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David Grierson

Research Profile

Genes & Molecular Sequences

Molecular Structure

Concepts & Ideas

Living Beings

HIV-1

Chemicals & Drugs

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Publications

TOP 3
Jérôme Guillemont; Abdellah Benjahad; Said Oumouch; Laurence Decrane; Patrice Palandjian; Daniel Vernier; Laurence Queguiner; Koen Andries; Marie-Pierre de Bethune; Kurt Hertogs; David S Grierson; Chi Hung Nguyen
Synthesis and biological evaluation of C-5 methyl substituted 4-arylthio and 4-aryloxy-3-Iodopyridin-2(1H)-one type anti-HIV agents.
François Besselièvre; Sandrine Piguel; Florence Mahuteau-Betzer; David S Grierson
Stereoselective direct copper-catalyzed alkenylation of oxazoles with bromoalkenes.
François Besselièvre; Florence Mahuteau-Betzer; David S Grierson; Sandrine Piguel
Ligandless microwave-assisted Pd/Cu-catalyzed direct arylation of oxazoles.

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All Publications

2009: Jérôme Guillemont; Abdellah Benjahad; Said Oumouch; Laurence Decrane; Patrice Palandjian; Daniel Vernier; Laurence Queguiner; Koen Andries; Marie-Pierre de Bethune; Kurt Hertogs; David S Grierson; Chi Hung Nguyen
Synthesis and biological evaluation of C-5 methyl substituted 4-arylthio and 4-aryloxy-3-Iodopyridin-2(1H)-one type anti-HIV agents.
Journal of medicinal chemistry 2009;52(23):7473-87.
2008: François Besselièvre; Sandrine Piguel; Florence Mahuteau-Betzer; David S Grierson
Stereoselective direct copper-catalyzed alkenylation of oxazoles with bromoalkenes.
Organic letters 2008;10(18):4029-32.
2008: François Besselièvre; Florence Mahuteau-Betzer; David S Grierson; Sandrine Piguel
Ligandless microwave-assisted Pd/Cu-catalyzed direct arylation of oxazoles.
The Journal of organic chemistry 2008;73(8):3278-80.
2008: Mohamed Amessou; Danièle Carrez; Delphine Patin; Marianne Sarr; David S Grierson; Alain Croisy; Antonio C Tedesco; Philippe Maillard; Ludger Johannes
Retrograde delivery of photosensitizer (TPPp-O-beta-GluOH)3 selectively potentiates its photodynamic activity.
Bioconjugate chemistry 2008;19(2):532-8.
2007: Nadia Bakkour; Yea-Lih Lin; Sophie Maire; Lilia Ayadi; Florence Mahuteau-Betzer; Chi Hung Nguyen; Clément Mettling; Pierre Portales; David S Grierson; Benoit Chabot; Philippe Jeanteur; Christiane Branlant; Pierre Corbeau; Jamal Tazi
Small-molecule inhibition of HIV pre-mRNA splicing as a novel antiretroviral therapy to overcome drug resistance.
PLoS pathogens 2007;3(10):1530-9.
2007: Sébastien Durand; Nicolas Cougot; Florence Mahuteau-Betzer; Chi Hung Nguyen; David S Grierson; Edouard Bertrand; Jamal Tazi; Fabrice Lejeune
Inhibition of nonsense-mediated mRNA decay (NMD) by a new chemical molecule reveals the dynamic of NMD factors in P-bodies.
The Journal of cell biology 2007;178(7):1145-60.
2007: Abdellah Benjahad; Said Oumouch; Jérôme Guillemont; Elisabeth Pasquier; Dominique Mabire; Koen Andries; Chi Hung Nguyen; David S Grierson
Structure-activity relationship in the 3-iodo-4-phenoxypyridinone (IOPY) series: The nature of the C-3 substituent on anti-HIV activity.
Bioorganic & medicinal chemistry letters 2007;17(3):712-6.
2007: Lucie Vandromme; Michel Legraverend; Sergio Kreimerman; Olivier Lozach; Laurent Meijer; David S Grierson
A Pd(0) based cross-coupling approach to the synthesis of 2-amidopurines and their evaluation as CDK inhibitors.
Bioorganic & medicinal chemistry 2007;15(1):130-41.
2006: Lucie Vandromme; Sandrine Piguel; Olivier Lozach; Laurent Meijer; Michel Legraverend; David S Grierson
Suzuki-type Pd(0) coupling reactions in the synthesis of 2-arylpurines as Cdk inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(12):3144-6.
2006: Michel Legraverend; David S Grierson
The purines: potent and versatile small molecule inhibitors and modulators of key biological targets.
Bioorganic & medicinal chemistry 2006;14(12):3987-4006.
2006: Alexandra Erve; Yasmina Saoudi; Sylvie Thirot; Corinne Guetta-Landras; Jean-Claude Florent; Chi Hung Nguyen; David S Grierson; Andrei V Popov
BENA435, a new cell-permeant photoactivated green fluorescent DNA probe.
Nucleic acids research 2006;34(5):e43.
2005: Daniel M Himmel; Kalyan Das; Arthur D Clark; Stephen H Hughes; Abdellah Benjahad; Said Oumouch; Jérôme Guillemont; Sophie Coupa; Alain PONCELET; Imre Csoka; Christophe Meyer; Koen Andries; Chi Hung Nguyen; David S Grierson; Eddy Arnold
Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains.
Journal of medicinal chemistry 2005;48(24):7582-91.
2005: Haleh Amiri; Natalia Nekhotiaeva; Jian-Sheng Sun; Chi Hung Nguyen; David S Grierson; Liam Good; Rula Zain
Benzoquinoquinoxaline derivatives stabilize and cleave H-DNA and repress transcription downstream of a triplex-forming sequence.
Journal of molecular biology 2005;351(4):776-83.
2005: Abdellah Benjahad; Martine Croisy; Claude Monneret; Emile Bisagni; Dominique Mabire; Sophie Coupa; Alain PONCELET; Imre Csoka; Jérôme Guillemont; Christophe Meyer; Koen Andries; Rudi Pauwels; Marie-Pierre de Bethune; Daniel M Himmel; Kalyan Das; Eddy Arnold; Chi Hung Nguyen; David S Grierson
4-Benzyl and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones: in vitro evaluation of new C-3-amino-substituted and C-5,6-alkyl-substituted analogues against clinically important HIV mutant strains.
Journal of medicinal chemistry 2005;48(6):1948-64.
2004: Ahmed Zaid; Jian-Sheng Sun; Chi Hung Nguyen; Emile Bisagni; Thérèse Garestier; David S Grierson; Rula Zain
Triple-helix directed cleavage of double-stranded DNA by benzoquinoquinoxaline-1,10-phenanthroline conjugates.
Chembiochem : a European journal of chemical biology 2004;5(11):1550-7.
2004: Abdellah Benjahad; Karine Courté; Jérôme Guillemont; Dominique Mabire; Sophie Coupa; Alain PONCELET; Imre Csoka; Koen Andries; Rudi Pauwels; Marie-Pierre de Bethune; Claude Monneret; Emile Bisagni; Chi Hung Nguyen; David S Grierson
4-benzyl- and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones, a new family of potent anti-HIV agents: optimization and in vitro evaluation against clinically important HIV mutant strains.
Journal of medicinal chemistry 2004;47(22):5501-14.
2003: Abdellah Benjahad; Jérôme Guillemont; Koen Andries; Chi Hung Nguyen; David S Grierson
3-iodo-4-phenoxypyridinones (IOPY's), a new family of highly potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorganic & medicinal chemistry letters 2003;13(24):4309-12.
2003: Rula Zain; David Polverari; Chi Hung Nguyen; Yves Blouquit; Emile Bisagni; Thérèse Garestier; David S Grierson; Jian-Sheng Sun
Optimization of triple-helix-directed DNA cleavage by benzoquinoquinoxaline-ethylenediaminetetraacetic acid conjugates.
Chembiochem : a European journal of chemical biology 2003;4(9):856-62.
2002: Patrizia Alberti; Philippe Schmitt; Chi Hung Nguyen; Christian Rivalle; Magali Hoarau; David S Grierson; Jean-Louis Mergny
Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase.
Bioorganic & medicinal chemistry letters 2002;12(7):1071-4.
2000: Pierre Ducrot; Michel Legraverend; David S Grierson
3D-QSAR CoMFA on cyclin-dependent kinase inhibitors.
Journal of medicinal chemistry 2000;43(22):4098-108.
2000: Renée Pontikis; Valérie Dollé; Jean Guillaumel; Elsa Dechaux; R Note; Chi Hung Nguyen; Michel Legraverend; Emile Bisagni; AM Aubertin; David S Grierson; Claude Monneret
Synthesis and evaluation of "AZT-HEPT", "AZT-pyridinone", and "ddC-HEPT" conjugates as inhibitors of HIV reverse transcriptase.
Journal of medicinal chemistry 2000;43(10):1927-39.
2000: Michel Legraverend; P Tunnah; M Noble; Pierre Ducrot; O Ludwig; David S Grierson; Maryse Leost; Laurent Meijer; J Endicott
Cyclin-dependent kinase inhibition by new C-2 alkynylated purine derivatives and molecular structure of a CDK2-inhibitor complex.
Journal of medicinal chemistry 2000;43(7):1282-92.
1999: Renée Pontikis; R Note; Elsa Dechaux; Jean Guillaumel; AM Aubertin; David S Grierson; Claude Monneret
"Mixed inhibitors" of HIV-reverse transcriptase: synthesis and antiviral activity.
Nucleosides & nucleotides 1999;18(4-5):707-8.
1998: D R Adams; A S Boyd; R Ferguson; David S Grierson; Claude Monneret
Heterocyclic nucleoside analogues by cycloaddition reactions of 1-vinylthymine with 1,3-dipoles.
Nucleosides & nucleotides 1998;17(6):1053-75.
1997: Renée Pontikis; R Benhida; AM Aubertin; David S Grierson; Claude Monneret
Synthesis and anti-HIV activity of novel N-1 side chain-modified analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).
Journal of medicinal chemistry 1997;40(12):1845-54.
1997: D R Adams; C Perez; M Maillard; Jean-Claude Florent; M Evers; Y Hénin; S Litvak; L Litvak; Claude Monneret; David S Grierson
Preparation and anti-HIV activity of N-3-substituted thymidine nucleoside analogs.
Journal of medicinal chemistry 1997;40(10):1550-8.