FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Nigel Grindley

Research Profile

Chemicals & Drugs

Living Beings

Escherichia coli

Concepts & Ideas

Physiology

Co-author Network

Publications

TOP 3
Hua Bai; Pallavi Ghosh; Nigel D F Grindley; Graham F Hatfull; James E Kath; Mingxuan Sun; Felix Manuel Zörgiebel; John F Marko
Remote control of DNA-acting enzymes by varying the Brownian dynamics of a distant DNA end.
Hua Bai; Mingxuan Sun; Pallavi Ghosh; Graham F Hatfull; Nigel D F Grindley; John F Marko
Single-molecule analysis reveals the molecular bearing mechanism of DNA strand exchange by a serine recombinase.
Oya Bermek; Nigel D F Grindley; Catherine M Joyce
Distinct roles of the active-site Mg2+ ligands, Asp882 and Asp705, of DNA polymerase I (Klenow fragment) during the prechemistry conformational transitions.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Nigel Grindley (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Hua Bai; Pallavi Ghosh; Nigel D F Grindley; Graham F Hatfull; James E Kath; Mingxuan Sun; Felix Manuel Zörgiebel; John F Marko
Remote control of DNA-acting enzymes by varying the Brownian dynamics of a distant DNA end.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(41):16546-51.
2011: Hua Bai; Mingxuan Sun; Pallavi Ghosh; Graham F Hatfull; Nigel D F Grindley; John F Marko
Single-molecule analysis reveals the molecular bearing mechanism of DNA strand exchange by a serine recombinase.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(18):7419-24.
2011: Oya Bermek; Nigel D F Grindley; Catherine M Joyce
Distinct roles of the active-site Mg2+ ligands, Asp882 and Asp705, of DNA polymerase I (Klenow fragment) during the prechemistry conformational transitions.
The Journal of biological chemistry 2011;286(5):3755-66.
2010: Yusdi Santoso; Catherine M Joyce; Olga Potapova; Ludovic Le Reste; Johannes Hohlbein; Joseph P Torella; Nigel D F Grindley; Achillefs N Kapanidis
Conformational transitions in DNA polymerase I revealed by single-molecule FRET.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(2):715-20.
2008: John D Gehman; Melanie Cocco; Nigel D F Grindley
Chemical shift mapping of gammadelta resolvase dimer and activated tetramer: mechanistic implications for DNA strand exchange.
Biochimica et biophysica acta 2008;1784(12):2086-92.
2008: Catherine M Joyce; Olga Potapova; Angela M DeLucia; Xuanwei Huang; Vandana Purohit Basu; Nigel D F Grindley
Fingers-closing and other rapid conformational changes in DNA polymerase I (Klenow fragment) and their role in nucleotide selectivity.
Biochemistry 2008;47(23):6103-16.
2007: Angela M DeLucia; Nigel D F Grindley; Catherine M Joyce
Conformational changes during normal and error-prone incorporation of nucleotides by a Y-family DNA polymerase detected by 2-aminopurine fluorescence.
Biochemistry 2007;46(38):10790-803.
2006: Angela M DeLucia; Santanov Chaudhuri; Olga Potapova; Nigel D F Grindley; Catherine M Joyce
The properties of steric gate mutants reveal different constraints within the active sites of Y-family and A-family DNA polymerases.
The Journal of biological chemistry 2006;281(37):27286-91.
2006: Satwik Kamtekar; Roger S Ho; Melanie Cocco; Weikai Li; Sandra V C T Wenwieser; Martin R Boocock; Nigel D F Grindley; Thomas A Steitz
Implications of structures of synaptic tetramers of gamma delta resolvase for the mechanism of recombination.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(28):10642-7.
2006: Olga Potapova; Chikio Chan; Angela M DeLucia; Sandra A Helquist; Eric T Kool; Nigel D F Grindley; Catherine M Joyce
DNA polymerase catalysis in the absence of Watson-Crick hydrogen bonds: analysis by single-turnover kinetics.
Biochemistry 2006;45(3):890-8.
2006: Nigel D F Grindley; Katrine L Whiteson; Phoebe A Rice
Mechanisms of site-specific recombination.
Annual review of biochemistry 2006;75():567-605.
2005: Weikai Li; Satwik Kamtekar; Yong Xiong; Gary J Sarkis; Nigel D F Grindley; Thomas A Steitz
Structure of a synaptic gammadelta resolvase tetramer covalently linked to two cleaved DNAs.
Science (New York, N.Y.) 2005;309(5738):1210-5.
2004: Leslie A Lewis; Edruge Cylin; Ho Kyung Lee; Robert Saby; Wilson Wong; Nigel D F Grindley
The left end of IS2: a compromise between transpositional activity and an essential promoter function that regulates the transposition pathway.
Journal of bacteriology 2004;186(3):858-65.
2003: Vandana Purohit; Nigel D F Grindley; Catherine M Joyce
Use of 2-aminopurine fluorescence to examine conformational changes during nucleotide incorporation by DNA polymerase I (Klenow fragment).
Biochemistry 2003;42(34):10200-11.
2003: Andres E Leschziner; Nigel D F Grindley
The architecture of the gammadelta resolvase crossover site synaptic complex revealed by using constrained DNA substrates.
Molecular cell 2003;12(3):775-81.
2003: Angela M DeLucia; Nigel D F Grindley; Catherine M Joyce
An error-prone family Y DNA polymerase (DinB homolog from Sulfolobus solfataricus) uses a 'steric gate' residue for discrimination against ribonucleotides.
Nucleic acids research 2003;31(14):4129-37.
2003: Robert M Turner; Nigel D F Grindley; Catherine M Joyce
Interaction of DNA polymerase I (Klenow fragment) with the single-stranded template beyond the site of synthesis.
Biochemistry 2003;42(8):2373-85.
2002: Olga Potapova; Nigel D F Grindley; Catherine M Joyce
The mutational specificity of the Dbh lesion bypass polymerase and its implications.
The Journal of biological chemistry 2002;277(31):28157-66.
2002: Dana T Minnick; Lixing Liu; Nigel D F Grindley; Thomas A Kunkel; Catherine M Joyce
Discrimination against purine-pyrimidine mispairs in the polymerase active site of DNA polymerase I: a structural explanation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1194-9.
2002: Carolyn Kirby; Al Waring; Thomas J Griffin; Joseph O Falkinham; Nigel D F Grindley; Keith M Derbyshire
Cryptic plasmids of Mycobacterium avium: Tn552 to the rescue.
Molecular microbiology 2002;43(1):173-86.
2001: Leslie A Lewis; Nidhi Gadura; M Greene; R Saby; Nigel D F Grindley
The basis of asymmetry in IS2 transposition.
Molecular microbiology 2001;42(4):887-901.
2001: G J Sarkis; L L Murley; Andres E Leschziner; Martin R Boocock; W Marshall Stark; Nigel D F Grindley
A model for the gamma delta resolvase synaptic complex.
Molecular cell 2001;8(3):623-31.
2001: Yingqian Xu; Olga Potapova; Andres E Leschziner; Nigel D F Grindley; Catherine M Joyce
Contacts between the 5' nuclease of DNA polymerase I and its DNA substrate.
The Journal of biological chemistry 2001;276(32):30167-77.
2001: O R Colegio; Thomas J Griffin; Nigel D F Grindley; Jorge E Galán
In vitro transposition system for efficient generation of random mutants of Campylobacter jejuni.
Journal of bacteriology 2001;183(7):2384-8.
2000: Yingqian Xu; Nigel D F Grindley; Catherine M Joyce
Coordination between the polymerase and 5'-nuclease components of DNA polymerase I of Escherichia coli.
The Journal of biological chemistry 2000;275(27):20949-55.
1999: Thomas J Griffin; L Parsons; Andres E Leschziner; J DeVost; Keith M Derbyshire; Nigel D F Grindley
In vitro transposition of Tn552: a tool for DNA sequencing and mutagenesis.
Nucleic acids research 1999;27(19):3859-65.
1999: P H Arnold; D G Blake; Nigel D F Grindley; Martin R Boocock; W Marshall Stark
Mutants of Tn3 resolvase which do not require accessory binding sites for recombination activity.
The EMBO journal 1999;18(5):1407-14.
1998: L L Murley; Nigel D F Grindley
Architecture of the gamma delta resolvase synaptosome: oriented heterodimers identity interactions essential for synapsis and recombination.
Cell 1998;95(4):553-62.
1998: Andres E Leschziner; Thomas J Griffin; Nigel D F Grindley
Tn552 transposase catalyzes concerted strand transfer in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7345-50.
1998: M Astatke; Nigel D F Grindley; Catherine M Joyce
How E. coli DNA polymerase I (Klenow fragment) distinguishes between deoxy- and dideoxynucleotides.
Journal of molecular biology 1998;278(1):147-65.
1998: M Astatke; K Ng; Nigel D F Grindley; Catherine M Joyce
A single side chain prevents Escherichia coli DNA polymerase I (Klenow fragment) from incorporating ribonucleotides.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3402-7.
1997: Nigel D F Grindley
Site-specific recombination: synapsis and strand exchange revealed.
Current biology : CB 1997;7(10):R608-12.
1997: Leslie A Lewis; Nigel D F Grindley
Two abundant intramolecular transposition products, resulting from reactions initiated at a single end, suggest that IS2 transposes by an unconventional pathway.
Molecular microbiology 1997;25(3):517-29.
1997: Yingqian Xu; V Derbyshire; K Ng; X C Sun; Nigel D F Grindley; Catherine M Joyce
Biochemical and mutational studies of the 5'-3' exonuclease of DNA polymerase I of Escherichia coli.
Journal of molecular biology 1997;268(2):284-302.
1996: Keith M Derbyshire; Nigel D F Grindley
Cis preference of the IS903 transposase is mediated by a combination of transposase instability and inefficient translation.
Molecular microbiology 1996;21(6):1261-72.
1995: Nigel D F Grindley; Andres E Leschziner
DNA transposition: from a black box to a color monitor.
Cell 1995;83(7):1063-6.
1995: Martin R Boocock; X Zhu; Nigel D F Grindley
Catalytic residues of gamma delta resolvase act in cis.
The EMBO journal 1995;14(20):5129-40.
1995: E W May; Nigel D F Grindley
A functional analysis of the inverted repeat of the gamma delta transposable element.
Journal of molecular biology 1995;247(4):578-87.
1995: Andres E Leschziner; Martin R Boocock; Nigel D F Grindley
The tyrosine-6 hydroxyl of gamma delta resolvase is not required for the DNA cleavage and rejoining reactions.
Molecular microbiology 1995;15(5):865-70.
1995: M Astatke; Nigel D F Grindley; Catherine M Joyce
Deoxynucleoside triphosphate and pyrophosphate binding sites in the catalytically competent ternary complex for the polymerase reaction catalyzed by DNA polymerase I (Klenow fragment).
The Journal of biological chemistry 1995;270(4):1945-54.
1993: Nigel D F Grindley
Analysis of a nucleoprotein complex: the synaptosome of gamma delta resolvase.
Science (New York, N.Y.) 1993;262(5134):738-40.
1993: R E Hughes; P A Rice; Thomas A Steitz; Nigel D F Grindley
Protein-protein interactions directing resolvase site-specific recombination: a structure-function analysis.
The EMBO journal 1993;12(4):1447-58.
1993: J M Mazzarelli; M R Ermácora; Robert Fox; Nigel D F Grindley
Mapping interactions between the catalytic domain of resolvase and its DNA substrate using cysteine-coupled EDTA-iron.
Biochemistry 1993;32(12):2979-86.
1992: Catherine M Joyce; X C Sun; Nigel D F Grindley
Reactions at the polymerase active site that contribute to the fidelity of Escherichia coli DNA polymerase I (Klenow fragment).
The Journal of biological chemistry 1992;267(34):24485-500.
1992: Keith M Derbyshire; Nigel D F Grindley
Binding of the IS903 transposase to its inverted repeat in vitro.
The EMBO journal 1992;11(9):3449-55.
1992: A H Polesky; M E Dahlberg; Stephen J Benkovic; Nigel D F Grindley; Catherine M Joyce
Side chains involved in catalysis of the polymerase reaction of DNA polymerase I from Escherichia coli.
The Journal of biological chemistry 1992;267(12):8417-28.
1991: W Marshall Stark; Nigel D F Grindley; G F Hatfull; Martin R Boocock
Resolvase-catalysed reactions between res sites differing in the central dinucleotide of subsite I.
The EMBO journal 1991;10(11):3541-8.
1991: L A Wiater; Nigel D F Grindley
Gamma delta transposase. Purification and analysis of its interaction with a transposon end.
The Journal of biological chemistry 1991;266(3):1841-9.
1991: V Derbyshire; Nigel D F Grindley; Catherine M Joyce
The 3'-5' exonuclease of DNA polymerase I of Escherichia coli: contribution of each amino acid at the active site to the reaction.
The EMBO journal 1991;10(1):17-24.
1990: R E Hughes; G F Hatfull; P Rice; Thomas A Steitz; Nigel D F Grindley
Cooperativity mutants of the gamma delta resolvase identify an essential interdimer interaction.
Cell 1990;63(6):1331-8.
1990: Mark R Sanderson; Paul S Freemont; P A Rice; A Goldman; G F Hatfull; Nigel D F Grindley; Thomas A Steitz
The crystal structure of the catalytic domain of the site-specific recombination enzyme gamma delta resolvase at 2.7 A resolution.
Cell 1990;63(6):1323-9.
1990: L A Wiater; Nigel D F Grindley
Uncoupling of transpositional immunity from gamma delta transposition by a mutation at the end of gamma delta.
Journal of bacteriology 1990;172(9):4959-63.
1990: L A Wiater; Nigel D F Grindley
Integration host factor increases the transpositional immunity conferred by gamma delta ends.
Journal of bacteriology 1990;172(9):4951-8.
1990: A H Polesky; Thomas A Steitz; Nigel D F Grindley; Catherine M Joyce
Identification of residues critical for the polymerase activity of the Klenow fragment of DNA polymerase I from Escherichia coli.
The Journal of biological chemistry 1990;265(24):14579-91.
1990: P Dröge; G F Hatfull; Nigel D F Grindley; Nicholas R Cozzarelli
The two functional domains of gamma delta resolvase act on the same recombination site: implications for the mechanism of strand exchange.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(14):5336-40.
1990: Keith M Derbyshire; M Kramer; Nigel D F Grindley
Role of instability in the cis action of the insertion sequence IS903 transposase.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(11):4048-52.
1990: V Rimphanitchayakit; Nigel D F Grindley
Saturation mutagenesis of the DNA site bound by the small carboxy-terminal domain of gamma delta resolvase.
The EMBO journal 1990;9(3):719-25.
1989: G F Hatfull; Mark R Sanderson; Paul S Freemont; P R Raccuia; Nigel D F Grindley; Thomas A Steitz
Preparation of heavy-atom derivatives using site-directed mutagenesis. Introduction of cysteine residues into gamma delta resolvase.
Journal of molecular biology 1989;208(4):661-7.
1989: V Rimphanitchayakit; G F Hatfull; Nigel D F Grindley
The 43 residue DNA binding domain of gamma delta resolvase binds adjacent major and minor grooves of DNA.
Nucleic acids research 1989;17(3):1035-50.
1988: J J Salvo; Nigel D F Grindley
The gamma delta resolvase bends the res site into a recombinogenic complex.
The EMBO journal 1988;7(11):3609-16.
1988: L A Wiater; Nigel D F Grindley
Gamma delta transposase and integration host factor bind cooperatively at both ends of gamma delta.
The EMBO journal 1988;7(6):1907-11.
1988: E Falvey; G F Hatfull; Nigel D F Grindley
Uncoupling of the recombination and topoisomerase activities of the gamma delta resolvase by a mutation at the crossover point.
Nature 1988;332(6167):861-3.
1987: J J Salvo; Nigel D F Grindley
Helical phasing between DNA bends and the determination of bend direction.
Nucleic acids research 1987;15(23):9771-9.
1987: Keith M Derbyshire; L Hwang; Nigel D F Grindley
Genetic analysis of the interaction of the insertion sequence IS903 transposase with its terminal inverted repeats.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(22):8049-53.
1987: G F Hatfull; S M Noble; Nigel D F Grindley
The gamma delta resolvase induces an unusual DNA structure at the recombinational crossover point.
Cell 1987;49(1):103-10.
1987: E Falvey; Nigel D F Grindley
Contacts between gamma delta resolvase and the gamma delta res site.
The EMBO journal 1987;6(3):815-21.
1986: Keith M Derbyshire; Nigel D F Grindley
Replicative and conservative transposition in bacteria.
Cell 1986;47(3):325-7.
1986: G F Hatfull; Nigel D F Grindley
Analysis of gamma delta resolvase mutants in vitro: evidence for an interaction between serine-10 of resolvase and site I of res.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(15):5429-33.
1986: Keith M Derbyshire; J J Salvo; Nigel D F Grindley
A simple and efficient procedure for saturation mutagenesis using mixed oligodeoxynucleotides.
Gene 1986;46(2-3):145-52.
1985: Catherine M Joyce; D M Fujii; H S Laks; C M Hughes; Nigel D F Grindley
Genetic mapping and DNA sequence analysis of mutations in the polA gene of Escherichia coli.
Journal of molecular biology 1985;186(2):283-93.
1984: Catherine M Joyce; Nigel D F Grindley
Method for determining whether a gene of Escherichia coli is essential: application to the polA gene.
Journal of bacteriology 1984;158(2):636-43.
1984: T A Weinert; Keith M Derbyshire; F M Hughson; Nigel D F Grindley
Replicative and conservative transpositional recombination of insertion sequences.
Cold Spring Harbor symposia on quantitative biology 1984;49():251-60.
1983: T A Weinert; N A Schaus; Nigel D F Grindley
Insertion sequence duplication in transpositional recombination.
Science (New York, N.Y.) 1983;222(4625):755-65.
1983: Catherine M Joyce; Nigel D F Grindley
Construction of a plasmid that overproduces the large proteolytic fragment (Klenow fragment) of DNA polymerase I of Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(7):1830-4.
1982: Catherine M Joyce; Nigel D F Grindley
Identification of two genes immediately downstream from the polA gene of Escherichia coli.
Journal of bacteriology 1982;152(3):1211-9.
1982: Nigel D F Grindley; M R Lauth; R G Wells; Robert J Wityk; J J Salvo; R R Reed
Transposon-mediated site-specific recombination: identification of three binding sites for resolvase at the res sites of gamma delta and Tn3.
Cell 1982;30(1):19-27.
1982: Catherine M Joyce; W S Kelley; Nigel D F Grindley
Nucleotide sequence of the Escherichia coli polA gene and primary structure of DNA polymerase I.
The Journal of biological chemistry 1982;257(4):1958-64.
1981: Nigel D F Grindley; Catherine M Joyce
Analysis of the structure and function of the kanamycin-resistance transposon Tn903.
Cold Spring Harbor symposia on quantitative biology 1981;45 Pt 1():125-33.
1980: Nigel D F Grindley; Catherine M Joyce
Genetic and DNA sequence analysis of the kanamycin resistance transposon Tn903.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(12):7176-80.