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Timothy Griffin

Research Profile

Occupations

Proteomics

Procedures

Chemicals & Drugs

Concepts & Ideas

Anatomy

Saliva

Physiology

Living Beings

Saccharomyces cerevisiae

Co-author Network

Publications

TOP 3
Pratik Jagtap; Joel A Kooren; Thomas McGowan; Sean L Seymour; Matthew S Wroblewski; Jill Goslinga; Timothy J Griffin
A two-step database search method improves sensitivity in peptide sequence matches for metaproteomics and proteogenomics studies.
Susan K Van Riper; John V Carlis; Ebbing P de Jong; Timothy J Griffin
Mass spectrometry-based proteomics: basic principles and emerging technologies and directions.
Ebbing P de Jong; Timothy J Griffin
Online nanoscale ERLIC-MS outperforms RPLC-MS for shotgun proteomics in complex mixtures.

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All Publications

2013: Pratik Jagtap; Joel A Kooren; Thomas McGowan; Sean L Seymour; Matthew S Wroblewski; Jill Goslinga; Timothy J Griffin
A two-step database search method improves sensitivity in peptide sequence matches for metaproteomics and proteogenomics studies.
Proteomics 2013;13(8):1352-7.
2013: Susan K Van Riper; John V Carlis; Ebbing P de Jong; Timothy J Griffin
Mass spectrometry-based proteomics: basic principles and emerging technologies and directions.
Advances in experimental medicine and biology 2013;990():1-35.
2012: Ebbing P de Jong; Timothy J Griffin
Online nanoscale ERLIC-MS outperforms RPLC-MS for shotgun proteomics in complex mixtures.
Journal of proteome research 2012;11(10):5059-64.
2012: Young-Mi Kim; Matthew Stone; Yeon-Gil Kim; Jane R Dunlevy; Timothy J Griffin; Tae Hyun Hwang; Do-Hyung Kim
SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling.
Molecular cell 2012;46(6):833-46.
2012: Pratik Jagtap; Thomas McGowan; Rongxiao Sa; Sean L Seymour; Matthew D Stone; Edgar A Arriaga; Sricharan Bandhakavi; John Chilton; LeeAnn Higgins; Timothy J Griffin
Workflow for analysis of high mass accuracy salivary data set using MaxQuant and ProteinPilot search algorithm.
Proteomics 2012;12(11):1726-30.
2012: Pratik Jagtap; Thomas McGowan; Sricharan Bandhakavi; Timothy J Griffin; Sean Seymour; Zheng Jin Tu; Joel D Rudney
Deep metaproteomic analysis of human salivary supernatant.
Proteomics 2012;12(7):992-1001.
2012: Johanna R Reed; Yungil Ryu; Thomas C Beadnell; Timothy J Griffin; Matthew D Stone; Kathryn L Schwertfeger
Fibroblast growth factor receptor 1 activation in mammary tumor cells promotes macrophage recruitment in a CX3CL1-dependent manner.
PloS one 2012;7(9):e45877.
2011: Ebbing P de Jong; Joseph S Koopmeiners; Susan K van Riper; John V Carlis; Timothy J Griffin
Sample collection and handling considerations for peptidomic studies in whole saliva; implications for biomarker discovery.
Clinica chimica acta; international journal of clinical chemistry 2011;412(23-24):2284-8.
2011: Timothy J Griffin; Sricharan Bandhakavi
Dynamic range compression: a solution for proteomic biomarker discovery?
Bioanalysis 2011;3(18):2053-6.
2011: Matthew D Stone; X Chen; Thomas McGowan; Sricharan Bandhakavi; Bin Cheng; Nelson L Rhodus; Timothy J Griffin
Large-scale phosphoproteomics analysis of whole saliva reveals a distinct phosphorylation pattern.
Journal of proteome research 2011;10(4):1728-36.
2011: Sricharan Bandhakavi; Susan K Van Riper; Pierre N Tawfik; Matthew D Stone; Tufia Haddad; Nelson L Rhodus; John V Carlis; Timothy J Griffin
Hexapeptide libraries for enhanced protein PTM identification and relative abundance profiling in whole human saliva.
Journal of proteome research 2011;10(3):1052-61.
2011: Sricharan Bandhakavi; Todd W Markowski; Hongwei Xie; Timothy J Griffin
Three-dimensional peptide fractionation for highly sensitive nanoscale LC-based shotgun proteomic analysis of complex protein mixtures.
Methods in molecular biology (Clifton, N.J.) 2011;790():47-56.
2011: Joel A Kooren; Nelson L Rhodus; Chuanning Tang; Bryan J Horrigan; Pratik D Jagtap; Timothy J Griffin
Evaluating the potential of a novel oral lesion exudate collection method coupled with mass spectrometry-based proteomics for oral cancer biomarker discovery.
Clinical proteomics 2011;8():13.
2010: Getiria Onsongo; Matthew D Stone; Susan K Van Riper; John Chilton; Baolin Wu; LeeAnn Higgins; Troy Lund; John V Carlis; Timothy J Griffin
LTQ-iQuant: A freely available software pipeline for automated and accurate protein quantification of isobaric tagged peptide data from LTQ instruments.
Proteomics 2010;10(19):3533-8.
2010: Joon Chong Yee; Nitya M Jacob; Karthik P Jayapal; Yee-Jiun Kok; Robin Philp; Timothy J Griffin; Wei-Shou Hu
Global assessment of protein turnover in recombinant antibody producing myeloma cells.
Journal of biotechnology 2010;148(4):182-93.
2010: Mikel R Roe; Thomas F McGowan; LaDora V Thompson; Timothy J Griffin
Targeted 18O-labeling for improved proteomic analysis of carbonylated peptides by mass spectrometry.
Journal of the American Society for Mass Spectrometry 2010;21(7):1190-203.
2010: Karthik P Jayapal; Siguang Sui; Robin J Philp; Yee-Jiun Kok; Miranda G S Yap; Timothy J Griffin; Wei-Shou Hu
Multitagging proteomic strategy to estimate protein turnover rates in dynamic systems.
Journal of proteome research 2010;9(5):2087-97.
2010: Ebbing P de Jong; Hongwei Xie; Getiria Onsongo; Matthew D Stone; Xiao-Bing Chen; Joel A Kooren; Eric W Refsland; Robert J Griffin; Frank G Ondrey; Baolin Wu; Chap T Le; Nelson L Rhodus; John V Carlis; Timothy J Griffin
Quantitative proteomics reveals myosin and actin as promising saliva biomarkers for distinguishing pre-malignant and malignant oral lesions.
PloS one 2010;5(6):e11148.
2009: Sricharan Bandhakavi; Matthew D Stone; Getiria Onsongo; Susan K Van Riper; Timothy J Griffin
A dynamic range compression and three-dimensional peptide fractionation analysis platform expands proteome coverage and the diagnostic potential of whole saliva.
Journal of proteome research 2009;8(12):5590-600.
2008: Paul A Grimsrud; Hongwei Xie; Timothy J Griffin; David A Bernlohr
Oxidative stress and covalent modification of protein with bioactive aldehydes.
The Journal of biological chemistry 2008;283(32):21837-41.
2008: Hongwei Xie; Getiria Onsongo; Jonathan Popko; Ebbing P de Jong; Jing Cao; John V Carlis; Robert J Griffin; Nelson L Rhodus; Timothy J Griffin
Proteomics analysis of cells in whole saliva from oral cancer patients via value-added three-dimensional peptide fractionation and tandem mass spectrometry.
Molecular & cellular proteomics : MCP 2008;7(3):486-98.
2008: Karthik P Jayapal; Robin J Philp; Yee-Jiun Kok; Miranda G S Yap; David H Sherman; Timothy J Griffin; Wei-Shou Hu
Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor.
PloS one 2008;3(5):e2097.
2008: Sricharan Bandhakavi; Hongwei Xie; Brennon O'Callaghan; Hiroshi Sakurai; Do-Hyung Kim; Timothy J Griffin
Hsf1 activation inhibits rapamycin resistance and TOR signaling in yeast revealed by combined proteomic and genetic analysis.
PloS one 2008;3(2):e1598.
2007: Timothy J Griffin; Hongwei Xie; Sricharan Bandhakavi; Jonathan Popko; Archana Mohan; John V Carlis; LeeAnn Higgins
iTRAQ reagent-based quantitative proteomic analysis on a linear ion trap mass spectrometer.
Journal of proteome research 2007;6(11):4200-9.
2007: Timothy J Griffin; Gargi Seth; Hongwei Xie; Sricharan Bandhakavi; Wei-Shou Hu
Advancing mammalian cell culture engineering using genome-scale technologies.
Trends in biotechnology 2007;25(9):401-8.
2007: So-Yon Woo; Dong-Hwan Kim; Chang-Bong Jun; Young-Mi Kim; Emilie Vander Haar; Seong-il Lee; James W Hegg; Sricharan Bandhakavi; Timothy J Griffin; Do-Hyung Kim
PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.
The Journal of biological chemistry 2007;282(35):25604-12.
2007: Mikel R Roe; Hongwei Xie; Sricharan Bandhakavi; Timothy J Griffin
Proteomic mapping of 4-hydroxynonenal protein modification sites by solid-phase hydrazide chemistry and mass spectrometry.
Analytical chemistry 2007;79(10):3747-56.
2007: Hongwei Xie; Sricharan Bandhakavi; Mikel R Roe; Timothy J Griffin
Preparative peptide isoelectric focusing as a tool for improving the identification of lysine-acetylated peptides from complex mixtures.
Journal of proteome research 2007;6(5):2019-26.
2007: Paul A Grimsrud; Matthew J Picklo; Timothy J Griffin; David A Bernlohr
Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal.
Molecular & cellular proteomics : MCP 2007;6(4):624-37.
2007: Emilie Vander Haar; Seong-Il Lee; Sricharan Bandhakavi; Timothy J Griffin; Do-Hyung Kim
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.
Nature cell biology 2007;9(3):316-23.
2006: Mikel R Roe; Timothy J Griffin
Gel-free mass spectrometry-based high throughput proteomics: tools for studying biological response of proteins and proteomes.
Proteomics 2006;6(17):4678-87.
2006: Hongwei Xie; Timothy J Griffin
Trade-off between high sensitivity and increased potential for false positive peptide sequence matches using a two-dimensional linear ion trap for tandem mass spectrometry-based proteomics.
Journal of proteome research 2006;5(4):1003-9.
2005: Hongwei Xie; Nelson L Rhodus; Robert J Griffin; John V Carlis; Timothy J Griffin
A catalogue of human saliva proteins identified by free flow electrophoresis-based peptide separation and tandem mass spectrometry.
Molecular & cellular proteomics : MCP 2005;4(11):1826-30.
2005: Hongwei Xie; Sricharan Bandhakavi; Timothy J Griffin
Evaluating preparative isoelectric focusing of complex peptide mixtures for tandem mass spectrometry-based proteomics: a case study in profiling chromatin-enriched subcellular fractions in Saccharomyces cerevisiae.
Analytical chemistry 2005;77(10):3198-207.