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Kai Griebenow

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TOP 3
Brenda L Montalvo-Ortiz; Brian Sosa; Kai Griebenow
Improved enzyme activity and stability in polymer microspheres by encapsulation of protein nanospheres.
José A Rodríguez-Martínez; Izarys Rivera-Rivera; Kai Griebenow
Prevention of benzyl alcohol-induced aggregation of chymotrypsinogen by PEGylation.
Ricardo J Solá; Kai Griebenow
Glycosylation of therapeutic proteins: an effective strategy to optimize efficacy.

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All Publications

2012: Brenda L Montalvo-Ortiz; Brian Sosa; Kai Griebenow
Improved enzyme activity and stability in polymer microspheres by encapsulation of protein nanospheres.
AAPS PharmSciTech 2012;13(2):632-6.
2011: José A Rodríguez-Martínez; Izarys Rivera-Rivera; Kai Griebenow
Prevention of benzyl alcohol-induced aggregation of chymotrypsinogen by PEGylation.
The Journal of pharmacy and pharmacology 2011;63(6):800-5.
2010: Ricardo J Solá; Kai Griebenow
Glycosylation of therapeutic proteins: an effective strategy to optimize efficacy.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2010;24(1):9-21.
2010: Giselle M Flores-Fernández; Miraida Pagan; Mariangely Almenas; Ricardo J Solá; Kai Griebenow
Moisture-induced solid state instabilities in alpha-chymotrypsin and their reduction through chemical glycosylation.
BMC biotechnology 2010;10():57.
2009: Giselle M Flores-Fernández; Ricardo J Solá; Kai Griebenow
The relation between moisture-induced aggregation and structural changes in lyophilized insulin.
The Journal of pharmacy and pharmacology 2009;61(11):1555-61.
2009: José A Rodríguez-Martínez; Izarys Rivera-Rivera; Ricardo J Solá; Kai Griebenow
Enzymatic activity and thermal stability of PEG-alpha-chymotrypsin conjugates.
Biotechnology letters 2009;31(6):883-7.
2009: Miraida Pagan; Ricardo J Solá; Kai Griebenow
On the role of protein structural dynamics in the catalytic activity and thermostability of serine protease subtilisin Carlsberg.
Biotechnology and bioengineering 2009;103(1):77-84.
2009: Ricardo J Solá; Kai Griebenow
Effects of glycosylation on the stability of protein pharmaceuticals.
Journal of pharmaceutical sciences 2009;98(4):1223-45.
2008: José A Rodríguez-Martínez; Ricardo J Solá; Betzaida Castillo; Héctor R Cintrón-Colón; Izarys Rivera-Rivera; Gabriel Barletta; Kai Griebenow
Stabilization of alpha-chymotrypsin upon PEGylation correlates with reduced structural dynamics.
Biotechnology and bioengineering 2008;101(6):1142-9.
2008: Brenda L Montalvo; Yamaris Pacheco; Giselle Sánchez; Brian A Sosa; Denisse Vélez; Kai Griebenow
Formation of spherical protein nanoparticles without impacting protein integrity.
Nanotechnology 2008;19(46):465103.
2008: Betzaida Castillo; Ricardo J Solá; Amaris Ferrer; Gabriel Barletta; Kai Griebenow
Effect of PEG modification on subtilisin Carlsberg activity, enantioselectivity, and structural dynamics in 1,4-dioxane.
Biotechnology and bioengineering 2008;99(1):9-17.
2007: Ricardo J Solá; J A Rodríguez-Martínez; Kai Griebenow
Modulation of protein biophysical properties by chemical glycosylation: biochemical insights and biomedical implications.
Cellular and molecular life sciences : CMLS 2007;64(16):2133-52.
2007: Reinhard Schweitzer-Stenner; Thomas Measey; Lazaros Kakalis; Frank Jordan; Silvia Pizzanelli; Claudia Forte; Kai Griebenow
Conformations of alanine-based peptides in water probed by FTIR, Raman, vibrational circular dichroism, electronic circular dichroism, and NMR spectroscopy.
Biochemistry 2007;46(6):1587-96.
2006: Ricardo J Solá; Kai Griebenow
Influence of modulated structural dynamics on the kinetics of alpha-chymotrypsin catalysis. Insights through chemical glycosylation, molecular dynamics and domain motion analysis.
The FEBS journal 2006;273(23):5303-19.
2006: Ricardo J Solá; Wasfi Al-Azzam; Kai Griebenow
Engineering of protein thermodynamic, kinetic, and colloidal stability: Chemical Glycosylation with monofunctionally activated glycans.
Biotechnology and bioengineering 2006;94(6):1072-9.
2006: Betzaida Castillo; Jessica Méndez; Wasfi Al-Azzam; Gabriel Barletta; Kai Griebenow
On the relationship between the activity and structure of PEG-alpha-chymotrypsin conjugates in organic solvents.
Biotechnology and bioengineering 2006;94(3):565-74.
2006: Andrew Hagarman; Thomas Measey; Ravi S Doddasomayajula; Isabelle Dragomir; Fatma Eker; Kai Griebenow; Reinhard Schweitzer-Stenner
Conformational analysis of XA and AX dipeptides in water by electronic circular dichroism and 1H NMR spectroscopy.
The journal of physical chemistry. B 2006;110(13):6979-86.
2006: Ingrid J Castellanos; Giselle Flores; Kai Griebenow
Effect of cyclodextrins on alpha-chymotrypsin stability and loading in PLGA microspheres upon S/O/W encapsulation.
Journal of pharmaceutical sciences 2006;95(4):849-58.
2006: Reinhard Schweitzer-Stenner; Thomas Measey; Andrew Hagarman; Fatma Eker; Kai Griebenow
Salmon calcitonin and amyloid beta: two peptides with amyloidogenic capacity adopt different conformational manifolds in their unfolded states.
Biochemistry 2006;45(9):2810-9.
2006: Ricardo J Solá; Kai Griebenow
Chemical glycosylation: new insights on the interrelation between protein structural mobility, thermodynamic stability, and catalysis.
FEBS letters 2006;580(6):1685-90.
2006: Betzaida Castillo; Vibha Bansal; Ashok Ganesan; Peter J Halling; Francesco Secundo; Amaris Ferrer; Kai Griebenow; Gabriel Barletta
On the activity loss of hydrolases in organic solvents: II. a mechanistic study of subtilisin Carlsberg.
BMC biotechnology 2006;6():51.
2005: Ingrid J Castellanos; Giselle Flores; Kai Griebenow
Effect of the molecular weight of poly(ethylene glycol) used as emulsifier on alpha-chymotrypsin stability upon encapsulation in PLGA microspheres.
The Journal of pharmacy and pharmacology 2005;57(10):1261-69.
2005: Wasfi Al-Azzam; Emil A Pastrana; Brian King; Jessica Méndez; Kai Griebenow
Effect of the covalent modification of horseradish peroxidase with poly(ethylene glycol) on the activity and stability upon encapsulation in polyester microspheres.
Journal of pharmaceutical sciences 2005;94(8):1808-19.
2005: Thomas Measey; Andrew Hagarman; Fatma Eker; Kai Griebenow; Reinhard Schweitzer-Stenner
Side chain dependence of intensity and wavenumber position of amide I' in IR and visible Raman spectra of XA and AX dipeptides.
The journal of physical chemistry. B 2005;109(16):8195-205.
2005: Qing Huang; Qingguo Huang; Roger A Pinto; Kai Griebenow; Reinhard Schweitzer-Stenner; Walter J Weber
Inactivation of horseradish peroxidase by phenoxyl radical attack.
Journal of the American Chemical Society 2005;127(5):1431-7.
2005: Ingrid J Castellanos; Wasfi Al-Azzam; Kai Griebenow
Effect of the covalent modification with poly(ethylene glycol) on alpha-chymotrypsin stability upon encapsulation in poly(lactic-co-glycolic) microspheres.
Journal of pharmaceutical sciences 2005;94(2):327-40.
2004: Fatma Eker; Kai Griebenow; Xiaolin Cao; Laurence A Nafie; Reinhard Schweitzer-Stenner
Preferred peptide backbone conformations in the unfolded state revealed by the structure analysis of alanine-based (AXA) tripeptides in aqueous solution.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(27):10054-9.
2004: Fatma Eker; Kai Griebenow; Reinhard Schweitzer-Stenner
Abeta(1-28) fragment of the amyloid peptide predominantly adopts a polyproline II conformation in an acidic solution.
Biochemistry 2004;43(22):6893-8.
2004: Reinhard Schweitzer-Stenner; Fatma Eker; Kai Griebenow; Xiaolin Cao; Laurence A Nafie
The conformation of tetraalanine in water determined by polarized Raman, FT-IR, and VCD spectroscopy.
Journal of the American Chemical Society 2004;126(9):2768-76.
2004: Fatma Eker; Kai Griebenow; Xiaolin Cao; Laurence A Nafie; Reinhard Schweitzer-Stenner
Tripeptides with ionizable side chains adopt a perturbed polyproline II structure in water.
Biochemistry 2004;43(3):613-21.
2003: Angelica Santos; Maryliz González; Yamaris Pacheco; Kai Griebenow
Comparison of theoretical and experimental data to evaluate substrate diffusional limitations for crown ether- and methyl-beta-cyclodextrin-activated serine protease subtilisin Carlsberg in tetrahydrofuran.
Biotechnology and bioengineering 2003;84(3):324-31.
2003: Ingrid J Castellanos; Kai Griebenow
Improved alpha-chymotrypsin stability upon encapsulation in PLGA microspheres by solvent replacement.
Pharmaceutical research 2003;20(11):1873-80.
2003: Fatma Eker; Kai Griebenow; Reinhard Schweitzer-Stenner
Stable conformations of tripeptides in aqueous solution studied by UV circular dichroism spectroscopy.
Journal of the American Chemical Society 2003;125(27):8178-85.
2003: Caroline Pérez; Kai Griebenow
Effect of salts on lysozyme stability at the water-oil interface and upon encapsulation in poly(lactic-co-glycolic) acid microspheres.
Biotechnology and bioengineering 2003;82(7):825-32.
2003: Qing Huang; Wasfi Al-Azzam; Kai Griebenow; Reinhard Schweitzer-Stenner
Heme structural perturbation of PEG-modified horseradish peroxidase C in aromatic organic solvents probed by optical absorption and resonance Raman dispersion spectroscopy.
Biophysical journal 2003;84(5):3285-98.
2003: Caroline Pérez-Rodriguez; Nashbly Montano; Karilys Gonzalez; Kai Griebenow
Stabilization of alpha-chymotrypsin at the CH2Cl2/water interface and upon water-in-oil-in-water encapsulation in PLGA microspheres.
Journal of controlled release : official journal of the Controlled Release Society 2003;89(1):71-85.
2003: Ingrid J Castellanos; Rubén Crespo; Kai Griebenow
Poly(ethylene glycol) as stabilizer and emulsifying agent: a novel stabilization approach preventing aggregation and inactivation of proteins upon encapsulation in bioerodible polyester microspheres.
Journal of controlled release : official journal of the Controlled Release Society 2003;88(1):135-45.
2003: Reinhard Schweitzer-Stenner; Fatma Eker; Alejandro Perez; Kai Griebenow; Xiaolin Cao; Laurence A Nafie
The structure of tri-proline in water probed by polarized Raman, Fourier transform infrared, vibrational circular dichroism, and electric ultraviolet circular dichroism spectroscopy.
Biopolymers 2003;71(5):558-68.
2002: Wasfi Al-Azzam; Emil A Pastrana; Yancy Ferrer; Qing Huang; Reinhard Schweitzer-Stenner; Kai Griebenow
Structure of poly(ethylene glycol)-modified horseradish peroxidase in organic solvents: infrared amide I spectral changes upon protein dehydration are largely caused by protein structural changes and not by water removal per se.
Biophysical journal 2002;83(6):3637-51.
2002: Caroline Pérez; Patricia De Jesús; Kai Griebenow
Preservation of lysozyme structure and function upon encapsulation and release from poly(lactic-co-glycolic) acid microspheres prepared by the water-in-oil-in-water method.
International journal of pharmaceutics 2002;248(1-2):193-206.
2002: Ingrid J Castellanos; Gloydian Cruz; Rubén Crespo; Kai Griebenow
Encapsulation-induced aggregation and loss in activity of gamma-chymotrypsin and their prevention.
Journal of controlled release : official journal of the Controlled Release Society 2002;81(3):307-19.
2002: Caroline Pérez; Ingrid J Castellanos; Henry R Costantino; Wasfi Al-Azzam; Kai Griebenow
Recent trends in stabilizing protein structure upon encapsulation and release from bioerodible polymers.
The Journal of pharmacy and pharmacology 2002;54(3):301-13.
2002: Henry R Costantino; Laleh Firouzabadian; Chichih Wu; Karen G Carrasquillo; Kai Griebenow; Stephen E Zale; Mark A Tracy
Protein spray freeze drying. 2. Effect of formulation variables on particle size and stability.
Journal of pharmaceutical sciences 2002;91(2):388-95.
2001: Karen G Carrasquillo; A M Stanley; J C Aponte-Carro; P De Jésus; Henry R Costantino; C J Bosques; Kai Griebenow
Non-aqueous encapsulation of excipient-stabilized spray-freeze dried BSA into poly(lactide-co-glycolide) microspheres results in release of native protein.
Journal of controlled release : official journal of the Controlled Release Society 2001;76(3):199-208.
2001: Reinhard Schweitzer-Stenner; Fatma Eker; Qing Huang; Kai Griebenow
Dihedral angles of trialanine in D2O determined by combining FTIR and polarized visible Raman spectroscopy.
Journal of the American Chemical Society 2001;123(39):9628-33.
2001: C Pérez; Kai Griebenow
Improved activity and stability of lysozyme at the water/CH2Cl2 interface: enzyme unfolding and aggregation and its prevention by polyols.
The Journal of pharmacy and pharmacology 2001;53(9):1217-26.
2001: Angelica Santos; M Vidal; Y Pacheco; J Frontera; C Báez; O Ornellas; Gabriel Barletta; Kai Griebenow
Effect of crown ethers on structure, stability, activity, and enantioselectivity of subtilisin Carlsberg in organic solvents.
Biotechnology and bioengineering 2001;74(4):295-308.
2001: Ingrid J Castellanos; W O Cuadrado; Kai Griebenow
Prevention of structural perturbations and aggregation upon encapsulation of bovine serum albumin into poly(lactide-co-glycolide) micropheres using the solid-in-oil-in water technique.
The Journal of pharmacy and pharmacology 2001;53(8):1099-107.
2001: Kai Griebenow; M Vidal; C Baéz; Angelica Santos; Gabriel Barletta
Nativelike enzyme properties are important for optimum activity in neat organic solvents.
Journal of the American Chemical Society 2001;123(22):5380-1.
2001: Ingrid J Castellanos; Karen G Carrasquillo; J D López; M Alvarez; Kai Griebenow
Encapsulation of bovine serum albumin in poly(lactide-co-glycolide) microspheres by the solid-in-oil-in-water technique.
The Journal of pharmacy and pharmacology 2001;53(2):167-78.
2001: Karen G Carrasquillo; J C Carro; A Alejandro; D D Toro; Kai Griebenow
Reduction of structural perturbations in bovine serum albumin by non-aqueous microencapsulation.
The Journal of pharmacy and pharmacology 2001;53(1):115-20.
2000: Henry R Costantino; Laleh Firouzabadian; K Hogeland; C Wu; C Beganski; Karen G Carrasquillo; M Córdova; Kai Griebenow; Stephen E Zale; Mark A Tracy
Protein spray-freeze drying. Effect of atomization conditions on particle size and stability.
Pharmaceutical research 2000;17(11):1374-83.
2000: Karen G Carrasquillo; C Sanchez; Kai Griebenow
Relationship between conformational stability and lyophilization-induced structural changes in chymotrypsin.
Biotechnology and applied biochemistry 2000;31 ( Pt 1)():41-53.
1999: Karen G Carrasquillo; Henry R Costantino; R A Cordero; Chung C Hsu; Kai Griebenow
On the structural preservation of recombinant human growth hormone in a dried film of a synthetic biodegradable polymer.
Journal of pharmaceutical sciences 1999;88(2):166-73.
1998: Henry R Costantino; Karen G Carrasquillo; R A Cordero; M Mumenthaler; Chung C Hsu; Kai Griebenow
Effect of excipients on the stability and structure of lyophilized recombinant human growth hormone.
Journal of pharmaceutical sciences 1998;87(11):1412-20.
1997: K Xu; Kai Griebenow; Alexander M Klibanov
Correlation between catalytic activity and secondary structure of subtilisin dissolved in organic solvents.
Biotechnology and bioengineering 1997;56(5):485-91.
1997: Kai Griebenow; Alexander M Klibanov
Can conformational changes be responsible for solvent and excipient effects on the catalytic behavior of subtilisin Carlsberg in organic solvents?
Biotechnology and bioengineering 1997;53(4):351-62.
1997: Henry R Costantino; Kai Griebenow; R Langer; Alexander M Klibanov
On the pH memory of lyophilized compounds containing protein functional groups.
Biotechnology and bioengineering 1997;53(3):345-8.
1996: P Mishra; Kai Griebenow; Alexander M Klibanov
Structural basis for the molecular memory of imprinted proteins in anhydrous media.
Biotechnology and bioengineering 1996;52(5):609-14.
1996: Henry R Costantino; S P Schwendeman; Kai Griebenow; Alexander M Klibanov; Robert Langer
The secondary structure and aggregation of lyophilized tetanus toxoid.
Journal of pharmaceutical sciences 1996;85(12):1290-3.
1995: Kai Griebenow; Alexander M Klibanov
Lyophilization-induced reversible changes in the secondary structure of proteins.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(24):10969-76.
1995: Henry R Costantino; Kai Griebenow; P Mishra; Robert Langer; Alexander M Klibanov
Fourier-transform infrared spectroscopic investigation of protein stability in the lyophilized form.
Biochimica et biophysica acta 1995;1253(1):69-74.