FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Jean Grem

Research Profile

Chemicals & Drugs

Procedures

Concepts & Ideas

Disorders

Anatomy

Tumor Cells, Cultured

Co-author Network

Publications

TOP 3
Al B Benson; Emily Chan; Yi-Jen Chen; Michael A Choti; Harry S Cooper; Paul F Engstrom; Peter C Enzinger; Marwan G Fakih; Deborah A Freedman-Cass; Charles S Fuchs; Tanios Bekaii-Saab; Jean L Grem; Steven Hunt; Lucille A Leong; Edward Lin; Michael G Martin; Kilian Salerno May; Mary F Mulcahy; Kate Murphy; Eric Rohren; David P Ryan; Leonard Saltz; Sunil Sharma; David Shibata; John M Skibber; William Small; Constantinos T Sofocleous; Alan P Venook; Christopher G Willett; Kristina M Gregory
Rectal cancer.
Al B Benson; Emily Chan; Yi-Jen Chen; Michael A Choti; Harry S Cooper; Raza A Dilawari; Paul F Engstrom; Peter C Enzinger; Marwan G Fakih; James W Fleshman; Deborah A Freedman-Cass; Charles S Fuchs; Jean L Grem; Lucille A Leong; Edward Lin; Kilian Salerno May; Mary F Mulcahy; Kate Murphy; Eric Rohren; David P Ryan; Leonard Saltz; Sunil Sharma; David Shibata; John M Skibber; William Small; Constantinos T Sofocleous; Alan P Venook; Christopher Willett; J Pablo Arnoletti; Tanios Bekaii-Saab
Anal Carcinoma, Version 2.2012: featured updates to the NCCN guidelines.
Al B Benson; Emily Chan; Yi-Jen Chen; Michael A Choti; Harry S Cooper; Raza A Dilawari; Paul F Engstrom; Peter C Enzinger; James W Fleshman; Charles S Fuchs; Jean L Grem; James A Knol; Lucille A Leong; Edward Lin; Kilian Salerno May; Mary F Mulcahy; Kate Murphy; Eric Rohren; David P Ryan; Leonard Saltz; Sunil Sharma; David Shibata; John M Skibber; William Small; Constantinos T Sofocleous; Alan P Venook; Christopher Willett; J Pablo Arnoletti; Tanios Bekaii-Saab
Colon cancer.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Jean Grem (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Al B Benson; Emily Chan; Yi-Jen Chen; Michael A Choti; Harry S Cooper; Paul F Engstrom; Peter C Enzinger; Marwan G Fakih; Deborah A Freedman-Cass; Charles S Fuchs; Tanios Bekaii-Saab; Jean L Grem; Steven Hunt; Lucille A Leong; Edward Lin; Michael G Martin; Kilian Salerno May; Mary F Mulcahy; Kate Murphy; Eric Rohren; David P Ryan; Leonard Saltz; Sunil Sharma; David Shibata; John M Skibber; William Small; Constantinos T Sofocleous; Alan P Venook; Christopher G Willett; Kristina M Gregory
Rectal cancer.
Journal of the National Comprehensive Cancer Network : JNCCN 2012;10(12):1528-64.
2012: Al B Benson; Emily Chan; Yi-Jen Chen; Michael A Choti; Harry S Cooper; Raza A Dilawari; Paul F Engstrom; Peter C Enzinger; Marwan G Fakih; James W Fleshman; Deborah A Freedman-Cass; Charles S Fuchs; Jean L Grem; Lucille A Leong; Edward Lin; Kilian Salerno May; Mary F Mulcahy; Kate Murphy; Eric Rohren; David P Ryan; Leonard Saltz; Sunil Sharma; David Shibata; John M Skibber; William Small; Constantinos T Sofocleous; Alan P Venook; Christopher Willett; J Pablo Arnoletti; Tanios Bekaii-Saab
Anal Carcinoma, Version 2.2012: featured updates to the NCCN guidelines.
Journal of the National Comprehensive Cancer Network : JNCCN 2012;10(4):449-54.
2011: Al B Benson; Emily Chan; Yi-Jen Chen; Michael A Choti; Harry S Cooper; Raza A Dilawari; Paul F Engstrom; Peter C Enzinger; James W Fleshman; Charles S Fuchs; Jean L Grem; James A Knol; Lucille A Leong; Edward Lin; Kilian Salerno May; Mary F Mulcahy; Kate Murphy; Eric Rohren; David P Ryan; Leonard Saltz; Sunil Sharma; David Shibata; John M Skibber; William Small; Constantinos T Sofocleous; Alan P Venook; Christopher Willett; J Pablo Arnoletti; Tanios Bekaii-Saab
Colon cancer.
Journal of the National Comprehensive Cancer Network : JNCCN 2011;9(11):1238-90.
2011: Basem M William; Jean L Grem
Brain metastasis and leptomeningeal carcinomatosis in a patient with cholangiocarcinoma.
Gastrointestinal cancer research : GCR 2011;4(4):144-5.
2010: Ann M Berger; Jean L Grem; Constance Visovsky; Heather A Marunda; Justin M Yurkovich
Fatigue and other variables during adjuvant chemotherapy for colon and rectal cancer.
Oncology nursing forum 2010;37(6):E359-69.
2010: Paul F Engstrom; Juan Pablo Arnoletti; Al B Benson; Jordan D Berlin; J Michael Berry; Yi-Jen Chen; Michael A Choti; Harry S Cooper; Raza A Dilawari; Dayna S Early; Peter C Enzinger; Marwan G Fakih; James Fleshman; Charles Fuchs; Jean L Grem; James A Knol; Lucille A Leong; Edward Lin; Mary F Mulcahy; Eric Rohren; David P Ryan; Leonard B Saltz; David Shibata; John M Skibber; William Small; Constantinos T Sofocleous; James P Thomas; Alan P Venook; Christopher Willett
NCCN clinical practice guidelines in oncology. Anal carcinoma.
Journal of the National Comprehensive Cancer Network : JNCCN 2010;8(1):106-20.
2009: Paul F Engstrom; Juan Pablo Arnoletti; Al B Benson; Yi-Jen Chen; Michael A Choti; Harry S Cooper; Anne Covey; Raza A Dilawari; Dayna S Early; Peter C Enzinger; Marwan G Fakih; James Fleshman; Charles Fuchs; Jean L Grem; Krystyna Kiel; James A Knol; Lucille A Leong; Edward Lin; Mary F Mulcahy; Sujata Rao; David P Ryan; Leonard B Saltz; David Shibata; John M Skibber; Constantinos T Sofocleous; James P Thomas; Alan P Venook; Christopher Willett
NCCN Clinical Practice Guidelines in Oncology: rectal cancer.
Journal of the National Comprehensive Cancer Network : JNCCN 2009;7(8):838-81.
2009: Paul F Engstrom; Juan Pablo Arnoletti; Al B Benson; Yi-Jen Chen; Michael A Choti; Harry S Cooper; Anne Covey; Raza A Dilawari; Dayna S Early; Peter C Enzinger; Marwan G Fakih; James Fleshman; Charles Fuchs; Jean L Grem; Krystyna Kiel; James A Knol; Lucille A Leong; Edward Lin; Mary F Mulcahy; Sujata Rao; David P Ryan; Leonard B Saltz; David Shibata; John M Skibber; Constantinos T Sofocleous; James P Thomas; Alan P Venook; Christopher Willett
NCCN Clinical Practice Guidelines in Oncology: colon cancer.
Journal of the National Comprehensive Cancer Network : JNCCN 2009;7(8):778-831.
2009: Michael F Sorrell; Edward A Belongia; Jose Costa; Ilana F Gareen; Jean L Grem; John M Inadomi; Earl R Kern; James A McHugh; Gloria M Petersen; Michael F Rein; Doris B Strader; Hartwell T Trotter
National Institutes of Health consensus development conference statement: management of hepatitis B.
Hepatology (Baltimore, Md.) 2009;49(5 Suppl):S4-S12.
2009: Michael F Sorrell; Edward A Belongia; Jose Costa; Ilana F Gareen; Jean L Grem; John M Inadomi; Earl R Kern; James A McHugh; Gloria M Petersen; Michael F Rein; Doris B Strader; Hartwell T Trotter
National Institutes of Health Consensus Development Conference Statement: management of hepatitis B.
Annals of internal medicine 2009;150(2):104-10.
2008: Joseph Gibbons; Merrill J Egorin; Ramesh K Ramanathan; Pingfu Fu; Daniel Mulkerin; Stephen Shibata; Chris H Takimoto; Sridhar Mani; Patricia M LoRusso; Jean L Grem; Anna Pavlick; Heinz-Josef Lenz; Susan M Flick; Sherrie Reynolds; Theodore F Lagattuta; Robert A Parise; Yanfeng Wang; Anthony J Murgo; S Percy Ivy; Scot C Remick
Phase I and pharmacokinetic study of imatinib mesylate in patients with advanced malignancies and varying degrees of renal dysfunction: a study by the National Cancer Institute Organ Dysfunction Working Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(4):570-6.
2008: Ramesh K Ramanathan; Merrill J Egorin; Chris H Takimoto; Scot C Remick; James Doroshow; Patricia M LoRusso; Daniel Mulkerin; Jean L Grem; Anne Hamilton; Anthony J Murgo; Douglas M Potter; Chandra P Belani; Michael J Hayes; Bin Peng; S Percy Ivy
Phase I and pharmacokinetic study of imatinib mesylate in patients with advanced malignancies and varying degrees of liver dysfunction: a study by the National Cancer Institute Organ Dysfunction Working Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(4):563-9.
2008: Kazumi Uchida; Peter V Danenberg; Kathleen D Danenberg; Jean L Grem
Thymidylate synthase, dihydropyrimidine dehydrogenase, ERCC1, and thymidine phosphorylase gene expression in primary and metastatic gastrointestinal adenocarcinoma tissue in patients treated on a phase I trial of oxaliplatin and capecitabine.
BMC cancer 2008;8():386.
2007: Paul F Engstrom; J Pablo Arnoletti; Al B Benson; Yi-Jen Chen; Michael A Choti; Harry S Cooper; Raza A Dilawari; Dayna S Early; Marwan G Fakih; Charlie S Fuchs; Jean L Grem; Krystyna Kiel; James A Knol; Lucille A Leong; Kirk A Ludwig; Edward W Martin; Sujata Rao; Leonard B Saltz; David Shibata; John M Skibber; Alan P Venook
Rectal cancer.
Journal of the National Comprehensive Cancer Network : JNCCN 2007;5(9):940-81.
2007: Paul F Engstrom; J Pablo Arnoletti; Al B Benson; Yi-Jen Chen; Michael A Choti; Harry S Cooper; Raza A Dilawari; Dayna S Early; Marwan G Fakih; Charlie S Fuchs; Jean L Grem; Krystyna Kiel; James A Knol; Lucille A Leong; Kirk A Ludwig; Edward W Martin; Sujata Rao; Leonard B Saltz; David Shibata; John M Skibber; Alan P Venook
Colon cancer.
Journal of the National Comprehensive Cancer Network : JNCCN 2007;5(9):884-925.
2007: Chris H Takimoto; Martin A Graham; Graham Lockwood; Chee M Ng; Andrew Goetz; Dennis Greenslade; Scot C Remick; Sunil Sharma; Sridhar Mani; Ramesh K Ramanathan; Timothy W Synold; James Doroshow; Anne Hamilton; Daniel Mulkerin; Percy Ivy; Merrill J Egorin; Jean L Grem
Oxaliplatin pharmacokinetics and pharmacodynamics in adult cancer patients with impaired renal function.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(16):4832-9.
2005: Richard G Webster; Keith Brain; Richard H Wilson; Jean L Grem; Angela Vincent
Oxaliplatin induces hyperexcitability at motor and autonomic neuromuscular junctions through effects on voltage-gated sodium channels.
British journal of pharmacology 2005;146(7):1027-39.
2005: Jean L Grem
Screening for dihydropyrimidine dehydrogenase deficiency.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(14):5067-8.
2005: Maurice A Wright; Geraldine Morrison; Pengxin Lin; Gregory D Leonard; Diana Nguyen; Xaiodu Guo; Eva Szabo; Jon L Hopkins; Jorge P Leguizamo; Nancy Harold; Suzanne Fioravanti; Barbara Schuler; Brian P Monahan; Muhammad Wasif Saif; Mary G Quinn; Janet Pang; Jean L Grem
A phase I pharmacologic and pharmacogenetic trial of sequential 24-hour infusion of irinotecan followed by leucovorin and a 48-hour infusion of fluorouracil in adult patients with solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(11):4144-50.
2005: Abdel-Salam Attia Ismail; Mary G Quinn; Maurice A Wright; Aaron Ernst; Vivian Kao; Liam Grogan; Allyson L Parr; Frank Grollman; Ilan R Kirsch; Jean L Grem
A phase II and pharmacologic study of fluorouracil given by a 1-hour infusion daily for 5 days with leucovorin and interferon alpha-2a in adenocarcinoma of the large bowel.
Oncology reports 2005;13(6):1145-52.
2005: Jean L Grem; Geraldine Morrison; Xiao-Du Guo; Elizabeth Agnew; Chris H Takimoto; Rebecca Thomas; Eva Szabo; Louise B. Grochow; Frank Grollman; J Michael Hamilton; Len Neckers; Richard H Wilson
Phase I and pharmacologic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(9):1885-93.
2005: Jean L Grem
Intratumoral molecular or genetic markers as predictors of clinical outcome with chemotherapy in colorectal cancer.
Seminars in oncology 2005;32(1):120-7.
2005: Gregory D Leonard; Maurice A Wright; Mary G Quinn; Suzanne Fioravanti; Nancy Harold; Barbara Schuler; Rebecca R Thomas; Jean L Grem
Survey of oxaliplatin-associated neurotoxicity using an interview-based questionnaire in patients with metastatic colorectal cancer.
BMC cancer 2005;5():116.
2004: Jean L Grem
Adjuvant therapy for colon cancer: a historical perspective.
Journal of the National Cancer Institute 2004;96(15):1116-7.
2004: Gregory D Leonard; Michael R Wagner; Mary G Quinn; Jean L Grem
Severe disabling sensory-motor polyneuropathy during oxaliplatin-based chemotherapy.
Anti-cancer drugs 2004;15(7):733-5.
2004: Jean L Grem
Mature results of adjuvant colon cancer trials from the fluorouracil-only era.
Journal of the National Cancer Institute 2004;96(10):727-9.
2004: Yan Xu; Bruce Keith; Jean L Grem
Measurement of the anticancer agent gemcitabine and its deaminated metabolite at low concentrations in human plasma by liquid chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;802(2):263-70.
2004: Tanya Lehky; Gregory D Leonard; Richard H Wilson; Jean L Grem; Mary Kay Floeter
Oxaliplatin-induced neurotoxicity: acute hyperexcitability and chronic neuropathy.
Muscle & nerve 2004;29(3):387-92.
2003: Patrick J Mansky; Jean L Grem; Dawn B Wallerstedt; Brian P Monahan; Marc R Blackman
Mistletoe and gemcitabine in patients with advanced cancer: a model for the phase I study of botanicals and botanical-drug interactions in cancer therapy.
Integrative cancer therapies 2003;2(4):345-52.
2003: Jean L Grem; Mary G Quinn; Bruce Keith; Brian P Monahan; J Michael Hamilton; Yan Xu; Nancy Harold; Diana Nguyen; Chris H Takimoto; Anthony Rowedder; Janet Pang; Geraldine Morrison; Alice Chen
A phase I and pharmacologic study of weekly gemcitabine in combination with infusional 5-fluorodeoxyuridine and oral calcium leucovorin.
Cancer chemotherapy and pharmacology 2003;52(6):487-96.
2003: Jorge Leguizamo; Mary Quinn; Chris H Takimoto; Michael D Liang; Abdel-Salam Attia Ismail; Janet Pang; William Dahut; Jean L Grem
A phase I study of 9-aminocamptothecin as a colloidal dispersion formulation given as a fortnightly 72-h infusion.
Cancer chemotherapy and pharmacology 2003;52(4):333-8.
2003: Chris H Takimoto; Scot C Remick; Sunil Sharma; Sridhar Mani; Ramesh K Ramanathan; James Doroshow; Anne Hamilton; Daniel Mulkerin; Martin Graham; Graham F Lockwood; Percy Ivy; Merrill J Egorin; Dennis Greenslade; Andrew Goetz; Jean L Grem
Administration of oxaliplatin to patients with renal dysfunction: a preliminary report of the national cancer institute organ dysfunction working group.
Seminars in oncology 2003;30(4 Suppl 15):20-5.
2003: Chris H Takimoto; Scot C Remick; Sunil Sharma; Sridhar Mani; Ramesh K Ramanathan; James Doroshow; Anne Hamilton; Daniel Mulkerin; Martin Graham; Graham F Lockwood; Percy Ivy; Merrill J Egorin; Barbara Schuler; Dennis Greenslade; Andrew Goetz; Ronald Knight; Rebecca Thomas; Brian P Monahan; William Dahut; Jean L Grem
Dose-escalating and pharmacological study of oxaliplatin in adult cancer patients with impaired renal function: a National Cancer Institute Organ Dysfunction Working Group Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(14):2664-72.
2003: Xiao-Du Guo; Nancy Harold; Muhammad Wasif Saif; Barbara Schuler; Eva Szabo; J Michael Hamilton; Brian P Monahan; Mary G Quinn; Janet Cliatt; Diana Nguyen; Frank Grollman; Rebecca R Thomas; Elizabeth A McQuigan; Richard Wilson; Chris H Takimoto; Jean L Grem
Pharmacokinetic and pharmacodynamic effects of oral eniluracil, fluorouracil and leucovorin given on a weekly schedule.
Cancer chemotherapy and pharmacology 2003;52(1):79-85.
2003: Gregory D Leonard; Minocher Battiwalla; John B Stockle; Robert A Harris; Brian P Monahan; Jean L Grem
Extraocular muscle palsy from metastatic prostate cancer.
The lancet oncology 2003;4(6):358.
2003: Rebecca R Thomas; Mary G Quinn; Barbara Schuler; Jean L Grem
Hypersensitivity and idiosyncratic reactions to oxaliplatin.
Cancer 2003;97(9):2301-7.
2003: Maurice A Wright; Barbara Schuler; Eva Szabo; Jean L Grem
Sustained partial response of an intra-abdominal desmoid tumor treated with gemcitabine, 5-fluorouracil and leucovorin.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2003;14(4):659-60.
2003: Bruce Keith; Yan Xu; Jean L Grem
Measurement of the anti-cancer agent gemcitabine in human plasma by high-performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;785(1):65-72.
2003: Yan Xu; Jean L Grem
Liquid chromatography-mass spectrometry method for the analysis of the anti-cancer agent capecitabine and its nucleoside metabolites in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;783(1):273-85.
2003: Muhammad Wasif Saif; Mary G Quinn; Rebecca R Thomas; Aaron Ernst; Jean L Grem
Cardiac toxicity associated with capecitabine therapy.
Acta oncologica (Stockholm, Sweden) 2003;42(4):342-4.
2002: Gregory D Leonard; Sen H Zhuang; Jean L Grem
Epirubicin, Cisplatin, and protracted venous-infusion Fluorouracil in advanced esophagogastric cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(19):4124-5; author reply 4125-6.
2002: Jean L Grem; Nancy Harold; Bruce Keith; Alice P Chen; Vivian Kao; Chris H Takimoto; J Michael Hamilton; Janet Pang; Marie Pace; Gada B Jasser; Mary G Quinn; Brian P Monahan
A phase I pharmacologic and pharmacodynamic study of pyrazoloacridine given as a weekly 24-hour continuous intravenous infusion in adult cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2149-56.
2002: Bruce Keith; Xiao-Du Guo; Suzanne Zentko; Nancy Harold; Barbara Schuler; Mary Quinn; Jeremy Shapiro; Jean L Grem
Impact of two weekly schedules of oral eniluracil given with fluorouracil and leucovorin on the duration of dihydropyrimidine dehydrogenase inhibition.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(5):1045-50.
2002: Richard H Wilson; Tanya Lehky; Rebecca R Thomas; Mary G Quinn; Mary Kay Floeter; Jean L Grem
Acute oxaliplatin-induced peripheral nerve hyperexcitability.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(7):1767-74.
2002: Jean L Grem; Kathleen D Danenberg; Vivian Kao; Peter V Danenberg; Diana Nguyen
Biochemical and molecular effects of UCN-01 in combination with 5-fluorodeoxyuridine in A431 human epidermoid cancer cells.
Anti-cancer drugs 2002;13(3):259-70.
2002: Dennis Salonga; Kathleen D Danenberg; Jean L Grem; Ji Min Park; Peter V Danenberg
Relative gene expression in normal and tumor tissue by quantitative RT-PCR.
Methods in molecular biology (Clifton, N.J.) 2002;191():83-98.
2001: Jean L Grem; LK Yee; Barbara Schuler; J Michael Hamilton; Alice P Chen; C Chabuk; Frank Grollman; M Grabenc; Carmen J Allegra; Chris H Takimoto
N-(phosphonacetyl)-L-aspartate and calcium leucovorin modulation of fluorouracil administered by constant rate and circadian pattern of infusion over 72 hours in metastatic gastrointestinal adenocarcinoma.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2001;12(11):1581-7.
2001: Rebecca R Thomas; William Dahut; Nancy Harold; Jean L Grem; Brian P Monahan; M Liang; RA Band; John R Cottrell; Victor Llorens; J A Smith; W Corse; Arbuck Susan; J Wright; Alice P Chen; JD Shapiro; J Michael Hamilton; Carmen J Allegra; Chris H Takimoto
A phase I and pharmacologic study of 9-aminocamptothecin administered as a 120-h infusion weekly to adult cancer patients.
Cancer chemotherapy and pharmacology 2001;48(3):215-22.
2001: Muhammad Wasif Saif; R H Wilson; Nancy Harold; Bruce Keith; D S Dougherty; Jean L Grem
Peripheral neuropathy associated with weekly oral 5-fluorouracil, leucovorin and eniluracil.
Anti-cancer drugs 2001;12(6):525-31.
2001: E B Agnew; Richard H Wilson; Jean L Grem; Len Neckers; DQ Bi; Chris H Takimoto
Measurement of the novel antitumor agent 17-(allylamino)-17-demethoxygeldanamycin in human plasma by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 2001;755(1-2):237-43.
2001: A A Guemei; John R Cottrell; RA Band; H Hehman; M Prudhomme; M V Pavlov; Jean L Grem; Abdel-Salam Attia Ismail; D Bowen; R E Taylor; Chris H Takimoto
Human plasma carboxylesterase and butyrylcholinesterase enzyme activity: correlations with SN-38 pharmacokinetics during a prolonged infusion of irinotecan.
Cancer chemotherapy and pharmacology 2001;47(4):283-90.
2001: Jean L Grem; K D Danenberg; Katie Behan; Allyson L Parr; L Young; P V Danenberg; Diana Nguyen; J Drake; Anne Monks; Carmen J Allegra
Thymidine kinase, thymidylate synthase, and dihydropyrimidine dehydrogenase profiles of cell lines of the National Cancer Institute's Anticancer Drug Screen.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(4):999-1009.
2001: Abdel-Salam Attia Ismail; Jean L Grem
Thymidylate synthase inhibitors.
Cancer chemotherapy and biological response modifiers 2001;19():1-19.
2001: Jean L Grem; Mary Quinn; Abdel-Salam Attia Ismail; Chris H Takimoto; Richard M Lush; David J Liewehr; Seth M Steinberg; FRANK BALIS; Alice P Chen; Brian P Monahan; Nancy Harold; W Corse; Janet Pang; RF Murphy; Carmen J Allegra; J Michael Hamilton
Pharmacokinetics and pharmacodynamic effects of 5-fluorouracil given as a one-hour intravenous infusion.
Cancer chemotherapy and pharmacology 2001;47(2):117-25.
2001: Jean L Grem
Biochemical modulation of 5-FU in systemic treatment of advanced colorectal cancer.
Oncology (Williston Park, N.Y.) 2001;15(1 Suppl 2):13-9.
2000: Jean L Grem; Nancy Harold; Jeremy Shapiro; DQ Bi; Mary G Quinn; Suzanne Zentko; Bruce Keith; J Michael Hamilton; Brian P Monahan; S Donavan; Frank Grollman; Geraldine Morrison; Chris H Takimoto
Phase I and pharmacokinetic trial of weekly oral fluorouracil given with eniluracil and low-dose leucovorin to patients with solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(23):3952-63.
2000: DQ Bi; L W Anderson; Jeremy Shapiro; A Shapiro; Jean L Grem; Chris H Takimoto
Measurement of plasma uracil using gas chromatography-mass spectrometry in normal individuals and in patients receiving inhibitors of dihydropyrimidine dehydrogenase.
Journal of chromatography. B, Biomedical sciences and applications 2000;738(2):249-58.
2000: Chris H Takimoto; Geraldine Morrison; Nancy Harold; Mary Quinn; Brian P Monahan; RA Band; John R Cottrell; A Guemei; Victor Llorens; H Hehman; Abdel-Salam Attia Ismail; D Flemming; David Gosky; H Hirota; Sosamma J Berger; Nathan A Berger; Alice P Chen; JD Shapiro; Arbuck Susan; J Wright; J Michael Hamilton; Carmen J Allegra; Jean L Grem
Phase I and pharmacologic study of irinotecan administered as a 96-hour infusion weekly to adult cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(3):659-67.
2000: Donna Voeller; Jean L Grem; Y Pommier; K Paull; Carmen J Allegra
Identification and proposed mechanism of action of thymidine kinase inhibition associated with cellular exposure to camptothecin analogs.
Cancer chemotherapy and pharmacology 2000;45(5):409-16.
1999: JD Shapiro; Nancy Harold; Chris H Takimoto; J Michael Hamilton; David Vaughn; Alice Chen; Seth M Steinberg; David J Liewehr; Carmen J Allegra; Brian P Monahan; Alex E Lash; Frank Grollman; D Flemming; Katie Behan; Patrick G Johnston; Daniel Haller; Mary Quinn; Geraldine Morrison; Jean L Grem
A pilot study of interferon alpha-2a, fluorouracil, and leucovorin given with granulocyte-macrophage colony stimulating factor in advanced gastrointestinal adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(9):2399-408.
1999: Jean L Grem; JM Sorensen; E Cullen; Chris H Takimoto; Seth M Steinberg; Alice P Chen; J Michael Hamilton; Arbuck Susan; N McAtee; D Lawrence; Barry Goldspiel; Patrick G Johnston; Carmen J Allegra
A Phase I study of raltitrexed, an antifolate thymidylate synthase inhibitor, in adult patients with advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(9):2381-91.
1999: Jean L Grem; Diana Nguyen; Brian P Monahan; Vivian Kao; FJ Geoffroy
Sequence-dependent antagonism between fluorouracil and paclitaxel in human breast cancer cells.
Biochemical pharmacology 1999;58(3):477-86.
1999: Chris H Takimoto; LK Yee; David J Venzon; Barbara Schuler; Frank Grollman; C Chabuk; J Michael Hamilton; Alice P Chen; Carmen J Allegra; Jean L Grem
High inter- and intrapatient variation in 5-fluorouracil plasma concentrations during a prolonged drug infusion.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(6):1347-52.
1999: Jean L Grem; C H Takimoto; P Multani; E Chu; D Ryan; Bruce A Chabner; C J Allegra; P G Johnston
Antimetabolites.
Cancer chemotherapy and biological response modifiers 1999;18():1-38.
1998: Norman Wolmark; John Bryant; Roy Smith; Jean L Grem; Carmen J Allegra; DM Hyams; J Atkins; NV Dimitrov; R Oishi; Diane Prager; Louis Fehrenbacher; Edward Romond; Linda H Colangelo; Bernard Fisher
Adjuvant 5-fluorouracil and leucovorin with or without interferon alfa-2a in colon carcinoma: National Surgical Adjuvant Breast and Bowel Project protocol C-05.
Journal of the National Cancer Institute 1998;90(23):1810-6.
1998: Q Ren; Vivian Kao; Jean L Grem
Cytotoxicity and DNA fragmentation associated with sequential gemcitabine and 5-fluoro-2'-deoxyuridine in HT-29 colon cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(11):2811-8.
1998: Jean L Grem; Seth M Steinberg; Alice P Chen; N McAtee; E Cullen; J Michael Hamilton; Carmen J Allegra
The utility of monitoring carcinoembyronic antigen during systemic therapy for advanced colorectal cancer.
Oncology reports 1998;5(3):559-67.
1998: A Ismail; Cees J van Groeningen; Anthea Hardcastle; Q Ren; G Wynne Aherne; FJ Geoffroy; Carmen J Allegra; Jean L Grem
Modulation of fluorouracil cytotoxicity by interferon-alpha and -gamma.
Molecular pharmacology 1998;53(2):252-61.
1998: Jean L Grem
Recent insights into the molecular basis of intrinsic resistance of colorectal cancer: new challenges for systemic therapeutic approaches.
Cancer treatment and research 1998;98():293-338.
1997: Jean L Grem
Systemic treatment options in advanced colorectal cancer: perspectives on combination 5-fluorouracil plus leucovorin.
Seminars in oncology 1997;24(5 Suppl 18):S18-8-S18-18.
1997: Jean L Grem; N McAtee; RF Murphy; FRANK BALIS; E Cullen; Alice P Chen; J Michael Hamilton; Seth M Steinberg; Mary Quinn; JM Sorensen; Arbuck Susan; D Lawrence; Janet Pang; Carmen J Allegra
A pilot study of gamma-1b-interferon in combination with fluorouracil, leucovorin, and alpha-2a-interferon.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(7):1125-34.
1997: Chris H Takimoto; William Dahut; M T Marino; H Nakashima; M D Liang; Nancy Harold; Richard W Lieberman; Arbuck Susan; RA Band; Alice P Chen; J Michael Hamilton; L R Cantilena; Carmen J Allegra; Jean L Grem
Pharmacodynamics and pharmacokinetics of a 72-hour infusion of 9-aminocamptothecin in adult cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(4):1492-501.
1997: P G Johnston; C H Takimoto; Jean L Grem; Panos Fidias; M L Grossbard; Bruce A Chabner; C J Allegra; E Chu
Antimetabolites.
Cancer chemotherapy and biological response modifiers 1997;17():1-39.
1997: Jean L Grem; LK Yee; David J Venzon; Chris H Takimoto; Carmen J Allegra
Inter- and intraindividual variation in dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells.
Cancer chemotherapy and pharmacology 1997;40(2):117-25.
1997: Q Ren; Cees J van Groeningen; Anthea Hardcastle; G Wynne Aherne; FJ Geoffroy; Carmen J Allegra; Patrick G Johnston; Jean L Grem
Determinants of cytotoxicity with prolonged exposure to fluorouracil in human colon cancer cells.
Oncology research 1997;9(2):77-88.
1996: Chris H Takimoto; William Dahut; Nancy Harold; H Nakashima; Ronald Lieberman; M D Liang; Arbuck Susan; Alice P Chen; J Michael Hamilton; L R Cantilena; Carmen J Allegra; Jean L Grem
Clinical pharmacology of 9-aminocamptothecin.
Annals of the New York Academy of Sciences 1996;803():324-6.
1996: Patrick G Johnston; F Geoffrey; J Drake; D Voeller; Jean L Grem; Carmen J Allegra
The cellular interaction of 5-fluorouracil and cisplatin in a human colon carcinoma cell line.
European journal of cancer (Oxford, England : 1990) 1996;32A(12):2148-54.
1996: Jean L Grem; P M Politi; S L Berg; N M Benchekroun; M Patel; FRANK BALIS; B K Sinha; William Dahut; Carmen J Allegra
Cytotoxicity and DNA damage associated with pyrazoloacridine in MCF-7 breast cancer cells.
Biochemical pharmacology 1996;51(12):1649-59.
1996: B Yu; Jorge Carrasquillo; Diane E Milenic; Y Chung; P Perentesis; I Feuerestein; D Eggensperger; C F Qi; Chang H Paik; J Reynolds; Jean L Grem; G Curt; K Siler; Jeffrey Schlom; Carmen J Allegra
Phase I trial of iodine 131-labeled COL-1 in patients with gastrointestinal malignancies: influence of serum carcinoembryonic antigen and tumor bulk on pharmacokinetics.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(6):1798-809.
1996: William Dahut; Nancy Harold; Chris H Takimoto; Carmen J Allegra; A Chen; J Michael Hamilton; Arbuck Susan; M Sorensen; Frank Grollman; H Nakashima; Ronald Lieberman; M Liang; W Corse; Jean L Grem
Phase I and pharmacologic study of 9-aminocamptothecin given by 72-hour infusion in adult cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(4):1236-44.
1996: Chris H Takimoto; Z H Lu; R Zhang; M D Liang; L V Larson; L R Cantilena; Jean L Grem; Carmen J Allegra; R B Diasio; Edward Chu
Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(3):477-81.
1996: Edward Chu; Jean L Grem; Patrick G Johnston; Carmen J Allegra
New concepts for the development and use of antifolates.
Stem cells (Dayton, Ohio) 1996;14(1):41-6.
1996: Patrick G Johnston; Chris H Takimoto; Jean L Grem; B A Chabner; Carmen J Allegra; Edward Chu
Antimetabolites.
Cancer chemotherapy and biological response modifiers 1996;16():1-27.
1995: F Geoffroy; William Dahut; Chris H Takimoto; Jean L Grem
Effects of 9-aminocamptothecin on newly synthesized DNA in patient bone marrow samples.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(11):1345-51.
1995: Jean L Grem; F Geoffroy; P M Politi; D P Cuddy; Douglas Ross; D Nguyen; Seth M Steinberg; Carmen J Allegra
Determinants of sensitivity to 1-beta-D-arabinofuranosylcytosine in HCT 116 and NCI-H630 human colon carcinoma cells.
Molecular pharmacology 1995;48(2):305-15.
1995: H Richard Alexander; Jean L Grem; J Michael Hamilton; Harvey I Pass; M Hong; Douglas L Fraker; Seth M Steinberg; N McAtee; B C Allegra; Patrick G Johnston
Thymidylate synthase protein expression: Association with response to neoadjuvant chemotherapy and resection for locally advanced gastric and gastroesophageal adenocarcinoma.
The cancer journal from Scientific American 1995;1(1):49-54.
1994: Jean L Grem; D M Voeller; F Geoffroy; E Horak; Patrick G Johnston; Carmen J Allegra
Determinants of trimetrexate lethality in human colon cancer cells.
British journal of cancer 1994;70(6):1075-84.
1994: Jean L Grem; P Daychild; J Drake; F Geoffroy; Jane Trepel; F Pirnia; Carmen J Allegra
Cytotoxicity and metabolism of 4-methoxy-8-(beta-D-ribofuranosylamino)pyrimido[5,4-d]pyrimidine in HCT 116 colon cancer cells.
Biochemical pharmacology 1994;48(11):2117-26.
1994: F Geoffroy; Jean L Grem
Chemotherapy of advanced gastrointestinal cancer.
Current opinion in oncology 1994;6(4):427-34.
1994: Chris H Takimoto; Raymond W Klecker; William Dahut; L K Yee; John M Strong; Carmen J Allegra; Jean L Grem
Analysis of the active lactone form of 9-aminocamptothecin in plasma using solid-phase extraction and high-performance liquid chromatography.
Journal of chromatography. B, Biomedical applications 1994;655(1):97-104.
1994: Jean L Grem; N McAtee; RF Murphy; J Michael Hamilton; FRANK BALIS; S Steinberg; Arbuck Susan; A Setser; E Jordan; A Chen
Phase I and pharmacokinetic study of recombinant human granulocyte-macrophage colony-stimulating factor given in combination with fluorouracil plus calcium leucovorin in metastatic gastrointestinal adenocarcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1994;12(3):560-8.
1994: F J Geoffroy; Carmen J Allegra; B Sinha; Jean L Grem
Enhanced cytotoxicity with interleukin-1 alpha and 5-fluorouracil in HCT116 colon cancer cells.
Oncology research 1994;6(12):581-91.
1994: Edward Chu; Patrick G Johnston; Jean L Grem; Chris H Takimoto; C Van Groeningen; B A Chabner; Carmen J Allegra
Antimetabolites.
Cancer chemotherapy and biological response modifiers 1994;15():1-31.
1993: Jean L Grem; N McAtee; Seth M Steinberg; J Michael Hamilton; RF Murphy; J Drake; T Chisena; FRANK BALIS; R Cysyk; Arbuck Susan
A phase I study of continuous infusion 5-fluorouracil plus calcium leucovorin in combination with N-(phosphonacetyl)-L-aspartate in metastatic gastrointestinal adenocarcinoma.
Cancer research 1993;53(20):4828-36.
1993: Jean L Grem; E Jordan; Mark Robson; R A Binder; J Michael Hamilton; Seth M Steinberg; Arbuck Susan; R A Beveridge; A N Kales; J A Miller
Phase II study of fluorouracil, leucovorin, and interferon alfa-2a in metastatic colorectal carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1993;11(9):1737-45.
1993: Riad Agbaria; Harry Ford; James A Kelley; F Xie; P Politi; Jean L Grem; D A Cooney; Victor E Marquez; Carmen J Allegra; David G Johns
Measurement of cyclopentenyl cytosine 5'-triphosphate in vitro and in vivo by multidimensional high-performance liquid chromatography.
Analytical biochemistry 1993;213(1):90-6.
1993: Jean L Grem; N McAtee; FRANK BALIS; R Murphy; David Venzon; B Kramer; Barry Goldspiel; M Begley; Carmen J Allegra
A phase II study of continuous infusion 5-fluorouracil and leucovorin with weekly cisplatin in metastatic colorectal carcinoma.
Cancer 1993;72(3):663-8.
1993: Edward Chu; Chris H Takimoto; D Voeller; Jean L Grem; Carmen J Allegra
Specific binding of human dihydrofolate reductase protein to dihydrofolate reductase messenger RNA in vitro.
Biochemistry 1993;32(18):4756-60.
1993: H Richard Alexander; Jean L Grem; Harvey I Pass; M Hamilton; N McAtee; Douglas L Fraker; Carmen J Allegra
Neoadjuvant chemotherapy for locally advanced gastric adenocarcinoma.
Oncology (Williston Park, N.Y.) 1993;7(5):37-42; discussion 42-4, 49-50, 53.
1993: Edward Chu; Patrick G Johnston; Chris H Takimoto; P M Politi; Jean L Grem; B A Chabner; Carmen J Allegra
Antimetabolites.
Cancer chemotherapy and biological response modifiers 1993;14():1-25.
1993: Jean L Grem; N McAtee; J C Drake; S Steinberg; Carmen J Allegra
Dose-dependent inhibition of aspartate carbamoyltransferase in peripheral blood mononuclear cells in patients receiving N-(phosphonacetyl)-L-aspartate.
Advances in experimental medicine and biology 1993;339():119-23.
1992: L K Yee; Carmen J Allegra; Seth M Steinberg; Jean L Grem
Decreased catabolism of fluorouracil in peripheral blood mononuclear cells during combination therapy with fluorouracil, leucovorin, and interferon alpha-2a.
Journal of the National Cancer Institute 1992;84(23):1820-5.
1992: Alice P Chen; Jean L Grem
Antimetabolites.
Current opinion in oncology 1992;4(6):1089-98.
1992: L K Yee; Carmen J Allegra; Jane Trepel; Jean L Grem
Metabolism and RNA incorporation of cyclopentenyl cytosine in human colorectal cancer cells.
Biochemical pharmacology 1992;43(7):1587-99.
1992: Jean L Grem
Biochemical modulation of fluorouracil by dipyridamole: preclinical and clinical experience.
Seminars in oncology 1992;19(2 Suppl 3):56-65.
1992: Jean L Grem; Edward Chu; D Boarman; FRANK BALIS; RF Murphy; N McAtee; Carmen J Allegra
Biochemical modulation of fluorouracil with leucovorin and interferon: preclinical and clinical investigations.
Seminars in oncology 1992;19(2 Suppl 3):36-44.
1992: Edward Chu; Jean L Grem; Patrick G Johnston; P M Politi; B A Chabner; Carmen J Allegra
Antimetabolites.
Cancer chemotherapy and biological response modifiers 1992;13():1-30.
1991: Jean L Grem; S A King; H G Chun; Michael R Grever
Cardiac complications observed in elderly patients following 2'-deoxycoformycin therapy.
American journal of hematology 1991;38(3):245-7.
1991: Jean L Grem; N McAtee; RF Murphy; FRANK BALIS; Seth M Steinberg; J Michael Hamilton; JM Sorensen; Oliver Sartor; B S Kramer; L J Goldstein
A pilot study of interferon alfa-2a in combination with fluorouracil plus high-dose leucovorin in metastatic gastrointestinal carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1991;9(10):1811-20.
1991: Jean L Grem; S A King; JM Sorensen; Michaele C Christian
Clinical use of thymidine as a rescue agent from methotrexate toxicity.
Investigational new drugs 1991;9(3):281-90.
1991: Jean L Grem; Carmen J Allegra
Sequence-dependent interaction of 5-fluorouracil and arabinosyl-5-azacytosine or 1-beta-D-arabinofuranosylcytosine.
Biochemical pharmacology 1991;42(2):409-18.
1991: Jean L Grem
Current treatment approaches in colorectal cancer.
Seminars in oncology 1991;18(1 Suppl 1):17-26.
1991: Jean L Grem; J Plowman; Lawrence V Rubinstein; M J Hawkins; S D Harrison
Modulation of cytosine arabinoside toxicity by 3-deazauridine in a murine leukemia model.
Leukemia research 1991;15(4):229-36.
1990: Jean L Grem; Carmen J Allegra
Enhancement of the toxicity and DNA incorporation of arabinosyl-5-azacytosine and 1-beta-D-arabinofuranosylcytosine by cyclopentenyl cytosine.
Cancer research 1990;50(22):7279-84.
1990: Jean L Grem
Levamisole as a therapeutic agent for colorectal carcinoma.
Cancer cells (Cold Spring Harbor, N.Y. : 1989) 1990;2(5):131-7.
1990: Jean L Grem; Lawrence V Rubinstein; S A King; Bruce D Cheson; M J Hawkins; D D Shoemaker
Clinical toxicity associated with tiazofurin.
Investigational new drugs 1990;8(2):227-38.
1990: Jean L Grem; S A King; M E Costanza; T D Brown
Hypersensitivity reactions to trimetrexate.
Investigational new drugs 1990;8(2):211-4.
1990: Jean L Grem
5-Fluorouracil and levamisole in colorectal carcinoma.
Cancer investigation 1990;8(2):283-4.
1990: G S Ahluwalia; Jean L Grem; Z Hao; D A Cooney
Metabolism and action of amino acid analog anti-cancer agents.
Pharmacology & therapeutics 1990;46(2):243-71.
1989: S Durrleman; Jean L Grem; Bruce D Cheson
2'-Deoxycoformycin after failure of alpha-interferon in hairy cell leukemia.
European journal of haematology 1989;43(4):297-302.
1989: Jean L Grem; Carmen J Allegra
Toxicity of levamisole and 5-fluorouracil in human colon carcinoma cells.
Journal of the National Cancer Institute 1989;81(18):1413-7.
1989: Jean L Grem; S A King; Bruce D Cheson; Brian Leyland-Jones; R E Wittes
Pentostatin in hairy cell leukemia: treatment by the special exception mechanism.
Journal of the National Cancer Institute 1989;81(6):448-53.
1989: Peter J O'Dwyer; S A King; E Eisenhauer; Jean L Grem; D F Hoth
Hypersensitivity reactions to deoxycoformycin.
Cancer chemotherapy and pharmacology 1989;23(3):173-5.
1989: Jean L Grem; P H Fischer
Enhancement of 5-fluorouracil's anticancer activity by dipyridamole.
Pharmacology & therapeutics 1989;40(3):349-71.
1988: Jean L Grem; S S Ellenberg; S A King; D D Shoemaker
Correlates of severe or life-threatening toxic effects from trimetrexate.
Journal of the National Cancer Institute 1988;80(16):1313-8.
1988: Jean L Grem; Bruce D Cheson; S A King; Brian Leyland-Jones; M Suffness
Cephalotaxine esters: antileukemic advance or therapeutic failure?
Journal of the National Cancer Institute 1988;80(14):1095-103.
1988: Jean L Grem; S A King; Peter J O'Dwyer; Brian Leyland-Jones
Biochemistry and clinical activity of N-(phosphonacetyl)-L-aspartate: a review.
Cancer research 1988;48(16):4441-54.
1988: Jean L Grem; S A King; R E Wittes; Brian Leyland-Jones
The role of methotrexate in osteosarcoma.
Journal of the National Cancer Institute 1988;80(9):626-55.
1988: Jean L Grem; D F Hoth; Brian Leyland-Jones; S A King; R S Ungerleider; Robert Wittes
Teniposide in the treatment of leukemia: a case study of conflicting priorities in the development of drugs for fatal diseases.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1988;6(2):351-79.
1987: Jean L Grem; D F Hoth; J Michael Hamilton; S A King; Brian Leyland-Jones
Overview of current status and future direction of clinical trials with 5-fluorouracil in combination with folinic acid.
Cancer treatment reports 1987;71(12):1249-64.
1987: Jean L Grem; D D Shoemaker; D F Hoth; S A King; J Plowman; D Zaharko; C K Grieshaber; S D Harrison; J C Cradock; Brian Leyland-Jones
Arabinosyl-5-azacytosine: a novel nucleoside entering clinical trials.
Investigational new drugs 1987;5(4):315-28.