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Heidi Greulich

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Publications

TOP 3
Grit S Herter-Sprie; Heidi Greulich; Kwok-Kin Wong
Activating Mutations in ERBB2 and Their Impact on Diagnostics and Treatment.
Heidi Greulich; William C Hahn; Marcin Imielinski; Jacob D Jaffe; Bethany Kaplan; Michael S Lawrence; Se-Hoon Lee; Rachel Liao; D R Mani; Philipp Mertins; Lauren Ambrogio; Shantanu Banerji; Alice H Berger; Steven A Carr; Tzu-Hsiu Chen; Jeonghee Cho; Michael J Eck; David Frank; Gad Getz; Nam H Pho; Kumiko E Tanaka; Sarah R Walker; Wendy Winckler; Kwok-Kin Wong; Cai-Hong Yun; Jinghui Zhang; Xiaohong Zhang; Matthew Meyerson
Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.
Amit Dutt; Nathanael S Gray; Heidi Greulich; Peter S Hammerman; Craig Mermel; Alex H Ramos; Tanaz Sharifnia; Nicolas Stransky; Kumiko Elisa Tanaka; Ajit Chande; Jeonghee Cho; Matthew Meyerson
Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer.

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All Publications

2013: Grit S Herter-Sprie; Heidi Greulich; Kwok-Kin Wong
Activating Mutations in ERBB2 and Their Impact on Diagnostics and Treatment.
Frontiers in oncology 2013;3():86.
2012: Heidi Greulich; William C Hahn; Marcin Imielinski; Jacob D Jaffe; Bethany Kaplan; Michael S Lawrence; Se-Hoon Lee; Rachel Liao; D R Mani; Philipp Mertins; Lauren Ambrogio; Shantanu Banerji; Alice H Berger; Steven A Carr; Tzu-Hsiu Chen; Jeonghee Cho; Michael J Eck; David Frank; Gad Getz; Nam H Pho; Kumiko E Tanaka; Sarah R Walker; Wendy Winckler; Kwok-Kin Wong; Cai-Hong Yun; Jinghui Zhang; Xiaohong Zhang; Matthew Meyerson
Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(36):14476-81.
2011: Amit Dutt; Nathanael S Gray; Heidi Greulich; Peter S Hammerman; Craig Mermel; Alex H Ramos; Tanaz Sharifnia; Nicolas Stransky; Kumiko Elisa Tanaka; Ajit Chande; Jeonghee Cho; Matthew Meyerson
Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer.
PloS one 2011;6(6):e20351.
2010: Heidi Greulich
The genomics of lung adenocarcinoma: opportunities for targeted therapies.
Genes & cancer 2010;1(12):1200-10.
2010: Qing Sheng; Xinggang Liu; Eleanor Fleming; Karen Yuan; Huiying Piao; Jinyun Chen; Zeinab Moustafa; Roman K Thomas; Heidi Greulich; Anna Schinzel; Sara Zaghlul; David Batt; Seth Ettenberg; Matthew Meyerson; Birgit Schoeberl; Andrew L Kung; William C Hahn; Ronny Drapkin; David M Livingston; Joyce F Liu
An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells.
Cancer cell 2010;17(3):298-310.
2009: Samanthi A Perera; Danan Li; Takeshi Shimamura; Maria G Raso; Hongbin Ji; Liang Chen; Christa L Borgman; Sara Zaghlul; Kathleyn A Brandstetter; Shigeto Kubo; Masaya Takahashi; Lucian R Chirieac; Robert F Padera; Roderick T Bronson; Geoffrey I Shapiro; Heidi Greulich; Matthew Meyerson; Ulrich Guertler; Pilar Garin Chesa; Flavio Solca; Ignacio I Wistuba; Kwok-Kin Wong
HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(2):474-9.
2008: D Li; L Ambrogio; Takeshi Shimamura; S Kubo; M Takahashi; Lucian R Chirieac; Robert F Padera; Geoffrey I Shapiro; A Baum; F Himmelsbach; W J Rettig; Matthew Meyerson; F Solca; Heidi Greulich; Kwok-Kin Wong
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models.
Oncogene 2008;27(34):4702-11.
2008: Takeshi Shimamura; Danan Li; Hongbin Ji; Henry J Haringsma; Elizabeth Liniker; Christa L Borgman; April M Lowell; Yuko Minami; Kate McNamara; Samanthi A Perera; Sara Zaghlul; Roman K Thomas; Heidi Greulich; Susumu Kobayashi; Lucian R Chirieac; Robert F Padera; Shigeto Kubo; Masaya Takahashi; Daniel G Tenen; Matthew Meyerson; Kwok-Kin Wong; Geoffrey I Shapiro
Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance.
Cancer research 2008;68(14):5827-38.
2008: Amit Dutt; Helga B Salvesen; Tzu-Hsiu Chen; Alex H Ramos; Robert C Onofrio; Charlie Hatton; Richard Nicoletti; Wendy Winckler; Rupinder Grewal; Megan Hanna; Nicolas Wyhs; Liuda Ziaugra; Daniel J Richter; Jone Trovik; Ingeborg B Engelsen; Ingunn M Stefansson; Tim Fennell; Kristian Cibulskis; Michael C Zody; Lars A Akslen; Stacey Gabriel; Kwok-Kin Wong; William R Sellers; Matthew Meyerson; Heidi Greulich
Drug-sensitive FGFR2 mutations in endometrial carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(25):8713-7.
2008: Suzanne Schlisio; Rajappa S Kenchappa; Liesbeth C W Vredeveld; Rani E George; Rodney A Stewart; Heidi Greulich; Kristina Shahriari; Nguyen V Nguyen; Pascal Pigny; Patricia Dahia; Scott L Pomeroy; John M Maris; A Thomas Look; Matthew Meyerson; Daniel S Peeper; Bruce D Carter; William G Kaelin
The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor.
Genes & development 2008;22(7):884-93.
2008: Kenneth D Swanson; Jordan M Winter; Marcelo Reis; Mohamed Bentires-Alj; Heidi Greulich; Rupinder Grewal; Ralph Hruban; Charles J Yeo; Yosuf Yassin; Oleg Iartchouk; Kate Montgomery; Susan P Whitman; Michael A Caligiuri; Mignon L Loh; D Gary Gilliland; A Thomas Look; Raju Kucherlapati; Scott E Kern; Matthew Meyerson; Benjamin G Neel
SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients.
Genes, chromosomes & cancer 2008;47(3):253-9.
2008: Cai-Hong Yun; Kristen E Mengwasser; Angela V Toms; Michele S Woo; Heidi Greulich; Kwok-Kin Wong; Matthew Meyerson; Michael J Eck
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(6):2070-5.
2008: William M Lin; Alissa C Baker; Rameen Beroukhim; Wendy Winckler; Whei Feng; Jennifer M Marmion; Elisabeth Laine; Heidi Greulich; Hsiuyi Tseng; Casey Gates; F Stephen Hodi; Glenn Dranoff; William R Sellers; Roman K Thomas; Matthew Meyerson; Todd R Golub; Reinhard Dummer; Meenhard Herlyn; Gad Getz; Levi A Garraway
Modeling genomic diversity and tumor dependency in malignant melanoma.
Cancer research 2008;68(3):664-73.
2007: Jesse S Boehm; Jean J Zhao; Jun Yao; So Young Kim; Ron Firestein; Ian F Dunn; Sarah K Sjostrom; Levi A Garraway; Stanislawa Weremowicz; Andrea L Richardson; Heidi Greulich; Carly J Stewart; Laura A Mulvey; Rhine R Shen; Lauren Ambrogio; Tomoko Hirozane-Kishikawa; David E Hill; Marc Vidal; Matthew Meyerson; Jennifer K Grenier; Greg Hinkle; David E Root; Thomas M Roberts; Eric S Lander; Kornelia Polyak; William C Hahn
Integrative genomic approaches identify IKBKE as a breast cancer oncogene.
Cell 2007;129(6):1065-79.
2007: Yuki Yuza; Karen A Glatt; Jingrui Jiang; Heidi Greulich; Yuko Minami; Michele S Woo; Takeshi Shimamura; Geoffrey I Shapiro; Jeffrey C Lee; Hongbin Ji; Whei Feng; Tzu-Hsiu Chen; Haruhiko Yanagisawa; Kwok-Kin Wong; Matthew Meyerson
Allele-dependent variation in the relative cellular potency of distinct EGFR inhibitors.
Cancer biology & therapy 2007;6(5):661-7.
2007: Cai-Hong Yun; Titus Boggon; Yiqun Li; Michele S Woo; Heidi Greulich; Matthew Meyerson; Michael J Eck
Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity.
Cancer cell 2007;11(3):217-27.
2006: Takeshi Shimamura; Hongbin Ji; Yuko Minami; Roman K Thomas; April M Lowell; Kinjal Shah; Heidi Greulich; Karen A Glatt; Matthew Meyerson; Geoffrey I Shapiro; Kwok-Kin Wong
Non-small-cell lung cancer and Ba/F3 transformed cells harboring the ERBB2 G776insV_G/C mutation are sensitive to the dual-specific epidermal growth factor receptor and ERBB2 inhibitor HKI-272.
Cancer research 2006;66(13):6487-91.
2006: James V Alvarez; Heidi Greulich; William R Sellers; Matthew Meyerson; David A Frank
Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor.
Cancer research 2006;66(6):3162-8.
2005: Heidi Greulich; Tzu-Hsiu Chen; Whei Feng; Pasi A Janne; James V Alvarez; Mauro Zappaterra; Sara E Bulmer; David A Frank; William C Hahn; William R Sellers; Matthew Meyerson
Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants.
PLoS medicine 2005;2(11):e313.
2005: Jingrui Jiang; Heidi Greulich; Pasi A Janne; William R Sellers; Matthew Meyerson; James D Griffin
Epidermal growth factor-independent transformation of Ba/F3 cells with cancer-derived epidermal growth factor receptor mutants induces gefitinib-sensitive cell cycle progression.
Cancer research 2005;65(19):8968-74.
2005: Roman K Thomas; Heidi Greulich; Yuki Yuza; Jeffrey C Lee; Torstein Tengs; Whei Feng; Tzu-Hsiu Chen; E Nickerson; J Simons; Michael Egholm; Jonathan M Rothberg; William R Sellers; Matthew Meyerson
Detection of oncogenic mutations in the EGFR gene in lung adenocarcinoma with differential sensitivity to EGFR tyrosine kinase inhibitors.
Cold Spring Harbor symposia on quantitative biology 2005;70():73-81.
2004: J Guillermo Paez; Pasi A Janne; Jeffrey C Lee; Sean Tracy; Heidi Greulich; Stacey Gabriel; Paula Herman; Frederic J Kaye; Neal Lindeman; Titus Boggon; Katsuhiko Naoki; Hidefumi Sasaki; Yoshitaka Fujii; Michael J Eck; William R Sellers; Bruce E Johnson; Matthew Meyerson
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.
Science (New York, N.Y.) 2004;304(5676):1497-500.