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Thierry Grémeaux

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Jennifer Jager; V Corcelle; Thierry Grémeaux; K Laurent; A Waget; G Pagès; B Binétruy; Yannick Le Marchand-Brustel; R Burcelin; F Bost; J F Tanti
Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity.
Jennifer Jager; Thierry Grémeaux; Teresa Gonzalez; Stéphanie Bonnafous; Cyrille Debard; Martine Laville; Hubert Vidal; Albert Tran; Philippe Gual; Yannick Le Marchand-Brustel; Mireille Cormont; Jean-François Tanti
Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.
Vincent Kaddai; Teresa Gonzalez; Frédérique Keslair; Thierry Grémeaux; Stéphanie Bonnafous; Jean Gugenheim; Albert Tran; Philippe Gual; Yannick Le Marchand-Brustel; Mireille Cormont
Rab4b is a small GTPase involved in the control of the glucose transporter GLUT4 localization in adipocyte.

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All Publications

2011: Jennifer Jager; V Corcelle; Thierry Grémeaux; K Laurent; A Waget; G Pagès; B Binétruy; Yannick Le Marchand-Brustel; R Burcelin; F Bost; J F Tanti
Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity.
Diabetologia 2011;54(1):180-9.
2010: Jennifer Jager; Thierry Grémeaux; Teresa Gonzalez; Stéphanie Bonnafous; Cyrille Debard; Martine Laville; Hubert Vidal; Albert Tran; Philippe Gual; Yannick Le Marchand-Brustel; Mireille Cormont; Jean-François Tanti
Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.
Diabetes 2010;59(1):61-70.
2009: Vincent Kaddai; Teresa Gonzalez; Frédérique Keslair; Thierry Grémeaux; Stéphanie Bonnafous; Jean Gugenheim; Albert Tran; Philippe Gual; Yannick Le Marchand-Brustel; Mireille Cormont
Rab4b is a small GTPase involved in the control of the glucose transporter GLUT4 localization in adipocyte.
PloS one 2009;4(4):e5257.
2009: Claire Regazzetti; Pascal Peraldi; Thierry Grémeaux; Rosanna Najem-Lendom; Issam Ben-Sahra; Mireille Cormont; Frédéric Bost; Yannick Le Marchand-Brustel; Jean-François Tanti; Sophie Giorgetti-Peraldi
Hypoxia decreases insulin signaling pathways in adipocytes.
Diabetes 2009;58(1):95-103.
2007: Jennifer Jager; Thierry Grémeaux; Mireille Cormont; Yannick Le Marchand-Brustel; Jean-François Tanti
Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression.
Endocrinology 2007;148(1):241-51.
2006: Romain Barrès; Thierry Grémeaux; Philippe Gual; Teresa Gonzalez; Jean Gugenheim; Albert Tran; Yannick Le Marchand-Brustel; Jean-François Tanti
Enigma interacts with adaptor protein with PH and SH2 domains to control insulin-induced actin cytoskeleton remodeling and glucose transporter 4 translocation.
Molecular endocrinology (Baltimore, Md.) 2006;20(11):2864-75.
2006: Yannick Le Marchand-Brustel; Philippe Gual; Myriam Aouadi; Thierry Grémeaux; Bernard Binétruy; Frédéric Bost; Jean-François Tanti
[Obesity, diabetes and insulin resistance. Alterations of insulin signalling].
Journal de la Société de biologie 2006;200(1):93-7.
2005: Claude Knauf; Patrice Cani; Christophe Perrin; Miguel A Iglesias; Jean François Maury; Elodie Bernard; Fadila Benhamed; Thierry Grémeaux; Daniel J Drucker; C Ronald Kahn; JEAN R GIRARD; Jean-François Tanti; Nathalie M Delzenne; Catherine Postic; Rémy Burcelin
Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage.
The Journal of clinical investigation 2005;115(12):3554-63.
2004: Jean-François Tanti; Philippe Gual; Thierry Grémeaux; Teresa Gonzalez; Romain Barrès; Yannick Le Marchand-Brustel
Alteration in insulin action: role of IRS-1 serine phosphorylation in the retroregulation of insulin signalling.
Annales d'endocrinologie 2004;65(1):43-8.
2003: Yannick Le Marchand-Brustel; Philippe Gual; Thierry Grémeaux; Teresa Gonzalez; Romain Barrès; Jean-François Tanti
Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling.
Biochemical Society transactions 2003;31(Pt 6):1152-6.
2003: Philippe Gual; Thierry Grémeaux; Teresa Gonzalez; Yannick Le Marchand-Brustel; Jean-François Tanti
MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632.
Diabetologia 2003;46(11):1532-42.
2003: Philippe Gual; Teresa Gonzalez; Thierry Grémeaux; Romain Barres; Yannick Le Marchand-Brustel; Jean-François Tanti
Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes.
The Journal of biological chemistry 2003;278(29):26550-7.
2002: Philippe Gual; Satoshi Shigematsu; Makoto Kanzaki; Thierry Grémeaux; Teresa Gonzalez; Jeffrey Pessin; Yannick Le Marchand-Brustel; Jean-François Tanti
A Crk-II/TC10 signaling pathway is required for osmotic shock-stimulated glucose transport.
The Journal of biological chemistry 2002;277(46):43980-6.
2002: Yannick Le Marchand-Brustel; Jean-François Tanti; Thierry Grémeaux; Jean-Marc Ricort
Molecular mechanism of insulin resistance.
Annales d'endocrinologie 2002;63(2 Pt 1):111-3.
2001: Jean-François Tanti; Mireille Cormont; Thierry Grémeaux; Yannick Le Marchand-Brustel
Assays of glucose entry, glucose transporter amount, and translocation.
Methods in molecular biology (Clifton, N.J.) 2001;155():157-65.
2000: Sophie Grillo; Thierry Grémeaux; Antonio Casamayor; Dario R Alessi; Yannick Le Marchand-Brustel; Jean-François Tanti
Peroxovanadate induces tyrosine phosphorylation of phosphoinositide-dependent protein kinase-1 potential involvement of src kinase.
European journal of biochemistry / FEBS 2000;267(22):6642-9.
1999: Sophie Grillo; Thierry Grémeaux; Yannick Le Marchand-Brustel; Jean-François Tanti
Potential role of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in insulin-stimulated glucose transporter 4 translocation in adipocytes.
FEBS letters 1999;461(3):277-9.
1999: Yannick Le Marchand-Brustel; Jean-François Tanti; Mireille Cormont; Jean-Marc Ricort; Thierry Grémeaux; Sophie Grillo
From insulin receptor signalling to Glut 4 translocation abnormalities in obesity and insulin resistance.
Journal of receptor and signal transduction research 1999;19(1-4):217-28.
1997: Jean-François Tanti; Sophie Grillo; Thierry Grémeaux; P J Coffer; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Potential role of protein kinase B in glucose transporter 4 translocation in adipocytes.
Endocrinology 1997;138(5):2005-10.
1997: C Henry; Jean-François Tanti; Thierry Grémeaux; C Morin; Emmanuel Van Obberghen; M Comet; Yannick Le Marchand-Brustel
Characterization of 6-deoxy-6-iodo-D-glucose: a potential new tool to assess glucose transport.
Nuclear medicine and biology 1997;24(1):99-104.
1996: Jean-François Tanti; Thierry Grémeaux; Sophie Grillo; V Calleja; A Klippel; L T Williams; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Overexpression of a constitutively active form of phosphatidylinositol 3-kinase is sufficient to promote Glut 4 translocation in adipocytes.
The Journal of biological chemistry 1996;271(41):25227-32.
1994: Jean-François Tanti; Thierry Grémeaux; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase.
The Biochemical journal 1994;304 ( Pt 1)():17-21.
1994: Jean-François Tanti; Thierry Grémeaux; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.
The Journal of biological chemistry 1994;269(8):6051-7.
1993: D Jullien; Jean-François Tanti; S J Heydrick; N Gautier; Thierry Grémeaux; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Differential effects of okadaic acid on insulin-stimulated glucose and amino acid uptake and phosphatidylinositol 3-kinase activity.
The Journal of biological chemistry 1993;268(20):15246-51.
1993: Jean-François Tanti; Thierry Grémeaux; Mireille Cormont; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Okadaic acid stimulates IGF-II receptor translocation and inhibits insulin action in adipocytes.
The American journal of physiology 1993;264(6 Pt 1):E868-73.
1991: Mireille Cormont; Jean-François Tanti; Thierry Grémeaux; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Subcellular distribution of low molecular weight guanosine triphosphate-binding proteins in adipocytes: colocalization with the glucose transporter Glut 4.
Endocrinology 1991;129(6):3343-50.
1991: Jean-François Tanti; Thierry Grémeaux; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Effects of okadaic acid, an inhibitor of protein phosphatases-1 and -2A, on glucose transport and metabolism in skeletal muscle.
The Journal of biological chemistry 1991;266(4):2099-103.
1990: Yannick Le Marchand-Brustel; C Olichon-Berthe; Thierry Grémeaux; Jean-François Tanti; N Rochet; Emmanuel Van Obberghen
Glucose transporter in insulin sensitive tissues of lean and obese mice. Effect of the thermogenic agent BRL 26830A.
Endocrinology 1990;127(6):2687-95.
1990: Yannick Le Marchand-Brustel; N Rochet; Thierry Grémeaux; I Marot; Emmanuel Van Obberghen
Effect of an alpha-glycosidase inhibitor on experimentally-induced obesity in mice.
Diabetologia 1990;33(1):24-30.
1989: Yannick Le Marchand-Brustel; Robert Ballotti; Thierry Grémeaux; Jean-François Tanti; D Brandenburg; Emmanuel Van Obberghen
Functional labeling of insulin receptor subunits in live cells. Alpha 2 beta 2 species is the major autophosphorylated form.
The Journal of biological chemistry 1989;264(35):21316-21.
1989: Jean-François Tanti; N Rochet; Thierry Grémeaux; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Insulin-stimulated glucose transport in muscle. Evidence for a protein-kinase-C-dependent component which is unaltered in insulin-resistant mice.
The Biochemical journal 1989;258(1):141-6.
1989: Yannick Le Marchand-Brustel; Jean-François Tanti; N Rochet; Thierry Grémeaux; Emmanuel Van Obberghen
[Mechanisms of insulin resistance].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1989;():175-84.
1988: N Rochet; Jean-François Tanti; Thierry Grémeaux; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Effect of a thermogenic agent, BRL 26830A, on insulin receptors in obese mice.
The American journal of physiology 1988;255(2 Pt 1):E101-9.
1987: Jean-François Tanti; Thierry Grémeaux; N Rochet; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Effect of cyclic AMP-dependent protein kinase on insulin receptor tyrosine kinase activity.
The Biochemical journal 1987;245(1):19-26.
1987: Thierry Grémeaux; Jean-François Tanti; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Polymyxin B selectively inhibits insulin effects on transport in isolated muscle.
The American journal of physiology 1987;252(2 Pt 1):E248-54.
1986: Jean-François Tanti; Thierry Grémeaux; D Brandenburg; Emmanuel Van Obberghen; Yannick Le Marchand-Brustel
Brown adipose tissue in lean and obese mice. Insulin-receptor binding and tyrosine kinase activity.
Diabetes 1986;35(11):1243-8.
1985: Yannick Le Marchand-Brustel; Thierry Grémeaux; Robert Ballotti; Emmanuel Van Obberghen
Insulin receptor tyrosine kinase is defective in skeletal muscle of insulin-resistant obese mice.
Nature 1985;315(6021):676-9.