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Alan Grodzinsky

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TOP 3
Hadi Tavakoli Nia; Christine Ortiz; Kamal Youcef-Toumi; Iman S Bozchalooi; Eliot Frank; Lin Han; Han-Hwa Hung; Yang Li; Alan J Grodzinsky
High-Bandwidth AFM-Based Rheology Reveals that Cartilage is Most Sensitive to High Loading Rates at Early Stages of Impairment.
Sangwon Byun; Eliot H Frank; Ernst B Hunziker; Karl Kavalkovich; Yihong C S Lu; Tatiana Ort; Yunna L Sinskey; Pitchumani Sivakumar; Alan J Grodzinsky
Transport of anti-IL-6 antigen binding fragments into cartilage and the effects of injury.
Hsu-Yi Lee; Alan J Grodzinsky; Lin Han; Peter J Roughley; Christine Ortiz
Age-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains.

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2013: Hadi Tavakoli Nia; Christine Ortiz; Kamal Youcef-Toumi; Iman S Bozchalooi; Eliot Frank; Lin Han; Han-Hwa Hung; Yang Li; Alan J Grodzinsky
High-Bandwidth AFM-Based Rheology Reveals that Cartilage is Most Sensitive to High Loading Rates at Early Stages of Impairment.
Biophysical journal 2013;104(7):1529-37.
2013: Sangwon Byun; Eliot H Frank; Ernst B Hunziker; Karl Kavalkovich; Yihong C S Lu; Tatiana Ort; Yunna L Sinskey; Pitchumani Sivakumar; Alan J Grodzinsky
Transport of anti-IL-6 antigen binding fragments into cartilage and the effects of injury.
Archives of biochemistry and biophysics 2013;532(1):15-22.
2013: Hsu-Yi Lee; Alan J Grodzinsky; Lin Han; Peter J Roughley; Christine Ortiz
Age-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains.
Journal of structural biology 2013;181(3):264-73.
2013: Christina M Lee; C Wayne McIlwraith; Alan J Grodzinsky; John Kisiday; David D Frisbie
Synoviocytes protect cartilage from the effects of injury in vitro.
BMC musculoskeletal disorders 2013;14():54.
2013: Christina M Lee; Wayne McIlwraith; Alan J Grodzinsky; John Kisiday; David D Frisbie
Development of an in vitro model of injury-induced osteoarthritis in cartilage explants from adult horses through application of single-impact compressive overload.
American journal of veterinary research 2013;74(1):40-7.
2013: M Hufeland; J Imgenberg; Alan J Grodzinsky; Michael Schünke; Bodo Kurz
Response of mature meniscal tissue to a single injurious compression and interleukin-1 in vitro.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2013;21(1):209-16.
2012: Andrew C Ahn; Brian J Gow; Alan J Grodzinsky; Orjan G Martinsen; Min Zhao; Iain D Baikie
Applying the Kelvin probe to biological tissues: theoretical and computational analyses.
Physical review. E, Statistical, nonlinear, and soft matter physics 2012;85(6 Pt 1):061901.
2011: Rachel E Miller; Paul W Kopesky; Alan J Grodzinsky
Growth factor delivery through self-assembling peptide scaffolds.
Clinical orthopaedics and related research 2011;469(10):2716-24.
2011: Lin Han; Eliot H Frank; Jacqueline J Greene; Hsu-Yi Lee; Han-Hwa Hung; Alan J Grodzinsky; Christine Ortiz
Time-dependent nanomechanics of cartilage.
Biophysical journal 2011;100(7):1846-54.
2011: Bruce S Gardiner; Peter Pivonka; David W Smith; Lihai Zhang; Alan J Grodzinsky
A mathematical model for targeting chemicals to tissues by exploiting complex degradation.
Biology direct 2011;6():46.
2011: Yihong C S Lu; Christopher H Evans; Alan J Grodzinsky
Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines.
Arthritis research & therapy 2011;13(5):R142.
2011: Paul W Kopesky; Eric J Vanderploeg; John Kisiday; David D Frisbie; John D Sandy; Alan J Grodzinsky
Controlled delivery of transforming growth factor β1 by self-assembling peptide hydrogels induces chondrogenesis of bone marrow stromal cells and modulates Smad2/3 signaling.
Tissue engineering. Part A 2011;17(1-2):83-92.
2010: Rachel E Miller; Alan J Grodzinsky; E J Vanderploeg; C Lee; D J Ferris; M F Barrett; John Kisiday; David D Frisbie
Effect of self-assembling peptide, chondrogenic factors, and bone marrow-derived stromal cells on osteochondral repair.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2010;18(12):1608-19.
2010: Rachel E Miller; Alan J Grodzinsky; Kiersten Cummings; Anna Plaas; Ada A Cole; Richard T Lee; Parth Patwari
Intraarticular injection of heparin-binding insulin-like growth factor 1 sustains delivery of insulin-like growth factor 1 to cartilage through binding to chondroitin sulfate.
Arthritis and rheumatism 2010;62(12):3686-94.
2010: Ha Youn Lee; P W Kopesky; Anna Plaas; J Sandy; John Kisiday; David D Frisbie; Alan J Grodzinsky; Christine Ortiz
Adult bone marrow stromal cell-based tissue-engineered aggrecan exhibits ultrastructure and nanomechanical properties superior to native cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2010;18(11):1477-86.
2010: Bernd Rolauffs; Carol Muehleman; Jun Li; Bodo Kurz; Klaus E Kuettner; Eliot Frank; Alan J Grodzinsky
Vulnerability of the superficial zone of immature articular cartilage to compressive injury.
Arthritis and rheumatism 2010;62(10):3016-27.
2010: Sangwon Byun; Micky D Tortorella; Anne-Marie Malfait; Kam Fok; Eliot H Frank; Alan J Grodzinsky
Transport and equilibrium uptake of a peptide inhibitor of PACE4 into articular cartilage is dominated by electrostatic interactions.
Archives of biochemistry and biophysics 2010;499(1-2):32-9.
2010: P W Kopesky; H-Y Lee; E J Vanderploeg; John Kisiday; David D Frisbie; Anna Plaas; Christine Ortiz; Alan J Grodzinsky
Adult equine bone marrow stromal cells produce a cartilage-like ECM mechanically superior to animal-matched adult chondrocytes.
Matrix biology : journal of the International Society for Matrix Biology 2010;29(5):427-38.
2010: Angelika K Lemke; John D Sandy; Henning Voigt; Rita Dreier; Jennifer H Lee; Alan J Grodzinsky; Rolf Mentlein; Jakob Fay; Michael Schünke; Bodo Kurz
Interleukin-1alpha treatment of meniscal explants stimulates the production and release of aggrecanase-generated, GAG-substituted aggrecan products and also the release of pre-formed, aggrecanase-generated G1 and m-calpain-generated G1-G2.
Cell and tissue research 2010;340(1):179-88.
2010: Bobae Lee; Lin Han; Eliot H Frank; Susan Chubinskaya; Christine Ortiz; Alan J Grodzinsky
Dynamic mechanical properties of the tissue-engineered matrix associated with individual chondrocytes.
Journal of biomechanics 2010;43(3):469-76.
2010: Bernd Rolauffs; James M Williams; Matthias Aurich; Alan J Grodzinsky; Klaus E Kuettner; Ada A Cole
Proliferative remodeling of the spatial organization of human superficial chondrocytes distant from focal early osteoarthritis.
Arthritis and rheumatism 2010;62(2):489-98.
2010: D H Chai; Elizabeth C Arner; D W Griggs; Alan J Grodzinsky
Alphav and beta1 integrins regulate dynamic compression-induced proteoglycan synthesis in 3D gel culture by distinct complementary pathways.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2010;18(2):249-56.
2010: Paul W Kopesky; Eric J Vanderploeg; John S Sandy; Bodo Kurz; Alan J Grodzinsky
Self-assembling peptide hydrogels modulate in vitro chondrogenesis of bovine bone marrow stromal cells.
Tissue engineering. Part A 2010;16(2):465-77.
2009: Yihong Sui; Jennifer H Lee; Michael A DiMicco; Eric J Vanderploeg; Simon M Blake; Han-Hwa Hung; Anna Plaas; Ian E James; Xiao-Yu Song; Michael W Lark; Alan J Grodzinsky
Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage.
Arthritis and rheumatism 2009;60(10):2985-96.
2009: J H Lee; Jonathan B Fitzgerald; Michael A DiMicco; D M Cheng; C R Flannery; John D Sandy; Anna Plaas; Alan J Grodzinsky
Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production.
Archives of biochemistry and biophysics 2009;489(1-2):118-26.
2009: Andrew C Ahn; Alan J Grodzinsky
Relevance of collagen piezoelectricity to "Wolff's Law": a critical review.
Medical engineering & physics 2009;31(7):733-41.
2009: Parth Patwari; S N Lin; Bodo Kurz; Ada A Cole; Sanjay Kumar; Alan J Grodzinsky
Potent inhibition of cartilage biosynthesis by coincubation with joint capsule through an IL-1-independent pathway.
Scandinavian journal of medicine & science in sports 2009;19(4):528-35.
2009: John Kisiday; Jennifer H Lee; Patrick N Siparsky; David D Frisbie; Carl R Flannery; John D Sandy; Alan J Grodzinsky
Catabolic responses of chondrocyte-seeded peptide hydrogel to dynamic compression.
Annals of biomedical engineering 2009;37(7):1368-75.
2009: C A Wheeler; S R Jafarzadeh; David Rocke; Alan J Grodzinsky
IGF-1 does not moderate the time-dependent transcriptional patterns of key homeostatic genes induced by sustained compression of bovine cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2009;17(7):944-52.
2009: Anna L Stevens; John S Wishnok; Forest M White; Alan J Grodzinsky; Steven R Tannenbaum
Mechanical injury and cytokines cause loss of cartilage integrity and upregulate proteins associated with catabolism, immunity, inflammation, and repair.
Molecular & cellular proteomics : MCP 2009;8(7):1475-89.
2008: Lin Han; Delphine Dean; Laura A Daher; Alan J Grodzinsky; Christine Ortiz
Cartilage aggrecan can undergo self-adhesion.
Biophysical journal 2008;95(10):4862-70.
2008: E Pfeiffer; Scott Vickers; E Frank; Alan J Grodzinsky; Myron Spector
The effects of glycosaminoglycan content on the compressive modulus of cartilage engineered in type II collagen scaffolds.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(10):1237-44.
2008: Zhen Lin; Jonathan B Fitzgerald; Jiake Xu; Craig Willers; David Wood; Alan J Grodzinsky; Ming H Zheng
Gene expression profiles of human chondrocytes during passaged monolayer cultivation.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2008;26(9):1230-7.
2008: Tomotake Tokunou; Rachel E Miller; Parth Patwari; Michael E Davis; Vincent F M Segers; Alan J Grodzinsky; Richard T Lee
Engineering insulin-like growth factor-1 for local delivery.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(6):1886-93.
2008: Bernd Rolauffs; James M Williams; Alan J Grodzinsky; Klaus E Kuettner; Ada A Cole
Distinct horizontal patterns in the spatial organization of superficial zone chondrocytes of human joints.
Journal of structural biology 2008;162(2):335-44.
2008: A L Stevens; C A Wheeler; Steven R Tannenbaum; Alan J Grodzinsky
Nitric oxide enhances aggrecan degradation by aggrecanase in response to TNF-alpha but not IL-1beta treatment at a post-transcriptional level in bovine cartilage explants.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(4):489-97.
2008: Jonathan B Fitzgerald; Moonsoo Jin; Diana H Chai; Patrick Siparsky; Paul Fanning; Alan J Grodzinsky
Shear- and compression-induced chondrocyte transcription requires MAPK activation in cartilage explants.
The Journal of biological chemistry 2008;283(11):6735-43.
2008: Anna L Stevens; John S Wishnok; Diana H Chai; Alan J Grodzinsky; Steven R Tannenbaum
A sodium dodecyl sulfate-polyacrylamide gel electrophoresis-liquid chromatography tandem mass spectrometry analysis of bovine cartilage tissue response to mechanical compression injury and the inflammatory cytokines tumor necrosis factor alpha and interleukin-1beta.
Arthritis and rheumatism 2008;58(2):489-500.
2007: Michael A DiMicco; John Kisiday; H Gong; Alan J Grodzinsky
Structure of pericellular matrix around agarose-embedded chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2007;15(10):1207-16.
2007: Lin Han; Delphine Dean; Pan Mao; Christine Ortiz; Alan J Grodzinsky
Nanoscale shear deformation mechanisms of opposing cartilage aggrecan macromolecules.
Biophysical journal 2007;93(5):L23-5.
2007: Lin Han; Delphine Dean; Christine Ortiz; Alan J Grodzinsky
Lateral nanomechanics of cartilage aggrecan macromolecules.
Biophysical journal 2007;92(4):1384-98.
2007: Laurel Ng; Han-Hwa Hung; Alexander Sprunt; Susan Chubinskaya; Christine Ortiz; Alan J Grodzinsky
Nanomechanical properties of individual chondrocytes and their developing growth factor-stimulated pericellular matrix.
Journal of biomechanics 2007;40(5):1011-23.
2007: Parth Patwari; Debbie M Cheng; Ada A Cole; Klaus E Kuettner; Alan J Grodzinsky
Analysis of the relationship between peak stress and proteoglycan loss following injurious compression of human post-mortem knee and ankle cartilage.
Biomechanics and modeling in mechanobiology 2007;6(1-2):83-9.
2006: Aruna K Behera; Ethan Hildebrand; Jon Szafranski; Han-Hwa Hung; Alan J Grodzinsky; Robert Lafyatis; Alisa E Koch; Robert Kalish; George Perides; Allen C Steere; Linden T Hu
Role of aggrecanase 1 in Lyme arthritis.
Arthritis and rheumatism 2006;54(10):3319-29.
2006: Jonathan B Fitzgerald; Moonsoo Jin; Alan J Grodzinsky
Shear and compression differentially regulate clusters of functionally related temporal transcription patterns in cartilage tissue.
The Journal of biological chemistry 2006;281(34):24095-103.
2006: Delphine Dean; Lin Han; Alan J Grodzinsky; Christine Ortiz
Compressive nanomechanics of opposing aggrecan macromolecules.
Journal of biomechanics 2006;39(14):2555-65.
2005: Bodo Kurz; Angelika Lemke; Jakob Fay; Thomas Pufe; Alan J Grodzinsky; Michael Schünke
Pathomechanisms of cartilage destruction by mechanical injury.
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2005;187(5-6):473-85.
2005: Mark Bathe; Gregory C Rutledge; Alan J Grodzinsky; Bruce Tidor
Osmotic pressure of aqueous chondroitin sulfate solution: a molecular modeling investigation.
Biophysical journal 2005;89(4):2357-71.
2005: Joonil Seog; Delphine Dean; Bernd Rolauffs; Tao Wu; Jan Genzer; Anna Plaas; Alan J Grodzinsky; Christine Ortiz
Nanomechanics of opposing glycosaminoglycan macromolecules.
Journal of biomechanics 2005;38(9):1789-97.
2005: Jennifer H Lee; Jonathan B Fitzgerald; Michael A DiMicco; Alan J Grodzinsky
Mechanical injury of cartilage explants causes specific time-dependent changes in chondrocyte gene expression.
Arthritis and rheumatism 2005;52(8):2386-95.
2005: Mark Bathe; Gregory C Rutledge; Alan J Grodzinsky; Bruce Tidor
A coarse-grained molecular model for glycosaminoglycans: application to chondroitin, chondroitin sulfate, and hyaluronic acid.
Biophysical journal 2005;88(6):3870-87.
2005: Parth Patwari; G Gao; J H Lee; Alan J Grodzinsky; John D Sandy
Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2005;13(4):269-77.
2005: John Kisiday; Bodo Kurz; Michael A DiMicco; Alan J Grodzinsky
Evaluation of medium supplemented with insulin-transferrin-selenium for culture of primary bovine calf chondrocytes in three-dimensional hydrogel scaffolds.
Tissue engineering 2005;11(1-2):141-51.
2004: Jon D Szafranski; Alan J Grodzinsky; Elke Burger; Veronique Gaschen; Han-Hwa Hung; Ernst B Hunziker
Chondrocyte mechanotransduction: effects of compression on deformation of intracellular organelles and relevance to cellular biosynthesis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2004;12(12):937-46.
2004: Mark Bathe; Alan J Grodzinsky; Bruce Tidor; Gregory C Rutledge
Optimal linearized Poisson-Boltzmann theory applied to the simulation of flexible polyelectrolytes in solution.
The Journal of chemical physics 2004;121(16):7557-61.
2004: Tim A Wagner; Markus Zahn; Alan J Grodzinsky; Alvaro Pascual-Leone
Three-dimensional head model simulation of transcranial magnetic stimulation.
IEEE transactions on bio-medical engineering 2004;51(9):1586-98.
2004: Jonathan B Fitzgerald; Moonsoo Jin; Delphine Dean; David J Wood; Ming H Zheng; Alan J Grodzinsky
Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP.
The Journal of biological chemistry 2004;279(19):19502-11.
2004: John Kisiday; Moonsoo Jin; Michael A DiMicco; Bodo Kurz; Alan J Grodzinsky
Effects of dynamic compressive loading on chondrocyte biosynthesis in self-assembling peptide scaffolds.
Journal of biomechanics 2004;37(5):595-604.
2004: Michael A DiMicco; Parth Patwari; Patrick N Siparsky; Sanjay Kumar; Michael A Pratta; Michael W Lark; Young-Jo Kim; Alan J Grodzinsky
Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury.
Arthritis and rheumatism 2004;50(3):840-8.
2004: Parth Patwari; Veronique Gaschen; Ian E James; E Berger; Simon M Blake; Michael W Lark; Alan J Grodzinsky; Ernst B Hunziker
Ultrastructural quantification of cell death after injurious compression of bovine calf articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2004;12(3):245-52.
2004: Jean-Noel Gouze; Elvire Gouze; Glyn D Palmer; H Kaneto; Steven C Ghivizzani; Alan J Grodzinsky; Christopher H Evans
Adenovirus-mediated gene transfer of glutamine: fructose-6-phosphate amidotransferase antagonizes the effects of interleukin-1beta on rat chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2004;12(3):217-24.
2004: Eliot H Frank; R Evans; C Lee; S Treppo; Myron Spector; Alan J Grodzinsky
Quantitative electrical impedance analysis of cartilage degradation.
Biorheology 2004;41(3-4):195-202.
2004: Jean-Noel Gouze; Martin Stoddart; Elvire Gouze; Glyn D Palmer; Steven C Ghivizzani; Alan J Grodzinsky; Christopher H Evans
In vitro gene transfer to chondrocytes and synovial fibroblasts by adenoviral vectors.
Methods in molecular medicine 2004;100():147-64.
2004: John Kisiday; Alex Kerin; Alan J Grodzinsky
Mechanical testing of cell-material constructs: a review.
Methods in molecular biology (Clifton, N.J.) 2004;238():239-54.
2004: Bodo Kurz; Angelika Lemke; Melanie Kehn; Christian Domm; Parth Patwari; Eliot H Frank; Alan J Grodzinsky; Michael Schünke
Influence of tissue maturation and antioxidants on the apoptotic response of articular cartilage after injurious compression.
Arthritis and rheumatism 2004;50(1):123-30.
2004: Thomas Pufe; Angelika Lemke; Bodo Kurz; Wolf Petersen; Bernhard Tillmann; Alan J Grodzinsky; Rolf Mentlein
Mechanical overload induces VEGF in cartilage discs via hypoxia-inducible factor.
The American journal of pathology 2004;164(1):185-92.
2003: Paul J Fanning; Gregory Emkey; Robert J Smith; Alan J Grodzinsky; Nora Szasz; Stephen B Trippel
Mechanical regulation of mitogen-activated protein kinase signaling in articular cartilage.
The Journal of biological chemistry 2003;278(51):50940-8.
2003: Laurel Ng; Alan J Grodzinsky; Parth Patwari; John Sandy; Anna Plaas; Christine Ortiz
Individual cartilage aggrecan macromolecules and their constituent glycosaminoglycans visualized via atomic force microscopy.
Journal of structural biology 2003;143(3):242-57.
2003: A Minerva Garcia; Nora Szasz; Stephen B Trippel; Teresa I Morales; Alan J Grodzinsky; Eliot H Frank
Transport and binding of insulin-like growth factor I through articular cartilage.
Archives of biochemistry and biophysics 2003;415(1):69-79.
2003: Moonsoo Jin; Greg R Emkey; Patrick N Siparsky; Stephen B Trippel; Alan J Grodzinsky
Combined effects of dynamic tissue shear deformation and insulin-like growth factor I on chondrocyte biosynthesis in cartilage explants.
Archives of biochemistry and biophysics 2003;414(2):223-31.
2003: Parth Patwari; Michael N Cook; Michael A DiMicco; Simon M Blake; Ian E James; Sanjay Kumar; Ada A Cole; Michael W Lark; Alan J Grodzinsky
Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines.
Arthritis and rheumatism 2003;48(5):1292-301.
2003: CR Lee; Alan J Grodzinsky; Myron Spector
Biosynthetic response of passaged chondrocytes in a type II collagen scaffold to mechanical compression.
Journal of biomedical materials research. Part A 2003;64(3):560-9.
2003: CR Lee; Alan J Grodzinsky; HP Hsu; Myron Spector
Effects of a cultured autologous chondrocyte-seeded type II collagen scaffold on the healing of a chondral defect in a canine model.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2003;21(2):272-81.
2003: C R Lee; Alan J Grodzinsky; Myron Spector
Modulation of the contractile and biosynthetic activity of chondrocytes seeded in collagen-glycosaminoglycan matrices.
Tissue engineering 2003;9(1):27-36.
2003: Jean-Noel Gouze; Elvire Gouze; Glyn D Palmer; Victor S Liew; Arnulf Pascher; Oliver Betz; Thomas S Thornhill; Christopher H Evans; Alan J Grodzinsky; Steven C Ghivizzani
A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer.
Arthritis research & therapy 2003;5(5):R301-9.
2003: Jennifer H Lee; John Kisiday; Alan J Grodzinsky
Tissue-engineered versus native cartilage: linkage between cellular mechano-transduction and biomechanical properties.
Novartis Foundation symposium 2003;249():52-64; discussion 64-9, 170-4, 239-41.
2002: Thomas M Quinn; Claude Studer; Alan J Grodzinsky; Jean-Jacques Meister
Preservation and analysis of nonequilibrium solute concentration distributions within mechanically compressed cartilage explants.
Journal of biochemical and biophysical methods 2002;52(2):83-95.
2002: John Kisiday; Moonsoo Jin; Bodo Kurz; H Hung; Carlos E Semino; Shuguang Zhang; Alan J Grodzinsky
Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):9996-10001.
2002: Thomas M Quinn; Pirmin Schmid; Ernst B Hunziker; Alan J Grodzinsky
Proteoglycan deposition around chondrocytes in agarose culture: construction of a physical and biological interface for mechanotransduction in cartilage.
Biorheology 2002;39(1-2):27-37.
2002: Alex Kerin; Parth Patwari; Klaus E Kuettner; A Cole; Alan J Grodzinsky
Molecular basis of osteoarthritis: biomechanical aspects.
Cellular and molecular life sciences : CMLS 2002;59(1):27-35.
2001: Bodo Kurz; M Jin; Parth Patwari; D M Cheng; Michael W Lark; Alan J Grodzinsky
Biosynthetic response and mechanical properties of articular cartilage after injurious compression.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2001;19(6):1140-6.
2001: Moonsoo Jin; Eliot H Frank; Thomas M Quinn; Ernst B Hunziker; Alan J Grodzinsky
Tissue shear deformation stimulates proteoglycan and protein biosynthesis in bovine cartilage explants.
Archives of biochemistry and biophysics 2001;395(1):41-8.
2001: Thomas M Quinn; P Dierickx; Alan J Grodzinsky
Glycosaminoglycan network geometry may contribute to anisotropic hydraulic permeability in cartilage under compression.
Journal of biomechanics 2001;34(11):1483-90.
2001: Parth Patwari; Jakob Fay; Michael N Cook; AM Badger; Alex Kerin; Michael W Lark; Alan J Grodzinsky
In vitro models for investigation of the effects of acute mechanical injury on cartilage.
Clinical orthopaedics and related research 2001;(391 Suppl):S61-71.
2001: Linden T Hu; MA Eskildsen; C Masgala; Allen C Steere; Elizabeth C Arner; Michael A Pratta; Alan J Grodzinsky; AM Loening; George Perides
Host metalloproteinases in Lyme arthritis.
Arthritis and rheumatism 2001;44(6):1401-10.
2001: Linda G Griffith; Alan J Grodzinsky
Advances in biomedical engineering.
JAMA : the journal of the American Medical Association 2001;285(5):556-61.
2001: Lawrence J Bonassar; Alan J Grodzinsky; E H Frank; S G Davila; N R Bhaktav; Stephen B Trippel
The effect of dynamic compression on the response of articular cartilage to insulin-like growth factor-I.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2001;19(1):11-7.
2000: PM Ragan; V I Chin; Han-Hwa Hung; K Masuda; Eugene Thonar; Elizabeth C Arner; Alan J Grodzinsky; John D Sandy
Chondrocyte extracellular matrix synthesis and turnover are influenced by static compression in a new alginate disk culture system.
Archives of biochemistry and biophysics 2000;383(2):256-64.
2000: Eliot H Frank; Moonsoo Jin; AM Loening; ME Levenston; Alan J Grodzinsky
A versatile shear and compression apparatus for mechanical stimulation of tissue culture explants.
Journal of biomechanics 2000;33(11):1523-7.
2000: AM Loening; Ian E James; ME Levenston; AM Badger; Eliot H Frank; Bodo Kurz; Mark E Nuttall; Han-Hwa Hung; Simon M Blake; Alan J Grodzinsky; Michael W Lark
Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis.
Archives of biochemistry and biophysics 2000;381(2):205-12.
2000: CR Lee; Alan J Grodzinsky; HP Hsu; Scott David Martin; Myron Spector
Effects of harvest and selected cartilage repair procedures on the physical and biochemical properties of articular cartilage in the canine knee.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2000;18(5):790-9.
2000: S Treppo; Holger E Koepp; E C Quan; Ada A Cole; Klaus E Kuettner; Alan J Grodzinsky
Comparison of biomechanical and biochemical properties of cartilage from human knee and ankle pairs.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2000;18(5):739-48.
2000: Lawrence J Bonassar; Alan J Grodzinsky; A Srinivasan; S G Davila; Stephen B Trippel
Mechanical and physicochemical regulation of the action of insulin-like growth factor-I on articular cartilage.
Archives of biochemistry and biophysics 2000;379(1):57-63.
2000: Paolo A Netti; David A Berk; Melody Swartz; Alan J Grodzinsky; Rakesh K Jain
Role of extracellular matrix assembly in interstitial transport in solid tumors.
Cancer research 2000;60(9):2497-503.
2000: N R Bhakta; A Minerva Garcia; Eliot H Frank; Alan J Grodzinsky; Teresa I Morales
The insulin-like growth factors (IGFs) I and II bind to articular cartilage via the IGF-binding proteins.
The Journal of biological chemistry 2000;275(8):5860-6.
2000: Parth Patwari; Bodo Kurz; John D Sandy; Alan J Grodzinsky
Mannosamine inhibits aggrecanase-mediated changes in the physical properties and biochemical composition of articular cartilage.
Archives of biochemistry and biophysics 2000;374(1):79-85.
2000: Alan J Grodzinsky; ME Levenston; Moonsoo Jin; Eliot H Frank
Cartilage tissue remodeling in response to mechanical forces.
Annual review of biomedical engineering 2000;2():691-713.
2000: Ivan Martin; B Obradovic; S Treppo; Alan J Grodzinsky; Robert Langer; Lisa E Freed; Gordana Vunjak-Novakovic
Modulation of the mechanical properties of tissue engineered cartilage.
Biorheology 2000;37(1-2):141-7.
1999: Melody Swartz; A Kaipainen; Paolo A Netti; C Brekken; Yves Boucher; Alan J Grodzinsky; Rakesh K Jain
Mechanics of interstitial-lymphatic fluid transport: theoretical foundation and experimental validation.
Journal of biomechanics 1999;32(12):1297-307.
1999: PM Ragan; AM Badger; M Cook; V I Chin; Maxine Gowen; Alan J Grodzinsky; Michael W Lark
Down-regulation of chondrocyte aggrecan and type-II collagen gene expression correlates with increases in static compression magnitude and duration.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1999;17(6):836-42.
1999: Thomas M Quinn; A A Maung; Alan J Grodzinsky; Ernst B Hunziker; John D Sandy
Physical and biological regulation of proteoglycan turnover around chondrocytes in cartilage explants. Implications for tissue degradation and repair.
Annals of the New York Academy of Sciences 1999;878():420-41.
1999: Gordana Vunjak-Novakovic; Ivan Martin; B Obradovic; S Treppo; Alan J Grodzinsky; Robert Langer; Lisa E Freed
Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue-engineered cartilage.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1999;17(1):130-8.
1998: A Minerva Garcia; Michael W Lark; Stephen B Trippel; Alan J Grodzinsky
Transport of tissue inhibitor of metalloproteinases-1 through cartilage: contributions of fluid flow and electrical migration.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1998;16(6):734-42.
1998: Thomas M Quinn; Alan J Grodzinsky; Ernst B Hunziker; John D Sandy
Effects of injurious compression on matrix turnover around individual cells in calf articular cartilage explants.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1998;16(4):490-9.
1998: Thomas M Quinn; Alan J Grodzinsky; M D Buschmann; Y J Kim; Ernst B Hunziker
Mechanical compression alters proteoglycan deposition and matrix deformation around individual cells in cartilage explants.
Journal of cell science 1998;111 ( Pt 5)():573-83.
1997: Lawrence J Bonassar; John D Sandy; Michael W Lark; Anna Plaas; Eliot H Frank; Alan J Grodzinsky
Inhibition of cartilage degradation and changes in physical properties induced by IL-1beta and retinoic acid using matrix metalloproteinase inhibitors.
Archives of biochemistry and biophysics 1997;344(2):404-12.
1996: L J Bonassar; J L Stinn; C G Paguio; E H Frank; V L Moore; Michael W Lark; John D Sandy; A P Hollander; A R Poole; Alan J Grodzinsky
Activation and inhibition of endogenous matrix metalloproteinases in articular cartilage: effects on composition and biophysical properties.
Archives of biochemistry and biophysics 1996;333(2):359-67.
1996: A M Garcia; E H Frank; P E Grimshaw; Alan J Grodzinsky
Contributions of fluid convection and electrical migration to transport in cartilage: relevance to loading.
Archives of biochemistry and biophysics 1996;333(2):317-25.
1996: Y J Kim; Alan J Grodzinsky; Anna Plaas
Compression of cartilage results in differential effects on biosynthetic pathways for aggrecan, link protein, and hyaluronan.
Archives of biochemistry and biophysics 1996;328(2):331-40.
1996: Michael D Buschmann; Ernst B Hunziker; Y J Kim; Alan J Grodzinsky
Altered aggrecan synthesis correlates with cell and nucleus structure in statically compressed cartilage.
Journal of cell science 1996;109 ( Pt 2)():499-508.
1996: Robert Sah; S B Trippel; Alan J Grodzinsky
Differential effects of serum, insulin-like growth factor-I, and fibroblast growth factor-2 on the maintenance of cartilage physical properties during long-term culture.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1996;14(1):44-52.
1996: G C Cheng; Peter Libby; Alan J Grodzinsky; Richard T Lee
Induction of DNA synthesis by a single transient mechanical stimulus of human vascular smooth muscle cells. Role of fibroblast growth factor-2.
Circulation 1996;93(1):99-105.
1996: E Lee; D E Vaughan; S H Parikh; Alan J Grodzinsky; P Libby; M W Lark; R T Lee
Regulation of matrix metalloproteinases and plasminogen activator inhibitor-1 synthesis by plasminogen in cultured human vascular smooth muscle cells.
Circulation research 1996;78(1):44-9.
1995: E Lee; Alan J Grodzinsky; P Libby; S K Clinton; M W Lark; R T Lee
Human vascular smooth muscle cell-monocyte interactions and metalloproteinase secretion in culture.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(12):2284-9.
1995: L J Bonassar; K A Jeffries; C G Paguio; Alan J Grodzinsky
Cartilage degradation and associated changes in biochemical and electromechanical properties.
Acta orthopaedica Scandinavica. Supplementum 1995;266():38-44.
1995: Y J Kim; L J Bonassar; Alan J Grodzinsky
The role of cartilage streaming potential, fluid flow and pressure in the stimulation of chondrocyte biosynthesis during dynamic compression.
Journal of biomechanics 1995;28(9):1055-66.
1995: Frédéric Mallein-Gerin; F Ruggiero; Thomas M Quinn; F Bard; Alan J Grodzinsky; B R Olsen; M van der Rest
Analysis of collagen synthesis and assembly in culture by immortalized mouse chondrocytes in the presence or absence of alpha 1(IX) collagen chains.
Experimental cell research 1995;219(1):257-65.
1995: Michael D Buschmann; Alan J Grodzinsky
A molecular model of proteoglycan-associated electrostatic forces in cartilage mechanics.
Journal of biomechanical engineering 1995;117(2):179-92.
1995: Michael D Buschmann; Y A Gluzband; Alan J Grodzinsky; Ernst B Hunziker
Mechanical compression modulates matrix biosynthesis in chondrocyte/agarose culture.
Journal of cell science 1995;108 ( Pt 4)():1497-508.
1995: L J Bonassar; E H Frank; J C Murray; C G Paguio; V L Moore; Michael W Lark; John D Sandy; J J Wu; D R Eyre; Alan J Grodzinsky
Changes in cartilage composition and physical properties due to stromelysin degradation.
Arthritis and rheumatism 1995;38(2):173-83.
1994: S I Berkenblit; E H Frank; E P Salant; Alan J Grodzinsky
Nondestructive detection of cartilage degeneration using electromechanical surface spectroscopy.
Journal of biomechanical engineering 1994;116(4):384-92.
1994: L J Bonassar; C G Paguio; E H Frank; K A Jeffries; V L Moore; Michael W Lark; C G Caldwell; William K Hagmann; Alan J Grodzinsky
Effects of matrix metalloproteinases on cartilage biophysical properties in vitro and in vivo.
Annals of the New York Academy of Sciences 1994;732():439-43.
1994: Y J Kim; Robert Sah; Alan J Grodzinsky; Anna Plaas; John D Sandy
Mechanical regulation of cartilage biosynthetic behavior: physical stimuli.
Archives of biochemistry and biophysics 1994;311(1):1-12.
1994: L A MacGinitie; Y A Gluzband; Alan J Grodzinsky
Electric field stimulation can increase protein synthesis in articular cartilage explants.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1994;12(2):151-60.
1994: H M Loree; Alan J Grodzinsky; S Y Park; L J Gibson; Richard T Lee
Static circumferential tangential modulus of human atherosclerotic tissue.
Journal of biomechanics 1994;27(2):195-204.
1994: Robert Sah; Albert C Chen; Alan J Grodzinsky; S B Trippel
Differential effects of bFGF and IGF-I on matrix metabolism in calf and adult bovine cartilage explants.
Archives of biochemistry and biophysics 1994;308(1):137-47.
1992: Michael D Buschmann; Y A Gluzband; Alan J Grodzinsky; J H Kimura; Ernst B Hunziker
Chondrocytes in agarose culture synthesize a mechanically functional extracellular matrix.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1992;10(6):745-58.
1992: Richard T Lee; S G Richardson; H M Loree; Alan J Grodzinsky; S A Gharib; Frederick J Schoen; N Pandian
Prediction of mechanical properties of human atherosclerotic tissue by high-frequency intravascular ultrasound imaging. An in vitro study.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1992;12(1):1-5.
1991: Richard T Lee; Alan J Grodzinsky; E H Frank; Roger Kamm; Frederick J Schoen
Structure-dependent dynamic mechanical behavior of fibrous caps from human atherosclerotic plaques.
Circulation 1991;83(5):1764-70.
1991: Robert Sah; J Y Doong; Alan J Grodzinsky; Anna Plaas; John D Sandy
Effects of compression on the loss of newly synthesized proteoglycans and proteins from cartilage explants.
Archives of biochemistry and biophysics 1991;286(1):20-9.
1990: Robert Sah; Alan J Grodzinsky; Anna Plaas; John D Sandy
Effects of tissue compression on the hyaluronate-binding properties of newly synthesized proteoglycans in cartilage explants.
The Biochemical journal 1990;267(3):803-8.
1989: Martha Gray; A M Pizzanelli; Raphael Lee; Alan J Grodzinsky; D A Swann
Kinetics of the chondrocyte biosynthetic response to compressive load and release.
Biochimica et biophysica acta 1989;991(3):415-25.
1989: Robert Sah; Y J Kim; J Y Doong; Alan J Grodzinsky; Anna Plaas; John D Sandy
Biosynthetic response of cartilage explants to dynamic compression.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1989;7(5):619-36.
1988: Martha Gray; A M Pizzanelli; Alan J Grodzinsky; Raphael Lee
Mechanical and physiochemical determinants of the chondrocyte biosynthetic response.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1988;6(6):777-92.
1987: E H Frank; Alan J Grodzinsky; T J Koob; D R Eyre
Streaming potentials: a sensitive index of enzymatic degradation in articular cartilage.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1987;5(4):497-508.
1987: E H Frank; Alan J Grodzinsky
Cartilage electromechanics--II. A continuum model of cartilage electrokinetics and correlation with experiments.
Journal of biomechanics 1987;20(6):629-39.
1987: E H Frank; Alan J Grodzinsky
Cartilage electromechanics--I. Electrokinetic transduction and the effects of electrolyte pH and ionic strength.
Journal of biomechanics 1987;20(6):615-27.
1983: D H Hoch; Alan J Grodzinsky; T J Koob; M L Albert; D R Eyre
Early changes in material properties of rabbit articular cartilage after meniscectomy.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1983;1(1):4-12.
1981: Raphael Lee; E H Frank; Alan J Grodzinsky; D K Roylance
Oscillatory compressional behavior of articular cartilage and its associated electromechanical properties.
Journal of biomechanical engineering 1981;103(4):280-92.