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Tudor Griffith

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David H Edwards; David C Ellinsworth; Yiwen Li; Tudor M Griffith
The effect of inorganic arsenic on endothelium-dependent relaxation: role of NADPH oxidase and hydrogen peroxide.
Dimitris Parthimos; Ole Schmiedel; John N Harvey; Tudor M Griffith
Deterministic nonlinear features of cutaneous perfusion are lost in diabetic subjects with neuropathy.
Cor De Wit; Tudor M Griffith
Connexins and gap junctions in the EDHF phenomenon and conducted vasomotor responses.

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All Publications

2013: David H Edwards; David C Ellinsworth; Yiwen Li; Tudor M Griffith
The effect of inorganic arsenic on endothelium-dependent relaxation: role of NADPH oxidase and hydrogen peroxide.
Toxicology 2013;306():50-8.
2011: Dimitris Parthimos; Ole Schmiedel; John N Harvey; Tudor M Griffith
Deterministic nonlinear features of cutaneous perfusion are lost in diabetic subjects with neuropathy.
Microvascular research 2011;82(1):42-51.
2010: Cor De Wit; Tudor M Griffith
Connexins and gap junctions in the EDHF phenomenon and conducted vasomotor responses.
Pflügers Archiv : European journal of physiology 2010;459(6):897-914.
2009: Sofia Fernandez-Rodriguez; David H Edwards; Ben Newton; Tudor M Griffith
Attenuated store-operated Ca2+ entry underpins the dual inhibition of nitric oxide and EDHF-type relaxations by iodinated contrast media.
Cardiovascular research 2009;84(3):470-8.
2009: Ambroise Garry; David H Edwards; Ian F Fallis; Robert L Jenkins; Tudor M Griffith
Ascorbic acid and tetrahydrobiopterin potentiate the EDHF phenomenon by generating hydrogen peroxide.
Cardiovascular research 2009;84(2):218-26.
2008: David H Edwards; Yiwen Li; Tudor M Griffith
Hydrogen peroxide potentiates the EDHF phenomenon by promoting endothelial Ca2+ mobilization.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(10):1774-81.
2007: Tudor M Griffith
Which connexins connect?
Circulation research 2007;101(12):1219-21.
2007: Dimitris Parthimos; Rebecca E Haddock; Caryl E Hill; Tudor M Griffith
Dynamics of a three-variable nonlinear model of vasomotion: comparison of theory and experiment.
Biophysical journal 2007;93(5):1534-56.
2007: David H Edwards; Andrew T Chaytor; Linda M Bakker; Tudor M Griffith
Modulation of gap-junction-dependent arterial relaxation by ascorbic acid.
Journal of vascular research 2007;44(5):410-22.
2006: Vladimir V Matchkov; Awahan Rahman; Linda M Bakker; Tudor M Griffith; Holger Nilsson; Christian Aalkjaer
Analysis of effects of connexin-mimetic peptides in rat mesenteric small arteries.
American journal of physiology. Heart and circulatory physiology 2006;291(1):H357-67.
2005: Tudor M Griffith; Andrew T Chaytor; Linda M Bakker; David H Edwards
5-Methyltetrahydrofolate and tetrahydrobiopterin can modulate electrotonically mediated endothelium-dependent vascular relaxation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(19):7008-13.
2005: Patricia E M Martin; Colin Wall; Tudor M Griffith
Effects of connexin-mimetic peptides on gap junction functionality and connexin expression in cultured vascular cells.
British journal of pharmacology 2005;144(5):617-27.
2005: F Gavazza; Felice Daverio; Andrew T Chaytor; Tudor M Griffith; Christopher McGuigan
Phosphoramidate derivatives of 2',5'-dideoxyadenosine as potential inhibitors of the EDHF phenomenon.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):553-5.
2005: Andrew T Chaytor; Linda M Bakker; David H Edwards; Tudor M Griffith
Connexin-mimetic peptides dissociate electrotonic EDHF-type signalling via myoendothelial and smooth muscle gap junctions in the rabbit iliac artery.
British journal of pharmacology 2005;144(1):108-14.
2004: Tudor M Griffith; Andrew T Chaytor; David H Edwards
The obligatory link: role of gap junctional communication in endothelium-dependent smooth muscle hyperpolarization.
Pharmacological research : the official journal of the Italian Pharmacological Society 2004;49(6):551-64.
2004: Dimitris Parthimos; Kurt Osterloh; Axel R Pries; Tudor M Griffith
Deterministic nonlinear characteristics of in vivo blood flow velocity and arteriolar diameter fluctuations.
Physics in medicine and biology 2004;49(9):1789-802.
2004: Tudor M Griffith; Andrew T Chaytor; David H Edwards; Felice Daverio; Christopher McGuigan
Enhanced inhibition of the EDHF phenomenon by a phenyl methoxyalaninyl phosphoramidate derivative of dideoxyadenosine.
British journal of pharmacology 2004;142(1):27-30.
2004: Tudor M Griffith
Endothelium-dependent smooth muscle hyperpolarization: do gap junctions provide a unifying hypothesis?
British journal of pharmacology 2004;141(6):881-903.
2003: Andrew T Chaytor; David H Edwards; Linda M Bakker; Tudor M Griffith
Distinct hyperpolarizing and relaxant roles for gap junctions and endothelium-derived H2O2 in NO-independent relaxations of rabbit arteries.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15212-7.
2003: Patricia E M Martin; Nathan S Hill; Bo Kristensen; Rachel J Errington; Tudor M Griffith
Ouabain exerts biphasic effects on connexin functionality and expression in vascular smooth muscle cells.
British journal of pharmacology 2003;140(7):1261-71.
2003: Dimitris Parthimos; David H Edwards; Tudor M Griffith
Shil'nikov homoclinic chaos is intimately related to type-III intermittency in isolated rabbit arteries: role of nitric oxide.
Physical review. E, Statistical, nonlinear, and soft matter physics 2003;67(5 Pt 1):051922.
2003: Hiroshi Ujiie; Andrew T Chaytor; Linda M Bakker; Tudor M Griffith
Essential role of Gap junctions in NO- and prostanoid-independent relaxations evoked by acetylcholine in rabbit intracerebral arteries.
Stroke; a journal of cerebral circulation 2003;34(2):544-50.
2002: Hiroshi Ujiie; David H Edwards; Tudor M Griffith
Endogenous nitric oxide synthesis differentially modulates pressure-flow and pressure-conductance relationships in the internal and external carotid artery circulations of the rat.
Neurologia medico-chirurgica 2002;42(12):527-34; discussion 535.
2002: Tudor M Griffith; Andrew T Chaytor; Hannah J Taylor; Beverley D Giddings; David H Edwards
cAMP facilitates EDHF-type relaxations in conduit arteries by enhancing electrotonic conduction via gap junctions.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(9):6392-7.
2002: Andrew T Chaytor; Hannah J Taylor; Tudor M Griffith
Gap junction-dependent and -independent EDHF-type relaxations may involve smooth muscle cAMP accumulation.
American journal of physiology. Heart and circulatory physiology 2002;282(4):H1548-55.
2002: Tudor M Griffith
Endothelial control of vascular tone by nitric oxide and gap junctions: a haemodynamic perspective.
Biorheology 2002;39(3-4):307-18.
2002: Rodney S Berman; Patricia E M Martin; W Howard Evans; Tudor M Griffith
Relative contributions of NO and gap junctional communication to endothelium-dependent relaxations of rabbit resistance arteries vary with vessel size.
Microvascular research 2002;63(1):115-28.
2001: Dimitris Parthimos; David H Edwards; Tudor M Griffith
Universal scaling properties of type-I intermittent chaos in isolated resistance arteries are unaffected by endogenous nitric oxide synthesis.
Physical review. E, Statistical, nonlinear, and soft matter physics 2001;64(6 Pt 1):061906.
2001: Andrew T Chaytor; Patricia E M Martin; David H Edwards; Tudor M Griffith
Gap junctional communication underpins EDHF-type relaxations evoked by ACh in the rat hepatic artery.
American journal of physiology. Heart and circulatory physiology 2001;280(6):H2441-50.
2001: Hannah J Taylor; Andrew T Chaytor; David H Edwards; Tudor M Griffith
Gap junction-dependent increases in smooth muscle cAMP underpin the EDHF phenomenon in rabbit arteries.
Biochemical and biophysical research communications 2001;283(3):583-9.
2000: IR Hutcheson; Tudor M Griffith
Role of phospholipase A(2) and myoendothelial gap junctions in melittin-induced arterial relaxation.
European journal of pharmacology 2000;406(2):239-45.
2000: David Harris; Patricia E M Martin; W Howard Evans; David A Kendall; Tudor M Griffith; Michael D Randall
Role of gap junctions in endothelium-derived hyperpolarizing factor responses and mechanisms of K(+)-relaxation.
European journal of pharmacology 2000;402(1-2):119-28.
2000: Andrew T Chaytor; Wendy L Marsh; IR Hutcheson; Tudor M Griffith
Comparison of glycyrrhetinic acid isoforms and carbenoxolone as inhibitors of EDHF-type relaxations mediated via gap junctions.
Endothelium : journal of endothelial cell research 2000;7(4):265-78.
1999: N Stamatis; Dimitris Parthimos; Tudor M Griffith
Forecasting chaotic cardiovascular time series with an adaptive slope multilayer perceptron neural network.
IEEE transactions on bio-medical engineering 1999;46(12):1441-53.
1999: Andrew T Chaytor; Patricia E M Martin; W Howard Evans; Michael D Randall; Tudor M Griffith
The endothelial component of cannabinoid-induced relaxation in rabbit mesenteric artery depends on gap junctional communication.
The Journal of physiology 1999;520 Pt 2():539-50.
1999: Tudor M Griffith; Hannah J Taylor
Cyclic AMP mediates EDHF-type relaxations of rabbit jugular vein.
Biochemical and biophysical research communications 1999;263(1):52-7.
1999: IR Hutcheson; Tudor M Griffith; M R Pitman; Rob Towart; M Gregersen; Helga Refsum; Jan Olof G Karlsson
Iodinated radiographic contrast media inhibit shear stress- and agonist-evoked release of NO by the endothelium.
British journal of pharmacology 1999;128(2):451-7.
1999: Dimitris Parthimos; David H Edwards; Tudor M Griffith
Minimal model of arterial chaos generated by coupled intracellular and membrane Ca2+ oscillators.
The American journal of physiology 1999;277(3 Pt 2):H1119-44.
1999: Kim A Dora; Patricia E M Martin; Andrew T Chaytor; W Howard Evans; Christopher J Garland; Tudor M Griffith
Role of heterocellular Gap junctional communication in endothelium-dependent smooth muscle hyperpolarization: inhibition by a connexin-mimetic peptide.
Biochemical and biophysical research communications 1999;254(1):27-31.
1999: IR Hutcheson; Andrew T Chaytor; W Howard Evans; Tudor M Griffith
Nitric oxide-independent relaxations to acetylcholine and A23187 involve different routes of heterocellular communication. Role of Gap junctions and phospholipase A2.
Circulation research 1999;84(1):53-63.
1999: Tudor M Griffith; David H Edwards
Integration of non-linear cellular mechanisms regulating microvascular perfusion.
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine 1999;213(5):369-83.
1998: Hannah J Taylor; Andrew T Chaytor; W Howard Evans; Tudor M Griffith
Inhibition of the gap junctional component of endothelium-dependent relaxations in rabbit iliac artery by 18-alpha glycyrrhetinic acid.
British journal of pharmacology 1998;125(1):1-3.
1998: Rodney S Berman; Tudor M Griffith
Spatial heterogeneity in the mechanisms contributing to acetylcholine-induced dilatation in the rabbit isolated ear.
British journal of pharmacology 1998;124(6):1245-53.
1998: Andrew T Chaytor; W Howard Evans; Tudor M Griffith
Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries.
The Journal of physiology 1998;508 ( Pt 2)():561-73.
1998: Sophie de Brouwer; David H Edwards; Tudor M Griffith
Simplification of the quasiperiodic route to chaos in agonist-induced vasomotion by iterative circle maps.
The American journal of physiology 1998;274(4 Pt 2):H1315-26.
1997: IR Hutcheson; Tudor M Griffith
Central role of intracellular calcium stores in acute flow- and agonist-evoked endothelial nitric oxide release.
British journal of pharmacology 1997;122(1):117-25.
1997: Andrew T Chaytor; W Howard Evans; Tudor M Griffith
Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries.
The Journal of physiology 1997;503 ( Pt 1)():99-110.
1997: David H Edwards; Tudor M Griffith
Entrained ion transport systems generate the membrane component of chaotic agonist-induced vasomotion.
The American journal of physiology 1997;273(2 Pt 2):H909-20.
1997: Tudor M Griffith; David H Edwards
Ca2+ sequestration as a determinant of chaos and mixed-mode dynamics in agonist-induced vasomotion.
The American journal of physiology 1997;272(4 Pt 2):H1696-709.
1997: Rodney S Berman; Tudor M Griffith
Differential actions of charybdotoxin on central and daughter branch arteries of the rabbit isolated ear.
British journal of pharmacology 1997;120(4):639-46.
1996: M R Pitman; Jan Olof Gustav Karlsson; Tudor M Griffith
Ionic mechanisms contributing to the vasorelaxant properties of iodinated contrast media: a comparison of iohexol and iodixanol in the rabbit isolated aorta.
British journal of pharmacology 1996;119(4):685-90.
1996: N Stamatis; Dimitris Parthimos; Tudor M Griffith
Prediction of arterial "burst" activity and transitions between chaotic attractors with a multilayer perceptron optimized by a new stopping criterion.
International journal of neural systems 1996;7(4):417-28.
1996: IR Hutcheson; Tudor M Griffith
Mechanotransduction through the endothelial cytoskeleton: mediation of flow- but not agonist-induced EDRF release.
British journal of pharmacology 1996;118(3):720-6.
1996: Dimitris Parthimos; David H Edwards; Tudor M Griffith
Comparison of chaotic and sinusoidal vasomotion in the regulation of microvascular flow.
Cardiovascular research 1996;31(3):388-99.
1996: Tudor M Griffith
Temporal chaos in the microcirculation.
Cardiovascular research 1996;31(3):342-58.
1995: Tudor M Griffith; David H Edwards
Complexity of chaotic vasomotion is insensitive to flow and pressure but can be regulated by external control.
The American journal of physiology 1995;269(2 Pt 2):H656-68.
1995: Neil D Pugh; Tudor M Griffith; Jan Olof Gustav Karlsson
Effects of iodinated contrast media on peripheral blood flow.
Acta radiologica. Supplementum 1995;399():155-63.
1995: Neil D Pugh; IR Hutcheson; D H Edwards; J O Nossen; Jan Olof Gustav Karlsson; Tudor M Griffith
Angiographic contrast media relax isolated rabbit aorta through an endothelium-independent mechanism that may not depend on the presence of the iodine atom.
The British journal of radiology 1995;68(805):23-6.
1994: Tudor M Griffith
Modulation of blood flow and tissue perfusion by endothelium-derived relaxing factor.
Experimental physiology 1994;79(6):873-913.
1994: IR Hutcheson; J A Smith; Tudor M Griffith
Abolition of flow-dependent EDRF release before that evoked by agonists in hypercholesterolaemic rabbits.
British journal of pharmacology 1994;113(1):190-4.
1994: M D Randall; H Ujiie; Tudor M Griffith
L-arginine reverses the impairment of nitric oxide-dependent collateral perfusion in dietary-induced hypercholesterolaemia in the rabbit.
Clinical science (London, England : 1979) 1994;87(1):53-9.
1994: Tudor M Griffith; David H Edwards
EDRF suppresses chaotic pressure oscillations in isolated resistance artery without influencing intrinsic complexity.
The American journal of physiology 1994;266(5 Pt 2):H1786-800.
1994: M D Randall; H Ujiie; Tudor M Griffith
Modulation of vasodilatation to levcromakalim by adenosine analogues in the rabbit ear: an explanation for hypoxic augmentation.
British journal of pharmacology 1994;112(1):49-54.
1994: Tudor M Griffith; David H Edwards
Fractal analysis of role of smooth muscle Ca2+ fluxes in genesis of chaotic arterial pressure oscillations.
The American journal of physiology 1994;266(5 Pt 2):H1801-11.
1994: IR Hutcheson; Tudor M Griffith
Heterogeneous populations of K+ channels mediate EDRF release to flow but not agonists in rabbit aorta.
The American journal of physiology 1994;266(2 Pt 2):H590-6.
1993: Tudor M Griffith; D H Edwards
Modulation of chaotic pressure oscillations in isolated resistance arteries by EDRF.
European heart journal 1993;14 Suppl I():60-7.
1993: Tudor M Griffith; David H Edwards
Mechanisms underlying chaotic vasomotion in isolated resistance arteries: roles of calcium and EDRF.
Biorheology 1993;30(5-6):333-47.
1993: M D Randall; J A Smith; Tudor M Griffith
Hypercholesterolaemia severely impairs EDRF-dependent collateral perfusion following acute arterial occlusion in rabbit isolated ear.
British journal of pharmacology 1993;109(3):838-44.
1993: M D Randall; Tudor M Griffith
Modulation of vasodilatation to levcromakalim by hypoxia and EDRF in the rabbit isolated ear: a comparison with pinacidil, sodium nitroprusside and verapamil.
British journal of pharmacology 1993;109(2):386-93.
1992: M D Randall; Tudor M Griffith
EDRF plays central role in collateral flow after arterial occlusion in rabbit ear.
The American journal of physiology 1992;263(3 Pt 2):H752-60.
1992: M D Randall; Tudor M Griffith
Effects of BRL 38227, sodium nitroprusside and verapamil on collateral perfusion following acute arterial occlusion in the rabbit isolated ear.
British journal of pharmacology 1992;106(2):315-23.
1992: S Renowden; David H Edwards; Tudor M Griffith
Impaired cyclic nucleotide-mediated vasorelaxation may contribute to closure of the human umbilical artery after birth.
British journal of pharmacology 1992;106(2):348-53.
1992: David H Edwards; J V Byrne; Tudor M Griffith
The effect of chronic subarachnoid hemorrhage on basal endothelium-derived relaxing factor activity in intrathecal cerebral arteries.
Journal of neurosurgery 1992;76(5):830-7.
1992: M D Randall; Tudor M Griffith
Collateral perfusion: the role of endothelium-derived relaxing factor and effects of vasodilators.
Journal of cardiovascular pharmacology 1992;20 Suppl 12():S166-9.
1991: M D Randall; Tudor M Griffith
Differential effects of L-arginine on the inhibition by NG-nitro-L-arginine methyl ester of basal and agonist-stimulated EDRF activity.
British journal of pharmacology 1991;104(3):743-9.
1991: IR Hutcheson; Tudor M Griffith
Release of endothelium-derived relaxing factor is modulated both by frequency and amplitude of pulsatile flow.
The American journal of physiology 1991;261(1 Pt 2):H257-62.
1991: Tudor M Griffith; David H Edwards; M D Randall
Blood flow and optimal vascular topography: role of the endothelium.
Basic research in cardiology 1991;86 Suppl 2():89-96.
1990: M D Randall; David H Edwards; Tudor M Griffith
Activities of endothelin-1 in the vascular network of the rabbit ear: a microangiographic study.
British journal of pharmacology 1990;101(4):781-8.
1990: Tudor M Griffith; David H Edwards
Myogenic autoregulation of flow may be inversely related to endothelium-derived relaxing factor activity.
The American journal of physiology 1990;258(4 Pt 2):H1171-80.
1989: Tudor M Griffith; Andrew H Henderson
EDRF and the regulation of vascular tone.
International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation 1989;8(4):383-96.
1989: M I Christie; Tudor M Griffith; Malcolm J Lewis
A comparison of basal and agonist-stimulated release of endothelium-derived relaxing factor from different arteries.
British journal of pharmacology 1989;98(2):397-406.
1989: J V Byrne; Tudor M Griffith; David H Edwards; T J Harrison; K R Johnston
Investigation of the vasoconstrictor action of subarachnoid haemoglobin in the pig cerebral circulation in vivo.
British journal of pharmacology 1989;97(3):669-74.
1989: Tudor M Griffith; David H Edwards; R L Davies; Andrew H Henderson
The role of EDRF in flow distribution: a microangiographic study of the rabbit isolated ear.
Microvascular research 1989;37(2):162-77.
1988: Tudor M Griffith; E Fitzgerald; D L Cochlin
Osteomesopyknosis: benign axial osteosclerosis.
The British journal of radiology 1988;61(730):951-3.
1988: Tudor M Griffith; Malcolm J Lewis; A C Newby; Andrew H Henderson
Endothelium-derived relaxing factor.
Journal of the American College of Cardiology 1988;12(3):797-806.
1988: Tudor M Griffith; David H Edwards; R L Davies; T J Harrison; K T Evans
Endothelium-derived relaxing factor (EDRF) and resistance vessels in an intact vascular bed: a microangiographic study of the rabbit isolated ear.
British journal of pharmacology 1988;93(3):654-62.
1987: Tudor M Griffith; David H Edwards; R L Davies; T J Harrison; K T Evans
EDRF coordinates the behaviour of vascular resistance vessels.
Nature 1987;329(6138):442-5.
1987: Tudor M Griffith; David H Edwards; Andrew H Henderson
Unstimulated release of endothelium derived relaxing factor is independent of mitochondrial ATP generation.
Cardiovascular research 1987;21(8):565-8.