Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

James Griffin

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Living Beings

Mice

Anatomy

Phenomena

Phosphorylation

Disorders

Physiology

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
33
Sattler, Martin
33
Salgia, Ravi
26
Druker, Brian
26
Gilliland, Gary
23
Weisberg, Ellen
19
Cannistra, Stephen
14
Nadler, Lee
13
Demetri, George
13
Fabbro, Doriano
12
Stone, Richard
10
Ritz, Jerome
10
Kufe, Donald
9
Manley, Paul
9
Pisick, Evan
9
Ray, Arghya

Sign-in to see all Coauthors

Publications

TOP 3
Sattler Martin; Griffin James D
JAK2 gets histone H3 rolling.
Fernandes Margret S; Reddy Mamatha M; Gonneville Jeffrey R; DeRoo Scott C; Podar Klaus; Griffin James D; Weinstock David M; Sattler Martin
BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair.
Weisberg Ellen; Barrett Rosemary; Liu Qingsong; Stone Richard; Gray Nathanael; Griffin James D
FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of James Griffin (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Sattler Martin; Griffin James D
JAK2 gets histone H3 rolling.
Cancer cell 2009;16(5):365-6.
2009: Fernandes Margret S; Reddy Mamatha M; Gonneville Jeffrey R; DeRoo Scott C; Podar Klaus; Griffin James D; Weinstock David M; Sattler Martin
BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair.
Blood 2009;114(9):1813-9.
2009: Weisberg Ellen; Barrett Rosemary; Liu Qingsong; Stone Richard; Gray Nathanael; Griffin James D
FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2009;12(3):81-9.
2008: Weisberg Ellen; Roesel Johannes; Bold Guido; Furet Pascal; Jiang Jingrui; Cools Jan; Wright Renee D; Nelson Erik; Barrett Rosemary; Ray Arghya; Moreno Daisy; Hall-Meyers Elizabeth; Stone Richard; Galinsky Ilene; Fox Edward; Gilliland Gary; Daley John F; Lazo-Kallanian Suzan; Kung Andrew L; Griffin James D
Antileukemic effects of the novel, mutant FLT3 inhibitor NVP-AST487: effects on PKC412-sensitive and -resistant FLT3-expressing cells.
Blood 2008;112(13):5161-70.
2008: Weisberg Ellen; Wright Renee D; McMillin Douglas W; Mitsiades Constantine; Ray Arghya; Barrett Rosemary; Adamia Sophia; Stone Richard; Galinsky Ilene; Kung Andrew L; Griffin James D
Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells.
Molecular cancer therapeutics 2008;7(5):1121-9.
2008: Loriaux Marc M; Levine Ross L; Tyner Jeffrey W; Fröhling Stefan; Scholl Claudia; Stoffregen Eric P; Wernig Gerlinde; Erickson Heidi; Eide Christopher A; Berger Roland; Bernard Olivier A; Griffin James D; Stone Richard M; Lee Benjamin; Meyerson Matthew; Heinrich Michael C; Deininger Michael W; Gilliland D Gary; Druker Brian J
High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia.
Blood 2008;111(9):4788-96.
2008: Wernig Gerlinde; Gonneville Jeffrey R; Crowley Brian J; Rodrigues Margret S; Reddy Mamatha M; Hudon Heidi E; Walz Christoph; Reiter Andreas; Podar Klaus; Royer Yohan; Constantinescu Stefan N; Tomasson Michael H; Griffin James D; Gilliland D Gary; Sattler Martin
The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes.
Blood 2008;111(7):3751-9.
2008: Weisberg Ellen; Banerji Lolita; Wright Renee D; Barrett Rosemary; Ray Arghya; Moreno Daisy; Catley Laurence; Jiang Jingrui; Hall-Meyers Elizabeth; Sauveur-Michel Maira; Stone Richard; Galinsky Ilene; Fox Edward; Kung Andrew L; Griffin James D
Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells.
Blood 2008;111(7):3723-34.
2007: Fröhling Stefan; Scholl Claudia; Levine Ross L; Loriaux Marc; Boggon Titus J; Bernard Olivier A; Berger Roland; Döhner Hartmut; Döhner Konstanze; Ebert Benjamin L; Teckie Sewit; Golub Todd R; Jiang Jingrui; Schittenhelm Marcus M; Lee Benjamin H; Griffin James D; Stone Richard M; Heinrich Michael C; Deininger Michael W; Druker Brian J; Gilliland D Gary
Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles.
Cancer cell 2007;12(6):501-13.
2007: Wu Lizi; Maillard Ivan; Nakamura Makoto; Pear Warren S; Griffin James D
The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development.
Blood 2007;110(10):3618-23.
2007: Weisberg Ellen; Kung Andrew L; Wright Renee D; Moreno Daisy; Catley Laurie; Ray Arghya; Zawel Leigh; Tran Mary; Cools Jan; Gilliland Gary; Mitsiades Constantine; McMillin Douglas W; Jiang Jingrui; Hall-Meyers Elizabeth; Griffin James D
Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells.
Molecular cancer therapeutics 2007;6(7):1951-61.
2007: Ray Arghya; Cowan-Jacob Sandra W; Manley Paul W; Mestan Jürgen; Griffin James D
Identification of BCR-ABL point mutations conferring resistance to the Abl kinase inhibitor AMN107 (nilotinib) by a random mutagenesis study.
Blood 2007;109(11):5011-5.
2007: Weisberg Ellen; Manley Paul W; Cowan-Jacob Sandra W; Hochhaus Andreas; Griffin James D
Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia.
Nature reviews. Cancer 2007;7(5):345-56.
2007: Zhao Yongtong; Katzman Rebecca B; Delmolino Laurie M; Bhat Ishfaq; Zhang Ying; Gurumurthy Channabasavaiah B; Germaniuk-Kurowska Aleksandra; Reddi Honey V; Solomon Aharon; Zeng Mu-Sheng; Kung Aisha; Ma Hui; Gao Qingshen; Dimri Goberdhan; Stanculescu Adina; Miele Lucio; Wu Lizi; Griffin James D; Wazer David E; Band Hamid; Band Vimla
The notch regulator MAML1 interacts with p53 and functions as a coactivator.
The Journal of biological chemistry 2007;282(16):11969-81.
2007: Zhang Hongbing; Bajraszewski Natalia; Wu Erxi; Wang Hongwei; Moseman Annie P; Dabora Sandra L; Griffin James D; Kwiatkowski David J
PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR.
The Journal of clinical investigation 2007;117(3):730-8.
2007: Chen J; Jette C; Kanki J P; Aster J C; Look A T; Griffin J D
NOTCH1-induced T-cell leukemia in transgenic zebrafish.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007;21(3):462-71.
2007: Weisberg Ellen; Catley Laurie; Wright Renee D; Moreno Daisy; Banerji Lolita; Ray Arghya; Manley Paul W; Mestan Juergen; Fabbro Doriano; Jiang Jingrui; Hall-Meyers Elizabeth; Callahan Linda; DellaGatta Jamie L; Kung Andrew L; Griffin James D
Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias.
Blood 2007;109(5):2112-20.
2006: Weisberg Ellen; Wright Renee D; Jiang Jingrui; Ray Arghya; Moreno Daisy; Manley Paul W; Fabbro Doriano; Hall-Meyers Elizabeth; Catley Laurie; Podar Klaus; Kung Andrew L; Griffin James D
Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity.
Gastroenterology 2006;131(6):1734-42.
2006: Kantarjian Hagop; Giles Francis; Wunderle Lydia; Bhalla Kapil; O'Brien Susan; Wassmann Barbara; Tanaka Chiaki; Manley Paul; Rae Patricia; Mietlowski William; Bochinski Kathy; Hochhaus Andreas; Griffin James D; Hoelzer Dieter; Albitar Maher; Dugan Margaret; Cortes Jorge; Alland Leila; Ottmann Oliver G
Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL.
The New England journal of medicine 2006;354(24):2542-51.
2006: Weisberg E; Manley P; Mestan J; Cowan-Jacob S; Ray A; Griffin J D
AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL.
British journal of cancer 2006;94(12):1765-9.
2006: Walz Christoph; Crowley Brian J; Hudon Heidi E; Gramlich Jessica L; Neuberg Donna S; Podar Klaus; Griffin James D; Sattler Martin
Activated Jak2 with the V617F point mutation promotes G1/S phase transition.
The Journal of biological chemistry 2006;281(26):18177-83.
2006: Shen Huangxuan; McElhinny Abigail S; Cao Yang; Gao Ping; Liu Jingxuan; Bronson Roderick; Griffin James D; Wu Lizi
The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis.
Genes & development 2006;20(6):675-88.
2006: Sattler Martin; Walz Christoph; Crowley Brian J; Lengfelder Eva; Jänne Pasi A; Rogers Andrew M; Kuang Yanan; Distel Robert J; Reiter Andreas; Griffin James D
A sensitive high-throughput method to detect activating mutations of Jak2 in peripheral-blood samples.
Blood 2006;107(3):1237-8.
2005: Chen Jing; Lee Benjamin H; Williams Ifor R; Kutok Jeffery L; Mitsiades Constantine S; Duclos Nicole; Cohen Sarah; Adelsperger Jennifer; Okabe Rachel; Coburn Allison; Moore Sandra; Huntly Brian J P; Fabbro Doriano; Anderson Kenneth C; Griffin James D; Gilliland Dwight Gary
FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignancies.
Oncogene 2005;24(56):8259-67.
2005: Lee Benjamin H; Williams Ifor R; Anastasiadou Ema; Boulton Christina L; Joseph Sarah W; Amaral Sonia M; Curley David P; Duclos Nicole; Huntly Brian J P; Fabbro Doriano; Griffin James D; Gilliland Dwight Gary
FLT3 internal tandem duplication mutations induce myeloproliferative or lymphoid disease in a transgenic mouse model.
Oncogene 2005;24(53):7882-92.
2005: Levine Ross L; Loriaux Marc; Huntly Brian J P; Loh Mignon L; Beran Miroslav; Stoffregen Eric; Berger Roland; Clark Jennifer J; Willis Stephanie G; Nguyen Kim T; Flores Nikki J; Estey Elihu; Gattermann Norbert; Armstrong Scott; Look A Thomas; Griffin James D; Bernard Olivier A; Heinrich Michael C; Gilliland D Gary; Druker Brian; Deininger Michael W N
The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia.
Blood 2005;106(10):3377-9.
2005: Stover Elizabeth H; Chen Jing; Lee Benjamin H; Cools Jan; McDowell Elizabeth; Adelsperger Jennifer; Cullen Dana; Coburn Allison; Moore Sandra A; Okabe Rachel; Fabbro Doriano; Manley Paul W; Griffin James D; Gilliland D Gary
The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in vitro and in vivo.
Blood 2005;106(9):3206-13.
2005: Jiang Jingrui; Greulich Heidi; Jänne Pasi A; Sellers William R; Meyerson Matthew; Griffin James D
Epidermal growth factor-independent transformation of Ba/F3 cells with cancer-derived epidermal growth factor receptor mutants induces gefitinib-sensitive cell cycle progression.
Cancer research 2005;65(19):8968-74.
2005: Golemovic Mirna; Verstovsek Srdan; Giles Francis; Cortes Jorge; Manshouri Taghi; Manley Paul W; Mestan Jürgen; Dugan Margaret; Alland Leila; Griffin James D; Arlinghaus Ralph B; Sun Tong; Kantarjian Hagop; Beran Miloslav
AMN107, a novel aminopyrimidine inhibitor of Bcr-Abl, has in vitro activity against imatinib-resistant chronic myeloid leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(13):4941-7.
2005: Wu Lizi; Liu Jingxuan; Gao Ping; Nakamura Makoto; Cao Yang; Shen Huangxuan; Griffin James D
Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation.
The EMBO journal 2005;24(13):2391-402.
2005: Growney Joseph D; Clark Jennifer J; Adelsperger Jennifer; Stone Richard; Fabbro Doriano; Griffin James D; Gilliland D Gary
Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412.
Blood 2005;106(2):721-4.
2005: Mayerhofer Matthias; Aichberger Karl J; Florian Stefan; Krauth Maria-Theresa; Hauswirth Alexander W; Derdak Sophia; Sperr Wolfgang R; Esterbauer Harald; Wagner Oswald; Marosi Christine; Pickl Winfried F; Deininger Michael; Weisberg Ellen; Druker Brian J; Griffin James D; Sillaber Christian; Valent Peter
Identification of mTOR as a novel bifunctional target in chronic myeloid leukemia: dissection of growth-inhibitory and VEGF-suppressive effects of rapamycin in leukemic cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(8):960-2.
2005: Levine Ross L; Wadleigh Martha; Cools Jan; Ebert Benjamin L; Wernig Gerlinde; Huntly Brian J P; Boggon Titus J; Wlodarska Iwona; Clark Jennifer J; Moore Sandra; Adelsperger Jennifer; Koo Sumin; Lee Jeffrey C; Gabriel Stacey; Mercher Thomas; D'Andrea Alan; Fröhling Stefan; Döhner Konstanze; Marynen Peter; Vandenberghe Peter; Mesa Ruben A; Tefferi Ayalew; Griffin James D; Eck Michael J; Sellers William R; Meyerson Matthew; Golub Todd R; Lee Stephanie J; Gilliland D Gary
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.
Cancer cell 2005;7(4):387-97.
2005: Okuda K; Oda A; Sato Y; Nakayama A; Fujita H; Sonoda Y; Griffin J D
Signal transduction and cellular functions of the TEL/ARG oncoprotein.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2005;19(4):603-10.
2005: Griffin James D
Interaction maps for kinase inhibitors.
Nature biotechnology 2005;23(3):308-9.
2005: Weisberg Ellen; Manley Paul W; Breitenstein Werner; Brüggen Josef; Cowan-Jacob Sandra W; Ray Arghya; Huntly Brian; Fabbro Doriano; Fendrich Gabriele; Hall-Meyers Elizabeth; Kung Andrew L; Mestan Jürgen; Daley George Q; Callahan Linda; Catley Laurie; Cavazza Cara; Azam Mohammad; Neuberg Donna; Wright Renee D; Gilliland D Gary; Griffin James D
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.
Cancer cell 2005;7(2):129-41.
2005: Kim Jeong H; Chu Stephanie C; Gramlich Jessica L; Pride Yuri B; Babendreier Emily; Chauhan Dharminder; Salgia Ravi; Podar Klaus; Griffin James D; Sattler Martin
Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species.
Blood 2005;105(4):1717-23.
2005: Lin Boris; Catley Laurence; LeBlanc Richard; Mitsiades Constantine; Burger Renate; Tai Yu-Tzu; Podar Klaus; Wartmann Markus; Chauhan Dharminder; Griffin James D; Anderson Kenneth C
Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.
Blood 2005;105(1):350-7.
2005: Wadleigh Martha; DeAngelo Daniel J; Griffin James D; Stone Richard M
After chronic myelogenous leukemia: tyrosine kinase inhibitors in other hematologic malignancies.
Blood 2005;105(1):22-30.
2005: Stone Richard M; DeAngelo Daniel J; Klimek Virginia; Galinsky Ilene; Estey Eli; Nimer Stephen D; Grandin Wilson; Lebwohl David; Wang Yanfeng; Cohen Pamela; Fox Edward A; Neuberg Donna; Clark Jennifer; Gilliland D Gary; Griffin James D
Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412.
Blood 2005;105(1):54-60.
2004: Weisberg E; Catley L; Kujawa J; Atadja P; Remiszewski S; Fuerst P; Cavazza C; Anderson K; Griffin J D
Histone deacetylase inhibitor NVP-LAQ824 has significant activity against myeloid leukemia cells in vitro and in vivo.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2004;18(12):1951-63.
2004: Chen Jing; Deangelo Daniel J; Kutok Jeffery L; Williams Ifor R; Lee Benjamin H; Wadleigh Martha; Duclos Nicole; Cohen Sarah; Adelsperger Jennifer; Okabe Rachel; Coburn Allison; Galinsky Ilene; Huntly Brian; Cohen Pamela S; Meyer Thomas; Fabbro Doriano; Roesel Johannes; Banerji Lolita; Griffin James D; Xiao Sheng; Fletcher Jonathan A; Stone Richard M; Gilliland D Gary
PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(40):14479-84.
2004: Wu Lizi; Griffin James D
Modulation of Notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesis.
Seminars in cancer biology 2004;14(5):348-56.
2004: Cools Jan; Mentens Nicole; Furet Pascal; Fabbro Doriano; Clark Jennifer J; Griffin James D; Marynen Peter; Gilliland D Gary
Prediction of resistance to small molecule FLT3 inhibitors: implications for molecularly targeted therapy of acute leukemia.
Cancer research 2004;64(18):6385-9.
2004: Jiang Jingrui; Paez J Guillermo; Lee Jeffrey C; Bo Ronghai; Stone Richard M; DeAngelo Daniel J; Galinsky Ilene; Wolpin Brian M; Jonasova Anna; Herman Paula; Fox Edward A; Boggon Titus J; Eck Michael J; Weisberg Ellen; Griffin James D; Gilliland D Gary; Meyerson Matthew; Sellers William R
Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML.
Blood 2004;104(6):1855-8.
2004: Chen Jing; Wall Nathan R; Kocher Kerry; Duclos Nicole; Fabbro Doriano; Neuberg Donna; Griffin James D; Shi Yang; Gilliland D Gary
Stable expression of small interfering RNA sensitizes TEL-PDGFbetaR to inhibition with imatinib or rapamycin.
The Journal of clinical investigation 2004;113(12):1784-91.
2004: Gu Ting-Lei; Tothova Zuzana; Scheijen Blanca; Griffin James D; Gilliland D Gary; Sternberg David W
NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a.
Blood 2004;103(12):4622-9.
2004: Scheijen Blanca; Ngo Hai T; Kang Hyun; Griffin James D
FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins.
Oncogene 2004;23(19):3338-49.
2004: Cools Jan; Quentmeier Hilmar; Huntly Brian J P; Marynen Peter; Griffin James D; Drexler Hans G; Gilliland D Gary
The EOL-1 cell line as an in vitro model for the study of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia.
Blood 2004;103(7):2802-5.
2004: Cowan-Jacob Sandra W; Guez Valerie; Fendrich Gabriele; Griffin James D; Fabbro Doriano; Furet Pascal; Liebetanz Janis; Mestan Jürgen; Manley Paul W
Imatinib (STI571) resistance in chronic myelogenous leukemia: molecular basis of the underlying mechanisms and potential strategies for treatment.
Mini reviews in medicinal chemistry 2004;4(3):285-99.
2004: Wu Lizi; Kobayashi Karla; Sun Tao; Gao Ping; Liu Jingxuan; Nakamura Makoto; Weisberg Ellen; Mukhopadhyay Nishit K; Griffin James D
Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene.
Gene 2004;328():153-65.
2004: Mohi M Golam; Boulton Christina; Gu Ting-Lei; Sternberg David W; Neuberg Donna; Griffin James D; Gilliland D Gary; Neel Benjamin G
Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3130-5.
2004: Okuda Keiko; Sato Yuko; Sonoda Yoshiaki; Griffin James D
The TEL/ARG leukemia oncogene promotes viability and hyperresponsiveness to hematopoietic growth factors.
International journal of hematology 2004;79(2):138-46.
2004: Griffin James D
FLT3 tyrosine kinase as a target in acute leukemias.
The hematology journal : the official journal of the European Haematology Association / EHA 2004;5 Suppl 3():S188-90.
2004: Stone R M; De Angelo J; Galinsky I; Estey E; Klimek V; Grandin W; Lebwohl D; Yap A; Cohen P; Fox E; Neuberg D; Clark J; Gilliland D G; Griffin J D
PKC 412 FLT3 inhibitor therapy in AML: results of a phase II trial.
Annals of hematology 2004;83 Suppl 1():S89-90.
2003: Sawafuji Kanoko; Miyakawa Yoshitaka; Weisberg Ellen; Griffin James D; Ikeda Yasuo; Kizaki Masahiro
Aminopeptidase inhibitors inhibit proliferation and induce apoptosis of K562 and STI571-resistant K562 cell lines through the MAPK and GSK-3beta pathways.
Leukemia & lymphoma 2003;44(11):1987-96.
2003: Weisberg Ellen; Griffin James D
Resistance to imatinib (Glivec): update on clinical mechanisms.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2003;6(5):231-8.
2003: Ma Patrick C; Kijima Takashi; Maulik Gautam; Fox Edward A; Sattler Martin; Griffin James D; Johnson Bruce E; Salgia Ravi
c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions.
Cancer research 2003;63(19):6272-81.
2003: Cools Jan; Stover Elizabeth H; Boulton Christina L; Gotlib Jason; Legare Robert D; Amaral Sonia M; Curley David P; Duclos Nicole; Rowan Rebecca; Kutok Jeffery L; Lee Benjamin H; Williams Ifor R; Coutre Steven E; Stone Richard M; DeAngelo Daniel J; Marynen Peter; Manley Paul W; Meyer Thomas; Fabbro Doriano; Neuberg Donna; Weisberg Ellen; Griffin James D; Gilliland D Gary
PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRalpha-induced myeloproliferative disease.
Cancer cell 2003;3(5):459-69.
2003: Sattler Martin; Griffin James D
Molecular mechanisms of transformation by the BCR-ABL oncogene.
Seminars in hematology 2003;40(2 Suppl 2):4-10.
2003: Cools Jan; DeAngelo Daniel J; Gotlib Jason; Stover Elizabeth H; Legare Robert D; Cortes Jorges; Kutok Jeffrey; Clark Jennifer; Galinsky Ilene; Griffin James D; Cross Nicholas C P; Tefferi Ayalew; Malone James; Alam Rafeul; Schrier Stanley L; Schmid Janet; Rose Michal; Vandenberghe Peter; Verhoef Gregor; Boogaerts Marc; Wlodarska Iwona; Kantarjian Hagop; Marynen Peter; Coutre Steven E; Stone Richard; Gilliland D Gary
A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome.
The New England journal of medicine 2003;348(13):1201-14.
2003: Armstrong Scott A; Kung Andrew L; Mabon Meghann E; Silverman Lewis B; Stam Ronald W; Den Boer Monique L; Pieters Rob; Kersey John H; Sallan Stephen E; Fletcher Jonathan A; Golub Todd R; Griffin James D; Korsmeyer Stanley J
Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification.
Cancer cell 2003;3(2):173-83.
2003: Tonon Giovanni; Modi Sanjay; Wu Lizi; Kubo Akihito; Coxon Amy B; Komiya Takefumi; O'Neil Kevin; Stover Kristen; El-Naggar Adel; Griffin James D; Kirsch Ilan R; Kaye Frederic J
t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway.
Nature genetics 2003;33(2):208-13.
2003: Weng Andrew P; Nam Yunsun; Wolfe Michael S; Pear Warren S; Griffin James D; Blacklow Stephen C; Aster Jon C
Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.
Molecular and cellular biology 2003;23(2):655-64.
2003: Löwenberg Bob; Griffin James D; Tallman Martin S
Acute myeloid leukemia and acute promyelocytic leukemia.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2003;():82-101.
2003: Sattler Martin; Scheijen Blanca; Weisberg Ellen; Griffin James D
Mutated tyrosine kinases as therapeutic targets in myeloid leukemias.
Advances in experimental medicine and biology 2003;532():121-40.
2002: Mayerhofer Matthias; Valent Peter; Sperr Wolfgang R; Griffin James D; Sillaber Christian
BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin.
Blood 2002;100(10):3767-75.
2002: Wu Lizi; Sun Tao; Kobayashi Karla; Gao Ping; Griffin James D
Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.
Molecular and cellular biology 2002;22(21):7688-700.
2002: Lin Boris; Podar Klaus; Gupta Deepak; Tai Yu-Tzu; Li Sigui; Weller Edie; Hideshima Teru; Lentzsch Suzanne; Davies Faith; Li Cheng; Weisberg Ellen; Schlossman Robert L; Richardson Paul G; Griffin James D; Wood Jeanette; Munshi Nikhil C; Anderson Kenneth C
The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment.
Cancer research 2002;62(17):5019-26.
2002: Gilliland D Gary; Griffin James D
The roles of FLT3 in hematopoiesis and leukemia.
Blood 2002;100(5):1532-42.
2002: Gilliland D Gary; Griffin James D
Role of FLT3 in leukemia.
Current opinion in hematology 2002;9(4):274-81.
2002: Sattler Martin; Mohi M Golam; Pride Yuri B; Quinnan Laura R; Malouf Nicole A; Podar Klaus; Gesbert Franck; Iwasaki Hiromi; Li Shaoguang; Van Etten Richard A; Gu Haihua; Griffin James D; Neel Benjamin G
Critical role for Gab2 in transformation by BCR/ABL.
Cancer cell 2002;1(5):479-92.
2002: Weisberg Ellen; Boulton Christina; Kelly Louise M; Manley Paul; Fabbro Doriano; Meyer Thomas; Gilliland D Gary; Griffin James D
Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412.
Cancer cell 2002;1(5):433-43.
2002: Liu Shouchun; Kiosses William B; Rose David M; Slepak Marina; Salgia Ravi; Griffin James D; Turner Christopher E; Schwartz Martin A; Ginsberg Mark H
A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration.
The Journal of biological chemistry 2002;277(23):20887-94.
2002: Scheijen Blanca; Griffin James D
Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease.
Oncogene 2002;21(21):3314-33.
2002: Lu Q; Mukhopadhyay N K; Griffin J D; Paredes M; Medina M; Kosik K S
Brain armadillo protein delta-catenin interacts with Abl tyrosine kinase and modulates cellular morphogenesis in response to growth factors.
Journal of neuroscience research 2002;67(5):618-24.
2002: Sattler Martin; Pride Yuri B; Quinnan Laura R; Verma Shalini; Malouf Nicole A; Husson Hervé; Salgia Ravi; Lipkowitz Stanley; Griffin James D
Differential expression and signaling of CBL and CBL-B in BCR/ABL transformed cells.
Oncogene 2002;21(9):1423-33.
2002: Griffin James D
Resistance to targeted therapy in leukaemia.
Lancet 2002;359(9305):458-9.
2002: Mow Benjamin M F; Chandra Joya; Svingen Phyllis A; Hallgren Christopher G; Weisberg Ellen; Kottke Timothy J; Narayanan Ven L; Litzow Mark R; Griffin James D; Sausville Edward A; Tefferi Ayalew; Kaufmann Scott H
Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro.
Blood 2002;99(2):664-71.
2001: Griffin J D
Leukemia stem cells and constitutive activation of NF-kappaB.
Blood 2001;98(8):2291.
2001: Kojika S; Griffin J D
Notch receptors and hematopoiesis.
Experimental hematology 2001;29(9):1041-52.
2001: Bruecher-Encke B; Griffin J D; Neel B G; Lorenz U
Role of the tyrosine phosphatase SHP-1 in K562 cell differentiation.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2001;15(9):1424-32.
2001: Griffin J D
Phosphatidyl inositol signaling by BCR/ABL: opportunities for drug development.
Cancer chemotherapy and pharmacology 2001;48 Suppl 1():S11-6.
2001: Tuveson D A; Willis N A; Jacks T; Griffin J D; Singer S; Fletcher C D; Fletcher J A; Demetri G D
STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications.
Oncogene 2001;20(36):5054-8.
2001: Griffin J D
Investigator profile: James D. Griffin M.D. interviewed by Vicki P. Glaser.
Journal of hematotherapy & stem cell research 2001;10(2):209-14.
2001: Sattler M; Griffin J D
Mechanisms of transformation by the BCR/ABL oncogene.
International journal of hematology 2001;73(3):278-91.
2001: Okuda K; Weisberg E; Gilliland D G; Griffin J D
ARG tyrosine kinase activity is inhibited by STI571.
Blood 2001;97(8):2440-8.
2001: Griffin J D
Point mutations in the FLT3 gene in AML.
Blood 2001;97(8):2193A-2193.
2001: Weisberg E; Griffin J D
Mechanisms of resistance imatinib (STI571) in preclinical models and in leukemia patients.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2001;4(1):22-8.
2001: Sattler M; Verma S; Pride Y B; Salgia R; Rohrschneider L R; Griffin J D
SHIP1, an SH2 domain containing polyinositol-5-phosphatase, regulates migration through two critical tyrosine residues and forms a novel signaling complex with DOK1 and CRKL.
The Journal of biological chemistry 2001;276(4):2451-8.
2000: Wu L; Aster J C; Blacklow S C; Lake R; Artavanis-Tsakonas S; Griffin J D
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.
Nature genetics 2000;26(4):484-9.
2000: Gesbert F; Sellers W R; Signoretti S; Loda M; Griffin J D
BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-Kinase/AKT pathway.
The Journal of biological chemistry 2000;275(50):39223-30.
2000: Uemura N; Griffin J D
The ABL kinase inhibitor STI571 does not affect survival of hematopoietic cells after ionizing radiation.
Blood 2000;96(9):3294-5.
2000: Gesbert F; Griffin J D
Bcr/Abl activates transcription of the Bcl-X gene through STAT5.
Blood 2000;96(6):2269-76.
2000: Sattler M; Verma S; Shrikhande G; Byrne C H; Pride Y B; Winkler T; Greenfield E A; Salgia R; Griffin J D
The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells.
The Journal of biological chemistry 2000;275(32):24273-8.
2000: Wang W L; Healy M E; Sattler M; Verma S; Lin J; Maulik G; Stiles C D; Griffin J D; Johnson B E; Salgia R
Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571.
Oncogene 2000;19(31):3521-8.
2000: Weisberg E; Griffin J D
Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines.
Blood 2000;95(11):3498-505.
2000: Sillaber C; Gesbert F; Frank D A; Sattler M; Griffin J D
STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells.
Blood 2000;95(6):2118-25.
2000: Ichinohasama R; Miura I; Takahashi N; Sugawara T; Tamate E; Endoh K; Endoh F; Naganuma H; DeCoteau J F; Griffin J D; Kadin M E; Ooya K
Ph-negative non-Hodgkin's lymphoma occurring in chronic phase of Ph-positive chronic myelogenous leukemia is defined as a genetically different neoplasm from extramedullary localized blast crisis: report of two cases and review of the literature.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2000;14(1):169-82.
2000: Shen Y; Lyons P; Cooley M; Davidson D; Veillette A; Salgia R; Griffin J D; Schaller M D
The noncatalytic domain of protein-tyrosine phosphatase-PEST targets paxillin for dephosphorylation in vivo.
The Journal of biological chemistry 2000;275(2):1405-13.
1999: Uemura N; Griffin J D
The adapter protein Crkl links Cbl to C3G after integrin ligation and enhances cell migration.
The Journal of biological chemistry 1999;274(53):37525-32.
1999: Thomas J W; Cooley M A; Broome J M; Salgia R; Griffin J D; Lombardo C R; Schaller M D
The role of focal adhesion kinase binding in the regulation of tyrosine phosphorylation of paxillin.
The Journal of biological chemistry 1999;274(51):36684-92.
1999: Salgia R; Quackenbush E; Lin J; Souchkova N; Sattler M; Ewaniuk D S; Klucher K M; Daley G Q; Kraeft S K; Sackstein R; Alyea E P; von Andrian U H; Chen L B; Gutierrez-Ramos J C; Pendergast A M; Griffin J D
The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1alpha.
Blood 1999;94(12):4233-46.
1999: Sun Y; Zhang J; Kraeft S K; Auclair D; Chang M S; Liu Y; Sutherland R; Salgia R; Griffin J D; Ferland L H; Chen L B
Molecular cloning and characterization of human trabeculin-alpha, a giant protein defining a new family of actin-binding proteins.
The Journal of biological chemistry 1999;274(47):33522-30.
1999: Sattler M; Verma S; Byrne C H; Shrikhande G; Winkler T; Algate P A; Rohrschneider L R; Griffin J D
BCR/ABL directly inhibits expression of SHIP, an SH2-containing polyinositol-5-phosphatase involved in the regulation of hematopoiesis.
Molecular and cellular biology 1999;19(11):7473-80.
1999: Vallera D A; Seo S Y; Panoskaltsis-Mortari A; Griffin J D; Blazar B R
Targeting myeloid leukemia with a DT(390)-mIL-3 fusion immunotoxin: ex vivo and in vivo studies in mice.
Protein engineering 1999;12(9):779-85.
1999: Uemura N; Salgia R; Ewaniuk D S; Little M T; Griffin J D
Involvement of the adapter protein CRKL in integrin-mediated adhesion.
Oncogene 1999;18(22):3343-53.
1999: Sattler M; Winkler T; Verma S; Byrne C H; Shrikhande G; Salgia R; Griffin J D
Hematopoietic growth factors signal through the formation of reactive oxygen species.
Blood 1999;93(9):2928-35.
1999: Okuda K; Foster R; Griffin J D
Signaling domains of the beta c chain of the GM-CSF/IL-3/IL-5 receptor.
Annals of the New York Academy of Sciences 1999;872():305-12; discussion 312-3.
1999: Salgia R; Li J L; Ewaniuk D S; Wang Y B; Sattler M; Chen W C; Richards W; Pisick E; Shapiro G I; Rollins B J; Chen L B; Griffin J D; Sugarbaker D J
Expression of the focal adhesion protein paxillin in lung cancer and its relation to cell motility.
Oncogene 1999;18(1):67-77.
1998: Reed M F; Liu V F; Ladha M H; Ando K; Griffin J D; Weaver D T; Ewen M E
Enforced CDK4 expression in a hematopoietic cell line confers resistance to the G1 arrest induced by ionizing radiation.
Oncogene 1998;17(23):2961-71.
1998: Okuda K; D'Andrea A; Van Etten R A; Griffin J D
The C-terminus of c-ABL is required for proliferation and viability signaling in a c-ABL/erythropoietin receptor fusion protein.
Blood 1998;92(10):3848-56.
1997: Tong X; Salgia R; Li J L; Griffin J D; Howley P M
The bovine papillomavirus E6 protein binds to the LD motif repeats of paxillin and blocks its interaction with vinculin and the focal adhesion kinase.
The Journal of biological chemistry 1997;272(52):33373-6.
1997: Hallek M; Neumann C; Schäffer M; Danhauser-Riedl S; von Bubnoff N; de Vos G; Druker B J; Yasukawa K; Griffin J D; Emmerich B
Signal transduction of interleukin-6 involves tyrosine phosphorylation of multiple cytosolic proteins and activation of Src-family kinases Fyn, Hck, and Lyn in multiple myeloma cell lines.
Experimental hematology 1997;25(13):1367-77.
1997: Okuda K; Smith L; Griffin J D; Foster R
Signaling functions of the tyrosine residues in the betac chain of the granulocyte-macrophage colony-stimulating factor receptor.
Blood 1997;90(12):4759-66.
1997: Zhao R C; McIvor R S; Griffin J D; Verfaillie C M
Gene therapy for chronic myelogenous leukemia (CML): a retroviral vector that renders hematopoietic progenitors methotrexate-resistant and CML progenitors functionally normal and nontumorigenic in vivo.
Blood 1997;90(12):4687-98.
1997: Sattler M; Salgia R; Shrikhande G; Verma S; Choi J L; Rohrschneider L R; Griffin J D
The phosphatidylinositol polyphosphate 5-phosphatase SHIP and the protein tyrosine phosphatase SHP-2 form a complex in hematopoietic cells which can be regulated by BCR/ABL and growth factors.
Oncogene 1997;15(19):2379-84.
1997: Okuda K; D'Andrea A; Etten R A; Griffin J D
A chimeric receptor/oncogene that can be regulated by a ligand in vitro and in vivo.
The Journal of clinical investigation 1997;100(7):1708-15.
1997: Salgia R; Li J L; Ewaniuk D S; Pear W; Pisick E; Burky S A; Ernst T; Sattler M; Chen L B; Griffin J D
BCR/ABL induces multiple abnormalities of cytoskeletal function.
The Journal of clinical investigation 1997;100(1):46-57.
1997: Gu H; Griffin J D; Neel B G
Characterization of two SHP-2-associated binding proteins and potential substrates in hematopoietic cells.
The Journal of biological chemistry 1997;272(26):16421-30.
1997: Sattler M; Salgia R; Shrikhande G; Verma S; Uemura N; Law S F; Golemis E A; Griffin J D
Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1).
The Journal of biological chemistry 1997;272(22):14320-6.
1997: Sattler M; Salgia R; Durstin M A; Prasad K V; Griffin J D
Thrombopoietin induces activation of the phosphatidylinositol-3' kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL.
Journal of cellular physiology 1997;171(1):28-33.
1997: Sattler M; Salgia R; Shrikhande G; Verma S; Pisick E; Prasad K V; Griffin J D
Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL).
The Journal of biological chemistry 1997;272(15):10248-53.
1997: Uemura N; Salgia R; Li J L; Pisick E; Sattler M; Griffin J D
The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(3):376-85.
1997: Manié S N; Beck A R; Astier A; Law S F; Canty T; Hirai H; Druker B J; Avraham H; Haghayeghi N; Sattler M; Salgia R; Griffin J D; Golemis E A; Freedman A S
Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells.
The Journal of biological chemistry 1997;272(7):4230-6.
1997: Manié S N; Sattler M; Astier A; Phifer J S; Canty T; Morimoto C; Druker B J; Salgia R; Griffin J D; Freedman A S
Tyrosine phosphorylation of the product of the c-cbl protooncogene is [corrected] induced after integrin stimulation.
Experimental hematology 1997;25(1):45-50.
1996: Salgia R; Avraham S; Pisick E; Li J L; Raja S; Greenfield E A; Sattler M; Avraham H; Griffin J D
The related adhesion focal tyrosine kinase forms a complex with paxillin in hematopoietic cells.
The Journal of biological chemistry 1996;271(49):31222-6.
1996: Xia K; Mukhopadhyay N K; Inhorn R C; Barber D L; Rose P E; Lee R S; Narsimhan R P; D'Andrea A D; Griffin J D; Roberts T M
The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11681-6.
1996: Scammell T E; Elmquist J K; Griffin J D; Saper C B
Ventromedial preoptic prostaglandin E2 activates fever-producing autonomic pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(19):6246-54.
1996: Salgia R; Pisick E; Sattler M; Li J L; Uemura N; Wong W K; Burky S A; Hirai H; Chen L B; Griffin J D
p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene.
The Journal of biological chemistry 1996;271(41):25198-203.
1996: Okuda K; Golub T R; Gilliland D G; Griffin J D
p210BCR/ABL, p190BCR/ABL, and TEL/ABL activate similar signal transduction pathways in hematopoietic cell lines.
Oncogene 1996;13(6):1147-52.
1996: Hallek M; Danhauser-Riedl S; Herbst R; Warmuth M; Winkler A; Kolb H J; Druker B; Griffin J D; Emmerich B; Ullrich A
Interaction of the receptor tyrosine kinase p145c-kit with the p210bcr/abl kinase in myeloid cells.
British journal of haematology 1996;94(1):5-16.
1996: Bazzoni G; Carlesso N; Griffin J D; Hemler M E
Bcr/Abl expression stimulates integrin function in hematopoietic cell lines.
The Journal of clinical investigation 1996;98(2):521-8.
1996: Durstin M; Inhorn R C; Griffin J D
Tyrosine phosphorylation of Shc is not required for proliferation or viability signaling by granulocyte-macrophage colony-stimulating factor in hematopoietic cell lines.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(2):534-40.
1996: Carlesso N; Frank D A; Griffin J D
Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.
The Journal of experimental medicine 1996;183(3):811-20.
1996: Salgia R; Sattler M; Pisick E; Li J L; Griffin J D
p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl.
Experimental hematology 1996;24(2):310-3.
1996: Sattler M; Salgia R; Okuda K; Uemura N; Durstin M A; Pisick E; Xu G; Li J L; Prasad K V; Griffin J D
The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3' kinase pathway.
Oncogene 1996;12(4):839-46.
1996: Matulonis U; Dosiou C; Freeman G; Lamont C; Mauch P; Nadler L M; Griffin J D
B7-1 is superior to B7-2 costimulation in the induction and maintenance of T cell-mediated antileukemia immunity. Further evidence that B7-1 and B7-2 are functionally distinct.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(3):1126-31.
1995: Inhorn R C; Carlesso N; Durstin M; Frank D A; Griffin J D
Identification of a viability domain in the granulocyte/macrophage colony-stimulating factor receptor beta-chain involving tyrosine-750.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(19):8665-9.
1995: Salgia R; Brunkhorst B; Pisick E; Li J L; Lo S H; Chen L B; Griffin J D
Increased tyrosine phosphorylation of focal adhesion proteins in myeloid cell lines expressing p210BCR/ABL.
Oncogene 1995;11(6):1149-55.
1995: Sattler M; Durstin M A; Frank D A; Okuda K; Kaushansky K; Salgia R; Griffin J D
The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases.
Experimental hematology 1995;23(9):1040-8.
1995: Davey F R; Abraham N; Brunetto V L; MacCallum J M; Nelson D A; Ball E D; Griffin J D; Baer M R; Wurster-Hill D; Mayer R J
Morphologic characteristics of erythroleukemia (acute myeloid leukemia; FAB-M6): a CALGB study.
American journal of hematology 1995;49(1):29-38.
1995: Matulonis U A; Dosiou C; Lamont C; Freeman G J; Mauch P; Nadler L M; Griffin J D
Role of B7-1 in mediating an immune response to myeloid leukemia cells.
Blood 1995;85(9):2507-15.
1995: Drachman J G; Griffin J D; Kaushansky K
The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl.
The Journal of biological chemistry 1995;270(10):4979-82.
1995: Oda T; Tamura S; Matsuguchi T; Griffin J D; Druker B J
The SH2 domain of ABL is not required for factor-independent growth induced by BCR-ABL in a murine myeloid cell line.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9(2):295-301.
1995: Ando K; Griffin J D
Cdk4 integrates growth stimulatory and inhibitory signals during G1 phase of hematopoietic cells.
Oncogene 1995;10(4):751-5.
1995: Matsuguchi T; Inhorn R C; Carlesso N; Xu G; Druker B; Griffin J D
Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL.
The EMBO journal 1995;14(2):257-65.
1994: Eder M; Ernst T J; Ganser A; Jubinsky P T; Inhorn R; Hoelzer D; Griffin J D
A low affinity chimeric human alpha/beta-granulocyte-macrophage colony-stimulating factor receptor induces ligand-dependent proliferation in a murine cell line.
The Journal of biological chemistry 1994;269(48):30173-80.
1994: Boussiotis V A; Freeman G J; Griffin J D; Gray G S; Gribben J G; Nadler L M
CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy.
The Journal of experimental medicine 1994;180(5):1665-73.
1994: Okuda K; Matulonis U; Salgia R; Kanakura Y; Druker B; Griffin J D
Factor independence of human myeloid leukemia cell lines is associated with increased phosphorylation of the proto-oncogene Raf-1.
Experimental hematology 1994;22(11):1111-7.
1994: Okuda K; Ernst T J; Griffin J D
Inhibition of p21ras activation blocks proliferation but not differentiation of interleukin-3-dependent myeloid cells.
The Journal of biological chemistry 1994;269(40):24602-7.
1994: Oda T; Heaney C; Hagopian J R; Okuda K; Griffin J D; Druker B J
Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia.
The Journal of biological chemistry 1994;269(37):22925-8.
1994: Avalos B R; Broudy V C; Ceselski S K; Druker B J; Griffin J D; Hammond W P
Abnormal response to granulocyte colony-stimulating factor (G-CSF) in canine cyclic hematopoiesis is not caused by altered G-CSF receptor expression.
Blood 1994;84(3):789-94.
1994: Quelle F W; Sato N; Witthuhn B A; Inhorn R C; Eder M; Miyajima A; Griffin J D; Ihle J N
JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region.
Molecular and cellular biology 1994;14(7):4335-41.
1994: Hallek M; Ando K; Eder M; Slattery K; Ajchenbaum-Cymbalista F; Griffin J D
Signal transduction of steel factor and granulocyte-macrophage colony-stimulating factor: differential regulation of transcription factor and G1 cyclin gene expression, and of proliferation in the human factor-dependent cell line MO7.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1994;8(5):740-8.
1994: Matulonis U A; Griffin J D; Canellos G P
Autologous peripheral stem cell transplantation of the blastic phase of chronic myeloid leukemia following sequential high-dose cytosine arabinoside and melphalan.
American journal of hematology 1994;45(4):283-7.
1994: Ernst T J; Slattery K E; Griffin J D
p210Bcr/Abl and p160v-Abl induce an increase in the tyrosine phosphorylation of p93c-Fes.
The Journal of biological chemistry 1994;269(8):5764-9.
1994: Torisky R S; Griffin J D; Yenofsky R L; Polacco J C
A single gene (Eu4) encodes the tissue-ubiquitous urease of soybean.
Molecular & general genetics : MGG 1994;242(4):404-14.
1994: Druker B J; Neumann M; Okuda K; Franza B R; Griffin J D
rel Is rapidly tyrosine-phosphorylated following granulocyte-colony stimulating factor treatment of human neutrophils.
The Journal of biological chemistry 1994;269(7):5387-90.
1994: Matsuguchi T; Salgia R; Hallek M; Eder M; Druker B; Ernst T J; Griffin J D
Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony-stimulating factor, interleukin-3, and steel factor and is constitutively increased by p210BCR/ABL.
The Journal of biological chemistry 1994;269(7):5016-21.
1994: Carlesso N; Griffin J D; Druker B J
Use of a temperature-sensitive mutant to define the biological effects of the p210BCR-ABL tyrosine kinase on proliferation of a factor-dependent murine myeloid cell line.
Oncogene 1994;9(1):149-56.
1993: Ando K; Ajchenbaum-Cymbalista F; Griffin J D
Regulation of G1/S transition by cyclins D2 and D3 in hematopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(20):9571-5.
1993: Matulonis U; Salgia R; Okuda K; Druker B; Griffin J D
Interleukin-3 and p210 BCR/ABL activate both unique and overlapping pathways of signal transduction in a factor-dependent myeloid cell line.
Experimental hematology 1993;21(11):1460-6.
1993: Robertson M J; Tantravahi R; Griffin J D; Canellos G P; Cannistra S A
Hematologic remission and cytogenetic improvement after treatment of stable-phase chronic myelogenous leukemia with continuous infusion of low-dose cytarabine.
American journal of hematology 1993;43(2):95-102.
1993: Stone R M; Spriggs D R; Arthur K A; Mayer R J; Griffin J; Kufe D W
Recombinant human gamma interferon administered by continuous intravenous infusion in acute myelogenous leukemia and myelodysplastic syndromes.
American journal of clinical oncology 1993;16(2):159-63.
1993: Eder M; Griffin J D; Ernst T J
The human granulocyte-macrophage colony-stimulating factor receptor is capable of initiating signal transduction in NIH3T3 cells.
The EMBO journal 1993;12(4):1647-56.
1993: Ajchenbaum F; Ando K; DeCaprio J A; Griffin J D
Independent regulation of human D-type cyclin gene expression during G1 phase in primary human T lymphocytes.
The Journal of biological chemistry 1993;268(6):4113-9.
1992: Hallek M; Lepisto E M; Slattery K E; Griffin J D; Ernst T J
Interferon-gamma increases the expression of the gene encoding the beta subunit of the granulocyte-macrophage colony-stimulating factor receptor.
Blood 1992;80(7):1736-42.
1992: Hallek M; Druker B; Lepisto E M; Wood K W; Ernst T J; Griffin J D
Granulocyte-macrophage colony-stimulating factor and steel factor induce phosphorylation of both unique and overlapping signal transduction intermediates in a human factor-dependent hematopoietic cell line.
Journal of cellular physiology 1992;153(1):176-86.
1992: Petros W P; Rabinowitz J; Stuart A R; Gilbert C J; Kanakura Y; Griffin J D; Peters W P
Disposition of recombinant human granulocyte-macrophage colony-stimulating factor in patients receiving high-dose chemotherapy and autologous bone marrow support.
Blood 1992;80(5):1135-40.
1992: Furukawa Y; Uenoyama S; Ohta M; Tsunoda A; Griffin J D; Saito M
Transforming growth factor-beta inhibits phosphorylation of the retinoblastoma susceptibility gene product in human monocytic leukemia cell line JOSK-I.
The Journal of biological chemistry 1992;267(24):17121-7.
1992: Gribben J G; Saporito L; Barber M; Blake K W; Edwards R M; Griffin J D; Freedman A S; Nadler L M
Bone marrows of non-Hodgkin's lymphoma patients with a bcl-2 translocation can be purged of polymerase chain reaction-detectable lymphoma cells using monoclonal antibodies and immunomagnetic bead depletion.
Blood 1992;80(4):1083-9.
1992: Okuda K; Sanghera J S; Pelech S L; Kanakura Y; Hallek M; Griffin J D; Druker B J
Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase.
Blood 1992;79(11):2880-7.
1992: Robertson M J; Soiffer R J; Freedman A S; Rabinowe S L; Anderson K C; Ervin T J; Murray C; Dear K; Griffin J D; Nadler L M
Human bone marrow depleted of CD33-positive cells mediates delayed but durable reconstitution of hematopoiesis: clinical trial of MY9 monoclonal antibody-purged autografts for the treatment of acute myeloid leukemia.
Blood 1992;79(9):2229-36.
1992: Druker B; Okuda K; Matulonis U; Salgia R; Roberts T; Griffin J D
Tyrosine phosphorylation of rasGAP and associated proteins in chronic myelogenous leukemia cell lines.
Blood 1992;79(9):2215-20.
1992: La Russa V F; Griffin J D; Kessler S W; Cutting M A; Knight R D; Blattler W A; Lambert J M; Wright D G
Effects of anti-CD33 blocked ricin immunotoxin on the capacity of CD34+ human marrow cells to establish in vitro hematopoiesis in long-term marrow cultures.
Experimental hematology 1992;20(4):442-8.
1992: DeCaprio J A; Furukawa Y; Ajchenbaum F; Griffin J D; Livingston D M
The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(5):1795-8.
1992: Ishida Y; Furukawa Y; Decaprio J A; Saito M; Griffin J D
Treatment of myeloid leukemic cells with the phosphatase inhibitor okadaic acid induces cell cycle arrest at either G1/S or G2/M depending on dose.
Journal of cellular physiology 1992;150(3):484-92.
1992: Tamaki T; Kanakura Y; Kuriu A; Ikeda H; Mitsui H; Yagura H; Matsumura I; Druker B; Griffin J D; Kanayama Y
Surface immunoglobulin-mediated signal transduction involves rapid phosphorylation and activation of the protooncogene product Raf-1 in human B-cells.
Cancer research 1992;52(3):566-70.
1992: Koenigsmann M; Griffin J D; DiCarlo J; Cannistra S A
Myeloid and erythroid progenitor cells from normal bone marrow adhere to collagen type I.
Blood 1992;79(3):657-65.
1991: Ikeda H; Kanakura Y; Tamaki T; Kuriu A; Kitayama H; Ishikawa J; Kanayama Y; Yonezawa T; Tarui S; Griffin J D
Expression and functional role of the proto-oncogene c-kit in acute myeloblastic leukemia cells.
Blood 1991;78(11):2962-8.
1991: Kuriu A; Ikeda H; Kanakura Y; Griffin J D; Druker B; Yagura H; Kitayama H; Ishikawa J; Nishiura T; Kanayama Y
Proliferation of human myeloid leukemia cell line associated with the tyrosine-phosphorylation and activation of the proto-oncogene c-kit product.
Blood 1991;78(11):2834-40.
1991: Demetri G D; Griffin J D
Granulocyte colony-stimulating factor and its receptor.
Blood 1991;78(11):2791-808.
1991: Okuda K; Druker B; Kanakura Y; Koenigsmann M; Griffin J D
Internalization of the granulocyte-macrophage colony-stimulating factor receptor is not required for induction of protein tyrosine phosphorylation in human myeloid cells.
Blood 1991;78(8):1928-35.
1991: Spertini O; Luscinskas F W; Kansas G S; Munro J M; Griffin J D; Gimbrone M A; Tedder T F
Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(8):2565-73.
1991: Shipp M A; Stefano G B; Switzer S N; Griffin J D; Reinherz E L
CD10 (CALLA)/neutral endopeptidase 24.11 modulates inflammatory peptide-induced changes in neutrophil morphology, migration, and adhesion proteins and is itself regulated by neutrophil activation.
Blood 1991;78(7):1834-41.
1991: Furukawa Y; DeCaprio J A; Belvin M; Griffin J D
Heterogeneous expression of the product of the retinoblastoma susceptibility gene in primary human leukemia cells.
Oncogene 1991;6(8):1343-6.
1991: Roy D C; Griffin J D; Belvin M; Blättler W A; Lambert J M; Ritz J
Anti-MY9-blocked-ricin: an immunotoxin for selective targeting of acute myeloid leukemia cells.
Blood 1991;77(11):2404-12.
1991: Ball E D; Davis R B; Griffin J D; Mayer R J; Davey F R; Arthur D C; Wurster-Hill D; Noll W; Elghetany M T; Allen S L
Prognostic value of lymphocyte surface markers in acute myeloid leukemia.
Blood 1991;77(10):2242-50.
1991: Spertini O; Freedman A S; Belvin M P; Penta A C; Griffin J D; Tedder T F
Regulation of leukocyte adhesion molecule-1 (TQ1, Leu-8) expression and shedding by normal and malignant cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1991;5(4):300-8.
1991: Cannistra S A; DiCarlo J; Groshek P; Kanakura Y; Berg D; Mayer R J; Griffin J D
Simultaneous administration of granulocyte-macrophage colony-stimulating factor and cytosine arabinoside for the treatment of relapsed acute myeloid leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1991;5(3):230-8.
1991: Kanakura Y; Cannistra S A; Brown C B; Nakamura M; Seelig G F; Prosise W W; Hawkins J C; Kaushansky K; Griffin J D
Identification of functionally distinct domains of human granulocyte-macrophage colony-stimulating factor using monoclonal antibodies.
Blood 1991;77(5):1033-43.
1991: Spertini O; Kansas G S; Munro J M; Griffin J D; Tedder T F
Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin.
Nature 1991;349(6311):691-4.
1991: Kanakura Y; Druker B; DiCarlo J; Cannistra S A; Griffin J D
Phorbol 12-myristate 13-acetate inhibits granulocyte-macrophage colony stimulating factor-induced protein tyrosine phosphorylation in a human factor-dependent hematopoietic cell line.
The Journal of biological chemistry 1991;266(1):490-5.
1991: Kanakura Y; Druker B; Wood K W; Mamon H J; Okuda K; Roberts T M; Griffin J D
Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce rapid phosphorylation and activation of the proto-oncogene Raf-1 in a human factor-dependent myeloid cell line.
Blood 1991;77(2):243-8.
1990: Furukawa Y; Piwnica-Worms H; Ernst T J; Kanakura Y; Griffin J D
cdc2 gene expression at the G1 to S transition in human T lymphocytes.
Science (New York, N.Y.) 1990;250(4982):805-8.
1990: Demetri G D; Ernst T J; Pratt E S; Zenzie B W; Rheinwald J G; Griffin J D
Expression of ras oncogenes in cultured human cells alters the transcriptional and posttranscriptional regulation of cytokine genes.
The Journal of clinical investigation 1990;86(4):1261-9.
1990: Sharkis S J; Jones R J; Bellis M L; Demetri G D; Griffin J D; Civin C; May W S
The action of bryostatin on normal human hematopoietic progenitors is mediated by accessory cell release of growth factors.
Blood 1990;76(4):716-20.
1990: Kanakura Y; Druker B; Cannistra S A; Furukawa Y; Torimoto Y; Griffin J D
Signal transduction of the human granulocyte-macrophage colony-stimulating factor and interleukin-3 receptors involves tyrosine phosphorylation of a common set of cytoplasmic proteins.
Blood 1990;76(4):706-15.
1990: Cannistra S A; Koenigsmann M; DiCarlo J; Groshek P; Griffin J D
Differentiation-associated expression of two functionally distinct classes of granulocyte-macrophage colony-stimulating factor receptors by human myeloid cells.
The Journal of biological chemistry 1990;265(21):12656-63.
1990: Nakamura M; Kanakura Y; Furukawa Y; Ernst T J; Griffin J D
Demonstration of interleukin-1 beta transcripts in acute myeloblastic leukemic cells by in situ hybridization.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1990;4(7):466-70.
1990: Griffin J D; Spertini O; Ernst T J; Belvin M P; Levine H B; Kanakura Y; Tedder T F
Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(2):576-84.
1990: Ord D C; Ernst T J; Zhou L J; Rambaldi A; Spertini O; Griffin J; Tedder T F
Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils.
The Journal of biological chemistry 1990;265(14):7760-7.
1990: Demetri G D; Griffin J D
Hematopoietic growth factors and high-dose chemotherapy: will grams succeed where milligrams fail?
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1990;8(5):761-4.
1990: Furukawa Y; DeCaprio J A; Freedman A; Kanakura Y; Nakamura M; Ernst T J; Livingston D M; Griffin J D
Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(7):2770-4.
1990: Griffin J D; Cannistra S A; Sullivan R; Demetri G D; Ernst T J; Kanakura Y
The biology of GM-CSF: regulation of production and interaction with its receptor.
International journal of cell cloning 1990;8 Suppl 1():35-44; discussion 44-5.
1990: Cannistra S A; Groshek P; Garlick R; Miller J; Griffin J D
Regulation of surface expression of the granulocyte/macrophage colony-stimulating factor receptor in normal human myeloid cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(1):93-7.
1990: Griffin J D; Demetri G D; Kanakura Y; Cannistra S A; Ernst T J
Cellular interaction regulating the production of colony-stimulating factors.
Progress in clinical and biological research 1990;338():129-41.
1989: Nakamura M; Merchav S; Carter A; Ernst T J; Demetri G D; Furukawa Y; Anderson K; Freedman A S; Griffin J D
Expression of a novel 3.5-kb macrophage colony-stimulating factor transcript in human myeloma cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(11):3543-7.
1989: Bauer K A; Conway E M; Bach R; Konigsberg W H; Griffin J D; Demetri G
Tissue factor gene expression in acute myeloblastic leukemia.
Thrombosis research 1989;56(3):425-30.
1989: DeCaprio J A; Ludlow J W; Lynch D; Furukawa Y; Griffin J; Piwnica-Worms H; Huang C M; Livingston D M
The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element.
Cell 1989;58(6):1085-95.
1989: Demetri G D; Griffin J D
Hemopoietins and leukemia.
Hematology/oncology clinics of North America 1989;3(3):535-53.
1989: Ernst T J; Ritchie A R; O'Rourke R; Griffin J D
Colony-stimulating factor gene expression in human acute myeloblastic leukemia cells is posttranscriptionally regulated.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1989;3(9):620-5.
1989: Demetri G D; Zenzie B W; Rheinwald J G; Griffin J D
Expression of colony-stimulating factor genes by normal human mesothelial cells and human malignant mesothelioma cells lines in vitro.
Blood 1989;74(3):940-6.
1989: Keinänen M; Bloomfield C D; Machnicki J; Griffin J D; de la Chapelle A
Human bone marrow cytogenetics: growth factors stimulate metaphases for specific lineages.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1989;3(6):405-12.
1989: Cannistra S A; Groshek P; Griffin J D
Granulocyte-macrophage colony-stimulating factor enhances the cytotoxic effects of cytosine arabinoside in acute myeloblastic leukemia and in the myeloid blast crisis phase of chronic myeloid leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1989;3(5):328-34.
1989: Sullivan R; Fredette J P; Leavitt J L; Gadenne A S; Griffin J D; Simons E R
Effects of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSFrh) on transmembrane electrical potentials in granulocytes: relationship between enhancement of ligand-mediated depolarization and augmentation of superoxide anion (O2-) production.
Journal of cellular physiology 1989;139(2):361-9.
1989: Ball E D; McDermott J; Griffin J D; Davey F R; Davis R; Bloomfield C D
Expression of the three myeloid cell-associated immunoglobulin G Fc receptors defined by murine monoclonal antibodies on normal bone marrow and acute leukemia cells.
Blood 1989;73(7):1951-6.
1989: Ernst T J; Ritchie A R; Demetri G D; Griffin J D
Regulation of granulocyte- and monocyte-colony stimulating factor mRNA levels in human blood monocytes is mediated primarily at a post-transcriptional level.
The Journal of biological chemistry 1989;264(10):5700-3.
1989: Sullivan R; Fredette J P; Socinski M; Elias A; Antman K; Schnipper L; Griffin J D
Enhancement of superoxide anion release by granulocytes harvested from patients receiving granulocyte-macrophage colony-stimulating factor.
British journal of haematology 1989;71(4):475-9.
1989: Sullivan R; Fredette J P; Griffin J D; Leavitt J L; Simons E R; Melnick D A
An elevation in the concentration of free cytosolic calcium is sufficient to activate the oxidative burst of granulocytes primed with recombinant human granulocyte-macrophage colony-stimulating factor.
The Journal of biological chemistry 1989;264(11):6302-9.
1989: Davey F R; Davis R B; MacCallum J M; Nelson D A; Mayer R J; Ball E D; Griffin J D; Schiffer C A; Bloomfield C D
Morphologic and cytochemical characteristics of acute promyelocytic leukemia.
American journal of hematology 1989;30(4):221-7.
1989: Griffin J D
Hemopoietins in oncology: factoring out myelosuppression.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1989;7(2):151-5.
1989: Rosmarin A G; Weil S C; Rosner G L; Griffin J D; Arnaout M A; Tenen D G
Differential expression of CD11b/CD18 (Mo1) and myeloperoxidase genes during myeloid differentiation.
Blood 1989;73(1):131-6.
1989: Herrmann F; Cannistra S A; Lindemann A; Blohm D; Rambaldi A; Mertelsmann R H; Griffin J D
Functional consequences of monocyte IL-2 receptor expression. Induction of IL-1 beta secretion by IFN gamma and IL-2.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(1):139-43.
1989: Ernst T J; Griffin J D
Regulation of colony-stimulating factor production by normal and leukemic human cells.
Immunologic research 1989;8(3):202-14.
1989: Holland C A; Rothstein L; Sakakeeny M A; Anklesaria P; Griffin J D; Harigaya K; Newburger P E; Greenberger J S
Infection of hematopoietic and stromal cells in human continuous bone marrow cultures by a retroviral vector containing the neomycin resistance gene.
Acta haematologica 1989;82(3):136-43.
1989: Chang H C; Hsu F; Freeman G J; Griffin J D; Reinherz E L
Cloning and expression of a gamma-interferon-inducible gene in monocytes: a new member of a cytokine gene family.
International immunology 1989;1(4):388-97.
1989: Herrmann F; Lindemann A; Cannistra S A; Brach M; Oster W; Griffin J D; Mertelsmann R
Monocyte interleukin-1 secretion is regulated by the sequential action of gamma-interferon and interleukin-2 involving monocyte surface expression of interleukin-2 receptors.
Haematology and blood transfusion 1989;32():299-315.
1988: Ernst T J; Rosenthal D S; Griffin J D; Canellos G P
Treatment of the blastic phase of chronic myelogenous leukemia with high-dose cytosine arabinoside.
American journal of clinical oncology 1988;11(6):623-6.
1988: Cannistra S A; Groshek P; Griffin J D
Monocytes enhance gamma-interferon-induced inhibition of myeloid progenitor cell growth through secretion of tumor necrosis factor.
Experimental hematology 1988;16(10):865-70.
1988: Sullivan R; Griffin J D; Wright J; Melnick D A; Leavitt J L; Fredette J P; Horne J H; Lyman C A; Lazzari K G; Simons E R
Effects of recombinant human granulocyte-macrophage colony-stimulating factor on intracellular pH in mature granulocytes.
Blood 1988;72(5):1665-73.
1988: Antman K S; Griffin J D; Elias A; Socinski M A; Ryan L; Cannistra S A; Oette D; Whitley M; Frei E; Schnipper L E
Effect of recombinant human granulocyte-macrophage colony-stimulating factor on chemotherapy-induced myelosuppression.
The New England journal of medicine 1988;319(10):593-8.
1988: Socinski M A; Cannistra S A; Sullivan R; Elias A; Antman K; Schnipper L; Griffin J D
Granulocyte-macrophage colony-stimulating factor induces the expression of the CD11b surface adhesion molecule on human granulocytes in vivo.
Blood 1988;72(2):691-7.
1988: Wang J M; Griffin J D; Rambaldi A; Chen Z G; Mantovani A
Induction of monocyte migration by recombinant macrophage colony-stimulating factor.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(2):575-9.
1988: Cannistra S A; Griffin J D
Regulation of the production and function of granulocytes and monocytes.
Seminars in hematology 1988;25(3):173-88.
1988: Young D C; Demetri G D; Ernst T J; Cannistra S A; Griffin J D
In vitro expression of colony-stimulating factor genes by human acute myeloblastic leukemia cells.
Experimental hematology 1988;16(5):378-82.
1988: Vellenga E; Rambaldi A; Ernst T J; Ostapovicz D; Griffin J D
Independent regulation of M-CSF and G-CSF gene expression in human monocytes.
Blood 1988;71(6):1529-32.
1988: Keinänen M; Griffin J D; Bloomfield C D; Machnicki J; de la Chapelle A
Clonal chromosomal abnormalities showing multiple-cell-lineage involvement in acute myeloid leukemia.
The New England journal of medicine 1988;318(18):1153-8.
1988: Socinski M A; Cannistra S A; Elias A; Antman K H; Schnipper L; Griffin J D
Granulocyte-macrophage colony stimulating factor expands the circulating haemopoietic progenitor cell compartment in man.
Lancet 1988;1(8596):1194-8.
1988: Herrmann F; Griffin J D; Sabbath K D; Oster W; Wernet P; Mertelsmann R
Identification and purification of human erythroid progenitor cells by monoclonal antibody to the transferrin receptor (TU 67).
Blut 1988;56(4):179-83.
1988: Rambaldi A; Wakamiya N; Vellenga E; Horiguchi J; Warren M K; Kufe D; Griffin J D
Expression of the macrophage colony-stimulating factor and c-fms genes in human acute myeloblastic leukemia cells.
The Journal of clinical investigation 1988;81(4):1030-5.
1988: Cannistra S A; Vellenga E; Groshek P; Rambaldi A; Griffin J D
Human granulocyte-monocyte colony-stimulating factor and interleukin 3 stimulate monocyte cytotoxicity through a tumor necrosis factor-dependent mechanism.
Blood 1988;71(3):672-6.
1988: Simpson P J; Todd R F; Fantone J C; Mickelson J K; Griffin J D; Lucchesi B R
Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo1, anti-CD11b) that inhibits leukocyte adhesion.
The Journal of clinical investigation 1988;81(2):624-9.
1988: Griffin J D
Clinical applications of colony-stimulating factors.
Oncology (Williston Park, N.Y.) 1988;2(1):15-23.
1987: Vellenga E; Griffin J D
The biology of acute myeloblastic leukemia.
Seminars in oncology 1987;14(4):365-71.
1987: Griffin J D
Growth factors required for proliferation of clonogenic cells in acute myeloblastic leukemia (AML).
Haematologica 1987;72(6 Suppl):85-8.
1987: Sullivan R; Griffin J D; Simons E R; Schafer A I; Meshulam T; Fredette J P; Maas A K; Gadenne A S; Leavitt J L; Melnick D A
Effects of recombinant human granulocyte and macrophage colony-stimulating factors on signal transduction pathways in human granulocytes.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(10):3422-30.
1987: Sullivan R; Griffin J D; Malech H L
Acquisition of formyl peptide receptors during normal human myeloid differentiation.
Blood 1987;70(4):1222-4.
1987: Griffin J D; Rambaldi A; Vellenga E; Young D C; Ostapovicz D; Cannistra S A
Secretion of interleukin-1 by acute myeloblastic leukemia cells in vitro induces endothelial cells to secrete colony stimulating factors.
Blood 1987;70(4):1218-21.
1987: Vellenga E; Ostapovicz D; O'Rourke B; Griffin J D
Effects of recombinant IL-3, GM-CSF, and G-CSF on proliferation of leukemic clonogenic cells in short-term and long-term cultures.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1987;1(8):584-9.
1987: Vellenga E; Young D C; Wagner K; Wiper D; Ostapovicz D; Griffin J D
The effects of GM-CSF and G-CSF in promoting growth of clonogenic cells in acute myeloblastic leukemia.
Blood 1987;69(6):1771-6.
1987: Kufe D W; Spriggs D R; Griffin J D
Pharmacologic studies of low-dose and high-dose continuous infusion cytosine arabinoside.
Seminars in oncology 1987;14(2 Suppl 1):149-58.
1987: Cannistra S A; Rambaldi A; Spriggs D R; Herrmann F; Kufe D; Griffin J D
Human granulocyte-macrophage colony-stimulating factor induces expression of the tumor necrosis factor gene by the U937 cell line and by normal human monocytes.
The Journal of clinical investigation 1987;79(6):1720-8.
1987: Rambaldi A; Young D C; Griffin J D
Expression of the M-CSF (CSF-1) gene by human monocytes.
Blood 1987;69(5):1409-13.
1987: Boyd A W; Tedder T F; Griffin J D; Freedman A S; Fisher D C; Daley J; Nadler L M
Preexposure of resting B cells to interferon-gamma enhances their proliferative response to subsequent activation signals.
Cellular immunology 1987;106(2):355-65.
1987: Sobol R E; Mick R; Royston I; Davey F R; Ellison R R; Newman R; Cuttner J; Griffin J D; Collins H; Nelson D A
Clinical importance of myeloid antigen expression in adult acute lymphoblastic leukemia.
The New England journal of medicine 1987;316(18):1111-7.
1987: Band H; Corredor V; Lustgarten J; Huebner K; Griffin J D; Kufe D W; Yunis E J
Southern blot analysis of BII cell line--a putative variant of HL-60.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1987;1(2):142-5.
1987: Sullivan R; Melnick D A; Malech H L; Meshulam T; Simons E R; Lazzari K G; Proto P J; Gadenne A S; Leavitt J L; Griffin J D
The effects of phorbol myristate acetate and chemotactic peptide on transmembrane potentials and cytosolic free calcium in mature granulocytes evolve sequentially as the cells differentiate.
The Journal of biological chemistry 1987;262(3):1274-81.
1987: Young D C; Wagner K; Griffin J D
Constitutive expression of the granulocyte-macrophage colony-stimulating factor gene in acute myeloblastic leukemia.
The Journal of clinical investigation 1987;79(1):100-6.
1987: Rambaldi A; Young D C; Herrmann F; Cannistra S A; Griffin J D
Interferon-gamma induces expression of the interleukin 2 receptor gene in human monocytes.
European journal of immunology 1987;17(1):153-6.
1987: Herrmann F; Schmidt R E; Ritz J; Griffin J D
In vitro regulation of human hematopoiesis by natural killer cells: analysis at a clonal level.
Blood 1987;69(1):246-54.
1987: Griffin J D
The use of monoclonal antibodies in the characterization of myeloid leukemias.
Hematologic pathology 1987;1(2):81-91.
1987: Herrmann F; Oster W; Lindemann A; Ganser A; Dörken B; Knapp W; Griffin J D; Mertelsmann R
Leukemic colony-forming cells in acute myeloblastic leukemia: maturation hierarchy and growth conditions.
Haematology and blood transfusion 1987;31():185-90.
1986: Griffin J D; Löwenberg B
Clonogenic cells in acute myeloblastic leukemia.
Blood 1986;68(6):1185-95.
1986: Griffin J D; Davis R; Nelson D A; Davey F R; Mayer R J; Schiffer C; McIntyre O R; Bloomfield C D
Use of surface marker analysis to predict outcome of adult acute myeloblastic leukemia.
Blood 1986;68(6):1232-41.
1986: Young D C; Griffin J D
Autocrine secretion of GM-CSF in acute myeloblastic leukemia.
Blood 1986;68(5):1178-81.
1986: Griffin J D; Young D C
The role of colony stimulating factors in leukaemogenesis.
Clinics in haematology 1986;15(4):995-1002.
1986: Dana N; Styrt B; Griffin J D; Todd R F; Klempner M S; Arnaout M A
Two functional domains in the phagocyte membrane glycoprotein Mo1 identified with monoclonal antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(10):3259-63.
1986: Messner H A; Griffin J D
Biology of acute myeloid leukaemia.
Clinics in haematology 1986;15(3):641-67.
1986: Griffin J D
Management of chronic myelogenous leukemia.
Seminars in hematology 1986;23(3 Suppl 1):20-6.
1986: Griffin J D; Young D; Herrmann F; Wiper D; Wagner K; Sabbath K D
Effects of recombinant human GM-CSF on proliferation of clonogenic cells in acute myeloblastic leukemia.
Blood 1986;67(5):1448-53.
1986: Herrmann F; Cannistra S A; Griffin J D
T cell-monocyte interactions in the production of humoral factors regulating human granulopoiesis in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(8):2856-61.
1986: Hokland P; Kerndrup G; Griffin J D; Ellegaard J
Analysis of leukocyte differentiation antigens in blood and bone marrow from preleukemia (refractory anemia) patients using monoclonal antibodies.
Blood 1986;67(4):898-902.
1986: Herrmann F; Griffin J D; Meuer S G; Meyer zum Büschenfelde K H
Establishment of an interleukin 2-dependent T cell line derived from a patient with severe aplastic anemia, which inhibits in vitro hematopoiesis.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(5):1629-34.
1986: Cannistra S A; Herrmann F; Davis R; Nichols K; Griffin J D
Relationship between HLA-DR expression by normal myeloid progenitor cells and inhibition of colony growth by prostaglandin E. Implications for prostaglandin E resistance in chronic myeloid leukemia.
The Journal of clinical investigation 1986;77(1):13-20.
1985: Picus J; Holley K; Aldrich W R; Griffin J D; Letvin N L
A naturally occurring bone marrow-chimeric primate. II. Environment dictates restriction on cytolytic T lymphocyte-target cell interactions.
The Journal of experimental medicine 1985;162(6):2035-52.
1985: Griffin J D; Larcom P; Kufe D W
TPA induces differentiation of purified human myeloblasts in the absence of proliferation.
Experimental hematology 1985;13(10):1025-32.
1985: Avnstrøm S; Plesner T; Ralfkier E; Wilken M; Griffin J D; Nissen N I
Expression of an antigen defined by a monoclonal antibody (SA-1) on normal and malignant cells.
Scandinavian journal of haematology 1985;35(4):408-17.
1985: Griffin J D; Sabbath K D; Herrmann F; Larcom P; Nichols K; Kornacki M; Levine H; Cannistra S A
Differential expression of HLA-DR antigens in subsets of human CFU-GM.
Blood 1985;66(4):788-95.
1985: Herrmann F; Cannistra S A; Levine H; Griffin J D
Expression of interleukin 2 receptors and binding of interleukin 2 by gamma interferon-induced human leukemic and normal monocytic cells.
The Journal of experimental medicine 1985;162(3):1111-6.
1985: Sabbath K D; Griffin J D
Clonogenic cells in acute myeloblastic leukaemia.
Scandinavian journal of haematology 1985;35(3):251-6.
1985: Canellos G P; Griffin J D
Chronic granulocytic leukemia: the heterogeneity of stem cell differentiation within a single disease entity.
Seminars in oncology 1985;12(3):281-8.
1985: Boyd A W; Griffin J D
Detection of nonrandom clustering of colonies in agar culture.
Experimental hematology 1985;13(7):696-700.
1985: Griffin J D; Spriggs D; Wisch J S; Kufe D W
Treatment of preleukemic syndromes with continuous intravenous infusion of low-dose cytosine arabinoside.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1985;3(7):982-91.
1985: Koizumi S; Fine R L; Curt G A; Griffin J D; Chabner B A
Enrichment of myeloid progenitor cells from normal human bone marrow using an immune-rosette technique.
Experimental hematology 1985;13(6):560-5.
1985: Biondi A; Roach J A; Griffin J D; Todd R F
Mb1, a plasma membrane antigen selectively expressed by U-937 cells.
Blood 1985;66(1):135-42.
1985: Matutes E; Rodriguez B; Polli N; Tavares de Castro J; Parreira A; Andrews C; Griffin J D; Tindle R W; Catovsky D
Characterization of myeloid leukemias with monoclonal antibodies 3C5 and MY9.
Hematological oncology 1985;3(3):179-86.
1985: Griffin J D; Maguire M E; Mayer R J
Amsacrine in refractory acute leukemia.
Cancer treatment reports 1985;69(7-8):787-9.
1985: Kufe D W; Griffin J D; Spriggs D R
Cellular and clinical pharmacology of low-dose ara-C.
Seminars in oncology 1985;12(2 Suppl 3):200-7.
1985: Mabry M; Speak J A; Griffin J D; Stahel R A; Bernal S D
Use of SM-1 monoclonal antibody and human complement in selective killing of small cell carcinoma of the lung.
The Journal of clinical investigation 1985;75(5):1690-5.
1985: Hercend T; Griffin J D; Bensussan A; Schmidt R E; Edson M A; Brennan A; Murray C; Daley J F; Schlossman S F; Ritz J
Generation of monoclonal antibodies to a human natural killer clone. Characterization of two natural killer-associated antigens, NKH1A and NKH2, expressed on subsets of large granular lymphocytes.
The Journal of clinical investigation 1985;75(3):932-43.
1985: Bernal S D; Mabry M; Stahel R A; Griffin J D; Speak J A
Selective cytotoxicity of the SM1 monoclonal antibody towards small cell carcinoma of the lung.
Cancer research 1985;45(3):1026-32.
1985: Koizumi S; Curt G A; Fine R L; Griffin J D; Chabner B A
Formation of methotrexate polyglutamates in purified myeloid precursor cells from normal human bone marrow.
The Journal of clinical investigation 1985;75(3):1008-14.
1985: Sabbath K D; Ball E D; Larcom P; Davis R B; Griffin J D
Heterogeneity of clonogenic cells in acute myeloblastic leukemia.
The Journal of clinical investigation 1985;75(2):746-53.
1985: Cannistra S A; Daley J F; Larcom P; Griffin J D
Expression of Ia antigens on myeloid progenitor cells in chronic myeloid leukemia: direct analysis using partially purified colony-forming cells.
Blood 1985;65(2):414-22.
1985: Shkolnik T; Schlossman S F; Griffin J D
Acute undifferentiated leukemia: induction of partial differentiation by phorbol ester.
Leukemia research 1985;9(1):11-7.
1984: Griffin J D; Meuer S C; Schlossman S F; Reinherz E L
T cell regulation of myelopoiesis: analysis at a clonal level.
Journal of immunology (Baltimore, Md. : 1950) 1984;133(4):1863-8.
1984: Hokland P; Nadler L M; Griffin J D; Schlossman S F; Ritz J
Purification of common acute lymphoblastic leukemia antigen positive cells from normal human bone marrow.
Blood 1984;64(3):662-6.
1984: Griffin J D; Sullivan R; Beveridge R P; Larcom P; Schlossman S F
Induction of proliferation of purified human myeloid progenitor cells: a rapid assay for granulocyte colony-stimulating factors.
Blood 1984;63(4):904-11.
1984: Tantravahi R; Schwenn M; Henkle C; Nell M; Leavitt P R; Griffin J D; Weinstein H J
A pericentric inversion of chromosome 16 is associated with dysplastic marrow eosinophils in acute myelomonocytic leukemia.
Blood 1984;63(4):800-2.
1984: Griffin J D; Linch D; Sabbath K; Larcom P; Schlossman S F
A monoclonal antibody reactive with normal and leukemic human myeloid progenitor cells.
Leukemia research 1984;8(4):521-34.
1983: Wisch J S; Griffin J D; Kufe D W
Response of preleukemic syndromes to continuous infusion of low-dose cytarabine.
The New England journal of medicine 1983;309(26):1599-602.
1983: Griffin J D; Larcom P; Schlossman S F
Use of surface markers to identify a subset of acute myelomonocytic leukemia cells with progenitor cell properties.
Blood 1983;62(6):1300-3.
1983: Tantravahi R; Griffin J D; Henkle C; Leavitt P R; Mayer R J; Frei E
Immunological and cytogenetic studies in two cases of B-cell acute lymphoblastic leukemia (Burkitt's type).
Cancer genetics and cytogenetics 1983;10(2):167-75.
1983: Griffin J D; Mayer R J; Weinstein H J; Rosenthal D S; Coral F S; Beveridge R P; Schlossman S F
Surface marker analysis of acute myeloblastic leukemia: identification of differentiation-associated phenotypes.
Blood 1983;62(3):557-63.
1983: Schnitzer B; Lovett E J; Flint A; Hudson J L; Kahn L E; Bricker L J; Griffin J D
Microgranular acute promyelocytic leukemia diagnosed by flow cytometry.
The New England journal of medicine 1983;309(7):435.
1983: Anderson K C; Griffin J D; Bates M P; Slaughenhoupt B L; Schlossman S F; Nadler L M
Isolation and characterization of human B lymphocyte enriched populations. I. Purification of B cells by immune rosette depletion.
Journal of immunological methods 1983;61(3):283-92.
1983: Rosenthal P; Rimm I J; Umiel T; Griffin J D; Osathanondh R; Schlossman S F; Nadler L M
Ontogeny of human hematopoietic cells: analysis utilizing monoclonal antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1983;131(1):232-7.
1983: Griffin J D; Hercend T; Beveridge R; Schlossman S F
Characterization of an antigen expressed by human natural killer cells.
Journal of immunology (Baltimore, Md. : 1950) 1983;130(6):2947-51.
1983: Garnick M B; Griffin J D
Idiopathic thrombocytopenia in association with extragonadal germ cell cancer.
Annals of internal medicine 1983;98(6):926-7.
1983: Griffin J D; Tantravahi R; Canellos G P; Wisch J S; Reinherz E L; Sherwood G; Beveridge R P; Daley J F; Lane H; Schlossman S F
T-cell surface antigens in a patient with blast crisis of chronic myeloid leukemia.
Blood 1983;61(4):640-4.
1983: Griffin J D; Ritz J; Beveridge R P; Lipton J M; Daley J F; Schlossman S F
Expression of MY7 antigen on myeloid precursor cells.
International journal of cell cloning 1983;1(1):33-48.
1983: Letvin N L; Todd R F; Palley L S; Schlossman S F; Griffin J D
Conservation of myeloid surface antigens on primate granulocytes.
Blood 1983;61(2):408-10.
1983: Hokland P; Rosenthal P; Griffin J D; Nadler L M; Daley J; Hokland M; Schlossman S F; Ritz J
Purification and characterization of fetal hematopoietic cells that express the common acute lymphoblastic leukemia antigen (CALLA).
The Journal of experimental medicine 1983;157(1):114-29.
1983: Griffin J D; Todd R F; Ritz J; Nadler L M; Canellos G P; Rosenthal D; Gallivan M; Beveridge R P; Weinstein H; Karp D; Schlossman S F
Differentiation patterns in the blastic phase of chronic myeloid leukemia.
Blood 1983;61(1):85-91.
1983: Griffin J D; Beveridge R P; Schlossman S F
Effect of phorbol ester on differentiation of human myeloid colony forming cells (CFU-C).
Leukemia research 1983;7(1):43-9.
1983: Weiss R B; Moquin D; Adams J D; Griffin J D; Zimbler H
Electrocardiogram abnormalities induced by amsacrine.
Cancer chemotherapy and pharmacology 1983;10(2):133-4.
1982: Griffin J D; Beveridge R P; Schlossman S F
Isolation of myeloid progenitor cells from peripheral blood of chronic myelogenous leukemia patients.
Blood 1982;60(1):30-7.
1982: Bradley M K; Griffin J D; Livingston D M
Relationship of oligomerization to enzymatic and DNA-binding properties of the SV40 large T antigen.
Cell 1982;28(1):125-34.
1981: Griffin J D; Garnick M B
Eye toxicity of cancer chemotherapy: a review of the literature.
Cancer 1981;48(7):1539-49.
1981: Griffin J D; Ritz J; Nadler L M; Schlossman S F
Expression of myeloid differentiation antigens on normal and malignant myeloid cells.
The Journal of clinical investigation 1981;68(4):932-41.
1981: Nadler L M; Ritz J; Griffin J D; Todd R F; Reinherz E L; Schlossman S F
Diagnosis and treatment of human leukemias and lymphomas utilizing monoclonal antibodies.
Progress in hematology 1981;12():187-225.
1981: Todd R F; Griffin J D; Ritz J; Nadler L M; Abrams T; Schlossman S F
Expression of normal monocyte-macrophage differentiation antigens on HL60 promyelocytes undergoing differentiation induced by leukocyte-conditioned medium or phorbol diester.
Leukemia research 1981;5(6):491-5.
1981: Major P P; Griffin J D; Minden M; Kufe D W
A blast subclone of the HL-60 human promyelocytic cell line.
Leukemia research 1981;5(4-5):429-30.
1980: Spangler G J; Griffin J D; Rubin H; Livingston D M
Identification and initial characterization of a new low-molecular-weight virus-encoded T antigen in a line of simian virus 40-transformed cells.
Journal of virology 1980;36(2):488-98.
1980: Griffin J D; Spangler G; Livingston D M
Enzymatic activities associated with the SV40 large T antigen.
Cold Spring Harbor symposia on quantitative biology 1980;44 Pt 1,():113-22.

Sign-in to see more