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Gerald Grimsley

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Disorders

Protein Denaturation

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Thermodynamics

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TOP 3
Gerald R Grimsley; Richard L Thurlkill; Saul R Trevino; J Martin Scholtz
Determining the conformational stability of a protein from urea and thermal unfolding curves.
C Nick Pace; Hailong Fu; Katrina Lee Fryar; John Landua; Saul R Trevino; Bret A Shirley; Marsha McNutt Hendricks; Satoshi Iimura; Ketan Gajiwala; J Martin Scholtz; Gerald R Grimsley
Contribution of hydrophobic interactions to protein stability.
Hailong Fu; Gerald R Grimsley; J Martin Scholtz; C Nick Pace
Increasing protein stability: importance of DeltaC(p) and the denatured state.

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All Publications

2013: Gerald R Grimsley; Richard L Thurlkill; Saul R Trevino; J Martin Scholtz
Determining the conformational stability of a protein from urea and thermal unfolding curves.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2013;Chapter 28():Unit28.4.
2011: C Nick Pace; Hailong Fu; Katrina Lee Fryar; John Landua; Saul R Trevino; Bret A Shirley; Marsha McNutt Hendricks; Satoshi Iimura; Ketan Gajiwala; J Martin Scholtz; Gerald R Grimsley
Contribution of hydrophobic interactions to protein stability.
Journal of molecular biology 2011;408(3):514-28.
2010: Hailong Fu; Gerald R Grimsley; J Martin Scholtz; C Nick Pace
Increasing protein stability: importance of DeltaC(p) and the denatured state.
Protein science : a publication of the Protein Society 2010;19(5):1044-52.
2010: C Nick Pace; Beatrice M P Huyghues-Despointes; Hailong Fu; Kazufumi Takano; J Martin Scholtz; Gerald R Grimsley
Urea denatured state ensembles contain extensive secondary structure that is increased in hydrophobic proteins.
Protein science : a publication of the Protein Society 2010;19(5):929-43.
2009: Hailong Fu; Gerald R Grimsley; Abbas Razvi; J Martin Scholtz; C Nick Pace
Increasing protein stability by improving beta-turns.
Proteins 2009;77(3):491-8.
2009: C Nick Pace; Gerald R Grimsley; J Martin Scholtz
Protein ionizable groups: pK values and their contribution to protein stability and solubility.
The Journal of biological chemistry 2009;284(20):13285-9.
2009: J Martin Scholtz; Gerald R Grimsley; C Nick Pace
Solvent denaturation of proteins and interpretations of the m value.
Methods in enzymology 2009;466():549-65.
2009: Gerald R Grimsley; J Martin Scholtz; C Nick Pace
A summary of the measured pK values of the ionizable groups in folded proteins.
Protein science : a publication of the Protein Society 2009;18(1):247-51.
2008: Roy W Alston; Mauricio Lasagna; Gerald R Grimsley; J Martin Scholtz; Gregory D Reinhart; C Nick Pace
Peptide sequence and conformation strongly influence tryptophan fluorescence.
Biophysical journal 2008;94(6):2280-7.
2008: Roy W Alston; Mauricio Lasagna; Gerald R Grimsley; J Martin Scholtz; Gregory D Reinhart; C Nick Pace
Tryptophan fluorescence reveals the presence of long-range interactions in the denatured state of ribonuclease Sa.
Biophysical journal 2008;94(6):2288-96.
2006: Richard L Thurlkill; Gerald R Grimsley; J Martin Scholtz; C Nick Pace
Hydrogen bonding markedly reduces the pK of buried carboxyl groups in proteins.
Journal of molecular biology 2006;362(3):594-604.
2006: Richard L Thurlkill; Gerald R Grimsley; J Martin Scholtz; C Nick Pace
pK values of the ionizable groups of proteins.
Protein science : a publication of the Protein Society 2006;15(5):1214-8.
2006: Gerald R Grimsley; Beatrice M P Huyghues-Despointes; C Nick Pace; J Martin Scholtz
Measuring the conformational stability of a protein by NMR.
CSH protocols 2006;2006(1):.
2006: Gerald R Grimsley; Beatrice M P Huyghues-Despointes; C Nick Pace; J Martin Scholtz
Determining a thermal unfolding curve.
CSH protocols 2006;2006(1):.
2006: Gerald R Grimsley; Beatrice M P Huyghues-Despointes; C Nick Pace; J Martin Scholtz
Determining a urea or guanidinium chloride unfolding curve.
CSH protocols 2006;2006(1):.
2006: Gerald R Grimsley; Beatrice M P Huyghues-Despointes; C Nick Pace; J Martin Scholtz
Preparation of urea and guanidinium chloride stock solutions for measuring denaturant-induced unfolding curves.
CSH protocols 2006;2006(1):.
2004: Gerald R Grimsley; C Nick Pace
Spectrophotometric determination of protein concentration.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2004;Chapter 3():Unit 3.1.
2003: Douglas V Laurents; Beatrice M P Huyghues-Despointes; Marta Bruix; Richard L Thurlkill; David Schell; Stephanie Newsom; Gerald R Grimsley; Kevin L Shaw; Saul Treviño; Manuel Rico; James M Briggs; Jan M Antosiewicz; J Martin Scholtz; C Nick Pace
Charge-charge interactions are key determinants of the pK values of ionizable groups in ribonuclease Sa (pI=3.5) and a basic variant (pI=10.2).
Journal of molecular biology 2003;325(5):1077-92.
2002: C Nick Pace; Beatrice M P Huyghues-Despointes; James M Briggs; Gerald R Grimsley; J Martin Scholtz
Charge-charge interactions are the primary determinants of the pK values of the ionizable groups in Ribonuclease T1.
Biophysical chemistry 2002;101-102():211-9.
2001: Kevin L Shaw; Gerald R Grimsley; Gennady I Yakovlev; Alexander A Makarov; C Nick Pace
The effect of net charge on the solubility, activity, and stability of ribonuclease Sa.
Protein science : a publication of the Protein Society 2001;10(6):1206-15.
1999: Gerald R Grimsley; Kevin L Shaw; L R Fee; Roy W Alston; Beatrice M P Huyghues-Despointes; Richard L Thurlkill; J Martin Scholtz; C Nick Pace
Increasing protein stability by altering long-range coulombic interactions.
Protein science : a publication of the Protein Society 1999;8(9):1843-9.
1999: C Nick Pace; Gerald R Grimsley; Susan T Thomas; George I Makhatadze
Heat capacity change for ribonuclease A folding.
Protein science : a publication of the Protein Society 1999;8(7):1500-4.
1998: C Nick Pace; EJ Hebert; Kevin L Shaw; David Schell; V Both; Daniela Krajcikova; Jozef Sevcik; Keith S Wilson; Zbigniew Dauter; RW Hartley; Gerald R Grimsley
Conformational stability and thermodynamics of folding of ribonucleases Sa, Sa2 and Sa3.
Journal of molecular biology 1998;279(1):271-86.
1997: EJ Hebert; Gerald R Grimsley; RW Hartley; G Horn; David Schell; S Garcia; V Both; Jozef Sevcik; C Nick Pace
Purification of ribonucleases Sa, Sa2, and Sa3 after expression in Escherichia coli.
Protein expression and purification 1997;11(2):162-8.
1995: C Nick Pace; F Vajdos; L Fee; Gerald R Grimsley; T Gray
How to measure and predict the molar absorption coefficient of a protein.
Protein science : a publication of the Protein Society 1995;4(11):2411-23.
1989: J A Thomson; B A Shirley; Gerald R Grimsley; C Nick Pace
Conformational stability and mechanism of folding of ribonuclease T1.
The Journal of biological chemistry 1989;264(20):11614-20.
1988: C Nick Pace; Gerald R Grimsley; J A Thomson; B J Barnett
Conformational stability and activity of ribonuclease T1 with zero, one, and two intact disulfide bonds.
The Journal of biological chemistry 1988;263(24):11820-5.
1988: C Nick Pace; Gerald R Grimsley
Ribonuclease T1 is stabilized by cation and anion binding.
Biochemistry 1988;27(9):3242-6.
1987: C Nick Pace; Gerald R Grimsley; B J Barnett
Purification of ribonuclease T1.
Analytical biochemistry 1987;167(2):418-22.