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Jack Griffith

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Stefanie Hartman Chen; Jack D Griffith; Jody L Plank; Smaranda Willcox; Tao-shih Hsieh
Improved methods for creating migratable Holliday junction substrates.
Eric D Horowitz; K Shefaet Rahman; Brian D Bower; David J Dismuke; Michael R Falvo; Jack D Griffith; Stephen C Harvey; Aravind Asokan
Biophysical and ultrastructural characterization of adeno-associated virus capsid uncoating and genome release.
Katarina Visacka; Smaranda Willcox; Michaela Wimmerova; Jirí Fajkus; Jack D Griffith; Ctirad Hofr; Ivona Necasova; Jozef Nosek; Jana Pavlouskova; Regina Sepsiova; Lucia Simonicova; Lubomir Tomaska
Synergism of the two Myb domains of Tay1 protein results in high affinity binding to telomeres.

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2013: Stefanie Hartman Chen; Jack D Griffith; Jody L Plank; Smaranda Willcox; Tao-shih Hsieh
Improved methods for creating migratable Holliday junction substrates.
Nucleic acids research 2013;41(5):e60.
2013: Eric D Horowitz; K Shefaet Rahman; Brian D Bower; David J Dismuke; Michael R Falvo; Jack D Griffith; Stephen C Harvey; Aravind Asokan
Biophysical and ultrastructural characterization of adeno-associated virus capsid uncoating and genome release.
Journal of virology 2013;87(6):2994-3002.
2012: Katarina Visacka; Smaranda Willcox; Michaela Wimmerova; Jirí Fajkus; Jack D Griffith; Ctirad Hofr; Ivona Necasova; Jozef Nosek; Jana Pavlouskova; Regina Sepsiova; Lucia Simonicova; Lubomir Tomaska
Synergism of the two Myb domains of Tay1 protein results in high affinity binding to telomeres.
The Journal of biological chemistry 2012;287(38):32206-15.
2012: Yoshiyuki Shibata; Smaranda Willcox; Jeffrey R Gagan; Jack D Griffith; Pankaj Kumar; Ryan Layer; Anindya Dutta
Extrachromosomal microDNAs and chromosomal microdeletions in normal tissues.
Science (New York, N.Y.) 2012;336(6077):82-6.
2012: Xiumei Guo; Mehmet Kesimer; Jack D Griffith; Jing Lu; John K Sheehan; Gökhan Tolun; Qing Xu; Xunhai Zheng; Xiaoling Li
The NAD(+)-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status.
Scientific reports 2012;2():640.
2010: Juraj Kramara; Smaranda Willcox; Stanislava Gunisova; Slavomir Kinsky; Jozef Nosek; Jack D Griffith; Lubomir Tomaska
Tay1 protein, a novel telomere binding factor from Yarrowia lipolytica.
The Journal of biological chemistry 2010;285(49):38078-92.
2010: Ulrich Rass; Sarah A Compton; Joao Matos; Martin R Singleton; Stephen C Y Ip; Miguel G Blanco; Jack D Griffith; Stephen C West
Mechanism of Holliday junction resolution by the human GEN1 protein.
Genes & development 2010;24(14):1559-69.
2010: Sarah A Compton; Sezgin Ozgür; Jack D Griffith
Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy.
The Journal of biological chemistry 2010;285(18):13349-56.
2010: Jaakko L O Pohjoismäki; J Bradley Holmes; Stuart R Wood; Ming-Yao Yang; Takehiro Yasukawa; Aurelio Reyes; Laura J Bailey; Tricia J Cluett; Steffi Goffart; Smaranda Willcox; Rachel E Rigby; Andrew P Jackson; Johannes N Spelbrink; Jack D Griffith; Robert J Crouch; Howard T Jacobs; Ian J Holt
Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid.
Journal of molecular biology 2010;397(5):1144-55.
2010: Beiyu Liu; Gokben Yildirir; Jianyang Wang; Gökhan Tolun; Jack D Griffith; Paul T Englund
TbPIF1, a Trypanosoma brucei mitochondrial DNA helicase, is essential for kinetoplast minicircle replication.
The Journal of biological chemistry 2010;285(10):7056-66.
2010: Arnab Roy Chowdhury; Rahul P Bakshi; Jianyang Wang; Gokben Yildirir; Beiyu Liu; Valeria Pappas-Brown; Gökhan Tolun; Jack D Griffith; Theresa A Shapiro; Robert E Jensen; Paul T Englund
The killing of African trypanosomes by ethidium bromide.
PLoS pathogens 2010;6(12):e1001226.
2010: Evelina Basenko; Anthony J Cesare; Shilpa Iyer; Jack D Griffith; Michael J. McEachern
Telomeric circles are abundant in the stn1-M1 mutant that maintains its telomeres through recombination.
Nucleic acids research 2010;38(1):182-9.
2010: Mehmet Kesimer; Alexander M Makhov; Jack D Griffith; Pedro Verdugo; John K Sheehan
Unpacking a gel-forming mucin: a view of MUC5B organization after granular release.
American journal of physiology. Lung cellular and molecular physiology 2010;298(1):L15-22.
2009: Dirk Remus; Fabienne Beuron; Gökhan Tolun; Jack D Griffith; Edward P Morris; John F X Diffley
Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.
Cell 2009;139(4):719-30.
2009: Lubomir Tomaska; Jozef Nosek; Juraj Kramara; Jack D Griffith
Telomeric circles: universal players in telomere maintenance?
Nature structural & molecular biology 2009;16(10):1010-5.
2009: Jaakko L O Pohjoismäki; Steffi Goffart; Henna Tyynismaa; Smaranda Willcox; Tomomi Ide; Dongchon Kang; Anu Suomalainen; Pekka J Karhunen; Jack D Griffith; Ian J Holt; Howard T Jacobs
Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks.
The Journal of biological chemistry 2009;284(32):21446-57.
2009: Ioannis Manolaridis; Eleni Mumtsidu; Peter Konarev; Alexander M Makhov; Stephen W Fullerton; Andrea Sinz; Stefan Kalkhof; John E McGeehan; Peter D Cary; Jack D Griffith; Dmitri Svergun; Geoff G Kneale; Paul A Tucker
Structural and biophysical characterization of the proteins interacting with the herpes simplex virus 1 origin of replication.
The Journal of biological chemistry 2009;284(24):16343-53.
2009: Adrian Randall; Jack D Griffith
Structure of long telomeric RNA transcripts: the G-rich RNA forms a compact repeating structure containing G-quartets.
The Journal of biological chemistry 2009;284(21):13980-6.
2009: Alexander M Makhov; Anindito Sen; Xiong Yu; Martha N Simon; Jack D Griffith; Edward H Egelman
The bipolar filaments formed by herpes simplex virus type 1 SSB/recombination protein (ICP8) suggest a mechanism for DNA annealing.
Journal of molecular biology 2009;386(2):273-9.
2008: Markus Räschle; Puck Knipscheer; Puck Knipsheer; Milica Enoiu; Todor Angelov; Jingchuan Sun; Jack D Griffith; Tom Ellenberger; Orlando D Schärer; Johannes C Walter
Mechanism of replication-coupled DNA interstrand crosslink repair.
Cell 2008;134(6):969-80.
2008: Sarah A Compton; Gökhan Tolun; Ashwini S Kamath-Loeb; Lawrence A Loeb; Jack D Griffith
The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer.
The Journal of biological chemistry 2008;283(36):24478-83.
2008: Jack D Griffith; Smaranda Willcox; Dennis W Powers; Roger Nelson; Bonnie K Baxter
Discovery of abundant cellulose microfibers encased in 250 Ma Permian halite: a macromolecular target in the search for life on other planets.
Astrobiology 2008;8(2):215-28.
2008: Katherine T Etheridge; Sarah A Compton; Katharine S Barrientos; Sezgin Ozgur; Jack D Griffith; Christopher M Counter
Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation.
The Journal of biological chemistry 2008;283(11):6935-41.
2008: Marcela Raices; Ramiro Verdun; Sarah A Compton; Candy I Haggblom; Jack D Griffith; Andrew Dillin; Jan Karlseder
C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins.
Cell 2008;132(5):745-57.
2008: E Mumtsidu; Alexander M Makhov; Peter V Konarev; Dmitri I Svergun; Jack D Griffith; Paul Tucker
Structural features of the single-stranded DNA-binding protein of Epstein-Barr virus.
Journal of structural biology 2008;161(2):172-87.
2008: Jeonggu Sim; Sezgin Ozgur; Biing Yuan Lin; Jei-Hwa Yu; Thomas R Broker; Louise T Chow; Jack D Griffith
Remodeling of the human papillomavirus type 11 replication origin into discrete nucleoprotein particles and looped structures by the E2 protein.
Journal of molecular biology 2008;375(4):1165-77.
2008: Anthony J Cesare; Cindy Groff-Vindman; Sarah A Compton; Michael J. McEachern; Jack D Griffith
Telomere loops and homologous recombination-dependent telomeric circles in a Kluyveromyces lactis telomere mutant strain.
Molecular and cellular biology 2008;28(1):20-9.
2007: H Kenny Kuo; Jack D Griffith; Kenneth N Kreuzer
5-Azacytidine induced methyltransferase-DNA adducts block DNA replication in vivo.
Cancer research 2007;67(17):8248-54.
2007: Clara R Smith; Randolph B DePrince; Jennifer Dackor; Weigl Debra; Jack D Griffith; Magnus Persmark
Separation of topological forms of plasmid DNA by anion-exchange HPLC: shifts in elution order of linear DNA.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;854(1-2):121-7.
2007: Sarah A Compton; Jun-Hyuk Choi; Anthony J Cesare; Sezgin Ozgür; Jack D Griffith
Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells.
Cancer research 2007;67(4):1513-9.
2007: Nancy G Nossal; Alexander M Makhov; Paul Chastain; Charles E Jones; Jack D Griffith
Architecture of the bacteriophage T4 replication complex revealed with nanoscale biopointers.
The Journal of biological chemistry 2007;282(2):1098-108.
2007: Yuan Yuan; Sarah A Compton; Krzysztof Sobczak; Myrna G Stenberg; Charles A Thornton; Jack D Griffith; Maurice S Swanson
Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs.
Nucleic acids research 2007;35(16):5474-86.
2006: Nicole Fouché; Anthony J Cesare; Smaranda Willcox; Sezgin Ozgür; Sarah A Compton; Jack D Griffith
The basic domain of TRF2 directs binding to DNA junctions irrespective of the presence of TTAGGG repeats.
The Journal of biological chemistry 2006;281(49):37486-95.
2006: Nicole Fouché; Ian K Moon; Brian R Keppler; Jack D Griffith; Michael B Jarstfer
Electron microscopic visualization of telomerase from Euplotes aediculatus bound to a model telomere DNA.
Biochemistry 2006;45(31):9624-31.
2006: Beiyu Liu; Henrik Molina; Dario E Kalume; Akhilesh Pandey; Jack D Griffith; Paul T Englund
Role of p38 in replication of Trypanosoma brucei kinetoplast DNA.
Molecular and cellular biology 2006;26(14):5382-93.
2006: Alexander M Makhov; Jack D Griffith
Visualization of the annealing of complementary single-stranded DNA catalyzed by the herpes simplex virus type 1 ICP8 SSB/recombinase.
Journal of molecular biology 2006;355(5):911-22.
2006: YanShan Ji; Jing-Jin Gu; Alexander M Makhov; Jack D Griffith; Beverly S Mitchell
Regulation of the interaction of inosine monophosphate dehydrogenase with mycophenolic Acid by GTP.
The Journal of biological chemistry 2006;281(1):206-12.
2006: Weigl Debra; Mike J Molloy; Tim M Clayton; Jack D Griffith; Clara R Smith; Terry Steward; Barbara M Merrill; Randolph B Deprince; Carl S Jone; Magnus Persmark
Characterization of a topologically aberrant plasmid population from pilot-scale production of clinical-grade DNA.
Journal of biotechnology 2006;121(1):1-12.
2006: Nicole Fouché; Sezgin Ozgür; Debasmita Roy; Jack D Griffith
Replication fork regression in repetitive DNAs.
Nucleic acids research 2006;34(20):6044-50.
2005: Deepa Subramanian; Jack D Griffith
p53 Monitors replication fork regression by binding to "chickenfoot" intermediates.
The Journal of biological chemistry 2005;280(52):42568-72.
2005: Miguel Martin; Jaehyoung Cho; Anthony J Cesare; Jack D Griffith; Giuseppe Attardi
Termination factor-mediated DNA loop between termination and initiation sites drives mitochondrial rRNA synthesis.
Cell 2005;123(7):1227-40.
2005: Cindy Groff-Vindman; Anthony J Cesare; Shobhana Natarajan; Jack D Griffith; Michael J. McEachern
Recombination at long mutant telomeres produces tiny single- and double-stranded telomeric circles.
Molecular and cellular biology 2005;25(11):4406-12.
2005: Diane E Grove; Smaranda Willcox; Jack D Griffith; Floyd R Bryant
Differential single-stranded DNA binding properties of the paralogous SsbA and SsbB proteins from Streptococcus pneumoniae.
The Journal of biological chemistry 2005;280(12):11067-73.
2005: Jozef Nosek; Adriana Rycovska; Alexander M Makhov; Jack D Griffith; Lubomir Tomaska
Amplification of telomeric arrays via rolling-circle mechanism.
The Journal of biological chemistry 2005;280(11):10840-5.
2005: Deepa Subramanian; Jack D Griffith
Modulation of p53 binding to Holliday junctions and 3-cytosine bulges by phosphorylation events.
Biochemistry 2005;44(7):2536-44.
2004: Lubomir Tomaska; Smaranda Willcox; Judita Slezakova; Jozef Nosek; Jack D Griffith
Taz1 binding to a fission yeast model telomere: formation of telomeric loops and higher order structures.
The Journal of biological chemistry 2004;279(49):50764-72.
2004: Anthony J Cesare; Jack D Griffith
Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous t-loops.
Molecular and cellular biology 2004;24(22):9948-57.
2004: Alexander M Makhov; Deepa Subramanian; Elizabeth Holley-Guthrie; Shannon C Kenney; Jack D Griffith
The Epstein-Barr virus polymerase accessory factor BMRF1 adopts a ring-shaped structure as visualized by electron microscopy.
The Journal of biological chemistry 2004;279(39):40358-61.
2004: Funda Sar; Laura A Lindsey-Boltz; Deepa Subramanian; Deborah L Croteau; Stephanie Q Hutsell; Jack D Griffith; Aziz Sancar
Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures.
The Journal of biological chemistry 2004;279(38):39289-95.
2004: Nina Bacher Reuven; Smaranda Willcox; Jack D Griffith; Sandra K Weller
Catalysis of strand exchange by the HSV-1 UL12 and ICP8 proteins: potent ICP8 recombinase activity is revealed upon resection of dsDNA substrate by nuclease.
Journal of molecular biology 2004;342(1):57-71.
2004: Alexander M Makhov; Dianne W Taylor; Jack D Griffith
Two-dimensional crystallization of herpes simplex virus type 1 single-stranded DNA-binding protein, ICP8, on a lipid monolayer.
Biochimica et biophysica acta 2004;1701(1-2):101-8.
2004: Paul Chastain; Jayson L Bowers; Daniel G Lee; Stephen P Bell; Jack D Griffith
Mapping subunit location on the Saccharomyces cerevisiae origin recognition complex free and bound to DNA using a novel nanoscale biopointer.
The Journal of biological chemistry 2004;279(35):36354-62.
2003: Jack D Griffith
Establishing a dental practice in a rural, low-income county health department.
Journal of public health management and practice : JPHMP 2003;9(6):538-41.
2003: Anthony J Cesare; Nancy Quinney; Smaranda Willcox; Deepa Subramanian; Jack D Griffith
Telomere looping in P. sativum (common garden pea).
The Plant journal : for cell and molecular biology 2003;36(2):271-9.
2003: Zheng-Guo He; Lisa F Rezende; Smaranda Willcox; Jack D Griffith; Charles C Richardson
The carboxyl-terminal domain of bacteriophage T7 single-stranded DNA-binding protein modulates DNA binding and interaction with T7 DNA polymerase.
The Journal of biological chemistry 2003;278(32):29538-45.
2003: Lisa F Rezende; Smaranda Willcox; Jack D Griffith; Charles C Richardson
A single-stranded DNA-binding protein of bacteriophage T7 defective in DNA annealing.
The Journal of biological chemistry 2003;278(31):29098-105.
2003: Paul Chastain; Alexander M Makhov; Nancy G Nossal; Jack D Griffith
Architecture of the replication complex and DNA loops at the fork generated by the bacteriophage t4 proteins.
The Journal of biological chemistry 2003;278(23):21276-85.
2003: Vladimir P Bermudez; Laura A Lindsey-Boltz; Anthony J Cesare; Yoshimasa Maniwa; Jack D Griffith; Jerard Hurwitz; Aziz Sancar
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1633-8.
2003: Alexander M Makhov; Sam S K Lee; I Robert Lehman; Jack D Griffith
Origin-specific unwinding of herpes simplex virus 1 DNA by the viral UL9 and ICP8 proteins: visualization of a specific preunwinding complex.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):898-903.
2002: Alexandre A Vetcher; Marek Napierala; Ravi R Iyer; Paul Chastain; Jack D Griffith; Robert D Wells
Sticky DNA, a long GAA.GAA.TTC triplex that is formed intramolecularly, in the sequence of intron 1 of the frataxin gene.
The Journal of biological chemistry 2002;277(42):39217-27.
2002: Zhaolan Zhou; Jeonggu Sim; Jack D Griffith; Robin Reed
Purification and electron microscopic visualization of functional human spliceosomes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12203-7.
2002: Biing Yuan Lin; Alexander M Makhov; Jack D Griffith; Thomas R Broker; Louise T Chow
Chaperone proteins abrogate inhibition of the human papillomavirus (HPV) E1 replicative helicase by the HPV E2 protein.
Molecular and cellular biology 2002;22(18):6592-604.
2002: Qin Yang; Ran Zhang; Xin Wei Wang; Elisa A Spillare; Steven P Linke; Deepa Subramanian; Jack D Griffith; Ji Liang Li; Ian D Hickson; Jiang Cheng Shen; Lawrence A Loeb; Sharlyn J Mazur; Ettore Appella; Robert M Brosh; parimal karmakar; Vilhelm A Bohr; Curtis C Harris
The processing of Holliday junctions by BLM and WRN helicases is regulated by p53.
The Journal of biological chemistry 2002;277(35):31980-7.
2002: Lisa G DeFazio; Rachel M Stansel; Jack D Griffith; Gilbert Chu
Synapsis of DNA ends by DNA-dependent protein kinase.
The EMBO journal 2002;21(12):3192-200.
2002: Deepa Subramanian; Jack D Griffith
Interactions between p53, hMSH2-hMSH6 and HMG I(Y) on Holliday junctions and bulged bases.
Nucleic acids research 2002;30(11):2427-34.
2002: Keziban Unsal-Kaçmaz; Alexander M Makhov; Jack D Griffith; Aziz Sancar
Preferential binding of ATR protein to UV-damaged DNA.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6673-8.
2002: Jack D Griffith; Laura A Lindsey-Boltz; Aziz Sancar
Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy.
The Journal of biological chemistry 2002;277(18):15233-6.
2002: Lubomir Tomaska; Alexander M Makhov; Jack D Griffith; Jozef Nosek
t-Loops in yeast mitochondria.
Mitochondrion 2002;1(5):455-9.
2002: Rachel M Stansel; Deepa Subramanian; Jack D Griffith
p53 binds telomeric single strand overhangs and t-loop junctions in vitro.
The Journal of biological chemistry 2002;277(14):11625-8.
2002: Joonsoo Lee; Paul Chastain; Jack D Griffith; Charles C Richardson
Lagging strand synthesis in coordinated DNA synthesis by bacteriophage t7 replication proteins.
Journal of molecular biology 2002;316(1):19-34.
2001: Rachel M Stansel; Titia de Lange; Jack D Griffith
T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang.
The EMBO journal 2001;20(19):5532-40.
2001: N Degtyareva; Deepa Subramanian; Jack D Griffith
Analysis of the binding of p53 to DNAs containing mismatched and bulged bases.
The Journal of biological chemistry 2001;276(12):8778-84.
2001: Alexander Vologodskii; W Zhang; VV Rybenkov; AA Podtelezhnikov; Deepa Subramanian; Jack D Griffith; Nicholas R Cozzarelli
Mechanism of topology simplification by type II DNA topoisomerases.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3045-9.
2001: J L Muñoz-Jordán; George A M Cross; Titia de Lange; Jack D Griffith
t-loops at trypanosome telomeres.
The EMBO journal 2001;20(3):579-88.
2001: Lubomir Tomaska; Alexander M Makhov; Jozef Nosek; B Kucejova; Jack D Griffith
Electron microscopic analysis supports a dual role for the mitochondrial telomere-binding protein of Candida parapsilosis.
Journal of molecular biology 2001;305(1):61-9.
2000: Lubomir Tomaska; Jozef Nosek; Alexander M Makhov; A Pastorakova; Jack D Griffith
Extragenomic double-stranded DNA circles in yeast with linear mitochondrial genomes: potential involvement in telomere maintenance.
Nucleic acids research 2000;28(22):4479-87.
2000: Paul Chastain; Alexander M Makhov; Nancy G Nossal; Jack D Griffith
Analysis of the Okazaki fragment distributions along single long DNAs replicated by the bacteriophage T4 proteins.
Molecular cell 2000;6(4):803-14.
2000: D G Lee; Alexander M Makhov; RD Klemm; Jack D Griffith; Stephen P Bell
Regulation of origin recognition complex conformation and ATPase activity: differential effects of single-stranded and double-stranded DNA binding.
The EMBO journal 2000;19(17):4774-82.
2000: R Bagga; S Michalowski; R Sabnis; Jack D Griffith; Beverly M Emerson
HMG I/Y regulates long-range enhancer-dependent transcription on DNA and chromatin by changes in DNA topology.
Nucleic acids research 2000;28(13):2541-50.
2000: Amareth Lim; Alexander M Makhov; J Bond; Hideyo Inouye; L H Connors; Jack D Griffith; Bruce W Erickson; Daniel A Kirschner; C E Costello
Betabellins 15D and 16D, de Novo designed beta-sandwich proteins that have amyloidogenic properties.
Journal of structural biology 2000;130(2-3):363-70.
1999: DT Kirkpatrick; Y H Wang; Margaret Dominska; Jack D Griffith; Thomas D Petes
Control of meiotic recombination and gene expression in yeast by a simple repetitive DNA sequence that excludes nucleosomes.
Molecular and cellular biology 1999;19(11):7661-71.
1999: Amareth Lim; Alexander M Makhov; Matthew J Saderholm; Jack D Griffith; Bruce W Erickson
Biophysical characterization of betabellin 16D: a beta-sandwich protein that forms narrow fibrils which associate into broad ribbons.
Biochemical and biophysical research communications 1999;264(2):498-504.
1999: A Bianchi; Rachel M Stansel; Louise Fairall; Jack D Griffith; Daniela Rhodes; Titia de Lange
TRF1 binds a bipartite telomeric site with extreme spatial flexibility.
The EMBO journal 1999;18(20):5735-44.
1999: S Michalowski; J W Miller; Carl R Urbinati; M Paliouras; Maurice S Swanson; Jack D Griffith
Visualization of double-stranded RNAs from the myotonic dystrophy protein kinase gene and interactions with CUG-binding protein.
Nucleic acids research 1999;27(17):3534-42.
1999: Marila Cordeiro-Stone; Alexander M Makhov; L S Zaritskaya; Jack D Griffith
Analysis of DNA replication forks encountering a pyrimidine dimer in the template to the leading strand.
Journal of molecular biology 1999;289(5):1207-18.
1999: Peter Cherepanov; D Surratt; Jaan Toelen; Wim Pluymers; Jack D Griffith; Erik De Clercq; zeger debyser
Activity of recombinant HIV-1 integrase on mini-HIV DNA.
Nucleic acids research 1999;27(10):2202-10.
1999: Jack D Griffith; L Comeau; S Rosenfield; Rachel M Stansel; A Bianchi; H Moss; Titia de Lange
Mammalian telomeres end in a large duplex loop.
Cell 1999;97(4):503-14.
1999: N Sakamoto; Paul Chastain; Pawel Parniewski; K Ohshima; M Pandolfo; Jack D Griffith; Robert D Wells
Sticky DNA: self-association properties of long GAA.TTC repeats in R.R.Y triplex structures from Friedreich's ataxia.
Molecular cell 1999;3(4):465-75.
1999: Jack D Griffith; S Michalowski; Alexander M Makhov
Electron microscopy of DNA-protein complexes and chromatin.
Methods in enzymology 1999;304():214-30.
1998: JS Liu; SR Kuo; Alexander M Makhov; Doug Cyr; Jack D Griffith; Thomas R Broker; Louise T Chow
Human Hsp70 and Hsp40 chaperone proteins facilitate human papillomavirus-11 E1 protein binding to the origin and stimulate cell-free DNA replication.
The Journal of biological chemistry 1998;273(46):30704-12.
1998: Amareth Lim; Matthew J Saderholm; Alexander M Makhov; M Kroll; Y Yan; Lalith Perera; Jack D Griffith; Bruce W Erickson
Engineering of betabellin-15D: a 64 residue beta sheet protein that forms long narrow multimeric fibrils.
Protein science : a publication of the Protein Society 1998;7(7):1545-54.
1998: Joonsoo Lee; Paul Chastain; T Kusakabe; Jack D Griffith; Charles C Richardson
Coordinated leading and lagging strand DNA synthesis on a minicircular template.
Molecular cell 1998;1(7):1001-10.
1998: Jack D Griffith; A Bianchi; Titia de Lange
TRF1 promotes parallel pairing of telomeric tracts in vitro.
Journal of molecular biology 1998;278(1):79-88.
1998: K Park; zeger debyser; Stanley Tabor; Charles C Richardson; Jack D Griffith
Formation of a DNA loop at the replication fork generated by bacteriophage T7 replication proteins.
The Journal of biological chemistry 1998;273(9):5260-70.
1998: Christopher E Pearson; Y H Wang; Jack D Griffith; Richard R Sinden
Structural analysis of slipped-strand DNA (S-DNA) formed in (CTG)n. (CAG)n repeats from the myotonic dystrophy locus.
Nucleic acids research 1998;26(3):816-23.
1997: Tae-kyung Kim; T Lagrange; Yuh-Hwa Wang; Jack D Griffith; Danny Reinberg; Richard H. Ebright
Trajectory of DNA in the RNA polymerase II transcription preinitiation complex.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(23):12268-73.
1997: DJ Allen; Alexander M Makhov; M Grilley; J Taylor; Randy J Thresher; Paul Modrich; Jack D Griffith
MutS mediates heteroduplex loop formation by a translocation mechanism.
The EMBO journal 1997;16(14):4467-76.
1997: Jack D Griffith; S Lee; Y H Wang
Visualizing nucleic acids and their complexes using electron microscopy.
Current opinion in structural biology 1997;7(3):362-6.
1997: D Kong; Jack D Griffith; Charles C Richardson
Gene 4 helicase of bacteriophage T7 mediates strand transfer through pyrimidine dimers, mismatches, and nonhomologous regions.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):2987-92.
1997: S Lee; L Cavallo; Jack D Griffith
Human p53 binds Holliday junctions strongly and facilitates their cleavage.
The Journal of biological chemistry 1997;272(11):7532-9.
1996: Y H Wang; R Gellibolian; M Shimizu; R D Wells; Jack D Griffith
Long CCG triplet repeat blocks exclude nucleosomes: a possible mechanism for the nature of fragile sites in chromosomes.
Journal of molecular biology 1996;263(4):511-6.
1996: Y H Wang; Jack D Griffith
Methylation of expanded CCG triplet repeat DNA from fragile X syndrome patients enhances nucleosome exclusion.
The Journal of biological chemistry 1996;271(38):22937-40.
1996: Scott W Stevens; Jack D Griffith
Sequence analysis of the human DNA flanking sites of human immunodeficiency virus type 1 integration.
Journal of virology 1996;70(9):6459-62.
1996: Y H Wang; Jack D Griffith
The [(G/C)3NN]n motif: a common DNA repeat that excludes nucleosomes.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):8863-7.
1996: Alexander M Makhov; P E Boehmer; I Robert Lehman; Jack D Griffith
Visualization of the unwinding of long DNA chains by the herpes simplex virus type 1 UL9 protein and ICP8.
Journal of molecular biology 1996;258(5):789-99.
1996: Alexander M Makhov; P E Boehmer; I Robert Lehman; Jack D Griffith
The herpes simplex virus type 1 origin-binding protein carries out origin specific DNA unwinding and forms stem-loop structures.
The EMBO journal 1996;15(7):1742-50.
1996: S A Stanfield-Oakley; Jack D Griffith
Nucleosomal arrangement of HIV-1 DNA: maps generated from an integrated genome and an EBV-based episomal model.
Journal of molecular biology 1996;256(3):503-16.
1996: R Skaliter; Alexander M Makhov; Jack D Griffith; I Robert Lehman
Rolling circle DNA replication by extracts of herpes simplex virus type 1-infected human cells.
Journal of virology 1996;70(2):1132-6.
1995: Randy J Thresher; Alexander M Makhov; S D Hall; Richard D Kolodner; Jack D Griffith
Electron microscopic visualization of RecT protein and its complexes with DNA.
Journal of molecular biology 1995;254(3):364-71.
1995: Toru Nakamura; Y H Wang; A J Zaug; Jack D Griffith; Thomas R Cech
Relative orientation of RNA helices in a group 1 ribozyme determined by helix extension electron microscopy.
The EMBO journal 1995;14(19):4849-59.
1995: S M Notarnicola; K Park; Jack D Griffith; Charles C Richardson
A domain of the gene 4 helicase/primase of bacteriophage T7 required for the formation of an active hexamer.
The Journal of biological chemistry 1995;270(34):20215-24.
1995: S Lee; B Elenbaas; A Levine; Jack D Griffith
p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches.
Cell 1995;81(7):1013-20.
1995: H Zenick; Jack D Griffith
The role of specimen banking in risk assessment.
Environmental health perspectives 1995;103 Suppl 3():9-12.
1995: L W Lee; Jack D Griffith; H Zenick; Barbara S Hulka
Human tissue monitoring and specimen banking: opportunities for exposure assessment, risk assessment, and epidemiologic research.
Environmental health perspectives 1995;103 Suppl 3():3-8.
1995: R W Zeller; Jack D Griffith; J G Moore; C V Kirchhamer; Roy J Britten; Eric H Davidson
A multimerizing transcription factor of sea urchin embryos capable of looping DNA.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2989-93.
1995: Jack D Griffith; Alexander M Makhov; L Zawel; D Reinberg
Visualization of TBP oligomers binding and bending the HIV-1 and adeno promoters.
Journal of molecular biology 1995;246(5):576-84.
1995: Y H Wang; Jack D Griffith
Expanded CTG triplet blocks from the myotonic dystrophy gene create the strongest known natural nucleosome positioning elements.
Genomics 1995;25(2):570-3.
1994: F L Murphy; Y H Wang; Jack D Griffith; Thomas R Cech
Coaxially stacked RNA helices in the catalytic center of the Tetrahymena ribozyme.
Science (New York, N.Y.) 1994;265(5179):1709-12.
1994: D S Hsu; M Takahashi; E Delagoutte; E Bertrand-Burggraf; Y H Wang; B Norden; Robert Fuchs; Jack D Griffith; Aziz Sancar
Flow linear dichroism and electron microscopic analysis of protein-DNA complexes of a mutant UvrB protein that binds to but cannot kink DNA.
Journal of molecular biology 1994;241(5):645-50.
1994: Jack D Griffith; Alexander M Makhov; L Santiago-Lara; P Setlow
Electron microscopic studies of the interaction between a Bacillus subtilis alpha/beta-type small, acid-soluble spore protein with DNA: protein binding is cooperative, stiffens the DNA, and induces negative supercoiling.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(17):8224-8.
1994: Y H Wang; S Amirhaeri; S Kang; R D Wells; Jack D Griffith
Preferential nucleosome assembly at DNA triplet repeats from the myotonic dystrophy gene.
Science (New York, N.Y.) 1994;265(5172):669-71.
1994: Scott W Stevens; Jack D Griffith
Human immunodeficiency virus type 1 may preferentially integrate into chromatin occupied by L1Hs repetitive elements.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5557-61.
1994: Y H Wang; F L Murphy; Thomas R Cech; Jack D Griffith
Visualization of a tertiary structural domain of the Tetrahymena group I intron by electron microscopy.
Journal of molecular biology 1994;236(1):64-71.
1993: J M Pinsince; K A Muench; Floyd R Bryant; Jack D Griffith
Two mutant RecA proteins possessing pH-dependent strand exchange activity exhibit pH-dependent presynaptic filament formation.
Journal of molecular biology 1993;233(1):59-66.
1993: E Crooke; Randy J Thresher; D S Hwang; Jack D Griffith; Arthur Kornberg
Replicatively active complexes of DnaA protein and the Escherichia coli chromosomal origin observed in the electron microscope.
Journal of molecular biology 1993;233(1):16-24.
1993: MF Vine; Barbara S Hulka; B H Margolin; Kinh Truong; P C Hu; M M Schramm; Jack D Griffith; M McCann; R B Everson
Cotinine concentrations in semen, urine, and blood of smokers and nonsmokers.
American journal of public health 1993;83(9):1335-8.
1993: M T Howard; Jack D Griffith
A cluster of strong topoisomerase II cleavage sites is located near an integrated human immunodeficiency virus.
Journal of molecular biology 1993;232(4):1060-8.
1993: Y H Wang; Carl Bortner; Jack D Griffith
RecA binding to bulge- and mismatch-containing DNAs. Certain single base mismatches provide strong signals for RecA binding equal to multiple base bulges.
The Journal of biological chemistry 1993;268(23):17571-7.
1993: M Grilley; Jack D Griffith; Paul Modrich
Bidirectional excision in methyl-directed mismatch repair.
The Journal of biological chemistry 1993;268(16):11830-7.
1993: C Bortner; T R Hernandez; I Robert Lehman; Jack D Griffith
Herpes simplex virus 1 single-strand DNA-binding protein (ICP8) will promote homologous pairing and strand transfer.
Journal of molecular biology 1993;231(2):241-50.
1992: M T Howard; K Sandman; J N Reeve; Jack D Griffith
HMf, a histone-related protein from the hyperthermophilic archaeon Methanothermus fervidus, binds preferentially to DNA containing phased tracts of adenines.
Journal of bacteriology 1992;174(23):7864-7.
1992: J M Pinsince; Jack D Griffith
Early stages in RecA protein-catalyzed pairing. Analysis of coaggregate formation and non-homologous DNA contacts.
Journal of molecular biology 1992;228(2):409-20.
1992: Eric Alani; Randy J Thresher; Jack D Griffith; Richard D Kolodner
Characterization of DNA-binding and strand-exchange stimulation properties of y-RPA, a yeast single-strand-DNA-binding protein.
Journal of molecular biology 1992;227(1):54-71.
1992: Y T Kim; Stanley Tabor; C Bortner; Jack D Griffith; Charles C Richardson
Purification and characterization of the bacteriophage T7 gene 2.5 protein. A single-stranded DNA-binding protein.
The Journal of biological chemistry 1992;267(21):15022-31.
1992: M Uziel; N B Munro; D S Katz; Tuan Vo-Dinh; E A Zeighami; M D Waters; Jack D Griffith
DNA adduct formation by 12 chemicals with populations potentially suitable for molecular epidemiological studies.
Mutation research 1992;277(1):35-90.
1992: Y H Wang; P Barker; Jack D Griffith
Visualization of diagnostic heteroduplex DNAs from cystic fibrosis deletion heterozygotes provides an estimate of the kinking of DNA by bulged bases.
The Journal of biological chemistry 1992;267(7):4911-5.
1992: Randy J Thresher; Jack D Griffith
Electron microscopic visualization of DNA and DNA-protein complexes as adjunct to biochemical studies.
Methods in enzymology 1992;211():481-90.
1991: Y H Wang; M T Howard; Jack D Griffith
Phased adenine tracts in double-stranded RNA do not induce sequence-directed bending.
Biochemistry 1991;30(22):5443-9.
1991: Michael D Topal; Randy J Thresher; M Conrad; Jack D Griffith
NaeI endonuclease binding to pBR322 DNA induces looping.
Biochemistry 1991;30(7):2006-10.
1991: Y H Wang; Jack D Griffith
Effects of bulge composition and flanking sequence on the kinking of DNA by bulged bases.
Biochemistry 1991;30(5):1358-63.
1991: M T Howard; M P Lee; Tao-shih Hsieh; Jack D Griffith
Drosophila topoisomerase II-DNA interactions are affected by DNA structure.
Journal of molecular biology 1991;217(1):53-62.
1990: C Bortner; Jack D Griffith
Three-stranded paranemic joints: architecture, topological constraints and movement.
Journal of molecular biology 1990;215(4):623-34.
1990: Randy J Thresher; Jack D Griffith
Intercalators promote the binding of RecA protein to double-stranded DNA.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(13):5056-60.
1989: C H Hsieh; Jack D Griffith
Deletions of bases in one strand of duplex DNA, in contrast to single-base mismatches, produce highly kinked molecules: possible relevance to the folding of single-stranded nucleic acids.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(13):4833-7.
1989: L D Harris; Jack D Griffith
UvsY protein of bacteriophage T4 is an accessory protein for in vitro catalysis of strand exchange.
Journal of molecular biology 1989;206(1):19-27.
1989: S S Su; M Grilley; Randy J Thresher; Jack D Griffith; Paul Modrich
Gap formation is associated with methyl-directed mismatch correction under conditions of restricted DNA synthesis.
Genome / National Research Council Canada = Génome / Conseil national de recherches Canada 1989;31(1):104-11.
1988: S L Brenner; Adam Zlotnick; Jack D Griffith
RecA protein self-assembly. Multiple discrete aggregation states.
Journal of molecular biology 1988;204(4):959-72.
1988: L D Harris; Jack D Griffith
Formation of D loops by the UvsX protein of T4 bacteriophage: a comparison of the reaction catalyzed in the presence or absence of gene 32 protein.
Biochemistry 1988;27(18):6954-9.
1988: J C Register; Jack D Griffith
Direct visualization of RecA protein binding to and unwinding duplex DNA following the D-loop cycle.
The Journal of biological chemistry 1988;263(23):11029-32.
1988: K A Ryan; Theresa A Shapiro; C A Rauch; Jack D Griffith; Paul T Englund
A knotted free minicircle in kinetoplast DNA.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(16):5844-8.
1988: Randy J Thresher; G Christiansen; Jack D Griffith
Assembly of presynaptic filaments. Factors affecting the assembly of RecA protein onto single-stranded DNA.
Journal of molecular biology 1988;201(1):101-13.
1988: I Husain; Jack D Griffith; Aziz Sancar
Thymine dimers bend DNA.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(8):2558-62.
1988: C H Laundon; Jack D Griffith
Curved helix segments can uniquely orient the topology of supertwisted DNA.
Cell 1988;52(4):545-9.
1988: C H Hsieh; Jack D Griffith
The terminus of SV40 DNA replication and transcription contains a sharp sequence-directed curve.
Cell 1988;52(4):535-44.
1988: Jack D Griffith; L D Harris
DNA strand exchanges.
CRC critical reviews in biochemistry 1988;23 Suppl 1():S43-86.
1987: J C Register; G Christiansen; Jack D Griffith
Electron microscopic visualization of the RecA protein-mediated pairing and branch migration phases of DNA strand exchange.
The Journal of biological chemistry 1987;262(26):12812-20.
1987: L D Harris; Jack D Griffith
Visualization of the homologous pairing of DNA catalyzed by the bacteriophage T4 UvsX protein.
The Journal of biological chemistry 1987;262(19):9285-92.
1987: C H Laundon; Jack D Griffith
Cationic metals promote sequence-directed DNA bending.
Biochemistry 1987;26(13):3759-62.
1986: Jack D Griffith; M Bleyman; C A Rauch; P A Kitchin; Paul T Englund
Visualization of the bent helix in kinetoplast DNA by electron microscopy.
Cell 1986;46(5):717-24.
1986: Jack D Griffith; A Hochschild; Mark Ptashne
DNA loops induced by cooperative binding of lambda repressor.
Nature 1986;322(6081):750-2.
1986: G Christiansen; Jack D Griffith
Visualization of the paranemic joining of homologous DNA molecules catalyzed by the RecA protein of Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(7):2066-70.
1986: J C Register; Jack D Griffith
RecA protein filaments can juxtapose DNA ends: an activity that may reflect a function in DNA repair.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(3):624-8.
1986: Robert Duncan; Jack D Griffith; Janet Konefal
Comparison of plasma cholinesterase depression among workers occupationally exposed to organophosphorus pesticides as reported by various studies.
Journal of toxicology and environmental health 1986;18(1):1-11.
1985: J C Register; Jack D Griffith
The direction of RecA protein assembly onto single strand DNA is the same as the direction of strand assimilation during strand exchange.
The Journal of biological chemistry 1985;260(22):12308-12.
1985: Jack D Griffith; Robert Duncan
Urinary chlorobenzilate residues in citrus fieldworkers.
Bulletin of environmental contamination and toxicology 1985;35(4):496-9.
1985: Jack D Griffith; Robert Duncan
Serum organochlorine residues in Florida citrus workers compared to the National Health and Nutrition Examination Survey sample.
Bulletin of environmental contamination and toxicology 1985;35(3):411-7.
1985: Jack D Griffith; H A Nash
Genetic rearrangement of DNA induces knots with a unique topology: implications for the mechanism of synapsis and crossing-over.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(10):3124-8.
1985: Jack D Griffith; T Formosa
The uvsX protein of bacteriophage T4 arranges single-stranded and double-stranded DNA into similar helical nucleoprotein filaments.
The Journal of biological chemistry 1985;260(7):4484-91.
1985: Robert Duncan; Jack D Griffith
Monitoring study of urinary metabolites and selected symptomatology among Florida citrus workers.
Journal of toxicology and environmental health 1985;16(3-4):509-21.
1985: M Manning; Jack D Griffith
Association of M13 I-forms and spheroids with lipid vesicles.
Archives of biochemistry and biophysics 1985;236(1):297-303.
1985: Jack D Griffith; Carol G Shores
RecA protein rapidly crystallizes in the presence of spermidine: a valuable step in its purification and physical characterization.
Biochemistry 1985;24(1):158-62.
1985: J C Register; Jack D Griffith
10 nm RecA protein filaments formed in the presence of Mg2+ and ATP gamma S may contain RNA.
Molecular & general genetics : MGG 1985;199(3):415-20.
1984: Jack D Griffith; L D Harris; J Register
Visualization of SSB-ssDNA complexes active in the assembly of stable RecA-DNA filaments.
Cold Spring Harbor symposia on quantitative biology 1984;49():553-9.
1983: C L Moore; L Klevan; J C Wang; Jack D Griffith
Gyrase . DNA complexes visualized as looped structures by electron microscopy.
The Journal of biological chemistry 1983;258(7):4612-7.
1982: C L Moore; Jack D Griffith; J E Shaw
Filamentous structures associated with Epstein-Barr virus-infected cells.
Journal of virology 1982;43(1):305-13.
1982: Jack D Griffith; S Hester; S El Saidy
A duplex structure involving two non-complementary DNA strands can be formed and stabilized by M13 phage proteins.
Journal of molecular biology 1982;157(2):321-30.
1982: K Dunn; S Chrysogelos; Jack D Griffith
Electron microscopic visualization of recA-DNA filaments: evidence for a cyclic extension of duplex DNA.
Cell 1982;28(4):757-65.
1980: K Dunn; Jack D Griffith
The presence of RNA in a double helix inhibits its interaction with histone protein.
Nucleic acids research 1980;8(3):555-66.
1978: Jack D Griffith
DNA structure: evidence from electron microscopy.
Science (New York, N.Y.) 1978;201(4355):525-7.
1978: Jack D Griffith; G Christiansen
The multifunctional role of histone H1, probed with the SV40 minichromosome.
Cold Spring Harbor symposia on quantitative biology 1978;42 Pt 1():215-26.
1978: Jack D Griffith; G Christiansen
Electron microscope visualization of chromatin and other DNA-protein complexes.
Annual review of biophysics and bioengineering 1978;7():19-35.
1977: G Christiansen; Jack D Griffith
Salt and divalent cations affect the flexible nature of the natural beaded chromatin structure.
Nucleic acids research 1977;4(6):1837-51.
1977: G Christiansen; T Landers; Jack D Griffith; Paul Berg
Characterization of components released by alkali disruption of simian virus 40.
Journal of virology 1977;21(3):1079-84.
1976: Jack D Griffith
Visualization of prokaryotic DNA in a regularly condensed chromatin-like fiber.
Proceedings of the National Academy of Sciences of the United States of America 1976;73(2):563-7.
1975: Jack D Griffith; M Dieckmann; Paul Berg
Electron microscope localization of a protein bound near the origin of simian virus 40 DNA replication.
Journal of virology 1975;15(1):167-72.
1974: Jack D Griffith; A Kornberg
Mini M13 bacteriophage: circular fragments of M13 DNA are replicated and packaged during normal infections.
Virology 1974;59(1):139-52.
1973: Jack D Griffith
Electron microscopic visualization of DNA in association with cellular components.
Methods in cell biology 1973;7():129-46.