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Sergio Grinstein

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Bryan Heit; Kevin C Kain; Hani Kim; Clifford A Lowell; William S Trimble; Diana Castaño; Richard Collins; Gabriela Cosío; Sergio Grinstein
Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization.
Hisayoshi Hayashi; Hetal S Kocinsky; Devishree Krishnan; John Orlowski; Yuichi Suzuki; Atsushi Tamura; Sachiko Tsukita; Peter S Aronson; Sergio Grinstein; R Todd Alexander
Ezrin is required for the functional regulation of the epithelial sodium proton exchanger, NHE3.
Pontus Nordenfelt; Lars Björck; Sergio Grinstein; Hans Tapper
V-ATPase-mediated phagosomal acidification is impaired by Streptococcus pyogenes through Mga-regulated surface proteins.

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2013: Bryan Heit; Kevin C Kain; Hani Kim; Clifford A Lowell; William S Trimble; Diana Castaño; Richard Collins; Gabriela Cosío; Sergio Grinstein
Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization.
Developmental cell 2013;24(4):372-83.
2013: Hisayoshi Hayashi; Hetal S Kocinsky; Devishree Krishnan; John Orlowski; Yuichi Suzuki; Atsushi Tamura; Sachiko Tsukita; Peter S Aronson; Sergio Grinstein; R Todd Alexander
Ezrin is required for the functional regulation of the epithelial sodium proton exchanger, NHE3.
PloS one 2013;8(2):e55623.
2012: Pontus Nordenfelt; Lars Björck; Sergio Grinstein; Hans Tapper
V-ATPase-mediated phagosomal acidification is impaired by Streptococcus pyogenes through Mga-regulated surface proteins.
Microbes and infection / Institut Pasteur 2012;14(14):1319-29.
2012: Helen Sarantis; Sergio Grinstein
Subversion of phagocytosis for pathogen survival.
Cell host & microbe 2012;12(4):419-31.
2012: Khuloud Jaqaman; Sergio Grinstein
Regulation from within: the cytoskeleton in transmembrane signaling.
Trends in cell biology 2012;22(10):515-26.
2012: Sergio Grinstein
Phagocytosis here and now.
Traffic (Copenhagen, Denmark) 2012;13(8):1041.
2012: Gregory D Fairn; Sergio Grinstein
How nascent phagosomes mature to become phagolysosomes.
Trends in immunology 2012;33(8):397-405.
2012: Helen Sarantis; Ralph R Isberg; Daniel M Balkin; John H Brumell; Pietro De Camilli; Sergio Grinstein
Yersinia entry into host cells requires Rab5-dependent dephosphorylation of PI(4,5)P₂ and membrane scission.
Cell host & microbe 2012;11(2):117-28.
2012: Ronald S Flannagan; Gregory P Downey; Kassidy K Huynh; Valentin Jaumouillé; Jonathan D Plumb; Miguel A Valvano; Sergio Grinstein
Burkholderia cenocepacia disrupts host cell actin cytoskeleton by inactivating Rac and Cdc42.
Cellular microbiology 2012;14(2):239-54.
2012: Benjamin H Lee; Nades Palaniyar; Dana J Philpott; Sergio Grinstein; David M Hwang; Jim Hu
Activation of P2X(7) receptor by ATP plays an important role in regulating inflammatory responses during acute viral infection.
PloS one 2012;7(4):e35812.
2012: Helen Sarantis; Sergio Grinstein
Monitoring phospholipid dynamics during phagocytosis: application of genetically-encoded fluorescent probes.
Methods in cell biology 2012;108():429-44.
2012: Bernhard Roppenser; Sergio Grinstein; John H Brumell
Modulation of host phosphoinositide metabolism during Salmonella invasion by the type III secreted effector SopB.
Methods in cell biology 2012;108():173-86.
2012: Ronald S Flannagan; Valentin Jaumouillé; Sergio Grinstein
The cell biology of phagocytosis.
Annual review of pathology 2012;7():61-98.
2011: Gregory D Fairn; Martin Hermansson; Pentti Somerharju; Sergio Grinstein
Phosphatidylserine is polarized and required for proper Cdc42 localization and for development of cell polarity.
Nature cell biology 2011;13(12):1424-30.
2011: Natalia A Kaniuk; Marija Landekic; Michael McClelland; Tobias Meyer; Shuvadeep Mitra; Tony Pawson; Laurence Pelletier; Helene Andrews-Polymenis; Richard D Bagshaw; Malina A Bakowski; Virginie Braun; Veronica Canadien; Sergio Grinstein; Won Do Heo; Ju Huang; John H Brumell
Salmonella exploits Arl8B-directed kinesin activity to promote endosome tubulation and cell-to-cell transfer.
Cellular microbiology 2011;13(11):1812-23.
2011: Luciene R Carraro-Lacroix; Gregory D Fairn; Valentin Jaumouillé; Sergio Grinstein
A weak base-generating system suitable for selective manipulation of lysosomal pH.
Traffic (Copenhagen, Denmark) 2011;12(11):1490-500.
2011: Khuloud Jaqaman; Hirotaka Kuwata; Nicolas Touret; William S Trimble; Richard Collins; Gaudenz Danuser; Sergio Grinstein
Cytoskeletal control of CD36 diffusion promotes its receptor and signaling function.
Cell 2011;146(4):593-606.
2011: Mirkka Koivusalo; David Mason; Benjamin E Steinberg; Sergio Grinstein
In situ measurement of the electrical potential across the lysosomal membrane using FRET.
Traffic (Copenhagen, Denmark) 2011;12(8):972-82.
2011: Gregory D Fairn; Sergio Grinstein; Lars Kuerschner; Samantha Murphy; Nicole L Schieber; Richard I Webb; Nicholas Ariotti; Robert G Parton
High-resolution mapping reveals topologically distinct cellular pools of phosphatidylserine.
The Journal of cell biology 2011;194(2):257-75.
2011: Ronald S Flannagan; Sergio Grinstein
Editorial: Fly fishing with RNAi catches novel effectors of phagocytosis.
Journal of leukocyte biology 2011;89(5):643-5.
2011: Valentin Jaumouillé; Sergio Grinstein
Receptor mobility, the cytoskeleton, and particle binding during phagocytosis.
Current opinion in cell biology 2011;23(1):22-9.
2011: Jason G Kay; Sergio Grinstein
Sensing phosphatidylserine in cellular membranes.
Sensors (Basel, Switzerland) 2011;11(2):1744-55.
2011: bryan heit; Tony Yeung; Sergio Grinstein
Changes in mitochondrial surface charge mediate recruitment of signaling molecules during apoptosis.
American journal of physiology. Cell physiology 2011;300(1):C33-41.
2010: Ronald S Flannagan; Rene E Harrison; Christopher M Yip; Khuloud Jaqaman; Sergio Grinstein
Dynamic macrophage "probing" is required for the efficient capture of phagocytic targets.
The Journal of cell biology 2010;191(6):1205-18.
2010: Benjamin H Lee; rahul kushwah; Jing Wu; Philip Ng; Nades Palaniyar; Sergio Grinstein; Dana J Philpott; Jim Hu
Adenoviral vectors stimulate innate immune responses in macrophages through cross-talk with epithelial cells.
Immunology letters 2010;134(1):93-102.
2010: Michal Bohdanowicz; Gabriela Cosío; Jonathan M Backer; Sergio Grinstein
Class I and class III phosphoinositide 3-kinases are required for actin polymerization that propels phagosomes.
The Journal of cell biology 2010;191(5):999-1012.
2010: Sergio Grinstein
Imaging signal transduction during phagocytosis: phospholipids, surface charge, and electrostatic interactions.
American journal of physiology. Cell physiology 2010;299(5):C876-81.
2010: Azza Gramoun; Tetsuya Goto; Tommy Nordström; Ori D Rotstein; Sergio Grinstein; Johan N M Heersche; Morris F Manolson
Bone matrix proteins and extracellular acidification: potential co-regulators of osteoclast morphology.
Journal of cellular biochemistry 2010;111(2):350-61.
2010: Virginie Braun; Anthony Wong; Marija Landekic; Wan Jin Hong; Sergio Grinstein; John H Brumell
Sorting nexin 3 (SNX3) is a component of a tubular endosomal network induced by Salmonella and involved in maturation of the Salmonella-containing vacuole.
Cellular microbiology 2010;12(9):1352-67.
2010: Benjamin E Steinberg; Kassidy K Huynh; Alexandre Brodovitch; Sabrina Jabs; Tobias Stauber; Thomas J Jentsch; Sergio Grinstein
A cation counterflux supports lysosomal acidification.
The Journal of cell biology 2010;189(7):1171-86.
2010: Malina A Bakowski; Virginie Braun; Grace Y Lam; Tony Yeung; Won Do Heo; Tobias Meyer; B Brett Finlay; Sergio Grinstein; John H Brumell
The phosphoinositide phosphatase SopB manipulates membrane surface charge and trafficking of the Salmonella-containing vacuole.
Cell host & microbe 2010;7(6):453-62.
2010: Michal Bohdanowicz; Sergio Grinstein
Vesicular traffic: a Rab SANDwich.
Current biology : CB 2010;20(7):R311-4.
2010: Mirkka Koivusalo; Christopher Welch; Hisayoshi Hayashi; Cameron C Scott; Moshe Kim; Todd Alexander; Nicolas Touret; Klaus M Hahn; Sergio Grinstein
Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling.
The Journal of cell biology 2010;188(4):547-63.
2010: Kassidy K Huynh; Jonathan D Plumb; Gregory P Downey; Miguel A Valvano; Sergio Grinstein
Inactivation of macrophage Rab7 by Burkholderia cenocepacia.
Journal of innate immunity 2010;2(6):522-33.
2010: Peter A Leventis; Sergio Grinstein
The distribution and function of phosphatidylserine in cellular membranes.
Annual review of biophysics 2010;39():407-27.
2010: Ronald S Flannagan; Sergio Grinstein
The application of fluorescent probes for the analysis of lipid dynamics during phagocytosis.
Methods in molecular biology (Clifton, N.J.) 2010;591():121-34.
2009: Gregory D Fairn; Koji Ogata; Roberto J Botelho; Philip D Stahl; Richard A Anderson; Pietro De Camilli; Tobias Meyer; Shoshana Wodak; Sergio Grinstein
An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis.
The Journal of cell biology 2009;187(5):701-14.
2009: Anne Fortier; Karine Doiron; Maya Saleh; Sergio Grinstein; Philippe Gros
Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4.
Infection and immunity 2009;77(11):4794-805.
2009: Richard F Collins; Nicolas Touret; Hirotaka Kuwata; Narendra Tandon; Sergio Grinstein; William S Trimble
Uptake of oxidized low density lipoprotein by CD36 occurs by an actin-dependent pathway distinct from macropinocytosis.
The Journal of biological chemistry 2009;284(44):30288-97.
2009: Tony Yeung; bryan heit; Jean-Francois Dubuisson; Gregory D Fairn; Basil Chiu; Robert Inman; Andras Kapus; Michele S Swanson; Sergio Grinstein
Contribution of phosphatidylserine to membrane surface charge and protein targeting during phagosome maturation.
The Journal of cell biology 2009;185(5):917-28.
2009: Ronald S Flannagan; Gabriela Cosío; Sergio Grinstein
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
Nature reviews. Microbiology 2009;7(5):355-66.
2009: Ju Huang; Veronica Canadien; Grace Y Lam; Benjamin E Steinberg; Mary C Dinauer; Marco Magalhaes; Glogauer Michael; Sergio Grinstein; John H Brumell
Activation of antibacterial autophagy by NADPH oxidases.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(15):6226-31.
2009: Mirkka Koivusalo; Andras Kapus; Sergio Grinstein
Sensors, transducers, and effectors that regulate cell size and shape.
The Journal of biological chemistry 2009;284(11):6595-9.
2009: Xing Jun Li; Wei Tian; Natalie Stull; Sergio Grinstein; Simon Atkinson; Mary C Dinauer
A fluorescently tagged C-terminal fragment of p47phox detects NADPH oxidase dynamics during phagocytosis.
Molecular biology of the cell 2009;20(5):1520-32.
2009: Benjamin E Steinberg; Sergio Grinstein
Analysis of macrophage phagocytosis: quantitative assays of phagosome formation and maturation using high-throughput fluorescence microscopy.
Methods in molecular biology (Clifton, N.J.) 2009;531():45-56.
2008: Wei Tian; Xing Jun Li; Natalie Stull; Wenyu Ming; Chang-Il Suh; Sarah A Bissonnette; Michael B Yaffe; Sergio Grinstein; Simon J Atkinson; Mary C Dinauer
Fc gamma R-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome.
Blood 2008;112(9):3867-77.
2008: Gustavo V Mallo; Marianela Espina; Adam C Smith; Mauricio R Terebiznik; Ainel Alemán; B Brett Finlay; Lucia E Rameh; Sergio Grinstein; John H Brumell
SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34.
The Journal of cell biology 2008;182(4):741-52.
2008: Khuloud Jaqaman; Dinah Loerke; Marcel Mettlen; Hirotaka Kuwata; Sergio Grinstein; Sandra L Schmid; Gaudenz Danuser
Robust single-particle tracking in live-cell time-lapse sequences.
Nature methods 2008;5(8):695-702.
2008: Kassidy K Huynh; Sergio Grinstein
Phagocytosis: dynamin's dual role in phagosome biogenesis.
Current biology : CB 2008;18(13):R563-5.
2008: Benjamin E Steinberg; Sergio Grinstein
Pathogen destruction versus intracellular survival: the role of lipids as phagosomal fate determinants.
The Journal of clinical investigation 2008;118(6):2002-11.
2008: Gregory D Fairn; Sergio Grinstein
Cell biology. A one-sided signal.
Science (New York, N.Y.) 2008;320(5875):458-60.
2008: Yi-Wei Huang; Ming Yan; Richard F Collins; Jessica E Diciccio; Sergio Grinstein; William S Trimble
Mammalian septins are required for phagosome formation.
Molecular biology of the cell 2008;19(4):1717-26.
2008: Hisayoshi Hayashi; O Aharonovitz; R Todd Alexander; Nicolas Touret; Wendy Furuya; John Orlowski; Sergio Grinstein
Na+/H+ exchange and pH regulation in the control of neutrophil chemokinesis and chemotaxis.
American journal of physiology. Cell physiology 2008;294(2):C526-34.
2008: Tony Yeung; Gary E Gilbert; Jialan Shi; John R Silvius; Andras Kapus; Sergio Grinstein
Membrane phosphatidylserine regulates surface charge and protein localization.
Science (New York, N.Y.) 2008;319(5860):210-3.
2008: Gabriela Cosío; Sergio Grinstein
Analysis of phosphoinositide dynamics during phagocytosis using genetically encoded fluorescent biosensors.
Methods in molecular biology (Clifton, N.J.) 2008;445():287-300.
2007: Eric Vachon; Raiza Martin; Vivian Kwok; Vera Cherepanov; Chung-Wai Chow; Claire Doerschuk; Jonathan Plumb; Sergio Grinstein; Gregory P Downey
CD44-mediated phagocytosis induces inside-out activation of complement receptor-3 in murine macrophages.
Blood 2007;110(13):4492-502.
2007: Kassidy K Huynh; Jason G Kay; Jennifer L Stow; Sergio Grinstein
Fusion, fission, and secretion during phagocytosis.
Physiology (Bethesda, Md.) 2007;22():366-72.
2007: Neil M Goldenberg; Sergio Grinstein; Mel Silverman
Golgi-bound Rab34 is a novel member of the secretory pathway.
Molecular biology of the cell 2007;18(12):4762-71.
2007: Tony Yeung; Sergio Grinstein
Lipid signaling and the modulation of surface charge during phagocytosis.
Immunological reviews 2007;219():17-36.
2007: Kassidy K Huynh; Sergio Grinstein
Regulation of vacuolar pH and its modulation by some microbial species.
Microbiology and molecular biology reviews : MMBR 2007;71(3):452-62.
2007: Marcelo G Binker; Laura I Cosen-Binker; Mauricio R Terebiznik; Gustavo V Mallo; Shannon E McCaw; Eeva-Liisa Eskelinen; Marion Willenborg; John H Brumell; Paul Saftig; Sergio Grinstein; Scott D Gray-Owen
Arrested maturation of Neisseria-containing phagosomes in the absence of the lysosome-associated membrane proteins, LAMP-1 and LAMP-2.
Cellular microbiology 2007;9(9):2153-66.
2007: John Orlowski; Sergio Grinstein
Emerging roles of alkali cation/proton exchangers in organellar homeostasis.
Current opinion in cell biology 2007;19(4):483-92.
2007: Warren L Lee; David Mason; Alan D Schreiber; Sergio Grinstein
Quantitative analysis of membrane remodeling at the phagocytic cup.
Molecular biology of the cell 2007;18(8):2883-92.
2007: William S Trimble; Sergio Grinstein
TB or not TB: calcium regulation in mycobacterial survival.
Cell 2007;130(1):12-4.
2007: Benjamin E Steinberg; Nicolas Touret; Mariana Vargas-Caballero; Sergio Grinstein
In situ measurement of the electrical potential across the phagosomal membrane using FRET and its contribution to the proton-motive force.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(22):9523-8.
2007: Ming Yan; Caterina Di Ciano-Oliveira; Sergio Grinstein; William S Trimble
Coronin function is required for chemotaxis and phagocytosis in human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5769-78.
2007: Warren L Lee; Gabriela Cosio; Keith Ireton; Sergio Grinstein
Role of CrkII in Fcgamma receptor-mediated phagocytosis.
The Journal of biological chemistry 2007;282(15):11135-43.
2007: David Mason; Gustavo V Mallo; Mauricio R Terebiznik; Bernard Payrastre; B Brett Finlay; John H Brumell; Lucia E Rameh; Sergio Grinstein
Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase.
The Journal of general physiology 2007;129(4):267-83.
2007: Benjamin E Steinberg; Sergio Grinstein
Unconventional roles of the NADPH oxidase: signaling, ion homeostasis, and cell death.
Science's STKE : signal transduction knowledge environment 2007;2007(379):pe11.
2007: R Todd Alexander; Anatoly Malevanets; Anne M Durkan; Hetal S Kocinsky; Peter S Aronson; John Orlowski; Sergio Grinstein
Membrane curvature alters the activation kinetics of the epithelial Na+/H+ exchanger, NHE3.
The Journal of biological chemistry 2007;282(10):7376-84.
2007: Benjamin E Steinberg; Cameron C Scott; Sergio Grinstein
High-throughput assays of phagocytosis, phagosome maturation, and bacterial invasion.
American journal of physiology. Cell physiology 2007;292(2):C945-52.
2007: Adam C Smith; Won Do Heo; Virginie Braun; Xiuju Jiang; Chloe Macrae; James E Casanova; Marci A Scidmore; Sergio Grinstein; Tobias Meyer; John H Brumell
A network of Rab GTPases controls phagosome maturation and is modulated by Salmonella enterica serovar Typhimurium.
The Journal of cell biology 2007;176(3):263-8.
2007: Kassidy K Huynh; Eeva-Liisa Eskelinen; Cameron C Scott; Anatoly Malevanets; Paul Saftig; Sergio Grinstein
LAMP proteins are required for fusion of lysosomes with phagosomes.
The EMBO journal 2007;26(2):313-24.
2007: Benjamin E Steinberg; Sergio Grinstein
Assessment of phagosome formation and maturation by fluorescence microscopy.
Methods in molecular biology (Clifton, N.J.) 2007;412():289-300.
2007: Julie Lamothe; Kassidy K Huynh; Sergio Grinstein; Miguel A Valvano
Intracellular survival of Burkholderia cenocepacia in macrophages is associated with a delay in the maturation of bacteria-containing vacuoles.
Cellular microbiology 2007;9(1):40-53.
2006: Patricia Mero; Christine Y Zhang; Zhen-Yu Huang; Moo-Kyung Kim; Alan D Schreiber; Sergio Grinstein; James W Booth
Phosphorylation-independent ubiquitylation and endocytosis of Fc gammaRIIA.
The Journal of biological chemistry 2006;281(44):33242-9.
2006: Tracy Tan; Warren L Lee; David C Alexander; Sergio Grinstein; Jun Liu
The ESAT-6/CFP-10 secretion system of Mycobacterium marinum modulates phagosome maturation.
Cellular microbiology 2006;8(9):1417-29.
2006: Chang-Il Suh; Natalie Stull; Xing Jun Li; Wei Tian; Marianne O Price; Sergio Grinstein; Michael B Yaffe; Simon Atkinson; Mary C Dinauer
The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis.
The Journal of experimental medicine 2006;203(8):1915-25.
2006: Tony Yeung; Barish Ozdamar; Paul Paroutis; Sergio Grinstein
Lipid metabolism and dynamics during phagocytosis.
Current opinion in cell biology 2006;18(4):429-37.
2006: Tony Yeung; Mauricio Terebiznik; Liming Yu; John R Silvius; Wasif M Abidi; Mark Philips; Tim Levine; Andras Kapus; Sergio Grinstein
Receptor activation alters inner surface potential during phagocytosis.
Science (New York, N.Y.) 2006;313(5785):347-51.
2006: Elaine F Corbett-Nelson; David Mason; John G Marshall; Yves Collette; Sergio Grinstein
Signaling-dependent immobilization of acylated proteins in the inner monolayer of the plasma membrane.
The Journal of cell biology 2006;174(2):255-65.
2006: Eric Vachon; Raiza Martin; Jonathan Plumb; Vivian Kwok; R William Vandivier; Glogauer Michael; Andras Kapus; Xiaomin Wang; Chung-Wai Chow; Sergio Grinstein; Gregory P Downey
CD44 is a phagocytic receptor.
Blood 2006;107(10):4149-58.
2006: R Todd Alexander; Sergio Grinstein
Na+/H+ exchangers and the regulation of volume.
Acta physiologica (Oxford, England) 2006;187(1-2):159-67.
2006: Nicolas Touret; Sergio Grinstein
[Dynamic and functional characteristics of the phagosomal membrane].
Médecine sciences : M/S 2006;22(5):457-8.
2006: Theo J Moraes; Jonathan Plumb; Raiza Martin; Eric Vachon; Vera Cherepanov; Adeline Koh; Carola Loeve; Jenny Jongstra-Bilen; Joanna H Zurawska; Julianne Kus; Lori L Burrows; Sergio Grinstein; Gregory P Downey
Abnormalities in the pulmonary innate immune system in cystic fibrosis.
American journal of respiratory cell and molecular biology 2006;34(3):364-74.
2006: Koichi Tabeta; Kasper Hoebe; edith janssen; Xin Du; Philippe Georgel; Karine Crozat; Suzanne Mudd; Navjiwan Mann; Sosathya Sovath; Jason Goode; Louis Shamel; Anat Herskovits; Daniel A Portnoy; Michael Cooke; Lisa Tarantino; Timothy Wiltshire; Benjamin E Steinberg; Sergio Grinstein; Bruce Beutler
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9.
Nature immunology 2006;7(2):156-64.
2006: R Todd Alexander; Sergio Grinstein
Activation of kinases upon volume changes: role in cellular homeostasis.
Contributions to nephrology 2006;152():105-24.
2006: Natalia Martin-Orozco; Nicolas Touret; Michael L Zaharik; Edwin Park; raoul kopelman; Samuel Miller; B Brett Finlay; Philippe Gros; Sergio Grinstein
Visualization of vacuolar acidification-induced transcription of genes of pathogens inside macrophages.
Molecular biology of the cell 2006;17(1):498-510.
2005: Nicolas Touret; Paul Paroutis; Mauricio Terebiznik; Rene E Harrison; Sergio Trombetta; Marc Pypaert; Amy Chow; Aimin Jiang; James Shaw; Christopher Yip; Hsiao-Ping Moore; Nicole N Van Der Wel; Diane Houben; Peter J Peters; Chantal de Chastellier; Ira Mellman; Sergio Grinstein
Quantitative and dynamic assessment of the contribution of the ER to phagosome formation.
Cell 2005;123(1):157-70.
2005: Steven Lam-Yuk-Tseung; Nicolas Touret; Sergio Grinstein; Philippe Gros
Carboxyl-terminus determinants of the iron transporter DMT1/SLC11A2 isoform II (-IRE/1B) mediate internalization from the plasma membrane into recycling endosomes.
Biochemistry 2005;44(36):12149-59.
2005: R Todd Alexander; Wendy Furuya; Katalin Szászi; John Orlowski; Sergio Grinstein
Rho GTPases dictate the mobility of the Na/H exchanger NHE3 in epithelia: role in apical retention and targeting.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(34):12253-8.
2005: Shirley M L Tse; David Mason; Roberto J Botelho; Basil Chiu; Mary Reyland; Kentaro Hanada; Robert D Inman; Sergio Grinstein
Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis.
The Journal of biological chemistry 2005;280(26):25210-5.
2005: Ming Yan; Richard F Collins; Sergio Grinstein; William S Trimble
Coronin-1 function is required for phagosome formation.
Molecular biology of the cell 2005;16(7):3077-87.
2005: Tony Yeung; Nicolas Touret; Sergio Grinstein
Quantitative fluorescence microscopy to probe intracellular microenvironments.
Current opinion in microbiology 2005;8(3):350-8.
2005: Nicolas Touret; Paul Paroutis; Sergio Grinstein
The nature of the phagosomal membrane: endoplasmic reticulum versus plasmalemma.
Journal of leukocyte biology 2005;77(6):878-85.
2005: Cameron C Scott; Wendy Dobson; Roberto J Botelho; Natasha Coady-Osberg; Philippe Chavrier; David A Knecht; Colin Heath; Philip Stahl; Sergio Grinstein
Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis.
The Journal of cell biology 2005;169(1):139-49.
2005: Warren L Lee; Moo-Kyung Kim; Alan D Schreiber; Sergio Grinstein
Role of ubiquitin and proteasomes in phagosome maturation.
Molecular biology of the cell 2005;16(4):2077-90.
2005: Barry B Rubin; Gregory P Downey; Adeline Koh; Norbert Degousee; Farideh Ghomashchi; Laxman Nallan; Eva Stefanski; Denis W Harkin; Chunxiang Sun; Brian P Smart; Thomas F Lindsay; Vera Cherepanov; Eric Vachon; David Kelvin; Martin Sadilek; Glenn E Brown; Michael B Yaffe; Jonathan Plumb; Sergio Grinstein; Glogauer Michael; Michael H Gelb
Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity.
The Journal of biological chemistry 2005;280(9):7519-29.
2004: Nicolas Touret; Natalia Martin-Orozco; Paul Paroutis; Wendy Furuya; Steven Lam-Yuk-Tseung; John Forbes; Philippe Gros; Sergio Grinstein
Molecular and cellular mechanisms underlying iron transport deficiency in microcytic anemia.
Blood 2004;104(5):1526-33.
2004: Paul Paroutis; Nicolas Touret; Sergio Grinstein
The pH of the secretory pathway: measurement, determinants, and regulation.
Physiology (Bethesda, Md.) 2004;19():207-15.
2004: Rene E Harrison; John H Brumell; Arian Khandani; Cecilia Bucci; Cameron C Scott; Xiuju Jiang; B Brett Finlay; Sergio Grinstein
Salmonella impairs RILP recruitment to Rab7 during maturation of invasion vacuoles.
Molecular biology of the cell 2004;15(7):3146-54.
2004: Chung-Wai Chow; Gregory P Downey; Sergio Grinstein
Measurements of phagocytosis and phagosomal maturation.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2004;Chapter 15():Unit 15.7.
2004: Otilia V Vieira; Rene E Harrison; Cameron C Scott; Harald Stenmark; David Alexander; Jun Liu; Jean Gruenberg; Alan D Schreiber; Sergio Grinstein
Acquisition of Hrs, an essential component of phagosomal maturation, is impaired by mycobacteria.
Molecular and cellular biology 2004;24(10):4593-604.
2004: Hisayoshi Hayashi; Katalin Szászi; Natasha Coady-Osberg; Wendy Furuya; Anthony P Bretscher; John Orlowski; Sergio Grinstein
Inhibition and redistribution of NHE3, the apical Na+/H+ exchanger, by Clostridium difficile toxin B.
The Journal of general physiology 2004;123(5):491-504.
2004: Warren L Lee; Sergio Grinstein
Immunology. The tangled webs that neutrophils weave.
Science (New York, N.Y.) 2004;303(5663):1477-8.
2004: John H Brumell; Sergio Grinstein
Salmonella redirects phagosomal maturation.
Current opinion in microbiology 2004;7(1):78-84.
2004: John Orlowski; Sergio Grinstein
Diversity of the mammalian sodium/proton exchanger SLC9 gene family.
Pflügers Archiv : European journal of physiology 2004;447(5):549-65.
2004: Roberto J Botelho; Cameron C Scott; Sergio Grinstein
Phosphoinositide involvement in phagocytosis and phagosome maturation.
Current topics in microbiology and immunology 2004;282():1-30.
2003: Jenny Jongstra-Bilen; Rene Harrison; Sergio Grinstein
Fcgamma-receptors induce Mac-1 (CD11b/CD18) mobilization and accumulation in the phagocytic cup for optimal phagocytosis.
The Journal of biological chemistry 2003;278(46):45720-9.
2003: Warren L Lee; Rene E Harrison; Sergio Grinstein
Phagocytosis by neutrophils.
Microbes and infection / Institut Pasteur 2003;5(14):1299-306.
2003: Rene E Harrison; Cecilia Bucci; Otilia V Vieira; Trina A Schroer; Sergio Grinstein
Phagosomes fuse with late endosomes and/or lysosomes by extension of membrane protrusions along microtubules: role of Rab7 and RILP.
Molecular and cellular biology 2003;23(18):6494-506.
2003: Cameron C Scott; Wendy Furuya; William S Trimble; Sergio Grinstein
Activation of store-operated calcium channels: assessment of the role of snare-mediated vesicular transport.
The Journal of biological chemistry 2003;278(33):30534-9.
2003: Nicolas Touret; Wendy Furuya; John Forbes; Philippe Gros; Sergio Grinstein
Dynamic traffic through the recycling compartment couples the metal transporter Nramp2 (DMT1) with the transferrin receptor.
The Journal of biological chemistry 2003;278(28):25548-57.
2003: Haihua Gu; Roberto J Botelho; Min Yu; Sergio Grinstein; Benjamin G Neel
Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis.
The Journal of cell biology 2003;161(6):1151-61.
2003: Mohamed Benharouga; Manu Sharma; Jeffry So; Martin Haardt; Luke Drzymala; Milka Popov; Blanche Schwapach; Sergio Grinstein; Kai Du; Gergely L Lukacs
The role of the C terminus and Na+/H+ exchanger regulatory factor in the functional expression of cystic fibrosis transmembrane conductance regulator in nonpolarized cells and epithelia.
The Journal of biological chemistry 2003;278(24):22079-89.
2003: Cameron C Scott; Roberto J Botelho; Sergio Grinstein
Phagosome maturation: a few bugs in the system.
The Journal of membrane biology 2003;193(3):137-52.
2003: Nada Jabado; Patricia Cuellar-Mata; Sergio Grinstein; Philippe Gros
Iron chelators modulate the fusogenic properties of Salmonella-containing phagosomes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):6127-32.
2003: John H Brumell; Sergio Grinstein
Role of lipid-mediated signal transduction in bacterial internalization.
Cellular microbiology 2003;5(5):287-97.
2003: James W Booth; David Telio; Edward H Liao; Shannon E McCaw; Tsuyoshi Matsuo; Sergio Grinstein; Scott D Gray-Owen
Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae.
The Journal of biological chemistry 2003;278(16):14037-45.
2003: Otilia V Vieira; Cecilia Bucci; Rene E Harrison; William S Trimble; Letizia Lanzetti; Jean Gruenberg; Alan D Schreiber; Philip D Stahl; Sergio Grinstein
Modulation of Rab5 and Rab7 recruitment to phagosomes by phosphatidylinositol 3-kinase.
Molecular and cellular biology 2003;23(7):2501-14.
2003: Patrice Dombrosky-Ferlan; Anatoly Grishin; Roberto J Botelho; Matthew Sampson; Lin Wang; William A Rudert; Sergio Grinstein; Seth J Corey
Felic (CIP4b), a novel binding partner with the Src kinase Lyn and Cdc42, localizes to the phagocytic cup.
Blood 2003;101(7):2804-9.
2003: Shirley M L Tse; Wendy Furuya; Elizabeth Gold; Alan D Schreiber; Kirsten Sandvig; Robert D Inman; Sergio Grinstein
Differential role of actin, clathrin, and dynamin in Fc gamma receptor-mediated endocytosis and phagocytosis.
The Journal of biological chemistry 2003;278(5):3331-8.
2002: Nicolas Touret; Sergio Grinstein
Voltage-gated proton "channels": a spectator's viewpoint.
The Journal of general physiology 2002;120(6):767-71.
2002: Marc G Coppolino; Renee Doughman; Joost Loijens; Richard F Collins; Mahmoud Pouladi; Jenny Jongstra-Bilen; Alan D Schreiber; William S Trimble; Richard Anderson; Sergio Grinstein
Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis.
The Journal of biological chemistry 2002;277(46):43849-57.
2002: Katalin Szaszi; Anders Paulsen; Elod Z Szabo; Masayuki Numata; Sergio Grinstein; John Orlowski
Clathrin-mediated endocytosis and recycling of the neuron-specific Na+/H+ exchanger NHE5 isoform. Regulation by phosphatidylinositol 3'-kinase and the actin cytoskeleton.
The Journal of biological chemistry 2002;277(45):42623-32.
2002: Hisayoshi Hayashi; Katalin Szászi; Sergio Grinstein
Multiple modes of regulation of Na+/H+ exchangers.
Annals of the New York Academy of Sciences 2002;976():248-58.
2002: Roberto J Botelho; Hans Tapper; Wendy Furuya; Donna Mojdami; Sergio Grinstein
Fc gamma R-mediated phagocytosis stimulates localized pinocytosis in human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(8):4423-9.
2002: Mauricio R Terebiznik; Otilia V Vieira; Sandra L Marcus; Andrea Slade; Christopher M Yip; William S Trimble; Tobias Meyer; B Brett Finlay; Sergio Grinstein
Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by Salmonella.
Nature cell biology 2002;4(10):766-73.
2002: Richard F Collins; Alan D Schreiber; Sergio Grinstein; William S Trimble
Syntaxins 13 and 7 function at distinct steps during phagocytosis.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(6):3250-6.
2002: Otilia V Vieira; Roberto J Botelho; Sergio Grinstein
Phagosome maturation: aging gracefully.
The Biochemical journal 2002;366(Pt 3):689-704.
2002: François Canonne-Hergaux; Jero Calafat; Etienne Richer; Mathieu F M Cellier; Sergio Grinstein; Neils Borregaard; Philippe Gros
Expression and subcellular localization of NRAMP1 in human neutrophil granules.
Blood 2002;100(1):268-75.
2002: Hans Tapper; Wendy Furuya; Sergio Grinstein
Localized exocytosis of primary (lysosomal) granules during phagocytosis: role of Ca2+-dependent tyrosine phosphorylation and microtubules.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(10):5287-96.
2002: Rene E Harrison; Nicolas Touret; Sergio Grinstein
Microbial killing: oxidants, proteases and ions.
Current biology : CB 2002;12(10):R357-9.
2002: Cameron C Scott; Patricia Cuellar-Mata; Tsuyoshi Matsuo; Howard W Davidson; Sergio Grinstein
Role of 3-phosphoinositides in the maturation of Salmonella-containing vacuoles within host cells.
The Journal of biological chemistry 2002;277(15):12770-6.
2002: Claes Nauclér; Sergio Grinstein; Roger Sundler; Hans Tapper
Signaling to localized degranulation in neutrophils adherent to immune complexes.
Journal of leukocyte biology 2002;71(4):701-10.
2002: Hisayoshi Hayashi; Katalin Szászi; Natasha Coady-Osberg; John Orlowski; James L Kinsella; Sergio Grinstein
A slow pH-dependent conformational transition underlies a novel mode of activation of the epithelial Na+/H+ exchanger-3 isoform.
The Journal of biological chemistry 2002;277(13):11090-6.
2002: Andrzej Jankowski; Cameron C Scott; Sergio Grinstein
Determinants of the phagosomal pH in neutrophils.
The Journal of biological chemistry 2002;277(8):6059-66.
2002: Andrzej Jankowski; Sergio Grinstein
Modulation of the cytosolic and phagosomal pH by the NADPH oxidase.
Antioxidants & redox signaling 2002;4(1):61-8.
2002: James W Booth; Moo-Kyung Kim; Andrzej Jankowski; Alan D Schreiber; Sergio Grinstein
Contrasting requirements for ubiquitylation during Fc receptor-mediated endocytosis and phagocytosis.
The EMBO journal 2002;21(3):251-8.
2002: Steven Greenberg; Sergio Grinstein
Phagocytosis and innate immunity.
Current opinion in immunology 2002;14(1):136-45.
2002: Patricia Cuellar-Mata; Nada Jabado; Jun Liu; Wendy Furuya; B Brett Finlay; Philippe Gros; Sergio Grinstein
Nramp1 modifies the fusion of Salmonella typhimurium-containing vacuoles with cellular endomembranes in macrophages.
The Journal of biological chemistry 2002;277(3):2258-65.
2002: Rene E Harrison; Sergio Grinstein
Phagocytosis and the microtubule cytoskeleton.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2002;80(5):509-15.
2001: Andrzej Jankowski; J H Kim; Richard F Collins; R Daneman; P Walton; Sergio Grinstein
In situ measurements of the pH of mammalian peroxisomes using the fluorescent protein pHluorin.
The Journal of biological chemistry 2001;276(52):48748-53.
2001: Marc G Coppolino; M Krause; P Hagendorff; D A Monner; William S Trimble; Sergio Grinstein; Jürgen Wehland; Antonio S Sechi
Evidence for a molecular complex consisting of Fyb/SLAP, SLP-76, Nck, VASP and WASP that links the actin cytoskeleton to Fcgamma receptor signalling during phagocytosis.
Journal of cell science 2001;114(Pt 23):4307-18.
2001: James W Booth; William S Trimble; Sergio Grinstein
Membrane dynamics in phagocytosis.
Seminars in immunology 2001;13(6):357-64.
2001: Katalin Szászi; K Kurashima; K Kaibuchi; Sergio Grinstein; John Orlowski
Role of the cytoskeleton in mediating cAMP-dependent protein kinase inhibition of the epithelial Na+/H+ exchanger NHE3.
The Journal of biological chemistry 2001;276(44):40761-8.
2001: Otilia V Vieira; Roberto J Botelho; Lucia E Rameh; S M Brachmann; Tsuyoshi Matsuo; H W Davidson; A Schreiber; Jonathan M Backer; Lewis C Cantley; Sergio Grinstein
Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation.
The Journal of cell biology 2001;155(1):19-25.
2001: O Aharonovitz; Andras Kapus; Katalin Szászi; Natasha Coady-Osberg; T Jancelewicz; John Orlowski; Sergio Grinstein
Modulation of Na+/H+ exchange activity by Cl-.
American journal of physiology. Cell physiology 2001;281(1):C133-41.
2001: J G Marshall; James W Booth; Vuk Stambolic; Tak Mak; T Balla; Alan D Schreiber; Tobias Meyer; Sergio Grinstein
Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis.
The Journal of cell biology 2001;153(7):1369-80.
2001: D Gillis; Lamara Shrode; E Krump; C M Howard; EA Rubie; L A Tibbles; James R Woodgett; Sergio Grinstein
Osmotic stimulation of the Na+/H+ exchanger NHE1: relationship to the activation of three MAPK pathways.
The Journal of membrane biology 2001;181(3):205-14.
2001: David J Hackam; Roberto J Botelho; C Sjolin; Ori D Rotstein; J M Robinson; Alan D Schreiber; Sergio Grinstein
Indirect role for COPI in the completion of FCgamma receptor-mediated phagocytosis.
The Journal of biological chemistry 2001;276(21):18200-8.
2001: Marc G Coppolino; C Kong; Mahmood Mohtashami; Alan D Schreiber; John H Brumell; B Brett Finlay; Sergio Grinstein; William S Trimble
Requirement for N-ethylmaleimide-sensitive factor activity at different stages of bacterial invasion and phagocytosis.
The Journal of biological chemistry 2001;276(7):4772-80.
2000: Roberto J Botelho; M Teruel; Renee Doughman; R Anderson; A Wells; J D York; Tobias Meyer; Sergio Grinstein
Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis.
The Journal of cell biology 2000;151(7):1353-68.
2000: J Kruger; JR Butler; V Cherapanov; Q Dong; Hedy H Ginzberg; A Govindarajan; Sergio Grinstein; Katherine A Siminovitch; Gregory P Downey
Deficiency of Src homology 2-containing phosphatase 1 results in abnormalities in murine neutrophil function: studies in motheaten mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5847-59.
2000: Nada Jabado; A Jankowski; S Dougaparsad; Virginie Picard; Sergio Grinstein; Philippe Gros
Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane.
The Journal of experimental medicine 2000;192(9):1237-48.
2000: Katalin Szászi; K Kurashima; Andras Kapus; A Paulsen; K Kaibuchi; Sergio Grinstein; John Orlowski
RhoA and rho kinase regulate the epithelial Na+/H+ exchanger NHE3. Role of myosin light chain phosphorylation.
The Journal of biological chemistry 2000;275(37):28599-606.
2000: F B Schapiro; Sergio Grinstein
Determinants of the pH of the Golgi complex.
The Journal of biological chemistry 2000;275(28):21025-32.
2000: O Aharonovitz; H C Zaun; T Balla; J D York; John Orlowski; Sergio Grinstein
Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate.
The Journal of cell biology 2000;150(1):213-24.
2000: Roberto J Botelho; David J Hackam; Alan D Schreiber; Sergio Grinstein
Role of COPI in phagosome maturation.
The Journal of biological chemistry 2000;275(21):15717-27.
2000: L Bajno; Xiao-Rong Peng; Alan D Schreiber; H P Moore; William S Trimble; Sergio Grinstein
Focal exocytosis of VAMP3-containing vesicles at sites of phagosome formation.
The Journal of cell biology 2000;149(3):697-706.
2000: F Schapiro; JJ Sparkowski; A Adduci; Frank A Suprynowicz; Richard Schlegel; Sergio Grinstein
Golgi alkalinization by the papillomavirus E5 oncoprotein.
The Journal of cell biology 2000;148(2):305-15.
2000: Katalin Szászi; Sergio Grinstein; John Orlowski; Andras Kapus
Regulation of the epithelial Na(+) /H(+) exchanger isoform by the cytoskeleton.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2000;10(5-6):265-72.
1999: Chung-Wai Chow; S Khurana; MJ Woodside; Sergio Grinstein; John Orlowski
The epithelial Na(+)/H(+) exchanger, NHE3, is internalized through a clathrin-mediated pathway.
The Journal of biological chemistry 1999;274(53):37551-8.
1999: PJ Plant; Morris F Manolson; Sergio Grinstein; N Demaurex
Alternative mechanisms of vacuolar acidification in H(+)-ATPase-deficient yeast.
The Journal of biological chemistry 1999;274(52):37270-9.
1999: L Bajno; Sergio Grinstein
Fluorescent proteins: powerful tools in phagocyte biology.
Journal of immunological methods 1999;232(1-2):67-75.
1999: J Zhang; C Kong; H Xie; P S McPherson; Sergio Grinstein; William S Trimble
Phosphatidylinositol polyphosphate binding to the mammalian septin H5 is modulated by GTP.
Current biology : CB 1999;9(24):1458-67.
1999: Jinyi Zhang; Amro Shehabeldin; L A da Cruz; J Butler; AK Somani; Mary K H McGavin; Ivona Kozieradzki; A O dos Santos; Andras Nagy; Sergio Grinstein; Josef M Penninger; Katherine A Siminovitch
Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes.
The Journal of experimental medicine 1999;190(9):1329-42.
1999: Bernardo Yusta; Romel Somwar; F Wang; DG Munroe; Sergio Grinstein; Amira Klip; Daniel J Drucker
Identification of glucagon-like peptide-2 (GLP-2)-activated signaling pathways in baby hamster kidney fibroblasts expressing the rat GLP-2 receptor.
The Journal of biological chemistry 1999;274(43):30459-67.
1999: K Kurashima; Sandra D'Souza; Katalin Szászi; R Ramjeesingh; John Orlowski; Sergio Grinstein
The apical Na(+)/H(+) exchanger isoform NHE3 is regulated by the actin cytoskeleton.
The Journal of biological chemistry 1999;274(42):29843-9.
1999: Gregory P Downey; Roberto J Botelho; JR Butler; Yuri Moltyaner; P Chien; Alan D Schreiber; Sergio Grinstein
Phagosomal maturation, acidification, and inhibition of bacterial growth in nonphagocytic cells transfected with FcgammaRIIA receptors.
The Journal of biological chemistry 1999;274(40):28436-44.
1999: Andrzej Jankowski; Sergio Grinstein
A noninvasive fluorimetric procedure for measurement of membrane potential. Quantification of the NADPH oxidase-induced depolarization in activated neutrophils.
The Journal of biological chemistry 1999;274(37):26098-104.
1999: O Aharonovitz; N Demaurex; MJ Woodside; Sergio Grinstein
ATP dependence is not an intrinsic property of Na+/H+ exchanger NHE1: requirement for an ancillary factor.
The American journal of physiology 1999;276(6 Pt 1):C1303-11.
1999: Gregory Govoni; François Canonne-Hergaux; Cheryl G Pfeifer; Sandra L Marcus; Scott David Mills; David J Hackam; Sergio Grinstein; Danielle Malo; B Brett Finlay; Philippe Gros
Functional expression of Nramp1 in vitro in the murine macrophage line RAW264.7.
Infection and immunity 1999;67(5):2225-32.
1999: Chung-Wai Chow; MJ Woodside; N Demaurex; F H Yu; PJ Plant; Daniela Rotin; Sergio Grinstein; John Orlowski
Proline-rich motifs of the Na+/H+ exchanger 2 isoform. Binding of Src homology domain 3 and role in apical targeting in epithelia.
The Journal of biological chemistry 1999;274(15):10481-8.
1999: Samantha Gruenheid; François Canonne-Hergaux; Susan Gauthier; David J Hackam; Sergio Grinstein; Philippe Gros
The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes.
The Journal of experimental medicine 1999;189(5):831-41.
1999: Kevin Petrecca; Roxana Atanasiu; Sergio Grinstein; John Orlowski; Alvin Shrier
Subcellular localization of the Na+/H+ exchanger NHE1 in rat myocardium.
The American journal of physiology 1999;276(2 Pt 2):H709-17.
1998: B S Gan; E Krump; Lamara Shrode; Sergio Grinstein
Loading pyranine via purinergic receptors or hypotonic stress for measurement of cytosolic pH by imaging.
The American journal of physiology 1998;275(4 Pt 1):C1158-66.
1998: David J Hackam; Ori D Rotstein; C Sjolin; Alan D Schreiber; William S Trimble; Sergio Grinstein
v-SNARE-dependent secretion is required for phagocytosis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11691-6.
1998: K Kurashima; E Z Szabó; Gergely L Lukacs; John Orlowski; Sergio Grinstein
Endosomal recycling of the Na+/H+ exchanger NHE3 isoform is regulated by the phosphatidylinositol 3-kinase pathway.
The Journal of biological chemistry 1998;273(33):20828-36.
1998: Lamara Shrode; B S Gan; S J D'Souza; John Orlowski; Sergio Grinstein
Topological analysis of NHE1, the ubiquitous Na+/H+ exchanger using chymotryptic cleavage.
The American journal of physiology 1998;275(2 Pt 1):C431-9.
1998: David J Hackam; Ori D Rotstein; Wei-Jian Zhang; Samantha Gruenheid; Philippe Gros; Sergio Grinstein
Host resistance to intracellular infection: mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification.
The Journal of experimental medicine 1998;188(2):351-64.
1998: J H Kim; Ludger Johannes; Bruno Goud; Claude Antony; Clifford A Lingwood; R Daneman; Sergio Grinstein
Noninvasive measurement of the pH of the endoplasmic reticulum at rest and during calcium release.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(6):2997-3002.
1998: F B Schapiro; Clifford A Lingwood; Wendy Furuya; Sergio Grinstein
pH-independent retrograde targeting of glycolipids to the Golgi complex.
The American journal of physiology 1998;274(2 Pt 1):C319-32.
1998: Sandra D'Souza; A Garcia-Cabado; F Yu; K Teter; Gergely L Lukacs; K Skorecki; Hsiao-Ping H Moore; John Orlowski; Sergio Grinstein
The epithelial sodium-hydrogen antiporter Na+/H+ exchanger 3 accumulates and is functional in recycling endosomes.
The Journal of biological chemistry 1998;273(4):2035-43.
1998: Lamara Shrode; E Krump; Sergio Grinstein
Activation of protein kinases upon volume changes: role in cellular homeostasis.
Contributions to nephrology 1998;123():79-93.
1998: Gregory P Downey; JR Butler; H Tapper; Léa Fialkow; Alan Saltiel; Barry B Rubin; Sergio Grinstein
Importance of MEK in neutrophil microbicidal responsiveness.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(1):434-43.
1997: Gergely L Lukacs; G Segal; Norbert Kartner; Sergio Grinstein; F Zhang
Constitutive internalization of cystic fibrosis transmembrane conductance regulator occurs via clathrin-dependent endocytosis and is regulated by protein phosphorylation.
The Biochemical journal 1997;328 ( Pt 2)():353-61.
1997: David J Hackam; Ori D Rotstein; Wei-Jian Zhang; N Demaurex; MJ Woodside; O Tsai; Sergio Grinstein
Regulation of phagosomal acidification. Differential targeting of Na+/H+ exchangers, Na+/K+-ATPases, and vacuolar-type H+-atpases.
The Journal of biological chemistry 1997;272(47):29810-20.
1997: K Kurashima; F H Yu; A G Cabado; E Z Szabó; Sergio Grinstein; John Orlowski
Identification of sites required for down-regulation of Na+/H+ exchanger NHE3 activity by cAMP-dependent protein kinase. phosphorylation-dependent and -independent mechanisms.
The Journal of biological chemistry 1997;272(45):28672-9.
1997: J Tong; H Oyamada; N Demaurex; Sergio Grinstein; Tommie V McCarthy; David H MacLennan
Caffeine and halothane sensitivity of intracellular Ca2+ release is altered by 15 calcium release channel (ryanodine receptor) mutations associated with malignant hyperthermia and/or central core disease.
The Journal of biological chemistry 1997;272(42):26332-9.
1997: David J Hackam; Ori D Rotstein; A Schreiber; Wei-Jian Zhang; Sergio Grinstein
Rho is required for the initiation of calcium signaling and phagocytosis by Fcgamma receptors in macrophages.
The Journal of experimental medicine 1997;186(6):955-66.
1997: John Orlowski; Sergio Grinstein
Na+/H+ exchangers of mammalian cells.
The Journal of biological chemistry 1997;272(36):22373-6.
1997: Lamara Shrode; Hans Tapper; Sergio Grinstein
Role of intracellular pH in proliferation, transformation, and apoptosis.
Journal of bioenergetics and biomembranes 1997;29(4):393-9.
1997: Chung-Wai Chow; Andras Kapus; RR Romanek; Sergio Grinstein
NO3--induced pH changes in mammalian cells. Evidence for an NO3--H+ cotransporter.
The Journal of general physiology 1997;110(2):185-200.
1997: E Krump; K Nikitas; Sergio Grinstein
Induction of tyrosine phosphorylation and Na+/H+ exchanger activation during shrinkage of human neutrophils.
The Journal of biological chemistry 1997;272(28):17303-11.
1997: AK Sue-A-Quan; Léa Fialkow; chris vlahos; J A Schelm; Sergio Grinstein; J Butler; Gregory P Downey
Inhibition of neutrophil oxidative burst and granule secretion by wortmannin: potential role of MAP kinase and renaturable kinases.
Journal of cellular physiology 1997;172(1):94-108.
1997: Alan P B Dackiw; Sergio Grinstein; G F Brisseau; Ian D McGilvray; A B Nathens; J A McGuire; RR Romanek; P Y Cheung; Ori D Rotstein
The role of tyrosine phosphorylation in lipopolysaccharide- and zymosan-induced procoagulant activity and tissue factor expression in macrophages.
Infection and immunity 1997;65(6):2362-70.
1997: Lamara Shrode; EA Rubie; James R Woodgett; Sergio Grinstein
Cytosolic alkalinization increases stress-activated protein kinase/c-Jun NH2-terminal kinase (SAPK/JNK) activity and p38 mitogen-activated protein kinase activity by a calcium-independent mechanism.
The Journal of biological chemistry 1997;272(21):13653-9.
1997: John H Brumell; KL Craig; D Ferguson; Mike Tyers; Sergio Grinstein
Phosphorylation and subcellular redistribution of pleckstrin in human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4862-71.
1997: Marc G Coppolino; MJ Woodside; N Demaurex; Sergio Grinstein; R St-Arnaud; Shoukat Dedhar
Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion.
Nature 1997;386(6627):843-7.
1997: T Nordström; Lamara Shrode; Ori D Rotstein; RR Romanek; T Goto; Johan N M Heersche; Morris F Manolson; G F Brisseau; Sergio Grinstein
Chronic extracellular acidosis induces plasmalemmal vacuolar type H+ ATPase activity in osteoclasts.
The Journal of biological chemistry 1997;272(10):6354-60.
1997: A Mohamed; D Ferguson; FS Seibert; H M Cai; Norbert Kartner; Sergio Grinstein; John R Riordan; Gergely L Lukacs
Functional expression and apical localization of the cystic fibrosis transmembrane conductance regulator in MDCK I cells.
The Biochemical journal 1997;322 ( Pt 1)():259-65.
1997: N Demaurex; RR Romanek; John Orlowski; Sergio Grinstein
ATP dependence of Na+/H+ exchange. Nucleotide specificity and assessment of the role of phospholipids.
The Journal of general physiology 1997;109(2):117-28.
1997: M Shago; G Flock; Chungyee Leung-Hagesteijn; MJ Woodside; Sergio Grinstein; V Giguère; Shoukat Dedhar
Modulation of the retinoic acid and retinoid X receptor signaling pathways in P19 embryonal carcinoma cells by calreticulin.
Experimental cell research 1997;230(1):50-60.
1997: E Krump; Jasbinder S Sanghera; Steven Pelech; Wendy Furuya; Sergio Grinstein
Chemotactic peptide N-formyl-met-leu-phe activation of p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase-2 in human neutrophils.
The Journal of biological chemistry 1997;272(2):937-44.
1997: John H Brumell; C K Chan; J Butler; N Borregaard; K A Siminovitch; Sergio Grinstein; Gregory P Downey
Regulation of Src homology 2-containing tyrosine phosphatase 1 during activation of human neutrophils. Role of protein kinase C.
The Journal of biological chemistry 1997;272(2):875-82.
1997: MA Robertson; MJ Woodside; J Kevin Foskett; John Orlowski; Sergio Grinstein
Muscarinic agonists induce phosphorylation-independent activation of the NHE-1 isoform of the Na+/H+ antiporter in salivary acinar cells.
The Journal of biological chemistry 1997;272(1):287-94.
1997: Cecil R Pace-Asciak; Denis Reynaud; O Laneuville; Sergio Grinstein; S Nigam
Hepoxilin A3 inhibits agonist-evoked rise in free intracellular calcium in human neutrophils.
Advances in experimental medicine and biology 1997;400A():375-80.
1997: T Tsakiridis; Q Wang; C Taha; Sergio Grinstein; G Downey; Amira Klip
Involvement of the actin network in insulin signalling.
Society of General Physiologists series 1997;52():257-71.
1996: David J Hackam; Sergio Grinstein; Avery B Nathens; W G Watson; John C Marshall; Ori D Rotstein
Exudative neutrophils show impaired pH regulation compared with circulating neutrophils.
Archives of surgery (Chicago, Ill. : 1960) 1996;131(12):1296-301.
1996: J H Kim; Clifford A Lingwood; D B Williams; Wendy Furuya; Morris F Manolson; Sergio Grinstein
Dynamic measurement of the pH of the Golgi complex in living cells using retrograde transport of the verotoxin receptor.
The Journal of cell biology 1996;134(6):1387-99.
1996: Gregory P Downey; J R Butler; John H Brumell; Niels Borregaard; L Kjeldsen; A K Sue-A-Quan; Sergio Grinstein
Chemotactic peptide-induced activation of MEK-2, the predominant isoform in human neutrophils. Inhibition by wortmannin.
The Journal of biological chemistry 1996;271(35):21005-1011.
1996: T Tsakiridis; C Taha; Sergio Grinstein; Amira Klip
Insulin activates a p21-activated kinase in muscle cells via phosphatidylinositol 3-kinase.
The Journal of biological chemistry 1996;271(33):19664-7.
1996: A Nanda; John H Brumell; T Nordström; Lars Kjeldsen; H Sengelov; Niels Borregaard; Ori D Rotstein; Sergio Grinstein
Activation of proton pumping in human neutrophils occurs by exocytosis of vesicles bearing vacuolar-type H+-ATPases.
The Journal of biological chemistry 1996;271(27):15963-70.
1996: N Demaurex; Gregory P Downey; T K Waddell; Sergio Grinstein
Intracellular pH regulation during spreading of human neutrophils.
The Journal of cell biology 1996;133(6):1391-402.
1996: D J Hackam; Ori D Rotstein; M K Bennett; A Klip; Sergio Grinstein; Morris F Manolson
Characterization and subcellular localization of target membrane soluble NSF attachment protein receptors (t-SNAREs) in macrophages. Syntaxins 2, 3, and 4 are present on phagosomal membranes.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(11):4377-83.
1996: G Goss; John Orlowski; Sergio Grinstein
Coimmunoprecipitation of a 24-kDa protein with NHE1, the ubiquitous isoform of the Na+/H+ exchanger.
The American journal of physiology 1996;270(5 Pt 1):C1493-502.
1996: T Fukushima; T K Waddell; Sergio Grinstein; G G Goss; John Orlowski; Gregory P Downey
Na+/H+ exchange activity during phagocytosis in human neutrophils: role of Fcgamma receptors and tyrosine kinases.
The Journal of cell biology 1996;132(6):1037-52.
1996: A G Cabado; F H Yu; Andras Kapus; Gergely L Lukacs; Sergio Grinstein; John Orlowski
Distinct structural domains confer cAMP sensitivity and ATP dependence to the Na+/H+ exchanger NHE3 isoform.
The Journal of biological chemistry 1996;271(7):3590-9.
1996: G F Brisseau; Sergio Grinstein; D J Hackam; T Nordström; Morris F Manolson; A A Khine; Ori D Rotstein
Interleukin-1 increases vacuolar-type H+-ATPase activity in murine peritoneal macrophages.
The Journal of biological chemistry 1996;271(4):2005-11.
1996: John H Brumell; A L Burkhardt; J B Bolen; Sergio Grinstein
Endogenous reactive oxygen intermediates activate tyrosine kinases in human neutrophils.
The Journal of biological chemistry 1996;271(3):1455-61.
1996: David J Hackam; Sergio Grinstein; Ori D Rotstein
Intracellular pH regulation in leukocytes: mechanisms and functional significance.
Shock (Augusta, Ga.) 1996;5(1):17-21.
1995: John H Brumell; Allen Volchuk; H Sengelov; Niels Borregaard; A M Cieutat; DF Bainton; Sergio Grinstein; Amira Klip
Subcellular distribution of docking/fusion proteins in neutrophils, secretory cells with multiple exocytic compartments.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(12):5750-9.
1995: A Nanda; Sergio Grinstein
Chemoattractant-induced activation of vacuolar H+ pumps and of an H(+)-selective conductance in neutrophils.
Journal of cellular physiology 1995;165(3):588-99.
1995: L Bianchini; Andras Kapus; Gergely L Lukacs; S Wasan; S Wakabayashi; Jacques Pouysségur; F H Yu; John Orlowski; Sergio Grinstein
Responsiveness of mutants of NHE1 isoform of Na+/H+ antiport to osmotic stress.
The American journal of physiology 1995;269(4 Pt 1):C998-1007.
1995: N Demaurex; John Orlowski; G Brisseau; MJ Woodside; Sergio Grinstein
The mammalian Na+/H+ antiporters NHE-1, NHE-2, and NHE-3 are electroneutral and voltage independent, but can couple to an H+ conductance.
The Journal of general physiology 1995;106(1):85-111.
1995: Gregory P Downey; Sergio Grinstein; A Sue-A-Quan; B Czaban; Charles K N Chan
Volume regulation in leukocytes: requirement for an intact cytoskeleton.
Journal of cellular physiology 1995;163(1):96-104.
1995: T Nordström; Ori D Rotstein; RR Romanek; S Asotra; Johan N M Heersche; Morris F Manolson; G F Brisseau; Sergio Grinstein
Regulation of cytoplasmic pH in osteoclasts. Contribution of proton pumps and a proton-selective conductance.
The Journal of biological chemistry 1995;270(5):2203-12.
1994: Gergely L Lukacs; A Mohamed; Norbert Kartner; Xiu-Bao Chang; John R Riordan; Sergio Grinstein
Conformational maturation of CFTR but not its mutant counterpart (delta F508) occurs in the endoplasmic reticulum and requires ATP.
The EMBO journal 1994;13(24):6076-86.
1994: Léa Fialkow; Charles K N Chan; D Rotin; Sergio Grinstein; Gregory P Downey
Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. Role of oxidants.
The Journal of biological chemistry 1994;269(49):31234-42.
1994: John H Brumell; Sergio Grinstein
Serine/threonine kinase activation in human neutrophils: relationship to tyrosine phosphorylation.
The American journal of physiology 1994;267(6 Pt 1):C1574-81.
1994: A Nanda; RR Romanek; J T Curnutte; Sergio Grinstein
Assessment of the contribution of the cytochrome b moiety of the NADPH oxidase to the transmembrane H+ conductance of leukocytes.
The Journal of biological chemistry 1994;269(44):27280-5.
1994: N Demaurex; Sergio Grinstein
Na+/H+ antiport: modulation by ATP and role in cell volume regulation.
The Journal of experimental biology 1994;196():389-404.
1994: Sergio Grinstein; H Wieczorek
Cation antiports of animal plasma membranes.
The Journal of experimental biology 1994;196():307-18.
1994: Sergio Grinstein; RR Romanek; Ori D Rotstein
Method for manipulation of cytosolic pH in cells clamped in the whole cell or perforated-patch configurations.
The American journal of physiology 1994;267(4 Pt 1):C1152-9.
1994: Andras Kapus; Sergio Grinstein; S Wasan; R Kandasamy; John Orlowski
Functional characterization of three isoforms of the Na+/H+ exchanger stably expressed in Chinese hamster ovary cells. ATP dependence, osmotic sensitivity, and role in cell proliferation.
The Journal of biological chemistry 1994;269(38):23544-52.
1994: T Nordström; Sergio Grinstein; G F Brisseau; Morris F Manolson; Ori D Rotstein
Protein kinase C activation accelerates proton extrusion by vacuolar-type H(+)-ATPases in murine peritoneal macrophages.
FEBS letters 1994;350(1):82-6.
1994: G F Brisseau; O Tsai; T Nordström; John C Marshall; Sergio Grinstein; Ori D Rotstein
Oxidant stress inhibits pH regulatory mechanisms in murine peritoneal macrophages.
Surgery 1994;116(2):268-74; discussion 274-5.
1994: Sergio Grinstein; J R Butler; Wendy Furuya; G L'Allemain; Gregory P Downey
Chemotactic peptides induce phosphorylation and activation of MEK-1 in human neutrophils.
The Journal of biological chemistry 1994;269(30):19313-20.
1994: L Bianchini; A Nanda; S Wasan; Sergio Grinstein
Activation of multiple pH-regulatory pathways in granulocytes by a phosphotyrosine phosphatase antagonist.
The Biochemical journal 1994;301 ( Pt 2)():539-44.
1994: A Y Qu; A Nanda; J T Curnutte; Sergio Grinstein
Development of a H(+)-selective conductance during granulocytic differentiation of HL-60 cells.
The American journal of physiology 1994;266(5 Pt 1):C1263-70.
1994: Sergio Grinstein; MJ Woodside; G G Goss; Andras Kapus
Osmotic activation of the Na+/H+ antiporter during volume regulation.
Biochemical Society transactions 1994;22(2):512-6.
1994: A Nanda; J T Curnutte; Sergio Grinstein
Activation of H+ conductance in neutrophils requires assembly of components of the respiratory burst oxidase but not its redox function.
The Journal of clinical investigation 1994;93(4):1770-5.
1994: G G Goss; MJ Woodside; S Wakabayashi; J Pouyssegur; T Waddell; Gregory P Downey; Sergio Grinstein
ATP dependence of NHE-1, the ubiquitous isoform of the Na+/H+ antiporter. Analysis of phosphorylation and subcellular localization.
The Journal of biological chemistry 1994;269(12):8741-8.
1994: Andras Kapus; RR Romanek; Sergio Grinstein
Arachidonic acid stimulates the plasma membrane H+ conductance of macrophages.
The Journal of biological chemistry 1994;269(7):4736-45.
1993: Sergio Grinstein; MJ Woodside; T K Waddell; Gregory P Downey; John Orlowski; J Pouyssegur; D C Wong; J Kevin Foskett
Focal localization of the NHE-1 isoform of the Na+/H+ antiport: assessment of effects on intracellular pH.
The EMBO journal 1993;12(13):5209-18.
1993: RR Romanek; R Sargeant; M R Paquet; S Gluck; Amira Klip; Sergio Grinstein
Chloroquine inhibits glucose-transporter recruitment induced by insulin in rat adipocytes independently of its action on endomembrane pH.
The Biochemical journal 1993;296 ( Pt 2)():321-7.
1993: C J Swallow; Sergio Grinstein; R A Sudsbury; Ori D Rotstein
Relative roles of Na+/H+ exchange and vacuolar-type H+ ATPases in regulating cytoplasmic pH and function in murine peritoneal macrophages.
Journal of cellular physiology 1993;157(3):453-60.
1993: Sascha E Dho; Sergio Grinstein; J Kevin Foskett
Plasma membrane recycling in CFTR-expressing CHO cells.
Biochimica et biophysica acta 1993;1225(1):78-82.
1993: R Arellano; Sergio Grinstein
Role of isoprenylation in intracellular pH regulation of granulocytes.
FEBS letters 1993;332(3):247-50.
1993: O Laneuville; Denis Reynaud; Sergio Grinstein; Santosh Nigam; Cecil R Pace-Asciak
Hepoxilin A3 inhibits the rise in free intracellular calcium evoked by formyl-methionyl-leucyl-phenylalanine, platelet-activating factor and leukotriene B4.
The Biochemical journal 1993;295 ( Pt 2)():393-7.
1993: Gergely L Lukacs; Xiu-Bao Chang; Christine E Bear; Norbert Kartner; A Mohamed; John R Riordan; Sergio Grinstein
The delta F508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on transfected cells.
The Journal of biological chemistry 1993;268(29):21592-8.
1993: Andras Kapus; RR Romanek; A Y Qu; Ori D Rotstein; Sergio Grinstein
A pH-sensitive and voltage-dependent proton conductance in the plasma membrane of macrophages.
The Journal of general physiology 1993;102(4):729-60.
1993: Sergio Grinstein; Wendy Furuya; J R Butler; J Tseng
Receptor-mediated activation of multiple serine/threonine kinases in human leukocytes.
The Journal of biological chemistry 1993;268(27):20223-31.
1993: Léa Fialkow; Charles K N Chan; Sergio Grinstein; Gregory P Downey
Regulation of tyrosine phosphorylation in neutrophils by the NADPH oxidase. Role of reactive oxygen intermediates.
The Journal of biological chemistry 1993;268(23):17131-7.
1993: Gergely L Lukacs; Andras Kapus; A Nanda; RR Romanek; Sergio Grinstein
Proton conductance of the plasma membrane: properties, regulation, and functional role.
The American journal of physiology 1993;265(1 Pt 1):C3-14.
1993: Gregory P Downey; A Takai; R Zamel; Sergio Grinstein; Charles K N Chan
Okadaic acid-induced actin assembly in neutrophils: role of protein phosphatases.
Journal of cellular physiology 1993;155(3):505-19.
1993: L Bianchini; G Todderud; Sergio Grinstein
Cytosolic [Ca2+] homeostasis and tyrosine phosphorylation of phospholipase C gamma 2 in HL60 granulocytes.
The Journal of biological chemistry 1993;268(5):3357-63.
1993: A Nanda; Sergio Grinstein; J T Curnutte
Abnormal activation of H+ conductance in NADPH oxidase-defective neutrophils.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(2):760-4.
1993: D J Lu; Wendy Furuya; Sergio Grinstein
Involvement of multiple kinases in neutrophil activation.
Blood cells 1993;19(2):343-9; discussion 349-51.
1992: Sergio Grinstein; MJ Woodside; C Sardet; J Pouyssegur; Daniela Rotin
Activation of the Na+/H+ antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism.
The Journal of biological chemistry 1992;267(33):23823-8.
1992: A Nanda; A Gukovskaya; J Tseng; Sergio Grinstein
Activation of vacuolar-type proton pumps by protein kinase C. Role in neutrophil pH regulation.
The Journal of biological chemistry 1992;267(32):22740-6.
1992: Sergio Grinstein; A Nanda; Gergely L Lukacs; Ori D Rotstein
V-ATPases in phagocytic cells.
The Journal of experimental biology 1992;172():179-92.
1992: C J Swallow; Sergio Grinstein; Ori D Rotstein
Lipopolysaccharide impairs macrophage cytoplasmic pH regulation under conditions simulating the inflammatory microenvironment.
Journal of leukocyte biology 1992;52(4):395-9.
1992: Sergio Grinstein; Wendy Furuya
Chemoattractant-induced tyrosine phosphorylation and activation of microtubule-associated protein kinase in human neutrophils.
The Journal of biological chemistry 1992;267(25):18122-5.
1992: Gergely L Lukacs; Xiu-Bao Chang; Norbert Kartner; Ori D Rotstein; John R Riordan; Sergio Grinstein
The cystic fibrosis transmembrane regulator is present and functional in endosomes. Role as a determinant of endosomal pH.
The Journal of biological chemistry 1992;267(21):14568-72.
1992: Sergio Grinstein; Wendy Furuya; Gregory P Downey
Activation of permeabilized neutrophils: role of anions.
The American journal of physiology 1992;263(1 Pt 1):C78-85.
1992: S Bourgoin; Sergio Grinstein
Peroxides of vanadate induce activation of phospholipase D in HL-60 cells. Role of tyrosine phosphorylation.
The Journal of biological chemistry 1992;267(17):11908-16.
1992: Gregory P Downey; Charles K N Chan; P Lea; A Takai; Sergio Grinstein
Phorbol ester-induced actin assembly in neutrophils: role of protein kinase C.
The Journal of cell biology 1992;116(3):695-706.
1992: D J Lu; A Takai; T L Leto; Sergio Grinstein
Modulation of neutrophil activation by okadaic acid, a protein phosphatase inhibitor.
The American journal of physiology 1992;262(1 Pt 1):C39-49.
1991: Gergely L Lukacs; Ori D Rotstein; Sergio Grinstein
Determinants of the phagosomal pH in macrophages. In situ assessment of vacuolar H(+)-ATPase activity, counterion conductance, and H+ "leak".
The Journal of biological chemistry 1991;266(36):24540-8.
1991: A Nanda; Sergio Grinstein
Protein kinase C activates an H+ (equivalent) conductance in the plasma membrane of human neutrophils.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10816-20.
1991: Michael J Mason; C Garcia-Rodriguez; Sergio Grinstein
Coupling between intracellular Ca2+ stores and the Ca2+ permeability of the plasma membrane. Comparison of the effects of thapsigargin, 2,5-di-(tert-butyl)-1,4-hydroquinone, and cyclopiazonic acid in rat thymic lymphocytes.
The Journal of biological chemistry 1991;266(31):20856-62.
1991: C J Swallow; Sergio Grinstein; R A Sudsbury; Ori D Rotstein
Nitric oxide derived from L-arginine impairs cytoplasmic pH regulation by vacuolar-type H+ ATPases in peritoneal macrophages.
The Journal of experimental medicine 1991;174(5):1009-21.
1991: C J Swallow; Sergio Grinstein; R A Sudsbury; Ori D Rotstein
Cytoplasmic pH regulation in monocytes and macrophages: mechanisms and functional implications.
Clinical and investigative medicine. Médecine clinique et experimentale 1991;14(5):367-78.
1991: Gergely L Lukacs; A Nanda; Ori D Rotstein; Sergio Grinstein
The chloride channel blocker 5-nitro-2-(3-phenylpropyl-amino) benzoic acid (NPPB) uncouples mitochondria and increases the proton permeability of the plasma membrane in phagocytic cells.
FEBS letters 1991;288(1-2):17-20.
1991: L Bianchini; MJ Woodside; C Sardet; J Pouyssegur; A Takai; Sergio Grinstein
Okadaic acid, a phosphatase inhibitor, induces activation and phosphorylation of the Na+/H+ antiport.
The Journal of biological chemistry 1991;266(23):15406-13.
1991: Michael J Mason; Martyn P Mahaut-Smith; Sergio Grinstein
The role of intracellular Ca2+ in the regulation of the plasma membrane Ca2+ permeability of unstimulated rat lymphocytes.
The Journal of biological chemistry 1991;266(17):10872-9.
1991: S Trudel; M R Pâquet; Sergio Grinstein
Mechanism of vanadate-induced activation of tyrosine phosphorylation and of the respiratory burst in HL60 cells. Role of reduced oxygen metabolites.
The Biochemical journal 1991;276 ( Pt 3)():611-9.
1991: Sergio Grinstein; C J Swallow; Ori D Rotstein
Regulation of cytoplasmic pH in phagocytic cell function and dysfunction.
Clinical biochemistry 1991;24(3):241-7.
1991: Sergio Grinstein; Wendy Furuya
Tyrosine phosphorylation and oxygen consumption induced by G proteins in neutrophils.
The American journal of physiology 1991;260(5 Pt 1):C1019-27.
1990: Gergely L Lukacs; Ori D Rotstein; Sergio Grinstein
Phagosomal acidification is mediated by a vacuolar-type H(+)-ATPase in murine macrophages.
The Journal of biological chemistry 1990;265(34):21099-107.
1990: D J Lu; Sergio Grinstein
ATP and guanine nucleotide dependence of neutrophil activation. Evidence for the involvement of two distinct GTP-binding proteins.
The Journal of biological chemistry 1990;265(23):13721-9.
1990: C J Swallow; Sergio Grinstein; R A Sudsbury; Ori D Rotstein
Modulation of the macrophage respiratory burst by an acidic environment: the critical role of cytoplasmic pH regulation by proton extrusion pumps.
Surgery 1990;108(2):363-8; discussion 368-9.
1990: S Trudel; Gregory P Downey; Sergio Grinstein; M R Pâquet
Activation of permeabilized HL60 cells by vanadate. Evidence for divergent signalling pathways.
The Biochemical journal 1990;269(1):127-31.
1990: Michael J Mason; Sergio Grinstein
Effect of cytoplasmic acidification on the membrane potential of T-lymphocytes: role of trace metals.
The Journal of membrane biology 1990;116(2):139-48.
1990: Gregory P Downey; Charles K N Chan; S Trudel; Sergio Grinstein
Actin assembly in electropermeabilized neutrophils: role of intracellular calcium.
The Journal of cell biology 1990;110(6):1975-82.
1990: C J Swallow; Sergio Grinstein; Ori D Rotstein
A vacuolar type H(+)-ATPase regulates cytoplasmic pH in murine macrophages.
The Journal of biological chemistry 1990;265(13):7645-54.
1990: C J Swallow; Sergio Grinstein; Ori D Rotstein
Regulation of cytoplasmic pH in resident and activated peritoneal macrophages.
Biochimica et biophysica acta 1990;1022(2):203-10.
1990: Sascha E Dho; Sergio Grinstein; EJ Corey; W G Su; Cecil R Pace-Asciak
Hepoxilin A3 induces changes in cytosolic calcium, intracellular pH and membrane potential in human neutrophils.
The Biochemical journal 1990;266(1):63-8.
1990: Sergio Grinstein; Wendy Furuya; D J Lu; Gordon B Mills
Vanadate stimulates oxygen consumption and tyrosine phosphorylation in electropermeabilized human neutrophils.
The Journal of biological chemistry 1990;265(1):318-27.
1990: Sergio Grinstein; J D Smith
Calcium-independent cell volume regulation in human lymphocytes. Inhibition by charybdotoxin.
The Journal of general physiology 1990;95(1):97-120.
1989: Daniela Rotin; Sergio Grinstein
Impaired cell volume regulation in Na(+)-H+ exchange-deficient mutants.
The American journal of physiology 1989;257(6 Pt 1):C1158-65.
1989: D J Lu; Sergio Grinstein
Concanavalin A stimulation of O2 consumption in electropermeabilized neutrophils via a pertussis toxin-insensitive G protein.
FEBS letters 1989;253(1-2):151-6.
1989: Sergio Grinstein; M Hill; Wendy Furuya
Activation of electropermeabilized neutrophils by adenosine 5'-[gamma-thio]triphosphate (ATP[S]). Role of phosphatases in stimulus-response coupling.
The Biochemical journal 1989;261(3):755-9.
1989: Sergio Grinstein; J D Smith
Ca2+ induces charybdotoxin-sensitive membrane potential changes in rat lymphocytes.
The American journal of physiology 1989;257(2 Pt 1):C197-206.
1989: C J Swallow; Ori D Rotstein; Sergio Grinstein
Mechanisms of cytoplasmic pH recovery in acid-loaded macrophages.
The Journal of surgical research 1989;46(6):588-92.
1989: P Nasmith; Sergio Grinstein
Diacylglycerol kinase inhibitors R59022 and dioctanoylethylene glycol potentiate the respiratory burst of neutrophils by raising cytosolic Ca2+.
Biochemical and biophysical research communications 1989;161(1):95-100.
1989: Ori D Rotstein; T Vittorini; J Kao; Mike I McBurney; P E Nasmith; Sergio Grinstein
A soluble Bacteroides by-product impairs phagocytic killing of Escherichia coli by neutrophils.
Infection and immunity 1989;57(3):745-53.
1989: P E Nasmith; Gordon B Mills; Sergio Grinstein
Guanine nucleotides induce tyrosine phosphorylation and activation of the respiratory burst in neutrophils.
The Biochemical journal 1989;257(3):893-7.
1989: Michael J Mason; J D Smith; J J Garcia-Soto; Sergio Grinstein
Internal pH-sensitive site couples Cl-(-)HCO3- exchange to Na+-H+ antiport in lymphocytes.
The American journal of physiology 1989;256(2 Pt 1):C428-33.
1989: Sergio Grinstein; Daniela Rotin; Michael J Mason
Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation.
Biochimica et biophysica acta 1989;988(1):73-97.
1988: C J Swallow; Sergio Grinstein; Ori D Rotstein
Cytoplasmic pH regulation in macrophages by an ATP-dependent and N,N'-dicyclohexylcarbodiimide-sensitive mechanism. Possible involvement of a plasma membrane proton pump.
The Journal of biological chemistry 1988;263(36):19558-63.
1988: Roy K Cheung; Sergio Grinstein; Erwin W Gelfand
Mitogenic and non-mitogenic ligands trigger a calcium-dependent cytosolic acidification in human T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(5):1648-51.
1988: Ori D Rotstein; P E Nasmith; Sergio Grinstein
pH-dependent impairment of the neutrophil respiratory burst by the Bacteroides byproduct succinate.
Clinical and investigative medicine. Médecine clinique et experimentale 1988;11(4):259-65.
1988: S L MacDougall; Sergio Grinstein; Erwin W Gelfand
Detection of ligand-activated conductive Ca2+ channels in human B lymphocytes.
Cell 1988;54(2):229-34.
1988: Sergio Grinstein; J D Smith; R Onizuka; Roy K Cheung; E W Gelfand; S Benedict
Activation of Na+/H+ exchange and the expression of cellular proto-oncogenes in mitogen- and phorbol ester-treated lymphocytes.
The Journal of biological chemistry 1988;263(18):8658-65.
1988: Sergio Grinstein; Wendy Furuya
Receptor-mediated activation of electropermeabilized neutrophils. Evidence for a Ca2+- and protein kinase C-independent signaling pathway.
The Journal of biological chemistry 1988;263(4):1779-83.
1988: P E Nasmith; Sergio Grinstein
Cytosolic calcium, oxygen consumption and the intracellular pH of stimulated neutrophils.
Bioscience reports 1988;8(1):65-76.
1988: Sergio Grinstein; Wendy Furuya
Assessment of Na+-H+ exchange activity in phagosomal membranes of human neutrophils.
The American journal of physiology 1988;254(2 Pt 1):C272-85.
1988: S L MacDougall; Sergio Grinstein; Erwin W Gelfand
Activation of Ca2+-dependent K+ channels in human B lymphocytes by anti-immunoglobulin.
The Journal of clinical investigation 1988;81(2):449-54.
1988: Erwin W Gelfand; Roy K Cheung; Sergio Grinstein
Calcium-dependent intracellular acidification dominates the pH response to mitogen in human T cells.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(1):246-52.
1988: Sergio Grinstein; Wendy Furuya; P E Nasmith; Ori D Rotstein
Na+/H+ exchange and the regulation of intracellular pH in polymorphonuclear leukocytes.
Comparative biochemistry and physiology. A, Comparative physiology 1988;90(4):543-9.
1988: Sergio Grinstein; Wendy Furuya; Ori D Rotstein
Intracellular pH regulation in neutrophils: properties and distribution of the Na+/H+ antiporter.
Society of General Physiologists series 1988;43():303-14.
1988: Sergio Grinstein; J Garcia-Soto; Michael J Mason
Differential role of cation and anion exchange in lymphocyte pH regulation.
Ciba Foundation symposium 1988;139():70-86.
1987: A Livne; Sergio Grinstein; A Rothstein
Characterization of Na+/H+ exchange in platelets.
Thrombosis and haemostasis 1987;58(4):971-7.
1987: Chaim M Roifman; Gordon B Mills; D Stewart; Roy K Cheung; Sergio Grinstein; Erwin W Gelfand
Response of human B cells to different anti-immunoglobulin isotypes: absence of a correlation between early activation events and cell proliferation.
European journal of immunology 1987;17(12):1737-42.
1987: Sergio Grinstein; J D Smith; C Rowatt; S J Dixon
Mechanism of activation of lymphocyte Na+/H+ exchange by concanavalin A. A calcium- and protein kinase C-independent pathway.
The Journal of biological chemistry 1987;262(31):15277-84.
1987: P E Nasmith; Sergio Grinstein
Phorbol ester-induced changes in cytoplasmic Ca2+ in human neutrophils. Involvement of a pertussis toxin-sensitive G protein.
The Journal of biological chemistry 1987;262(28):13558-66.
1987: S J Dixon; D Stewart; Sergio Grinstein; S Spiegel
Transmembrane signaling by the B subunit of cholera toxin: increased cytoplasmic free calcium in rat lymphocytes.
The Journal of cell biology 1987;105(3):1153-61.
1987: Sergio Grinstein; J D Goetz-Smith; S Cohen
Cytoplasmic free Ca2+ and the intracellular pH of lymphocytes.
Society of General Physiologists series 1987;42():215-28.