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Axel Gressner

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Olav Gressner; Hui Li; Lun-Gen Lu; Meng Fang; Axel M Gressner; Chun Fang Gao
Connective tissue growth factor (CTGF/CCN2) in serum is an indicator of fibrogenic progression and malignant transformation in patients with chronic hepatitis B infection.
Olav Gressner; Ieva Peredniene; Axel M Gressner
Connective tissue growth factor reacts as an IL-6/STAT3-regulated hepatic negative acute phase protein.
Joachim Kuhn; Olav Gressner; Christian Götting; Axel M Gressner; Knut Kleesiek
Increased serum xylosyltransferase activity in patients with liver fibrosis.

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2013: Olav Gressner; Hui Li; Lun-Gen Lu; Meng Fang; Axel M Gressner; Chun Fang Gao
Connective tissue growth factor (CTGF/CCN2) in serum is an indicator of fibrogenic progression and malignant transformation in patients with chronic hepatitis B infection.
Clinica chimica acta; international journal of clinical chemistry 2013;421():126-31.
2011: Olav Gressner; Ieva Peredniene; Axel M Gressner
Connective tissue growth factor reacts as an IL-6/STAT3-regulated hepatic negative acute phase protein.
World journal of gastroenterology : WJG 2011;17(2):151-63.
2009: Joachim Kuhn; Olav Gressner; Christian Götting; Axel M Gressner; Knut Kleesiek
Increased serum xylosyltransferase activity in patients with liver fibrosis.
Clinica chimica acta; international journal of clinical chemistry 2009;409(1-2):123-6.
2009: Olav Gressner; Nina Beer; Arkadius Jodlowski; Axel M Gressner
Impact of quality control accepted inter-laboratory variations on calculated Fibrotest/Actitest scores for the non-invasive biochemical assessment of liver fibrosis.
Clinica chimica acta; international journal of clinical chemistry 2009;409(1-2):90-5.
2009: Olav Gressner; Chunfang Gao; Monika Siluschek; Philipp Kim; Axel M Gressner
Inverse association between serum concentrations of actin-free vitamin D-binding protein and the histopathological extent of fibrogenic liver disease or hepatocellular carcinoma.
European journal of gastroenterology & hepatology 2009;21(9):990-5.
2009: E Kovalenko; Frank Tacke; Olav Gressner; H W Zimmermann; Birgit Lahme; A Janetzko; Tonio Wiederholt; T Berg; T Müller; Christian Trautwein; Axel M Gressner; Ralf Weiskirchen
Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis.
Journal of viral hepatitis 2009;16(9):612-20.
2009: Olav Gressner; Birgit Lahme; Monika Siluschek; Axel M Gressner
Identification of paraxanthine as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver parenchymal cells.
Liver international : official journal of the International Association for the Study of the Liver 2009;29(6):886-97.
2009: Olav Gressner; Birgit Lahme; Monika Siluschek; Katharina Rehbein; Ralf Weiskirchen; Axel M Gressner
Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor beta actions in hepatocytes--but without modulating bone morphogenetic protein 7 signaling.
Hepatology (Baltimore, Md.) 2009;49(6):2021-30.
2009: Axel M Gressner; Chun-Fang Gao; Olav Gressner
Non-invasive biomarkers for monitoring the fibrogenic process in liver: a short survey.
World journal of gastroenterology : WJG 2009;15(20):2433-40.
2009: Olav Gressner; Monika Siluschek; Birgit Lahme; Axel M Gressner
Intraperitoneal application of caffeine prevents D-galactosamine-induced hepatic expression of connective tissue growth factor (CTGF/CCN2) in the rat.
Journal of hepatology 2009;50(5):1053-5.
2009: Marianne Antoine; Roman Köhl; Carmen G Tag; Axel M Gressner; Claus Hellerbrand; Paul Kiefer
Secreted cysteine-rich FGF receptor derives from posttranslational processing by furin-like prohormone convertases.
Biochemical and biophysical research communications 2009;382(2):359-64.
2009: Olav Gressner; Shadi Jafari; M Erkens; Chunfang Gao; Sven Stanzel; Axel M Gressner
Evaluation of serum percent trisialotransferrin as potential predictive biomarker of hepatocellular dedifferentiation in chronic liver disease.
Clinica chimica acta; international journal of clinical chemistry 2009;403(1-2):188-93.
2009: Olav Gressner; Chunfang Gao; Katharina Rehbein; Birgit Lahme; Monika Siluschek; Thomas Berg; Tobias Müller; Axel M Gressner
Elevated concentrations of 15-deoxy-Delta12,14-prostaglandin J2 in chronic liver disease propose therapeutic trials with peroxisome proliferator activated receptor gamma-inducing drugs.
Liver international : official journal of the International Association for the Study of the Liver 2009;29(5):730-5.
2009: Martin Roderfeld; Ralf Weiskirchen; Srebrena Atanasova; Axel M Gressner; Klaus T Preissner; Elke Roeb; Sandip M Kanse
Altered factor VII activating protease expression in murine hepatic fibrosis and its influence on hepatic stellate cells.
Liver international : official journal of the International Association for the Study of the Liver 2009;29(5):686-91.
2009: Marianne Antoine; Carmen G Tag; Axel M Gressner; Claus Hellerbrand; Paul Kiefer
Expression of E-selectin ligand-1 (CFR/ESL-1) on hepatic stellate cells: implications for leukocyte extravasation and liver metastasis.
Oncology reports 2009;21(2):357-62.
2009: Olav Gressner; Marie-Claire Schifflers; Philipp Kim; Leo Heuts; Birgit Lahme; Axel M Gressner
Questioning the role of actinfree Gc-Globulin as actin scavenger in neurodegenerative central nervous system disease: relationship to S-100B levels and blood-brain barrier function.
Clinica chimica acta; international journal of clinical chemistry 2009;400(1-2):86-90.
2009: Ralf Weiskirchen; Steffen K Meurer; Olav Gressner; Jens Herrmann; Erawan Borkham-Kamphorst; Axel M Gressner
BMP-7 as antagonist of organ fibrosis.
Frontiers in bioscience : a journal and virtual library 2009;14():4992-5012.
2008: Olav Gressner; Birgit Lahme; Monika Siluschek; Katharina Rehbein; Jens Herrmann; Ralf Weiskirchen; Axel M Gressner
Activation of TGF-beta within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor.
Journal of cellular and molecular medicine 2008;12(6B):2717-30.
2008: Olav Gressner; Birgit Lahme; Katharina Rehbein; Monika Siluschek; Ralf Weiskirchen; Axel M Gressner
Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways.
Journal of hepatology 2008;49(5):758-67.
2008: Olav Gressner; Birgit Lahme; Monika Siluschek; Katharina Rehbein; Ralf Weiskirchen; Axel M Gressner
Intracrine signalling of activin A in hepatocytes upregulates connective tissue growth factor (CTGF/CCN2) expression.
Liver international : official journal of the International Association for the Study of the Liver 2008;28(9):1207-16.
2008: Erawan Borkham-Kamphorst; Evgenia Kovalenko; Claudia van Roeyen; Nikolaus Gassler; Michael Bomble; Tammo Ostendorf; Jürgen Floege; Axel M Gressner; Ralf Weiskirchen
Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injury.
Laboratory investigation; a journal of technical methods and pathology 2008;88(10):1090-100.
2008: Olav Gressner; Axel M Gressner
Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases.
Liver international : official journal of the International Association for the Study of the Liver 2008;28(8):1065-79.
2008: Werner Wirz; Marianne Antoine; Carmen G Tag; Axel M Gressner; T Korff; C Hellerbrand; Paul Kiefer
Hepatic stellate cells display a functional vascular smooth muscle cell phenotype in a three-dimensional co-culture model with endothelial cells.
Differentiation; research in biological diversity 2008;76(7):784-94.
2008: Hao Wang; Yun-Peng Zhao; Chun-Fang Gao; Qiang Ji; Axel M Gressner; Zai-Xing Yang; Ralf Weiskirchen
Transforming growth factor beta 1 gene variants increase transcription and are associated with liver cirrhosis in Chinese.
Cytokine 2008;43(1):20-5.
2008: Olav A Gressner; Mohamed S Rizk; Evgeniya Kovalenko; Ralf Weiskirchen; Axel M Gressner
Changing the pathogenetic roadmap of liver fibrosis? Where did it start; where will it go?
Journal of gastroenterology and hepatology 2008;23(7 Pt 1):1024-35.
2008: Carmen G Tag; Christian Oberkanins; Gernot Kriegshäuser; Catherine J E Ingram; Dallas M Swallow; Axel M Gressner; Maximilian Ledochowski; Ralf Weiskirchen
Evaluation of a novel reverse-hybridization StripAssay for typing DNA variants useful in diagnosis of adult-type hypolactasia.
Clinica chimica acta; international journal of clinical chemistry 2008;392(1-2):58-62.
2008: Olav Gressner; Birgit Lahme; Axel M Gressner
Gc-globulin (vitamin D binding protein) is synthesized and secreted by hepatocytes and internalized by hepatic stellate cells through Ca(2+)-dependent interaction with the megalin/gp330 receptor.
Clinica chimica acta; international journal of clinical chemistry 2008;390(1-2):28-37.
2008: Chun-Fang Gao; Axel M Gressner; Cuiying Chen
[Potential novel biomarkers for monitoring the fibrogenic process in livers].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 2008;16(3):173-4.
2008: Laura Kahmann; Peter Uciechowski; Sabine Warmuth; Birgit Plümäkers; Axel M Gressner; Marco Malavolta; Eugenio Mocchegiani; Lothar Rink
Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions.
Rejuvenation research 2008;11(1):227-37.
2008: Olav Gressner; Birgit Lahme; Martin Koch; Axel M Gressner
Evaluation of hepatotropic targeting properties of allogenic and xenogenic erythrocyte ghosts in normal and liver-injured rats.
Liver international : official journal of the International Association for the Study of the Liver 2008;28(2):220-32.
2008: Sabine Muetze; Brigitte Leeners; Jan R Ortlepp; Sabine Kuse; Carmen G Tag; Ralf Weiskirchen; Axel M Gressner; Sabine Rudnik-Schoeneborn; Klaus Zerres; Werner Rath
Maternal factor V Leiden mutation is associated with HELLP syndrome in Caucasian women.
Acta obstetricia et gynecologica Scandinavica 2008;87(6):635-42.
2008: Falko Drews; Sebastian Knöbel; Markus Moser; Kai G Muhlack; Simone Mohren; Christian Stoll; Andreas Bosio; Axel M Gressner; Ralf Weiskirchen
Disruption of the latent transforming growth factor-beta binding protein-1 gene causes alteration in facial structure and influences TGF-beta bioavailability.
Biochimica et biophysica acta 2008;1783(1):34-48.
2007: Jens Herrmann; Ute Haas; Axel M Gressner; Ralf Weiskirchen
TGF-beta up-regulates serum response factor in activated hepatic stellate cells.
Biochimica et biophysica acta 2007;1772(11-12):1250-7.
2007: J J W Tischendorf; Eray Yagmur; D Scholten; D Vidacek; A Koch; Ron Winograd; Axel M Gressner; Christian Trautwein; Hermann E Wasmuth; Frank Lammert
The interleukin-6 (IL6)-174 G/C promoter genotype is associated with the presence of septic shock and the ex vivo secretion of IL6.
International journal of immunogenetics 2007;34(6):413-8.
2007: Olav Gressner; Birgit Lahme; Ilhan Demirci; Axel M Gressner; Ralf Weiskirchen
Differential effects of TGF-beta on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes.
Journal of hepatology 2007;47(5):699-710.
2007: Marianne Antoine; Werner Wirz; Carmen G Tag; Axel M Gressner; Meltem Marvituna; Mathias Wycislo; Claus Hellerbrand; Paul Kiefer
Expression and function of fibroblast growth factor (FGF) 9 in hepatic stellate cells and its role in toxic liver injury.
Biochemical and biophysical research communications 2007;361(2):335-41.
2007: Olav Gressner; Ralf Weiskirchen; Axel M Gressner
Biomarkers of hepatic fibrosis, fibrogenesis and genetic pre-disposition pending between fiction and reality.
Journal of cellular and molecular medicine 2007;11(5):1031-51.
2007: Eray Yagmur; Mohamed Rizk; Sven Stanzel; Claus Hellerbrand; Frank Lammert; Christian Trautwein; Hermann E Wasmuth; Axel M Gressner
Elevation of endoglin (CD105) concentrations in serum of patients with liver cirrhosis and carcinoma.
European journal of gastroenterology & hepatology 2007;19(9):755-61.
2007: Felix Gramley; Johann Lorenzen; Jurgita Plisiene; Mindaugas Rakauskas; Rimantas Benetis; Michael Schmid; Rüdiger Autschbach; Christian Knackstedt; Thomas Schimpf; Karl Mischke; Axel M Gressner; Peter Hanrath; Malte Kelm; Patrick Schauerte
Decreased plasminogen activator inhibitor and tissue metalloproteinase inhibitor expression may promote increased metalloproteinase activity with increasing duration of human atrial fibrillation.
Journal of cardiovascular electrophysiology 2007;18(10):1076-82.
2007: Ralf Weiskirchen; Carmen G Tag; Senait Mengsteab; Axel M Gressner; Catherine J E Ingram; Dallas M Swallow
Pitfalls in LightCycler diagnosis of the single-nucleotide polymorphism 13.9 kb upstream of the lactase gene that is associated with adult-type hypolactasia.
Clinica chimica acta; international journal of clinical chemistry 2007;384(1-2):93-8.
2007: Jens Herrmann; Axel M Gressner; Ralf Weiskirchen
Immortal hepatic stellate cell lines: useful tools to study hepatic stellate cell biology and function?
Journal of cellular and molecular medicine 2007;11(4):704-22.
2007: Eva Poll; Ilonka Kreitschmann-Andermahr; Yvonne Langejuergen; Sven Stanzel; Joachim M Gilsbach; Axel M Gressner; Eray Yagmur
Saliva collection method affects predictability of serum cortisol.
Clinica chimica acta; international journal of clinical chemistry 2007;382(1-2):15-9.
2007: Olav Gressner; Ralf Weiskirchen; Axel M Gressner
Biomarkers of liver fibrosis: clinical translation of molecular pathogenesis or based on liver-dependent malfunction tests.
Clinica chimica acta; international journal of clinical chemistry 2007;381(2):107-13.
2007: Erawan Borkham-Kamphorst; Claudia van Roeyen; Tammo Ostendorf; Jürgen Floege; Axel M Gressner; Ralf Weiskirchen
Pro-fibrogenic potential of PDGF-D in liver fibrosis.
Journal of hepatology 2007;46(6):1064-74.
2007: Eray Yagmur; Christian Trautwein; Mathie Leers; Axel M Gressner; Frank Tacke
Elevated apoptosis-associated cytokeratin 18 fragments (CK18Asp386) in serum of patients with chronic liver diseases indicate hepatic and biliary inflammation.
Clinical biochemistry 2007;40(9-10):651-5.
2007: Olaf Scherner; Steffen K Meurer; Lidia Tihaa; Axel M Gressner; Ralf Weiskirchen
Endoglin differentially modulates antagonistic transforming growth factor-beta1 and BMP-7 signaling.
The Journal of biological chemistry 2007;282(19):13934-43.
2007: Eray Yagmur; Ralf Weiskirchen; Axel M Gressner; Christian Trautwein; Frank Tacke
Insulin resistance in liver cirrhosis is not associated with circulating retinol-binding protein 4.
Diabetes care 2007;30(5):1168-72.
2007: Torsten Arndt; Manfred Erkens; Kristian Holtkamp; Thomas Keller; Axel M Gressner
High prevalence of increased trisialotransferrin concentrations in patients with anorexia nervosa: implications for determination of carbohydrate-deficient transferrin.
Clinica chimica acta; international journal of clinical chemistry 2007;379(1-2):150-3.
2007: Oliver Purps; Birgit Lahme; Axel M Gressner; Nadja M Meindl-Beinker; Steven Dooley
Loss of TGF-beta dependent growth control during HSC transdifferentiation.
Biochemical and biophysical research communications 2007;353(3):841-7.
2007: Honglei Weng; Peter R Mertens; Axel M Gressner; Steven Dooley
IFN-gamma abrogates profibrogenic TGF-beta signaling in liver by targeting expression of inhibitory and receptor Smads.
Journal of hepatology 2007;46(2):295-303.
2007: Olav Gressner; Ralf Weiskirchen; Axel M Gressner
Evolving concepts of liver fibrogenesis provide new diagnostic and therapeutic options.
Comparative hepatology 2007;6():7.
2007: Lucia Wickert; Nicolas Chatain; Karin Kruschinsky; Axel M Gressner
Glucocorticoids activate TGF-beta induced PAI-1 and CTGF expression in rat hepatocytes.
Comparative hepatology 2007;6():5.
2007: Florian Winau; Guido Hegasy; Ralf Weiskirchen; Stephan Weber; Cécile Cassan; Peter Allan Sieling; Robert L Modlin; Roland S Liblau; Axel M Gressner; Stefan H E Kaufmann
Ito cells are liver-resident antigen-presenting cells for activating T cell responses.
Immunity 2007;26(1):117-29.
2007: Carmen G Tag; Marie-Claire Schifflers; Monika Mohnen; Axel M Gressner; Ralf Weiskirchen
A novel proximal -13914G>A base replacement in the vicinity of the common-13910T/C lactase gene variation results in an atypical LightCycler melting curve in testing with the MutaREAL Lactase test.
Clinical chemistry 2007;53(1):146-8.
2006: Torsten Arndt; Axel M Gressner; Jürgen Herwig; Ursula Meier; Adrian C Sewell
Argininosuccinate lyase deficiency (ASL) and carbohydrate-deficient transferrin (CDT): experience with four independent CDT analysis methods--misleading results given by the %CDT TIA assay.
Clinica chimica acta; international journal of clinical chemistry 2006;373(1-2):117-20.
2006: Harun Seyhan; Jafar Hamzavi; Eliza Wiercinska; Axel M Gressner; Peter R Mertens; Jürgen Kopp; Raymund E Horch; Katja Breitkopf; Steven Dooley
Liver fibrogenesis due to cholestasis is associated with increased Smad7 expression and Smad3 signaling.
Journal of cellular and molecular medicine 2006;10(4):922-32.
2006: Torsten Arndt; Ursula Meier; Markus Nauck; Axel M Gressner
Primary biliary cirrhosis is not a clinical condition for increased carbohydrate-deficient transferrin: experience with four independent CDT analysis methods.
Clinica chimica acta; international journal of clinical chemistry 2006;372(1-2):184-7.
2006: Eray Yagmur; B Schnyder; D Scholten; Ramin Schirin-Sokhan; A Koch; Ron Winograd; Axel M Gressner; Christian Trautwein; Hermann E Wasmuth
[Elevated concentrations of fecal calprotectin in patients with liver cirrhosis].
Deutsche medizinische Wochenschrift (1946) 2006;131(36):1930-4.
2006: Axel M Gressner; Eray Yagmur; Birgit Lahme; Olav Gressner; Sven Stanzel
Connective tissue growth factor in serum as a new candidate test for assessment of hepatic fibrosis.
Clinical chemistry 2006;52(9):1815-7.
2006: Juliane K Unger; Claudia Haltern; Britta Portz; Bernhard M Dohmen; Axel M Gressner; Rolf Rossaint
Relation of haemofilter type to venous catheter resistance is crucial for filtration performance and haemocompatibility in CVVH--an in vitro study.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2006;21(8):2191-201.
2006: Marianne Antoine; Werner Wirz; Carmen G Tag; Axel M Gressner; M Wycislo; Robert Müller; Paul Kiefer
Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation.
Biochemical and biophysical research communications 2006;346(1):224-33.
2006: Jens Herrmann; Erawan Borkham-Kamphorst; Ute Haas; Eddy Van de Leur; Mario F Fraga; Manel Esteller; Axel M Gressner; Ralf Weiskirchen
The expression of CSRP2 encoding the LIM domain protein CRP2 is mediated by TGF-beta in smooth muscle and hepatic stellate cells.
Biochemical and biophysical research communications 2006;345(4):1526-35.
2006: Ursula Meier; Olav Gressner; Frank Lammert; Axel M Gressner
Gc-globulin: roles in response to injury.
Clinical chemistry 2006;52(7):1247-53.
2006: Eray Yagmur; Christian Trautwein; Axel M Gressner; Frank Tacke
Resistin serum levels are associated with insulin resistance, disease severity, clinical complications, and prognosis in patients with chronic liver diseases.
The American journal of gastroenterology 2006;101(6):1244-52.
2006: Eliza Wiercinska; Lucia Wickert; Bernd Denecke; Harun M Said; Jafar Hamzavi; Axel M Gressner; Midori Thorikay; Peter ten Dijke; Peter R Mertens; Katja Breitkopf; Steven Dooley
Id1 is a critical mediator in TGF-beta-induced transdifferentiation of rat hepatic stellate cells.
Hepatology (Baltimore, Md.) 2006;43(5):1032-41.
2006: Svenja Neyzen; Eddy Van de Leur; Erawan Borkham-Kamphorst; Jens Herrmann; Günter Hollweg; Axel M Gressner; Ralf Weiskirchen
Cryopreservation of hepatic stellate cells.
Journal of hepatology 2006;44(5):910-7.
2006: Martin Roderfeld; Ralf Weiskirchen; Sandra Wagner; Marie-Luise Berres; Corinna Henkel; Joachim Grötzinger; Axel M Gressner; Siegfried Matern; Elke Roeb
Inhibition of hepatic fibrogenesis by matrix metalloproteinase-9 mutants in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(3):444-54.
2006: Axel M Gressner; Birgit Lahme; Steffen K Meurer; Olav Gressner; Ralf Weiskirchen
Variable expression of cystatin C in cultured trans-differentiating rat hepatic stellate cells.
World journal of gastroenterology : WJG 2006;12(5):731-8.
2006: Steven Dooley; Harun M Said; Axel M Gressner; Jürgen Floege; Abdelaziz En-Nia; Peter R Mertens
Y-box protein-1 is the crucial mediator of antifibrotic interferon-gamma effects.
The Journal of biological chemistry 2006;281(3):1784-95.
2006: Eray Yagmur; Reinhard Driesch; Axel M Gressner; Paul Kiefer
Technical evaluation of the Beckman Coulter OV-Monitor (CA 125 antigen) immunoassay.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2006;44(4):420-2.
2006: Jürgen Kopp; Harun Seyhan; Bastian Müller; Johanna Lanczak; Elke Pausch; Axel M Gressner; Steven Dooley; Raymund E Horch
N-acetyl-L-cysteine abrogates fibrogenic properties of fibroblasts isolated from Dupuytren's disease by blunting TGF-beta signalling.
Journal of cellular and molecular medicine 2006;10(1):157-65.
2006: Axel M Gressner; Ralf Weiskirchen
Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets.
Journal of cellular and molecular medicine 2006;10(1):76-99.
2006: Eray Yagmur; Frank Tacke; Claudia Weiss; Birgit Lahme; Michael P Manns; Paul Kiefer; Christian Trautwein; Axel M Gressner
Elevation of Nepsilon-(carboxymethyl)lysine-modified advanced glycation end products in chronic liver disease is an indicator of liver cirrhosis.
Clinical biochemistry 2006;39(1):39-45.
2006: Obul Reddy Bandapalli; Martina Geheeb; Dennis Kobelt; katrin kuehnle; Sefer Elezkurtaj; Jens Herrmann; Axel M Gressner; Ralf Weiskirchen; Dieter Beule; Nils Blüthgen; Hanspeter Herzel; Claudia Franke; Karsten Brand
Global analysis of host tissue gene expression in the invasive front of colorectal liver metastases.
International journal of cancer. Journal international du cancer 2006;118(1):74-89.
2005: Erawan Borkham-Kamphorst; Steffen K Meurer; Axel M Gressner; Ralf Weiskirchen
Disruption of intermolecular disulfide bonds in PDGF-BB dimers by N-acetyl-L-cysteine does not prevent PDGF signaling in cultured hepatic stellate cells.
Biochemical and biophysical research communications 2005;338(4):1711-8.
2005: Marianne Antoine; Kerstin Reimers; Werner Wirz; Axel M Gressner; Robert Müller; Paul Kiefer
Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2.
Biochemical and biophysical research communications 2005;338(2):1248-55.
2005: Marianne Antoine; Carmen G Tag; Werner Wirz; Erawan Borkham-Kamphorst; Iris Sawitza; Axel M Gressner; Paul Kiefer
Upregulation of pleiotrophin expression in rat hepatic stellate cells by PDGF and hypoxia: implications for its role in experimental biliary liver fibrogenesis.
Biochemical and biophysical research communications 2005;337(4):1153-64.
2005: Steffen K Meurer; Birgit Lahme; Lidia Tihaa; Ralf Weiskirchen; Axel M Gressner
N-acetyl-L-cysteine suppresses TGF-beta signaling at distinct molecular steps: the biochemical and biological efficacy of a multifunctional, antifibrotic drug.
Biochemical pharmacology 2005;70(7):1026-34.
2005: Marianne Antoine; Kerstin Reimers; Werner Wirz; Axel M Gressner; Robert Müller; Paul Kiefer
Identification of an unconventional nuclear localization signal in human ribosomal protein S2.
Biochemical and biophysical research communications 2005;335(1):146-53.
2005: Katja Breitkopf; Claudia van Roeyen; Iris Sawitza; Lucia Wickert; Jürgen Floege; Axel M Gressner
Expression patterns of PDGF-A, -B, -C and -D and the PDGF-receptors alpha and beta in activated rat hepatic stellate cells (HSC).
Cytokine 2005;31(5):349-57.
2005: Juliane K Unger; Claudia Haltern; Bernhard M Dohmen; Axel M Gressner; Christian Grosse-Siestrup; David A Groneberg; Rolf Rossaint
Albumin and hydroxyethyl starch 130 kDa/0.4 improve filter clearance and haemocompatibility in haemo- and plasmafiltration--an in vitro study.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2005;20(9):1922-31.
2005: Carmen G Tag; Marie-Claire Schifflers; Monika Mohnen; Axel M Gressner; Ralf Weiskirchen
Atypical melting curve resulting from genetic variation in the 3' untranslated region at position 20218 in the prothrombin gene analyzed with the LightCycler factor II (prothrombin) G20210A assay.
Clinical chemistry 2005;51(8):1560-1.
2005: Sonja Hillebrandt; Hermann E Wasmuth; Ralf Weiskirchen; Claus Hellerbrand; Hildegard Keppeler; Alexa Werth; Ramin Schirin-Sokhan; Gabriele Wilkens; Andreas Geier; Johann Lorenzen; Jörg Köhl; Axel M Gressner; Siegfried Matern; Frank Lammert
Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans.
Nature genetics 2005;37(8):835-43.
2005: Jürgen Kopp; Ellen Preis; Harun Said; Bernd Hafemann; Lucia Wickert; Axel M Gressner; Norbert Pallua; Steven Dooley
Abrogation of transforming growth factor-beta signaling by SMAD7 inhibits collagen gel contraction of human dermal fibroblasts.
The Journal of biological chemistry 2005;280(22):21570-6.
2005: Marianne Antoine; Werner Wirz; Carmen G Tag; M Mavituna; Neil Emans; T Korff; V Stoldt; Axel M Gressner; Paul Kiefer
Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells.
Growth factors (Chur, Switzerland) 2005;23(2):87-95.
2005: Katja Breitkopf; Iris Sawitza; Axel M Gressner
Characterization of intracellular pathways leading to coinduction of thrombospondin-1 and TGF-beta1 expression in rat hepatic stellate cells.
Growth factors (Chur, Switzerland) 2005;23(2):77-85.
2005: Susanne Lindert; Lucia Wickert; Iris Sawitza; Eliza Wiercinska; Axel M Gressner; Steven Dooley; Katja Breitkopf
Transdifferentiation-dependent expression of alpha-SMA in hepatic stellate cells does not involve TGF-beta pathways leading to coinduction of collagen type I and thrombospondin-2.
Matrix biology : journal of the International Society for Matrix Biology 2005;24(3):198-207.
2005: Katja Breitkopf; Iris Sawitza; J H Westhoff; Lucia Wickert; Steven Dooley; Axel M Gressner
Thrombospondin 1 acts as a strong promoter of transforming growth factor beta effects via two distinct mechanisms in hepatic stellate cells.
Gut 2005;54(5):673-81.
2005: Hao Wang; Senait Mengsteab; Carmen G Tag; Chun-Fang Gao; Claus Hellerbrand; Frank Lammert; Axel M Gressner; Ralf Weiskirchen
Transforming growth factor-beta1 gene polymorphisms are associated with progression of liver fibrosis in Caucasians with chronic hepatitis C infection.
World journal of gastroenterology : WJG 2005;11(13):1929-36.
2005: Hermann E Wasmuth; Dagmar Kunz; Eray Yagmur; Annette Timmer-Stranghöner; Daniel Vidacek; Elmar Siewert; Jens Bach; Andreas Geier; Edmund A Purucker; Axel M Gressner; Siegfried Matern; Frank Lammert
Patients with acute on chronic liver failure display "sepsis-like" immune paralysis.
Journal of hepatology 2005;42(2):195-201.
2005: Steffen K Meurer; Lidia Tihaa; Birgit Lahme; Axel M Gressner; Ralf Weiskirchen
Identification of endoglin in rat hepatic stellate cells: new insights into transforming growth factor beta receptor signaling.
The Journal of biological chemistry 2005;280(4):3078-87.
2005: Ralf Weiskirchen; Axel M Gressner
Isolation and culture of hepatic stellate cells.
Methods in molecular medicine 2005;117():99-113.
2004: Ursula Bolkenius; Daniela Hahn; Axel M Gressner; Katja Breitkopf; Steven Dooley; Lucia Wickert
Glucocorticoids decrease the bioavailability of TGF-beta which leads to a reduced TGF-beta signaling in hepatic stellate cells.
Biochemical and biophysical research communications 2004;325(4):1264-70.
2004: Ilonka Kreitschmann-Andermahr; Christine Hoff; Bernhard Saller; Sandra Niggemeier; Sabine Pruemper; Bernd O Hütter; Veit Rohde; Axel M Gressner; Siegfried Matern; Joachim M Gilsbach
Prevalence of pituitary deficiency in patients after aneurysmal subarachnoid hemorrhage.
The Journal of clinical endocrinology and metabolism 2004;89(10):4986-92.
2004: Ursula Meier; Axel M Gressner
Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin.
Clinical chemistry 2004;50(9):1511-25.
2004: Erawan Borkham-Kamphorst; Doris Stoll; Axel M Gressner; Ralf Weiskirchen
Antisense strategy against PDGF B-chain proves effective in preventing experimental liver fibrogenesis.
Biochemical and biophysical research communications 2004;321(2):413-23.
2004: Jens Herrmann; B Abriss; Eddy Van de Leur; Sabine Weiskirchen; Axel M Gressner; Ralf Weiskirchen
Comparative analysis of adenoviral transgene delivery via tail or portal vein into rat liver.
Archives of virology 2004;149(8):1611-7.
2004: Andreas Geier; Michael Reugels; Ralf Weiskirchen; Hermann E Wasmuth; Christoph G Dietrich; Elmar Siewert; Carsten Gartung; Johann Lorenzen; Anja Bosserhoff; Marc Brügmann; Axel M Gressner; Siegfried Matern; Frank Lammert
Common heterozygous hemochromatosis gene mutations are risk factors for inflammation and fibrosis in chronic hepatitis C.
Liver international : official journal of the International Association for the Study of the Liver 2004;24(4):285-94.
2004: Christian Stoll; Senait Mengsteab; Doris Stoll; Dieter Riediger; Axel M Gressner; Ralf Weiskirchen
Analysis of polymorphic TGFB1 codons 10, 25, and 263 in a German patient group with non-syndromic cleft lip, alveolus, and palate compared with healthy adults.
BMC medical genetics 2004;5():15.
2004: Erawan Borkham-Kamphorst; Jens Herrmann; Doris Stoll; Jens Treptau; Axel M Gressner; Ralf Weiskirchen
Dominant-negative soluble PDGF-beta receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis.
Laboratory investigation; a journal of technical methods and pathology 2004;84(6):766-77.
2004: Hermann E Wasmuth; Dagmar Kunz; Jürgen Graf; Sven Stanzel; Edmund A Purucker; Alexander Koch; Carsten Gartung; Bernhard Heintz; Axel M Gressner; Siegfried Matern; Frank Lammert
Hyperglycemia at admission to the intensive care unit is associated with elevated serum concentrations of interleukin-6 and reduced ex vivo secretion of tumor necrosis factor-alpha.
Critical care medicine 2004;32(5):1109-14.
2004: Erawan Borkham-Kamphorst; Doris Stoll; Axel M Gressner; Ralf Weiskirchen
Inhibitory effect of soluble PDGF-beta receptor in culture-activated hepatic stellate cells.
Biochemical and biophysical research communications 2004;317(2):451-62.
2004: Nora Janoschek; Eddy Van de Leur; Axel M Gressner; Ralf Weiskirchen
Induction of cell death in activated hepatic stellate cells by targeted gene expression of the thymidine kinase/ganciclovir system.
Biochemical and biophysical research communications 2004;316(4):1107-15.
2004: Ursula Meier; Claudia Schnabel; Dagmar Kunz; Reinhard Driesch; Axel M Gressner
Comparison of three commercial assays for the measurement of 17alpha-hydroxyprogesterone (17alpha-OHPR): limitations of the quality control system.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2004;42(4):450-4.
2004: Claudia Schnabel; Ercole Di Martino; Joachim M Gilsbach; Dieter Riediger; Axel M Gressner; Dagmar Kunz
Comparison of beta2-transferrin and beta-trace protein for detection of cerebrospinal fluid in nasal and ear fluids.
Clinical chemistry 2004;50(3):661-3.
2004: Jens Herrmann; Monica Arias; Eddy Van de Leur; Axel M Gressner; Ralf Weiskirchen
CSRP2, TIMP-1, and SM22alpha promoter fragments direct hepatic stellate cell-specific transgene expression in vitro, but not in vivo.
Liver international : official journal of the International Association for the Study of the Liver 2004;24(1):69-79.
2004: Lucia Wickert; Muna Abiaka; Ursula Bolkenius; Axel M Gressner
Corticosteroids stimulate selectively transforming growth factor (TGF)-beta receptor type III expression in transdifferentiating hepatic stellate cells.
Journal of hepatology 2004;40(1):69-76.
2003: Carmen G Tag; Senait Mengsteab; Claus Hellerbrand; Frank Lammert; Axel M Gressner; Ralf Weiskirchen
Analysis of the transforming growth factor-beta1 (TGF-beta1) codon 25 gene polymorphism by LightCycler-analysis in patients with chronic hepatitis C infection.
Cytokine 2003;24(5):173-81.
2003: Thomas Körner; Jürgen Kropf; Britta Kosche; Hartmut Kristahl; Daniel Jaspersen; Axel M Gressner
Improvement of prognostic power of the Child-Pugh classification of liver cirrhosis by hyaluronan.
Journal of hepatology 2003;39(6):947-53.
2003: Axel M Gressner; Ralf Weiskirchen
The tightrope of therapeutic suppression of active transforming growth factor-beta: high enough to fall deeply?
Journal of hepatology 2003;39(5):856-9.
2003: Monica Arias; Sibille Sauer-Lehnen; Jens Treptau; Nora Janoschek; Ingo Theuerkauf; Reinhard Buettner; Axel M Gressner; Ralf Weiskirchen
Adenoviral expression of a transforming growth factor-beta1 antisense mRNA is effective in preventing liver fibrosis in bile-duct ligated rats.
BMC gastroenterology 2003;3():29.
2003: Michael Fries; Dagmar Kunz; Axel M Gressner; Rolf Rossaint; Ralf Kuhlen
Procalcitonin serum levels after out-of-hospital cardiac arrest.
Resuscitation 2003;59(1):105-9.
2003: Jens H Westhoff; Iris Sawitza; Jorma Keski-Oja; Axel M Gressner; Katja Breitkopf
PDGF-BB induces expression of LTBP-1 but not TGF-beta1 in a rat cirrhotic fat storing cell line.
Growth factors (Chur, Switzerland) 2003;21(3-4):121-30.
2003: Steven Dooley; Jafar Hamzavi; Katja Breitkopf; Eliza Wiercinska; Harun M Said; Johann Lorenzen; Peter ten Dijke; Axel M Gressner
Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats.
Gastroenterology 2003;125(1):178-91.
2003: Ralf Weiskirchen; Markus Moser; Kalle Günther; Sabine Weiskirchen; Axel M Gressner
The murine latent transforming growth factor-beta binding protein (Ltbp-1) is alternatively spliced, and maps to a region syntenic to human chromosome 2p21-22.
Gene 2003;308():43-52.
2003: Kalle Günther; Doris Stoll; Gerhard Jakse; Axel M Gressner; Ralf Weiskirchen
Rapid detection of CSRP2 mRNA in mouse, rat, and human using LightCycler-based quantitative real-time polymerase chain reaction.
Analytical biochemistry 2003;314(1):144-8.
2003: Bärbel Abriss; Günter Hollweg; Axel M Gressner; Ralf Weiskirchen
Adenoviral-mediated transfer of p53 or retinoblastoma protein blocks cell proliferation and induces apoptosis in culture-activated hepatic stellate cells.
Journal of hepatology 2003;38(2):169-78.
2002: Claudia Haltern; Juliane K Unger; Bernhard M Dohmen; Axel M Gressner; Rolf Rossaint
The influence of HES on the filtration properties of capillary membrane plasmaseparation.
The International journal of artificial organs 2002;25(8):798-805.
2002: Lucia Wickert; S Steinkrüger; M Abiaka; Ursula Bolkenius; O Purps; Claudia Schnabel; Axel M Gressner
Quantitative monitoring of the mRNA expression pattern of the TGF-beta-isoforms (beta 1, beta 2, beta 3) during transdifferentiation of hepatic stellate cells using a newly developed real-time SYBR Green PCR.
Biochemical and biophysical research communications 2002;295(2):330-5.
2002: Monica Arias; Birgit Lahme; Eddy Van de Leur; Axel M Gressner; Ralf Weiskirchen
Adenoviral delivery of an antisense RNA complementary to the 3' coding sequence of transforming growth factor-beta1 inhibits fibrogenic activities of hepatic stellate cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2002;13(6):265-73.
2002: Jiri Kanta; Steven Dooley; Bert Delvoux; Sebastian Breuer; Thomas D'Amico; Axel M Gressner
Tropoelastin expression is up-regulated during activation of hepatic stellate cells and in the livers of CCl(4)-cirrhotic rats.
Liver 2002;22(3):220-7.
2002: Axel M Gressner; Ralf Weiskirchen; Katja Breitkopf; Steven Dooley
Roles of TGF-beta in hepatic fibrosis.
Frontiers in bioscience : a journal and virtual library 2002;7():d793-807.
2002: Jan Gewaltig; Kerstin Mangasser-Stephan; Carsten Gartung; Stefan Biesterfeld; Axel M Gressner
Association of polymorphisms of the transforming growth factor-beta1 gene with the rate of progression of HCV-induced liver fibrosis.
Clinica chimica acta; international journal of clinical chemistry 2002;316(1-2):83-94.
2001: Juliane K Unger; V R Janssen; A Kashefi; Claudia Haltern; Bernd Klosterhalfen; Yvan Fischer; Axel M Gressner; Rolf Rossaint
Enhancing filtration rates by the use of blood flow around the capillaries of plasmafilters: an in vitro study.
The International journal of artificial organs 2001;24(11):821-31.
2001: Ralf Weiskirchen; Markus Moser; Sabine Weiskirchen; Martin Erdel; Stefan Dahmen; R Buettner; Axel M Gressner
LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1.
The Biochemical journal 2001;359(Pt 3):485-96.
2001: Carmen G Tag; Axel M Gressner; Ralf Weiskirchen
An unusual melting curve profile in LightCycler multiplex genotyping of the hemochromatosis H63D/C282Y gene mutations.
Clinical biochemistry 2001;34(6):511-5.
2001: Steven Dooley; Bert Delvoux; M Streckert; L Bonzel; M Stopa; Peter ten Dijke; Axel M Gressner
Transforming growth factor beta signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts. TGFbeta signal transduction during transdifferentiation of hepatic stellate cells.
FEBS letters 2001;502(1-2):4-10.
2001: Chun-Fang Gao; Xian-Tao Kong; Axel M Gressner; Ralf Weiskirchen
The expression and antigenicity identification of recombinant rat TGF-beta1 in bacteria.
Cell research 2001;11(2):95-100.
2001: Steven Dooley; M Streckert; Bert Delvoux; Axel M Gressner
Expression of Smads during in vitro transdifferentiation of hepatic stellate cells to myofibroblasts.
Biochemical and biophysical research communications 2001;283(3):554-62.
2001: Kerstin Mangasser-Stephan; Carsten Gartung; Birgit Lahme; Axel M Gressner
Expression of isoforms and splice variants of the latent transforming growth factor beta binding protein (LTBP) in cultured human liver myofibroblasts.
Liver 2001;21(2):105-13.
2001: Yvan Fischer; Karsten Filzmaier; HM Stiegler; Jürgen Graf; S Fuhs; A Franke; U Janssens; Axel M Gressner
Evaluation of a new, rapid bedside test for quantitative determination of B-type natriuretic peptide.
Clinical chemistry 2001;47(3):591-4.
2001: Katja Breitkopf; Birgit Lahme; Carmen G Tag; Axel M Gressner
Expression and matrix deposition of latent transforming growth factor beta binding proteins in normal and fibrotic rat liver and transdifferentiating hepatic stellate cells in culture.
Hepatology (Baltimore, Md.) 2001;33(2):387-96.
2000: M Stopa; Dirk Anhuf; L Terstegen; P Gatsios; Axel M Gressner; Steven Dooley
Participation of Smad2, Smad3, and Smad4 in transforming growth factor beta (TGF-beta)-induced activation of Smad7. THE TGF-beta response element of the promoter requires functional Smad binding element and E-box sequences for transcriptional regulation.
The Journal of biological chemistry 2000;275(38):29308-17.
2000: HM Stiegler; Yvan Fischer; Jaime F Vazquez-Jimenez; Jürgen Graf; Karsten Filzmaier; Bernd Fausten; U Janssens; Axel M Gressner; Dagmar Kunz
Lower cardiac troponin T and I results in heparin-plasma than in serum.
Clinical chemistry 2000;46(9):1338-44.
2000: Ralf Weiskirchen; Axel M Gressner
The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP).
Biochemical and biophysical research communications 2000;274(3):655-63.
2000: Steven Dooley; Bert Delvoux; Birgit Lahme; Kerstin Mangasser-Stephan; Axel M Gressner
Modulation of transforming growth factor beta response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts.
Hepatology (Baltimore, Md.) 2000;31(5):1094-106.
2000: M Stopa; V Benes; W Ansorge; Axel M Gressner; Steven Dooley
Genomic locus and promoter region of rat Smad7, an important antagonist of TGFbeta signaling.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(2):169-76.
2000: Ralf Weiskirchen; J Kneifel; Sabine Weiskirchen; Eddy Van de Leur; D Kunz; Axel M Gressner
Comparative evaluation of gene delivery devices in primary cultures of rat hepatic stellate cells and rat myofibroblasts.
BMC cell biology 2000;1():4.
1999: Kerstin Mangasser-Stephan; Carmen G Tag; A Reiser; Axel M Gressner
Rapid genotyping of hemochromatosis gene mutations on the LightCycler with fluorescent hybridization probes.
Clinical chemistry 1999;45(10):1875-8.
1999: Kerstin Mangasser-Stephan; Axel M Gressner
Molecular and functional aspects of latent transforming growth factor-beta binding protein: just a masking protein?
Cell and tissue research 1999;297(3):363-70.
1998: Axel M Gressner
The cell biology of liver fibrogenesis - an imbalance of proliferation, growth arrest and apoptosis of myofibroblasts.
Cell and tissue research 1998;292(3):447-52.