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Alexander Arlt

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Alexander Arlt; Susanne Müerköster; Heiner Schäfer
Targeting apoptosis pathways in pancreatic cancer.
Rainer Noth; Philip Rosenstiel; Heiner Schäfer; Stefan Schreiber; Eckhard Stüber; Thilo Wedel; Burkhard Bewig; Martina Böttner; Mark Ellrichmann; Claudia Geismann; Jochen Hampe; Robert Häsler; Alexander Arlt
Oral glutamine supplementation improves intestinal permeability dysfunction in a murine acute graft-vs.-host disease model.
Christian Jürgensen; Frank Neser; Michael Nothnagel; Stefan Schreiber; Ulrich Stölzel; Martin Zeitz; Alexander Arlt; Jana Brand; Jörg-Olaf Habeck; Jochen Hampe
Prognostic relevance of gastric cancer staging by endoscopic ultrasound.

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All Publications

2013: Alexander Arlt; Susanne Müerköster; Heiner Schäfer
Targeting apoptosis pathways in pancreatic cancer.
Cancer letters 2013;332(2):346-58.
2013: Rainer Noth; Philip Rosenstiel; Heiner Schäfer; Stefan Schreiber; Eckhard Stüber; Thilo Wedel; Burkhard Bewig; Martina Böttner; Mark Ellrichmann; Claudia Geismann; Jochen Hampe; Robert Häsler; Alexander Arlt
Oral glutamine supplementation improves intestinal permeability dysfunction in a murine acute graft-vs.-host disease model.
American journal of physiology. Gastrointestinal and liver physiology 2013;304(7):G646-54.
2013: Christian Jürgensen; Frank Neser; Michael Nothnagel; Stefan Schreiber; Ulrich Stölzel; Martin Zeitz; Alexander Arlt; Jana Brand; Jörg-Olaf Habeck; Jochen Hampe
Prognostic relevance of gastric cancer staging by endoscopic ultrasound.
Surgical endoscopy 2013;27(4):1124-9.
2012: Simone Lipinski; Maren Paulsen; Stefan Schreiber; Andreas Till; Konrad Aden; Alexander Arlt; Susanne Billmann-Born; Kai Sven Erdmann; Nils Grabe; Nina Hagemann; Robert Häsler; Gunnar Jacobs; Lars Kraemer; Philip Rosenstiel
RNAi screening identifies mediators of NOD2 signaling: implications for spatial specificity of MDP recognition.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(52):21426-31.
2012: Martina Böttner; Günther Deuschl; Jan-Hendrik Egberts; Tobias Fricke; Annette Fritscher-Ravens; Jonas Harde; Ines Hellwig; Alexander Arlt; Martina Barrenschee; Thomas Becker; Dimitri Zorenkov; Thilo Wedel
Expression pattern and localization of alpha-synuclein in the human enteric nervous system.
Neurobiology of disease 2012;48(3):474-80.
2012: Sebastian Zeissig; Alexander Arlt; Katharina Balschun; Jody L Baron; Esther Bosse; Rainer Günther; Jochen Hampe; Zongyi Hu; M Mahmood Hussain; Jahangir Iqbal; Arthur Kaser; T Jake Liang; D Branch Moody; Kazumoto Murata; Jean Publicover; Christoph Röcken; Stefan Schreiber; Lindsay Sweet; Richard S Blumberg
Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity.
Nature medicine 2012;18(7):1060-8.
2012: Rainer Noth; Stefan Schreiber; Eckhard Stüber; Burkhard Bewig; Jochen Hampe; Robert Häsler; Tanja Kühbacher; Susanna Nikolaus; Alexander Arlt
Anti-TNF-α antibodies improve intestinal barrier function in Crohn's disease.
Journal of Crohn's & colitis 2012;6(4):464-9.
2012: Ole Ammerpohl; Alexander Arlt; Katharina Balschun; Thomas Becker; Mario Brosch; Wladimir Faber; Jonas Grauholm; Andrea Haake; Holger Kalthoff; Peter Neuhaus; Johann Pratschke; Christoph Röcken; Clemens Schafmayer; Bodo Schniewind; Stefan Schreiber; Reiner Siebert; Bence Sipos; Felix Stickel; Oliver von Kampen; Witigo von Schönfels; Jochen Hampe
Distinct DNA methylation patterns in cirrhotic liver and hepatocellular carcinoma.
International journal of cancer. Journal international du cancer 2012;130(6):1319-28.
2012: Alexander Arlt; H Schäfer; Holger Kalthoff
The 'N-factors' in pancreatic cancer: functional relevance of NF-κB, NFAT and Nrf2 in pancreatic cancer.
Oncogenesis 2012;1():e35.
2012: Christian Jürgensen; Frank Neser; Ulrich Stölzel; Alexander Arlt; Annette Fritscher-Ravens; Jochen Hampe
Endoscopic ultrasound criteria to predict the need for intervention in pancreatic necrosis.
BMC gastroenterology 2012;12():48.
2011: W Erhart; N Maass; Alexander Arlt; N Arnold; Gabriele Brunke; F Wegener; Ö Alkasi; Ivo Meinhold-Heerlein
Induction of human β-defensins and psoriasin in vulvovaginal human papillomavirus-associated lesions.
The Journal of infectious diseases 2011;204(3):391-9.
2011: Susanne Billmann-Born; Andreas Till; Alexander Arlt; Simone Lipinski; Christian Sina; Anna Latiano; Vito Annese; Robert Häsler; Martin Kerick; Thomas Manke; Dirk Seegert; Adedayo Hanidu; Heiner Schäfer; David van Heel; Jun Li; Stefan Schreiber; Philip Rosenstiel
Genome-wide expression profiling identifies an impairment of negative feedback signals in the Crohn's disease-associated NOD2 variant L1007fsinsC.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(7):4027-38.
2011: Claudia Kürbitz; Daniel Heise; Torben Redmer; Freya Goumas; Alexander Arlt; Johannes Lemke; Gerald Rimbach; Holger Kalthoff; Anna Trauzold
Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells.
Cancer science 2011;102(4):728-34.
2011: Rene Pahl; Gabriele Brunke; Nadine Steubesand; Sabine Schubert; Martina Böttner; Thilo Wedel; Christian Jürgensen; Jochen Hampe; Heiner Schäfer; Sebastian Zeissig; Stefan Schreiber; Philip Rosenstiel; Karina Reiss; Alexander Arlt
IL-1β and ADAM17 are central regulators of β-defensin expression in Candida esophagitis.
American journal of physiology. Gastrointestinal and liver physiology 2011;300(4):G547-53.
2011: Rainer Noth; Philip Rosenstiel; Stefan Schreiber; Eckhard Stüber; Burkhard Bewig; Mark Ellrichmann; Jochen Hampe; Robert Häsler; Marie-Luise Kruse; Julia Lange-Grumfeld; Alexander Arlt
Increased intestinal permeability and tight junction disruption by altered expression and localization of occludin in a murine graft versus host disease model.
BMC gastroenterology 2011;11():109.
2010: Stephan Buch; Clemens Schafmayer; Henry Völzke; Markus Seeger; Juan Miquel; Silvia C Sookoian; Jan-Hendrik Egberts; Alexander Arlt; Carlos J Pirola; Markus M Lerch; Ulrich John; Andre Franke; Oliver von Kampen; Mario Brosch; Michael Nothnagel; Wolfgang Kratzer; Bernhard O Boehm; Dieter C Bröring; Stefan Schreiber; Michael Krawczak; Jochen Hampe
Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition.
Gastroenterology 2010;139(6):1942-1951.e2.
2010: Marcus Seeger; Rainer Günther; Holger Hinrichsen; Marcus Both; Ulf Helwig; Alexander Arlt; Birte Stelck; Jan H Bräsen; Bence Sipos; Clemens Schafmayer; Felix Braun; Dieter C Bröring; Stefan Schreiber; Jochen Hampe
Chronic portal vein thrombosis: transcapsular hepatic collateral vessels and communicating ectopic varices.
Radiology 2010;257(2):568-78.
2010: Arne S Schaefer; Gesa M Richter; Michael Nothnagel; Thomas Manke; Henrik Dommisch; Gunnar Jacobs; Alexander Arlt; Philip Rosenstiel; Barbara Noack; Birte Groessner-Schreiber; Søren Jepsen; Bruno G Loos; Stefan Schreiber
A genome-wide association study identifies GLT6D1 as a susceptibility locus for periodontitis.
Human molecular genetics 2010;19(3):553-62.
2009: Alexander Arlt; I Bauer; Clemens Schafmayer; Juergen Tepel; Susanne Müerköster; Mario Brosch; Christian Röder; Holger Kalthoff; Jochen Hampe; Mary Pat Moyer; Ulrich R Fölsch; Heiner Schäfer
Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2).
Oncogene 2009;28(45):3983-96.
2009: Simone Lipinski; Andreas Till; Christian Sina; Alexander Arlt; Helmut Grasberger; Stefan Schreiber; Philip Rosenstiel
DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses.
Journal of cell science 2009;122(Pt 19):3522-30.
2009: Almut Nebel; Friederike Flachsbart; Andreas Till; Amke Caliebe; Hélène Blanché; Alexander Arlt; Robert Häsler; Gunnar Jacobs; Rabea Kleindorp; Andre Franke; Binghui Shen; Susanna Nikolaus; Michael Krawczak; Philip Rosenstiel; Stefan Schreiber
A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians.
Mechanisms of ageing and development 2009;130(10):691-9.
2009: Nadine Steubesand; Karlheinz Kiehne; Gabriele Brunke; Rene Pahl; Karina Reiss; Karl-Heinz Herzig; Sabine Schubert; Stefan Schreiber; Ulrich R Fölsch; Philip Rosenstiel; Alexander Arlt
The expression of the beta-defensins hBD-2 and hBD-3 is differentially regulated by NF-kappaB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis.
BMC immunology 2009;10():36.
2008: Nour Eddine El Mokhtari; Alexander Arlt; A Meissner; Markus Lins
Inotropic therapy for cardiac low output syndrome: comparison of hemodynamic effects of dopamine/dobutamine versus dopamine/dopexamine.
European journal of medical research 2008;13(10):459-63.
2008: Alexander Arlt; B Harbeck; Martin Anlauf; I Alkatout; Günter Klöppel; Ulrich R Fölsch; Burkhard Bewig; Heiner Mönig
Fatal pneumocystis jirovecii pneumonia in a case of ectopic Cushing's syndrome due to neuroendocrine carcinoma of the kidney.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2008;116(9):515-9.
2008: Alexander Arlt; Philip Rosenstiel; Marie-Luise Kruse; Frauke Grohmann; Jörg Minkenberg; Neil D Perkins; Ulrich R Fölsch; Stefan Schreiber; Heiner Schäfer
IEX-1 directly interferes with RelA/p65 dependent transactivation and regulation of apoptosis.
Biochimica et biophysica acta 2008;1783(5):941-52.
2008: S Sebens Müerköster; A V Rausch; A Isberner; Jörg Minkenberg; E Blaszczuk; Maike Witt; Ulrich R Fölsch; F Schmitz; Heiner Schäfer; Alexander Arlt
The apoptosis-inducing effect of gastrin on colorectal cancer cells relates to an increased IEX-1 expression mediating NF-kappa B inhibition.
Oncogene 2008;27(8):1122-34.
2007: Alexander Arlt; Jörg Minkenberg; Marie-Luise Kruse; Frauke Grohmann; Ulrich R Fölsch; Heiner Schäfer
Immediate early gene-X1 interferes with 26 S proteasome activity by attenuating expression of the 19 S proteasomal components S5a/Rpn10 and S1/Rpn2.
The Biochemical journal 2007;402(2):367-75.
2006: Susanne Müerköster; J Lust; Alexander Arlt; R Häsler; Maike Witt; T Sebens; S Schreiber; Ulrich R Fölsch; Heiner Schäfer
Acquired chemoresistance in pancreatic carcinoma cells: induced secretion of IL-1beta and NO lead to inactivation of caspases.
Oncogene 2006;25(28):3973-81.
2006: Juergen Tepel; Christina March; Thomas Ketterer; Matthias Kapischke; Alexander Arlt; Bernd Kremer; Holger Kalthoff; Marie-Luise Kruse
A modified random oligonucleotide-based combination therapy for adjuvant treatment of pancreatic ductal adenocarcinoma.
International journal of oncology 2006;28(5):1105-12.
2005: Susanne Müerköster; Anett Isberner; Alexander Arlt; Maike Witt; Babette Reimann; Ewelina Blaszczuk; Veronika Werbing; Ulrich R Fölsch; Frank Schmitz; Heiner Schäfer
Gastrin suppresses growth of CCK2 receptor expressing colon cancer cells by inducing apoptosis in vitro and in vivo.
Gastroenterology 2005;129(3):952-68.
2005: Marie-Luise Kruse; Alexander Arlt; Alexander Sieke; Frauke Grohmann; Maike Grossmann; Jörg Minkenberg; Ulrich R Fölsch; Heiner Schäfer
Immediate early gene X1 (IEX-1) is organized in subnuclear structures and partially co-localizes with promyelocytic leukemia protein in HeLa cells.
The Journal of biological chemistry 2005;280(26):24849-56.
2005: Anna Trauzold; Christian Röder; Bence Sipos; Kristin Karsten; Alexander Arlt; Ping Jiang; Jose I Martin-Subero; Daniela Siegmund; Susanne Müerköster; Laia Pagerols-Raluy; Reiner Siebert; Harald Wajant; Holger Kalthoff
CD95 and TRAF2 promote invasiveness of pancreatic cancer cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(6):620-2.
2005: Susanne Müerköster; Alexander Arlt; Bence Sipos; Maike Witt; Maike Grossmann; Günter Klöppel; Holger Kalthoff; Ulrich R Fölsch; Heiner Schäfer
Increased expression of the E3-ubiquitin ligase receptor subunit betaTRCP1 relates to constitutive nuclear factor-kappaB activation and chemoresistance in pancreatic carcinoma cells.
Cancer research 2005;65(4):1316-24.
2005: Georg H Waetzig; Philip Rosenstiel; Alexander Arlt; Andreas Till; Karen Bräutigam; Heiner Schäfer; Stefan Rose-John; Dirk Seegert; Stefan Schreiber
Soluble tumor necrosis factor (TNF) receptor-1 induces apoptosis via reverse TNF signaling and autocrine transforming growth factor-beta1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(1):91-3.
2004: Alexander Arlt; Jörg Minkenberg; B Kocs; Maike Grossmann; Marie-Luise Kruse; Ulrich R Fölsch; Heiner Schäfer
The expression of immediate early gene X-1 (IEX-1) is differentially induced by retinoic acids in NB4 and KG1 cells: possible implication in the distinct phenotype of retinoic acid-responsive and -resistant leukemic cells.
Leukemia 2004;18(10):1646-55.
2004: Susanne Müerköster; Alexander Arlt; André Gehrz; Jens Vorndamm; Maike Witt; Frauke Grohmann; Ulrich R Fölsch; Heiner Schäfer
[Autocrine IL-1beta secretion leads to NF-kappabeta-mediated chemoresistance in pancreatic carcinoma cells in vivo].
Medizinische Klinik (Munich, Germany : 1983) 2004;99(4):185-90.
2004: Susanne Müerköster; Kai Wegehenkel; Alexander Arlt; Maike Witt; Bence Sipos; Marie-Luise Kruse; Thorsten Sebens; Günter Klöppel; Holger Kalthoff; Ulrich R Fölsch; Heiner Schäfer
Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta.
Cancer research 2004;64(4):1331-7.
2003: Anna Trauzold; Stefan Schmiedel; Bence Sipos; Hendrik Wermann; Sabine Westphal; Christian Röder; Wolfram Klapper; Alexander Arlt; Lasse Lehnert; Hendrik Ungefroren; Franz-Josef Johannes; Holger Kalthoff
PKCmu prevents CD95-mediated apoptosis and enhances proliferation in pancreatic tumour cells.
Oncogene 2003;22(55):8939-47.
2003: Anna Trauzold; Stefan Schmiedel; Christian Röder; C Tams; Matthias Christgen; Stefanie Oestern; Alexander Arlt; Sabine Westphal; Matthias Kapischke; Hendrik Ungefroren; Holger Kalthoff
Multiple and synergistic deregulations of apoptosis-controlling genes in pancreatic carcinoma cells.
British journal of cancer 2003;89(9):1714-21.
2003: Alexander Arlt; Marie-Luise Kruse; Maike Breitenbroich; André Gehrz; Bülent Koc; Jörg Minkenberg; Ulrich R Fölsch; Heiner Schäfer
The early response gene IEX-1 attenuates NF-kappaB activation in 293 cells, a possible counter-regulatory process leading to enhanced cell death.
Oncogene 2003;22(21):3343-51.
2003: Alexander Arlt; André Gehrz; Susanne Müerköster; Jens Vorndamm; Marie-Luise Kruse; Ulrich R Fölsch; Heiner Schäfer
Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death.
Oncogene 2003;22(21):3243-51.
2003: Susanne Müerköster; Alexander Arlt; Maike Witt; André Gehrz; Sieglinde Haye; Christina March; Frauke Grohmann; Kai Wegehenkel; Holger Kalthoff; Ulrich R Fölsch; Heiner Schäfer
Usage of the NF-kappaB inhibitor sulfasalazine as sensitizing agent in combined chemotherapy of pancreatic cancer.
International journal of cancer. Journal international du cancer 2003;104(4):469-76.
2002: Alexander Arlt; Heiner Schäfer
NFkappaB-dependent chemoresistance in solid tumors.
International journal of clinical pharmacology and therapeutics 2002;40(8):336-47.
2002: H Schiller; T Bartscht; Alexander Arlt; M O Zahn; A Seifert; Thomas Bruhn; Hans Dietrich Bruhn; Frank Gieseler
Thrombin as a survival factor for cancer cells: thrombin activation in malignant effusions in vivo and inhibition of idarubicin-induced cell death in vitro.
International journal of clinical pharmacology and therapeutics 2002;40(8):329-35.
2002: Alexander Arlt; Jens Vorndamm; Susanne Müerköster; Honggang Yu; Wolfgang E Schmidt; Ulrich R Fölsch; Heiner Schäfer
Autocrine production of interleukin 1beta confers constitutive nuclear factor kappaB activity and chemoresistance in pancreatic carcinoma cell lines.
Cancer research 2002;62(3):910-6.
2002: Philip Rosenstiel; Stefan Gallinat; Alexander Arlt; Thomas Unger; Jobst Sievers; Ralph Lucius
Angiotensin AT2 receptor ligands: do they have potential as future treatments for neurological disease?
CNS drugs 2002;16(3):145-53.
2001: Hendrik Ungefroren; Marie-Luise Kruse; Anna Trauzold; S Roeschmann; C Roeder; Alexander Arlt; Doris Henne-Bruns; Holger Kalthoff
FAP-1 in pancreatic cancer cells: functional and mechanistic studies on its inhibitory role in CD95-mediated apoptosis.
Journal of cell science 2001;114(Pt 15):2735-46.
2001: Anna Trauzold; H Wermann; Alexander Arlt; Stefan Schütze; Heiner Schäfer; Stefanie Oestern; Christian Röder; Hendrik Ungefroren; E Lampe; Michael Heinrich; H Walczak; Holger Kalthoff
CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells.
Oncogene 2001;20(31):4258-69.
2001: O Grobe; Alexander Arlt; Hendrik Ungefroren; Guido Krupp; Ulrich R Fölsch; Wolfgang E Schmidt; Heiner Schäfer
Functional disruption of IEX-1 expression by concatemeric hammerhead ribozymes alters growth properties of 293 cells.
FEBS letters 2001;494(3):196-200.
2001: Alexander Arlt; Jens Vorndamm; M Breitenbroich; Ulrich R Fölsch; Holger Kalthoff; Wolfgang E Schmidt; Heiner Schäfer
Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin.
Oncogene 2001;20(7):859-68.
2001: Alexander Arlt; O Grobe; A Sieke; Marie-Luise Kruse; Ulrich R Fölsch; Wolfgang E Schmidt; Heiner Schäfer
Expression of the NF-kappa B target gene IEX-1 (p22/PRG1) does not prevent cell death but instead triggers apoptosis in Hela cells.
Oncogene 2001;20(1):69-76.
1999: Heiner Schäfer; Alexander Arlt; Anna Trauzold; A Hünermann-Jansen; Wolfgang E Schmidt
The putative apoptosis inhibitor IEX-1L is a mutant nonspliced variant of p22(PRG1/IEX-1) and is not expressed in vivo.
Biochemical and biophysical research communications 1999;262(1):139-45.
1999: Wolfgang E Schmidt; Alexander Arlt; Anna Trauzold; Heiner Schäfer
p22/PRG1: a novel early response gene in pancreatic cancer cells regulated by p53 and NF kappa B.
Annals of the New York Academy of Sciences 1999;880():147-56.
1998: Heiner Schäfer; J Diebel; Alexander Arlt; Anna Trauzold; Wolfgang E Schmidt
The promoter of human p22/PACAP response gene 1 (PRG1) contains functional binding sites for the p53 tumor suppressor and for NFkappaB.
FEBS letters 1998;436(2):139-43.