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Philippe Grellier

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TOP 3
Sébastien Lethu; Elisabeth Mouray; Damien Bosc; Philippe Grellier; Joëlle Dubois
New protein farnesyltransferase inhibitors in the 3-arylthiophene 2-carboxylic acid series: diversification of the aryl moiety by solid-phase synthesis.
Katalina Muñoz-Durango; Jérôme Quintin; Kevin Spelman; Sandra Torijano-Gutiérrez; Philippe Grellier; Abha Harfouche; Jean-Christophe Jullian; Alexandre Maciuk; Elisabeth Mouray; Bruno Figadère
Detection, characterization, and screening of heme-binding molecules by mass spectrometry for malaria drug discovery.
Lorena Carneiro Albernaz; Laila Salmen Espindola; Bernard Bodo; José Elias de Paula; Alexandre Deville; Lionel Dubost; Philippe Grellier; Lengo Mambu
Spiranthenones A and B, tetraprenylated phloroglucinol derivatives from the leaves of Spiranthera odoratissima.

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All Publications

2013: Sébastien Lethu; Elisabeth Mouray; Damien Bosc; Philippe Grellier; Joëlle Dubois
New protein farnesyltransferase inhibitors in the 3-arylthiophene 2-carboxylic acid series: diversification of the aryl moiety by solid-phase synthesis.
Journal of enzyme inhibition and medicinal chemistry 2013;28(1):163-71.
2012: Katalina Muñoz-Durango; Jérôme Quintin; Kevin Spelman; Sandra Torijano-Gutiérrez; Philippe Grellier; Abha Harfouche; Jean-Christophe Jullian; Alexandre Maciuk; Elisabeth Mouray; Bruno Figadère
Detection, characterization, and screening of heme-binding molecules by mass spectrometry for malaria drug discovery.
Analytical chemistry 2012;84(7):3324-9.
2012: Lorena Carneiro Albernaz; Laila Salmen Espindola; Bernard Bodo; José Elias de Paula; Alexandre Deville; Lionel Dubost; Philippe Grellier; Lengo Mambu
Spiranthenones A and B, tetraprenylated phloroglucinol derivatives from the leaves of Spiranthera odoratissima.
Planta medica 2012;78(5):459-64.
2011: Kevin Spelman; Delphine Depoix; Megan McCray; Elisabeth Mouray; Philippe Grellier
The traditional medicine Spilanthes acmella, and the alkylamides spilanthol and undeca-2E-ene-8,10-diynoic acid isobutylamide, demonstrate in vitro and in vivo antimalarial activity.
Phytotherapy research : PTR 2011;25(7):1098-101.
2011: Jean Guillon; Elisabeth Mouray; Stéphane Moreau; Catherine Mullié; Isabelle Forfar; Vanessa Desplat; Solene Belisle-Fabre; Noël Pinaud; François Ravanello; Augustin Le-Naour; Jean-Michel Léger; Grace Gosmann; Christian Jarry; Gérard Déléris; Pascal Sonnet; Philippe Grellier
New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: synthesis, and in vitro antimalarial activity--Part II.
European journal of medicinal chemistry 2011;46(6):2310-26.
2010: Lorena Carneiro Albernaz; José Elias de Paula; Gustavo Adolfo Sierra Romero; Maria do Rosário Rodrigues Silva; Philippe Grellier; Lengo Mambu; Laila Salmen Espindola
Investigation of plant extracts in traditional medicine of the Brazilian Cerrado against protozoans and yeasts.
Journal of ethnopharmacology 2010;131(1):116-21.
2010: Izabela M D Bastos; Flávia Nader Motta; Sébastien Charneau; Jaime M Santana; lionel dubost; Koen Augustyns; Philippe Grellier
Prolyl oligopeptidase of Trypanosoma brucei hydrolyzes native collagen, peptide hormones and is active in the plasma of infected mice.
Microbes and infection / Institut Pasteur 2010;12(6):457-66.
2010: Philippe Grellier; Audrone Maroziene; Henrikas Nivinskas; Jonas Sarlauskas; Alessandro Aliverti; Narimantas Cenas
Antiplasmodial activity of quinones: roles of aziridinyl substituents and the inhibition of Plasmodium falciparum glutathione reductase.
Archives of biochemistry and biophysics 2010;494(1):32-9.
2010: Stéphanie Duez; Laëtitia Coudray; Elisabeth Mouray; Philippe Grellier; Joëlle Dubois
Towards the synthesis of bisubstrate inhibitors of protein farnesyltransferase: Synthesis and biological evaluation of new farnesylpyrophosphate analogues.
Bioorganic & medicinal chemistry 2010;18(2):543-56.
2009: Raphaël Demonchy; Thierry Blisnick; Caroline Deprez; Géraldine Toutirais; Céline Loussert; William Marande; Philippe Grellier; Philippe Bastin; Linda Kohl
Kinesin 9 family members perform separate functions in the trypanosome flagellum.
The Journal of cell biology 2009;187(5):615-22.
2009: Hichem Henchiri; Bernard Bodo; Alexandre Deville; Lionel Dubost; Lazhar Zourgui; Aly Raies; Philippe Grellier; Lengo Mambu
Sesquiterpenoids from Teucrium ramosissimum.
Phytochemistry 2009;70(11-12):1435-41.
2009: Emilia Păunescu; Sophie Susplugas; Emmanuelle Boll; Richard Varga; Elisabeth Mouray; Ion Grosu; Philippe Grellier; Patricia Melnyk
Replacement of the 4'-hydroxy group of amodiaquine and amopyroquine by aromatic and aliphatic substituents: synthesis and antimalarial activity.
ChemMedChem 2009;4(4):549-61.
2009: Isabelle Florent; Betina M Porcel; Elodie Guillaume; Corinne Da Silva; François Artiguenave; Eric Maréchal; Laurent Bréhélin; Olivier Gascuel; Sébastien Charneau; Patrick Wincker; Philippe Grellier
A Plasmodium falciparum FcB1-schizont-EST collection providing clues to schizont specific gene structure and polymorphism.
BMC genomics 2009;10():235.
2009: Guillaume Marti; Véronique Eparvier; Christian Moretti; Sophie Susplugas; Soizic Prado; Philippe Grellier; Pascal Retailleau; Françoise Guéritte; Marc Litaudon
Antiplasmodial benzophenones from the trunk latex of Moronobea coccinea (Clusiaceae).
Phytochemistry 2009;70(1):75-85.
2008: Ngoc Tuan Nguyen; Van Cuong Pham; Marc Litaudon; Françoise Guéritte; Philippe Grellier; Van Tuyen Nguyen; Van Hung Nguyen
Antiplasmodial alkaloids from Desmos rostrata.
Journal of natural products 2008;71(12):2057-9.
2008: Anne DE CIAN; Philippe Grellier; Elisabeth Mouray; Delphine Depoix; Hélène Bertrand; David Monchaud; Marie-Paule Teulade-Fichou; Jean-Louis Mergny; Patrizia Alberti
Plasmodium telomeric sequences: structure, stability and quadruplex targeting by small compounds.
Chembiochem : a European journal of chemical biology 2008;9(16):2730-9.
2008: Jean Guillon; Stéphane Moreau; Elisabeth Mouray; Véronique Sinou; Isabelle Forfar; Solene Belisle Fabre; Vanessa Desplat; Pascal Millet; Daniel Parzy; Christian Jarry; Philippe Grellier
New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: synthesis, and in vitro antimalarial activity.
Bioorganic & medicinal chemistry 2008;16(20):9133-44.
2008: Van Cuong Pham; Akino Jossang; Philippe Grellier; Thierry Sévenet; Van Hung Nguyen; Bernard Bodo
Structure and total synthesis of (-)-myrionidine and (-)-schoberine, antimalarial alkaloids from Myrioneuron nutans.
The Journal of organic chemistry 2008;73(19):7565-73.
2008: Sandrine Delarue-Cochin; Philippe Grellier; Louis Maes; Elisabeth Mouray; Christian Sergheraert; Patricia Melnyk
Synthesis and antimalarial activity of carbamate and amide derivatives of 4-anilinoquinoline.
European journal of medicinal chemistry 2008;43(10):2045-55.
2008: Philippe Grellier; Jorge Benach; Mehdi Labaied; Sébastien Charneau; Horacio Gil; Gloria Monsalve; Ryan Alfonso; Lynette Sawyer; Lily Lin; Matthias Steiert; Kent Dupuis
Photochemical inactivation with amotosalen and long-wavelength ultraviolet light of Plasmodium and Babesia in platelet and plasma components.
Transfusion 2008;48(8):1676-84.
2008: Philippe Grellier; Ausra Nemeikaite-Ceniene; Jonas Sarlauskas; Narimantas Cenas
Role of single-electron oxidation potential and lipophilicity in the antiplasmodial in vitro activity of polyphenols: comparison to mammalian cells.
Zeitschrift für Naturforschung. C, Journal of biosciences 2008;63(5-6):445-50.
2008: Voahangy Ramanandraibe; Philippe Grellier; Marie-Thérèse Martin; Alexandre Deville; Roger Joyeau; David Ramanitrahasimbola; Elisabeth Mouray; Philippe Rasoanaivo; Lengo Mambu
Antiplasmodial phenolic compounds from Piptadenia pervillei.
Planta medica 2008;74(4):417-21.
2008: Sandrine Delarue-Cochin; Emilia Paunescu; Louis Maes; Elisabeth Mouray; Christian Sergheraert; Philippe Grellier; Patricia Melnyk
Synthesis and antimalarial activity of new analogues of amodiaquine.
European journal of medicinal chemistry 2008;43(2):252-60.
2008: Simone C B Gnoatto; Sophie Susplugas; Luciana Dalla Vechia; Thais B Ferreira; Alexandra Dassonville-Klimpt; Karine R Zimmer; Catherine Demailly; Sophie Da Nascimento; Jean Guillon; Philippe Grellier; Hugo Verli; Grace Gosmann; Pascal Sonnet
Pharmacomodulation on the 3-acetylursolic acid skeleton: Design, synthesis, and biological evaluation of novel N-{3-[4-(3-aminopropyl)piperazinyl]propyl}-3-O-acetylursolamide derivatives as antimalarial agents.
Bioorganic & medicinal chemistry 2008;16(2):771-82.
2008: Vincent Robert; Catherine Bourgouin; Delphine Depoix; Catherine Thouvenot; Marie-Noëlle Lombard; Philippe Grellier
Malaria and obesity: obese mice are resistant to cerebral malaria.
Malaria journal 2008;7():81.
2007: Sébastien Charneau; Izabela M D Bastos; Elisabeth Mouray; Bergmann Morais Ribeiro; Jaime M Santana; Philippe Grellier; Isabelle Florent
Characterization of PfDYN2, a dynamin-like protein of Plasmodium falciparum expressed in schizonts.
Microbes and infection / Institut Pasteur 2007;9(7):797-805.
2007: Elisabeth Mouray; Mireille Moutiez; Sophie Girault; Christian Sergheraert; Isabelle Florent; Philippe Grellier
Biochemical properties and cellular localization of Plasmodium falciparum protein disulfide isomerase.
Biochimie 2007;89(3):337-46.
2007: Mariana Laundry de Mesquita; Philippe Grellier; Lengo Mambu; José Elias de Paula; Laila Salmen Espindola
In vitro antiplasmodial activity of Brazilian Cerrado plants used as traditional remedies.
Journal of ethnopharmacology 2007;110(1):165-70.
2007: Gwenola Auffret; Mehdi Labaied; François Frappier; Philippe Rasoanaivo; Philippe Grellier; Guy Lewin
Synthesis and antimalarial evaluation of a series of piperazinyl flavones.
Bioorganic & medicinal chemistry letters 2007;17(4):959-63.
2006: Katja Zmitek; Stojan Stavber; Marko Zupan; Danièle Bonnet-Delpon; Sebastien Charneau; Philippe Grellier; Jernej Iskra
Synthesis and antimalarial activities of novel 3,3,6,6-tetraalkyl-1,2,4,5-tetraoxanes.
Bioorganic & medicinal chemistry 2006;14(23):7790-5.
2006: Lengo Mambu; Philippe Grellier; Loic Florent; Roger Joyeau; David Ramanitrahasimbola; Philippe Rasoanaivo; François Frappier
Clerodane and labdane diterpenoids from Nuxia sphaerocephala.
Phytochemistry 2006;67(5):444-51.
2006: Patricia Melnyk; Virginie Leroux; Christian Sergheraert; Philippe Grellier
Design, synthesis and in vitro antimalarial activity of an acylhydrazone library.
Bioorganic & medicinal chemistry letters 2006;16(1):31-5.
2005: Mariana Laundry de Mesquita; Julie Desrivot; Christian Bories; Alain Fournet; José Elias de Paula; Philippe Grellier; Laila Salmen Espindola
Antileishmanial and trypanocidal activity of Brazilian Cerrado plants.
Memórias do Instituto Oswaldo Cruz 2005;100(7):783-7.
2005: Adina Ryckebusch; Pauline Gilleron; Régis Millet; Raymond Houssin; Amélie Lemoine; Nicole Pommery; Philippe Grellier; Christian Sergheraert; Jean-Pierre Hénichart
Novel N-(4-Piperidinyl)benzamide antimalarials with mammalian protein farnesyltransferase inhibitory activity.
Chemical & pharmaceutical bulletin 2005;53(10):1324-6.
2005: Mariana Laundry de Mesquita; Philippe Grellier; Alain Blond; Jean-Paul Brouard; José Elias de Paula; Laila Salmen Espindola; Lengo Mambu
New ether diglycosides from Matayba guianensis with antiplasmodial activity.
Bioorganic & medicinal chemistry 2005;13(14):4499-506.
2005: Guédé Noël Zirihi; Philippe Grellier; Frédérick Guédé-Guina; Bernard Bodo; Lengo Mambu
Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf.
Bioorganic & medicinal chemistry letters 2005;15(10):2637-40.
2005: Izabela M D Bastos; Philippe Grellier; Natalia Martins; Gloria Cadavid-Restrepo; Marian R de Souza-Ault; Koen Augustyns; Antonio R L Teixeira; Joseph Schrével; Bernard Maigret; José F da Silveira; Jaime M Santana
Molecular, functional and structural properties of the prolyl oligopeptidase of Trypanosoma cruzi (POP Tc80), which is required for parasite entry into mammalian cells.
The Biochemical journal 2005;388(Pt 1):29-38.
2005: Voahangy Ramanandraibe; Marie-Thérèse Martin; Dina L Rakotondramanana; Lengo Mambu; David Ramanitrahasimbola; Mehdi Labaïed; Philippe Grellier; Philippe Rasoanaivo; François Frappier
Pseudoguanolide sesquiterpene lactones from Vernoniopsis caudata and their in vitro antiplasmodial activities.
Journal of natural products 2005;68(5):800-3.
2005: Guédé Noël Zirihi; Lengo Mambu; Frédéric Guédé-Guina; Bernard Bodo; Philippe Grellier
In vitro antiplasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria.
Journal of ethnopharmacology 2005;98(3):281-5.
2005: Fabienne Grellepois; Philippe Grellier; Danièle Bonnet-Delpon; Jean-Pierre Bégué
Design, synthesis and antimalarial activity of trifluoromethylartemisinin-mefloquine dual molecules.
Chembiochem : a European journal of chemical biology 2005;6(4):648-52.
2005: Luciana C Fernandes; Izabela M D Bastos; Liana Lauria-Pires; Ana C O Rosa; Antonio R L Teixeira; Philippe Grellier; Joseph Schrével; Jaime M Santana
Specific human antibodies do not inhibit Trypanosoma cruzi oligopeptidase B and cathepsin B, and immunoglobulin G enhances the activity of trypomastigote-secreted oligopeptidase B.
Microbes and infection / Institut Pasteur 2005;7(3):375-84.
2005: Adina Ryckebusch; Marie-Ange Debreu-Fontaine; Elisabeth Mouray; Philippe Grellier; Christian Sergheraert; Patricia Melnyk
Synthesis and antimalarial evaluation of new N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives.
Bioorganic & medicinal chemistry letters 2005;15(2):297-302.
2004: Mehdi Labaied; Arie Dagan; Marc Dellinger; Marc Gèze; Stéphane Egée; Serge L Y Thomas; Chunbo Wang; Shimon Gatt; Philippe Grellier
Anti-Plasmodium activity of ceramide analogs.
Malaria journal 2004;3():49.
2004: Anne-Emmanuelle Hay; Jean-Jacques Hélesbeux; Olivier Duval; Mehdi Labaïed; Philippe Grellier; Pascal Richomme
Antimalarial xanthones from Calophyllum caledonicum and Garcinia vieillardii.
Life sciences 2004;75(25):3077-85.
2004: Adina Ryckebusch; J-S Fruchart; L Cattiaux; P Rousselot-Paillet; V Leroux; Oleg Melnyk; Philippe Grellier; Elisabeth Mouray; Christian Sergheraert; Patricia Melnyk
Design, synthesis and antimalarial activity of a glyoxylylhydrazone library.
Bioorganic & medicinal chemistry letters 2004;14(17):4439-43.
2004: Philippe Rasoanaivo; David Ramanitrahasimbola; Herintsoa Rafatro; Dina L Rakotondramanana; Baholy Robijaona; Armand Rakotozafy; Suzanne Ratsimamanga-Urverg; Mehdi Labaïed; Philippe Grellier; Lucile Allorge; Lengo Mambu; François Frappier
Screening extracts of Madagascan plants in search of antiplasmodial compounds.
Phytotherapy research : PTR 2004;18(9):742-7.
2004: Guillaume Magueur; Benoit Crousse; Sébastien Charneau; Philippe Grellier; Jean-Pierre Bégué; Danièle Bonnet-Delpon
Fluoroartemisinin: trifluoromethyl analogues of artemether and artesunate.
Journal of medicinal chemistry 2004;47(10):2694-9.
2004: Isabelle Florent; Sébastien Charneau; Philippe Grellier
Plasmodium falciparum genes differentially expressed during merozoite morphogenesis.
Molecular and biochemical parasitology 2004;135(1):143-8.
2004: Jean Guillon; Philippe Grellier; Mehdi Labaied; Pascal Sonnet; Jean-Michel Léger; Rébecca Déprez-Poulain; Isabelle Forfar-Bares; Patrick Dallemagne; Nicolas Lemaître; Fabienne Péhourcq; Jacques Rochette; Christian Sergheraert; Christian Jarry
Synthesis, antimalarial activity, and molecular modeling of new pyrrolo[1,2-a]quinoxalines, bispyrrolo[1,2-a]quinoxalines, bispyrido[3,2-e]pyrrolo[1,2-a]pyrazines, and bispyrrolo[1,2-a]thieno[3,2-e]pyrazines.
Journal of medicinal chemistry 2004;47(8):1997-2009.
2004: Fabienne Grellepois; Fatima Chorki; Michèle Ourévitch; Sébastien Charneau; Philippe Grellier; Kylie A McIntosh; William N Charman; Bruno Pradines; Benoit Crousse; Danièle Bonnet-Delpon; Jean-Pierre Bégué
Orally active antimalarials: hydrolytically stable derivatives of 10-trifluoromethyl anhydrodihydroartemisinin.
Journal of medicinal chemistry 2004;47(6):1423-33.
2004: T Okpekon; S Yolou; Christophe Gleye; France Roblot; P Loiseau; Christian Bories; Philippe Grellier; François Frappier; Alain Laurens; Reynald Hocquemiller
Antiparasitic activities of medicinal plants used in Ivory Coast.
Journal of ethnopharmacology 2004;90(1):91-7.
2003: Adina Ryckebusch; Rébecca Deprez-Poulain; Marie-Ange Debreu-Fontaine; Richard Vandaele; Elisabeth Mouray; Philippe Grellier; Christian Sergheraert
Synthesis and antimalarial evaluation of new 1,4-bis(3-aminopropyl)piperazine derivatives.
Bioorganic & medicinal chemistry letters 2003;13(21):3783-7.
2003: Naïma Beldjoudi; Lengo Mambu; Mehdi Labaïed; Philippe Grellier; David Ramanitrahasimbola; Philippe Rasoanaivo; Marie-Thérèse Martin; François Frappier
Flavonoids from Dalbergia louvelii and their antiplasmodial activity.
Journal of natural products 2003;66(11):1447-50.
2003: Marion Flipo; Isabelle Florent; Philippe Grellier; Christian Sergheraert; Rébecca Deprez-Poulain
Design, synthesis and antimalarial activity of novel, quinoline-based, zinc metallo-aminopeptidase inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(16):2659-62.
2003: Adina Ryckebusch; Rébecca Deprez-Poulain; Louis Maes; Marie-Ange Debreu-Fontaine; Elisabeth Mouray; Philippe Grellier; Christian Sergheraert
Synthesis and in vitro and in vivo antimalarial activity of N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives.
Journal of medicinal chemistry 2003;46(4):542-57.
2003: christophe biot; Jean Dessolin; Philippe Grellier; Elisabeth Davioud
Double-drug development against antioxidant enzymes from Plasmodium falciparum.
Redox report : communications in free radical research 2003;8(5):280-3.
2002: Jean-Jacques HELESBEUX; Damien Peyronnet; Mehdi Labaïed; Philippe Grellier; François Frappier; Denis Seraphin; Pascal Richomme; Olivier Duval
Synthesis and antimalarial activity of some new 1,2-dioxolane derivatives.
Journal of enzyme inhibition and medicinal chemistry 2002;17(6):431-7.
2002: Adina Ryckebusch; R Déprez-Poulain; Marie-Ange Debreu-Fontaine; R Vandaele; Elisabeth Mouray; Philippe Grellier; Christian Sergheraert
Parallel synthesis and anti-malarial activity of a sulfonamide library.
Bioorganic & medicinal chemistry letters 2002;12(18):2595-8.
2002: Sandrine Vendeville; Filip Goossens; Marie-Ange Debreu-Fontaine; Valérie Landry; Elisabeth Davioud; Philippe Grellier; Simon Scharpe; Christian Sergheraert
Comparison of the inhibition of human and Trypanosoma cruzi prolyl endopeptidases.
Bioorganic & medicinal chemistry 2002;10(6):1719-29.
2002: Lengo Mambu; Voahangy Ramanandraibe; Marie-Thérèse Martin; Alain Blond; Philippe Grellier; François Frappier
Constituents of Burasaïa madagascarensis: a new clerodane-type diterpene.
Planta medica 2002;68(4):377-9.
2002: Blandine Akendengue; Edouard Ngou-Milama; France Roblot; Alain Laurens; Reynald Hocquemiller; Philippe Grellier; François Frappier
Antiplasmodial activity of Uvaria klaineana.
Planta medica 2002;68(2):167-9.
2001: Philippe Grellier; Sandrine Vendeville; Roger Joyeau; Izabela M D Bastos; Hervé Drobecq; François Frappier; Antonio R L Teixeira; Joseph Schrével; Elisabeth Davioud; Christian Sergheraert; Jaime M Santana
Trypanosoma cruzi prolyl oligopeptidase Tc80 is involved in nonphagocytic mammalian cell invasion by trypomastigotes.
The Journal of biological chemistry 2001;276(50):47078-86.
2001: Elisabeth Davioud; S Delarue; christophe biot; B Schwöbel; C C Boehme; A Müssigbrodt; Louis Maes; Christian Sergheraert; Philippe Grellier; R Heiner Schirmer; Katja Becker
A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline.
Journal of medicinal chemistry 2001;44(24):4268-76.
2001: Philippe Grellier; Jonas Sarlauskas; Zilvinas Anusevicius; Audrone Maroziene; C Houee-Levin; J Schrevel; Narimantas Cenas
Antiplasmodial activity of nitroaromatic and quinoidal compounds: redox potential vs. inhibition of erythrocyte glutathione reductase.
Archives of biochemistry and biophysics 2001;393(2):199-206.
2001: S Delarue; Sophie Girault; Louis Maes; Marie-Ange Debreu-Fontaine; M Labaeïd; Philippe Grellier; Christian Sergheraert
Synthesis and in vitro and in vivo antimalarial activity of new 4-anilinoquinolines.
Journal of medicinal chemistry 2001;44(17):2827-33.
2001: S Delarue; Sophie Girault; F Dali Ali; Louis Maes; Philippe Grellier; Christian Sergheraert
"One-pot" synthesis and antimalarial activity of formamidine derivatives of 4-anilinoquinoline.
Chemical & pharmaceutical bulletin 2001;49(8):933-7.
2001: Sophie Girault; S Delarue; Philippe Grellier; A Berecibar; Louis Maes; Ludo Quirijnen; P Lemiere; Marie-Ange Debreu-Fontaine; Christian Sergheraert
Antimalarial in-vivo activity of bis(9-amino-6-chloro-2-methoxyacridines).
The Journal of pharmacy and pharmacology 2001;53(7):935-8.
2001: Sophie Girault; Philippe Grellier; A Berecibar; Louis Maes; P Lemière; Elisabeth Mouray; Elisabeth Davioud; Christian Sergheraert
Antiplasmodial activity and cytotoxicity of bis-, tris-, and tetraquinolines with linear or cyclic amino linkers.
Journal of medicinal chemistry 2001;44(11):1658-65.
2001: E Arzel; P Rocca; Philippe Grellier; M Labaeïd; François Frappier; Françoise Guéritte; C Gaspard; Francis Marsais; A Godard; Guy Quéguiner
New synthesis of benzo-delta-carbolines, cryptolepines, and their salts: in vitro cytotoxic, antiplasmodial, and antitrypanosomal activities of delta-carbolines, benzo-delta-carbolines, and cryptolepines.
Journal of medicinal chemistry 2001;44(6):949-60.
2000: Isabelle Florent; Elisabeth Mouray; F Dali Ali; Hervé Drobecq; Sophie Girault; Joseph Schrével; Christian Sergheraert; Philippe Grellier; I Florenta
Cloning of Plasmodium falciparum protein disulfide isomerase homologue by affinity purification using the antiplasmodial inhibitor 1,4-bis[3-[N-(cyclohexyl methyl)amino]propyl]piperazine..
FEBS letters 2000;484(3):246-52.
2000: Sophie Girault; Philippe Grellier; A Berecibar; Louis Maes; Elisabeth Mouray; P Lemière; MA Debreu; Elisabeth Davioud; Christian Sergheraert
Antimalarial, antitrypanosomal, and antileishmanial activities and cytotoxicity of bis(9-amino-6-chloro-2-methoxyacridines): influence of the linker.
Journal of medicinal chemistry 2000;43(14):2646-54.
2000: Roger Joyeau; C Maoulida; C Guillet; François Frappier; Antonio R L Teixeira; Joseph Schrével; Jaime M Santana; Philippe Grellier
Synthesis and activity of pyrrolidinyl- and thiazolidinyl-dipeptide derivatives as inhibitors of the Tc80 prolyl oligopeptidase from Trypanosoma cruzi.
European journal of medicinal chemistry 2000;35(2):257-66.
1999: S Le Bonniec; Christiane Deregnaucourt; V Redeker; R Banerjee; Philippe Grellier; D E Goldberg; Joseph Schrével
Plasmepsin II, an acidic hemoglobinase from the Plasmodium falciparum food vacuole, is active at neutral pH on the host erythrocyte membrane skeleton.
The Journal of biological chemistry 1999;274(20):14218-23.
1999: Sandrine Vendeville; L Bourel; Elisabeth Davioud; Philippe Grellier; B Deprez; Christian Sergheraert
Automated parallel synthesis of a tetrahydroisoquinolin-based library: potential prolyl endopeptidase inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(3):437-42.
1999: Sandrine Vendeville; E Buisine; X Williard; J Schrevel; Philippe Grellier; Jaime M Santana; Christian Sergheraert
Identification of inhibitors of an 80 kDa protease from Trypanosoma cruzi through the screening of a combinatorial peptide library.
Chemical & pharmaceutical bulletin 1999;47(2):194-8.
1999: Philippe Grellier; J Blum; Jaime M Santana; E Bylèn; Elisabeth Mouray; Véronique Sinou; Antonio R L Teixeira; Joseph Schrével
Involvement of calyculin A-sensitive phosphatase(s) in the differentiation of Trypanosoma cruzi trypomastigotes to amastigotes.
Molecular and biochemical parasitology 1999;98(2):239-52.
1999: Philippe Grellier; Véronique Sinou; N Garreau-de Loubresse; E Bylèn; Y Boulard; Joseph Schrével
Selective and reversible effects of vinca alkaloids on Trypanosoma cruzi epimastigote forms: blockage of cytokinesis without inhibition of the organelle duplication.
Cell motility and the cytoskeleton 1999;42(1):36-47.
1998: René Santus; Philippe Grellier; Joseph Schrével; Jean-Claude Mazière; J F Stoltz
Photodecontamination of blood components: advantages and drawbacks.
Clinical hemorheology and microcirculation 1998;18(4):299-308.
1998: Véronique Sinou; Y Boulard; Philippe Grellier; J Schrevel
Host cell and malarial targets for docetaxel (Taxotere) during the erythrocytic development of Plasmodium falciparum.
The Journal of eukaryotic microbiology 1998;45(2):171-83.
1997: Jaime M Santana; Philippe Grellier; Joseph Schrével; Antonio R L Teixeira
A Trypanosoma cruzi-secreted 80 kDa proteinase with specificity for human collagen types I and IV.
The Biochemical journal 1997;325 ( Pt 1)():129-37.
1997: Philippe Grellier; René Santus; Elisabeth Mouray; V Agmon; Jean-Claude Mazière; D Rigomier; Arie Dagan; Shimon Gatt; Joseph Schrével
Photosensitized inactivation of Plasmodium falciparum- and Babesia divergens-infected erythrocytes in whole blood by lipophilic pheophorbide derivatives.
Vox sanguinis 1997;72(4):211-20.
1996: S L Le Bonniec; C Fournier; C Deregnaucourt; Philippe Grellier; D Dhermy; M C Lecomte; J Schrevel
Human erythroid spectrin alpha subunit and its SH3 domain are sensitive to acidic Plasmodium falciparum proteolytic activity.
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1996;319(11):1011-7.
1996: F Frappier; A Jossang; J Soudon; F Calvo; Philippe Rasoanaivo; Suzanne Ratsimamanga-Urverg; J Saez; J Schrevel; Philippe Grellier
Bisbenzylisoquinolines as modulators of chloroquine resistance in Plasmodium falciparum and multidrug resistance in tumor cells.
Antimicrobial agents and chemotherapy 1996;40(6):1476-81.
1996: Véronique Sinou; Philippe Grellier; J Schrevel
In vitro and in vivo inhibition of erythrocytic development of malarial parasites by docetaxel.
Antimicrobial agents and chemotherapy 1996;40(2):358-61.
1996: Joseph Schrével; V Millerioux; Véronique Sinou; F Frappier; R Santus; Philippe Grellier
New trends in chemotherapy on human and animal blood parasites.
Parasitology research 1996;82(3):283-4.
1994: Bernard Carcy; Serge Bonnefoy; Micheline Guillotte; Cecile Le Scanf; Philippe Grellier; J Schrevel; Thierry Fandeur; Odile Mercereau-Puijalon
A large multigene family expressed during the erythrocytic schizogony of Plasmodium falciparum.
Molecular and biochemical parasitology 1994;68(2):221-33.
1994: Joseph Schrével; Véronique Sinou; Philippe Grellier; F Frappier; D Guénard; P Potier
Interactions between docetaxel (Taxotere) and Plasmodium falciparum-infected erythrocytes.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(18):8472-6.
1994: Philippe Grellier; A Valentin; V Millerioux; J Schrevel; D Rigomier
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors lovastatin and simvastatin inhibit in vitro development of Plasmodium falciparum and Babesia divergens in human erythrocytes.
Antimicrobial agents and chemotherapy 1994;38(5):1144-8.
1994: Philippe Grellier; Eric Précigout; A Valentin; Bernard Carcy; Joseph Schrével
Characterization of a new 60 kDa apical protein of Plasmodium falciparum merozoite expressed in late schizogony.
Biology of the cell / under the auspices of the European Cell Biology Organization 1994;82(2-3):129-38.
1994: Isabelle Florent; S Le Bonniec; Bernard Carcy; Philippe Grellier; Odile Mercereau-Puijalon; Serge Bonnefoy; D Dhermy; Michel Monsigny; R Mayer; Joseph Schrével
Plasmodium falciparum proteinases: cloning of the putative gene coding for the merozoite proteinase for erythrocyte invasion (MPEI) and determination of hydrolysis sites of spectrin by Pf37 proteinase.
Memórias do Instituto Oswaldo Cruz 1994;89 Suppl 2():47-9.
1993: Joseph Schrével; C Barrault; A Deguercy; Philippe Grellier; P Lawton; H G Heidrich; M Caballero; Michel Monsigny; R Mayer
Plasmodium falciparum proteinases and red blood cell invasion.
Parassitologia 1993;35 Suppl():103-5.
1992: Jaime M Santana; Philippe Grellier; M H Rodier; J Schrevel; A Teixeira
Purification and characterization of a new 120 kDa alkaline proteinase of Trypanosoma cruzi.
Biochemical and biophysical research communications 1992;187(3):1466-73.
1992: J Schrevel; Philippe Grellier; D Rigomier
New approaches in in vitro cultures of Plasmodium falciparum and Babesia divergens by using serum-free medium based on human high density lipoproteins.
Memórias do Instituto Oswaldo Cruz 1992;87 Suppl 3():71-5.
1991: J M Gallo; D Escalier; Philippe Grellier; Eric Précigout; M Albert; G David; Joseph Schrével
Characterization of a monoclonal antibody to human proacrosin and its use in acrosomal status evaluation.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1991;39(3):273-82.
1991: PH Jakobsen; Philippe Grellier; Thor G Theander; N Behrendt; M Torii; M Aikawa; J Schrevel; S Jepsen
Identification and localization of a soluble antigen, Ag2, of 136 kDa from Plasmodium falciparum in vitro cultures.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1991;99(2):155-62.
1991: PH Jakobsen; Lars Hviid; Thor G Theander; Eleanor M Riley; Philippe Grellier; L S Bruun; K Dalsgaard; J Schrevel; S Jepsen
Isolation and characterization of a soluble antigen complex of Plasmodium falciparum with pyrogenic properties.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1991;99(1):21-9.
1991: Philippe Grellier; D Rigomier; V Clavey; J C Fruchart; J Schrevel
Lipid traffic between high density lipoproteins and Plasmodium falciparum-infected red blood cells.
The Journal of cell biology 1991;112(2):267-77.
1991: P Lawton; C Barrault; Philippe Grellier; Joseph Schrével; H G Heidrich
The native form of the Plasmodium falciparum Pf68 neutral proteinase is a 105,000-Da polypeptide.
Parasitology research 1991;77(8):720-2.
1990: PH Jakobsen; S Jepsen; Eleanor M Riley; Thor G Theander; Philippe Grellier; A Lihme; Lars Hviid; M Dziegiel; J Schrevel
Biochemical characterization, localization and immunostimulating properties of a soluble glycoprotein, Ag1, isolated from in vitro cultures of Plasmodium falciparum.
Parasitology research 1990;76(8):657-61.
1990: Philippe Grellier; D Rigomier; Joseph Schrével
[In vitro induction of Plasmodium falciparum schizogony by human high density lipoproteins (HDL)].
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1990;311(10):361-7.
1989: Philippe Grellier; I Picard; F Bernard; R Mayer; H G Heidrich; Michel Monsigny; Joseph Schrével
Purification and identification of a neutral endopeptidase in Plasmodium falciparum schizonts and merozoites.
Parasitology research 1989;75(6):455-60.
1988: J Schrevel; Philippe Grellier; R Mayer; Michel Monsigny
Neutral proteases involved in the reinvasion of erythrocytes by Plasmodium merozoites.
Biology of the cell / under the auspices of the European Cell Biology Organization 1988;64(2):233-44.