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Marcela Gronda

Research Profile

Anatomy

Living Beings

Chemicals & Drugs

Procedures

Drug Screening Assays, Antitumor

Physiology

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Publications

TOP 3
Bozhena Jhas; Yulia Jitkova; Rob C Laister; Mark D Minden; Marko Skrtic; Shrivani Sriskanthadevan; Mahadeo A Sukhai; Veronique Voisin; Gary D Bader; Marcela Gronda; Rose Hurren; Aaron D Schimmer
Metabolic adaptation to chronic inhibition of mitochondrial protein synthesis in acute myeloid leukemia cells.
Aaron D Schimmer; Andre Schuh; Zezhou Wang; Karen Yee; Suzanne Ackloo; Tristan Booth; Joseph Brandwein; Christine Chen; Jian Chen; Marcela Gronda; Vikas Gupta; Yulia Jitkova; Sharon Keays; Mark D Minden
A phase I study of the metal ionophore clioquinol in patients with advanced hematologic malignancies.
Reza Beheshti Zavareh; Marcela Gronda; Rose Hurren; Troy Ketela; Neil Maclean; Jason Moffat; David R Rose; Harry Schachter; Aaron D Schimmer; Craig D Simpson; Mahadeo A Sukhai; Carol J Swallow; Xiaoming Wang; Francis Zih; James W Dennis
Suppression of cancer progression by MGAT1 shRNA knockdown.

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All Publications

2013: Bozhena Jhas; Yulia Jitkova; Rob C Laister; Mark D Minden; Marko Skrtic; Shrivani Sriskanthadevan; Mahadeo A Sukhai; Veronique Voisin; Gary D Bader; Marcela Gronda; Rose Hurren; Aaron D Schimmer
Metabolic adaptation to chronic inhibition of mitochondrial protein synthesis in acute myeloid leukemia cells.
PloS one 2013;8(3):e58367.
2012: Aaron D Schimmer; Andre Schuh; Zezhou Wang; Karen Yee; Suzanne Ackloo; Tristan Booth; Joseph Brandwein; Christine Chen; Jian Chen; Marcela Gronda; Vikas Gupta; Yulia Jitkova; Sharon Keays; Mark D Minden
A phase I study of the metal ionophore clioquinol in patients with advanced hematologic malignancies.
Clinical lymphoma, myeloma & leukemia 2012;12(5):330-6.
2012: Reza Beheshti Zavareh; Marcela Gronda; Rose Hurren; Troy Ketela; Neil Maclean; Jason Moffat; David R Rose; Harry Schachter; Aaron D Schimmer; Craig D Simpson; Mahadeo A Sukhai; Carol J Swallow; Xiaoming Wang; Francis Zih; James W Dennis
Suppression of cancer progression by MGAT1 shRNA knockdown.
PloS one 2012;7(9):e43721.
2011: Siyuan Song; Ratheesh Subramaniam; Scott J Weir; Jeffrey L Wrana; Rima Al-awar; Solmaz Alizadeh; Ahmed Aman; Ren-Yue Bao; Anh Chau; Tania Christova; Marcela Gronda; Donna E Hogge; Rose Hurren; Methvin Isaac; Yulia Jitkova; Babu Joseph; James Kasper; Bryan W Miller; Stephen Perusini; Aaron D Schimmer; Liliana Attisano
Wnt inhibitor screen reveals iron dependence of β-catenin signaling in cancers.
Cancer research 2011;71(24):7628-39.
2011: Marko Skrtić; Paul Spagnuolo; Shrivani Sriskanthadevan; Jean C Y Wang; Xiaoming Wang; Zezhou Wang; Jeffery Wrana; Justyna Bartoszko; Jessie H Cameron; Alessandro Datti; John E Dick; Connie J Eaves; Yanina Eberhard; Marinella Gebbia; Guri Giaever; Marcela Gronda; Keith Humphries; Rose Hurren; Bozhena Jhas; Yulia Jitkova; Troy Ketela; Courteney K Lai; Neil Maclean; Mark D Minden; Jason Moffat; Corey Nislow; Brian H Robinson; Angela C Rutledge; Aaron D Schimmer
Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia.
Cancer cell 2011;20(5):674-88.
2011: Sonali B Fonseca; Mark P Pereira; Rida Mourtada; Marcela Gronda; Kristin L Horton; Rose Hurren; Mark D Minden; Aaron D Schimmer; Shana O Kelley
Rerouting chlorambucil to mitochondria combats drug deactivation and resistance in cancer cells.
Chemistry & biology 2011;18(4):445-53.
2011: Yanina Eberhard; Marcela Gronda; Rose Hurren; Alessandro Datti; Neil MacLean; Troy Ketela; Jason Moffat; Jeffrey L Wrana; Aaron D Schimmer
Inhibition of SREBP1 sensitizes cells to death ligands.
Oncotarget 2011;2(3):186-96.
2010: Sumaiya Sharmeen; Marko Skrtic; Mahadeo A Sukhai; Rose Hurren; Marcela Gronda; Xiaoming Wang; Sonali B Fonseca; Hong Sun; Tabitha E Wood; Richard Ward; Mark D Minden; Robert A Batey; Alessandro Datti; Jeffrey L Wrana; Shana O Kelley; Aaron D Schimmer
The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells.
Blood 2010;116(18):3593-603.
2010: Paul A Spagnuolo; Jiayi Hu; Rose Hurren; Xiaoming Wang; Marcela Gronda; Mahadeo A Sukhai; Ashley Di Meo; Jonathan Boss; Iman Ashali; Reza Beheshti Zavareh; Noah Fine; Craig D Simpson; Sumaiya Sharmeen; Robert Rottapel; Aaron D Schimmer
The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma.
Blood 2010;115(23):4824-33.
2010: G Wei Xu; Mohsin Ali; Tabitha E Wood; Derek Wong; Neil Maclean; Xiaoming Wang; Marcela Gronda; Marko Skrtic; Xiaoming Li; Rose Hurren; Xinliang Mao; Meenakshi Venkatesan; Reza Beheshti Zavareh; Troy Ketela; John C Reed; David Rose; Jason Moffat; Robert A Batey; Sirano Dhe-Paganon; Aaron D Schimmer
The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma.
Blood 2010;115(11):2251-9.
2010: Tabitha E Wood; Shadi Dalili; Craig D Simpson; Mahadeo A Sukhai; Rose Hurren; Kika Anyiwe; Xinliang Mao; Fernando Suarez Saiz; Marcela Gronda; Yanina Eberhard; Neil MacLean; Troy Ketela; John C Reed; Jason Moffat; Mark D Minden; Robert A Batey; Aaron D Schimmer
Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands.
Molecular cancer therapeutics 2010;9(1):246-56.
2009: Yanina Eberhard; Sean McDermott; Xiaoming Wang; Marcela Gronda; Amudha Venugopal; Tabitha E Wood; Rose Hurren; Alessandro Datti; Robert A Batey; Jeffrey L Wrana; William E Antholine; John E Dick; John Dick; Aaron D Schimmer
Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.
Blood 2009;114(14):3064-73.
2009: Craig D Simpson; Imtiaz A Mawji; Kika Anyiwe; Moyo A Williams; Xiaoming Wang; Amudha L Venugopal; Marcela Gronda; Rose Hurren; Sonia Cheng; Stefano Serra; Reza Beheshti Zavareh; Alessandro Datti; Jeffrey L Wrana; Shereen Ezzat; Aaron D Schimmer
Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation.
Cancer research 2009;69(7):2739-47.
2008: Reza Beheshti Zavareh; Ken S Lau; Rose Hurren; Alessandro Datti; David J Ashline; Marcela Gronda; Pam Cheung; Craig D Simpson; Wei Liu; Amanda R Wasylishen; Paul C Boutros; Hui Shi; Amudha Vengopal; Igor Jurisica; Linda Z Penn; Vern N Reinhold; Shereen Ezzat; Jeffrey L Wrana; David R Rose; Harry Schachter; James W Dennis; Aaron D Schimmer
Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function.
Cancer research 2008;68(16):6688-97.
2007: Imtiaz A Mawji; Craig D Simpson; Marcela Gronda; Moyo A Williams; Rose Hurren; Clare J Henderson; Alessandro Datti; Jeffrey L Wrana; Aaron D Schimmer
A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis.
Cancer research 2007;67(17):8307-15.
2007: Imtiaz A Mawji; Craig D Simpson; Rose Hurren; Marcela Gronda; Moyo A Williams; Jorge Filmus; James Jonkman; Ralph S Da Costa; Brian C Wilson; Michael P Thomas; John C Reed; Gennadi V Glinsky; Aaron D Schimmer
Critical role for Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein in anoikis resistance and distant tumor formation.
Journal of the National Cancer Institute 2007;99(10):811-22.
2006: Debbie M Gurfinkel; Sue Chow; Rose Hurren; Marcela Gronda; Clare Henderson; Christina Berube; David W Hedley; Aaron D Schimmer
Disruption of the endoplasmic reticulum and increases in cytoplasmic calcium are early events in cell death induced by the natural triterpenoid Asiatic acid.
Apoptosis : an international journal on programmed cell death 2006;11(9):1463-71.
2006: Aaron D Schimmer; Michael P Thomas; Rose Hurren; Marcela Gronda; Maurizio Pellecchia; Gregory R Pond; Marina Konopleva; Debbie Gurfinkel; Imtiaz A Mawji; Ewan Brown; John C Reed
Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors.
Cancer research 2006;66(4):2367-75.
2005: Marcela Gronda; Joseph Brandwein; Mark D Minden; G R Pond; Andre C Schuh; Richard A Wells; Hans A Messner; Kathy Chun; Aaron D Schimmer
Assessment of the downstream portion of the mitochondrial pathway of caspase activation in patients with acute myeloid leukemia.
Apoptosis : an international journal on programmed cell death 2005;10(6):1285-94.
2005: Bing Z Carter; Marcela Gronda; Zhiliang Wang; Kate Welsh; Clemencia Pinilla; Michael Andreeff; Wendy D Schober; Adel Nefzi; Gregory R Pond; Imtiaz A Mawji; Richard A Houghten; John M Ostresh; Joseph Brandwein; Mark D Minden; Andre C Schuh; Richard A Wells; Hans A Messner; Kathy Chun; John C Reed; Aaron D Schimmer
Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells.
Blood 2005;105(10):4043-50.
2004: Nhu-An Pham; James Jacobberger; Aaron D Schimmer; Pinjiang Cao; Marcela Gronda; David W Hedley
The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice.
Molecular cancer therapeutics 2004;3(10):1239-48.
2001: Marcela Gronda; Sara Arab; B Iafrate; H Suzuki; Brent Zanke
Hematopoietic protein tyrosine phosphatase suppresses extracellular stimulus-regulated kinase activation.
Molecular and cellular biology 2001;21(20):6851-8.
2000: M Kim; Marcela Gronda; Hans A Messner; James R Ballinger
Accumulation of sestamibi in lymphoma cell lines in vitro.
Leukemia & lymphoma 2000;38(5-6):599-603.
1999: F Omori; Hans A Messner; C Ye; Marcela Gronda; J P O'Neill; H Atkins; Hong-Qiang Heng
Nontargeted stable integration of recombinant adeno-associated virus into human leukemia and lymphoma cell lines as evaluated by fluorescence in situ hybridization.
Human gene therapy 1999;10(4):537-43.