FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

John Groffen

Research Profile

Living Beings

Chemicals & Drugs

Genes & Molecular Sequences

Concepts & Ideas

Molecular Sequence Data

Disorders

Phenomena

Phosphorylation

Anatomy

Chromosomes, Human, Pair 22

Co-author Network

Publications

TOP 3
Reshmi Parameswaran; Mark von Itzstein; Robert K Yu; Hisham Abdel-Azim; Anna Arutyunyan; Nora Heisterkamp; Christian Hurtz; Kam Lau; Min Lim; Markus Müschen; John Groffen
O-acetylated N-acetylneuraminic acid as a novel target for therapy in human pre-B acute lymphoblastic leukemia.
R Parameswaran; M G Rosenblum; M Yu; John Groffen; M Lim; M-A Lyu; Nora Heisterkamp
Treatment of acute lymphoblastic leukemia with an rGel/BLyS fusion toxin.
Min Yu; Min Lim; Anna Arutyunyan; Dapeng Gong; John Groffen; Nora Heisterkamp
Lack of bcr and abr promotes hypoxia-induced pulmonary hypertension in mice.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of John Groffen (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Reshmi Parameswaran; Mark von Itzstein; Robert K Yu; Hisham Abdel-Azim; Anna Arutyunyan; Nora Heisterkamp; Christian Hurtz; Kam Lau; Min Lim; Markus Müschen; John Groffen
O-acetylated N-acetylneuraminic acid as a novel target for therapy in human pre-B acute lymphoblastic leukemia.
The Journal of experimental medicine 2013;210(4):805-19.
2012: R Parameswaran; M G Rosenblum; M Yu; John Groffen; M Lim; M-A Lyu; Nora Heisterkamp
Treatment of acute lymphoblastic leukemia with an rGel/BLyS fusion toxin.
Leukemia 2012;26(8):1786-96.
2012: Min Yu; Min Lim; Anna Arutyunyan; Dapeng Gong; John Groffen; Nora Heisterkamp
Lack of bcr and abr promotes hypoxia-induced pulmonary hypertension in mice.
PloS one 2012;7(11):e49756.
2012: Anna Arutyunyan; Fei Fei; Niklas Feldhahn; John Groffen; Paula Groffen; Min Lim; Sonia Stoddart; Sun-ju Yi; Nora Heisterkamp
Expression of cassini, a murine gamma-satellite sequence conserved in evolution, is regulated in normal and malignant hematopoietic cells.
BMC genomics 2012;13():418.
2012: Fei Fei; John Groffen; Min Lim; Jürgen Moll; Sabine Schmidhuber; Nora Heisterkamp
Treatment of human pre-B acute lymphoblastic leukemia with the Aurora kinase inhibitor PHA-739358 (Danusertib).
Molecular cancer 2012;11():42.
2012: Dapeng Gong; John Groffen; Wei Shi; Sun-ju Yi; Hui Chen; Nora Heisterkamp
TGFβ signaling plays a critical role in promoting alternative macrophage activation.
BMC immunology 2012;13():31.
2011: R Parameswaran; M Yu; John Groffen; M Lim; Nora Heisterkamp
Combination of drug therapy in acute lymphoblastic leukemia with a CXCR4 antagonist.
Leukemia 2011;25(8):1314-23.
2011: Sun-Ju Yi; John Groffen; Nora Heisterkamp
Bcr is a substrate for Transglutaminase 2 cross-linking activity.
BMC biochemistry 2011;12():8.
2010: Daeyoung Oh; Seungnam Han; Jinsoo Seo; Jae-Ran Lee; Jeonghoon Choi; John Groffen; Karam Kim; Yi Sul Cho; Han-Saem Choi; Hyewon Shin; Jooyeon Woo; Hyejung Won; Soon Kwon Park; Soo-Young Kim; Jihoon Jo; Daniel J Whitcomb; Kwangwook Cho; Hyun Kim; Yong Chul Bae; Nora Heisterkamp; Se-Young Choi; Eunjoon Kim
Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(42):14134-44.
2010: Jason P Yun; James W Behan; Nora Heisterkamp; Anna Butturini; Lars Klemm; Lingyun Ji; John Groffen; Markus Müschen; Steven D Mittelman
Diet-induced obesity accelerates acute lymphoblastic leukemia progression in two murine models.
Cancer prevention research (Philadelphia, Pa.) 2010;3(10):1259-64.
2010: Aimin Li; Yiming Xing; Belinda Chan; Nora Heisterkamp; John Groffen; Zea Borok; Parviz Minoo; Changgong Li
Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair.
Developmental dynamics : an official publication of the American Association of Anatomists 2010;239(8):2288-97.
2010: Reshmi Parameswaran; Markus Müschen; Yong Kim; John Groffen; Nora Heisterkamp
A functional receptor for B-cell-activating factor is expressed on human acute lymphoblastic leukemias.
Cancer research 2010;70(11):4346-56.
2010: Fei Fei; Sonia Stoddart; John Groffen; Nora Heisterkamp
Activity of the Aurora kinase inhibitor VX-680 against Bcr/Abl-positive acute lymphoblastic leukemias.
Molecular cancer therapeutics 2010;9(5):1318-27.
2010: F Fei; S Stoddart; Markus Müschen; Y-m Kim; John Groffen; Nora Heisterkamp
Development of resistance to dasatinib in Bcr/Abl-positive acute lymphoblastic leukemia.
Leukemia 2010;24(4):813-20.
2010: Fei Fei; Soo-Mi Kweon; Leena Haataja; Paulo de Sepulveda; John Groffen; Nora Heisterkamp
The Fer tyrosine kinase regulates interactions of Rho GDP-Dissociation Inhibitor α with the small GTPase Rac.
BMC biochemistry 2010;11():48.
2009: Sun-Ju Yi; John Groffen; Nora Heisterkamp
Transglutaminase 2 regulates the GTPase-activating activity of Bcr.
The Journal of biological chemistry 2009;284(51):35645-51.
2009: Jess M Cunnick; Sabine Schmidhuber; Gang Chen; Min Yu; Sun-Ju Yi; Young Jin Cho; Vesa Kaartinen; Parviz Minoo; David Warburton; John Groffen; Nora Heisterkamp
Bcr and Abr cooperate in negatively regulating acute inflammatory responses.
Molecular and cellular biology 2009;29(21):5742-50.
2009: Lars Klemm; Duy Cihangir; Ilaria Iacobucci; Stefan Kuchen; Gregor von Levetzow; Niklas Feldhahn; Nadine Henke; Zhiyu Li; Thomas K Hoffmann; Yong Kim; Wolf-Karsten Hofmann; Hassan Jumaa; John Groffen; Nora Heisterkamp; Giovanni Martinelli; Michael R Lieber; Rafael Casellas; Markus Müschen
The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia.
Cancer cell 2009;16(3):232-45.
2009: Daniel Trageser; Ilaria Iacobucci; Rahul Nahar; Duy Cihangir; Gregor von Levetzow; Lars Klemm; Eugene Park; Wolfgang Schuh; Tanja Gruber; Sebastian Herzog; Yong Kim; Wolf-Karsten Hofmann; Aihong Li; Clelia Tiziana Storlazzi; Hans-Martin Jäck; John Groffen; Giovanni Martinelli; Nora Heisterkamp; Hassan Jumaa; Markus Müschen
Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function.
The Journal of experimental medicine 2009;206(8):1739-53.
2008: Sun-Ju Yi; Hyung-Taek Lee; John Groffen; Nora Heisterkamp
Bcr/Abl P190 interaction with Spa-1, a GTPase activating protein for the small GTPase Rap1.
International journal of molecular medicine 2008;22(4):453-8.
2008: Nora Heisterkamp; John Groffen; David Warburton; Tam P Sneddon
The human gamma-glutamyltransferase gene family.
Human genetics 2008;123(4):321-32.
2008: Soo-Mi Kweon; Young Jin Cho; Parviz Minoo; John Groffen; Nora Heisterkamp
Activity of the Bcr GTPase-activating domain is regulated through direct protein/protein interaction with the Rho guanine nucleotide dissociation inhibitor.
The Journal of biological chemistry 2008;283(6):3023-30.
2008: Parviz Minoo; Lingyan Hu; Nian-Ling Zhu; Zea Borok; Saverio Bellusci; John Groffen; Dimitris Kardassis; Changgong Li
SMAD3 prevents binding of NKX2.1 and FOXA1 to the SpB promoter through its MH1 and MH2 domains.
Nucleic acids research 2008;36(1):179-88.
2008: Kjetil Ask; Philippe Bonniaud; Katja Maass; Oliver Eickelberg; Peter J Margetts; David Warburton; John Groffen; Jack Gauldie; Martin Kolb
Progressive pulmonary fibrosis is mediated by TGF-beta isoform 1 but not TGF-beta3.
The international journal of biochemistry & cell biology 2008;40(3):484-95.
2007: Wei Ding; Wei Shi; Saverio Bellusci; John Groffen; Nora Heisterkamp; Parviz Minoo; David Warburton
Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF-beta1 signaling and EGF as well as FGF receptor tyrosine kinase-ERK pathways in mesenchymal cells.
Journal of cellular physiology 2007;212(3):796-806.
2007: Bin Zhang; John Groffen; Nora Heisterkamp
Increased resistance to a farnesyltransferase inhibitor by N-cadherin expression in Bcr/Abl-P190 lymphoblastic leukemia cells.
Leukemia 2007;21(6):1189-97.
2007: Young Jin Cho; Jess M Cunnick; Sun-Ju Yi; Vesa Kaartinen; John Groffen; Nora Heisterkamp
Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages.
Molecular and cellular biology 2007;27(3):899-911.
2007: Pavinder Kaur; Niklas Feldhahn; Bin Zhang; Daniel Trageser; Markus Müschen; Veerle Pertz; John Groffen; Nora Heisterkamp
Nilotinib treatment in mouse models of P190 Bcr/Abl lymphoblastic leukemia.
Molecular cancer 2007;6():67.
2007: S Mishra; V Pertz; B Zhang; P Kaur; H Shimada; John Groffen; Z Kazimierczuk; L A Pinna; Nora Heisterkamp
Treatment of P190 Bcr/Abl lymphoblastic leukemia cells with inhibitors of the serine/threonine kinase CK2.
Leukemia 2007;21(1):178-80.
2006: Suparna Mishra; Bin Zhang; Jess M Cunnick; Nora Heisterkamp; John Groffen
Resistance to imatinib of bcr/abl p190 lymphoblastic leukemia cells.
Cancer research 2006;66(10):5387-93.
2006: Jess M Cunnick; Pavinder Kaur; Youngjin Cho; John Groffen; Nora Heisterkamp
Use of bone marrow-derived macrophages to model murine innate immune responses.
Journal of immunological methods 2006;311(1-2):96-105.
2005: Bin Zhang; John Groffen; Nora Heisterkamp
Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a.
Blood 2005;106(4):1355-61.
2005: Young Jin Cho; Bianca Hemmeryckx; John Groffen; Nora Heisterkamp
Interaction of Bcr/Abl with C3G, an exchange factor for the small GTPase Rap1, through the adapter protein Crkl.
Biochemical and biophysical research communications 2005;333(4):1276-83.
2005: Young Jin Cho; Bin Zhang; Vesa Kaartinen; Leena Haataja; Ivan de Curtis; John Groffen; Nora Heisterkamp
Generation of rac3 null mutant mice: role of Rac3 in Bcr/Abl-caused lymphoblastic leukemia.
Molecular and cellular biology 2005;25(13):5777-85.
2004: Christina Curtis; Bianca Hemmeryckx; Leena Haataja; Dinithi Senadheera; John Groffen; Nora Heisterkamp
Scambio, a novel guanine nucleotide exchange factor for Rho.
Molecular cancer 2004;3():10.
2004: Suparna Mishra; Bin Zhang; John Groffen; Nora Heisterkamp
A farnesyltransferase inhibitor increases survival of mice with very advanced stage acute lymphoblastic leukemia/lymphoma caused by P190 Bcr/Abl.
Leukemia 2004;18(1):23-8.
2003: Suparna Mishra; Anja Reichert; Jess M Cunnick; Dinithi Senadheera; Bianca Hemmeryckx; Nora Heisterkamp; John Groffen
Protein kinase CKIIalpha interacts with the Bcr moiety of Bcr/Abl and mediates proliferation of Bcr/Abl-expressing cells.
Oncogene 2003;22(51):8255-62.
2003: Karen Leung; Andre Nagy; Ignacio Gonzalez-Gomez; John Groffen; Nora Heisterkamp; Vesa Kaartinen
Targeted expression of activated Rac3 in mammary epithelium leads to defective postlactational involution and benign mammary gland lesions.
Cells, tissues, organs 2003;175(2):72-83.
2002: Nora Heisterkamp; John Groffen
Philadelphia-positive leukemia: a personal perspective.
Oncogene 2002;21(56):8536-40.
2002: Vesa Kaartinen; Leena Haataja; Andre Nagy; Nora Heisterkamp; John Groffen
TGFbeta3-induced activation of RhoA/Rho-kinase pathway is necessary but not sufficient for epithelio-mesenchymal transdifferentiation: implications for palatogenesis.
International journal of molecular medicine 2002;9(6):563-70.
2002: Bianca Hemmeryckx; Anja Reichert; Meguru Watanabe; Vesa Kaartinen; Ron de Jong; Paul K Pattengale; John Groffen; Nora Heisterkamp
BCR/ABL P190 transgenic mice develop leukemia in the absence of Crkl.
Oncogene 2002;21(20):3225-31.
2002: Stijn P De Langhe; Leena Haataja; Dinithi Senadheera; John Groffen; Nora Heisterkamp
Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain.
International journal of molecular medicine 2002;9(5):451-9.
2002: Vesa Kaartinen; Andre Nagy; Ignacio Gonzalez-Gomez; John Groffen; Nora Heisterkamp
Vestibular dysgenesis in mice lacking Abr and Bcr Cdc42/RacGAPs.
Developmental dynamics : an official publication of the American Association of Anatomists 2002;223(4):517-25.
2002: Leena Haataja; Vesa Kaartinen; John Groffen; Nora Heisterkamp
The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading.
The Journal of biological chemistry 2002;277(10):8321-8.
2001: Vesa Kaartinen; Ignacio Gonzalez-Gomez; JW Voncken; Leena Haataja; E Faure; Andre Nagy; John Groffen; Nora Heisterkamp
Abnormal function of astroglia lacking Abr and Bcr RacGAPs.
Development (Cambridge, England) 2001;128(21):4217-27.
2001: Dinithi Senadheera; Leena Haataja; John Groffen; Nora Heisterkamp
The small GTPase Rac interacts with ubiquitination complex proteins Cullin-1 and CDC23.
International journal of molecular medicine 2001;8(2):127-33.
2001: Laurence Blavier; Alisa Lazaryev; John Groffen; Nora Heisterkamp; Yves A DeClerck; Vesa Kaartinen
TGF-beta3-induced palatogenesis requires matrix metalloproteinases.
Molecular biology of the cell 2001;12(5):1457-66.
2001: Nora Heisterkamp; JW Voncken; Dinithi Senadheera; Bianca Hemmeryckx; Ignacio Gonzalez-Gomez; Anja Reichert; Paul K Pattengale; John Groffen
The Bcr N-terminal oligomerization domain contributes to the full oncogenicity of P190 Bcr/Abl in transgenic mice.
International journal of molecular medicine 2001;7(4):351-7.
2001: Anja Reichert; Nora Heisterkamp; G Q Daley; John Groffen
Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in P190 transgenic mice with the farnesyl transferase inhibitor SCH66336.
Blood 2001;97(5):1399-403.
2001: Bianca Hemmeryckx; A van Wijk; Anja Reichert; Vesa Kaartinen; Ron de Jong; Paul K Pattengale; Ignacio Gonzalez-Gomez; John Groffen; Nora Heisterkamp
Crkl enhances leukemogenesis in BCR/ABL P190 transgenic mice.
Cancer research 2001;61(4):1398-405.
2000: Nora Heisterkamp; JW Voncken; Dinithi Senadheera; Ignacio Gonzalez-Gomez; Anja Reichert; Leena Haataja; A Reinikainen; Paul K Pattengale; John Groffen
Reduced oncogenicity of p190 Bcr/Abl F-actin-binding domain mutants.
Blood 2000;96(6):2226-32.
2000: H F Salloukh; I Vowles; Nora Heisterkamp; John Groffen; Pierre Laneuville
Early events in leukemogenesis in P190Bcr-abl transgenic mice.
Oncogene 2000;19(38):4362-74.
2000: TT Nguyen; Ann Mohrbacher; Yvonne C Tsai; John Groffen; Nora Heisterkamp; Peter W Nichols; Mimi C Yu; M Lübbert; Peter A Jones
Quantitative measure of c-abl and p15 methylation in chronic myelogenous leukemia: biological implications.
Blood 2000;95(9):2990-2.
2000: E Faure; Nora Heisterkamp; John Groffen; Vesa Kaartinen
Differential expression of TGF-beta isoforms during postlactational mammary gland involution.
Cell and tissue research 2000;300(1):89-95.
2000: Ulla Dunder; Vesa Kaartinen; P Valtonen; E Väänänen; Veli-Matti Kosma; Nora Heisterkamp; John Groffen; Ilkka Mononen
Enzyme replacement therapy in a mouse model of aspartylglycosaminuria.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(2):361-7.
2000: Christine Morris; Leena Haataja; M McDonald; S Gough; D Markie; John Groffen; Nora Heisterkamp
The small GTPase RAC3 gene is located within chromosome band 17q25.3 outside and telomeric of a region commonly deleted in breast and ovarian tumours.
Cytogenetics and cell genetics 2000;89(1-2):18-23.
1999: Wei Shi; Nora Heisterkamp; John Groffen; Jingsong Zhao; David Warburton; Vesa Kaartinen
TGF-beta3-null mutation does not abrogate fetal lung maturation in vivo by glucocorticoids.
The American journal of physiology 1999;277(6 Pt 1):L1205-13.
1999: John Groffen; Ron de Jong; Leena Haataja; Vesa Kaartinen; Nora Heisterkamp
Phosphorylation substrates and altered signalling in leukemias caused by BCR/ABL.
Leukemia 1999;13 Suppl 1():S81-2.
1998: Ron de Jong; A van Wijk; Nora Heisterkamp; John Groffen
C3G is tyrosine-phosphorylated after integrin-mediated cell adhesion in normal but not in Bcr/Abl expressing cells.
Oncogene 1998;17(21):2805-10.
1998: W T Kyono; Ron de Jong; RK Park; Yi Liu; Nora Heisterkamp; John Groffen; Donald L Durden
Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI).
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5555-63.
1998: JW Voncken; T Z Baram; Ignacio Gonzales-Gomez; H Van Schaick; J C Shih; K Chen; John Groffen; Nora Heisterkamp
Abnormal stress response and increased fighting behavior in mice lacking the bcr gene product.
International journal of molecular medicine 1998;2(5):577-83.
1998: Ignacio Gonzalez-Gomez; Ilkka Mononen; Nora Heisterkamp; John Groffen; Vesa Kaartinen
Progressive neurodegeneration in aspartylglycosaminuria mice.
The American journal of pathology 1998;153(4):1293-300.
1998: R Rosato; Jacqueline M Veltmaat; John Groffen; Nora Heisterkamp
Involvement of the tyrosine kinase fer in cell adhesion.
Molecular and cellular biology 1998;18(10):5762-70.
1998: Alan L Shanske; H Grunwald; P Cook; Nora Heisterkamp; John Groffen
Philadelphia-negative chronic myelogenous leukemia in a patient with a unique complex translocation: 46,XY,t(9;12;15)(q34;12;q21).
Leukemia research 1998;22(7):645-8.
1998: Vesa Kaartinen; Ilkka Mononen; Ignacio Gonzalez-Gomez; Tiina Noronkoski; Nora Heisterkamp; John Groffen
Phenotypic characterization of mice with targeted disruption of glycosylasparaginase gene: a mouse model for aspartylglycosaminuria.
Journal of inherited metabolic disease 1998;21(3):207-9.
1998: JW Voncken; Vesa Kaartinen; John Groffen; Nora Heisterkamp
Bcr/Abl associated leukemogenesis in bcr null mutant mice.
Oncogene 1998;16(15):2029-32.
1998: Leena Haataja; John Groffen; Nora Heisterkamp
Identification of a novel Rac3-interacting protein C1D.
International journal of molecular medicine 1998;1(4):665-70.
1997: Ron de Jong; A van Wijk; Leena Haataja; Nora Heisterkamp; John Groffen
BCR/ABL-induced leukemogenesis causes phosphorylation of Hef1 and its association with Crkl.
The Journal of biological chemistry 1997;272(51):32649-55.
1997: Leena Haataja; John Groffen; Nora Heisterkamp
Characterization of RAC3, a novel member of the Rho family.
The Journal of biological chemistry 1997;272(33):20384-8.
1997: Vesa Kaartinen; Xiao-Mei Cui; Nora Heisterkamp; John Groffen; Charles F Shuler
Transforming growth factor-beta3 regulates transdifferentiation of medial edge epithelium during palatal fusion and associated degradation of the basement membrane.
Developmental dynamics : an official publication of the American Association of Anatomists 1997;209(3):255-60.
1997: John Groffen; Nora Heisterkamp
The chimeric BCR-ABL gene.
Baillière's clinical haematology 1997;10(2):187-201.
1997: Yang Chai; Y Sasano; Pablo Bringas; M Mayo; Vesa Kaartinen; Nora Heisterkamp; John Groffen; Harold Charles Slavkin; Charles F Shuler
Characterization of the fate of midline epithelial cells during the fusion of mandibular prominences in vivo.
Developmental dynamics : an official publication of the American Association of Anatomists 1997;208(4):526-35.
1997: Ron de Jong; J ten Hoeve; Nora Heisterkamp; John Groffen
Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site.
Oncogene 1997;14(5):507-13.
1997: Leena Haataja; C Raffel; David Ledbetter; A Tanigami; D Petersen; Nora Heisterkamp; John Groffen
Deletion within the D17S34 locus in a primitive neuroectodermal tumor.
Cancer research 1997;57(1):32-4.
1996: Vesa Kaartinen; Ilkka Mononen; JW Voncken; Tiina Noronkoski; Ignacio Gonzalez-Gomez; Nora Heisterkamp; John Groffen
A mouse model for the human lysosomal disease aspartylglycosaminuria.
Nature medicine 1996;2(12):1375-8.
1995: JW Voncken; Vesa Kaartinen; Paul K Pattengale; W T Germeraad; John Groffen; Nora Heisterkamp
BCR/ABL P210 and P190 cause distinct leukemia in transgenic mice.
Blood 1995;86(12):4603-11.
1995: Vesa Kaartinen; JW Voncken; Charles F Shuler; D Warburton; D Bu; Nora Heisterkamp; John Groffen
Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction.
Nature genetics 1995;11(4):415-21.
1995: Ron de Jong; Leena Haataja; JW Voncken; Nora Heisterkamp; John Groffen
Tyrosine phosphorylation of murine Crkl.
Oncogene 1995;11(8):1469-74.
1995: Nora Heisterkamp; M P Mulder; An Langeveld; J ten Hoeve; Z Wang; B A Roe; John Groffen
Localization of the human mitochondrial citrate transporter protein gene to chromosome 22Q11 in the DiGeorge syndrome critical region.
Genomics 1995;29(2):451-6.
1995: Ron de Jong; J ten Hoeve; Nora Heisterkamp; John Groffen
Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive leukemia.
The Journal of biological chemistry 1995;270(37):21468-71.
1995: JW Voncken; H van Schaick; Vesa Kaartinen; K Deemer; T Coates; B Landing; Paul K Pattengale; O Dorseuil; G M Bokoch; John Groffen
Increased neutrophil respiratory burst in bcr-null mutants.
Cell 1995;80(5):719-28.
1995: Christine Morris; Suzanne M Benjes; Leena Haataja; David Ledbetter; Nora Heisterkamp; John Groffen
Spatial organization of ABR and CRK genes on human chromosome band 17p13.3.
Oncogene 1995;10(5):1009-11.
1995: Ilkka Mononen; Nora Heisterkamp; U Dunder; EL Romppanen; Tiina Noronkoski; I Kuronen; John Groffen
Recombinant glycosylasparaginase and in vitro correction of aspartylglycosaminuria.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(5):428-33.
1995: T Fioretos; JW Voncken; T Z Baram; F Kamme; John Groffen; Nora Heisterkamp
Regional localization and developmental expression of the BCR gene in rodent brain.
Cellular & molecular biology research 1995;41(2):97-102.
1994: J ten Hoeve; R B Arlinghaus; J Q Guo; Nora Heisterkamp; John Groffen
Tyrosine phosphorylation of CRKL in Philadelphia+ leukemia.
Blood 1994;84(6):1731-6.
1994: T Fioretos; Nora Heisterkamp; John Groffen
No evidence for genomic imprinting of the human BCR gene.
Blood 1994;83(12):3441-4.
1994: J ten Hoeve; Vesa Kaartinen; T Fioretos; Leena Haataja; JW Voncken; Nora Heisterkamp; John Groffen
Cellular interactions of CRKL, and SH2-SH3 adaptor protein.
Cancer research 1994;54(10):2563-7.
1993: J ten Hoeve; Christine Morris; A Poustka; John Groffen; Nora Heisterkamp
Isolation of NotI sites from chromosome 22q11.
Genomics 1993;18(3):588-97.
1993: T Fioretos; Nora Heisterkamp; John Groffen; Suzanne M Benjes; Christine Morris
CRK proto-oncogene maps to human chromosome band 17p13.
Oncogene 1993;8(10):2853-5.
1993: J ten Hoeve; Christine Morris; Nora Heisterkamp; John Groffen
Isolation and chromosomal localization of CRKL, a human crk-like gene.
Oncogene 1993;8(9):2469-74.
1993: Nora Heisterkamp; Vesa Kaartinen; S van Soest; G M Bokoch; John Groffen
Human ABR encodes a protein with GAPrac activity and homology to the DBL nucleotide exchange factor domain.
The Journal of biological chemistry 1993;268(23):16903-6.
1993: Christine Morris; C Courtay; A Geurts van Kessel; J ten Hoeve; Nora Heisterkamp; John Groffen
Localization of a gamma-glutamyl-transferase-related gene family on chromosome 22.
Human genetics 1993;91(1):31-6.
1993: John Groffen; JW Voncken; Vesa Kaartinen; Christine Morris; Nora Heisterkamp
Ph-positive leukemia: a transgenic mouse model.
Leukemia & lymphoma 1993;11 Suppl 1():19-24.
1992: JW Voncken; S Griffiths; M F Greaves; Paul K Pattengale; Nora Heisterkamp; John Groffen
Restricted oncogenicity of BCR/ABL p190 in transgenic mice.
Cancer research 1992;52(16):4534-9.
1992: JW Voncken; Christine Morris; Paul K Pattengale; G Dennert; C Kikly; John Groffen; Nora Heisterkamp
Clonal development and karyotype evolution during leukemogenesis of BCR/ABL transgenic mice.
Blood 1992;79(4):1029-36.
1992: John Groffen; JW Voncken; H van Schaick; Nora Heisterkamp
Animal models for chronic myeloid leukemia and acute lymphoblastic leukemia.
Leukemia 1992;6 Suppl 1():44-6.
1991: Nora Heisterkamp; G Jenster; D Kioussis; Paul K Pattengale; John Groffen
Human bcr-abl gene has a lethal effect on embryogenesis.
Transgenic research 1991;1(1):45-53.
1991: Christine Morris; Nora Heisterkamp; John Groffen; P H Fitzgerald
Entire ABL gene is joined with 5'-BCR in some patients with Philadelphia-positive leukemia.
Blood 1991;78(4):1078-84.
1991: Nora Heisterkamp; E Rajpert-De Meyts; L Uribe; Henry Jay Forman; John Groffen
Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):6303-7.
1991: Christine Morris; M Kennedy; Nora Heisterkamp; L Columbano-Green; K Romeril; John Groffen; P Fitzgerald
A complex chromosome rearrangement forms the BCR-ABL fusion gene in leukemic cells with a normal karyotype.
Genes, chromosomes & cancer 1991;3(4):263-71.
1991: Christine Morris; Q L Hao; Nora Heisterkamp; P H Fitzgerald; John Groffen
Localization of the TRK proto-oncogene to human chromosome bands 1q23-1q24.
Oncogene 1991;6(6):1093-5.
1991: Q L Hao; D K Ferris; G White; Nora Heisterkamp; John Groffen
Nuclear and cytoplasmic location of the FER tyrosine kinase.
Molecular and cellular biology 1991;11(2):1180-3.
1991: Nora Heisterkamp; John Groffen
Molecular insights into the Philadelphia translocation.
Hematologic pathology 1991;5(1):1-10.
1990: Q S Zhu; Nora Heisterkamp; John Groffen
Unique organization of the human BCR gene promoter.
Nucleic acids research 1990;18(23):7119-25.
1990: Christine Morris; Nora Heisterkamp; M A Kennedy; P H Fitzgerald; John Groffen
Ph-negative chronic myeloid leukemia: molecular analysis of ABL insertion into M-BCR on chromosome 22.
Blood 1990;76(9):1812-8.
1990: D DiSilvestre; Christine Morris; Nora Heisterkamp; John Groffen
A second hypervariable RFLP within the ABR gene.
Nucleic acids research 1990;18(19):5925.
1990: D DiSilvestre; Christine Morris; Nora Heisterkamp; John Groffen
A hypervariable RFLP within the ABR gene.
Nucleic acids research 1990;18(19):5924.
1990: Q S Zhu; Nora Heisterkamp; John Groffen
Characterization of the human ABL promoter regions.
Oncogene 1990;5(6):885-91.
1990: Nora Heisterkamp; G Jenster; J ten Hoeve; D Zovich; Paul K Pattengale; John Groffen
Acute leukaemia in bcr/abl transgenic mice.
Nature 1990;344(6263):251-3.
1989: Nora Heisterkamp; Christine Morris; John Groffen
ABR, an active BCR-related gene.
Nucleic acids research 1989;17(21):8821-31.