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Volker Arlt

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Katerina Levova; Michaela Moserova; Daniel W Nebert; David H Phillips; Heinz H Schmeiser; Volker M Arlt; Eva Frei; Marie Stiborova
NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I.
Thomas E R Baudoux; Eric G De Prez; Jean-Michel Goujon; Marie-Hélène Antoine; Volker M Arlt; Agnieszka A Pozdzik; Nathalie Quellard; Joëlle L Nortier
Probenecid prevents acute tubular necrosis in a mouse model of aristolochic acid nephropathy.
Heinz H Schmeiser; Volker M Arlt; Liviu Daminescu; Cristina Gluhovschi; Gheorghe Gluhovschi; Monica Hollstein; Jill E Kucab; Mirela Modilca; Ligia Petrica; David H Phillips; Silvia Velciov
Evidence of exposure to aristolochic acid in patients with urothelial cancer from a Balkan endemic nephropathy region of Romania.

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2012: Katerina Levova; Michaela Moserova; Daniel W Nebert; David H Phillips; Heinz H Schmeiser; Volker M Arlt; Eva Frei; Marie Stiborova
NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I.
Toxicology and applied pharmacology 2012;265(3):360-7.
2012: Thomas E R Baudoux; Eric G De Prez; Jean-Michel Goujon; Marie-Hélène Antoine; Volker M Arlt; Agnieszka A Pozdzik; Nathalie Quellard; Joëlle L Nortier
Probenecid prevents acute tubular necrosis in a mouse model of aristolochic acid nephropathy.
Kidney international 2012;82(10):1105-13.
2012: Heinz H Schmeiser; Volker M Arlt; Liviu Daminescu; Cristina Gluhovschi; Gheorghe Gluhovschi; Monica Hollstein; Jill E Kucab; Mirela Modilca; Ligia Petrica; David H Phillips; Silvia Velciov
Evidence of exposure to aristolochic acid in patients with urothelial cancer from a Balkan endemic nephropathy region of Romania.
Environmental and molecular mutagenesis 2012;53(8):636-41.
2012: Yiying Wang; David H Phillips; Candice Roufosse; Volker M Arlt; Karen L McKim; Meagan B Myers; Barbara L Parsons
ACB-PCR measurement of H-ras codon 61 CAA→CTA mutation provides an early indication of aristolochic acid I carcinogenic effect in tumor target tissues.
Environmental and molecular mutagenesis 2012;53(7):495-504.
2012: L Patrice McDaniel; Volker M Arlt; Tao Chen; Elizabeth R Elander; Xiaoqing Guo; Nan Mei
Mutagenicity and DNA adduct formation by aristolochic acid in the spleen of Big Blue® rats.
Environmental and molecular mutagenesis 2012;53(5):358-68.
2012: Jill E Kucab; David H Phillips; Volker M Arlt
Metabolic activation of diesel exhaust carcinogens in primary and immortalized human TP53 knock-in (Hupki) mouse embryo fibroblasts.
Environmental and molecular mutagenesis 2012;53(3):207-17.
2012: Marie Stiborová; Frantisek Bárta; Eva Frei; Katerina Levová; Daniel W Nebert; David H Phillips; Heinz H Schmeiser; Zhanquan Shi; Volker M Arlt
Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2.
Toxicological sciences : an official journal of the Society of Toxicology 2012;125(2):345-58.
2012: Marie Stiborova; Lucie Borek-Dohalska; Tereza Cechova; Eva Frei; Michaela Moserova; Jan Paca; Heinz H Schmeiser; Volker M Arlt
Activation and detoxification metabolism of urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone by rat and mouse hepatic microsomes.
Neuro endocrinology letters 2012;33 Suppl 3():8-15.
2011: Volker M Arlt; James D Evans; Peter B Farmer; Eva Frei; Gonçalo Gamboa da Costa; Colin J Henderson; Rajinder Singh; Marie Stiborová; C Roland Wolf; David H Phillips
Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA adduct formation in P450 reductase conditional null mice.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(12):2169-73.
2011: Elisabeth Oya; David H Phillips; Volker M Arlt; Eszter Nagy; Johan Ovrevik; Jørn Holme
DNA damage and DNA damage response in human bronchial epithelial BEAS-2B cells following exposure to 2-nitrobenzanthrone and 3-nitrobenzanthrone: role in apoptosis.
Mutagenesis 2011;26(6):697-708.
2011: Volker M Arlt; David H Phillips; Jóhannes Reynisson
Theoretical investigations on the formation of nitrobenzanthrone-DNA adducts.
Organic & biomolecular chemistry 2011;9(17):6100-10.
2011: Volker M Arlt; Tanja Schwerdtle
UKEMS/Dutch EMS-sponsored workshop on biomarkers of exposure and oxidative DNA damage & 7th GUM-32P-postlabelling workshop, University of Münster, Münster, Germany, 28-29 March 2011.
Mutagenesis 2011;26(5):679-85.
2011: Yiying Wang; Volker M Arlt; Tao Chen; Nan Mei; Fanxue Meng; Barbara L Parsons
Aristolochic acid-induced carcinogenesis examined by ACB-PCR quantification of H-Ras and K-Ras mutant fraction.
Mutagenesis 2011;26(5):619-28.
2011: Marie Stiborová; Volker M Arlt; Eva Frei; Jaroslav Mareîs; Václav Martínek; Heinz H Schmeiser
The human carcinogen aristolochic acid i is activated to form DNA adducts by human NAD(P)H:quinone oxidoreductase without the contribution of acetyltransferases or sulfotransferases.
Environmental and molecular mutagenesis 2011;52(6):448-59.
2011: Katerina Levová; Michaela Moserová; Vera Kotrbová; Miroslav Sulc; Colin Henderson; C Roland Wolf; David H Phillips; Eva Frei; Heinz H Schmeiser; Jaroslav Mares; Volker M Arlt; Marie Stiborová
Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.
Toxicological sciences : an official journal of the Society of Toxicology 2011;121(1):43-56.
2011: Jana Mizerovská; Helena Dračínská; Eva Frei; Heinz H Schmeiser; Volker M Arlt; Marie Stiborová
Induction of biotransformation enzymes by the carcinogenic air-pollutant 3-nitrobenzanthrone in liver, kidney and lung, after intra-tracheal instillation in rats.
Mutation research 2011;720(1-2):34-41.
2011: Petr Hodek; Jitka Krizkova; Rajinder Singh; Volker M Arlt; Eva Frei; Marie Stiborova
Impact of beta-naphthoflavone on genotoxicity of food-derived carcinogens.
Neuro endocrinology letters 2011;32 Suppl 1():25-34.
2011: Vaclav Martinek; Heinz H Schmeiser; Volker M Arlt; Eva Frei; Jirí Hudecek; Bozena Kubickova; Marie Stiborova
Comparison of activation of aristolochic acid I and II with NADPH:quinone oxidoreductase, sulphotransferases and N-acetyltranferases.
Neuro endocrinology letters 2011;32 Suppl 1():57-70.
2011: Hamza Hamouchene; Volker M Arlt; Ian Giddings; David H Phillips
Influence of cell cycle on responses of MCF-7 cells to benzo[a]pyrene.
BMC genomics 2011;12():333.
2011: Volker M Arlt; Jie Zuo; Kristina Trenz; Candice A Roufosse; Graham M Lord; Joelle L Nortier; Heinz H Schmeiser; Monica Hollstein; David H Phillips
Gene expression changes induced by the human carcinogen aristolochic acid I in renal and hepatic tissue of mice.
International journal of cancer. Journal international du cancer 2011;128(1):21-32.
2010: Marie Stiborová; Václav Martínek; Martina Svobodová; Jana Sístková; Zdenek Dvorák; Jitka Ulrichová; Vilím Simánek; Eva Frei; Heinz H Schmeiser; David H Phillips; Volker M Arlt
Mechanisms of the different DNA adduct forming potentials of the urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone.
Chemical research in toxicology 2010;23(7):1192-201.
2010: Jill E Kucab; David H Phillips; Volker M Arlt
Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model.
The FEBS journal 2010;277(12):2567-83.
2010: N E Landvik; Volker M Arlt; E Nagy; Anita Solhaug; Xavier Tekpli; H H Schmeiser; M Refsnes; David H Phillips; D Lagadic-Gossmann; Jørn Holme
3-Nitrobenzanthrone and 3-aminobenzanthrone induce DNA damage and cell signalling in Hepa1c1c7 cells.
Mutation research 2010;684(1-2):11-23.
2010: Johan Ovrevik; Volker M Arlt; E Oya; E Nagy; Steen Mollerup; David H Phillips; Marit Låg; Jørn Holme
Differential effects of nitro-PAHs and amino-PAHs on cytokine and chemokine responses in human bronchial epithelial BEAS-2B cells.
Toxicology and applied pharmacology 2010;242(3):270-80.
2009: Gonçalo Gamboa da Costa; Rajinder Singh; Volker M Arlt; Amin Mirza; Meirion Richards; Takeji Takamura-Enya; Heinz H Schmeiser; Peter B Farmer; David H Phillips
Quantification of 3-nitrobenzanthrone-DNA adducts using online column-switching HPLC-electrospray tandem mass spectrometry.
Chemical research in toxicology 2009;22(11):1860-8.
2009: Heinz H Schmeiser; Gerhard Fürstenberger; Takeji Takamura-Enya; David H Phillips; Volker M Arlt
The genotoxic air pollutant 3-nitrobenzanthrone and its reactive metabolite N-hydroxy-3-aminobenzanthrone lack initiating and complete carcinogenic activity in NMRI mouse skin.
Cancer letters 2009;284(1):21-9.
2009: Marie Stiborová; Helena Dracínská; Markéta Martínková; Jana Mizerovská; Jirí Hudecek; Petr Hodek; Jirí Liberda; Eva Frei; Heinz H Schmeiser; David H Phillips; Volker M Arlt
3-aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone, induces biotransformation enzymes in rat kidney and lung.
Mutation research 2009;676(1-2):93-101.
2009: Marie Stiborova; Eva Frei; Volker M Arlt; Heinz H Schmeiser
The role of biotransformation enzymes in the development of renal injury and urothelial cancer caused by aristolochic acid: urgent questions and difficult answers.
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2009;153(1):5-11.
2009: Jana Mizerovska; Helena Dracinska; Volker M Arlt; Heinz H Schmeiser; Eva Frei; Marie Stiborova
Oxidation of 3-aminobenzanthrone, a human metabolite of carcinogenic environmental pollutant 3-nitrobenzanthrone, by cytochromes P450 - similarity between human and rat enzymes.
Neuro endocrinology letters 2009;30 Suppl 1():52-9.
2009: David H Phillips; Volker M Arlt
Genotoxicity: damage to DNA and its consequences.
EXS 2009;99():87-110.
2009: Heinz H Schmeiser; Marie Stiborovà; Volker M Arlt
Chemical and molecular basis of the carcinogenicity of Aristolochia plants.
Current opinion in drug discovery & development 2009;12(1):141-8.
2008: Volker M Arlt; John Gingerich; Heinz H Schmeiser; David H Phillips; George R Douglas; Paul A White
Genotoxicity of 3-nitrobenzanthrone and 3-aminobenzanthrone in MutaMouse and lung epithelial cells derived from MutaMouse.
Mutagenesis 2008;23(6):483-90.
2008: Maria L Simões; Sarah L Hockley; Tanja Schwerdtle; Gonçalo Gamboa da Costa; Heinz H Schmeiser; David H Phillips; Volker M Arlt
Gene expression profiles modulated by the human carcinogen aristolochic acid I in human cancer cells and their dependence on TP53.
Toxicology and applied pharmacology 2008;232(1):86-98.
2008: Jóhannes Reynisson; Marie Stiborová; Václav Martínek; Gonçalo Gamboa da Costa; David H Phillips; Volker M Arlt
Mutagenic potential of nitrenium ions of nitrobenzanthrones: correlation between theory and experiment.
Environmental and molecular mutagenesis 2008;49(8):659-67.
2008: Dagmar Aimová; Jitka Poljaková; Vera Kotrbová; Michaela Moserová; Eva Frei; Volker M Arlt; Marie Stiborová
Ellipticine and benzo(a)pyrene increase their own metabolic activation via modulation of expression and enzymatic activity of cytochromes P450 1A1 and 1A2.
Interdisciplinary toxicology 2008;1(2):160-8.
2008: Jana Mizerovská; Helena Dračínská; Volker M Arlt; Jiří Hudeček; Petr Hodek; Heinz H Schmeiser; Eva Frei; Marie Stiborová
Rat cytochromes P450 oxidize 3-aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone.
Interdisciplinary toxicology 2008;1(2):150-4.
2008: Lauren A Courter; Andreas Luch; Tamara Musafia-Jeknic; Volker M Arlt; Kay Fischer; Robert J Bildfell; Cliff Pereira; David H Phillips; Miriam C Poirier; William M Baird
The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivo.
Cancer letters 2008;265(1):135-47.
2008: Marie Stiborová; Helena Dracínská; Jana Mizerovská; Eva Frei; Heinz H Schmeiser; Jirí Hudecek; Petr Hodek; David H Phillips; Volker M Arlt
The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity.
Toxicology 2008;247(1):11-22.
2008: Volker M Arlt; Marie Stiborová; Colin Henderson; Markus Thiemann; Eva Frei; Dagmar Aimová; Rajinder Singh; Gonçalo Gamboa da Costa; Oliver J Schmitz; Peter B Farmer; C Roland Wolf; David H Phillips
Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.
Carcinogenesis 2008;29(3):656-65.
2008: Marie Stiborová; Volker M Arlt; Colin Henderson; C Roland Wolf; Vera Kotrbová; Michaela Moserová; Jirí Hudecek; David H Phillips; Eva Frei
Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: studies with the hepatic NADPH:cytochrome P450 reductase null mouse.
Toxicology and applied pharmacology 2008;226(3):318-27.
2008: Sarah L Hockley; Volker M Arlt; Gunnar Jahnke; Andrea Hartwig; Ian Giddings; David H Phillips
Identification through microarray gene expression analysis of cellular responses to benzo(a)pyrene and its diol-epoxide that are dependent or independent of p53.
Carcinogenesis 2008;29(1):202-10.
2008: Marie Stiborová; Eva Frei; Volker M Arlt; Heinz H Schmeiser
Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy.
Mutation research 2008;658(1-2):55-67.
2007: Sarah L Hockley; Volker M Arlt; Daniel Brewer; Robert te Poele; Paul Workman; Ian Giddings; David H Phillips
AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines.
Chemical research in toxicology 2007;20(12):1797-810.
2007: Takaharu Kanno; Masanobu Kawanishi; Takeji Takamura-Enya; Volker M Arlt; David H Phillips; Takashi Yagi
DNA adduct formation in human hepatoma cells treated with 3-nitrobenzanthrone: analysis by the (32)P-postlabeling method.
Mutation research 2007;634(1-2):184-91.
2007: Volker M Arlt; Marie Stiborová; Jochen Vom Brocke; Maria L Simões; Graham M Lord; Joelle L Nortier; Monica Hollstein; David H Phillips; Heinz H Schmeiser
Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer.
Carcinogenesis 2007;28(11):2253-61.
2007: Volker M Arlt; Hansruedi Glatt; Gonçalo Gamboa da Costa; Jóhannes Reynisson; Takeji Takamura-Enya; David H Phillips
Mutagenicity and DNA adduct formation by the urban air pollutant 2-nitrobenzanthrone.
Toxicological sciences : an official journal of the Society of Toxicology 2007;98(2):445-57.
2007: Christian A Bieler; Michael G Cornelius; Marie Stiborova; Volker M Arlt; Manfred Wiessler; David H Phillips; Heinz H Schmeiser
Formation and persistence of DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in target and non-target organs after intratracheal instillation in rats.
Carcinogenesis 2007;28(5):1117-21.
2007: Jørn Holme; Morgane Gorria; Volker M Arlt; Steinar Øvrebø; Anita Solhaug; Xavier Tekpli; Nina E Landvik; Laurence Huc; Olivier Fardel; Dominique Lagadic-Gossmann
Different mechanisms involved in apoptosis following exposure to benzo[a]pyrene in F258 and Hepa1c1c7 cells.
Chemico-biological interactions 2007;167(1):41-55.
2007: Nina E Landvik; Morgane Gorria; Volker M Arlt; Nana Asare; Anita Solhaug; Dominique Lagadic-Gossmann; Jørn Holme
Effects of nitrated-polycyclic aromatic hydrocarbons and diesel exhaust particle extracts on cell signalling related to apoptosis: possible implications for their mutagenic and carcinogenic effects.
Toxicology 2007;231(2-3):159-74.
2007: David H Phillips; Volker M Arlt
The 32P-postlabeling assay for DNA adducts.
Nature protocols 2007;2(11):2772-81.
2007: Volker M Arlt; Eva Frei; Heinz H Schmeiser
ECNIS-sponsored workshop on biomarkers of exposure and cancer risk: DNA damage and DNA adduct detection and 6th GUM-32P-postlabelling workshop, German Cancer Research Center, Heidelberg, Germany, 29-30 September 2006.
Mutagenesis 2007;22(1):83-8.
2006: Nan Mei; Volker M Arlt; David H Phillips; Robert H Heflich; Tao Chen
DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liver.
Mutation research 2006;602(1-2):83-91.
2006: Marie Stiborová; Helena Dracínská; Jana Hájková; Pavla Kaderábková; Eva Frei; Heinz H Schmeiser; Pavel Soucek; David H Phillips; Volker M Arlt
The environmental pollutant and carcinogen 3-nitrobenzanthrone and its human metabolite 3-aminobenzanthrone are potent inducers of rat hepatic cytochromes P450 1A1 and -1A2 and NAD(P)H:quinone oxidoreductase.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(8):1398-405.
2006: Volker M Arlt; Heinz H Schmeiser; Martin R Osborne; Masanobu Kawanishi; Takaharu Kanno; Takashi Yagi; David H Phillips; Takeji Takamura-Enya
Identification of three major DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in rat lung at the C8 and N2 position of guanine and at the N6 position of adenine.
International journal of cancer. Journal international du cancer 2006;118(9):2139-46.
2006: Volker M Arlt; Colin Henderson; C Roland Wolf; Heinz H Schmeiser; David H Phillips; Marie Stiborova
Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases.
Cancer letters 2006;234(2):220-31.
2006: Sarah L Hockley; Volker M Arlt; Daniel Brewer; Ian Giddings; David H Phillips
Time- and concentration-dependent changes in gene expression induced by benzo(a)pyrene in two human cell lines, MCF-7 and HepG2.
BMC genomics 2006;7():260.
2005: Marie Stiborová; Volker M Arlt; Colin Henderson; C Roland Wolf; Eva Frei; Heinz H Schmeiser; David H Phillips
Molecular mechanism of genotoxicity of the environmental pollutant 3-nitrobenzanthrone.
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2005;149(2):191-7.
2005: Volker M Arlt
3-Nitrobenzanthrone, a potential human cancer hazard in diesel exhaust and urban air pollution: a review of the evidence.
Mutagenesis 2005;20(6):399-410.
2005: Catherine Lebeau; Frederic Debelle; Volker M Arlt; Agnieszka Pozdzik; Eric G De Prez; David H Phillips; Monique M Deschodt-Lanckman; Jean-Louis Vanherweghem; Joëlle L Nortier
Early proximal tubule injury in experimental aristolochic acid nephropathy: functional and histological studies.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2005;20(11):2321-32.
2005: Christian A Bieler; Michael G Cornelius; Reinhold Klein; Volker M Arlt; Manfred Wiessler; David H Phillips; Heinz H Schmeiser
DNA adduct formation by the environmental contaminant 3-nitrobenzanthrone after intratracheal instillation in rats.
International journal of cancer. Journal international du cancer 2005;116(6):833-8.
2005: David H Phillips; Alan Hewer; Martin R Osborne; Kathleen J Cole; Cyd Churchill; Volker M Arlt
Organ specificity of DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen in the rat: implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment.
Mutagenesis 2005;20(4):297-303.
2005: Martin R Osborne; Volker M Arlt; Christian Kliem; William E Hull; Amin Mirza; Christian A Bieler; Heinz H Schmeiser; David H Phillips
Synthesis, characterization, and 32p-postlabeling analysis of DNA adducts derived from the environmental contaminant 3-nitrobenzanthrone.
Chemical research in toxicology 2005;18(6):1056-70.
2005: Volker M Arlt; Marie Stiborova; Colin Henderson; Martin R Osborne; Christian A Bieler; Eva Frei; Vaclav Martinek; Bruno Sopko; C Roland Wolf; Heinz H Schmeiser; David H Phillips
Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols.
Cancer research 2005;65(7):2644-52.
2005: Stanley H Lo; Kin-shing Wong; Volker M Arlt; David H Phillips; Chi-Kong Lai; Wing-Tat Poon; Ching-Kit Chan; Ka-Leung Mo; Kwok Wah Chan; Albert Chan
Detection of Herba Aristolochia Mollissemae in a patient with unexplained nephropathy.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2005;45(2):407-10.
2005: David H Phillips; Alan Hewer; Volker M Arlt
32P-postlabeling analysis of DNA adducts.
Methods in molecular biology (Clifton, N.J.) 2005;291():3-12.
2004: Volker M Arlt; Véronique Alunni-Perret; Gérald Quatrehomme; Patrick Ohayon; Laetitia Albano; Hacène Gaïd; Jean-Francois Michiels; Alain Meyrier; Elisabeth Cassuto; Manfred Wiessler; Heinz H Schmeiser; Jean-Pierre Cosyns
Aristolochic acid (AA)-DNA adduct as marker of AA exposure and risk factor for AA nephropathy-associated cancer.
International journal of cancer. Journal international du cancer 2004;111(6):977-80.
2004: Volker M Arlt; Alan Hewer; Bernd L Sorg; Heinz H Schmeiser; David H Phillips; Marie Stiborova
3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone, forms DNA adducts after metabolic activation by human and rat liver microsomes: evidence for activation by cytochrome P450 1A1 and P450 1A2.
Chemical research in toxicology 2004;17(8):1092-101.
2004: Graham M Lord; Monica Hollstein; Volker M Arlt; Candice Roufosse; Charles D Pusey; Terry Cook; Heinz H Schmeiser
DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathy.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2004;43(4):e11-7.
2004: Volker M Arlt; Kathleen J Cole; David H Phillips
Activation of 3-nitrobenzanthrone and its metabolites to DNA-damaging species in human B lymphoblastoid MCL-5 cells.
Mutagenesis 2004;19(2):149-56.
2004: Volker M Arlt; Li Zhan; Heinz H Schmeiser; Masamitsu Honma; Makoto Hayashi; David H Phillips; Takayoshi Suzuki
DNA adducts and mutagenic specificity of the ubiquitous environmental pollutant 3-nitrobenzanthrone in Muta Mouse.
Environmental and molecular mutagenesis 2004;43(3):186-95.
2003: Gaëlle Gillerot; Eric Goffin; Pierre Moulin; Volker M Arlt; David H Phillips; Jean-Pierre Cosyns; Olivier Devuyst
Aristolochic acid nephropathy and the peritoneum: Functional, structural, and molecular studies.
Kidney international 2003;64(5):1883-92.
2003: Christian A Bieler; Volker M Arlt; Manfred Wiessler; Heinz H Schmeiser
DNA adduct formation by the environmental contaminant 3-nitrobenzanthrone in V79 cells expressing human cytochrome P450 enzymes.
Cancer letters 2003;200(1):9-18.
2003: Volker M Arlt; Hansruedi Glatt; Eva Muckel; Ulrike Pabel; Bernd L Sorg; Albrecht Seidel; Heinz Frank; Heinz H Schmeiser; David H Phillips
Activation of 3-nitrobenzanthrone and its metabolites by human acetyltransferases, sulfotransferases and cytochrome P450 expressed in Chinese hamster V79 cells.
International journal of cancer. Journal international du cancer 2003;105(5):583-92.
2003: Volker M Arlt; Marie Stiborova; Alan Hewer; Heinz H Schmeiser; David H Phillips
Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome p450 reductase.
Cancer research 2003;63(11):2752-61.
2003: Frederic Debelle; Joëlle L Nortier; Volker M Arlt; Eric G De Prez; Anne R Vienne; Isabelle Salmon; David H Phillips; Monique M Deschodt-Lanckman; Jean-Louis Vanherweghem
Effects of dexfenfluramine on aristolochic acid nephrotoxicity in a rat model for Chinese-herb nephropathy.
Archives of toxicology 2003;77(4):218-26.
2003: Joëlle L Nortier; Heinz H Schmeiser; Marie-Carmen Muniz Martinez; Volker M Arlt; Catherine Vervaet; Christian Hubert Garbar; Philippe Daelemans; Jean-Louis Vanherweghem
Invasive urothelial carcinoma after exposure to Chinese herbal medicine containing aristolochic acid may occur without severe renal failure.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2003;18(2):426-8.
2003: Volker M Arlt; Bernd L Sorg; Martin Osborne; Alan Hewer; Albrecht Seidel; Heinz H Schmeiser; David H Phillips
DNA adduct formation by the ubiquitous environmental pollutant 3-nitrobenzanthrone and its metabolites in rats.
Biochemical and biophysical research communications 2003;300(1):107-14.
2002: Volker M Arlt; Hansruedi Glatt; Eva Muckel; Ulrike Pabel; Bernd L Sorg; Heinz H Schmeiser; David H Phillips
Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferase.
Carcinogenesis 2002;23(11):1937-45.
2002: Volker M Arlt; Dusan Ferluga; Marie Stiborova; Annie Pfohl-Leszkowicz; Mato Vukelic; Stjepan Ceovic; Heinz H Schmeiser; Jean-Pierre Cosyns
Is aristolochic acid a risk factor for Balkan endemic nephropathy-associated urothelial cancer?
International journal of cancer. Journal international du cancer 2002;101(5):500-2.
2002: Eva Frei; Christian A Bieler; Volker M Arlt; Manfred Wiessler; Marie Stiborová
Covalent binding of the anticancer drug ellipticine to DNA in V79 cells transfected with human cytochrome P450 enzymes.
Biochemical pharmacology 2002;64(2):289-95.
2002: Volker M Arlt; Marie Stiborova; Heinz H Schmeiser
Aristolochic acid as a probable human cancer hazard in herbal remedies: a review.
Mutagenesis 2002;17(4):265-77.
2001: Graham M Lord; T Cook; Volker M Arlt; Heinz H Schmeiser; G Williams; Charles D Pusey
Urothelial malignant disease and Chinese herbal nephropathy.
Lancet 2001;358(9292):1515-6.
2001: Gaëlle Gillerot; M Jadoul; Volker M Arlt; C van Ypersele de Strihou; Heinz H Schmeiser; P P But; Christian A Bieler; Jean-Pierre Cosyns
Aristolochic acid nephropathy in a Chinese patient: time to abandon the term "Chinese herbs nephropathy"?
American journal of kidney diseases : the official journal of the National Kidney Foundation 2001;38(5):E26.
2001: Catherine Lebeau; Volker M Arlt; Heinz H Schmeiser; Alain Boom; P J Verroust; Olivier Devuyst; Renaud Beauwens
Aristolochic acid impedes endocytosis and induces DNA adducts in proximal tubule cells.
Kidney international 2001;60(4):1332-42.
2001: Volker M Arlt; Christian A Bieler; Walter Mier; Manfred Wiessler; Heinz H Schmeiser
DNA adduct formation by the ubiquitous environmental contaminant 3-nitrobenzanthrone in rats determined by (32)P-postlabeling.
International journal of cancer. Journal international du cancer 2001;93(3):450-4.
2001: Volker M Arlt; Annie Pfohl-Leszkowicz; Jean-Pierre Cosyns; Heinz H Schmeiser
Analyses of DNA adducts formed by ochratoxin A and aristolochic acid in patients with Chinese herbs nephropathy.
Mutation research 2001;494(1-2):143-50.
2001: Volker M Arlt; Heinz H Schmeiser; G P Pfeifer
Sequence-specific detection of aristolochic acid-DNA adducts in the human p53 gene by terminal transferase-dependent PCR.
Carcinogenesis 2001;22(1):133-40.
2000: Joëlle L Nortier; Marie-Carmen Muniz Martinez; Heinz H Schmeiser; Volker M Arlt; Christian A Bieler; M Petein; Michel Depierreux; Luc De Pauw; Daniel Abramowicz; Pierre Vereerstraeten; Jean-Louis Vanherweghem
Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi)
The New England journal of medicine 2000;342(23):1686-92.
2000: Volker M Arlt; Manfred Wiessler; Heinz H Schmeiser
Using polymerase arrest to detect DNA binding specificity of aristolochic acid in the mouse H-ras gene.
Carcinogenesis 2000;21(2):235-42.
1999: Sebastian Kevekordes; Volker Mersch-Sundermann; C M Burghaus; J Spielberger; Heinz H Schmeiser; Volker M Arlt; Hartmut Dunkelberg
SOS induction of selected naturally occurring substances in Escherichia coli (SOS chromotest).
Mutation research 1999;445(1):81-91.