-32.
2012: Leonard D Shultz; Michael A Brehm; J Victor Garcia-Martinez; Dale L Greiner
Humanized mice for immune system investigation: progress, promise and challenges.
Nature reviews. Immunology 2012;12(11):786-98.
2012: Anette Hübner; Maria Karasarides; David J Mulholland; Charles L Sawyers; Claire L Standen; Cathy Tournier; Hong Wu; Tamera Barrett; Julie Cavanagh-Kyros; Hongbo Chi; Richard A Flavell; Dale L Greiner; Roger J Davis
JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(30):12046-51.
2012: Smita Jaiswal; Michael A Brehm; Dale L Greiner; Pamela Pazoles; Leonard D Shultz; Marcia Woda; Anuja Mathew
Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice.
Immunology 2012;136(3):334-43.
2012: Guozheng Liu; Mary Rusckowski; Leonard D Shultz; Philip R Streeter; Ali Akalin; Shuping Dou; Dale L Greiner
Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody.
Nuclear medicine and biology 2012;39(5):645-51.
2012: Michael A Brehm; Alvin C Powers; Leonard D Shultz; Dale L Greiner
Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice.
Cold Spring Harbor perspectives in medicine 2012;2(5):a007757.
2012: Zhijun Liu; Barak Yahalom; Elizabeth Blankenhorn; Laura Cort; Ryan Eberwine; Dale L Greiner; Thomas Herrmann; Jean H Leif; John P Mordes
Prevention of type 1 diabetes in the rat with an allele-specific anti-T-cell receptor antibody: Vβ13 as a therapeutic target and biomarker.
Diabetes 2012;61(5):1160-8.
2012: Michael A Brehm; Lisa M Burzenski; Raymond Dunn; Bruce Gott; Mary Herlihy; Vishnu Hosur; Ronald Ignotz; Jean Leif; Waldemar J Racki; Leonard D Shultz; Amber Wetmore; Dale L Greiner
Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2rγ null mice is enhanced by transgenic expression of membrane-bound human SCF.
Blood 2012;119(12):2778-88.
2011: Guozheng Liu; Shuping Dou; Dengfeng Cheng; Jean Leif; Mary Rusckowski; Philip R Streeter; Leonard D Shultz; Donald J Hnatowich; Dale L Greiner
Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant model.
Molecular pharmaceutics 2011;8(3):767-73.
2011: Kim M Wigglesworth; Waldemar J Racki; Rabinarayan Mishra; Eva Szomolanyi-Tsuda; Dale L Greiner; Uri Galili
Rapid recruitment and activation of macrophages by anti-Gal/α-Gal liposome interaction accelerates wound healing.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(7):4422-32.
2011: Marijke Niens; Alexandra E Grier; Michele P Marron; Thomas W H Kay; Dale L Greiner; David V Serreze
Prevention of "Humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach.
Diabetes 2011;60(4):1229-36.
2011: Madhumita Das; David S Garlick; Dale L Greiner; Roger J Davis
The role of JNK in the development of hepatocellular carcinoma.
Genes & development 2011;25(6):634-45.
2011: Annie J Kruger; Chaoxing Yang; Kathryn L Lipson; Stephen C Pino; Jean Leif; Christopher M Hogan; Barbara J Whalen; Dennis L Guberski; Young Lee; Roger H Unger; Dale L Greiner; Aldo A Rossini; Rita Bortell
Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats.
Autoimmunity 2011;44(2):137-48.
2011: Karin Przyklenk; Michelle Maynard; Dale L Greiner; Peter Whittaker
Cardioprotection with postconditioning: loss of efficacy in murine models of type-2 and type-1 diabetes.
Antioxidants & redox signaling 2011;14(5):781-90.
2011: Agata Jurczyk; Nicole Roy; Rabia Bajwa; Philipp Gut; Kathryn L Lipson; Chaoxing Yang; Laurence Covassin; Waldemar J Racki; Aldo A Rossini; Nancy Phillips; Didier Y R Stainier; Dale L Greiner; Michael A Brehm; Rita Bortell; Philip diIorio
Dynamic glucoregulation and mammalian-like responses to metabolic and developmental disruption in zebrafish.
General and comparative endocrinology 2011;170(2):334-45.
2010: Annie J Kruger; Chaoxing Yang; Sun W Tam; Douglas Hinerfeld; James E Evans; Karin M Green; John Leszyk; Kejian Yang; Dennis L Guberski; John P Mordes; Dale L Greiner; Aldo A Rossini; Rita Bortell
Haptoglobin as an early serum biomarker of virus-induced autoimmune type 1 diabetes in biobreeding diabetes resistant and LEW1.WR1 rats.
Experimental biology and medicine (Maywood, N.J.) 2010;235(11):1328-37.
2010: Michael A Brehm; Rita Bortell; Philip Diiorio; Jean Leif; Joseph Laning; Amy Cuthbert; Chaoxing Yang; Mary Herlihy; Lisa Burzenski; Bruce Gott; Oded Foreman; Alvin C Powers; Dale L Greiner; Leonard D Shultz
Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice.
Diabetes 2010;59(9):2265-70.
2010: Michael A Brehm; Keith A Daniels; B Priyadharshini; Thomas B Thornley; Dale L Greiner; Aldo A Rossini; Raymond M Welsh
Allografts stimulate cross-reactive virus-specific memory CD8 T cells with private specificity.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010;10(8):1738-48.
2010: Michael A Brehm; Leonard D Shultz; Dale L Greiner
Humanized mouse models to study human diseases.
Current opinion in endocrinology, diabetes, and obesity 2010;17(2):120-5.
2010: Michael A Brehm; Amy Cuthbert; Chaoxing Yang; David M Miller; Philip DiIorio; Joseph Laning; Lisa M Burzenski; Bruce Gott; Oded Foreman; Anoop Kavirayani; Mary Herlihy; Aldo A Rossini; Leonard D Shultz; Dale L Greiner
Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation.
Clinical immunology (Orlando, Fla.) 2010;135(1):84-98.
2010: Waldemar J Racki; Laurence Covassin; Michael Brehm; Stephen Pino; Ronald Ignotz; Raymond Dunn; Joseph Laning; Susannah K Graves; Aldo A Rossini; Leonard D Shultz; Dale L Greiner
NOD-scid IL2rgamma(null) mouse model of human skin transplantation and allograft rejection.
Transplantation 2010;89(5):527-36.
2010: Bhavana Priyadharshini; Raymond M Welsh; Dale L Greiner; Rachel M Gerstein; Michael A Brehm
Maturation-dependent licensing of naive T cells for rapid TNF production.
PloS one 2010;5(11):e15038.
2010: Agata Jurczyk; Steven C Pino; Bryan O'Sullivan-Murphy; Martha Addorio; Erich A Lidstone; Philip Diiorio; Kathryn L Lipson; Clive Standley; Kevin E Fogarty; Lawrence Lifshitz; Fumihiko Urano; John P Mordes; Dale L Greiner; Aldo A Rossini; Rita Bortell
A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells.
PloS one 2010;5(7):e11812.
2010: Steve Pino; Michael A Brehm; Laurence Covassin-Barberis; Marie King; Bruce Gott; Thomas H Chase; Jennifer Wagner; Lisa M Burzenski; Oded Foreman; Dale L Greiner; Leonard D Shultz
Development of novel major histocompatibility complex class I and class II-deficient NOD-SCID IL2R gamma chain knockout mice for modeling human xenogeneic graft-versus-host disease.
Methods in molecular biology (Clifton, N.J.) 2010;602():105-17.
2010: Rebecca Tirabassi; Dennis L Guberski; Elizabeth P Blankenhorn; Jean H Leif; Bruce A Woda; Zhijun Liu; Donald Winans; Dale L Greiner; John P Mordes
Infection with viruses from several families triggers autoimmune diabetes in LEW*1WR1 rats: prevention of diabetes by maternal immunization.
Diabetes 2010;59(1):110-8.
2009: Elizabeth P Blankenhorn; Laura Cort; Dale L Greiner; Dennis L Guberski; John P Mordes
Virus-induced autoimmune diabetes in the LEW.1WR1 rat requires Iddm14 and a genetic locus proximal to the major histocompatibility complex.
Diabetes 2009;58(12):2930-8.
2009: M A King; L Covassin; M A Brehm; W Racki; Todd Pearson; Jean Leif; J Laning; W Fodor; O Foreman; Lisa M Burzenski; T H Chase; Bruce Gott; Aldo A Rossini; R Bortell; Leonard D Shultz; Dale L Greiner
Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex.
Clinical and experimental immunology 2009;157(1):104-18.
2009: Prerna Chopra; Philip Diiorio; Steven C Pino; S Brian Wilson; Nancy E Phillips; John P Mordes; Aldo A Rossini; Dale L Greiner; Leonard D Shultz; Rita Bortell
Failure of alpha-galactosylceramide to prevent diabetes in virus-inducible models of type 1 diabetes in the rat.
In vivo (Athens, Greece) 2009;23(2):195-201.
2009: John P Mordes; Laura Cort; Elaine Norowski; Jean Leif; Jessica M Fuller; Ake Lernmark; Dale L Greiner; Elizabeth Blankenhorn
Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus.
Mammalian genome : official journal of the International Mammalian Genome Society 2009;20(3):162-9.
2009: Smita Jaiswal; Todd Pearson; Heather Friberg; Leonard D Shultz; Dale L Greiner; Alan L Rothman; Anuja Mathew
Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice.
PloS one 2009;4(10):e7251.
2009: Steven C Pino; Bryan O'Sullivan-Murphy; Erich A Lidstone; Chaoxing Yang; Kathryn L Lipson; Agata Jurczyk; Philip diIorio; Michael A Brehm; John P Mordes; Dale L Greiner; Aldo A Rossini; Rita Bortell
CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells.
PloS one 2009;4(5):e5468.
2009: Kenneth D Bishop; John E Harris; John P Mordes; Dale L Greiner; Aldo A Rossini; Michael P Czech; Nancy E Phillips
Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism.
Cellular immunology 2009;256(1-2):86-91.
2009: Julie Mangada; Todd Pearson; Michael A Brehm; Linda S Wicker; Laurence B Peterson; Leonard D Shultz; David V Serreze; Aldo A Rossini; Dale L Greiner
Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.
Diabetes 2009;58(1):165-73.
2008: David M Miller; Thomas B Thornley; Todd Pearson; Masahiro Yamazaki; Michael A Brehm; Aldo A Rossini; Dale L Greiner
TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance.
Annals of the New York Academy of Sciences 2008;1150():149-51.
2008: Rita Bortell; Steven C Pino; Dale L Greiner; Danny Zipris; Aldo A Rossini
Closing the circle between the bedside and the bench: Toll-like receptors in models of virally induced diabetes.
Annals of the New York Academy of Sciences 2008;1150():112-22.
2008: Marie King; Todd Pearson; Aldo A Rossini; Leonard D Shultz; Dale L Greiner
Humanized mice for the study of type 1 diabetes and beta cell function.
Annals of the New York Academy of Sciences 2008;1150():46-53.
2008: Steven C Pino; Bryan O'Sullivan-Murphy; Erich A Lidstone; Thomas B Thornley; Agata Jurczyk; Fumihiko Urano; Dale L Greiner; John P Mordes; Aldo A Rossini; Rita Bortell
Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response.
Cell stress & chaperones 2008;13(4):421-34.
2008: Todd Pearson; Leonard D Shultz; D Miller; M King; J Laning; W Fodor; A Cuthbert; Lisa M Burzenski; Bruce Gott; B Lyons; O Foreman; Aldo A Rossini; Dale L Greiner
Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment.
Clinical and experimental immunology 2008;154(2):270-84.
2008: Lisa J Giassi; Todd Pearson; Leonard D Shultz; Joseph Laning; Kristin Biber; Morey Kraus; Bruce A Woda; Madelyn R Schmidt; Robert T Woodland; Aldo A Rossini; Dale L Greiner
Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice.
Experimental biology and medicine (Maywood, N.J.) 2008;233(8):997-1012.
2008: Todd Pearson; Leonard D Shultz; J Lief; Lisa M Burzenski; Bruce Gott; T Chase; O Foreman; Aldo A Rossini; R Bottino; Massimo Trucco; Dale L Greiner
A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.
Diabetologia 2008;51(8):1449-56.
2008: Todd Pearson; Dale L Greiner; Leonard D Shultz
Creation of "humanized" mice to study human immunity.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2008;Chapter 15():Unit 15.21.
2008: Marie King; Todd Pearson; Leonard D Shultz; Jean Leif; Rita Bottino; Massimo Trucco; Mark A Atkinson; clive wasserfall; Kevan C Herold; Robert T Woodland; Madelyn R Schmidt; Bruce A Woda; Michael J Thompson; Aldo A Rossini; Dale L Greiner
A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.
Clinical immunology (Orlando, Fla.) 2008;126(3):303-14.
2008: David M Miller; Aldo A Rossini; Dale L Greiner
Role of innate immunity in transplantation tolerance.
Critical reviews in immunology 2008;28(5):403-39.
2008: David M Miller; Thomas B Thornley; Dale L Greiner; Aldo A Rossini
Viral infection: a potent barrier to transplantation tolerance.
Clinical & developmental immunology 2008;2008():742810.
2008: Madelyn R Schmidt; Michael C Appel; Lisa J Giassi; Dale L Greiner; Leonard D Shultz; Robert T Woodland
Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice.
PloS one 2008;3(9):e3192.
2008: Todd Pearson; Dale L Greiner; Leonard D Shultz
Humanized SCID mouse models for biomedical research.
Current topics in microbiology and immunology 2008;324():25-51.
2007: Thomas B Thornley; Nancy E Phillips; Britte C Beaudette-Zlatanova; Thomas G Markees; Kapil Bahl; Michael A Brehm; Leonard D Shultz; Evelyn A Kurt-Jones; John P Mordes; Raymond M Welsh; Aldo A Rossini; Dale L Greiner
Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):6620-9.
2007: M Yamazaki; Todd Pearson; Michael A Brehm; D M Miller; Julie Mangada; Thomas G Markees; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(7):1710-21.
2007: Elizabeth Blankenhorn; Cheryl DeScipio; Lucy Rodemich; Laura Cort; Jean Leif; Dale L Greiner; John P Mordes
Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVbeta4 as a candidate gene.
Annals of the New York Academy of Sciences 2007;1103():128-31.
2007: Aldo A Rossini; Dale L Greiner
Diabetes research in jeopardy: the extinction of clinical diabetes researchers.
Annals of the New York Academy of Sciences 2007;1103():33-44.
2007: Marie King; Todd Pearson; Leonard D Shultz; Jean Leif; Rita Bottino; Massimo Trucco; Mark Atkinson; clive wasserfall; Kevan Herold; John P Mordes; Aldo A Rossini; Dale L Greiner
Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity.
Annals of the New York Academy of Sciences 2007;1103():90-3.
2007: Leonard D Shultz; Todd Pearson; Marie King; Lisa Giassi; Lisa Carney; Bruce Gott; Bonnie Lyons; Aldo A Rossini; Dale L Greiner
Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research.
Annals of the New York Academy of Sciences 2007;1103():77-89.
2007: Leonard D Shultz; Fumihiko Ishikawa; Dale L Greiner
Humanized mice in translational biomedical research.
Nature reviews. Immunology 2007;7(2):118-30.
2007: Danny Zipris; Egil Lien; Anjali Nair; Jenny X Xie; Dale L Greiner; John P Mordes; Aldo A Rossini
TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(2):693-701.
2007: Michael A Brehm; Julie Mangada; Thomas G Markees; Todd Pearson; Keith A Daniels; Thomas B Thornley; Raymond M Welsh; Aldo A Rossini; Dale L Greiner
Rapid quantification of naive alloreactive T cells by TNF-alpha production and correlation with allograft rejection in mice.
Blood 2007;109(2):819-26.
2006: Jan-Luuk Hillebrands; Barbara J Whalen; Jeroen T J Visser; Jasper Koning; Kenneth D Bishop; Jean Leif; Jan Rozing; John P Mordes; Dale L Greiner; Aldo A Rossini
A regulatory CD4+ T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):7820-32.
2006: David V Serreze; Melissa A Osborne; Yi-Guang Chen; Harold D Chapman; Todd Pearson; Michael A Brehm; Dale L Greiner
Partial versus full allogeneic hemopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):6675-84.
2006: Alan R Morrison; Joel Moss; Linda A Stevens; James E Evans; Caitlin Farrell; Eric Merithew; David G Lambright; Dale L Greiner; John P Mordes; Aldo A Rossini; Rita Bortell
ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose).
The Journal of biological chemistry 2006;281(44):33363-72.
2006: Nancy E Phillips; Dale L Greiner; John P Mordes; Aldo A Rossini
Costimulatory blockade induces hyporesponsiveness in T cells that recognize alloantigen via indirect antigen presentation.
Transplantation 2006;82(8):1085-92.
2006: Hideyuki Masaki; Michael C Appel; Linda Leahy; Jean Leif; Linda Paquin; Leonard D Shultz; John P Mordes; Dale L Greiner; Aldo A Rossini
Anti-mouse CD154 antibody treatment facilitates generation of mixed xenogeneic rat hematopoietic chimerism, prevents wasting disease and prolongs xenograft survival in mice.
Xenotransplantation 2006;13(3):224-32.
2006: Britte C Beaudette-Zlatanova; Barbara J Whalen; Danny Zipris; Hideo Yagita; Jan Rozing; Herman Groen; C D Benjamin; T Hunig; Hemmo Drexhage; Mohammed Javeed I Ansari; Jean Leif; John P Mordes; Dale L Greiner; Mohamed H Sayegh; Aldo A Rossini
Costimulation and autoimmune diabetes in BB rats.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(5 Pt 1):894-902.
2006: Thomas B Thornley; Michael A Brehm; Thomas G Markees; Leonard D Shultz; John P Mordes; Raymond M Welsh; Aldo A Rossini; Dale L Greiner
TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1561-70.
2005: John P Mordes; Dennis L Guberski; Jean Leif; Bruce A Woda; Joan F Flanagan; Dale L Greiner; Edward Kislauskis; Rebecca Tirabassi
LEW.1WR1 rats develop autoimmune diabetes spontaneously and in response to environmental perturbation.
Diabetes 2005;54(9):2727-33.
2005: Leonard D Shultz; Bonnie L Lyons; Lisa M Burzenski; Bruce Gott; Xiaohua Chen; Stanley Chaleff; Malak Kotb; Stephen D Gillies; Marie King; Julie Mangada; Dale L Greiner; Rupert Handgretinger
Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):6477-89.
2005: Anja Jaeschke; Mercedes Rincón; Beth Doran; Judy Reilly; Donna Neuberg; Dale L Greiner; Leonard D Shultz; Aldo A Rossini; Richard A Flavell; Roger J Davis
Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(19):6931-5.
2005: Elizabeth Blankenhorn; Lucy Rodemich; Cristina Martin-Fernandez; Jean Leif; Dale L Greiner; John P Mordes
The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection.
Diabetes 2005;54(4):1233-7.
2005: Ethel J Gordon; Linda S Wicker; Laurence B Peterson; David V Serreze; Thomas G Markees; Leonard D Shultz; Aldo A Rossini; Dale L Greiner; John P Mordes
Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice.
Diabetes 2005;54(1):107-15.
2005: Danny Zipris; Egil Lien; Jenny X Xie; Dale L Greiner; John P Mordes; Aldo A Rossini
TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(1):131-42.
2004: Thomas G Markees; Todd Pearson; Amy Cuthbert; Andrea L Pearson; Leonard D Shultz; Jean Leif; Nancy E Phillips; John P Mordes; Dale L Greiner; Aldo A Rossini
Evaluation of donor-specific transfusion sources: unique failure of bone marrow cells to induce prolonged skin allograft survival with anti-CD154 monoclonal antibody.
Transplantation 2004;78(11):1601-8.
2004: John E Harris; Kenneth D Bishop; Nancy E Phillips; John P Mordes; Dale L Greiner; Aldo A Rossini; Michael P Czech
Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(12):7331-8.
2004: Scott J Banuelos; Thomas G Markees; Nancy E Phillips; Michael C Appel; Amy Cuthbert; Jean Leif; John P Mordes; Leonard D Shultz; Aldo A Rossini; Dale L Greiner
Regulation of skin and islet allograft survival in mice treated with costimulation blockade is mediated by different CD4+ cell subsets and different mechanisms.
Transplantation 2004;78(5):660-7.
2004: Scott J Banuelos; Leonard D Shultz; Dale L Greiner; Lisa M Burzenski; Bruce Gott; Bonnie L Lyons; Aldo A Rossini; Michael C Appel
Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice.
Clinical immunology (Orlando, Fla.) 2004;112(3):273-83.
2004: Todd Pearson; Peter Weiser; Thomas G Markees; David V Serreze; Linda S Wicker; Laurence B Peterson; Anne-Marie Cumisky; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.
Diabetes 2004;53(8):1972-8.
2004: Michael C Appel; Scott J Banuelos; Dale L Greiner; Leonard D Shultz; John P Mordes; Aldo A Rossini
Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibody.
Transplantation 2004;77(9):1341-9.
2004: Derrick J Todd; Eric M Forsberg; Dale L Greiner; John P Mordes; Aldo A Rossini; Rita Bortell
Deficiencies in gut NK cell number and function precede diabetes onset in BB rats.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(9):5356-62.
2004: John P Mordes; Rita Bortell; Elizabeth Blankenhorn; Aldo A Rossini; Dale L Greiner
Rat models of type 1 diabetes: genetics, environment, and autoimmunity.
ILAR journal / National Research Council, Institute of Laboratory Animal Resources 2004;45(3):278-91.
2003: Todd Pearson; Thomas G Markees; David V Serreze; Melissa A Pierce; Linda S Wicker; Laurence B Peterson; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms?
Annals of the New York Academy of Sciences 2003;1005():148-56.
2003: PE Bigazzi; LL Kosuda; Michael O Hannigan; Barbara J Whalen; Dale L Greiner
Lack of graft-versus-host-like pathology in mercury-induced autoimmunity of Brown Norway rats.
Clinical immunology (Orlando, Fla.) 2003;109(2):229-37.
2003: Leonard D Shultz; Scott J Banuelos; Bonnie Lyons; Rebecca Samuels; Lisa M Burzenski; Bruce Gott; Pamela Lang; Jean Leif; Michael C Appel; Aldo Rossini; Dale L Greiner
NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment.
Transplantation 2003;76(7):1036-42.
2003: Nicole A Turgeon; Scott J Banuelos; Leonard D Shultz; Bonnie L Lyons; Neal Iwakoshi; Dale L Greiner; John P Mordes; Aldo A Rossini; Michael C Appel
Alloimmune injury and rejection of human skin grafts on human peripheral blood lymphocyte-reconstituted non-obese diabetic severe combined immunodeficient beta2-microglobulin-null mice.
Experimental biology and medicine (Maywood, N.J.) 2003;228(9):1096-104.
2003: Malini Pandarpurkar; Leanne Wilson-Fritch; Silvia Corvera; Helle Markholst; Lars Hornum; Dale L Greiner; John P Mordes; Aldo A Rossini; Rita Bortell
Ian4 is required for mitochondrial integrity and T cell survival.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(18):10382-7.
2003: Todd Pearson; Thomas G Markees; David V Serreze; Melissa A Pierce; Linda S Wicker; Laurence B Peterson; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice.
Reviews in endocrine & metabolic disorders 2003;4(3):255-61.
2003: Edward Seung; John P Mordes; Aldo A Rossini; Dale L Greiner
Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning.
The Journal of clinical investigation 2003;112(5):795-808.
2003: Edward Seung; John P Mordes; Dale L Greiner; Aldo A Rossini
Induction of tolerance for islet transplantation for type 1 diabetes.
Current diabetes reports 2003;3(4):329-35.
2003: Todd Pearson; Thomas G Markees; David V Serreze; Melissa A Pierce; Michele P Marron; Linda S Wicker; Laurence B Peterson; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(1):185-95.
2003: Leonard D Shultz; Scott J Banuelos; Jean Leif; Michael C Appel; Melody Cunningham; Karen K Ballen; Lisa M Burzenski; Dale L Greiner
Regulation of human short-term repopulating cell (STRC) engraftment in NOD/SCID mice by host CD122+ cells.
Experimental hematology 2003;31(6):551-8.
2003: Michael A Brehm; Thomas G Markees; Keith A Daniels; Dale L Greiner; Aldo A Rossini; Raymond M Welsh
Direct visualization of cross-reactive effector and memory allo-specific CD8 T cells generated in response to viral infections.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(8):4077-86.
2003: Danny Zipris; Jan-Luuk Hillebrands; Raymond M Welsh; Jan Rozing; Jenny X Xie; John P Mordes; Dale L Greiner; Aldo A Rossini
Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(7):3592-602.
2003: Nancy E Phillips; Thomas G Markees; John P Mordes; Dale L Greiner; Aldo A Rossini
Blockade of CD40-mediated signaling is sufficient for inducing islet but not skin transplantation tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):3015-23.
2003: Barbara J Whalen; Jan Marounek; John P Mordes; Aldo A Rossini; Dale L Greiner
Type 1 cytokines polarize thymocytes during T cell development in adult thymus organ cultures.
Journal of autoimmunity 2003;20(1):27-42.
2003: Todd Pearson; Thomas G Markees; Linda S Wicker; David V Serreze; Laurence B Peterson; John P Mordes; Aldo A Rossini; Dale L Greiner
NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction.
Diabetes 2003;52(2):321-6.
2002: John P Mordes; Jean Leif; Stephen Novak; Cheryl DeScipio; Dale L Greiner; Elizabeth Blankenhorn
The iddm4 locus segregates with diabetes susceptibility in congenic WF.iddm4 rats.
Diabetes 2002;51(11):3254-62.
2002: Daron Forman; Raymond M Welsh; Thomas G Markees; Bruce A Woda; John P Mordes; Aldo A Rossini; Dale L Greiner
Viral abrogation of stem cell transplantation tolerance causes graft rejection and host death by different mechanisms.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6047-56.
2002: Sherri W Christianson; Dale L Greiner; Dominick DeLuca; Jean Leif; Nancy E Phillips; Sandra M Hayes; Shin-Ichi Hayashi; Melissa J Joliat; Bonnie L Lyons; Leonard D Shultz
T cell developmental defects in 'viable motheaten' mice deficient in SHP-1 protein-tyrosine phosphatase. Developmental defects are corrected in vitro in the presence of normal hematopoietic-origin stromal cells and in vivo by exogenous IL-7.
Journal of autoimmunity 2002;18(2):119-30.
2001: Neal Iwakoshi; Thomas G Markees; Nicole A Turgeon; Thomas B Thornley; Amy Cuthbert; Jean Leif; Nancy E Phillips; John P Mordes; Dale L Greiner; Aldo A Rossini
Skin allograft maintenance in a new synchimeric model system of tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(11):6623-30.
2001: Aldo A Rossini; John P Mordes; Dale L Greiner; Jeffrey S Stoff
Islet cell transplantation tolerance.
Transplantation 2001;72(8 Suppl):S43-6.
2001: D J Todd; Dale L Greiner; Aldo A Rossini; John P Mordes; Rita Bortell
An atypical population of NK cells that spontaneously secrete IFN-gamma and IL-4 is present in the intraepithelial lymphoid compartment of the rat.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(7):3600-9.
2001: Rita Bortell; Joel Moss; R C McKenna; M R Rigby; D Niedzwiecki; Linda A Stevens; W A Patton; John P Mordes; Dale L Greiner; Aldo A Rossini
Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):2049-59.
2001: Dale L Greiner; Aldo A Rossini; J P Mordes
Translating data from animal models into methods for preventing human autoimmune diabetes mellitus: caveat emptor and primum non nocere.
Clinical immunology (Orlando, Fla.) 2001;100(2):134-43.
2001: R Bortel; D J Waite; Barbara J Whalen; D Todd; Jean Leif; EA Lesma; Joel Moss; John P Mordes; Aldo A Rossini; Dale L Greiner
Levels of Art2+ cells but not soluble Art2 protein correlate with expression of autoimmune diabetes in the BB rat.
Autoimmunity 2001;33(3):199-211.
2001: Barbara J Whalen; Jan Marounek; Peter Weiser; M C Appel; Dale L Greiner; John P Mordes; Aldo A Rossini
BB rat thymocytes cultured in the presence of islets lose their ability to transfer autoimmune diabetes.
Diabetes 2001;50(5):972-9.
2001: Danny Zipris; Jean Leif; Dominick DeLuca; M Y Lin; John P Mordes; Aldo A Rossini; Dale L Greiner; Barbara J Whalen
Fetal thymi from diabetes-prone but not diabetes-resistant BB/Wor rats fail to generate mature ART2+ T-cells in organ culture.
Cellular and molecular biology (Noisy-le-Grand, France) 2001;47(1):65-74.
2001: Ethel J Gordon; Bruce A Woda; Leonard D Shultz; Aldo A Rossini; Dale L Greiner; John P Mordes
Rat xenograft survival in mice treated with donor-specific transfusion and anti-CD154 antibody is enhanced by elimination of host CD4+ cells.
Transplantation 2001;71(2):319-27.
2000: Nicole A Turgeon; Neal Iwakoshi; Nancy E Phillips; William C Meyers; Raymond M Welsh; Dale L Greiner; John P Mordes; Aldo A Rossini
Viral infection abrogates CD8(+) T-cell deletion induced by costimulation blockade.
The Journal of surgical research 2000;93(1):63-9.
2000: EJ Wagar; M A Cromwell; Leonard D Shultz; Bruce A Woda; John L Sullivan; R M Hesselton; Dale L Greiner
Regulation of human cell engraftment and development of EBV-related lymphoproliferative disorders in Hu-PBL-scid mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):518-27.
2000: Edward Seung; Neal Iwakoshi; Bruce A Woda; Thomas G Markees; John P Mordes; Aldo A Rossini; Dale L Greiner
Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice.
Blood 2000;95(6):2175-82.
2000: Leonard D Shultz; P A Lang; Sherri W Christianson; Bruce Gott; Bonnie Lyons; S Umeda; Edward H Leiter; Ruth Hesselton; EJ Wagar; Jean Leif; Orit Kollet; Tsvee Lapidot; Dale L Greiner
NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(5):2496-507.
2000: Raymond M Welsh; Thomas G Markees; Bruce A Woda; Keith A Daniels; Michael A Brehm; John P Mordes; Dale L Greiner; Aldo A Rossini
Virus-induced abrogation of transplantation tolerance induced by donor-specific transfusion and anti-CD154 antibody.
Journal of virology 2000;74(5):2210-8.
2000: Neal Iwakoshi; John P Mordes; Thomas G Markees; Nancy E Phillips; Aldo A Rossini; Dale L Greiner
Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(1):512-21.
1999: A M Martin; M N Maxson; Jean Leif; John P Mordes; Dale L Greiner; Elizabeth Blankenhorn
Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4.
Diabetes 1999;48(11):2138-44.
1999: Thomas G Markees; David V Serreze; Nancy E Phillips; C H Sorli; Ethel J Gordon; Leonard D Shultz; RJ Noelle; Bruce A Woda; Dale L Greiner; John P Mordes; Aldo A Rossini
NOD mice have a generalized defect in their response to transplantation tolerance induction.
Diabetes 1999;48(5):967-74.
1999: Barbara J Whalen; L C Love; John P Mordes; Aldo A Rossini; Dale L Greiner
Intravital dye-labeled diabetogenic rat T cells retain dye, home to the pancreas, and induce diabetes.
Transplantation proceedings 1999;31(3):1611-4.
1999: D Todd; A J Singh; Dale L Greiner; John P Mordes; Aldo A Rossini; Rita Bortell
A new isolation method for rat intraepithelial lymphocytes.
Journal of immunological methods 1999;224(1-2):111-27.
1999: J E Buhlmann; Mercedes Gonzalez; B Ginther; Angela Panoskaltsis-Mortari; Bruce R Blazar; Dale L Greiner; A A Rossini; R Flavell; Randolph J Noelle
Cutting edge: sustained expansion of CD8+ T cells requires CD154 expression by Th cells in acute graft versus host disease.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4373-6.
1999: Barbara J Whalen; Peter Weiser; Jan Marounek; Aldo A Rossini; John P Mordes; Dale L Greiner
Recapitulation of normal and abnormal BioBreeding rat T cell development in adult thymus organ culture.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(7):4003-12.
1999: Rita Bortell; T Kanaitsuka; Linda A Stevens; Joel Moss; John P Mordes; Aldo A Rossini; Dale L Greiner
The RT6 (Art2) family of ADP-ribosyltransferases in rat and mouse.
Molecular and cellular biochemistry 1999;193(1-2):61-8.
1999: Thomas G Markees; Nancy E Phillips; Ethel J Gordon; RJ Noelle; C Maliszewski; John P Mordes; Dale L Greiner; Aldo A Rossini
Prolonged skin allograft survival in mice treated with Flt3-ligand-induced dendritic cells and anti-CD154 monoclonal antibody.
Transplantation proceedings 1999;31(1-2):884-5.
1999: Aldo A Rossini; John P Mordes; Thomas G Markees; Nancy E Phillips; Ethel J Gordon; Dale L Greiner
Induction of islet transplantation tolerance using donor specific transfusion and anti-CD154 monoclonal antibody.
Transplantation proceedings 1999;31(1-2):629-32.
1999: Neal Iwakoshi; Dale L Greiner; Aldo A Rossini; John P Mordes
Diabetes prone BB rats are severely deficient in natural killer T cells.
Autoimmunity 1999;31(1):1-14.
1999: Aldo A Rossini; Dale L Greiner; John P Mordes
Induction of immunologic tolerance for transplantation.
Physiological reviews 1999;79(1):99-141.
1999: A M Martin; Elizabeth Blankenhorn; M N Maxson; M Zhao; Jean Leif; John P Mordes; Dale L Greiner
Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat.
Diabetes 1999;48(1):50-8.
1998: Thomas G Markees; N Phillips; E Gordon; RJ Noelle; John P Mordes; Dale L Greiner; Aldo A Rossini
Improved skin allograft tolerance induced by treatment with donor splenocytes and an extended course of anti-CD154 monoclonal antibody.
Transplantation proceedings 1998;30(5):2444-6.
1998: Ethel J Gordon; Thomas G Markees; Nancy E Phillips; RJ Noelle; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Prolonged survival of rat islet and skin xenografts in mice treated with donor splenocytes and anti-CD154 monoclonal antibody.
Diabetes 1998;47(8):1199-206.
1998: Neal Iwakoshi; Irving Goldschneider; F Tausche; John P Mordes; Aldo A Rossini; Dale L Greiner
High frequency apoptosis of recent thymic emigrants in the liver of lymphopenic diabetes-prone BioBreeding rats.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(12):5838-50.
1998: Thomas G Markees; Nancy E Phillips; Ethel J Gordon; RJ Noelle; Leonard D Shultz; John P Mordes; Dale L Greiner; Aldo A Rossini
Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4.
The Journal of clinical investigation 1998;101(11):2446-55.
1998: LL Kosuda; Barbara J Whalen; Dale L Greiner; PE Bigazzi
Mercury-induced autoimmunity in Brown Norway rats: kinetics of changes in RT6+ T lymphocytes correlated with IgG isotypes of circulating autoantibodies to laminin 1.
Toxicology 1998;125(2-3):215-31.
1998: Dale L Greiner; Ruth Hesselton; Leonard D Shultz
SCID mouse models of human stem cell engraftment.
Stem cells (Dayton, Ohio) 1998;16(3):166-77.
1998: T M Foy; M McIlraith; SR Masters; J J Dunn; A A Rossini; Leonard D Shultz; Ruth Hesselton; EJ Wagar; P E Lipsky; Randolph J Noelle; Dale L Greiner
Blockade of CD40-CD154 interferes with human T cell engraftment in scid mice.
Cell transplantation 1998;7(1):25-35.
1997: T Kanaitsuka; Rita Bortell; Linda A Stevens; Joel Moss; DF Sardinha; Thiruchandurai V Rajan; Danny Zipris; John P Mordes; Dale L Greiner; Aldo A Rossini
Expression in BALB/c and C57BL/6 mice of Rt6-1 and Rt6-2 ADP-ribosyltransferases that differ in enzymatic activity: C57BL/6 Rt6-1 is a natural transferase knockout.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):2741-9.
1997: Thomas G Markees; Nancy E Phillips; RJ Noelle; Leonard D Shultz; John P Mordes; Dale L Greiner; Aldo A Rossini
Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand.
Transplantation 1997;64(2):329-35.
1997: S Malkani; DJ Nompleggi; J W Hansen; Dale L Greiner; John P Mordes; Aldo A Rossini
Dietary cow's milk protein does not alter the frequency of diabetes in the BB rat.
Diabetes 1997;46(7):1133-40.
1997: Barbara J Whalen; J Doukas; John P Mordes; Aldo A Rossini; Dale L Greiner
Induction of insulin-dependent diabetes mellitus in PVG.RT1u rats.
Transplantation proceedings 1997;29(3):1684-5.
1997: Sherri W Christianson; Dale L Greiner; Ruth Hesselton; Jean Leif; EJ Wagar; I B Schweitzer; T V Rajan; Bruce Gott; Derry C Roopenian; Leonard D Shultz
Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(8):3578-86.
1997: Joel Moss; Linda A Stevens; Eleanor Cavanaugh; Ian Okazaki; Rita Bortell; T Kanaitsuka; John P Mordes; Dale L Greiner; Aldo A Rossini
Characterization of mouse Rt6.1 NAD:arginine ADP-ribosyltransferase.
The Journal of biological chemistry 1997;272(7):4342-6.
1997: LL Kosuda; Dale L Greiner; PE Bigazzi
Effects of HgCl2 on the expression of autoimmune responses and disease in diabetes-prone (DP) BB rats.
Autoimmunity 1997;26(3):173-87.
1997: Dale L Greiner; S Malkani; T Kanaitsuka; Rita Bortell; J Doukas; M Rigby; Barbara J Whalen; Linda A Stevens; Joel Moss; John P Mordes; Aldo A Rossini
The T cell marker RT6 in a rat model of autoimmune diabetes.
Advances in experimental medicine and biology 1997;419():209-16.
1996: M R Rigby; Rita Bortell; Dale L Greiner; M P Czech; J K Klarlund; John P Mordes; Aldo A Rossini
The rat T-cell surface protein RT6 is associated with src family tyrosine kinases and generates an activation signal.
Diabetes 1996;45(10):1419-26.
1996: Sherri W Christianson; Dale L Greiner; I B Schweitzer; Bruce Gott; G L Beamer; P A Schweitzer; R M Hesselton; L D Shultz
Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice.
Cellular immunology 1996;171(2):186-99.
1996: John P Mordes; Rita Bortell; J Doukas; M Rigby; Barbara J Whalen; D Zipris; Dale L Greiner; Aldo A Rossini
The BB/Wor rat and the balance hypothesis of autoimmunity.
Diabetes/metabolism reviews 1996;12(2):103-9.
1996: D J Waite; M C Appel; E S Handler; John P Mordes; Aldo A Rossini; Dale L Greiner
Ontogeny and immunohistochemical localization of thymus-dependent and thymus-independent RT6+ cells in the rat.
The American journal of pathology 1996;148(6):2043-56.
1996: M R Rigby; Rita Bortell; Linda A Stevens; Joel Moss; T Kanaitsuka; H Shigeta; John P Mordes; Dale L Greiner; Aldo A Rossini
Rat RT6.2 and mouse Rt6 locus 1 are NAD+: arginine ADP ribosyltransferases with auto-ADP ribosylation activity.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(11):4259-65.
1996: Thiruchandurai V Rajan; Dale L Greiner; J A Yates; L D Shultz
Growth of the human filarial parasite Brugia malayi in mice lacking major histocompatibility complex class II antigen expression.
Acta tropica 1996;61(3):267-71.
1996: Thomas G Markees; M C Appel; RJ Noelle; John P Mordes; Dale L Greiner; Aldo A Rossini
Tolerance to islet xenografts induced by dual manipulation of antigen presentation and co-stimulation.
Transplantation proceedings 1996;28(2):814-5.
1996: John P Mordes; B Schirf; D Roipko; Dale L Greiner; H Weiner; P Nelson; Aldo A Rossini
Oral insulin does not prevent insulin-dependent diabetes mellitus in BB rats.
Annals of the New York Academy of Sciences 1996;778():418-21.
1996: P A Lowry; L D Shultz; Dale L Greiner; R M Hesselton; E L Kittler; CY Tiarks; S S Rao; Judy Reilly; J H Leif; H Ramshaw; F Marc Stewart; Peter J Quesenberry
Improved engraftment of human cord blood stem cells in NOD/LtSz-scid/scid mice after irradiation or multiple-day injections into unirradiated recipients.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 1996;2(1):15-23.
1996: D Zipris; Dale L Greiner; S Malkani; Barbara J Whalen; John P Mordes; Aldo A Rossini
Cytokine gene expression in islets and thyroids of BB rats. IFN-gamma and IL-12p40 mRNA increase with age in both diabetic and insulin-treated nondiabetic BB rats.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(3):1315-21.
1996: H H Zadeh; Dale L Greiner; D Y Wu; F Tausche; Irving Goldschneider
Abnormalities in the export and fate of recent thymic emigrants in diabetes-prone BB/W rats.
Autoimmunity 1996;24(1):35-46.
1996: L L Kosuda; M O Hannigan; PE Bigazzi; J H Leif; Dale L Greiner
Thymus atrophy and changes in thymocyte subpopulations of BN rats with mercury-induced renal autoimmune disease.
Autoimmunity 1996;23(2):77-89.
1996: Dale L Greiner; L D Shultz; Dominick DeLuca; J H Leif; Sherri W Christianson; R M Hesselton
HIV-1 infectivity of human T cells in a human/murine chimeric fetal thymic organ culture system.
In vivo (Athens, Greece) 1996;10(1):33-7.
1996: Aldo A Rossini; David Parker; Nancy E Phillips; F H Durie; RJ Noelle; John P Mordes; Dale L Greiner
Induction of immunological tolerance to islet allografts.
Cell transplantation 1996;5(1):49-52.
1995: David V Serreze; Edward H Leiter; M S Hanson; Sherri W Christianson; L D Shultz; R M Hesselton; Dale L Greiner
Emv30null NOD-scid mice. An improved host for adoptive transfer of autoimmune diabetes and growth of human lymphohematopoietic cells.
Diabetes 1995;44(12):1392-8.
1995: David Parker; Dale L Greiner; Nancy E Phillips; M C Appel; A W Steele; F H Durie; RJ Noelle; John P Mordes; Aldo A Rossini
Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9560-4.
1995: R M Hesselton; Dale L Greiner; John P Mordes; T V Rajan; John L Sullivan; L D Shultz
High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice.
The Journal of infectious diseases 1995;172(4):974-82.
1995: Barbara J Whalen; Aldo A Rossini; John P Mordes; Dale L Greiner
DR-BB rat thymus contains thymocyte populations predisposed to autoreactivity.
Diabetes 1995;44(8):963-7.
1995: Thiruchandurai V Rajan; L D Shultz; J Yates; Dale L Greiner
B lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi.
The Journal of parasitology 1995;81(3):490-3.
1995: Dale L Greiner; L D Shultz; J Yates; M C Appel; G Perdrizet; R M Hesselton; I Schweitzer; W G Beamer; Kathryn L Shultz; S C Pelsue
Improved engraftment of human spleen cells in NOD/LtSz-scid/scid mice as compared with C.B-17-scid/scid mice.
The American journal of pathology 1995;146(4):888-902.
1995: L D Shultz; P A Schweitzer; Sherri W Christianson; Bruce Gott; I B Schweitzer; BJ Tennent; S McKenna; L Mobraaten; T V Rajan; Dale L Greiner
Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(1):180-91.
1995: Aldo A Rossini; E S Handler; John P Mordes; Dale L Greiner
Human autoimmune diabetes mellitus: lessons from BB rats and NOD mice--Caveat emptor.
Clinical immunology and immunopathology 1995;74(1):2-9.
1994: J Doukas; John P Mordes; C Swymer; D Niedzwiecki; R Mason; J Rozing; Aldo A Rossini; Dale L Greiner
Thymic epithelial defects and predisposition to autoimmune disease in BB rats.
The American journal of pathology 1994;145(6):1517-25.
1994: Barbara J Whalen; Dale L Greiner; John P Mordes; Aldo A Rossini
Adoptive transfer of autoimmune diabetes mellitus to athymic rats: synergy of CD4+ and CD8+ T cells and prevention by RT6+ T cells.
Journal of autoimmunity 1994;7(6):819-31.
1994: Thiruchandurai V Rajan; J M Bailis; J A Yates; L D Shultz; Dale L Greiner; F K Nelson
Maternal influence on susceptibility of offspring to Brugia malayi infection in a murine model of filariasis.
Acta tropica 1994;58(3-4):283-9.
1994: S D McKenna; E S Medlock; Dale L Greiner; Irving Goldschneider
A selective culture system for generating terminal deoxynucleotidyl transferase-positive lymphoid precursor cells in vitro. IV. Properties and developmental relationships of the lymphoid cells in the adherent and nonadherent compartments of the culture.
Experimental hematology 1994;22(12):1164-70.
1994: L L Kosuda; H Hosseinzadeh; Dale L Greiner; PE Bigazzi
Role of RT6+ T lymphocytes in mercury-induced renal autoimmunity: experimental manipulations of "susceptible" and "resistant" rats.
Journal of toxicology and environmental health 1994;42(3):303-21.
1994: Thiruchandurai V Rajan; F K Nelson; N Killeen; L D Shultz; J A Yates; J M Bailis; Dan R Littman; Dale L Greiner
CD4+ T-lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi.
Experimental parasitology 1994;78(4):352-60.
1994: L L Kosuda; Dale L Greiner; PE Bigazzi
Mercury-induced renal autoimmunity in BN-->LEW.1N chimeric rats.
Cellular immunology 1994;155(1):77-94.
1994: Thiruchandurai V Rajan; F K Nelson; L D Shultz; Kathryn L Shultz; W G Beamer; J Yates; Dale L Greiner
Influence of gonadal steroids on susceptibility to Brugia malayi in scid mice.
Acta tropica 1994;56(4):307-14.
1994: R Battan; John P Mordes; S Abreau; Dale L Greiner; E S Handler; Aldo A Rossini
Evidence that intrathymic islet transplantation does not prevent diabetes or subsequent islet graft destruction in RT6-depleted, diabetes-resistant BioBreeding/Worcester rats.
Transplantation 1994;57(5):731-6.
1994: I C Gerling; H Friedman; Dale L Greiner; L D Shultz; Edward H Leiter
Multiple low-dose streptozocin-induced diabetes in NOD-scid/scid mice in the absence of functional lymphocytes.
Diabetes 1994;43(3):433-40.
1994: S M Hayes; L D Shultz; Dale L Greiner
Localization of prothymocytes from wild-type and viable motheaten mice following intravenous injection into irradiated adoptive recipients.
Cellular immunology 1994;153(2):344-55.
1993: D J Waite; E S Handler; John P Mordes; Aldo A Rossini; Dale L Greiner
The RT6 rat lymphocyte alloantigen circulates in soluble form.
Cellular immunology 1993;152(1):82-95.
1993: L L Kosuda; Dale L Greiner; PE Bigazzi
Mercury-induced renal autoimmunity: changes in RT6+ T-lymphocytes of susceptible and resistant rats.
Environmental health perspectives 1993;101(2):178-85.
1993: T A Binder; Dale L Greiner; M Grunnet; Irving Goldschneider
Relative susceptibility of SJL/J and B10.S mice to experimental allergic encephalomyelitis (EAE) is determined by the ability of prethymic cells in bone marrow to develop into EAE effector T cells.
Journal of neuroimmunology 1993;42(1):23-32.
1992: Thiruchandurai V Rajan; F K Nelson; L D Shultz; Beverly H Koller; Dale L Greiner
CD8+ T lymphocytes are not required for murine resistance to human filarial parasites.
The Journal of parasitology 1992;78(4):744-6.
1992: S M Hayes; Dale L Greiner
Evidence for elevated prothymocyte activity in the bone marrow of New Zealand Black (NZB) mice. Elevated prothymocyte activity in NZB mice.
Thymus 1992;19(3):157-72.
1992: Dale L Greiner; T V Rajan; L D Shultz
Animal models for immunodeficiency diseases.
Immunology today 1992;13(4):116-7.
1992: Thiruchandurai V Rajan; F K Nelson; E Cupp; L D Schultz; Dale L Greiner
Survival of Onchocerca volvulus in nodules implanted in immunodeficient rodents.
The Journal of parasitology 1992;78(1):160-3.
1992: S M Hayes; L D Shultz; Dale L Greiner
Thymic involution in viable motheaten (me(v)) mice is associated with a loss of intrathymic precursor activity.
Developmental immunology 1992;2(3):191-205.
1992: T V Rajan; L D Shultz; Dale L Greiner
Lack of peripherally induced tolerance to established skin allografts in immunologically reconstituted scid mice.
Developmental immunology 1992;3(1):45-50.
1991: Y Kitagawa; Dale L Greiner; C W Reynolds; J R Ortaldo; R Toccafondi; E S Handler; P H van der Meide; John P Mordes; Aldo A Rossini
Islet cells but not thyrocytes are susceptible to lysis by NK cells.
Journal of autoimmunity 1991;4(5):703-16.
1991: Dale L Greiner; L D Shultz; A A Rossini; John P Mordes; E S Handler; Thiruchandurai V Rajan
Recapitulation of normal and abnormal BB rat immune system development in scid mouse/rat lymphohemopoietic chimeras.
The Journal of clinical investigation 1991;88(2):717-9.
1991: L S Cutler; Dale L Greiner; D Rozenski
Experimental autoallergic sialadenitis in the LEW rat. II. Target antigens are associated with cell surface and intracellular particulate fractions derived from the submandibular gland.
Cellular immunology 1991;135(2):346-53.
1991: L S Cutler; D Rozenski; J Coolens; J Rozing; M Angelillo; A L Wayne; K M Fitzgerald; Dale L Greiner
Experimental autoallergic sialadenitis in the LEW rat. I. Parameters of disease induction.
Cellular immunology 1991;135(2):335-45.
1991: Dale L Greiner; M Angelillo; A L Wayne; K M Fitzgerald; D Rozenski; L S Cutler
Experimental autoallergic sialadenitis in the LEW rat. III. Role of CD4+ T cells in EAS induction.
Cellular immunology 1991;135(2):354-9.
1991: L L Kosuda; A Wayne; M Nahounou; Dale L Greiner; PE Bigazzi
Reduction of the RT6.2+ subset of T lymphocytes in brown Norway rats with mercury-induced renal autoimmunity.
Cellular immunology 1991;135(1):154-67.
1991: P A Gottlieb; E S Handler; M C Appel; Dale L Greiner; John P Mordes; Aldo A Rossini
Insulin treatment prevents diabetes mellitus but not thyroiditis in RT6-depleted diabetes resistant BB/Wor rats.
Diabetologia 1991;34(5):296-300.
1991: Bruce A Woda; E S Handler; Dale L Greiner; C Reynolds; John P Mordes; Aldo A Rossini
T-lymphocyte requirement for diabetes in RT6-depleted diabetes-resistant BB rats.
Diabetes 1991;40(4):423-8.
1991: F K Nelson; Dale L Greiner; L D Shultz; Thiruchandurai V Rajan
The immunodeficient scid mouse as a model for human lymphatic filariasis.
The Journal of experimental medicine 1991;173(3):659-63.
1991: V A Thomas; Bruce A Woda; E S Handler; Dale L Greiner; John P Mordes; Aldo A Rossini
Altered expression of diabetes in BB/Wor rats by exposure to viral pathogens.
Diabetes 1991;40(2):255-8.
1991: Aldo A Rossini; E S Handler; Dale L Greiner; John P Mordes
Insulin dependent diabetes mellitus hypothesis of autoimmunity.
Autoimmunity 1991;8(3):221-35.
1991: C F Mojcik; Dale L Greiner; Irving Goldschneider
Characterization of RT6-bearing rat lymphocytes. II. Developmental relationships of RT6- and RT6+ T cells.
Developmental immunology 1991;1(3):191-201.
1990: U McKeever; John P Mordes; Dale L Greiner; M C Appel; J Rozing; E S Handler; Aldo A Rossini
Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(19):7618-22.
1990: L Crisá; Dale L Greiner; John P Mordes; R G MacDonald; E S Handler; M P Czech; Aldo A Rossini
Biochemical studies of RT6 alloantigens in BB/Wor and normal rats. Evidence for intact unexpressed RT6a structural gene in diabetes-prone BB rats.
Diabetes 1990;39(10):1279-88.
1990: N Nakamura; Bruce A Woda; A Tafuri; Dale L Greiner; C W Reynolds; J Ortaldo; W Chick; E S Handler; John P Mordes; Aldo A Rossini
Intrinsic cytotoxicity of natural killer cells to pancreatic islets in vitro.
Diabetes 1990;39(7):836-43.
1989: Aldo A Rossini; John P Mordes; Dale L Greiner
The pathogenesis of autoimmune diabetes mellitus.
Current opinion in immunology 1989;2(4):598-603.
1989: D Burstein; John P Mordes; Dale L Greiner; D Stein; N Nakamura; E S Handler; Aldo A Rossini
Prevention of diabetes in BB/Wor rat by single transfusion of spleen cells. Parameters that affect degree of protection.
Diabetes 1989;38(1):24-30.
1989: E S Handler; John P Mordes; U McKeever; N Nakamura; J Bernhard; Dale L Greiner; Aldo A Rossini
Effects of irradiation on diabetes in the BB/Wor rat.
Autoimmunity 1989;4(1-2):21-30.
1988: M Angelillo; Dale L Greiner; John P Mordes; E S Handler; N Nakamura; U McKeever; A Rossini
Absence of RT6+ T cells in diabetes-prone biobreeding/Worcester rats is due to genetic and cell developmental defects.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(12):4146-51.
1988: C F Mojcik; Dale L Greiner; E S Medlock; K L Komschlies; Irving Goldschneider
Characterization of RT6 bearing rat lymphocytes. I. Ontogeny of the RT6+ subset.
Cellular immunology 1988;114(2):336-46.
1988: K Nakano; John P Mordes; E S Handler; Dale L Greiner; Aldo A Rossini
Role of host immune system in BB/Wor rat. Predisposition to diabetes resides in bone marrow.
Diabetes 1988;37(5):520-5.
1988: S V Hunt; E S Medlock; Dale L Greiner; Irving Goldschneider; D Opstelten
Rat immunoglobulin genes have comparable patterns of JH rearrangement in normal peripheral B cells and in pre-B and cultured TdT+ cells from bone marrow.
Advances in experimental medicine and biology 1988;237():63-8.
1988: Dale L Greiner; M Angelillo; John P Mordes; E S Handler; C F Mojcik; N Nakamura; A A Rossini
Regulatory T cell control of autoimmune destruction of beta cells in the BB rat.
Advances in experimental medicine and biology 1988;246():379-85.
1987: K L Komschlies; Dale L Greiner; L Shultz; Irving Goldschneider
Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. III. Normal mouse bone marrow cells enable mev/mev prothymocytes to generate thymocytes after intravenous transfer.
The Journal of experimental medicine 1987;166(4):1162-7.
1987: C F Mojcik; Dale L Greiner; Irving Goldschneider; D M Lubaroff
Monoclonal antibodies to RT7 and LCA antigens in the rat: cell distribution and segregation analysis.
Hybridoma 1987;6(5):531-43.
1987: Dale L Greiner; John P Mordes; E S Handler; M Angelillo; N Nakamura; A A Rossini
Depletion of RT6.1+ T lymphocytes induces diabetes in resistant biobreeding/Worcester (BB/W) rats.
The Journal of experimental medicine 1987;166(2):461-75.
1987: E S Medlock; Irving Goldschneider; Dale L Greiner; L Shultz
Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. II. Description of a microenvironmental defect for the generation of terminal deoxynucleotidyltransferase-positive bone marrow cells in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(11):3590-7.
1987: Dale L Greiner; John P Mordes; E S Handler; N Nakamura; M Angelillo; A A Rossini
Prothymocyte development in diabetes-prone BB rats: description of a defect that predisposes to immune abnormalities.
Transplantation proceedings 1987;19(1 Pt 2):976-8.
1986: Dale L Greiner; Irving Goldschneider; K L Komschlies; E S Medlock; F J Bollum; L Schultz
Defective lymphopoiesis in bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. I. Analysis of development of prothymocytes, early B lineage cells, and terminal deoxynucleotidyl transferase-positive cells.
The Journal of experimental medicine 1986;164(4):1129-44.
1986: Irving Goldschneider; K L Komschlies; Dale L Greiner
Studies of thymocytopoiesis in rats and mice. I. Kinetics of appearance of thymocytes using a direct intrathymic adoptive transfer assay for thymocyte precursors.
The Journal of experimental medicine 1986;163(1):1-17.
1985: R W Barton; Dale L Greiner; E S Medlock; Irving Goldschneider
Phenotypic heterogeneity of Gross virus-induced thymic lymphomas in the rat: cellular origins and migratory properties.
Cellular immunology 1985;94(1):113-21.
1984: Dale L Greiner; Irving Goldschneider; D M Lubaroff
Identification of thymocyte progenitors in hemopoietic tissues of the rat. I. A quantitative assay system for thymocyte regeneration.
Thymus 1984;6(3):181-99.
1982: Dale L Greiner; Irving Goldschneider; R W Barton
Identification of thymocyte progenitors in hemopoietic tissues of the rat. II. Enrichment of functional prothymocytes on the fluorescence-activated cell sorter.
The Journal of experimental medicine 1982;156(5):1448-60.
1982: Dale L Greiner; R W Barton; Irving Goldschneider; D M Lubaroff
Genetic linkage and cell distribution analysis of T cell alloantigens in the rat.
Journal of immunogenetics 1982;9(1):43-50.
1981: Dale L Greiner; Irving Goldschneider; R W Barton; D M Lubaroff
A quantitative assay system for thymocyte regeneration in the rat.
Transplantation proceedings 1981;13(2):1457-9.